Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K03557
-
-
0.00000000000000000000000000000000000000001883
155.0
CMS2_k127_1110105_146
protein conserved in bacteria
K11022
-
-
0.00000000000000000000000000000000000000007501
153.0
CMS2_k127_1110105_147
Preprotein translocase subunit YajC
K03210
-
-
0.00000000000000000000000000000000000009567
144.0
CMS2_k127_1110105_148
Belongs to the HesB IscA family
K05997,K13628
-
-
0.0000000000000000000000000000000000002832
143.0
CMS2_k127_1110105_149
polysaccharide deacetylase
-
-
-
0.00000000000000000000000000000000002943
143.0
CMS2_k127_1110105_15
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01657
-
4.1.3.27
1.49e-256
797.0
CMS2_k127_1110105_150
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated
-
-
-
0.000000000000000000000000000001833
134.0
CMS2_k127_1110105_154
Pkd domain containing protein
-
-
-
0.000000000000000000000000000009671
134.0
CMS2_k127_1110105_156
Cyclic nucleotide-monophosphate binding domain
-
-
-
0.000000000000000000000000000989
118.0
CMS2_k127_1110105_157
lipopolysaccharide biosynthesis protein
-
-
-
0.000000000000000000000000001128
124.0
CMS2_k127_1110105_158
-
-
-
-
0.000000000000000000000000005843
112.0
CMS2_k127_1110105_159
-
-
-
-
0.000000000000000000000000007478
116.0
CMS2_k127_1110105_16
An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
K01961
-
6.3.4.14,6.4.1.2
4.583e-247
767.0
CMS2_k127_1110105_160
DUF218 domain
-
-
-
0.000000000000000000000000009695
119.0
CMS2_k127_1110105_161
Acetyltransferase (GNAT) domain
-
-
-
0.00000000000000000000000008196
121.0
CMS2_k127_1110105_162
ABC transporter substrate binding protein
K01989
-
-
0.0000000000000000000000007498
115.0
CMS2_k127_1110105_163
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.00000000000000000000001066
109.0
CMS2_k127_1110105_164
Phosphopantetheine attachment site
-
-
-
0.00000000000000000000003578
101.0
CMS2_k127_1110105_165
pathogenesis
-
-
-
0.000000000000000000002768
101.0
CMS2_k127_1110105_166
-
-
-
-
0.00000000000000000006223
93.0
CMS2_k127_1110105_167
Transposase IS200 like
-
-
-
0.0000000000000000008461
91.0
CMS2_k127_1110105_168
Fe-S protein
K06938
-
-
0.0000000000000003363
80.0
CMS2_k127_1110105_169
Cbb3-type cytochrome oxidase component FixQ
K00407
-
-
0.00000000000002518
75.0
CMS2_k127_1110105_17
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
3.261e-244
760.0
CMS2_k127_1110105_170
Outer membrane efflux protein
-
-
-
0.00000000000006227
74.0
CMS2_k127_1110105_172
Cytochrome oxidase maturation protein
-
-
-
0.000000001235
61.0
CMS2_k127_1110105_173
-
-
-
-
0.000000001528
70.0
CMS2_k127_1110105_174
Serine aminopeptidase, S33
-
-
-
0.000000009016
66.0
CMS2_k127_1110105_176
Protein of unknown function (DUF3592)
-
-
-
0.00001612
52.0
CMS2_k127_1110105_178
DnaJ molecular chaperone homology domain
-
-
-
0.0001109
53.0
CMS2_k127_1110105_18
Tetratricopeptide repeat
-
-
-
6.513e-239
753.0
CMS2_k127_1110105_19
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions
K21071
-
2.7.1.11,2.7.1.90
1.355e-227
711.0
CMS2_k127_1110105_2
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
K01952
-
6.3.5.3
0.0
2023.0
CMS2_k127_1110105_20
Belongs to the GARS family
K01945
-
6.3.4.13
1.438e-224
701.0
CMS2_k127_1110105_21
Histidine kinase
K20972,K20973
-
2.7.13.3
1.753e-224
728.0
CMS2_k127_1110105_22
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
K04084
-
1.8.1.8
3.282e-217
692.0
CMS2_k127_1110105_23
COG0464 ATPases of the AAA class
-
-
-
2.787e-216
680.0
CMS2_k127_1110105_24
COG2217 Cation transport ATPase
K01533
-
3.6.3.4
1.975e-212
689.0
CMS2_k127_1110105_25
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
1.123e-209
655.0
CMS2_k127_1110105_26
COG1629 Outer membrane receptor proteins, mostly Fe transport
K02014
-
-
2.798e-209
674.0
CMS2_k127_1110105_27
TonB-dependent receptor
K02014
-
-
7.357e-209
669.0
CMS2_k127_1110105_28
TonB dependent receptor
-
-
-
5.286e-208
669.0
CMS2_k127_1110105_29
histidyl-tRNA synthetase
K01892
-
6.1.1.21
2.402e-207
652.0
CMS2_k127_1110105_3
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
1.491e-195
619.0
CMS2_k127_1110105_33
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18989
-
-
0.0
1286.0
CMS2_k127_1110105_40
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Type I site-specific restriction-modification system R (restriction) subunit and related helicases
K01153
-
3.1.21.3
0.0
1271.0
CMS2_k127_1112240_1
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02621
-
-
0.0
1245.0
CMS2_k127_1112240_10
ATPase components of ABC transporters with duplicated ATPase domains
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
3.009e-284
885.0
CMS2_k127_1112240_130
3'-to-5' exoribonuclease specific for small oligoribonucleotides
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
COG2076 Membrane transporters of cations and cationic drugs
K11741
-
-
0.0000000000000000000000000000000000000001785
152.0
CMS2_k127_1112240_172
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
K03666
-
-
0.000000000000000000000000000000000000006368
146.0
CMS2_k127_1112240_173
response to oxidative stress
-
-
-
0.00000000000000000000000000000000000005881
148.0
CMS2_k127_1112240_174
Protein of unknown function (DUF805)
-
-
-
0.0000000000000000000000000000000000008689
147.0
CMS2_k127_1112240_175
of membrane protease
K07340
-
-
0.00000000000000000000000000000000003568
139.0
CMS2_k127_1112240_177
Protein of unknown function (DUF2750)
-
-
-
0.00000000000000000000000000000005752
128.0
CMS2_k127_1112240_178
Serine/threonine phosphatases, family 2C, catalytic domain
Specifically methylates the ribose of guanosine 2251 in 23S rRNA
K03218
-
2.1.1.185
0.000000000000000000000000005366
116.0
CMS2_k127_1112240_186
-
-
-
-
0.000000000000000000000000009001
118.0
CMS2_k127_1112240_187
-
-
-
-
0.00000000000000000000000009393
122.0
CMS2_k127_1112240_188
-
-
-
-
0.0000000000000000000000004215
110.0
CMS2_k127_1112240_189
Acetyltransferase (GNAT) domain
-
-
-
0.000000000000000000000001165
110.0
CMS2_k127_1112240_19
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
6.472e-242
751.0
CMS2_k127_1112240_190
Iron-regulated protein
-
-
-
0.000000000000000000000006147
114.0
CMS2_k127_1112240_191
Transglutaminase-like
-
-
-
0.00000000000000000003809
104.0
CMS2_k127_1112240_192
FecR protein
-
-
-
0.000000000000000006526
97.0
CMS2_k127_1112240_193
Acyltransferase family
-
-
-
0.00000000000009774
83.0
CMS2_k127_1112240_194
metal-dependent hydrolase with the TIM-barrel fold
-
-
-
0.0000000000001398
74.0
CMS2_k127_1112240_195
TM2 domain
-
-
-
0.0000000000009601
81.0
CMS2_k127_1112240_196
Acyltransferase family
-
-
-
0.00000000001722
76.0
CMS2_k127_1112240_199
Uncharacterized protein conserved in bacteria (DUF2065)
K09937
-
-
0.00000002468
57.0
CMS2_k127_1112240_2
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
K00982
-
2.7.7.42,2.7.7.89
0.0
1217.0
CMS2_k127_1112240_20
COG0277 FAD FMN-containing dehydrogenases
K00803
-
2.5.1.26
2.349e-239
751.0
CMS2_k127_1112240_200
-
-
-
-
0.0000002343
58.0
CMS2_k127_1112240_201
-
-
-
-
0.0000002352
63.0
CMS2_k127_1112240_202
ankyrin repeat
K15502,K15503,K15504
-
-
0.0000004828
63.0
CMS2_k127_1112240_21
Deoxyguanosinetriphosphate triphosphohydrolase-like protein
K01129
-
3.1.5.1
2.81e-238
741.0
CMS2_k127_1112240_22
Glycerol-3-phosphate dehydrogenase
K00111
-
1.1.5.3
1.489e-234
736.0
CMS2_k127_1112240_23
Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K03272
-
2.7.1.167,2.7.7.70
1.426e-230
722.0
CMS2_k127_1112240_24
Catalyzes the biosynthesis of agmatine from arginine
K01585
-
4.1.1.19
3.611e-224
714.0
CMS2_k127_1112240_25
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
1.363e-223
700.0
CMS2_k127_1112240_26
Ammonium Transporter
K03320
-
-
1.413e-217
681.0
CMS2_k127_1112240_27
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
K02622
-
-
0.0
1099.0
CMS2_k127_1112240_50
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
K03582
-
3.1.11.5
1.615e-205
681.0
CMS2_k127_1260605_40
TRAP-type mannitol chloroaromatic compound transport system, small permease component
A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K09888
-
-
0.0000000000000000000000000001316
117.0
CMS2_k127_1338019_112
Protein of unknown function (DUF2390)
-
-
-
0.00000000000000000000000003401
113.0
CMS2_k127_1338019_113
-
K01865
-
5.4.4.1
0.0000000000000000000000001246
111.0
CMS2_k127_1338019_114
Histidine kinase-like ATPases
-
-
-
0.000000000000000000000000337
117.0
CMS2_k127_1338019_115
-
-
-
-
0.00000000000000000000008092
101.0
CMS2_k127_1338019_116
COG2104 Sulfur transfer protein involved in thiamine biosynthesis
K03154
-
-
0.0000000000000000000001039
98.0
CMS2_k127_1338019_117
BPTI/Kunitz family of serine protease inhibitors.
-
-
-
0.0000000000000000000001643
100.0
CMS2_k127_1338019_119
TIGRFAM TIGR02449 family protein
K09892
-
-
0.0000000000000000004283
88.0
CMS2_k127_1338019_12
ABC transporter ATP-binding protein
K06158
-
-
7.232e-238
753.0
CMS2_k127_1338019_120
-
-
-
-
0.000000000000000005374
89.0
CMS2_k127_1338019_121
domain, Protein
K15125
-
-
0.00000000000000001966
97.0
CMS2_k127_1338019_124
STAS-like domain of unknown function (DUF4325)
-
-
-
0.00000000000004392
76.0
CMS2_k127_1338019_126
Multidrug resistance efflux pump
-
-
-
0.000000001038
60.0
CMS2_k127_1338019_127
-
-
-
-
0.0000006789
51.0
CMS2_k127_1338019_128
-
-
-
-
0.000001824
57.0
CMS2_k127_1338019_129
-
-
-
-
0.000006878
56.0
CMS2_k127_1338019_13
Bacterial Ig-like domain
-
-
-
6.953e-235
762.0
CMS2_k127_1338019_131
to Hemin uptake protein hemP of Yersinia UniRef RepID HEMP_YEREN
-
-
-
0.0000478
49.0
CMS2_k127_1338019_14
Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
K00833
-
2.6.1.62
3.95e-231
722.0
CMS2_k127_1338019_15
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
K01919
-
6.3.2.2
1.769e-229
721.0
CMS2_k127_1338019_16
Ammonium transporter
K03320
-
-
1.121e-226
707.0
CMS2_k127_1338019_17
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
2.346e-224
703.0
CMS2_k127_1338019_18
Belongs to the GppA Ppx family
K01524
-
3.6.1.11,3.6.1.40
1.43e-223
704.0
CMS2_k127_1338019_19
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Belongs to the acetyltransferase family. ArgA subfamily
K14682
-
2.3.1.1
2.429e-195
617.0
CMS2_k127_1338019_25
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
1.08e-252
783.0
CMS2_k127_1338019_90
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1634.0
CMS2_k127_2362804_1
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1455.0
CMS2_k127_2362804_10
Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains
K02667
-
-
5.666e-198
627.0
CMS2_k127_2362804_11
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
7.021e-197
617.0
CMS2_k127_2362804_12
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.0
1378.0
CMS2_k127_2362804_20
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
3.905e-244
764.0
CMS2_k127_2362804_70
Antibiotic biosynthesis monooxygenase
-
GO:0003674,GO:0003824
-
0.0000000000000000000000000000000000000000001455
162.0
CMS2_k127_2362804_71
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K02954
-
-
0.00000000000000000000000000000000000000001584
156.0
CMS2_k127_2362804_72
Belongs to the bacterial ribosomal protein bL27 family
K02899
-
-
0.00000000000000000000000000000000000000006721
151.0
CMS2_k127_2362804_73
Forkhead associated domain
-
-
-
0.0000000000000000000000000000000000000002043
161.0
CMS2_k127_2362804_74
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.000000000000000000000000000000000000008738
146.0
CMS2_k127_2362804_75
-
-
-
-
0.0000000000000000000000000000000000000108
158.0
CMS2_k127_2362804_76
-
-
-
-
0.0000000000000000000000000000000000000426
146.0
CMS2_k127_2362804_77
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.864e-237
740.0
CMS2_k127_2362804_80
Type II transport protein GspH
-
-
-
0.00000000000000000000000000000000008521
139.0
CMS2_k127_2362804_82
Prokaryotic N-terminal methylation motif
K02671
-
-
0.000000000000000000000000000001705
126.0
CMS2_k127_2362804_83
Tfp pilus assembly protein PilE
K02655
-
-
0.0000000000000000000000000001056
119.0
CMS2_k127_2362804_84
Pilus assembly protein PilX
-
-
-
0.0000000000000000000000000001415
122.0
CMS2_k127_2362804_85
Ribosomal protein L30
K02907
-
-
0.000000000000000000000099
99.0
CMS2_k127_2362804_86
Belongs to the universal ribosomal protein uL29 family
K02904
-
-
0.000000000000000000003651
93.0
CMS2_k127_2362804_87
Domain of unknown function (DUF4124)
-
-
-
0.00000000000000000001563
100.0
CMS2_k127_2362804_89
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.00000000000000002882
81.0
CMS2_k127_2362804_9
Histidine kinase
-
-
-
1.523e-227
730.0
CMS2_k127_2362804_90
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.000000000000001178
76.0
CMS2_k127_2362804_91
Cysteine-rich CPXCG
-
-
-
0.000000000000004291
76.0
CMS2_k127_2362804_92
-
-
-
-
0.000000139
53.0
CMS2_k127_2362804_94
transcriptional regulator, TetR family
-
-
-
0.0000007159
60.0
CMS2_k127_2362804_96
Prokaryotic N-terminal methylation motif
K08084,K08085
-
-
0.00008145
53.0
CMS2_k127_2619043_0
DEAD-like helicases superfamily
-
-
-
0.0
1683.0
CMS2_k127_2619043_1
2-oxoglutarate dehydrogenase
K00164
-
1.2.4.2
0.0
1644.0
CMS2_k127_2619043_10
2-oxoglutarate dehydrogenase complex
K00382
-
1.8.1.4
1.263e-253
788.0
CMS2_k127_2619043_11
Acetyl-CoA hydrolase
-
-
-
1.962e-249
790.0
CMS2_k127_2619043_12
BFD-like [2Fe-2S] binding domain
K00362
-
1.7.1.15
2.565e-216
690.0
CMS2_k127_2619043_13
Short chain dehydrogenase
-
-
-
8.963e-207
659.0
CMS2_k127_2619043_14
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
1.061e-206
647.0
CMS2_k127_2619043_15
Domain of unknown function (DUF1837)
-
-
-
1.366e-200
628.0
CMS2_k127_2619043_16
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present
K03657
-
3.6.4.12
0.0
1112.0
CMS2_k127_2619043_30
SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
K09913
-
2.4.2.1,2.4.2.2
0.0000000000000000000000000000000000000008278
150.0
CMS2_k127_2619043_64
phosphohistidine phosphatase
K08296
-
-
0.00000000000000000000000000000000000002884
149.0
CMS2_k127_2619043_65
protein conserved in bacteria
K09977
-
-
0.00000000000000000000000000000000000004693
153.0
CMS2_k127_2619043_66
YCII-related domain
-
-
-
0.0000000000000000000000000000000001857
136.0
CMS2_k127_2619043_67
Metallopeptidase family M24
-
-
-
0.00000000000000000000000007208
118.0
CMS2_k127_2619043_68
thiolester hydrolase activity
-
-
-
0.000000000000000000000000271
111.0
CMS2_k127_2619043_69
Protein of unknown function (DUF1524)
-
-
-
0.0000000000000000000000002754
113.0
CMS2_k127_2619043_7
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.063e-263
818.0
CMS2_k127_2619043_70
-
-
-
-
0.000000000000000000000122
100.0
CMS2_k127_2619043_71
-
-
-
-
0.0000000000000000000002459
104.0
CMS2_k127_2619043_73
Pentapeptide repeats (8 copies)
-
-
-
0.000000000000000703
88.0
CMS2_k127_2619043_74
COG2801 Transposase and inactivated derivatives
K07497
-
-
0.00000000005582
63.0
CMS2_k127_2619043_76
-
-
-
-
0.0000000007464
67.0
CMS2_k127_2619043_78
-
-
-
-
0.000000009122
60.0
CMS2_k127_2619043_79
-
-
-
-
0.000004217
51.0
CMS2_k127_2619043_8
COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components
K15576
-
-
1.229e-256
795.0
CMS2_k127_2619043_81
Protein of unknown function (DUF3592)
-
-
-
0.0001013
51.0
CMS2_k127_2619043_82
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
-
-
-
0.0001621
46.0
CMS2_k127_2619043_9
Belongs to the citrate synthase family
K01647
-
2.3.3.1
2.572e-254
788.0
CMS2_k127_3053778_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1351.0
CMS2_k127_3053778_1
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1253.0
CMS2_k127_3053778_10
unusual protein kinase
-
-
-
2.036e-215
677.0
CMS2_k127_3053778_100
YcgL domain-containing protein
K09902
-
-
0.0000000000000000000004486
99.0
CMS2_k127_3053778_101
-
-
-
-
0.0000000000000000000025
100.0
CMS2_k127_3053778_102
Bacterioferritin-associated ferredoxin
K02192
-
-
0.000000000000000000007624
93.0
CMS2_k127_3053778_103
RDD family
-
-
-
0.0000000000000000001014
89.0
CMS2_k127_3053778_104
MFS transporter
-
-
-
0.000000000000000008313
88.0
CMS2_k127_3053778_105
(Hpt) domain
K20976
-
-
0.00000000000000001258
86.0
CMS2_k127_3053778_106
Competence protein ComEA
K02237
-
-
0.000000000000003558
78.0
CMS2_k127_3053778_107
-
-
-
-
0.0000000000002715
74.0
CMS2_k127_3053778_11
Belongs to the aspartokinase family
K00928
-
2.7.2.4
1.22e-211
662.0
CMS2_k127_3053778_111
Pilus assembly protein PilZ
-
-
-
0.000001749
55.0
CMS2_k127_3053778_114
Recombinase zinc beta ribbon domain
-
-
-
0.00001369
49.0
CMS2_k127_3053778_115
COG2801 Transposase and inactivated derivatives
K07497
-
-
0.00005418
46.0
CMS2_k127_3053778_116
Two component signalling adaptor domain
K03408
-
-
0.000169
54.0
CMS2_k127_3053778_117
Transcriptional regulators
-
-
-
0.0005692
43.0
CMS2_k127_3053778_12
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
2.778e-205
654.0
CMS2_k127_3053778_13
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine
K12960
-
3.5.4.28,3.5.4.31
1.393e-194
618.0
CMS2_k127_3053778_14
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K06131
-
-
1.672e-194
617.0
CMS2_k127_3053778_15
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
2.398e-194
614.0
CMS2_k127_3053778_16
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K09747
-
-
0.00000000000000000000000000000000000000000003042
162.0
CMS2_k127_3053778_9
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
K00322
-
1.6.1.1
7.276e-220
689.0
CMS2_k127_3053778_90
Protein of unknown function (DUF541)
K09807
-
-
0.00000000000000000000000000000000000004802
151.0
CMS2_k127_3053778_91
consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.0000000000000000000000000000000000005106
149.0
CMS2_k127_3053778_92
protein conserved in bacteria
K09938
-
-
0.000000000000000000000000000000000004181
151.0
CMS2_k127_3053778_93
cheY-homologous receiver domain
-
-
-
0.0000000000000000000000000000000001259
137.0
CMS2_k127_3053778_94
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K03563
-
-
0.0000000000000000000000000665
110.0
CMS2_k127_3053778_98
Ion channel
-
-
-
0.000000000000000000000001001
109.0
CMS2_k127_3053778_99
Modulates RecA activity
K03565
-
-
0.0000000000000000000001261
106.0
CMS2_k127_439604_0
Animal haem peroxidase
-
-
-
0.0
1662.0
CMS2_k127_439604_1
COG2909 ATP-dependent transcriptional regulator
-
-
-
0.0
1378.0
CMS2_k127_439604_10
Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)
-
-
-
1.211e-232
729.0
CMS2_k127_439604_11
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
0.0001697
46.0
CMS2_k127_439604_49
-
-
-
-
0.0003497
47.0
CMS2_k127_439604_5
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
1.955e-275
854.0
CMS2_k127_439604_6
multicopper oxidases
-
-
-
9.655e-274
855.0
CMS2_k127_439604_7
TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC
K17686
-
3.6.3.54
1.125e-254
807.0
CMS2_k127_439604_8
protein conserved in bacteria
-
-
-
4.282e-254
785.0
CMS2_k127_439604_9
flavoprotein involved in K transport
-
-
-
2.421e-234
734.0
CMS2_k127_439945_0
Alpha-2-Macroglobulin
K06894
-
-
0.0
1444.0
CMS2_k127_439945_1
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K01681
-
4.2.1.3
0.0
1410.0
CMS2_k127_439945_10
Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA
K00219
-
1.3.1.34
1.436e-317
984.0
CMS2_k127_439945_100
Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
2.336e-256
796.0
CMS2_k127_439945_190
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
-
-
-
0.00000000000000000000000000000000001363
139.0
CMS2_k127_439945_235
MarR family
-
-
-
0.00000000000000000000000000000000001408
139.0
CMS2_k127_439945_236
-
-
-
-
0.00000000000000000000000000000000002559
144.0
CMS2_k127_439945_237
-
-
-
-
0.00000000000000000000000000000000005818
147.0
CMS2_k127_439945_238
-
-
-
-
0.0000000000000000000000000000000003542
134.0
CMS2_k127_439945_239
Helix-turn-helix domain
K07483
-
-
0.00000000000000000000000000000001254
129.0
CMS2_k127_439945_24
-
-
-
-
3.883e-247
778.0
CMS2_k127_439945_240
-
-
-
-
0.00000000000000000000000000000001668
128.0
CMS2_k127_439945_241
Belongs to the bacterial ribosomal protein bS16 family
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
1.172e-245
765.0
CMS2_k127_439945_250
Phosphate-starvation-inducible E
-
-
-
0.0000000000000000000000001272
107.0
CMS2_k127_439945_251
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.000000000000000000000001055
113.0
CMS2_k127_439945_252
Domain of unknown function (DUF4154)
-
-
-
0.000000000000000000000001497
110.0
CMS2_k127_439945_253
Domain of unknown function (DUF3520)
K07114
-
-
0.000000000000000000000005909
117.0
CMS2_k127_439945_254
Transposase
K07497
-
-
0.00000000000000000000001303
102.0
CMS2_k127_439945_255
-
-
-
-
0.00000000000000000000001336
109.0
CMS2_k127_439945_256
Late embryogenesis abundant protein
-
-
-
0.0000000000000000000001271
104.0
CMS2_k127_439945_257
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
K00121
-
1.1.1.1,1.1.1.284
3.384e-224
700.0
CMS2_k127_439945_35
Pkd domain containing protein
-
-
-
2.157e-222
703.0
CMS2_k127_439945_36
COG1960 Acyl-CoA dehydrogenases
K00249
-
1.3.8.7
4.962e-222
693.0
CMS2_k127_439945_37
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
K00632
-
2.3.1.16
4.64e-220
687.0
CMS2_k127_439945_38
COG1960 Acyl-CoA dehydrogenases
-
-
-
1.674e-216
678.0
CMS2_k127_439945_39
flavoprotein involved in K transport
-
-
-
2.513e-216
681.0
CMS2_k127_439945_4
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
K01825
-
1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8
0.0
1192.0
CMS2_k127_439945_40
homoserine dehydrogenase
K00003
-
1.1.1.3
5.145e-216
677.0
CMS2_k127_439945_41
Penicillin-Binding Protein C-terminus Family
K05367
-
2.4.1.129
9.108e-216
697.0
CMS2_k127_439945_42
Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K01733
-
4.2.3.1
3.412e-214
667.0
CMS2_k127_439945_43
MMPL family
K07003
-
-
4.701e-214
691.0
CMS2_k127_439945_44
COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
-
-
-
1.066e-211
664.0
CMS2_k127_439945_45
catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP
K00647
-
2.3.1.41
2.129e-208
654.0
CMS2_k127_439945_46
Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
K00626
-
2.3.1.9
1.983e-205
645.0
CMS2_k127_439945_47
Belongs to the selenophosphate synthase 1 family. Class I subfamily
K01008
-
2.7.9.3
4.576e-205
661.0
CMS2_k127_439945_48
Belongs to the peptidase S1C family
K04691,K04771,K04772
-
3.4.21.107
5.196e-205
646.0
CMS2_k127_439945_49
acyl-CoA transferases carnitine dehydratase
K07749
-
2.8.3.16
2.247e-204
642.0
CMS2_k127_439945_5
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0
1122.0
CMS2_k127_439945_50
Domain of unknown function (DUF3520)
K07114
-
-
5.215e-203
654.0
CMS2_k127_439945_51
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA
K03215
-
2.1.1.190
1.254e-201
636.0
CMS2_k127_439945_52
COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18138
-
-
0.0
1549.0
CMS2_k127_4748133_1
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
2.284e-216
676.0
CMS2_k127_4748133_7
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm
K01869
-
6.1.1.4
0.0
1358.0
CMS2_k127_4748973_1
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K03580
-
-
0.0
1206.0
CMS2_k127_4748973_10
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
3.533e-214
671.0
CMS2_k127_4748973_11
DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
K03732
-
3.6.4.13
7.677e-206
647.0
CMS2_k127_4748973_12
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
3.846e-204
645.0
CMS2_k127_4748973_13
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)
K02275
-
1.9.3.1
6.841e-199
629.0
CMS2_k127_4748973_14
COG0501 Zn-dependent protease with chaperone function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K02274,K02298
-
1.10.3.10,1.9.3.1
0.0
1004.0
CMS2_k127_4748973_20
Transfers the fatty acyl group on membrane lipoproteins
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
8.296e-238
741.0
CMS2_k127_4748973_60
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K03643
-
-
0.0000000000000000000000000007611
119.0
CMS2_k127_4748973_78
sequence-specific DNA binding
-
-
-
0.0000000000000000000000000009097
116.0
CMS2_k127_4748973_8
Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
K02558
-
6.3.2.45
5.055e-219
686.0
CMS2_k127_4748973_80
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide
hydrolases or acyltransferases (alpha beta hydrolase superfamily)
-
-
-
8.123e-217
680.0
CMS2_k127_5505049_0
DNA polymerase
K02337
-
2.7.7.7
0.0
1757.0
CMS2_k127_5505049_1
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1600.0
CMS2_k127_5505049_10
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
6.796e-283
877.0
CMS2_k127_5505049_120
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
1.249e-275
854.0
CMS2_k127_5505049_140
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04078
-
-
0.0000000000000000000000000000000000000000002171
161.0
CMS2_k127_5505049_19
COG0642 Signal transduction histidine kinase
-
-
-
1.374e-259
831.0
CMS2_k127_5505049_190
Membrane protein required for beta-lactamase induction
K03807
-
-
0.0000000000000000000000000000000000000000007153
168.0
CMS2_k127_5505049_191
Belongs to the UPF0307 family
K09889
-
-
0.000000000000000000000000000000000000000009268
159.0
CMS2_k127_5505049_192
Belongs to the N-Me-Phe pilin family
K02650
-
-
0.00000000000000000000000000000000000000001601
158.0
CMS2_k127_5505049_194
YaeQ
-
-
-
0.000000000000000000000000000000000000000261
155.0
CMS2_k127_5505049_195
DNA polymerase III chi subunit
K02339
-
2.7.7.7
0.0000000000000000000000000000000000003522
144.0
CMS2_k127_5505049_196
Protein of unknown function (DUF2834)
-
-
-
0.000000000000000000000000000000000001547
142.0
CMS2_k127_5505049_197
Belongs to the UPF0102 family
K07460
-
-
0.00000000000000000000000000000000001359
140.0
CMS2_k127_5505049_198
Thioredoxin
K03671
-
-
0.00000000000000000000000000000000008341
136.0
CMS2_k127_5505049_199
This enzyme acetylates the N-terminal alanine of ribosomal protein S18
K03789
-
2.3.1.128
0.000000000000000000000000000000006906
133.0
CMS2_k127_5505049_2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1562.0
CMS2_k127_5505049_20
COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
-
-
-
7.337e-258
811.0
CMS2_k127_5505049_200
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K05589
-
-
0.00000000000000000000000000000006375
127.0
CMS2_k127_5505049_201
-
-
-
-
0.0000000000000000000000000000001273
134.0
CMS2_k127_5505049_202
Methyltransferase
K07443
-
-
0.0000000000000000000000000000001483
127.0
CMS2_k127_5505049_203
Heme iron utilization protein
-
-
-
0.0000000000000000000000000000002149
133.0
CMS2_k127_5505049_204
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.000000000000000000000000000001145
123.0
CMS2_k127_5505049_205
Belongs to the BolA IbaG family
-
-
-
0.000000000000000000000000000004248
122.0
CMS2_k127_5505049_206
Phosphocarrier protein HPr
K08485,K11189
-
-
0.0000000000000000000000000001972
117.0
CMS2_k127_5505049_207
4-oxalocrotonate tautomerase
K01821
-
5.3.2.6
0.000000000000000000000000002904
111.0
CMS2_k127_5505049_208
Lipopolysaccharide-assembly, LptC-related
K11719
-
-
0.000000000000000000000000003264
117.0
CMS2_k127_5505049_209
-
-
-
-
0.00000000000000000000000000792
115.0
CMS2_k127_5505049_21
belongs to the aldehyde dehydrogenase family
K22445
-
1.2.99.10
1.967e-254
794.0
CMS2_k127_5505049_210
Protein of unknown function (DUF3301)
-
-
-
0.00000000000000000000000002141
112.0
CMS2_k127_5505049_211
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K09774
-
-
0.00000000000000000000000004724
114.0
CMS2_k127_5505049_212
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09862
-
-
0.00000000000000000002775
93.0
CMS2_k127_5505049_216
Cytochrome c
-
-
-
0.000000000000000005115
89.0
CMS2_k127_5505049_217
-
-
-
-
0.00000000000001914
79.0
CMS2_k127_5505049_218
-
-
-
-
0.000000000008495
73.0
CMS2_k127_5505049_22
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
8.973e-251
780.0
CMS2_k127_5505049_24
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
7.807e-246
764.0
CMS2_k127_5505049_25
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
6.104e-244
761.0
CMS2_k127_5505049_26
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
6.935e-244
757.0
CMS2_k127_5505049_27
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
1.18e-242
754.0
CMS2_k127_5505049_28
Belongs to the MurCDEF family
K01924
-
6.3.2.8
9.901e-239
746.0
CMS2_k127_5505049_29
Belongs to the sulfate adenylyltransferase family
K00958
-
2.7.7.4
3.84e-234
728.0
CMS2_k127_5505049_3
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00163
-
1.2.4.1
0.0
1396.0
CMS2_k127_5505049_30
Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase
K03568
-
-
2.559e-233
729.0
CMS2_k127_5505049_31
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
K18691
-
-
3.027e-233
741.0
CMS2_k127_5505049_32
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
2.102e-232
723.0
CMS2_k127_5505049_33
COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit
K01474
-
3.5.2.14
2.913e-232
729.0
CMS2_k127_5505049_34
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
7.22e-228
711.0
CMS2_k127_5505049_36
serine threonine protein kinase
K12132
-
2.7.11.1
1.413e-226
737.0
CMS2_k127_5505049_37
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
1.938e-222
695.0
CMS2_k127_5505049_38
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
2.717e-210
660.0
CMS2_k127_5505049_39
Protein of unknown function (DUF3592)
-
-
-
1.392e-202
646.0
CMS2_k127_5505049_4
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1377.0
CMS2_k127_5505049_40
Rod shape-determining protein
K03569
-
-
5.19e-202
634.0
CMS2_k127_5505049_41
Acts as a magnesium transporter
K06213
-
-
9.363e-202
637.0
CMS2_k127_5505049_42
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K00627
-
2.3.1.12
3.802e-201
640.0
CMS2_k127_5505049_43
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
1.657e-200
635.0
CMS2_k127_5505049_44
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
3.332e-198
622.0
CMS2_k127_5505049_45
Domain of Unknown Function (DUF748)
-
-
-
4.103e-194
641.0
CMS2_k127_5505049_46
COG4775 Outer membrane protein protective antigen OMA87
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
protein possibly involved in aromatic compounds catabolism
-
-
-
0.00000000000000000000000000000000000000003323
156.0
CMS2_k127_5579411_13
Belongs to the GMC oxidoreductase family
-
-
-
9.097e-285
881.0
CMS2_k127_5579411_130
TIGRFAM RHS repeat-associated core domain
-
-
-
0.00000000000000000000000000000000000000003707
156.0
CMS2_k127_5579411_131
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
K04764
-
-
0.00000000000000000000000000000000000000006008
153.0
CMS2_k127_5579411_132
Domain of unknown function (DUF4124)
-
-
-
0.00000000000000000000000000000000000000006802
156.0
CMS2_k127_5579411_133
Superfamily II DNA RNA helicases, SNF2 family
-
-
-
0.00000000000000000000000000000000000001201
147.0
CMS2_k127_5579411_134
TIGRFAM RHS repeat-associated core domain
-
-
-
0.00000000000000000000000000000000000002818
151.0
CMS2_k127_5579411_135
phosphorelay signal transduction system
-
-
-
0.00000000000000000000000000000000000006047
146.0
CMS2_k127_5579411_136
-
-
-
-
0.0000000000000000000000000000000000009139
142.0
CMS2_k127_5579411_137
Transcriptional
-
-
-
0.00000000000000000000000000000000001046
139.0
CMS2_k127_5579411_138
protein conserved in bacteria
-
-
-
0.00000000000000000000000000000000002077
142.0
CMS2_k127_5579411_139
-
-
-
-
0.0000000000000000000000000000001372
126.0
CMS2_k127_5579411_14
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.00000000000000000000000003248
109.0
CMS2_k127_5579411_147
Iron Permease
K07243
-
-
0.00000000000000000000000006619
112.0
CMS2_k127_5579411_148
protein conserved in bacteria
K09916
-
-
0.0000000000000000000000003371
108.0
CMS2_k127_5579411_149
surface antigen
-
-
-
0.0000000000000000000000005411
115.0
CMS2_k127_5579411_15
Acetyl propionyl-CoA carboxylase, alpha subunit
K13777
-
6.4.1.5
1.07e-277
868.0
CMS2_k127_5579411_150
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes)
K03812
-
-
0.00000000000000000000001444
101.0
CMS2_k127_5579411_151
transcriptional regulator
K07733
-
-
0.00000000000000000000003309
100.0
CMS2_k127_5579411_153
Belongs to the 'phage' integrase family
-
-
-
0.00000000000000000002134
91.0
CMS2_k127_5579411_154
-
-
-
-
0.00000000000000000002921
94.0
CMS2_k127_5579411_157
COG0526 Thiol-disulfide isomerase and thioredoxins
-
-
-
0.0000000000000001959
81.0
CMS2_k127_5579411_159
-
-
-
-
0.00000000000001984
83.0
CMS2_k127_5579411_16
Protein of unknown function (DUF1302)
-
-
-
9.088e-276
862.0
CMS2_k127_5579411_160
Transposase
-
-
-
0.000000000000129
75.0
CMS2_k127_5579411_164
Bacterial regulatory proteins, tetR family
K09017
-
-
0.0000000003866
68.0
CMS2_k127_5579411_165
-
-
-
-
0.00000004397
59.0
CMS2_k127_5579411_17
Acetyl-CoA carboxylase
K13778
-
6.4.1.5
5.808e-271
844.0
CMS2_k127_5579411_170
Domain of unknown function (DUF4391)
-
-
-
0.0000005461
53.0
CMS2_k127_5579411_173
-
-
-
-
0.0003504
43.0
CMS2_k127_5579411_174
Domain of unknown function (DUF4391)
-
-
-
0.0004566
43.0
CMS2_k127_5579411_18
cytochrome P450
-
-
-
3.449e-255
792.0
CMS2_k127_5579411_19
Protein of unknown function (DUF1329)
-
-
-
6.468e-245
762.0
CMS2_k127_5579411_2
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0
1457.0
CMS2_k127_5579411_20
COG2067 Long-chain fatty acid transport protein
-
-
-
8.041e-245
760.0
CMS2_k127_5579411_21
acyl-CoA dehydrogenase
K11731
-
-
6.021e-231
717.0
CMS2_k127_5579411_22
Belongs to the 'phage' integrase family
-
-
-
1.035e-227
711.0
CMS2_k127_5579411_23
in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
1.269e-279
877.0
CMS2_k127_5588374_230
COG0491 Zn-dependent hydrolases, including glyoxylases
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes
K07712
-
-
7.586e-257
797.0
CMS2_k127_5588374_300
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530
-
-
0.0000000000000000000000000000000000000000006925
158.0
CMS2_k127_5588374_343
Phosphoribosyl-ATP
K01523
-
3.6.1.31
0.000000000000000000000000000000000000000001011
159.0
CMS2_k127_5588374_344
COG2801 Transposase and inactivated derivatives
K07497
-
-
0.000000000000000000000000000000000000000001242
157.0
CMS2_k127_5588374_345
YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the
K09780
-
-
0.00000000000000000000000000000000000000001277
154.0
CMS2_k127_5588374_346
COG1943 Transposase and inactivated derivatives
-
-
-
0.000000000000000000000000000000000000000151
156.0
CMS2_k127_5588374_347
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
-
-
-
0.0000000000000000000000000000000000000003692
150.0
CMS2_k127_5588374_348
-
-
-
-
0.0000000000000000000000000000000000000138
150.0
CMS2_k127_5588374_349
COG3288 NAD NADP transhydrogenase alpha subunit
K00324
-
1.6.1.2
0.00000000000000000000000000000000000003361
147.0
CMS2_k127_5588374_35
Sulfate permease and related transporters (MFS superfamily)
COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
-
-
-
0.000000000000000000000000000001035
126.0
CMS2_k127_5588374_37
Belongs to the glutamate synthase family
-
-
-
2.318e-243
763.0
CMS2_k127_5588374_370
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K03676
-
-
0.00000000000000000000000000002542
119.0
CMS2_k127_5588374_371
PFAM Transglycosylase-associated protein
-
-
-
0.00000000000000000000000000002665
119.0
CMS2_k127_5588374_372
radical SAM domain protein
K22226
-
-
0.0000000000000000000000000000797
122.0
CMS2_k127_5588374_373
COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
K05710
-
-
0.00000000000000000000000000008287
119.0
CMS2_k127_5588374_374
Belongs to the sulfur carrier protein TusA family
-
-
-
0.0000000000000000000000000002264
117.0
CMS2_k127_5588374_375
GDYXXLXY protein
-
-
-
0.0000000000000000000000000005451
122.0
CMS2_k127_5588374_376
protein conserved in bacteria
-
-
-
0.00000000000000000000000000106
117.0
CMS2_k127_5588374_377
Sporulation related domain
K03749
-
-
0.000000000000000000000000001062
120.0
CMS2_k127_5588374_379
-
-
-
-
0.0000000000000000000000006754
109.0
CMS2_k127_5588374_38
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
1.281e-242
753.0
CMS2_k127_5588374_380
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.000000000000000000000001039
108.0
CMS2_k127_5588374_381
Prokaryotic N-terminal methylation motif
K02457
-
-
0.00000000000000000000008058
106.0
CMS2_k127_5588374_382
Protein of unknown function (DUF1232)
-
-
-
0.0000000000000000000002366
102.0
CMS2_k127_5588374_383
relative of glutathione S-transferase, MAPEG superfamily
K07136
-
-
0.000000000000000000004698
97.0
CMS2_k127_5588374_384
Sulfotransferase family
-
-
-
0.000000000000000000196
99.0
CMS2_k127_5588374_386
-
-
-
-
0.000000000000000001748
92.0
CMS2_k127_5588374_387
penicillin-binding protein
-
-
-
0.0000000000000000126
91.0
CMS2_k127_5588374_388
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.00000000000000003831
84.0
CMS2_k127_5588374_389
Protein of unknown function (DUF2970)
-
-
-
0.000000000000002158
85.0
CMS2_k127_5588374_39
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
1.326e-241
755.0
CMS2_k127_5588374_390
Putative prokaryotic signal transducing protein
-
-
-
0.00000000000001166
78.0
CMS2_k127_5588374_391
polysaccharide catabolic process
K01179,K01218
-
3.2.1.4,3.2.1.78
0.00000000000005275
86.0
CMS2_k127_5588374_392
COG2801 Transposase and inactivated derivatives
K07497
-
-
0.00000000000009566
70.0
CMS2_k127_5588374_395
Bacterial regulatory proteins, tetR family
K09017
-
-
0.000000000008137
74.0
CMS2_k127_5588374_396
-
-
-
-
0.00000000008652
64.0
CMS2_k127_5588374_397
Trypsin-like serine protease
K01337
-
3.4.21.50
0.000000000484
73.0
CMS2_k127_5588374_398
Bacterial protein of unknown function (DUF883)
-
-
-
0.0000000005453
64.0
CMS2_k127_5588374_399
-
K07733
-
-
0.000000003175
61.0
CMS2_k127_5588374_4
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K20455
-
4.2.1.117
0.0
1555.0
CMS2_k127_5588374_40
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454
-
-
1.237e-239
750.0
CMS2_k127_5588374_401
-
-
-
-
0.000000009335
58.0
CMS2_k127_5588374_404
-
-
-
-
0.0000001065
54.0
CMS2_k127_5588374_407
Bacterial protein of unknown function (DUF839)
K07093
-
-
0.000004003
50.0
CMS2_k127_5588374_409
-
-
-
-
0.0005464
46.0
CMS2_k127_5588374_41
Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K03314
-
-
6.688e-236
742.0
CMS2_k127_5588374_410
PFAM glycosyl transferase family 2
K00721
-
2.4.1.83
0.0009444
49.0
CMS2_k127_5588374_42
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
1.932e-234
728.0
CMS2_k127_5588374_43
unusual protein kinase
-
-
-
2.349e-233
728.0
CMS2_k127_5588374_44
Malate dehydrogenase
K00027,K00029
-
1.1.1.38,1.1.1.40
8.548e-232
722.0
CMS2_k127_5588374_45
The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
K01696
-
4.2.1.20
6.562e-230
715.0
CMS2_k127_5588374_46
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K03688
-
-
1.409e-227
717.0
CMS2_k127_5588374_47
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
3.811e-227
709.0
CMS2_k127_5588374_48
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K00325
-
1.6.1.2
2.633e-226
707.0
CMS2_k127_5588374_49
ABC-type oligopeptide transport system, periplasmic component
K13893
-
-
2.184e-223
711.0
CMS2_k127_5588374_5
Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues
K01791,K08068
-
3.2.1.183,5.1.3.14
1.766e-209
654.0
CMS2_k127_5588374_6
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
7 transmembrane helices usually fused to an inactive transglutaminase
-
-
-
5.539e-208
657.0
CMS2_k127_5588374_62
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
1.047e-206
646.0
CMS2_k127_5588374_63
P-aminobenzoate N-oxygenase AurF
-
-
-
1.047e-206
646.0
CMS2_k127_5588374_64
Belongs to the DegT DnrJ EryC1 family
-
-
-
2.19e-206
647.0
CMS2_k127_5588374_65
Heparinase II
-
-
-
6.45e-205
654.0
CMS2_k127_5588374_66
Belongs to the GPI family
K01810
-
5.3.1.9
3.576e-204
650.0
CMS2_k127_5588374_67
Acyl-CoA dehydrogenase, C-terminal domain
K00253
-
1.3.8.4
8.661e-204
639.0
CMS2_k127_5588374_68
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01736
-
4.2.3.5
5.38e-203
635.0
CMS2_k127_5588374_69
DNA methylase
K07316
-
2.1.1.72
8.375e-199
632.0
CMS2_k127_5588374_7
Type III restriction enzyme, res subunit
-
-
-
0.0
1405.0
CMS2_k127_5588374_70
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
1.025e-198
623.0
CMS2_k127_5588374_71
Belongs to the ABC transporter superfamily
K13896
-
-
3.86e-198
630.0
CMS2_k127_5588374_72
acyl-CoA dehydrogenase
-
-
-
5.937e-198
633.0
CMS2_k127_5588374_73
Histidine kinase
-
-
-
1.856e-197
631.0
CMS2_k127_5588374_74
Flavin-binding monooxygenase-like
K03379
-
1.14.13.22
2.831e-197
628.0
CMS2_k127_5588374_75
ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component
K02004
-
-
2.113e-196
642.0
CMS2_k127_5588374_76
Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide
K10764
-
-
1.309e-195
617.0
CMS2_k127_5588374_77
Diguanylate cyclase
-
-
-
1.467e-195
657.0
CMS2_k127_5588374_78
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
4.192e-195
612.0
CMS2_k127_5588374_79
Polysaccharide biosynthesis protein C-terminal
K17716
-
5.1.3.2
4.593e-195
612.0
CMS2_k127_5588374_8
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase
K14162
-
2.7.7.7
0.0
1328.0
CMS2_k127_5588374_80
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
1.182e-194
610.0
CMS2_k127_5588374_81
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1205.0
CMS2_k127_5615948_20
Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01895
-
6.2.1.1
0.0
1099.0
CMS2_k127_5615948_30
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.0
1044.0
CMS2_k127_5615948_40
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Participates in both transcription termination and antitermination
K02600
-
-
7.688e-263
816.0
CMS2_k127_5615948_7
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
K05365
-
2.4.1.129,3.4.16.4
5.245e-232
742.0
CMS2_k127_5615948_8
Glutamate-1-semialdehyde aminotransferase
K01845
-
5.4.3.8
1.168e-216
679.0
CMS2_k127_5615948_9
hydroxymethylglutaryl-CoA reductase
K00021
-
1.1.1.34
1.345e-202
637.0
CMS2_k127_5866044_0
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K07787
-
-
0.0
1621.0
CMS2_k127_5866044_1
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1067.0
CMS2_k127_5866044_10
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.00000000000000001044
85.0
CMS2_k127_5866044_104
Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a
-
-
-
0.0000000000000000383
85.0
CMS2_k127_5866044_105
Arc-like DNA binding domain
-
-
-
0.0000000000001346
75.0
CMS2_k127_5866044_107
Domain of unknown function (DUF4124)
-
-
-
0.000006712
57.0
CMS2_k127_5866044_11
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
1.179e-234
745.0
CMS2_k127_5866044_12
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
1.147e-233
739.0
CMS2_k127_5866044_13
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
1.42e-232
725.0
CMS2_k127_5866044_14
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00836
-
2.6.1.76
1.034e-227
711.0
CMS2_k127_5866044_15
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
4.56e-227
709.0
CMS2_k127_5866044_16
-
-
-
-
9.649e-223
701.0
CMS2_k127_5866044_17
flavoprotein involved in K transport
-
-
-
4.33e-221
697.0
CMS2_k127_5866044_18
Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
COG0823 Periplasmic component of the Tol biopolymer transport system
-
-
-
5.592e-278
880.0
CMS2_k127_5866044_70
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Could be involved in insertion of integral membrane proteins into the membrane
K08998
-
-
0.00000000000000000000000001119
114.0
CMS2_k127_5866044_98
4-oxalocrotonate tautomerase
K01821
-
5.3.2.6
0.00000000000000000000000001488
109.0
CMS2_k127_6114024_0
Allophanate hydrolase subunit 1
K01941
-
6.3.4.6
0.0
1893.0
CMS2_k127_6114024_1
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K00362
-
1.7.1.15
0.0
1358.0
CMS2_k127_6114024_10
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00347
-
1.6.5.8
1.794e-229
715.0
CMS2_k127_6114024_11
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
K11085
-
-
2.473e-224
711.0
CMS2_k127_6114024_12
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K00346
-
1.6.5.8
1.997e-208
656.0
CMS2_k127_6114024_13
Thrombospondin type 3 repeat
-
-
-
1.333e-206
667.0
CMS2_k127_6114024_14
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
8.207e-203
637.0
CMS2_k127_6114024_15
Lipoprotein releasing system, transmembrane protein
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
K08300
-
3.1.26.12
1.73e-298
947.0
CMS2_k127_6114024_40
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.00000000000000000000000000000000007266
136.0
CMS2_k127_6114024_9
Nitrate nitrite transporter
K02575
-
-
8.119e-231
724.0
CMS2_k127_6114024_90
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
-
-
-
0.00000000000000000000000000000000573
134.0
CMS2_k127_6114024_92
-
-
-
-
0.000000000000000000000000002572
123.0
CMS2_k127_6114024_93
membrane
-
-
-
0.00000000000000000000000002955
112.0
CMS2_k127_6114024_94
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.00000000000000000000000003219
108.0
CMS2_k127_6114024_95
protein conserved in bacteria
K05952
-
-
0.00000000000000000001018
96.0
CMS2_k127_6114024_96
membrane
-
-
-
0.0000000000000000002326
90.0
CMS2_k127_6114024_97
-
-
-
-
0.000000000000000703
83.0
CMS2_k127_6114024_98
VIT family
-
-
-
0.0000001002
54.0
CMS2_k127_6114024_99
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
K00627,K09699
-
2.3.1.12,2.3.1.168
0.000000261
53.0
CMS2_k127_6741054_0
COG3210 Large exoproteins involved in heme utilization or adhesion
K15125
-
-
0.0
1493.0
CMS2_k127_6741054_1
efflux pump
K18138
-
-
0.0
1371.0
CMS2_k127_6741054_10
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
4.559e-294
906.0
CMS2_k127_6741054_100
Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle
This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.000000000000000000000000000000000000004639
146.0
CMS2_k127_6741054_128
Multidrug transporter
-
-
-
0.00000000000000000000000000000000000004853
146.0
CMS2_k127_6741054_129
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.00000000000000000000000000000000000007831
143.0
CMS2_k127_6741054_13
COG2831 Hemolysin activation secretion protein
-
-
-
1.249e-277
863.0
CMS2_k127_6741054_130
-
-
-
-
0.0000000000000000000000000000000000001716
155.0
CMS2_k127_6741054_131
HNH endonuclease
K07451
-
-
0.0000000000000000000000000000000000005836
147.0
CMS2_k127_6741054_132
Pfam Transposase IS66
-
-
-
0.00000000000000000000000000000000005683
143.0
CMS2_k127_6741054_133
Protein of unknown function (DUF2834)
-
-
-
0.0000000000000000000000000000000001559
134.0
CMS2_k127_6741054_135
type III effector
-
-
-
0.0000000000000000000000000000000005344
136.0
CMS2_k127_6741054_136
Plasmid maintenance system killer
K07334
-
-
0.0000000000000000000000000000000005644
132.0
CMS2_k127_6741054_137
-
-
-
-
0.000000000000000000000000000000000954
141.0
CMS2_k127_6741054_138
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K02110
-
-
0.000000000000000000000000000000001427
130.0
CMS2_k127_6741054_139
cold-shock protein
K03704
-
-
0.000000000000000000000000000000003948
128.0
CMS2_k127_6741054_14
COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II
K00666
-
-
3.871e-276
857.0
CMS2_k127_6741054_140
Gaf domain
K01768,K17763
-
4.6.1.1
0.000000000000000000000000000000008589
132.0
CMS2_k127_6741054_141
-
-
-
-
0.000000000000000000000000009989
113.0
CMS2_k127_6741054_142
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
K03536
-
3.1.26.5
0.00000000000000000000000002937
111.0
CMS2_k127_6741054_143
-
-
-
-
0.0000000000000000000000001322
117.0
CMS2_k127_6741054_144
plasmid maintenance system antidote protein
K21498
-
-
0.0000000000000000000000004086
107.0
CMS2_k127_6741054_145
PgaD-like protein
K11937
-
-
0.00000000000000000000004761
107.0
CMS2_k127_6741054_146
Belongs to the bacterial ribosomal protein bL33 family
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.000000000000001264
78.0
CMS2_k127_6741054_151
-
-
-
-
0.00000000000001597
79.0
CMS2_k127_6741054_152
-
-
-
-
0.0000000000004398
76.0
CMS2_k127_6741054_153
-
-
-
-
0.00000000005491
68.0
CMS2_k127_6741054_155
neuron death in response to oxidative stress
K01173,K07004
-
-
0.00000002264
59.0
CMS2_k127_6741054_157
transcriptional regulator
-
-
-
0.00000008962
62.0
CMS2_k127_6741054_159
Putative diguanylate phosphodiesterase
-
-
-
0.00001126
49.0
CMS2_k127_6741054_16
Secretory lipase
-
-
-
9.649e-258
807.0
CMS2_k127_6741054_160
-
-
-
-
0.00002833
54.0
CMS2_k127_6741054_161
Domain of unknown function (DUF4034)
-
-
-
0.00006907
54.0
CMS2_k127_6741054_17
found to be peripherally associated with the inner membrane in Escherichia coli
K03499
-
-
3.557e-254
788.0
CMS2_k127_6741054_18
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1333.0
CMS2_k127_6741054_20
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
1.009e-240
758.0
CMS2_k127_6741054_21
Protein of unknown function (DUF1298)
K00635
-
2.3.1.20
3.692e-238
742.0
CMS2_k127_6741054_22
NB-ARC domain
K16247
-
-
2.732e-236
760.0
CMS2_k127_6741054_23
N-methylhydantoinase A acetone carboxylase, beta subunit
K01469,K01473
-
3.5.2.14,3.5.2.9
2.409e-231
735.0
CMS2_k127_6741054_24
fatty acid desaturase
K00508
-
1.14.19.3
7.32e-231
718.0
CMS2_k127_6741054_25
gamma-glutamyltransferase
K00681
-
2.3.2.2,3.4.19.13
3.137e-227
717.0
CMS2_k127_6741054_26
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K13038
-
4.1.1.36,6.3.2.5
1.756e-222
694.0
CMS2_k127_6741054_27
belongs to the aldehyde dehydrogenase family
K00154
-
1.2.1.68
2.795e-215
679.0
CMS2_k127_6741054_28
can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
K11105
-
-
1.202e-210
668.0
CMS2_k127_6741054_29
COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
-
-
-
2.705e-210
658.0
CMS2_k127_6741054_3
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
4.302e-208
655.0
CMS2_k127_6741054_32
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
K00820
-
2.6.1.16
1.21e-300
930.0
CMS2_k127_6741054_90
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
Required for chromosome condensation and partitioning
K03529
-
-
0.0
1586.0
CMS2_k127_6750456_10
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
1.047e-285
885.0
CMS2_k127_6750456_100
Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K06199
-
-
0.00000000000000000000000000000000000001576
147.0
CMS2_k127_6750456_129
-
-
-
-
0.00000000000000000000000000000000000004754
147.0
CMS2_k127_6750456_13
acyl-CoA dehydrogenase
K09456
-
-
8.3e-268
833.0
CMS2_k127_6750456_130
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.000000000000000000000000000000000001938
138.0
CMS2_k127_6750456_131
Acyl-CoA-binding protein
-
-
-
0.0000000000000000000000000000000001985
133.0
CMS2_k127_6750456_132
Belongs to the BolA IbaG family
K05527
-
-
0.000000000000000000000000000000001192
133.0
CMS2_k127_6750456_134
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K00077
-
1.1.1.169
0.000000000000000000000000000000007735
140.0
CMS2_k127_6750456_135
ABC-type phosphate transport system, periplasmic component
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COG2303 Choline dehydrogenase and related flavoproteins
K03333
-
1.1.3.6
1.604e-247
773.0
CMS2_k127_6750456_160
TIGRFAM conserved repeat domain
-
-
-
0.00001335
55.0
CMS2_k127_6750456_163
-
-
-
-
0.00007327
51.0
CMS2_k127_6750456_17
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
-
-
5.744e-246
773.0
CMS2_k127_6750456_18
oxidoreductase
-
-
-
3.2e-240
754.0
CMS2_k127_6750456_19
Histidine kinase
K20973
-
2.7.13.3
2.151e-237
755.0
CMS2_k127_6750456_2
Belongs to the ClpA ClpB family
K03694
-
-
0.0
1192.0
CMS2_k127_6750456_20
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
1.214e-226
710.0
CMS2_k127_6750456_21
ATP-dependent helicase HrpB
K03579
-
3.6.4.13
1.657e-225
724.0
CMS2_k127_6750456_22
COG2303 Choline dehydrogenase and related flavoproteins
-
-
-
1.859e-224
707.0
CMS2_k127_6750456_23
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
5.141e-211
662.0
CMS2_k127_6750456_24
-
-
-
-
1.063e-207
661.0
CMS2_k127_6750456_25
ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
3.987e-206
650.0
CMS2_k127_6750456_26
Involved in the TonB-independent uptake of proteins
K03641
-
-
1.035e-203
640.0
CMS2_k127_6750456_27
acyl-CoA dehydrogenase
K00249
-
1.3.8.7
3.213e-199
627.0
CMS2_k127_6750456_28
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01638
-
2.3.3.9
0.0
1124.0
CMS2_k127_6750456_30
Catalyzes the reversible oxidation of malate to oxaloacetate
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
Toxin-antitoxin system, toxin component, Fic family
-
-
-
0.0000000000000000000000000000000000000009081
152.0
CMS2_k127_7064526_55
-
-
-
-
0.00000000000000000000000000000000000003513
152.0
CMS2_k127_7064526_56
Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
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-
-
0.000000000000000000000000000000000009102
139.0
CMS2_k127_7064526_57
Bacterial regulatory proteins, tetR family
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-
-
0.000000000000000000000000000001031
129.0
CMS2_k127_7064526_58
Belongs to the UPF0125 (RnfH) family
K09801
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-
0.000000000000000000000000000001635
123.0
CMS2_k127_7064526_59
Type III secretion system lipoprotein chaperone (YscW)
K09914
-
-
0.0000000000000000000000000003143
125.0
CMS2_k127_7064526_6
Amidohydrolase family
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-
-
2.161e-251
787.0
CMS2_k127_7064526_60
Virulence protein RhuM family
-
-
-
0.000000000000000000001982
95.0
CMS2_k127_7064526_61
Protein of unknown function (DUF4011)
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-
-
0.00000000000000004842
81.0
CMS2_k127_7064526_62
Transcriptional regulator
K07733
-
-
0.0000000000000004199
79.0
CMS2_k127_7064526_7
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
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2.3.3.13
3.132e-247
775.0
CMS2_k127_7064526_8
May be involved in recombinational repair of damaged DNA
