Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K03474
-
2.6.99.2
0.0000000000000000000000000000000000004852
140.0
CMS2_k127_1108969_0
chemotaxis protein
K03406
-
-
2.043e-291
907.0
CMS2_k127_1108969_1
Stage II sporulation protein E (SpoIIE)
-
-
-
2.925e-218
690.0
CMS2_k127_1108969_10
-
-
-
-
0.0000000000000000000000000000004147
124.0
CMS2_k127_1108969_11
Domain present in PSD-95, Dlg, and ZO-1/2.
K02452
-
-
0.00000000000000000000000000004949
126.0
CMS2_k127_1108969_12
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.0000000000000000000000000007894
114.0
CMS2_k127_1108969_13
-
-
-
-
0.00000000000000000002094
97.0
CMS2_k127_1108969_14
Prokaryotic N-terminal methylation motif
-
-
-
0.0003573
49.0
CMS2_k127_1108969_2
COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
1.672e-206
648.0
CMS2_k127_1108969_3
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0
1312.0
CMS2_k127_1214557_20
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
PFAM Adenylate and Guanylate cyclase catalytic domain
K01768
-
4.6.1.1
0.0
1097.0
CMS2_k127_1214557_30
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Belongs to the bacterial ribosomal protein bL33 family
K02913
-
-
0.00000000000000000000000001746
108.0
CMS2_k127_1214557_5
TonB-dependent copper receptor
K02014
-
-
1.929e-299
931.0
CMS2_k127_1214557_50
Prokaryotic N-terminal methylation motif
-
-
-
0.00000000000000000000000897
105.0
CMS2_k127_1214557_51
-
-
-
-
0.00000000000000000000002654
100.0
CMS2_k127_1214557_52
-
K06950
-
-
0.0000000000000000001845
90.0
CMS2_k127_1214557_53
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.000000000000000004907
84.0
CMS2_k127_1214557_54
protein transport across the cell outer membrane
K02455,K12510
-
-
0.00000000000000005834
83.0
CMS2_k127_1214557_57
-
-
-
-
0.000009026
49.0
CMS2_k127_1214557_58
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.00006681
45.0
CMS2_k127_1214557_6
Glycolate oxidase subunit
K00104
-
1.1.3.15
5.442e-289
889.0
CMS2_k127_1214557_7
Cell division protein FtsI penicillin-binding protein
K03587
-
3.4.16.4
6.863e-289
895.0
CMS2_k127_1214557_8
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
4.399e-279
869.0
CMS2_k127_1214557_9
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1188.0
CMS2_k127_1291093_10
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
1.003e-234
730.0
CMS2_k127_1291093_11
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
8.666e-233
722.0
CMS2_k127_1291093_12
Synthesizes alpha-1,4-glucan chains using ADP-glucose
K00703
-
2.4.1.21
1.163e-231
725.0
CMS2_k127_1291093_13
May be involved in recombinational repair of damaged DNA
K03631
-
-
4.668e-224
704.0
CMS2_k127_1291093_14
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
K01679
-
4.2.1.2
5.733e-272
840.0
CMS2_k127_1291093_9
Oxidoreductase
K00174
-
1.2.7.11,1.2.7.3
5.225e-240
742.0
CMS2_k127_1366981_0
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1458.0
CMS2_k127_1366981_1
Domain of unknown function (DUF3458_C) ARM repeats
K01256
-
3.4.11.2
0.0
1357.0
CMS2_k127_1366981_10
von Willebrand factor, type A
K07114
-
-
1.104e-223
711.0
CMS2_k127_1366981_11
COG0402 Cytosine deaminase and related metal-dependent
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
K01465
-
3.5.2.3
7.529e-198
618.0
CMS2_k127_1366981_19
von Willebrand factor, type A
K07114
-
-
1.427e-195
619.0
CMS2_k127_1366981_2
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1305.0
CMS2_k127_1366981_20
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K07277
-
-
0.0
1149.0
CMS2_k127_1366981_40
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
1.758e-306
944.0
CMS2_k127_1366981_50
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04078
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
0.000000000000000000000000000000000000004763
146.0
CMS2_k127_1366981_77
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.0000000000000000000000000000000000001046
150.0
CMS2_k127_1366981_8
Ammonium Transporter
K03320
-
-
2.539e-239
743.0
CMS2_k127_1366981_80
Diguanylate cyclase phosphodiesterase
-
-
-
0.000000000000000000000000000000000375
136.0
CMS2_k127_1366981_82
-
-
-
-
0.0000000000000000000000000004659
116.0
CMS2_k127_1366981_83
Biotin carboxylase
K01959,K01961
-
6.3.4.14,6.4.1.1,6.4.1.2
0.000000000000000000000000002366
114.0
CMS2_k127_1366981_85
LPP20 lipoprotein
-
-
-
0.0000000000000000000001319
110.0
CMS2_k127_1366981_86
CHASE
-
-
-
0.00000000000000000001901
106.0
CMS2_k127_1366981_88
-
-
-
-
0.0000000000000000008188
86.0
CMS2_k127_1366981_89
Required for maturation of 30S ribosomal subunits
K09748
-
-
0.00000000000000008729
86.0
CMS2_k127_1366981_9
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
1.837e-225
699.0
CMS2_k127_1366981_90
nucleic-acid-binding protein implicated in transcription termination
-
-
-
0.00000000000006227
74.0
CMS2_k127_1366981_91
chloride
-
-
-
0.000000000001162
68.0
CMS2_k127_1366981_92
Oxygen tolerance
-
-
-
0.0000000005075
71.0
CMS2_k127_1366981_94
Domain of unknown function (DUF4393)
-
-
-
0.0000001157
62.0
CMS2_k127_1366981_95
Lysin motif
-
-
-
0.0001065
53.0
CMS2_k127_1366981_96
domain containing protein
K01078,K14410,K19283
-
3.1.3.2,3.1.3.5
0.0002274
44.0
CMS2_k127_1399513_0
DUF218 domain
-
-
-
0.00000000000000000000000000000000000000000002749
168.0
CMS2_k127_1399513_1
aminopeptidase activity
-
-
-
0.0000000000000000000000000000000000000003509
149.0
CMS2_k127_1399513_2
-
-
-
-
0.00000000002229
72.0
CMS2_k127_1399513_3
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
0.0000000000000000000000000000000000002571
151.0
CMS2_k127_1604517_3
Putative integral membrane protein (DUF2391)
-
-
-
0.000000000000000000000000000002082
121.0
CMS2_k127_1921646_0
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
2011.0
CMS2_k127_1921646_1
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
1.281e-306
949.0
CMS2_k127_1921646_20
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component
-
-
-
2.292e-240
748.0
CMS2_k127_1921646_5
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
3.393e-236
734.0
CMS2_k127_1921646_6
Glutathionylspermidine synthase
-
-
-
2.828e-221
689.0
CMS2_k127_1921646_7
Part of the tripartite ATP-independent periplasmic (TRAP) transport system
-
-
-
8.407e-203
634.0
CMS2_k127_1921646_8
rod shape-determining protein mreB
K03569
-
-
5.642e-200
625.0
CMS2_k127_1921646_9
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K15896
-
2.3.1.202
0.00000000000001381
81.0
CMS2_k127_1975883_17
Stf0 sulphotransferase
K21014
-
2.8.2.37
0.0000000002854
70.0
CMS2_k127_1975883_19
general secretion pathway protein
K02246,K02247,K02456,K02457,K02458,K10924
-
-
0.0000214
53.0
CMS2_k127_1975883_2
morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Dinitrogenase iron-molybdenum cofactor biosynthesis protein
K02596
-
-
0.0000000000000000000000000000000000009139
142.0
CMS2_k127_1978377_22
Dinitrogenase iron-molybdenum cofactor
-
-
-
0.00000000000000000000000000001179
122.0
CMS2_k127_1978377_24
-
-
-
-
0.00000000000000000004239
90.0
CMS2_k127_1978377_25
Putative heavy-metal chelation
-
-
-
0.000000000000009321
76.0
CMS2_k127_1978377_3
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
5.618e-211
660.0
CMS2_k127_1978377_4
Cysteine desulfurase
K04487
-
2.8.1.7
5.46e-208
651.0
CMS2_k127_1978377_5
Catalyzes the ferrous insertion into protoporphyrin IX
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
K01007
-
2.7.9.2
0.0
1250.0
CMS2_k127_2184181_10
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
6.451e-246
763.0
CMS2_k127_2184181_11
Pilus assembly protein
-
-
-
7.764e-226
709.0
CMS2_k127_2184181_12
na -driven multidrug efflux
-
-
-
8.514e-217
679.0
CMS2_k127_2184181_13
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
1.957e-212
662.0
CMS2_k127_2184181_14
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
3.977e-211
658.0
CMS2_k127_2184181_15
Type II and III secretion system protein
K02453
-
-
2.27e-210
665.0
CMS2_k127_2184181_16
Major Facilitator
-
-
-
2.695e-209
656.0
CMS2_k127_2184181_17
Type II secretion system
K02455,K12278
-
-
9.542e-200
629.0
CMS2_k127_2184181_18
Involved in the TonB-independent uptake of proteins
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
5.205e-306
944.0
CMS2_k127_2184181_50
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
1.218e-264
816.0
CMS2_k127_2184181_80
-
-
-
-
0.0002776
49.0
CMS2_k127_2184181_9
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COGs COG1120 ABC-type cobalamin Fe3 -siderophores transport systems ATPase components
K02013
-
3.6.3.34
0.00000000000000000000000000003027
118.0
CMS2_k127_2193936_3
RNA-binding protein homologous to eukaryotic snRNP
-
-
-
7.047e-235
732.0
CMS2_k127_2193936_32
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
-
-
-
0.0000000001454
71.0
CMS2_k127_2193936_4
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Methyl-accepting chemotaxis protein (MCP) signaling domain
K03406
-
-
0.00000000000000000000000000000000000000004007
158.0
CMS2_k127_2205559_23
-
-
-
-
0.0000000000000000000000000000000000000003229
153.0
CMS2_k127_2205559_24
-
-
-
-
0.000000000000000000000000000000009565
128.0
CMS2_k127_2205559_3
COG0841 Cation multidrug efflux pump
-
-
-
1.551e-284
882.0
CMS2_k127_2205559_4
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
5.72e-279
863.0
CMS2_k127_2205559_5
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00800
-
2.5.1.19
1.501e-224
700.0
CMS2_k127_2205559_6
GGDEF domain
K03090,K03409
-
-
4.231e-209
670.0
CMS2_k127_2205559_7
outer membrane efflux protein
-
-
-
1.254e-197
624.0
CMS2_k127_2205559_8
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.0
1095.0
CMS2_k127_2273404_1
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Oxidizes proline to glutamate for use as a carbon and nitrogen source
K13821
-
1.2.1.88,1.5.5.2
0.0
2012.0
CMS2_k127_2316672_1
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K07787
-
-
0.0
1683.0
CMS2_k127_2316672_10
abc transporter atp-binding protein
K06147,K06148
-
-
6.619e-290
899.0
CMS2_k127_2316672_11
Abc transporter
K02035
-
-
3.747e-277
859.0
CMS2_k127_2316672_12
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
1.163e-266
822.0
CMS2_k127_2316672_13
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K00169
-
1.2.7.1
7.594e-248
767.0
CMS2_k127_2316672_14
transporter
-
-
-
2.198e-236
736.0
CMS2_k127_2316672_15
Belongs to the CarA family
K01956
-
6.3.5.5
1.877e-216
675.0
CMS2_k127_2316672_16
Aminotransferase
-
-
-
2.906e-209
654.0
CMS2_k127_2316672_17
pyruvate ferredoxin oxidoreductase
K00170
-
1.2.7.1
1.31e-205
641.0
CMS2_k127_2316672_18
Metal dependent phosphohydrolases with conserved 'HD' motif.
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Antitoxin component of a toxin-antitoxin (TA) module
-
-
-
0.000000000000000009096
85.0
CMS2_k127_2316672_65
Belongs to the 5'-nucleotidase family
K01119
-
3.1.3.6,3.1.4.16
0.0000000000000001052
87.0
CMS2_k127_2316672_66
CAAX protease self-immunity
K07052
-
-
0.0000000000001423
78.0
CMS2_k127_2316672_67
-
-
-
-
0.000000009564
56.0
CMS2_k127_2316672_7
Acetyltransferase (GNAT) family
-
-
-
0.0
1021.0
CMS2_k127_2316672_70
-
-
-
-
0.0000131
56.0
CMS2_k127_2316672_8
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
3.265e-314
964.0
CMS2_k127_2316672_9
Putative diguanylate phosphodiesterase
-
-
-
3.723e-293
910.0
CMS2_k127_2685136_0
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1457.0
CMS2_k127_2685136_1
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
K03581
-
3.1.11.5
0.0
1292.0
CMS2_k127_2685136_10
Sh3 type 3 domain protein
-
-
-
6.599e-197
622.0
CMS2_k127_2685136_11
Part of the ABC transporter complex PstSACB involved in phosphate import
K02040
-
-
7.156e-197
616.0
CMS2_k127_2685136_12
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.000000000000000000000000000000000000000002823
162.0
CMS2_k127_2685136_8
peptidase U32 family
K08303
-
-
1.134e-254
788.0
CMS2_k127_2685136_80
TOBE domain
-
-
-
0.0000000000000000000000000000000000000002064
153.0
CMS2_k127_2685136_81
Pkd domain containing protein
-
-
-
0.00000000000000000000000000000000000002458
159.0
CMS2_k127_2685136_82
-
-
-
-
0.000000000000000000000000000000000002797
148.0
CMS2_k127_2685136_83
R COG0790 FOG TPR repeat, SEL1 subfamily
K07126
-
-
0.00000000000000000000000000001972
126.0
CMS2_k127_2685136_84
Biopolymer transport protein ExbD/TolR
K03559
-
-
0.0000000000000000000004776
100.0
CMS2_k127_2685136_85
Tetratricopeptide repeat
-
-
-
0.00000000000000000001632
107.0
CMS2_k127_2685136_86
Cytochrome c
-
-
-
0.0000000000002116
79.0
CMS2_k127_2685136_87
Doubled CXXCH motif (Paired_CXXCH_1)
-
-
-
0.000000000002407
74.0
CMS2_k127_2685136_88
cytochrome
-
-
-
0.000000005758
66.0
CMS2_k127_2685136_89
Domain of unknown function (DUF4136)
-
-
-
0.000002665
55.0
CMS2_k127_2685136_9
GGDEF domain
-
-
-
8.989e-212
674.0
CMS2_k127_2685136_91
M6 family metalloprotease domain protein
-
-
-
0.0001589
49.0
CMS2_k127_324445_0
Glycyl-tRNA synthetase beta subunit
K01879
-
6.1.1.14
0.0
1083.0
CMS2_k127_324445_1
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation
K02591
-
1.18.6.1
7.573e-306
940.0
CMS2_k127_324445_10
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO
K21694
-
-
0.0000000000000000000000000000000006291
132.0
CMS2_k127_324445_39
nitrogen fixation protein FixT
K02593
-
-
0.00000000000000000000009683
98.0
CMS2_k127_324445_4
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455
-
-
3.678e-266
827.0
CMS2_k127_324445_40
NifZ domain
K02597
-
-
0.0000000000000000001231
93.0
CMS2_k127_324445_41
response regulator
-
-
-
0.000000000000000000154
101.0
CMS2_k127_324445_43
Metal-binding
-
-
-
0.0000003196
57.0
CMS2_k127_324445_44
Metallo-beta-lactamase superfamily
K22405
-
1.6.3.4
0.00000886
48.0
CMS2_k127_324445_5
cofactor biosynthesis protein NifE
K02587
-
-
6.776e-256
793.0
CMS2_k127_324445_6
Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains
K02584
-
-
2.273e-255
796.0
CMS2_k127_324445_7
fumarate reductase, flavoprotein subunit
K00239,K00244
-
1.3.5.1,1.3.5.4
4.101e-226
712.0
CMS2_k127_324445_8
Diguanylate cyclase
-
-
-
4.548e-213
673.0
CMS2_k127_324445_9
Belongs to the NifD NifK NifE NifN family
K02592
-
-
1.522e-206
649.0
CMS2_k127_3271658_0
ABC transporter, ATP-binding protein
K15738
-
-
0.0
1142.0
CMS2_k127_3271658_1
Belongs to the class-II aminoacyl-tRNA synthetase family
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Probably plays a role in a hydrogenase nickel cofactor insertion step
K04651
-
-
0.00000000000000000000000000000000000000000001088
164.0
CMS2_k127_3271658_21
cheY-homologous receiver domain
K03413
-
-
0.0000000000000000000000000000000000000001656
153.0
CMS2_k127_3271658_22
-
-
-
-
0.00000000000000000000000000000000000001595
157.0
CMS2_k127_3271658_23
DNA-binding protein VF530
-
-
-
0.00000000000000000000000000000000000006528
144.0
CMS2_k127_3271658_24
Chemotaxis phosphatase CheX
K03409
-
-
0.000000000001102
75.0
CMS2_k127_3271658_3
anthranilate synthase component
K01657
-
4.1.3.27
1.165e-270
836.0
CMS2_k127_3271658_4
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K02886
-
-
0.0000000000000000000000000000003936
122.0
CMS2_k127_3317559_2
molybdopterin biosynthesis
K03750
-
2.10.1.1
4.529e-207
649.0
CMS2_k127_3317559_20
molybdopterin converting factor
K03636
-
-
0.000000000000000000000000000001777
122.0
CMS2_k127_3317559_21
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K11175
-
2.1.2.2
0.000000000000000000000000000003082
121.0
CMS2_k127_3317559_22
domain, Protein
-
-
-
0.000000000000000000000002527
120.0
CMS2_k127_3317559_23
molybdopterin biosynthesis
K03750
-
2.10.1.1
0.0000000000000000000003952
98.0
CMS2_k127_3317559_24
spectrin binding
-
-
-
0.00000000000000000002084
105.0
CMS2_k127_3317559_26
Protein of unknown function (DUF3365)
-
-
-
0.0000000000209
65.0
CMS2_k127_3317559_27
amino acid activation for nonribosomal peptide biosynthetic process
-
-
-
0.00000000008033
76.0
CMS2_k127_3317559_28
toxin-antitoxin pair type II binding
-
-
-
0.00000003855
57.0
CMS2_k127_3317559_3
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
3.74e-249
774.0
CMS2_k127_3603117_11
MiaB-like tRNA modifying enzyme
-
-
-
3.597e-238
739.0
CMS2_k127_3603117_12
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
3.248e-232
721.0
CMS2_k127_3603117_13
malic enzyme
K00027,K00029
-
1.1.1.38,1.1.1.40
3.82e-223
696.0
CMS2_k127_3603117_14
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
1.044e-208
651.0
CMS2_k127_3603117_15
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
2.103e-203
636.0
CMS2_k127_3603117_16
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.193e-247
770.0
CMS2_k127_3705941_1
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1497.0
CMS2_k127_3860749_1
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1021.0
CMS2_k127_3860749_20
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
Pili and flagellar-assembly chaperone, PapD N-terminal domain
K07346
-
-
0.00000000001181
74.0
CMS2_k127_3860749_3
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
4.184e-281
865.0
CMS2_k127_3860749_30
-
-
-
-
0.000003105
54.0
CMS2_k127_3860749_4
Single-stranded-DNA-specific exonuclease (RecJ)
K07462
-
-
7.863e-252
788.0
CMS2_k127_3860749_5
Belongs to the citrate synthase family
K01647
-
2.3.3.1
9.769e-248
768.0
CMS2_k127_3860749_6
pyridine nucleotide-disulfide oxidoreductase
K17218
-
1.8.5.4
4.419e-243
758.0
CMS2_k127_3860749_7
ATP synthase
K02412
-
3.6.3.14
1.171e-241
751.0
CMS2_k127_3860749_8
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
2.931e-207
647.0
CMS2_k127_3860749_9
WD40 repeats
-
-
-
1.707e-200
646.0
CMS2_k127_3868183_0
nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC
K02567
-
-
0.0
1760.0
CMS2_k127_3868183_1
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
1701.0
CMS2_k127_3868183_10
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
1.79e-276
859.0
CMS2_k127_3868183_70
COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.0000000000000000000000000000000004237
139.0
CMS2_k127_3868183_71
S4 domain
K14761
-
-
0.00000000000000000000000000004569
116.0
CMS2_k127_3868183_72
protein conserved in bacteria
-
-
-
0.0000000000000000000001539
98.0
CMS2_k127_3868183_73
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
7.152e-258
798.0
CMS2_k127_4221961_1
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
-
-
-
1.427e-226
714.0
CMS2_k127_4221961_10
Controls the rotational direction of flagella during chemotaxis
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530
-
-
0.000001944
59.0
CMS2_k127_4221961_15
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1439.0
CMS2_k127_4323462_2
ABC-type transport system involved in lipoprotein release permease component
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K03634
-
-
0.0000000000000000000000000000000001215
138.0
CMS2_k127_4370171_0
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1189.0
CMS2_k127_4370171_1
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
0.0
995.0
CMS2_k127_4370171_10
Belongs to the 'phage' integrase family
K03733
-
-
0.00000000000000000000000000000000000000006891
152.0
CMS2_k127_4370171_11
protein conserved in bacteria
-
-
-
0.00000000000001869
86.0
CMS2_k127_4370171_12
tyrosine recombinase
K04763
-
-
0.00000002064
58.0
CMS2_k127_4370171_2
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
calcium- and calmodulin-responsive adenylate cyclase activity
-
-
-
0.000000000000000000000000000000000000001787
161.0
CMS2_k127_4564738_9
Flagellar biosynthetic protein FliQ
K02420
-
-
0.000000000000000000000000000000000000003917
146.0
CMS2_k127_460311_0
cytochrome c
-
-
-
0.0
1482.0
CMS2_k127_460311_1
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1383.0
CMS2_k127_460311_10
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
1.301e-256
797.0
CMS2_k127_460311_11
Belongs to the GARS family
K01945
-
6.3.4.13
7.095e-255
788.0
CMS2_k127_460311_12
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
1.838e-246
765.0
CMS2_k127_460311_13
COG1055 Na H antiporter NhaD and related arsenite
-
-
-
2.068e-229
717.0
CMS2_k127_460311_14
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
K11784
-
1.21.98.1
5.954e-218
677.0
CMS2_k127_460311_15
surface antigen
-
-
-
6.979e-212
688.0
CMS2_k127_460311_16
3-deoxy-d-manno-octulosonic-acid transferase
K02527
-
2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15
7.765e-197
618.0
CMS2_k127_460311_17
Peptidase, M16
-
-
-
1.512e-196
620.0
CMS2_k127_460311_18
Belongs to the ALAD family
K01698
-
4.2.1.24
4.897e-195
610.0
CMS2_k127_460311_19
Belongs to the class-I aminoacyl-tRNA synthetase family
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
3.204e-316
975.0
CMS2_k127_460311_60
Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0000000000000000000000000000000000000000003472
159.0
CMS2_k127_460311_66
Transcriptional regulator
-
-
-
0.000000000000000000000000000000000000662
143.0
CMS2_k127_460311_67
-
-
-
-
0.00000000000000000000000000000000000516
142.0
CMS2_k127_460311_68
Cytochrome c
-
-
-
0.0000000000000000000000000000000003096
134.0
CMS2_k127_460311_69
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
K02884
-
-
0.000000000000000000000000000000001644
132.0
CMS2_k127_460311_7
Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
1.752e-314
977.0
CMS2_k127_460311_71
Zn_pept
-
-
-
0.00000000000000000000000000000002235
126.0
CMS2_k127_460311_72
Zn_pept
-
-
-
0.00000000000000000000000000001088
118.0
CMS2_k127_460311_73
endonuclease containing a URI domain
K07461
-
-
0.000000000000000000000000001017
113.0
CMS2_k127_460311_74
Belongs to the CsrA family
K03563
-
-
0.000000000000000000000000002222
112.0
CMS2_k127_460311_75
phosphorelay signal transduction system
-
-
-
0.00000000000000000000000000815
118.0
CMS2_k127_460311_76
Zn_pept
-
-
-
0.000000000000000000000004002
102.0
CMS2_k127_460311_77
Domain of unknown function (DUF4395)
-
-
-
0.000000000000000000000007145
106.0
CMS2_k127_460311_78
Zn_pept
-
-
-
0.00000000000000000000001186
101.0
CMS2_k127_460311_79
Zn_pept
-
-
-
0.00000000000000000000004989
99.0
CMS2_k127_460311_8
ATP-dependent DNA helicase
K03655
-
3.6.4.12
5.433e-293
908.0
CMS2_k127_460311_80
RDD family
-
-
-
0.000000000000000000003711
98.0
CMS2_k127_460311_81
-
-
-
-
0.00000000000000000236
89.0
CMS2_k127_460311_82
Peptidase dimerisation domain
K01295
-
3.4.17.11
0.0000000000000001653
81.0
CMS2_k127_460311_83
Zn_pept
-
-
-
0.00000000000000533
76.0
CMS2_k127_460311_84
Zn_pept
-
-
-
0.000000000005658
66.0
CMS2_k127_460311_85
Belongs to the glycosyl hydrolase 18 family
K01179,K01183
-
3.2.1.14,3.2.1.4
0.00000000008223
76.0
CMS2_k127_460311_88
Zn_pept
-
-
-
0.00000005565
55.0
CMS2_k127_460311_89
Belongs to the UPF0109 family
K06960
-
-
0.000001469
53.0
CMS2_k127_460311_9
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
1.484e-265
824.0
CMS2_k127_4630332_0
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Belongs to the small heat shock protein (HSP20) family
K13993
-
-
0.0000000000437
71.0
CMS2_k127_4630332_111
-
-
-
-
0.0000000009756
65.0
CMS2_k127_4630332_112
-
-
-
-
0.000000008022
64.0
CMS2_k127_4630332_114
-
-
-
-
0.000004329
51.0
CMS2_k127_4630332_117
DnaJ domain protein
K05801
-
-
0.00002146
55.0
CMS2_k127_4630332_118
Domain of unknown function (DUF4878)
-
-
-
0.0002345
49.0
CMS2_k127_4630332_12
PFAM peptidase M3A and M3B thimet oligopeptidase F
K01414
-
3.4.24.70
0.0
1010.0
CMS2_k127_4630332_13
YcaO cyclodehydratase, ATP-ad Mg2+-binding
K09136
-
-
6.706e-305
940.0
CMS2_k127_4630332_14
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
1.541e-286
883.0
CMS2_k127_4630332_15
4Fe-4S dicluster domain
K07307
-
-
6.878e-284
878.0
CMS2_k127_4630332_16
COG0631 Serine threonine protein phosphatase
K12132
-
2.7.11.1
8.915e-283
876.0
CMS2_k127_4630332_17
threonine synthase
K01733
-
4.2.3.1
3.685e-282
871.0
CMS2_k127_4630332_18
PFAM CheW domain protein
-
-
-
1.872e-270
857.0
CMS2_k127_4630332_19
COG0659 Sulfate permease and related
K03321
-
-
1.727e-262
815.0
CMS2_k127_4630332_2
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0
1605.0
CMS2_k127_4630332_20
Belongs to the MurCDEF family
K01924
-
6.3.2.8
9.737e-258
797.0
CMS2_k127_4630332_21
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
1.139e-253
786.0
CMS2_k127_4630332_22
COG2223 Nitrate nitrite transporter
K02575
-
-
6.253e-249
771.0
CMS2_k127_4630332_23
o-acetylhomoserine
K01740
-
2.5.1.49
4.119e-243
754.0
CMS2_k127_4630332_24
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
3.416e-231
719.0
CMS2_k127_4630332_25
2-nitropropane dioxygenase
K00459
-
1.13.12.16
1.315e-220
685.0
CMS2_k127_4630332_26
S-adenosylmethionine-dependent methyltransferase
-
-
-
1.058e-216
676.0
CMS2_k127_4630332_27
Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K00641
-
2.3.1.31
8.733e-213
663.0
CMS2_k127_4630332_28
Belongs to the SEDS family
K05837
-
-
2.325e-208
652.0
CMS2_k127_4630332_29
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
1.409e-207
651.0
CMS2_k127_4630332_3
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1587.0
CMS2_k127_4630332_30
phosphohydrolase (DHH superfamily)
K07097
-
-
4.462e-207
647.0
CMS2_k127_4630332_31
PFAM HI0933 family protein
K07007
-
-
2.965e-205
643.0
CMS2_k127_4630332_32
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1211.0
CMS2_k127_4630332_60
Catalyzes the reversible phosphorylation of UMP to UDP
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K02956
-
-
0.00000000000000000000000000000000000000000004426
161.0
CMS2_k127_4789816_0
Cytochrome C oxidase subunit II, periplasmic domain
K00376
-
1.7.2.4
0.0
1570.0
CMS2_k127_4789816_1
hydrogenase (NiFe) small subunit HydA
K05927
-
1.12.5.1
0.0
1367.0
CMS2_k127_4789816_10
periplasmic copper-binding protein NosD
K07218
-
-
8.959e-213
665.0
CMS2_k127_4789816_11
transporter
K14445
-
-
3.597e-212
666.0
CMS2_k127_4789816_12
Histidine kinase-like ATPases
-
-
-
3.455e-209
661.0
CMS2_k127_4789816_13
FtsX-like permease family
-
-
-
6.204e-197
619.0
CMS2_k127_4789816_14
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
5.695e-215
670.0
CMS2_k127_4789816_8
peptidylprolyl isomerase
K03770
-
5.2.1.8
1.549e-214
676.0
CMS2_k127_4789816_9
Hydrogenase-4, component G
K14090
-
-
3.722e-213
664.0
CMS2_k127_489427_0
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
2.835e-255
788.0
CMS2_k127_489427_20
Phage integrase family
-
-
-
0.000000000000000000000000000000001334
136.0
CMS2_k127_489427_22
PFAM Plasmid maintenance system killer
K07334
-
-
0.000004529
52.0
CMS2_k127_489427_24
Belongs to the 'phage' integrase family
-
-
-
0.0004496
52.0
CMS2_k127_489427_3
N-6 DNA Methylase
K03427
-
2.1.1.72
3.8e-236
749.0
CMS2_k127_489427_4
ubiquinol cytochrome c oxidoreductase, cytochrome c1
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1444.0
CMS2_k127_5049733_1
GTP-binding protein
K06207
-
-
0.0
1175.0
CMS2_k127_5049733_10
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.00000000000000000000000000000000006755
133.0
CMS2_k127_5049733_3
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
7.714e-241
748.0
CMS2_k127_5049733_4
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
1.396e-231
721.0
CMS2_k127_5049733_5
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
7.379e-206
642.0
CMS2_k127_5049733_6
Belongs to the dGTPase family. Type 2 subfamily
K01129
-
3.1.5.1
8.795e-202
632.0
CMS2_k127_5049733_7
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COG2931, RTX toxins and related Ca2 -binding proteins
-
-
-
0.000000000000000000000000000008991
138.0
CMS2_k127_5191033_74
SCO1/SenC
K07152
-
-
0.000000000000000000000000000388
121.0
CMS2_k127_5191033_77
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
K03117
-
-
0.000000000000000000000002671
107.0
CMS2_k127_5191033_79
-
-
-
-
0.0000000000001707
76.0
CMS2_k127_5191033_8
Belongs to the aspartokinase family
K00928
-
2.7.2.4
6.673e-221
689.0
CMS2_k127_5191033_82
M6 family metalloprotease domain protein
K09607
-
-
0.0004237
48.0
CMS2_k127_5191033_9
TonB-dependent receptor
K02014
-
-
1.084e-216
689.0
CMS2_k127_5230615_0
domain protein
K09944
-
-
4.402e-233
728.0
CMS2_k127_5230615_1
mechanosensitive ion channel
-
-
-
6.941e-202
637.0
CMS2_k127_5230615_10
-
-
-
-
0.00000000000000000000591
94.0
CMS2_k127_5230615_2
Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.00000000000000000000000000000000000004365
143.0
CMS2_k127_5330325_25
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.00000000000000000000000000001679
117.0
CMS2_k127_5330325_26
Preprotein translocase
K03210
-
-
0.0000000000000000000002882
99.0
CMS2_k127_5330325_3
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K15633
-
5.4.2.12
1.069e-269
835.0
CMS2_k127_5330325_4
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
2.563e-246
763.0
CMS2_k127_5330325_5
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
6.49e-213
665.0
CMS2_k127_5330325_6
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1180.0
CMS2_k127_5380824_1
Nitroreductase family
-
-
-
6.924e-257
799.0
CMS2_k127_5380824_10
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
5.358e-242
751.0
CMS2_k127_5380824_40
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.00000000000000000000000000000000000000000139
164.0
CMS2_k127_5380824_53
-
-
-
-
0.000000000000000000000000000000000000000004388
154.0
CMS2_k127_5380824_54
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.00000000000000000000000000000000000000001233
153.0
CMS2_k127_5380824_55
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.00000000000000000000000000000000000000006092
151.0
CMS2_k127_5380824_56
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K02895
-
-
0.0000000000000000000000000000000000000008661
149.0
CMS2_k127_5380824_57
-
-
-
-
0.000000000000000000000000000000000000003173
153.0
CMS2_k127_5380824_58
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
K02892
-
-
0.0000000000000000000000000000000002832
131.0
CMS2_k127_5380824_59
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K02954
-
-
0.000000000000000000000000000000007548
127.0
CMS2_k127_5380824_6
Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K03893
-
-
8.148e-227
707.0
CMS2_k127_5380824_60
Thioredoxin
-
-
-
0.0000000000000000000000000000001697
124.0
CMS2_k127_5380824_63
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.000000000000002748
76.0
CMS2_k127_5380824_7
Aldo/keto reductase family
-
-
-
4.751e-212
664.0
CMS2_k127_5380824_8
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
5.062e-197
624.0
CMS2_k127_5380824_9
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
1.029e-231
719.0
CMS2_k127_5384377_31
iron ion homeostasis
K04758
-
-
0.00000000000000000000000000002971
118.0
CMS2_k127_5384377_32
Belongs to the bacterial ribosomal protein bL32 family
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
-
-
-
1.048e-209
658.0
CMS2_k127_5384377_7
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K00648
-
2.3.1.180
3.604e-195
611.0
CMS2_k127_5384377_8
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase
K15022
-
1.17.1.10
0.0
1255.0
CMS2_k127_5402480_10
Belongs to the SEDS family
K03588
-
-
3.503e-209
654.0
CMS2_k127_5402480_11
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit
K00341
-
1.6.5.3
0.0
1117.0
CMS2_k127_5402480_30
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)
K00342
-
1.6.5.3
3.669e-290
895.0
CMS2_k127_5402480_7
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
6.154e-278
859.0
CMS2_k127_5402480_8
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
2.653e-268
826.0
CMS2_k127_5402480_9
Nucleotidyltransferase DNA polymerase involved in DNA repair
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1335.0
CMS2_k127_5909588_1
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
K00820
-
2.6.1.16
0.0
1077.0
CMS2_k127_5909588_10
Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K00012
-
1.1.1.22
3.739e-206
646.0
CMS2_k127_5909588_11
Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K03147
-
4.1.99.17
6.305e-296
909.0
CMS2_k127_5909588_5
FGGY family of carbohydrate kinases, N-terminal domain
K11216
-
2.7.1.189
5.085e-281
869.0
CMS2_k127_5909588_6
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
K00955,K00956
-
2.7.1.25,2.7.7.4
2.38e-264
818.0
CMS2_k127_5909588_7
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
3.713e-226
704.0
CMS2_k127_5909588_8
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
K03593
-
-
7.503e-222
690.0
CMS2_k127_5909588_9
Belongs to the GPI family
K01810
-
5.3.1.9
2.594e-221
690.0
CMS2_k127_6149223_0
Nitrogenase cofactor biosynthesis protein NifB
K02585
-
-
6.405e-264
817.0
CMS2_k127_6149223_1
Nitrogenase protein alpha chain
K02586
-
1.18.6.1
1.161e-207
649.0
CMS2_k127_6149223_2
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
-
-
-
0.0
2197.0
CMS2_k127_6608531_1
Belongs to the ClpA ClpB family
K03694,K03695
-
-
0.0
1464.0
CMS2_k127_6608531_10
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
2.517e-231
723.0
CMS2_k127_6608531_11
HD domain
-
-
-
4.019e-228
713.0
CMS2_k127_6608531_12
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
2.231e-213
669.0
CMS2_k127_6608531_13
Flagellar Assembly Protein A
-
-
-
9.542e-210
665.0
CMS2_k127_6608531_14
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
6.043e-209
651.0
CMS2_k127_6608531_15
Aminotransferase, class I
K14155
-
4.4.1.8
1.521e-206
647.0
CMS2_k127_6608531_16
fructose-bisphosphate aldolase
K01624
-
4.1.2.13
3.455e-199
623.0
CMS2_k127_6608531_17
Belongs to the heme-copper respiratory oxidase family
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
4.285e-265
826.0
CMS2_k127_6608531_60
DNA-binding protein
-
-
-
0.000000000000000000000000000000000000004114
146.0
CMS2_k127_6608531_61
-
-
-
-
0.0000000000000000000000000000000000005835
142.0
CMS2_k127_6608531_62
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.0000000000000000000000000000000000147
136.0
CMS2_k127_6608531_63
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
K03536
-
3.1.26.5
0.00000000000000000000000000000000002249
137.0
CMS2_k127_6608531_64
Protein of unknown function (DUF3373)
-
-
-
0.0000000000000000000000000000000002958
148.0
CMS2_k127_6608531_65
-
-
-
-
0.000000000000000000000000009349
110.0
CMS2_k127_6608531_66
-
-
-
-
0.00000000000000000000000007414
107.0
CMS2_k127_6608531_67
Transposase, Mutator family
-
-
-
0.0000000000000000000000009379
105.0
CMS2_k127_6608531_69
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.000000000000000005795
84.0
CMS2_k127_6608531_7
Histidine kinase
K03407
-
2.7.13.3
3.767e-260
818.0
CMS2_k127_6608531_72
Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.189e-249
773.0
CMS2_k127_6630889_0
Mitochondrial degradasome RNA helicase subunit C terminal
K17675
-
3.6.4.13
0.0
1359.0
CMS2_k127_6630889_1
HD domain
-
-
-
0.0
1257.0
CMS2_k127_6630889_10
chemotaxis protein
K03406
-
-
1.261e-209
664.0
CMS2_k127_6630889_11
-
-
-
-
4.244e-195
615.0
CMS2_k127_6630889_12
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K02015
-
-
0.00000000000000000000000004648
108.0
CMS2_k127_6630889_49
-
-
-
-
0.0000000000000000001908
89.0
CMS2_k127_6630889_5
Radical SAM
-
-
-
1.902e-258
803.0
CMS2_k127_6630889_51
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
0.00000000134
61.0
CMS2_k127_6630889_6
fumarate reductase, flavoprotein subunit
K00239
-
1.3.5.1,1.3.5.4
1.508e-254
794.0
CMS2_k127_6630889_7
LapD/MoxY periplasmic domain
-
-
-
2.031e-246
776.0
CMS2_k127_6630889_8
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
5.393e-240
748.0
CMS2_k127_6630889_9
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
3.526e-237
736.0
CMS2_k127_6881686_0
RNA binding S1 domain protein
K06959
-
-
0.0
1144.0
CMS2_k127_6881686_1
nitrite reductase
K15864
-
1.7.2.1,1.7.99.1
0.0
1047.0
CMS2_k127_6881686_10
Acts as a magnesium transporter
K06213
-
-
1.268e-225
706.0
CMS2_k127_6881686_11
Heme d1 biosynthesis protein NirF
K19345
-
-
8.266e-215
670.0
CMS2_k127_6881686_12
Major Facilitator Superfamily
-
-
-
2.886e-207
649.0
CMS2_k127_6881686_13
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
3.327e-250
774.0
CMS2_k127_6881686_7
Belongs to the DEAD box helicase family
K05591
-
3.6.4.13
2.282e-249
775.0
CMS2_k127_6881686_8
Metallo-beta-lactamase superfamily
-
-
-
1.447e-244
763.0
CMS2_k127_6881686_9
Heme d1 biosynthesis protein NirJ
-
-
-
2.422e-234
726.0
CMS2_k127_6883445_0
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
3.133e-280
864.0
CMS2_k127_6883445_1
potassium channel protein
K10716
-
-
1.414e-260
810.0
CMS2_k127_6883445_10
-
-
-
-
0.0000000000000000000000000000005867
123.0
CMS2_k127_6883445_11
RelE-like toxin of type II toxin-antitoxin system HigB
K07334
-
-
0.000000000000000000000001322
105.0
CMS2_k127_6883445_12
ParE toxin of type II toxin-antitoxin system, parDE
-
-
-
0.000000000000000000002412
96.0
CMS2_k127_6883445_2
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
-
-
-
4.498e-198
625.0
CMS2_k127_6883445_3
Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
6.337e-222
691.0
CMS2_k127_6898325_40
methyl-accepting chemotaxis protein
K03406
-
-
0.000000000000000000000000000000000001113
160.0
CMS2_k127_6898325_41
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
-
-
-
0.0000000000000000000000000000000004286
143.0
CMS2_k127_6898325_42
Psort location Cytoplasmic, score 8.96
-
-
-
0.000000000000000000000000000000006104
149.0
CMS2_k127_6898325_43
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
-
-
-
0.0000000000000000000000000000002634
136.0
CMS2_k127_6898325_44
HD domain
-
-
-
0.00000000000000000000000000000608
138.0
CMS2_k127_6898325_45
phosphate-selective porin O and P
-
-
-
0.0000000000008932
79.0
CMS2_k127_6898325_46
-
-
-
-
0.000000000003756
71.0
CMS2_k127_6898325_47
Protein of unknown function (DUF2798)
-
-
-
0.000000001028
62.0
CMS2_k127_6898325_48
Psort location Cytoplasmic, score 8.96
-
-
-
0.00000001691
63.0
CMS2_k127_6898325_49
COG0226 ABC-type phosphate transport system, periplasmic component
-
-
-
0.00000001819
61.0
CMS2_k127_6898325_5
Belongs to the DegT DnrJ EryC1 family
K13017
-
2.6.1.98
9.417e-200
625.0
CMS2_k127_6898325_51
-
-
-
-
0.000002458
54.0
CMS2_k127_6898325_6
signal transduction protein containing a membrane domain an EAL and a GGDEF domain
-
-
-
3.781e-196
636.0
CMS2_k127_6898325_7
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
K01465
-
3.5.2.3
3.842e-194
612.0
CMS2_k127_6898325_8
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
2.529e-248
769.0
CMS2_k127_690433_1
Participates in both transcription termination and antitermination
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K13378
-
1.6.5.3
3.502e-216
683.0
CMS2_k127_6985468_1
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00330
-
1.6.5.3
0.000000000000000000000000000007551
122.0
CMS2_k127_6985468_18
Rhs Element Vgr Protein
K11904
-
-
0.00000000000000000000000000002335
128.0
CMS2_k127_6985468_19
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00340
-
1.6.5.3
0.0000000000000000001863
92.0
CMS2_k127_6985468_2
COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
K12506
-
2.7.7.60,4.6.1.12
0.00000000000000000000000000001883
117.0
CMS2_k127_7017471_3
transcriptional regulator
-
-
-
0.0000003754
61.0
CMS2_k127_70547_0
Glutamate synthase
K00265
-
1.4.1.13,1.4.1.14
0.0
2525.0
CMS2_k127_70547_1
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K00901
-
2.7.1.107
0.00000000000000000000000000000000000000000001733
164.0
CMS2_k127_70547_147
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.0000000000000000000000000000000000000000002953
159.0
CMS2_k127_70547_148
Belongs to the ArsC family
-
-
-
0.000000000000000000000000000000000000000007927
156.0
CMS2_k127_70547_149
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.00000000000000000000000000000000000000001052
162.0
CMS2_k127_70547_15
Glutamate synthase
K00266
-
1.4.1.13,1.4.1.14
3.554e-269
832.0
CMS2_k127_70547_150
Domain of unknown function (DUF3817)
-
-
-
0.00000000000000000000000000000000000000001055
154.0
CMS2_k127_70547_151
Diguanylate cyclase
-
-
-
0.0000000000000000000000000000000000000001024
170.0
CMS2_k127_70547_152
Cold-shock protein
K03704
-
-
0.000000000000000000000000000000000000001712
148.0
CMS2_k127_70547_153
-
-
-
-
0.000000000000000000000000000000000000002895
148.0
CMS2_k127_70547_154
Histidine kinase
-
-
-
0.00000000000000000000000000000000000002711
148.0
CMS2_k127_70547_155
domain protein
-
-
-
0.000000000000000000000000000000000003212
158.0
CMS2_k127_70547_156
S4 domain protein
-
-
-
0.0000000000000000000000000000000001056
133.0
CMS2_k127_70547_157
of the cytoplasmic domain of flagellar protein FhlB
K04061
-
-
0.0000000000000000000000000000000003487
132.0
CMS2_k127_70547_158
Rhodanese Homology Domain
-
-
-
0.0000000000000000000000000000000007946
136.0
CMS2_k127_70547_159
-
-
-
-
0.0000000000000000000000000000000052
141.0
CMS2_k127_70547_16
4Fe-4S binding domain
-
-
-
4.713e-269
833.0
CMS2_k127_70547_160
Domain of unknown function (DUF1987)
-
-
-
0.00000000000000000000000000000001144
130.0
CMS2_k127_70547_161
Diguanylate cyclase
-
-
-
0.00000000000000000000000000000001272
147.0
CMS2_k127_70547_162
-
-
-
-
0.0000000000000000000000000000000717
133.0
CMS2_k127_70547_163
COG1734 DnaK suppressor protein
K06204
-
-
0.0000000000000000000000000000001722
126.0
CMS2_k127_70547_165
-
-
-
-
0.0000000000000000000000000007403
113.0
CMS2_k127_70547_166
Oxaloacetate decarboxylase, gamma chain
K01573
-
4.1.1.3
0.00000000000000000000002028
101.0
CMS2_k127_70547_168
helix_turn_helix, Lux Regulon
-
-
-
0.000000000000000000001488
102.0
CMS2_k127_70547_169
Anaerobic ribonucleoside-triphosphate reductase
-
-
-
0.0000000000000000000101
92.0
CMS2_k127_70547_17
Flagellar Assembly Protein A
-
-
-
3.819e-266
832.0
CMS2_k127_70547_170
Rhodanese Homology Domain
-
-
-
0.0000000000001751
81.0
CMS2_k127_70547_171
-
-
-
-
0.000000000002015
77.0
CMS2_k127_70547_173
Leucine-rich repeat (LRR) protein
-
-
-
0.0000000001626
70.0
CMS2_k127_70547_174
Domain of unknown function DUF302
-
-
-
0.00000005421
60.0
CMS2_k127_70547_175
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.0000002778
52.0
CMS2_k127_70547_177
-
-
-
-
0.00009202
45.0
CMS2_k127_70547_18
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
2.221e-256
795.0
CMS2_k127_70547_19
COG1883 Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K01572
-
4.1.1.3
3.307e-247
767.0
CMS2_k127_70547_2
AcrB/AcrD/AcrF family
-
-
-
0.0
1573.0
CMS2_k127_70547_20
Mur ligase middle domain
K01929
-
6.3.2.10
4.021e-247
769.0
CMS2_k127_70547_21
Belongs to the peptidase M16 family
-
-
-
1.281e-242
753.0
CMS2_k127_70547_22
Saccharopine dehydrogenase
K00290
-
1.5.1.7
7.516e-242
749.0
CMS2_k127_70547_23
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03092
-
-
8.482e-237
736.0
CMS2_k127_70547_24
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
7.891e-230
720.0
CMS2_k127_70547_25
Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily
K13747
-
4.1.1.96
6.683e-229
711.0
CMS2_k127_70547_26
AAA domain
-
-
-
2.648e-228
731.0
CMS2_k127_70547_27
histidyl-tRNA synthetase
K01892
-
6.1.1.21
4.672e-227
706.0
CMS2_k127_70547_28
WD40 repeats
-
-
-
6.881e-225
717.0
CMS2_k127_70547_29
PFAM AMP-dependent synthetase and ligase
K01897
-
6.2.1.3
2.912e-222
700.0
CMS2_k127_70547_3
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.0
1493.0
CMS2_k127_70547_30
TRAP transporter, DctM subunit
-
-
-
8.771e-220
687.0
CMS2_k127_70547_31
Aminotransferase
K00812
-
2.6.1.1
2.309e-218
681.0
CMS2_k127_70547_32
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
9.16e-216
674.0
CMS2_k127_70547_33
-
-
-
-
8.483e-213
669.0
CMS2_k127_70547_34
signal transduction protein containing a membrane domain an EAL and a GGDEF domain
-
-
-
6.199e-211
674.0
CMS2_k127_70547_35
HI0933-like protein
K07007
-
-
8.293e-209
655.0
CMS2_k127_70547_36
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00821
-
2.6.1.11,2.6.1.17
3.961e-207
649.0
CMS2_k127_70547_37
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
1.916e-246
765.0
CMS2_k127_7093264_4
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
8.71e-239
743.0
CMS2_k127_7093264_5
Belongs to the DegT DnrJ EryC1 family
K15895
-
2.6.1.92
3.035e-198
622.0
CMS2_k127_7093264_6
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
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5.624e-241
753.0
CMS2_k127_78547_10
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
