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Overview

ID MAG00408
Name CMS2_bin.103
Sample SMP0011
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus Methanothrix
Species
Assembly information
Completeness (%) 53.16
Contamination (%) 0.37
GC content (%) 52.0
N50 (bp) 2,224
Genome size (bp) 1,101,499

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1172

Gene name Description KEGG GOs EC E-value Score Sequence
CMS2_k127_1002106_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 292.0
CMS2_k127_1002106_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001596 273.0
CMS2_k127_1002106_2 Belongs to the HesB IscA family K13628 - - 0.000001079 55.0
CMS2_k127_1021286_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 556.0
CMS2_k127_1021286_1 GvpD gas vesicle protein - - - 0.00000000000000004241 83.0
CMS2_k127_1031121_0 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 458.0
CMS2_k127_1031121_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000002438 186.0
CMS2_k127_1036719_0 oligoendopeptidase F K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006859 419.0
CMS2_k127_1036719_1 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000005572 109.0
CMS2_k127_1039359_0 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000000008775 196.0
CMS2_k127_1039359_1 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000845 161.0
CMS2_k127_1039359_2 to PID 1652090 percent identity - - - 0.000000000000000000000000000000001024 134.0
CMS2_k127_1039359_3 nucleotidyltransferase activity K07075 - - 0.0000000000000009667 78.0
CMS2_k127_1039359_4 - - - - 0.000000000000009597 78.0
CMS2_k127_1041198_0 Formate dehydrogenase alpha subunit K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 614.0
CMS2_k127_1041198_1 Terminase RNaseH-like domain - - - 0.00000113 52.0
CMS2_k127_1067869_0 Pfam:UPF0118 - - - 0.0000000000000000000000001275 113.0
CMS2_k127_1119217_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 514.0
CMS2_k127_1125136_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 581.0
CMS2_k127_112925_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 293.0
CMS2_k127_112925_1 Flavoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002837 240.0
CMS2_k127_112925_2 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.0000000000000000000000003558 108.0
CMS2_k127_1143307_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 296.0
CMS2_k127_1143307_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000152 277.0
CMS2_k127_1143307_2 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000001797 238.0
CMS2_k127_1159199_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 4.522e-210 662.0
CMS2_k127_1159199_1 NADP oxidoreductase, coenzyme F420-dependent K00286 - 1.5.1.2 0.0000000000009076 70.0
CMS2_k127_1160449_0 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000004644 203.0
CMS2_k127_1160449_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000004447 82.0
CMS2_k127_1160449_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000003316 75.0
CMS2_k127_1167226_0 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000005997 237.0
CMS2_k127_1167549_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 400.0
CMS2_k127_1183503_0 TrkA-C domain - - - 0.000000000000000000007215 96.0
CMS2_k127_1183503_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000007726 85.0
CMS2_k127_1188334_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 389.0
CMS2_k127_1199416_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 380.0
CMS2_k127_1199416_1 COG0224 F0F1-type ATP synthase gamma subunit K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009387 263.0
CMS2_k127_1199416_2 PFAM Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000004429 223.0
CMS2_k127_1199416_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000005951 72.0
CMS2_k127_1202892_0 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000001746 162.0
CMS2_k127_1202892_1 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000002379 130.0
CMS2_k127_1202892_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000005651 87.0
CMS2_k127_1211322_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 400.0
CMS2_k127_1211322_1 Protein of unknown function (DUF1624) - - - 0.000000000006586 66.0
CMS2_k127_1212534_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 288.0
CMS2_k127_1212534_1 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000859 197.0
CMS2_k127_1217454_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 380.0
CMS2_k127_1217454_1 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000000000000000000000000000008324 241.0
CMS2_k127_1228066_0 Required for chromosome condensation and partitioning K03529 - - 3.721e-288 923.0
CMS2_k127_1228066_1 Segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000987 144.0
CMS2_k127_1230083_0 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 499.0
CMS2_k127_1230083_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000003099 237.0
CMS2_k127_1252659_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 426.0
CMS2_k127_1252659_1 helicase superfamily c-terminal domain K03725 - - 0.0000000005405 62.0
CMS2_k127_1252659_2 domain, Protein - - - 0.000008741 49.0
CMS2_k127_1252659_3 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00002382 51.0
CMS2_k127_1252659_4 domain, Protein K01179,K15125 - 3.2.1.4 0.00006845 52.0
CMS2_k127_1252911_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 517.0
CMS2_k127_1252911_1 PFAM Thiolase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 400.0
CMS2_k127_1252911_2 Helix-turn-helix domain protein K07731 - - 0.00000000000000000000000000000000000000000000000000000000002888 211.0
CMS2_k127_1255872_0 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 368.0
CMS2_k127_1256227_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000002549 83.0
CMS2_k127_1256227_1 PFAM Uncharacterised conserved protein UCP019262 - - - 0.0000000000002053 79.0
CMS2_k127_1266781_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 3.016e-275 861.0
CMS2_k127_1266781_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0002068 51.0
CMS2_k127_1282150_0 Segregation and condensation complex subunit ScpB K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000005657 246.0
CMS2_k127_1282150_1 Mediates influx of magnesium ions K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.0000000000000000000000001622 106.0
CMS2_k127_1282150_2 COG3547 Transposase and inactivated derivatives - - - 0.0000000004574 61.0
CMS2_k127_1291826_0 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007031 235.0
CMS2_k127_1291826_1 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000000000000000009032 153.0
CMS2_k127_1291826_2 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000799 127.0
CMS2_k127_1291826_3 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000000000000000566 114.0
CMS2_k127_1291960_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 333.0
CMS2_k127_1291960_1 NADH ubiquinone oxidoreductase, 20 Kd subunit K22159 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
CMS2_k127_1291960_2 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.0000000000000000000000000000000000000000006926 166.0
CMS2_k127_1291960_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000008178 119.0
CMS2_k127_1291960_4 Predicted nucleotidyltransferase K07074 - - 0.000005896 56.0
CMS2_k127_1320879_0 Protein of unknown function, DUF255 K06888 - - 1.543e-197 632.0
CMS2_k127_1344832_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.406e-202 640.0
CMS2_k127_1344832_1 Tetratricopeptide repeat - - - 0.00000000000000003356 92.0
CMS2_k127_1361552_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 294.0
CMS2_k127_1361552_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000004612 124.0
CMS2_k127_1361552_2 - - - - 0.0000000000000006785 83.0
CMS2_k127_1367198_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000001297 246.0
CMS2_k127_1367198_1 - - - - 0.000000000002571 73.0
CMS2_k127_1377300_0 in RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 427.0
CMS2_k127_1377300_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000005207 261.0
CMS2_k127_1377300_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.00000000001505 67.0
CMS2_k127_1456265_0 Putative small multi-drug export protein - - - 0.00000000000000000000000000000000000000000000001165 175.0
CMS2_k127_1456265_1 Dihydrouridine synthase (Dus) - - - 0.0000000000002581 77.0
CMS2_k127_1484282_0 sugar phosphatases of the HAD superfamily K02566 - - 0.000000000000000000000000000000000000000000000001552 180.0
CMS2_k127_1484282_1 - - - - 0.000000008847 63.0
CMS2_k127_1497988_0 sugar phosphatases of the HAD superfamily K01101,K02566 - 3.1.3.41 0.00000000000000000000000000005979 117.0
CMS2_k127_1497988_1 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000008397 112.0
CMS2_k127_1497988_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.00000000000000000001428 95.0
CMS2_k127_1505327_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.969e-227 725.0
CMS2_k127_1505327_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000005911 105.0
CMS2_k127_1539723_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 305.0
CMS2_k127_1575436_0 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 404.0
CMS2_k127_1575436_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000164 156.0
CMS2_k127_1598082_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.739e-280 874.0
CMS2_k127_1604646_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000009084 235.0
CMS2_k127_1604646_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000004952 208.0
CMS2_k127_1604646_2 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000148 183.0
CMS2_k127_1617330_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 401.0
CMS2_k127_1632270_0 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000001619 88.0
CMS2_k127_1648056_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 554.0
CMS2_k127_1648056_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 487.0
CMS2_k127_1650573_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 538.0
CMS2_k127_1650573_1 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000005794 156.0
CMS2_k127_1664895_0 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 312.0
CMS2_k127_1664895_1 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000003283 263.0
CMS2_k127_1674277_0 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001104 254.0
CMS2_k127_1674277_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000007659 236.0
CMS2_k127_1688677_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000001687 177.0
CMS2_k127_1704051_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000005146 262.0
CMS2_k127_1730113_0 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009024 450.0
CMS2_k127_1730113_1 Protein of unknown function (DUF1614) - - - 0.000000000000000000000001221 111.0
CMS2_k127_1735109_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 318.0
CMS2_k127_1738894_0 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 461.0
CMS2_k127_176063_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 5.779e-206 663.0
CMS2_k127_176063_1 adenyl ribonucleotide binding - - - 0.00000000000000000000000000000000006823 141.0
CMS2_k127_176063_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000006582 131.0
CMS2_k127_1768169_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 400.0
CMS2_k127_1768169_1 phosphoribosyltransferase K07101 - - 0.000000000000000000000000000000386 126.0
CMS2_k127_1771284_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 5.609e-240 752.0
CMS2_k127_1800745_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 473.0
CMS2_k127_1811858_0 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 303.0
CMS2_k127_1811858_1 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000001469 96.0
CMS2_k127_1828217_0 Cation transport ATPase K01535,K01537 - 3.6.3.6,3.6.3.8 0.000000000000000000000000000000000000000000000000004759 185.0
CMS2_k127_1828217_1 COG0589 Universal stress protein UspA and related nucleotide-binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000009547 120.0
CMS2_k127_182846_0 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 301.0
CMS2_k127_182846_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000000000000006727 207.0
CMS2_k127_1828715_0 Histidine kinase - - - 0.00000000000000000009354 94.0
CMS2_k127_1828715_1 Thiamine-binding protein - - - 0.0000000000000003083 81.0
CMS2_k127_1831899_0 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 359.0
CMS2_k127_1840165_0 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 295.0
CMS2_k127_1906543_0 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000867 432.0
CMS2_k127_1906543_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 311.0
CMS2_k127_1906543_2 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0003641 43.0
CMS2_k127_1914915_0 eRF1 domain 2 - - - 0.00000000000000000000009547 109.0
CMS2_k127_1919967_0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 363.0
CMS2_k127_1919967_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001039 278.0
CMS2_k127_1919967_2 S-layer protein - - - 0.000009003 53.0
CMS2_k127_1922086_0 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 349.0
CMS2_k127_1922086_1 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000005179 177.0
CMS2_k127_1922086_2 Secreted repeat of unknown function - - - 0.00000000000000000000000009426 112.0
CMS2_k127_1922086_3 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000000000000000005122 98.0
CMS2_k127_1929574_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 394.0
CMS2_k127_1929574_1 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000001003 273.0
CMS2_k127_1929905_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000836 425.0
CMS2_k127_1929905_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007895 274.0
CMS2_k127_1946192_0 NurA - - - 0.0000000924 61.0
CMS2_k127_1947720_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 328.0
CMS2_k127_1947720_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000001094 168.0
CMS2_k127_1947759_0 GXGXG motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 314.0
CMS2_k127_1947759_1 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000008221 127.0
CMS2_k127_1951891_0 Has ATPase and non-specific DNA-binding activities K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 383.0
CMS2_k127_1953626_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1302.0
CMS2_k127_1953626_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 485.0
CMS2_k127_1953626_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 392.0
CMS2_k127_1953626_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000001752 237.0
CMS2_k127_1953626_4 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000005891 218.0
CMS2_k127_1953626_5 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000005289 192.0
CMS2_k127_1953626_6 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000000000000000000000004205 111.0
CMS2_k127_197675_0 COG0457 FOG TPR repeat - - - 1.697e-231 729.0
CMS2_k127_197675_1 Cytochrome b/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000001083 205.0
CMS2_k127_2009729_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 545.0
CMS2_k127_2009729_1 aconitate hydratase K01681 - 4.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001898 263.0
CMS2_k127_2020213_0 PFAM Appr-1-p processing - - - 0.0000000000000000000000000000000000000000000000000000000000000003832 224.0
CMS2_k127_2053788_0 COG1960 Acyl-CoA dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000002063 198.0
CMS2_k127_2053788_1 COG1960 Acyl-CoA dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000009552 196.0
CMS2_k127_2084613_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000105 256.0
CMS2_k127_2084613_1 KH, type 1, domain K07041 - - 0.0000000000000000000000000000001096 127.0
CMS2_k127_2084613_2 Membrane protein of unknown function DUF63 - - - 0.0000000000000000000000002797 109.0
CMS2_k127_2090705_0 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 307.0
CMS2_k127_2090705_1 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000006655 76.0
CMS2_k127_2116154_0 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 418.0
CMS2_k127_2149741_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 382.0
CMS2_k127_2149741_1 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000003327 142.0
CMS2_k127_2163682_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 343.0
CMS2_k127_2163682_1 S-layer protein - - - 0.000000005786 59.0
CMS2_k127_2175729_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 441.0
CMS2_k127_2175729_1 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000003324 127.0
CMS2_k127_220074_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000002822 243.0
CMS2_k127_220074_1 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000001088 108.0
CMS2_k127_2206096_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000004644 212.0
CMS2_k127_222146_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 325.0
CMS2_k127_2224603_0 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001791 252.0
CMS2_k127_2224603_1 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000001542 177.0
CMS2_k127_2224603_2 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000006669 175.0
CMS2_k127_2226677_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 403.0
CMS2_k127_2226677_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 371.0
CMS2_k127_2226677_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000005878 83.0
CMS2_k127_2263726_0 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000004422 194.0
CMS2_k127_2263726_1 Right handed beta helix region - - - 0.000000000000001665 86.0
CMS2_k127_2272221_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000017 202.0
CMS2_k127_2272221_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000006278 187.0
CMS2_k127_2281897_0 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000003014 211.0
CMS2_k127_2281897_1 Protein of unknown function (DUF3467) - - - 0.000000000000000000000000000001094 128.0
CMS2_k127_2281897_2 Permeases of the major facilitator superfamily K08153 - - 0.0000000000000000000002934 107.0
CMS2_k127_2281897_3 Lrp/AsnC ligand binding domain - - - 0.00000000000000005834 83.0
CMS2_k127_2281897_4 Tetratricopeptide repeat - - - 0.000000000000005452 82.0
CMS2_k127_2281897_5 Major Facilitator Superfamily - - - 0.0002801 46.0
CMS2_k127_229206_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 316.0
CMS2_k127_229206_1 Sodium:solute symporter family K03307 - - 0.0000000000000000000000000004516 119.0
CMS2_k127_2295912_0 Cys/Met metabolism PLP-dependent enzyme K01758,K01761 - 4.4.1.1,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 469.0
CMS2_k127_230106_0 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000007051 158.0
CMS2_k127_230106_1 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000001253 123.0
CMS2_k127_230106_2 DNA-binding transcription factor activity - - - 0.00000002456 59.0
CMS2_k127_2304063_0 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 351.0
CMS2_k127_2304063_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000004392 191.0
CMS2_k127_2304063_2 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.0000000000000000000001426 98.0
CMS2_k127_2308261_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 517.0
CMS2_k127_2308261_1 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000006533 176.0
CMS2_k127_2310490_0 - - - - 0.000000000009457 70.0
CMS2_k127_2325162_0 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000002417 193.0
CMS2_k127_2325162_1 nucleic acid phosphodiester bond hydrolysis K07576 - - 0.000000000000000000000006447 105.0
CMS2_k127_2351450_0 periplasmic K07218 - - 0.000000000008344 78.0
CMS2_k127_235997_0 DEAD DEAH box helicase domain protein K10896 - - 0.00000000000000000000000000000000000000000000000000000000000001469 224.0
CMS2_k127_235997_1 Thioredoxin K03671 - - 0.0000000000000001856 87.0
CMS2_k127_2372594_0 NnrU protein K21310 - 2.1.1.334 0.00000000000000000000000000000000000000000000000000000000002162 212.0
CMS2_k127_2372594_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000005133 116.0
CMS2_k127_2372594_2 - - - - 0.0000000000001514 75.0
CMS2_k127_2372594_3 2TM domain - - - 0.0000007376 54.0
CMS2_k127_2374484_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 9.007e-212 670.0
CMS2_k127_2376299_0 HI0933 family K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 351.0
CMS2_k127_2377417_0 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001289 269.0
CMS2_k127_2377417_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000004536 251.0
CMS2_k127_2398105_0 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002853 258.0
CMS2_k127_2398105_1 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000002162 112.0
CMS2_k127_2402612_0 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 355.0
CMS2_k127_2424194_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 350.0
CMS2_k127_2424194_1 coenzyme F420 binding K00275 - 1.4.3.5 0.000000000000000000000000000000005929 133.0
CMS2_k127_2445938_0 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 403.0
CMS2_k127_2445938_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.00000000000000000000000000000000000009268 148.0
CMS2_k127_2445938_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000005398 60.0
CMS2_k127_2447695_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.000000000000000000000000000000000002466 143.0
CMS2_k127_2447695_1 pfam nmd3 K07562 - - 0.000000000000001606 83.0
CMS2_k127_2461421_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009534 282.0
CMS2_k127_2461421_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000005121 173.0
CMS2_k127_2461421_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000001645 111.0
CMS2_k127_2463666_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 369.0
CMS2_k127_2473178_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.577e-232 729.0
CMS2_k127_2473178_1 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 362.0
CMS2_k127_2477303_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 499.0
CMS2_k127_2477303_1 CHAT domain - - - 0.00000000000000000000000000000000007841 152.0
CMS2_k127_2477303_2 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000009083 101.0
CMS2_k127_2477303_3 - - - - 0.0004289 50.0
CMS2_k127_2507765_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000942 136.0
CMS2_k127_2507765_1 PFAM Fe-S cluster domain protein K06939 - - 0.000000000000000000000000000009659 125.0
CMS2_k127_2507765_2 PFAM cobalamin synthesis protein P47K - - - 0.00000000000000000000000002592 108.0
CMS2_k127_2513764_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 307.0
CMS2_k127_2513764_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000004768 210.0
CMS2_k127_2513764_2 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000772 196.0
CMS2_k127_2513764_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000005947 109.0
CMS2_k127_2513764_4 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000001 63.0
CMS2_k127_2519743_0 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000004257 219.0
CMS2_k127_2519743_1 Reverse transcriptase-like K03469 - 3.1.26.4 0.00000000000000000000000000008332 123.0
CMS2_k127_2519743_2 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000002043 58.0
CMS2_k127_2527655_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000012 291.0
CMS2_k127_2527655_1 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003948 287.0
CMS2_k127_2527655_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000001488 186.0
CMS2_k127_2535445_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009154 265.0
CMS2_k127_2558970_0 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 317.0
CMS2_k127_2558970_1 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 301.0
CMS2_k127_2558970_2 Universal stress protein family - - - 0.000000000000000000000000000000005882 132.0
CMS2_k127_2566161_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 311.0
CMS2_k127_2566161_1 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.00000000000000000000000000000000006092 142.0
CMS2_k127_2566161_2 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000005719 114.0
CMS2_k127_258033_0 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000002699 192.0
CMS2_k127_258033_1 Putative zinc- or iron-chelating domain K06940 - - 0.00000009269 62.0
CMS2_k127_2586917_0 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 288.0
CMS2_k127_2592479_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 533.0
CMS2_k127_2592479_1 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000002629 181.0
CMS2_k127_2593650_0 Archaeal Nre, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 388.0
CMS2_k127_2593650_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 307.0
CMS2_k127_2593650_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000008354 170.0
CMS2_k127_2594239_0 Dna alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007486 310.0
CMS2_k127_2594239_1 metal-dependent membrane protease - - - 0.000000000000000000000000000002069 134.0
CMS2_k127_2600685_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000007768 263.0
CMS2_k127_2600685_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000006208 201.0
CMS2_k127_2602792_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 582.0
CMS2_k127_2602792_1 4Fe-4S dicluster domain K00196 - - 0.0000000000000000000000000000000000000000000000001584 183.0
CMS2_k127_2602792_2 PFAM GvpD gas vesicle - - - 0.000000000000005689 82.0
CMS2_k127_2608864_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 2.247e-228 727.0
CMS2_k127_2615679_0 ATPases associated with a variety of cellular activities K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001658 278.0
CMS2_k127_2615679_1 ABC-3 protein K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
CMS2_k127_2615679_2 Zinc-uptake complex component A periplasmic K02077,K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001851 252.0
CMS2_k127_2615679_3 - - - - 0.000000000001086 70.0
CMS2_k127_2616052_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 522.0
CMS2_k127_2616052_1 PFAM peptidase M42 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 453.0
CMS2_k127_2616052_2 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000003385 194.0
CMS2_k127_2623185_0 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 402.0
CMS2_k127_2623185_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000002857 192.0
CMS2_k127_2637050_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 607.0
CMS2_k127_2637050_1 RNA-binding protein of the translin family K07477 - - 0.0000000000000000000000000000000000000000000005216 174.0
CMS2_k127_2637050_2 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000005323 128.0
CMS2_k127_2647418_0 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 312.0
CMS2_k127_2647418_1 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002867 280.0
CMS2_k127_2647418_2 PFAM 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000001385 109.0
CMS2_k127_2647418_3 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000000000000000005795 84.0
CMS2_k127_2653378_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 353.0
CMS2_k127_2653378_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003702 250.0
CMS2_k127_2656872_0 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000001616 197.0
CMS2_k127_2656872_1 phosphonoacetaldehyde hydrolase activity K01560,K07025 - 3.8.1.2 0.0000000000000000000000000000000000000000000000001344 182.0
CMS2_k127_2658737_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 619.0
CMS2_k127_2658737_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 355.0
CMS2_k127_2658737_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002059 251.0
CMS2_k127_2658737_3 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000009185 148.0
CMS2_k127_2658737_4 ATP synthase F(0) sector subunit b' K02109 - - 0.00000000000000000000000000000000000004365 152.0
CMS2_k127_2658737_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000858 129.0
CMS2_k127_2658737_6 TIGRFAM F0F1-ATPase subunit K02116 - - 0.00000000000000000000000000000006293 126.0
CMS2_k127_2658737_7 N-ATPase, AtpR subunit - - - 0.00000000000002278 76.0
CMS2_k127_2679851_0 DEAD DEAH box helicase domain protein K03724 - - 6.271e-256 809.0
CMS2_k127_268492_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.444e-272 852.0
CMS2_k127_268492_1 AAA family ATPase, CDC48 subfamily K13525 - - 4.064e-203 641.0
CMS2_k127_268492_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000004699 143.0
CMS2_k127_2695849_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 505.0
CMS2_k127_2695849_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000002952 156.0
CMS2_k127_2695849_2 Helix-turn-helix XRE-family like proteins K03627 - - 0.0000000000000000000000000000000000001104 147.0
CMS2_k127_2713816_0 - - - - 0.0002199 50.0
CMS2_k127_2713816_1 PFAM TM2 domain containing protein K03686 - - 0.0002445 46.0
CMS2_k127_271530_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 314.0
CMS2_k127_271530_1 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000006215 63.0
CMS2_k127_2728031_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000002592 110.0
CMS2_k127_2729532_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 321.0
CMS2_k127_2729532_1 RNA-binding PUA-like domain of methyltransferase RsmF - - - 0.0000000000000000001671 92.0
CMS2_k127_2732417_0 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000003099 237.0
CMS2_k127_2732417_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000003644 182.0
CMS2_k127_2732417_2 PFAM Nucleoside 2-deoxyribosyltransferase - - - 0.000000000000000000000000000009917 123.0
CMS2_k127_2732417_3 tRNA binding K04566 - 6.1.1.6 0.00000000000000000000000001508 112.0
CMS2_k127_274795_0 cytochrome c biogenesis protein K06196 - - 0.00000000000693 78.0
CMS2_k127_2775636_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000003143 197.0
CMS2_k127_2775636_1 Diguanylate cyclase - - - 0.0000000000000001739 89.0
CMS2_k127_2789488_0 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 296.0
CMS2_k127_2789488_1 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000001231 100.0
CMS2_k127_2791476_0 - - - - 0.0000000000000000000000000000000000000007964 153.0
CMS2_k127_2791476_1 - - - - 0.000000000317 64.0
CMS2_k127_2791476_2 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000007034 51.0
CMS2_k127_2809206_0 CoA binding domain - - - 1.34e-268 842.0
CMS2_k127_282100_0 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469,K01473 - 3.5.2.14,3.5.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 557.0
CMS2_k127_2825037_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000005169 257.0
CMS2_k127_2825037_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000008666 116.0
CMS2_k127_2825037_2 Protein of unknown function (DUF1699) - - - 0.000000000000000000000005348 103.0
CMS2_k127_2825131_0 domain, Protein - - - 0.00005475 54.0
CMS2_k127_2835047_0 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002465 281.0
CMS2_k127_2835047_1 Major Facilitator Superfamily - - - 0.000000000000000000000000001338 117.0
CMS2_k127_2839844_0 Aminotransferase K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000002192 235.0
CMS2_k127_2839844_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.0000000000000003446 85.0
CMS2_k127_2846464_0 EamA-like transporter family - - - 0.00001606 56.0
CMS2_k127_2866463_0 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003374 275.0
CMS2_k127_2866463_1 PhoQ Sensor K07678,K11527,K20974 - 2.7.13.3 0.0000000000000000004235 93.0
CMS2_k127_2866463_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.000000001039 59.0
CMS2_k127_2883181_0 DEAD DEAH box helicase domain protein K03725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 501.0
CMS2_k127_2915539_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 500.0
CMS2_k127_29223_0 permease K03299 - - 0.0000000000000000000000000000000000000000000000000000000000000006877 234.0
CMS2_k127_2932395_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 415.0
CMS2_k127_2932395_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000004082 104.0
CMS2_k127_2934304_0 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000112 268.0
CMS2_k127_2938179_0 - - - - 0.00000000000000000000000000000000000001069 151.0
CMS2_k127_2938179_1 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0004585 44.0
CMS2_k127_2945963_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000006812 211.0
CMS2_k127_2945963_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000006207 126.0
CMS2_k127_2945963_2 extracellular matrix structural constituent - - - 0.0000000002604 71.0
CMS2_k127_2982707_0 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000005275 220.0
CMS2_k127_2982707_1 - - - - 0.0000000000000000000000196 104.0
CMS2_k127_3040500_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 1.501e-210 662.0
CMS2_k127_3040500_1 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000002919 84.0
CMS2_k127_3045291_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 367.0
CMS2_k127_3045291_1 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 327.0
CMS2_k127_3045291_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000009661 208.0
CMS2_k127_3047144_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 378.0
CMS2_k127_3047144_1 histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 312.0
CMS2_k127_3047144_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000001822 91.0
CMS2_k127_3088666_0 Zn-dependent hydrolases of the - - - 0.000000000000000000000000000000000000000000000000000000000000311 219.0
CMS2_k127_3113526_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 324.0
CMS2_k127_3115836_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 565.0
CMS2_k127_3129817_0 Lycopene cyclase protein - - - 0.000000000000000000000000000000000000000000000000000000000000000004684 236.0
CMS2_k127_3170264_0 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 358.0
CMS2_k127_3170264_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088,K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000007124 179.0
CMS2_k127_3170264_2 - - - - 0.0000000001439 63.0
CMS2_k127_319538_0 Involved in cell shape control K22222 - - 0.0000000000000000000000000000000000000000000000000000000000003614 217.0
CMS2_k127_319538_1 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000004214 165.0
CMS2_k127_319538_2 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000158 141.0
CMS2_k127_3203030_0 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 466.0
CMS2_k127_3203030_1 - - - - 0.0000000000000000000000000000000000000000000000000000000003988 213.0
CMS2_k127_3203030_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000001053 166.0
CMS2_k127_3216142_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000002661 215.0
CMS2_k127_3216142_1 SMART regulatory protein AsnC Lrp family K22225 - - 0.000000000000000000000000000000000000000000003023 170.0
CMS2_k127_3216142_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000001962 155.0
CMS2_k127_3216142_3 Right handed beta helix region - - - 0.0000000000000000000000000000000000003014 159.0
CMS2_k127_3224807_0 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007936 343.0
CMS2_k127_3224807_1 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000000000000007798 195.0
CMS2_k127_3241583_0 membrane protein domain - - - 0.0000000003911 67.0
CMS2_k127_324536_0 Protein of unknown function (DUF434) - - - 0.000000000000000000000000000000000000000005964 163.0
CMS2_k127_324536_1 Fumarase C-terminus K01678 - 4.2.1.2 0.0000000000000000000000000000000000000001505 154.0
CMS2_k127_3245601_0 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000003725 160.0
CMS2_k127_3245601_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000002129 154.0
CMS2_k127_3245601_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.00000000000000000000001961 103.0
CMS2_k127_325305_0 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001041 261.0
CMS2_k127_325305_1 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000008741 141.0
CMS2_k127_325305_2 PFAM CBS domain containing protein - - - 0.0000000000000000000000000003104 116.0
CMS2_k127_3260657_0 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000002022 106.0
CMS2_k127_3284129_0 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004992 286.0
CMS2_k127_3284129_1 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000001797 153.0
CMS2_k127_3316135_0 - K00960 - 2.7.7.6 0.0000000000001765 71.0
CMS2_k127_3327307_0 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001413 287.0
CMS2_k127_3327307_1 Glycogen synthase - - - 0.00000000000000000000000000000000000002442 145.0
CMS2_k127_3340057_0 bacterioferritin comigratory protein K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000001792 192.0
CMS2_k127_3340057_1 oxidoreductase activity - - - 0.0003634 51.0
CMS2_k127_3341407_0 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000000483 123.0
CMS2_k127_3341407_1 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000007995 88.0
CMS2_k127_3364347_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 5.769e-237 749.0
CMS2_k127_3372111_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 431.0
CMS2_k127_3372111_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000000000000000000000002045 166.0
CMS2_k127_337843_0 methyltransferase small K07579 - - 0.0000000000000000000000000000000000000000000000000000006559 198.0
CMS2_k127_337843_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000002657 187.0
CMS2_k127_337843_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000007152 59.0
CMS2_k127_3395844_0 Radical SAM K22227 - - 0.000000000000000000000000000000000000000000001663 170.0
CMS2_k127_3395844_1 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000006802 156.0
CMS2_k127_3395844_2 Belongs to the thioredoxin family K03671 - - 0.000000000000649 68.0
CMS2_k127_3414049_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 2.36e-196 622.0
CMS2_k127_3427134_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 418.0
CMS2_k127_3435352_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 6.221e-278 873.0
CMS2_k127_3435352_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 384.0
CMS2_k127_3435352_2 PFAM PP-loop - - - 0.0000000000000000000000002866 109.0
CMS2_k127_3439003_0 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000004591 194.0
CMS2_k127_3439003_1 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000005641 170.0
CMS2_k127_344505_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.734e-290 913.0
CMS2_k127_344505_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000000007704 218.0
CMS2_k127_344505_2 Glutaredoxin - - - 0.00000000000000000000000000000005789 127.0
CMS2_k127_344505_3 YHS domain - - - 0.000000000000000002269 84.0
CMS2_k127_3455573_0 DNA polymerase X family K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 477.0
CMS2_k127_3457747_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000009066 190.0
CMS2_k127_3481681_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 4.217e-196 625.0
CMS2_k127_3489318_0 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000124 226.0
CMS2_k127_3489318_1 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000005074 209.0
CMS2_k127_3489318_2 PFAM PRC-barrel domain - - - 0.000000000000000000007743 94.0
CMS2_k127_3489318_3 TIGRFAM drug resistance transporter, Bcr CflA subfamily K07552 - - 0.0000004763 53.0
CMS2_k127_3498326_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000001892 269.0
CMS2_k127_3507981_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000003753 243.0
CMS2_k127_3507981_1 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000002464 77.0
CMS2_k127_3511581_0 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 7.073e-292 909.0
CMS2_k127_3511581_1 FAD dependent oxidoreductase K16885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 425.0
CMS2_k127_351419_0 DEAD DEAH box helicase domain protein K10896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006502 533.0
CMS2_k127_3520829_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 355.0
CMS2_k127_3520829_1 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000004171 115.0
CMS2_k127_3520829_2 4Fe-4S binding domain K12143 - - 0.00000002173 61.0
CMS2_k127_3540717_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000216 240.0
CMS2_k127_3540717_1 Protein of unknown function DUF72 - - - 0.00000000000000001009 89.0
CMS2_k127_3542419_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 454.0
CMS2_k127_3542419_1 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000002825 104.0
CMS2_k127_3546603_0 Molybdopterin oxidoreductase Fe4S4 domain K00123,K00367,K00372,K08356 - 1.17.1.9,1.20.2.1,1.20.9.1,1.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 377.0
CMS2_k127_3559386_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K14392 - - 9.508e-216 678.0
CMS2_k127_3559386_1 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000009162 115.0
CMS2_k127_3559386_2 PFAM FecR protein - - - 0.00000000000004273 83.0
CMS2_k127_3564741_0 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000002144 238.0
CMS2_k127_3566628_0 - - - - 0.000000000000000000000000001803 115.0
CMS2_k127_3566628_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000003989 106.0
CMS2_k127_3571140_0 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 338.0
CMS2_k127_3571140_1 PFAM Binding-protein-dependent transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000001686 212.0
CMS2_k127_3630841_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 481.0
CMS2_k127_3691123_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 432.0
CMS2_k127_3691123_1 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000001788 139.0
CMS2_k127_3711179_0 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000007403 271.0
CMS2_k127_3716333_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 315.0
CMS2_k127_3732908_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000002559 227.0
CMS2_k127_37705_0 PFAM glutamate--cysteine ligase, GCS2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 309.0
CMS2_k127_37705_1 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000002271 143.0
CMS2_k127_3776195_0 COG0500 SAM-dependent methyltransferases K17462 - - 0.00000000000000000000000000000000000000006768 158.0
CMS2_k127_3776195_1 peptidyl-tyrosine sulfation - - - 0.0005948 42.0
CMS2_k127_3787626_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 304.0
CMS2_k127_3787626_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000001732 97.0
CMS2_k127_378776_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 529.0
CMS2_k127_378776_1 ATP citrate synthase activity K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 385.0
CMS2_k127_3793978_0 PFAM Ion transport protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 316.0
CMS2_k127_3793978_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K10536 - 3.5.3.12 0.0000000000000000002312 93.0
CMS2_k127_3826599_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009166 271.0
CMS2_k127_3826599_1 Peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000004628 90.0
CMS2_k127_385094_0 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000001019 198.0
CMS2_k127_385094_1 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.00000000000000000000000000000000008341 136.0
CMS2_k127_385094_2 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000005485 61.0
CMS2_k127_3876847_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000958 248.0
CMS2_k127_3881934_0 divalent heavy-metal cations transporter K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000267 228.0
CMS2_k127_3881934_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000005415 61.0
CMS2_k127_3881934_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0001475 44.0
CMS2_k127_3910096_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 463.0
CMS2_k127_3910096_1 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 328.0
CMS2_k127_391731_0 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001091 245.0
CMS2_k127_391731_1 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000002132 201.0
CMS2_k127_391731_2 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000552 106.0
CMS2_k127_391731_3 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000001091 93.0
CMS2_k127_3922319_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 388.0
CMS2_k127_3922319_1 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 288.0
CMS2_k127_3922319_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000001843 239.0
CMS2_k127_3922319_3 Acyltransferase family - - - 0.000000000000001823 87.0
CMS2_k127_3922319_4 - - - - 0.000000000002571 73.0
CMS2_k127_3922319_5 - - - - 0.000009252 51.0
CMS2_k127_3924510_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 404.0
CMS2_k127_3924510_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000003181 67.0
CMS2_k127_3928836_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 527.0
CMS2_k127_3928836_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 398.0
CMS2_k127_3928836_2 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000003598 243.0
CMS2_k127_3928836_3 PFAM TfuA domain protein, core - - - 0.0000000000000000000000000000000000000000000000000000000000000001057 229.0
CMS2_k127_3928836_4 Thioesterase superfamily K02614 - - 0.0000000000000000000000000000002093 127.0
CMS2_k127_3928836_5 - - - - 0.00000000000000000000000000001039 124.0
CMS2_k127_3928836_6 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.0000001017 57.0
CMS2_k127_3934799_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000000000000000000000000000000000000000000000003322 183.0
CMS2_k127_3934799_1 Histone deacetylase domain - - - 0.000000000000000000000000000000000000006686 152.0
CMS2_k127_3945321_0 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000405 196.0
CMS2_k127_3962054_0 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 562.0
CMS2_k127_3962054_1 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 437.0
CMS2_k127_3962054_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000007483 178.0
CMS2_k127_3962054_3 Lrp/AsnC ligand binding domain - - - 0.00000000008938 66.0
CMS2_k127_3969759_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 296.0
CMS2_k127_3969759_1 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.000000006902 59.0
CMS2_k127_3974328_0 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008821 461.0
CMS2_k127_3974328_1 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000004619 57.0
CMS2_k127_3976209_0 PFAM PilT protein domain protein K06865 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 324.0
CMS2_k127_398268_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 476.0
CMS2_k127_398268_1 PFAM ribosomal protein S8E K02995 GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.00000000000000000000000000000000000000008794 154.0
CMS2_k127_398268_2 Domain of unknown function (DUF1922) - - - 0.0000000009743 61.0
CMS2_k127_398268_3 PFAM thioesterase superfamily - - - 0.0004604 43.0
CMS2_k127_398457_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002247 289.0
CMS2_k127_3993396_0 Serine hydroxymethyltransferase K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 545.0
CMS2_k127_3993396_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000006501 203.0
CMS2_k127_3993396_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000008324 199.0
CMS2_k127_3993396_3 PFAM PUA domain containing protein K07398 - - 0.0000000000000000000000000000000000000000002839 162.0
CMS2_k127_3993727_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 409.0
CMS2_k127_3993727_1 - - - - 0.0000000007581 60.0
CMS2_k127_400007_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000002236 237.0
CMS2_k127_400007_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000795 89.0
CMS2_k127_4006193_0 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 409.0
CMS2_k127_401244_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.109e-307 959.0
CMS2_k127_401244_1 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 342.0
CMS2_k127_401244_2 Belongs to the group II decarboxylase family. MfnA subfamily K18933 - 4.1.1.11,4.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 311.0
CMS2_k127_4017187_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 610.0
CMS2_k127_4040498_0 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 360.0
CMS2_k127_404354_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006566 286.0
CMS2_k127_404354_1 Domain of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000294 243.0
CMS2_k127_404354_2 Fumarase C-terminus K01678 - 4.2.1.2 0.00000000000000000002545 95.0
CMS2_k127_4050578_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 310.0
CMS2_k127_4050578_1 cellular potassium ion transport K03499 - - 0.000000000000000000000000000000000000000000000000009341 186.0
CMS2_k127_4051158_0 TIGRFAM precorrin-3B C17-methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.000000000000000000000000001837 125.0
CMS2_k127_4055075_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 306.0
CMS2_k127_4055075_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000007014 148.0
CMS2_k127_4055075_2 protein conserved in archaea - - - 0.000000000000000000000000002367 113.0
CMS2_k127_4058118_0 histone deacetylase K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 299.0
CMS2_k127_4060500_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 478.0
CMS2_k127_4079082_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 617.0
CMS2_k127_4079082_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000004469 164.0
CMS2_k127_4098634_0 nucleoside recognition domain protein - - - 0.0000000000000000000000000000000000000000949 160.0
CMS2_k127_4100759_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 302.0
CMS2_k127_4100759_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000493 259.0
CMS2_k127_4100759_2 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000002941 179.0
CMS2_k127_4100759_3 binds to the 23S rRNA K02876 - - 0.0000000000000000000002307 100.0
CMS2_k127_4119833_0 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 473.0
CMS2_k127_4134223_0 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006923 328.0
CMS2_k127_4134223_1 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002964 253.0
CMS2_k127_4150900_0 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000001771 234.0
CMS2_k127_4150900_1 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000001871 118.0
CMS2_k127_4153334_0 PFAM GCN5-related N-acetyltransferase K03824 - - 0.0000000000000000000000000000000000000000001248 165.0
CMS2_k127_4153334_1 - - - - 0.000000000000000000000000000000000001648 141.0
CMS2_k127_4153334_2 Flavodoxin-like fold - - - 0.00000000000000000000000000008733 119.0
CMS2_k127_4153334_3 alkylhydroperoxidase like protein, AhpD family - - - 0.0000000000000000000000000007661 115.0
CMS2_k127_4163992_0 Iron-sulfur cluster-binding domain K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 465.0
CMS2_k127_4163992_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 327.0
CMS2_k127_4163992_2 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000502 256.0
CMS2_k127_4167595_0 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000004098 269.0
CMS2_k127_4167595_1 domain protein K01992,K06994 - - 0.000000000000000000000000000000000000000006138 160.0
CMS2_k127_4170118_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 426.0
CMS2_k127_4170118_1 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000007851 235.0
CMS2_k127_4170118_2 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000005887 195.0
CMS2_k127_4170118_3 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.0000000000000000000000000000000001101 140.0
CMS2_k127_4208974_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 434.0
CMS2_k127_4226179_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000003235 161.0
CMS2_k127_426241_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 404.0
CMS2_k127_426241_1 Nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000003807 204.0
CMS2_k127_427072_0 ATPases associated with a variety of cellular activities K00400 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 304.0
CMS2_k127_427072_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000546 150.0
CMS2_k127_4272422_0 shikimate kinase activity K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000001431 211.0
CMS2_k127_4272422_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000003846 187.0
CMS2_k127_4272422_2 chorismate mutase K04093 - 5.4.99.5 0.000000000000000005738 87.0
CMS2_k127_4283762_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006424 433.0
CMS2_k127_4283762_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000669 284.0
CMS2_k127_4283762_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000005623 204.0
CMS2_k127_4283762_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000001581 153.0
CMS2_k127_4290822_0 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000001607 199.0
CMS2_k127_4290822_1 Belongs to the MEMO1 family K06990 - - 0.000000000000001015 78.0
CMS2_k127_4319056_0 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000001537 192.0
CMS2_k127_4329560_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001107 271.0
CMS2_k127_4329560_1 Belongs to the bacterial solute-binding protein 3 family K02030 - - 0.00000000000013 84.0
CMS2_k127_4329560_2 Alkyl sulfatase dimerisation - - - 0.00000005049 54.0
CMS2_k127_4330898_0 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000001847 217.0
CMS2_k127_4330898_1 Uncharacterized protein domain (DUF2202) - - - 0.00000000000000000000000000003715 119.0
CMS2_k127_4357025_0 ATPase involved in replication control, Cdc46 Mcm family K10726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 351.0
CMS2_k127_4374283_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008125 253.0
CMS2_k127_4392773_0 beta-lactamase domain protein - - - 0.000008741 49.0
CMS2_k127_4406536_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001505 283.0
CMS2_k127_4412949_0 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000002415 214.0
CMS2_k127_4412949_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000006514 191.0
CMS2_k127_4412949_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000001147 185.0
CMS2_k127_4412949_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000000000000000000000000000000005564 164.0
CMS2_k127_4419111_0 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000000000000000000000000000002691 175.0
CMS2_k127_4419111_1 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000002361 111.0
CMS2_k127_4419111_2 May be involved in maturation of the 30S ribosomal subunit K02966 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0001499 45.0
CMS2_k127_4447936_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 356.0
CMS2_k127_4447936_1 COG1226 Kef-type K transport systems K10716 - - 0.000000000000000000000000000000000000000000000000000000000004651 216.0
CMS2_k127_4482648_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 1.178e-237 743.0
CMS2_k127_4482648_1 4Fe-4S dicluster domain - - - 0.0000000000000000006486 87.0
CMS2_k127_4492587_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 312.0
CMS2_k127_4492587_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000001091 127.0
CMS2_k127_4492587_2 cheY-homologous receiver domain - - - 0.00000000000000000000001395 105.0
CMS2_k127_4498660_0 Cellobiose phosphorylase K00702,K18675 - 2.4.1.20,2.4.1.280 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 352.0
CMS2_k127_4498660_1 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 285.0
CMS2_k127_4498660_2 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 0.0000000000004024 69.0
CMS2_k127_4531682_0 Parallel beta-helix repeat K07218 - - 0.0000000007021 64.0
CMS2_k127_4531682_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000005351 61.0
CMS2_k127_4545251_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 377.0
CMS2_k127_4545251_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 326.0
CMS2_k127_4545251_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000001834 90.0
CMS2_k127_4545251_11 Transcription factor Pcc1 K09741 - - 0.00000000000007494 74.0
CMS2_k127_4545251_12 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000007831 69.0
CMS2_k127_4545251_2 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 324.0
CMS2_k127_4545251_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 319.0
CMS2_k127_4545251_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001245 283.0
CMS2_k127_4545251_5 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009118 273.0
CMS2_k127_4545251_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000003423 125.0
CMS2_k127_4545251_7 binds to the 23S rRNA K02921 - - 0.00000000000000000000000000005513 118.0
CMS2_k127_4545251_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.000000000000000000000002485 109.0
CMS2_k127_4545251_9 RNA binding K07581 - - 0.000000000000000000008475 96.0
CMS2_k127_4548922_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 524.0
CMS2_k127_4548922_1 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 439.0
CMS2_k127_4559748_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 410.0
CMS2_k127_4559748_1 PFAM amino acid-binding ACT domain protein K06862 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 305.0
CMS2_k127_4559748_2 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 310.0
CMS2_k127_4559748_3 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 291.0
CMS2_k127_4559748_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000976 184.0
CMS2_k127_4559748_5 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000000000000000000000000001182 146.0
CMS2_k127_4559748_6 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.00000000000000000008979 93.0
CMS2_k127_4559748_7 Histone-like transcription factor (CBF/NF-Y) and archaeal histone - - - 0.000000000000001569 78.0
CMS2_k127_4559748_8 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000001977 67.0
CMS2_k127_456481_0 histidine kinase HAMP region domain protein K03406 - - 0.00000006661 64.0
CMS2_k127_457431_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 387.0
CMS2_k127_457431_1 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000000000000000004581 112.0
CMS2_k127_4576727_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 3.304e-227 718.0
CMS2_k127_4576727_1 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000008901 98.0
CMS2_k127_4576727_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000216 91.0
CMS2_k127_4576727_3 Radical SAM domain protein K07129 - - 0.000001371 51.0
CMS2_k127_4595634_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 402.0
CMS2_k127_4595634_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000002657 215.0
CMS2_k127_4595634_2 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000001432 207.0
CMS2_k127_4595646_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 324.0
CMS2_k127_4601376_0 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000000000000002721 200.0
CMS2_k127_4601376_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000006361 199.0
CMS2_k127_4601376_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000001243 142.0
CMS2_k127_4601376_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000007033 95.0
CMS2_k127_4637632_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 519.0
CMS2_k127_4638652_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 4.385e-199 630.0
CMS2_k127_4638652_1 RNA-binding protein (contains PUA domain) K07575 - - 0.00000000000000000000000000000000000002247 150.0
CMS2_k127_4638652_2 Stage II sporulation protein M - - - 0.0000000000000000000000000000191 126.0
CMS2_k127_4638652_3 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000000001947 113.0
CMS2_k127_4638652_4 binds to the 23S rRNA K02922 - - 0.00000000000000003181 81.0
CMS2_k127_4670198_0 Belongs to the citrate synthase family K01647 GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 547.0
CMS2_k127_4670198_1 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000009751 228.0
CMS2_k127_4672121_0 Homeodomain-like domain K06933 - - 0.0000000000000000000001634 103.0
CMS2_k127_4672121_1 CobQ/CobB/MinD/ParA nucleotide binding domain - - - 0.000000000000003212 76.0
CMS2_k127_4675978_0 Acetyl xylan esterase (AXE1) K06889 - - 0.00000000000000000000000000000000000000000000000000001681 196.0
CMS2_k127_4688882_0 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000002593 117.0
CMS2_k127_4688882_1 Universal stress protein family - - - 0.000000000000000000003097 100.0
CMS2_k127_4688882_2 - - - - 0.0000004792 57.0
CMS2_k127_4701360_0 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 338.0
CMS2_k127_4701360_1 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 300.0
CMS2_k127_4701360_2 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.000000000000000000000000000000000000000000003186 171.0
CMS2_k127_4701360_3 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000002911 106.0
CMS2_k127_4701360_4 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000001009 98.0
CMS2_k127_4737454_0 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000002556 184.0
CMS2_k127_4737454_1 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000000001851 166.0
CMS2_k127_4737454_2 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000006597 138.0
CMS2_k127_4753321_0 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 465.0
CMS2_k127_4753321_1 Citrate synthase, C-terminal domain K01648 - 2.3.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 353.0
CMS2_k127_4753321_2 - - - - 0.000000000000000001021 92.0
CMS2_k127_4757918_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 439.0
CMS2_k127_4765623_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000005455 217.0
CMS2_k127_4782630_0 SMART Tetratricopeptide domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001544 249.0
CMS2_k127_4782630_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000002206 113.0
CMS2_k127_4787542_0 membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000003628 198.0
CMS2_k127_4787542_1 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000006659 190.0
CMS2_k127_4787542_2 Methyltransferase type 11 - - - 0.0007318 42.0
CMS2_k127_4817430_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.143e-228 721.0
CMS2_k127_4829724_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 497.0
CMS2_k127_4829724_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 406.0
CMS2_k127_4836190_0 Transcriptional regulator - - - 0.0000000002407 64.0
CMS2_k127_4850350_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1539.0
CMS2_k127_4850350_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 317.0
CMS2_k127_4850350_2 PFAM 4Fe-4S - - - 0.00000000000000005888 91.0
CMS2_k127_4850350_3 COG3547 Transposase and inactivated derivatives - - - 0.00000000001071 69.0
CMS2_k127_4854981_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 291.0
CMS2_k127_4910933_0 PFAM dihydropteroate synthase, DHPS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001953 285.0
CMS2_k127_4910933_1 - - - - 0.00000000005176 72.0
CMS2_k127_4974365_0 COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) K00602 GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001165 276.0
CMS2_k127_4975694_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 3.774e-212 663.0
CMS2_k127_4975694_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008207 247.0
CMS2_k127_4975694_2 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000404 223.0
CMS2_k127_4975694_3 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000009288 209.0
CMS2_k127_4986769_0 TIGRFAM formate dehydrogenase, alpha subunit K00336,K05299 - 1.17.1.10,1.6.5.3 1.514e-247 779.0
CMS2_k127_4986769_1 PFAM formate nitrite transporter K21993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007266 273.0
CMS2_k127_4986769_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006504 273.0
CMS2_k127_4986773_0 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000101 221.0
CMS2_k127_4986773_1 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000006157 216.0
CMS2_k127_4986773_2 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000001205 191.0
CMS2_k127_4986773_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000008005 143.0
CMS2_k127_4986773_4 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000008603 70.0
CMS2_k127_4991299_0 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001869 289.0
CMS2_k127_4995511_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 418.0
CMS2_k127_4995511_1 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000006259 224.0
CMS2_k127_4995511_2 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000001887 197.0
CMS2_k127_4995511_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000004556 130.0
CMS2_k127_4995511_4 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000001257 121.0
CMS2_k127_5011300_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.365e-242 758.0
CMS2_k127_5022152_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 2.166e-212 674.0
CMS2_k127_5022152_1 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000001184 161.0
CMS2_k127_5038394_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 306.0
CMS2_k127_5038394_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000003001 213.0
CMS2_k127_50555_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 439.0
CMS2_k127_50555_1 Beta-eliminating lyase K13010 - 2.6.1.102 0.000000000000000144 81.0
CMS2_k127_5177317_0 Belongs to the DegT DnrJ EryC1 family K07806,K21337 - 2.6.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 306.0
CMS2_k127_5177317_10 Protein of unknown function (DUF616) - - - 0.0000000000000000000000000002596 123.0
CMS2_k127_5177317_11 - - - - 0.0000000000000000002503 98.0
CMS2_k127_5177317_12 Caudovirus prohead serine protease K06904 - - 0.000000000000000003082 98.0
CMS2_k127_5177317_13 - - - - 0.00000000000000008729 86.0
CMS2_k127_5177317_15 DNA binding - - - 0.000000002097 67.0
CMS2_k127_5177317_16 lipopolysaccharide 3-alpha-galactosyltransferase activity - - - 0.00000001186 65.0
CMS2_k127_5177317_18 Glycosyl transferases group 1 - - - 0.00000002143 67.0
CMS2_k127_5177317_2 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000001288 243.0
CMS2_k127_5177317_20 Protein conserved in bacteria K20444 - - 0.00000005773 62.0
CMS2_k127_5177317_21 HNH nucleases - - - 0.0000001844 59.0
CMS2_k127_5177317_22 Glycosyltransferase like family 2 K16649 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008378,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.4.1.287 0.000004354 59.0
CMS2_k127_5177317_23 Glycosyl transferase, family 2 K13000 - - 0.000006315 55.0
CMS2_k127_5177317_24 Glycosyl transferases group 1 - - - 0.0008368 51.0
CMS2_k127_5177317_25 - - - - 0.0008835 45.0
CMS2_k127_5177317_3 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.000000000000000000000000000000000000000000000000000000000000000006996 244.0
CMS2_k127_5177317_4 Phage capsid family - - - 0.000000000000000000000000000000000000000000000000000000000002605 226.0
CMS2_k127_5177317_5 Phage portal protein - - - 0.00000000000000000000000000000000000000000000000000000000002888 235.0
CMS2_k127_5177317_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000001201 179.0
CMS2_k127_5177317_7 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000009768 164.0
CMS2_k127_5177317_8 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 4.3.99.3 0.0000000000000000000000000000000000002886 147.0
CMS2_k127_5177317_9 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000001047 136.0
CMS2_k127_5179543_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 414.0
CMS2_k127_5179543_1 Permease - - - 0.000000000000000000000000000000000000008204 154.0
CMS2_k127_5183866_0 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 365.0
CMS2_k127_5213560_0 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000004852 139.0
CMS2_k127_5213560_1 AAA family ATPase, CDC48 subfamily K13525 - - 0.00000000000000308 79.0
CMS2_k127_5215251_0 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 323.0
CMS2_k127_5215251_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000305 138.0
CMS2_k127_5215251_2 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.0000000000000000000000000004343 119.0
CMS2_k127_5216373_0 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000003844 240.0
CMS2_k127_5216373_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000187 137.0
CMS2_k127_5216373_2 4Fe-4S dicluster domain K00171 - 1.2.7.1 0.0000000000000000000000000007058 114.0
CMS2_k127_5239541_0 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 400.0
CMS2_k127_5239541_1 indolepyruvate ferredoxin oxidoreductase, beta subunit K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000007523 181.0
CMS2_k127_5239541_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000002665 108.0
CMS2_k127_5248999_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 419.0
CMS2_k127_5254768_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 401.0
CMS2_k127_5254768_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000003293 186.0
CMS2_k127_5254768_2 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000005467 178.0
CMS2_k127_5254768_3 Protein of unknown function (DUF1614) - - - 0.00000005765 59.0
CMS2_k127_5260597_0 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000006588 184.0
CMS2_k127_5260597_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000001042 155.0
CMS2_k127_5267639_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 492.0
CMS2_k127_5269488_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001116 284.0
CMS2_k127_5269488_1 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000003708 201.0
CMS2_k127_5269488_2 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000002467 85.0
CMS2_k127_5306350_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 342.0
CMS2_k127_5306350_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004773 274.0
CMS2_k127_5322169_0 TROVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 346.0
CMS2_k127_5322169_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000009712 263.0
CMS2_k127_5322169_10 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000002283 67.0
CMS2_k127_5322169_11 single-stranded DNA binding K03111 - - 0.000005408 58.0
CMS2_k127_5322169_14 cellulose 1,4-beta-cellobiosidase activity K21449 - - 0.0005504 53.0
CMS2_k127_5322169_2 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000005893 178.0
CMS2_k127_5322169_3 - - - - 0.00000000000000000000000000001124 124.0
CMS2_k127_5322169_5 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000243 111.0
CMS2_k127_5322169_7 nuclear chromosome segregation - - - 0.00000000004886 77.0
CMS2_k127_5322169_8 - - - - 0.00000001096 61.0
CMS2_k127_5322169_9 - - - - 0.00000002042 65.0
CMS2_k127_5327462_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000113 169.0
CMS2_k127_5327462_1 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000002692 121.0
CMS2_k127_5327462_2 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000002396 85.0
CMS2_k127_5330241_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 260.0
CMS2_k127_5330241_1 PFAM Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000008743 170.0
CMS2_k127_5330995_0 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000009596 160.0
CMS2_k127_5330995_1 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000003437 162.0
CMS2_k127_5336308_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 606.0
CMS2_k127_5344141_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 299.0
CMS2_k127_5344141_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 287.0
CMS2_k127_5345672_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.605e-224 704.0
CMS2_k127_5345672_1 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000001191 163.0
CMS2_k127_5345672_2 tetratricopeptide repeat - - - 0.00000000000008951 78.0
CMS2_k127_5345672_3 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.00000003899 57.0
CMS2_k127_5355549_0 ABC-type transporter, periplasmic subunit family 3 K01489 - 3.5.4.5 0.00000000000000000000000000000000000000000000000004887 184.0
CMS2_k127_5382612_0 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000001084 132.0
CMS2_k127_5382612_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.0000007445 57.0
CMS2_k127_5408093_0 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000005495 192.0
CMS2_k127_5419618_0 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000687 269.0
CMS2_k127_5419618_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000007567 184.0
CMS2_k127_5419618_2 MacB-like periplasmic core domain K09808 - - 0.00000000001924 70.0
CMS2_k127_5427574_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.585e-306 949.0
CMS2_k127_5427574_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 366.0
CMS2_k127_5433032_0 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001042 289.0
CMS2_k127_5450355_0 TIGRFAM UbiD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 481.0
CMS2_k127_5450355_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000212 283.0
CMS2_k127_5460092_0 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000001673 121.0
CMS2_k127_5460092_1 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000002389 73.0
CMS2_k127_546564_0 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004245 271.0
CMS2_k127_546564_1 Belongs to the precorrin methyltransferase family K02303,K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000028 141.0
CMS2_k127_5479440_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 563.0
CMS2_k127_5479440_1 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000001492 188.0
CMS2_k127_5479440_2 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000001839 183.0
CMS2_k127_5479440_3 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000001265 166.0
CMS2_k127_5479440_4 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.000000000000000000000000000000000005372 144.0
CMS2_k127_5479440_5 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000003319 132.0
CMS2_k127_5479440_6 methanogenesis marker protein 7 - - - 0.0000000000003868 70.0
CMS2_k127_5484458_0 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 392.0
CMS2_k127_5494774_0 Belongs to the ompA family - - - 0.0000000000000000000000000000000000002248 156.0
CMS2_k127_5494774_1 arabinan catabolic process - - - 0.00000000000000000000000006394 121.0
CMS2_k127_5498803_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005044 409.0
CMS2_k127_5498803_1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.000000000000000000007822 96.0
CMS2_k127_5519711_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 429.0
CMS2_k127_5519711_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 326.0
CMS2_k127_5519711_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004162 281.0
CMS2_k127_5519711_3 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000003032 230.0
CMS2_k127_5519711_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.0000000000000000000000000000000000000005858 151.0
CMS2_k127_5519711_5 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000004307 98.0
CMS2_k127_5559328_0 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 563.0
CMS2_k127_5559328_1 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000007538 150.0
CMS2_k127_5577928_0 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000182 139.0
CMS2_k127_5577928_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.0000000000000000000000000000000002592 151.0
CMS2_k127_5578502_0 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000225 213.0
CMS2_k127_5578502_1 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000004763 168.0
CMS2_k127_5581331_0 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 329.0
CMS2_k127_5581331_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000434 198.0
CMS2_k127_5581331_2 Gar1/Naf1 RNA binding region K07569 - - 0.00000000002922 67.0
CMS2_k127_5597789_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 4.861e-216 682.0
CMS2_k127_5597789_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000003934 243.0
CMS2_k127_5600890_0 PFAM ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 387.0
CMS2_k127_5600890_1 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002521 239.0
CMS2_k127_5600890_2 methylisocitrate lyase activity K03417,K20454 - 4.1.3.30,4.1.3.32 0.0000000000000000000000000000003698 123.0
CMS2_k127_5610766_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 449.0
CMS2_k127_5610766_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000654 220.0
CMS2_k127_5622983_0 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001179 258.0
CMS2_k127_5622983_1 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000001125 86.0
CMS2_k127_5627277_0 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 410.0
CMS2_k127_5652901_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 326.0
CMS2_k127_5652901_1 DNA photolyase activity - - - 0.0000000000000000000000000002277 128.0
CMS2_k127_5652901_2 tRNA wobble adenosine to inosine editing - - - 0.00000000000000000000000003903 115.0
CMS2_k127_5652901_3 protein homooligomerization - - - 0.000000000000000000000268 108.0
CMS2_k127_5652901_4 DNA (cytosine-5-)-methyltransferase activity - - - 0.00000000000000002149 89.0
CMS2_k127_5652901_6 metal-binding protein - - - 0.00006766 51.0
CMS2_k127_5652901_7 Transcriptional regulator K04066 - - 0.0009112 51.0
CMS2_k127_5665270_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003221 259.0
CMS2_k127_5665270_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000001243 216.0
CMS2_k127_5667108_0 ABC transporter K02028,K17076 - 3.6.3.21 0.00000000000000000000000000000000000000000004347 171.0
CMS2_k127_5667108_1 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000003349 96.0
CMS2_k127_5669801_0 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001141 274.0
CMS2_k127_5669801_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000002575 191.0
CMS2_k127_5669801_2 - - - - 0.0000000000000000000005153 103.0
CMS2_k127_5673851_0 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 290.0
CMS2_k127_5673851_1 Belongs to the UPF0285 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001037 276.0
CMS2_k127_5673851_2 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000000147 191.0
CMS2_k127_5673851_3 Pfam:DUF552 K09152 - - 0.00000000000000000000000004641 111.0
CMS2_k127_5686847_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 330.0
CMS2_k127_5686847_1 periplasmic K07218 - - 0.0000000003147 73.0
CMS2_k127_5709652_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 535.0
CMS2_k127_5709652_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000001074 114.0
CMS2_k127_5709652_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000000000121 109.0
CMS2_k127_5723661_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 312.0
CMS2_k127_5725996_0 COG3387 Glucoamylase and related glycosyl hydrolases - - - 6.148e-244 769.0
CMS2_k127_5725996_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 292.0
CMS2_k127_5725996_2 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000755 245.0
CMS2_k127_5727200_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000313 181.0
CMS2_k127_5727200_1 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000000000000005913 108.0
CMS2_k127_576627_0 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000001963 236.0
CMS2_k127_576627_1 Transcriptional regulator K07108 - - 0.000000000000000000000000031 111.0
CMS2_k127_5767320_0 PFAM SufBD protein K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 396.0
CMS2_k127_5767320_1 ABC transporter K09013 - - 0.000000000000000000000000000000000000000005114 157.0
CMS2_k127_5807630_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 614.0
CMS2_k127_5807630_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000002033 206.0
CMS2_k127_5838967_0 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000008314 239.0
CMS2_k127_5838967_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000004215 148.0
CMS2_k127_5841615_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K22167 - 1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 461.0
CMS2_k127_5841615_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K22161 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 447.0
CMS2_k127_5841615_2 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 332.0
CMS2_k127_5841615_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K22166 - 1.5.98.3 0.0000000000000000000000000000000009921 134.0
CMS2_k127_5841615_4 4Fe-4S dicluster domain K22164 - 1.5.98.3 0.000000000000000000000004545 109.0
CMS2_k127_5841615_5 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000001334 73.0
CMS2_k127_5868439_0 efflux protein, MATE family - - - 0.00000000000000000003302 98.0
CMS2_k127_5868439_1 MatE - - - 0.00000001397 59.0
CMS2_k127_5870744_0 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000001683 263.0
CMS2_k127_5870744_1 methyltransferase activity K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000000000004815 186.0
CMS2_k127_5870744_2 Pas domain - - - 0.0001036 50.0
CMS2_k127_5874847_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 428.0
CMS2_k127_5874847_1 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007523 265.0
CMS2_k127_5874847_2 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000001415 235.0
CMS2_k127_5874847_3 Putative Fe-S cluster K11260 - - 0.00000000000000000000000000000000000000000000000000000001208 201.0
CMS2_k127_5874847_4 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.0000000000000000000000000006838 117.0
CMS2_k127_587912_0 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001236 293.0
CMS2_k127_5881857_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000001128 188.0
CMS2_k127_5901247_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 342.0
CMS2_k127_5901247_1 queuosine salvage K09125 - - 0.00000000000000000000000000000008512 134.0
CMS2_k127_5911380_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 8.127e-202 634.0
CMS2_k127_5911380_1 - - - - 0.00002139 53.0
CMS2_k127_5944001_0 NADH ubiquinone oxidoreductase, NADH-binding K00124,K00335,K18331 - 1.12.1.3,1.6.5.3 1.247e-266 837.0
CMS2_k127_5944001_1 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000001213 188.0
CMS2_k127_5944001_2 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000008721 173.0
CMS2_k127_5972160_0 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006604 552.0
CMS2_k127_6015976_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000001411 194.0
CMS2_k127_6023747_0 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001509 255.0
CMS2_k127_6023747_1 PHP C-terminal domain protein - - - 0.000001235 51.0
CMS2_k127_6026448_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 381.0
CMS2_k127_603107_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 548.0
CMS2_k127_603107_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 485.0
CMS2_k127_603107_2 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 286.0
CMS2_k127_6032981_0 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000000002372 205.0
CMS2_k127_6032981_1 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000001289 168.0
CMS2_k127_6073896_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000002028 223.0
CMS2_k127_6084546_0 ATPases associated with a variety of cellular activities K00400 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 312.0
CMS2_k127_608574_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 479.0
CMS2_k127_612054_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 394.0
CMS2_k127_612054_1 Bifunctional nuclease K08999 - - 0.0003405 46.0
CMS2_k127_6126914_0 COG0464 ATPases of the AAA class K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 589.0
CMS2_k127_6126914_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 376.0
CMS2_k127_6168234_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008124 367.0
CMS2_k127_6168234_1 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000003377 107.0
CMS2_k127_6195528_0 PFAM Aldehyde dehydrogenase K22187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 292.0
CMS2_k127_6195528_1 Aminotransferase class-III K00823,K00836 - 2.6.1.19,2.6.1.76 0.0000000000000000000000000000000000000000004696 161.0
CMS2_k127_6209076_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 287.0
CMS2_k127_6241444_0 GXGXG motif K00202 - 1.2.7.12 0.0000000000004349 79.0
CMS2_k127_6241444_1 ATPase associated with various cellular activities - - - 0.0000000000008517 79.0
CMS2_k127_6243158_0 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000002204 200.0
CMS2_k127_6243158_1 Protein of unknown function DUF86 - - - 0.00000000000000001867 84.0
CMS2_k127_6243158_2 Protein of unknown function DUF86 - - - 0.0000000000000003992 79.0
CMS2_k127_6246181_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 356.0
CMS2_k127_6246181_1 Uncharacterized conserved protein (DUF2299) - - - 0.00000000000000000000000000000000006566 138.0
CMS2_k127_6246181_2 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.000000000000000000000000002347 115.0
CMS2_k127_6255039_0 oxidoreductase activity - - - 0.000000000000003003 87.0
CMS2_k127_6261036_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 393.0
CMS2_k127_6261036_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000002852 219.0
CMS2_k127_6274304_0 CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000000000000002035 185.0
CMS2_k127_6274304_1 nuclease - - - 0.000000000000000000000000000000000000000000349 162.0
CMS2_k127_6274304_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000008987 143.0
CMS2_k127_6276196_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000008895 261.0
CMS2_k127_6276196_1 SpoVT / AbrB like domain - - - 0.000000000000000000000001163 108.0
CMS2_k127_6289759_0 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001179 253.0
CMS2_k127_6289759_1 Radical SAM domain protein - - - 0.0008835 45.0
CMS2_k127_6349262_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 435.0
CMS2_k127_6349262_1 Filamentation induced by cAMP protein fic - - - 0.0000000000001692 72.0
CMS2_k127_6349262_2 phosphoesterases, related to the Icc protein - - - 0.00000000000111 75.0
CMS2_k127_6358467_0 Belongs to the CarB family K01955 - 6.3.5.5 5.16e-287 889.0
CMS2_k127_6362959_0 Histidine Phosphotransfer domain - - - 0.0000000000000000000000000000000000000000000000000000000000001666 218.0
CMS2_k127_6365939_0 Transcriptional regulator, TrmB - - - 0.0000000000000000000008535 97.0
CMS2_k127_6369497_0 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000004817 144.0
CMS2_k127_6369497_1 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000191 116.0
CMS2_k127_6369497_2 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000004452 113.0
CMS2_k127_6369497_3 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000001372 104.0
CMS2_k127_6376396_0 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 350.0
CMS2_k127_6376396_1 Chagasin family peptidase inhibitor I42 - - - 0.0001969 49.0
CMS2_k127_641058_0 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004727 245.0
CMS2_k127_641058_1 AN1-like Zinc finger K07059 - - 0.00000000000000000000000000000000000000002374 162.0
CMS2_k127_6429336_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 367.0
CMS2_k127_6429336_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000001964 126.0
CMS2_k127_645775_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 292.0
CMS2_k127_645775_1 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002262 278.0
CMS2_k127_6458454_0 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000000000746 248.0
CMS2_k127_6458454_1 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000002567 87.0
CMS2_k127_647028_0 Protein of unknown function (DUF460) K09150 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 400.0
CMS2_k127_647028_1 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000000000000000000002893 145.0
CMS2_k127_6501576_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000033 145.0
CMS2_k127_6501576_1 Domain of unknown function - - - 0.0000000000000000000002196 99.0
CMS2_k127_6501576_2 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.00001053 55.0
CMS2_k127_6514367_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 399.0
CMS2_k127_6514367_1 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000006006 261.0
CMS2_k127_6514930_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 361.0
CMS2_k127_6514930_1 PFAM GTP-binding protein HSR1-related K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 305.0
CMS2_k127_6514930_2 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000003538 138.0
CMS2_k127_6514930_3 Zn-ribbon containing protein K07163 - - 0.00000000000000000008638 95.0
CMS2_k127_6514930_4 Mo-molybdopterin cofactor metabolic process K03753 - - 0.000004629 49.0
CMS2_k127_6525978_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 478.0
CMS2_k127_6525978_1 Belongs to the 5'-nucleotidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004346 269.0
CMS2_k127_6555547_0 domain, Protein K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007908 485.0
CMS2_k127_6561994_0 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000001728 231.0
CMS2_k127_6561994_1 Protein of unknown function (DUF357) K09728 - - 0.00000000000000000001535 94.0
CMS2_k127_6561994_2 - - - - 0.0000009008 53.0
CMS2_k127_6568257_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000002958 201.0
CMS2_k127_6568257_1 Pentapeptide repeats (9 copies) - - - 0.00001001 55.0
CMS2_k127_6574173_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 455.0
CMS2_k127_6574173_1 PFAM Exonuclease VII small subunit K03602 - 3.1.11.6 0.000000000007246 67.0
CMS2_k127_657612_0 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 613.0
CMS2_k127_657612_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000003143 161.0
CMS2_k127_658615_0 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000001887 247.0
CMS2_k127_658615_1 PFAM Class II Aldolase K01628 - 4.1.2.17 0.00000000000000000001369 95.0
CMS2_k127_6604970_0 PFAM Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004142 284.0
CMS2_k127_6610054_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 3.228e-228 721.0
CMS2_k127_6610054_1 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000000000000000000000000000838 187.0
CMS2_k127_6610054_2 Integral membrane protein TerC family K05794 - - 0.000001773 51.0
CMS2_k127_6610969_0 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 343.0
CMS2_k127_6610969_1 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 317.0
CMS2_k127_6610969_2 anaerobic cobalamin biosynthetic process K02190 - 4.99.1.3 0.00009747 47.0
CMS2_k127_6628907_0 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000002526 259.0
CMS2_k127_6628907_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000688 141.0
CMS2_k127_6639903_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 402.0
CMS2_k127_6639903_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000005622 264.0
CMS2_k127_6639903_2 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000000001416 183.0
CMS2_k127_6639903_3 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000000000000000007019 173.0
CMS2_k127_6639903_4 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.000000000000000000000000000000000000001237 154.0
CMS2_k127_6641762_0 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 326.0
CMS2_k127_6641762_1 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000000001917 141.0
CMS2_k127_6648634_0 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000001061 113.0
CMS2_k127_6648634_1 heterodisulfide reductase K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000003463 109.0
CMS2_k127_6654197_0 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 490.0
CMS2_k127_6654197_1 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000004402 198.0
CMS2_k127_6657601_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 385.0
CMS2_k127_6672653_0 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000002151 143.0
CMS2_k127_6672653_1 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000004008 144.0
CMS2_k127_6684791_0 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 499.0
CMS2_k127_6684791_1 Nitrogen regulatory protein P-II K04751 - - 0.00000000000000000000000001508 113.0
CMS2_k127_6697761_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000005454 154.0
CMS2_k127_6697761_1 ribonuclease activity - - - 0.000000000000001979 81.0
CMS2_k127_6697761_2 dephospho-CoA kinase activity - - - 0.0000000001163 64.0
CMS2_k127_6707894_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 471.0
CMS2_k127_6707894_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000002305 117.0
CMS2_k127_6735734_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 2.403e-246 774.0
CMS2_k127_6735734_1 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000000003383 237.0
CMS2_k127_6735734_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000002846 106.0
CMS2_k127_6735734_3 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00001434 48.0
CMS2_k127_6773787_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009596 455.0
CMS2_k127_6773787_1 PFAM ABC transporter related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 332.0
CMS2_k127_6773787_2 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000004431 210.0
CMS2_k127_6775466_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009952 395.0
CMS2_k127_6775466_1 Calcineurin-like phosphoesterase - - - 0.000801 49.0
CMS2_k127_6788011_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 354.0
CMS2_k127_6788011_1 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000005303 142.0
CMS2_k127_6811042_0 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 327.0
CMS2_k127_6811042_1 Radical SAM ThiC family K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000005176 250.0
CMS2_k127_681802_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 582.0
CMS2_k127_681802_1 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000001609 240.0
CMS2_k127_681802_2 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000000003388 109.0
CMS2_k127_681802_3 Belongs to the UPF0218 family K09735 - - 0.000000000000000000003162 98.0
CMS2_k127_681802_4 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000006171 87.0
CMS2_k127_6818064_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 2.568e-237 745.0
CMS2_k127_6818064_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 285.0
CMS2_k127_6818064_2 Protein of unknown function (DUF1699) - - - 0.00000000000000000002653 91.0
CMS2_k127_68300_0 metal ion binding - - - 0.0000000000000000000000002071 113.0
CMS2_k127_68300_1 Belongs to the UPF0235 family K09131 - - 0.000000000000000005302 87.0
CMS2_k127_68300_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.000000001123 61.0
CMS2_k127_6839557_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 4.909e-200 635.0
CMS2_k127_6839557_1 NhaP-type Na H and K H - - - 0.000000000000000000000000000000000000000000000003933 179.0
CMS2_k127_6839557_2 Stage II sporulation protein M K06384 - - 0.00000000000000000000000000001099 125.0
CMS2_k127_6843980_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 358.0
CMS2_k127_6843980_1 membrane - - - 0.0000000000000000000000000002914 121.0
CMS2_k127_684523_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001008 271.0
CMS2_k127_6849907_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 414.0
CMS2_k127_6849907_1 Inorganic pyrophosphatase K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 311.0
CMS2_k127_6849907_2 HTH-type transcriptional regulatory protein K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 294.0
CMS2_k127_6849907_3 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.0000000000000000000000000000000000000000000000000000000000000002207 227.0
CMS2_k127_6849907_4 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000001172 157.0
CMS2_k127_6884298_0 Necessary for normal cell division and for the maintenance of normal septation - - - 0.0000000000000000000000000000000000000000000000000000000001336 209.0
CMS2_k127_6931154_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 297.0
CMS2_k127_6931154_1 Belongs to the MCM family K10726 - - 0.000000000000005915 77.0
CMS2_k127_6963508_0 Bifunctional nuclease K08999 - - 0.0000000000000000000000000006391 116.0
CMS2_k127_6973087_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 5.365e-198 625.0
CMS2_k127_6973087_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002348 285.0
CMS2_k127_6988291_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 407.0
CMS2_k127_6988291_1 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000000000000000000000001546 228.0
CMS2_k127_6988291_2 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000001505 109.0
CMS2_k127_6988291_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.000000000000000000002493 99.0
CMS2_k127_6988291_4 structural constituent of ribosome K02924 - - 0.0000000000001318 72.0
CMS2_k127_6988291_5 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.0000000000009018 70.0
CMS2_k127_6993406_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 398.0
CMS2_k127_7009389_0 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000002308 146.0
CMS2_k127_7009389_1 Dodecin K09165 - - 0.0000000000000000000006028 96.0
CMS2_k127_7010900_0 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000086 186.0
CMS2_k127_7010900_1 Protein of unknown function (DUF2953) - - - 0.0000000000003611 76.0
CMS2_k127_7014692_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 412.0
CMS2_k127_7014692_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 404.0
CMS2_k127_7014692_2 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009034 330.0
CMS2_k127_7014692_3 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000005734 138.0
CMS2_k127_7014692_4 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000002063 135.0
CMS2_k127_7042465_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 366.0
CMS2_k127_7042465_1 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000001867 102.0
CMS2_k127_7042465_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000005141 97.0
CMS2_k127_7042465_3 Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP K01990 - - 0.0006972 44.0
CMS2_k127_7064632_0 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000573 183.0
CMS2_k127_7067924_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 397.0
CMS2_k127_7067924_1 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000002716 265.0
CMS2_k127_7067924_2 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000003792 166.0
CMS2_k127_7068364_0 acid binding OB-fold tRNA helicase-type K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001363 253.0
CMS2_k127_7068364_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000004127 48.0
CMS2_k127_7080290_0 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000001265 196.0
CMS2_k127_7080290_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000004152 184.0
CMS2_k127_7080290_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.000000000000000000000000000000000006077 140.0
CMS2_k127_7087301_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 486.0
CMS2_k127_7087301_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 396.0
CMS2_k127_7087301_2 - - - - 0.0000000000000000000006205 98.0
CMS2_k127_7087301_3 Nitrite and sulphite reductase 4Fe-4S domain K21816 - 1.8.98.3 0.00000006674 57.0
CMS2_k127_714411_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 553.0
CMS2_k127_718045_0 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000001542 177.0
CMS2_k127_718045_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000003684 115.0
CMS2_k127_718045_2 methyltransferase - - - 0.00000000000008201 81.0
CMS2_k127_738614_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 3.98e-246 767.0
CMS2_k127_738614_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 1.643e-212 676.0
CMS2_k127_738874_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005108 345.0
CMS2_k127_738874_1 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000000000000009961 228.0
CMS2_k127_738874_2 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000006468 218.0
CMS2_k127_738874_3 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000004557 161.0
CMS2_k127_738874_4 - - - - 0.000000000000000000000000000000000001905 145.0
CMS2_k127_759466_0 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 498.0
CMS2_k127_759466_1 RNA ligase K07468 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 364.0
CMS2_k127_759466_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000005825 128.0
CMS2_k127_820757_0 Histone deacetylase domain - - - 9.73e-203 638.0
CMS2_k127_820757_1 Hydantoinase/oxoprolinase N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 436.0
CMS2_k127_829057_0 Methanogenesis marker protein 8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 328.0
CMS2_k127_829057_1 Glycosyltransferase 28 domain - - - 0.000000000000000000000000000000000000000000000003032 176.0
CMS2_k127_829057_2 Functions in trans to edit the amino acid moiety from K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000004588 57.0
CMS2_k127_83077_0 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000003396 173.0
CMS2_k127_833188_0 PFAM PP-loop domain protein - - - 0.0000000000000000001675 94.0
CMS2_k127_841307_0 PFAM Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000000001404 154.0
CMS2_k127_841307_1 RDD family - - - 0.00000000000000000000000000000002969 130.0
CMS2_k127_841307_2 - - - - 0.00009953 48.0
CMS2_k127_84178_0 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 1.712e-228 714.0
CMS2_k127_84178_1 PFAM Glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 526.0
CMS2_k127_845584_0 ABC transporter, ATP-binding protein K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001532 263.0
CMS2_k127_845584_1 extracellular matrix structural constituent - - - 0.00000000000000000000000000005618 129.0
CMS2_k127_845584_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000006554 82.0
CMS2_k127_855552_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 425.0
CMS2_k127_855552_1 endonuclease exonuclease phosphatase K07004 - - 0.00002557 46.0
CMS2_k127_857809_0 Saccharopine dehydrogenase K00290 - 1.5.1.7 0.000000000000000000000000000131 129.0
CMS2_k127_869949_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 575.0
CMS2_k127_869949_1 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000001384 266.0
CMS2_k127_869949_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000001436 160.0
CMS2_k127_880459_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 601.0
CMS2_k127_880459_1 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000008381 216.0
CMS2_k127_888078_0 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000002 191.0
CMS2_k127_888078_1 Protein of unknown function (DUF424) K09148 - - 0.0002231 46.0
CMS2_k127_88885_0 DGC domain - - - 0.000000000000000000000002662 106.0
CMS2_k127_88885_1 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000004736 102.0
CMS2_k127_890739_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 376.0
CMS2_k127_890739_1 in RNase L inhibitor, RLI K06174 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 351.0
CMS2_k127_890739_2 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000006858 211.0
CMS2_k127_890739_3 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000009513 113.0
CMS2_k127_890739_4 RNase L inhibitor, RLI - - - 0.0000000000000000000001064 104.0
CMS2_k127_893663_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000005083 253.0
CMS2_k127_916287_0 Peptidase inhibitor I9 K17734 - - 0.000000000000000000000007913 110.0
CMS2_k127_916287_1 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000002464 98.0
CMS2_k127_927381_0 Tex-like protein N-terminal domain K06959 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 596.0
CMS2_k127_927584_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 453.0
CMS2_k127_927584_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000001075 215.0
CMS2_k127_945312_0 flagellar motor switch protein K02410 GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009052 474.0
CMS2_k127_945312_1 flagellar assembly protein FliH K02411 - - 0.000000000000000000000000006907 119.0
CMS2_k127_94983_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 447.0
CMS2_k127_94983_1 nuclease of the RecB family - - - 0.0000002924 53.0
CMS2_k127_963434_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 382.0
CMS2_k127_963434_1 Papain family cysteine protease K14647 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001413 271.0
CMS2_k127_963434_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000204 224.0
CMS2_k127_963434_3 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.00004472 57.0
CMS2_k127_989643_0 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000004646 235.0
CMS2_k127_989643_1 COG0668 Small-conductance mechanosensitive channel K16052 - - 0.0000000000000000000000000000000000000000000000000000343 197.0
CMS2_k127_989643_2 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.00000000000000000000000000001498 121.0
CMS2_k127_993948_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000001791 224.0
CMS2_k127_993948_1 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0000000000000000000000000000000000000000000000004471 184.0
CMS2_k127_993951_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 499.0