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Overview

ID MAG00478
Name CMS2_bin.96
Sample SMP0011
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus Methanocrinis
Species Methanocrinis harundinacea_A
Assembly information
Completeness (%) 85.25
Contamination (%) 2.37
GC content (%) 57.0
N50 (bp) 8,229
Genome size (bp) 1,974,903

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1920

Gene name Description KEGG GOs EC E-value Score Sequence
CMS2_k127_1012572_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 548.0
CMS2_k127_1012572_1 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 526.0
CMS2_k127_1012572_2 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 492.0
CMS2_k127_1012572_3 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 465.0
CMS2_k127_1012572_4 Protein of unknown function DUF262 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 353.0
CMS2_k127_1012572_5 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 323.0
CMS2_k127_1012572_6 Involved in protein export K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000832 270.0
CMS2_k127_1014526_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008721 271.0
CMS2_k127_1014526_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.0000000000000000000000000000000000000000000002945 192.0
CMS2_k127_1021167_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 371.0
CMS2_k127_1021167_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 344.0
CMS2_k127_1021167_10 - - - - 0.0000000000000001861 84.0
CMS2_k127_1021167_11 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000001307 72.0
CMS2_k127_1021167_12 protein conserved in archaea K09723 - - 0.00002289 54.0
CMS2_k127_1021167_2 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 305.0
CMS2_k127_1021167_3 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 303.0
CMS2_k127_1021167_4 transport K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008515 272.0
CMS2_k127_1021167_5 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000006195 227.0
CMS2_k127_1021167_6 binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000001838 139.0
CMS2_k127_1021167_7 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000004454 109.0
CMS2_k127_1021167_8 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000000004442 96.0
CMS2_k127_1021167_9 Tetratricopeptide repeat - - - 0.000000000000000001643 95.0
CMS2_k127_1056294_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.223e-245 767.0
CMS2_k127_1056294_1 TIGRFAM transposase, IS605 OrfB family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 386.0
CMS2_k127_1056294_2 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA K00584 - 2.1.1.86 0.000000000000000000000000000000001635 133.0
CMS2_k127_1060044_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006946 580.0
CMS2_k127_1061152_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 584.0
CMS2_k127_1061152_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 494.0
CMS2_k127_1061152_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 438.0
CMS2_k127_1061152_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 330.0
CMS2_k127_1061152_4 PUA domain containing protein K07398 - - 0.00000000000000000000000000000000000000000004059 165.0
CMS2_k127_1061152_5 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000007701 154.0
CMS2_k127_1061152_6 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.000000000000000000000002265 110.0
CMS2_k127_1066699_0 RDD family - - - 0.0000000000000000000000000000000000001411 147.0
CMS2_k127_1066699_1 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000001866 116.0
CMS2_k127_1066699_2 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000001992 60.0
CMS2_k127_1093431_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 2.465e-199 633.0
CMS2_k127_1093431_1 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 383.0
CMS2_k127_1093431_2 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004208 258.0
CMS2_k127_1093431_3 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002627 239.0
CMS2_k127_1093431_4 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000006409 183.0
CMS2_k127_1093431_5 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000009559 147.0
CMS2_k127_1093431_6 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000002519 144.0
CMS2_k127_1093431_7 PAC2 family K07159 - - 0.000000000000000000002141 103.0
CMS2_k127_1097737_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1083.0
CMS2_k127_1097737_1 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000006262 223.0
CMS2_k127_1097737_2 Thioredoxin - - - 0.0000000000000000000000000000000000000001875 154.0
CMS2_k127_1097737_3 Dodecin K09165 - - 0.0000000000000000000003573 98.0
CMS2_k127_1098012_0 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000001211 178.0
CMS2_k127_1098012_1 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000000761 164.0
CMS2_k127_1098012_2 Thioredoxin K03671 - - 0.000000000000000000000009775 106.0
CMS2_k127_1098012_3 - - - - 0.00000008592 59.0
CMS2_k127_1140401_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 9.182e-289 908.0
CMS2_k127_1140401_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008252 473.0
CMS2_k127_1140401_2 PFAM nucleoside recognition domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009542 239.0
CMS2_k127_1140401_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000004493 175.0
CMS2_k127_1140401_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.0000000000000000000000000000000000006837 147.0
CMS2_k127_1140401_5 self proteolysis - - - 0.0000000001734 73.0
CMS2_k127_1150445_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 454.0
CMS2_k127_1150445_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 302.0
CMS2_k127_1150445_2 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000003346 222.0
CMS2_k127_1150445_3 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000529 213.0
CMS2_k127_1150445_4 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000007684 178.0
CMS2_k127_1150445_5 - - - - 0.000000000000000000000000000000000006185 143.0
CMS2_k127_1150445_6 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000000000000006107 108.0
CMS2_k127_1150445_7 Protein of unknown function (DUF2953) - - - 0.00008575 52.0
CMS2_k127_1175264_0 Glycogen debranching enzyme N terminal - - - 0.00000000000000000000000000009019 117.0
CMS2_k127_1175264_1 polysaccharide biosynthetic process - - - 0.000000000000000003616 95.0
CMS2_k127_1175264_2 Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000002114 79.0
CMS2_k127_1209180_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.007e-277 872.0
CMS2_k127_1209180_1 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004366 366.0
CMS2_k127_1209180_2 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004991 330.0
CMS2_k127_1209180_3 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000118 199.0
CMS2_k127_1209180_4 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000001183 195.0
CMS2_k127_1210111_0 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000002141 268.0
CMS2_k127_1210111_1 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000005803 211.0
CMS2_k127_1210111_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K14387 - - 0.000000000000000000000000000000000000000000000000000000002669 216.0
CMS2_k127_1210111_3 Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000003279 170.0
CMS2_k127_1210111_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000000003739 130.0
CMS2_k127_1210111_5 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000004063 126.0
CMS2_k127_1210111_6 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000003192 123.0
CMS2_k127_1210111_7 Possibly the antitoxin component of a - - - 0.0000000000000000001125 91.0
CMS2_k127_1272532_0 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001428 261.0
CMS2_k127_1272532_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000006624 234.0
CMS2_k127_1272532_2 PFAM alpha beta hydrolase fold - - - 0.0000006825 53.0
CMS2_k127_1274110_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000007832 241.0
CMS2_k127_1274110_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000000881 224.0
CMS2_k127_1274110_2 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000004514 144.0
CMS2_k127_1316911_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 518.0
CMS2_k127_1316911_1 AAA domain (Cdc48 subfamily) K07392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 425.0
CMS2_k127_1316911_10 Lactonase, 7-bladed beta-propeller - - - 0.000000000000006346 88.0
CMS2_k127_1316911_11 Conserved repeat domain K01179 - 3.2.1.4 0.0000000000006278 80.0
CMS2_k127_1316911_12 Protein of unknown function (DUF3795) - - - 0.000002042 52.0
CMS2_k127_1316911_13 Periplasmic copper-binding protein (NosD) - - - 0.000002799 57.0
CMS2_k127_1316911_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 291.0
CMS2_k127_1316911_3 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008146 273.0
CMS2_k127_1316911_4 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001181 243.0
CMS2_k127_1316911_5 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000001301 196.0
CMS2_k127_1316911_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000002316 189.0
CMS2_k127_1316911_7 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000000000001701 162.0
CMS2_k127_1316911_8 Fibronectin type III domain - - - 0.0000000000000000000000000000001344 141.0
CMS2_k127_1316911_9 Pentapeptide repeat K15352,K18555 - - 0.0000000000000000001751 101.0
CMS2_k127_1358402_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1039.0
CMS2_k127_1358402_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000007868 217.0
CMS2_k127_1358402_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000000000000000000000001115 175.0
CMS2_k127_1358402_3 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000000003231 134.0
CMS2_k127_1358402_4 PFAM ferredoxin-dependent glutamate synthase - - - 0.0000000000000004765 78.0
CMS2_k127_1363797_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 2.95e-196 637.0
CMS2_k127_1363797_1 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 611.0
CMS2_k127_1363797_10 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000001874 232.0
CMS2_k127_1363797_11 PAS domain K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000216 248.0
CMS2_k127_1363797_12 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000006882 228.0
CMS2_k127_1363797_13 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000001056 214.0
CMS2_k127_1363797_14 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000009763 161.0
CMS2_k127_1363797_15 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000001698 128.0
CMS2_k127_1363797_16 Secreted repeat of unknown function - - - 0.0000000000000000000000000001601 119.0
CMS2_k127_1363797_17 Belongs to the GbsR family - - - 0.00000000000001213 81.0
CMS2_k127_1363797_18 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000001145 69.0
CMS2_k127_1363797_19 Domain of unknown function (DUF378) - - - 0.0000001749 55.0
CMS2_k127_1363797_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 473.0
CMS2_k127_1363797_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 411.0
CMS2_k127_1363797_4 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 370.0
CMS2_k127_1363797_5 PFAM Bile acid sodium symporter K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 361.0
CMS2_k127_1363797_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 316.0
CMS2_k127_1363797_7 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006375 263.0
CMS2_k127_1363797_8 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002623 251.0
CMS2_k127_1363797_9 transferase activity, transferring glycosyl groups K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000002515 259.0
CMS2_k127_1374235_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.465e-248 777.0
CMS2_k127_1374235_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 6.488e-231 721.0
CMS2_k127_1374235_10 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000001482 173.0
CMS2_k127_1374235_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000001267 95.0
CMS2_k127_1374235_12 ATP synthase subunit C K02124 - - 0.000000000000000000305 89.0
CMS2_k127_1374235_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000001134 74.0
CMS2_k127_1374235_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 590.0
CMS2_k127_1374235_3 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 467.0
CMS2_k127_1374235_4 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 453.0
CMS2_k127_1374235_5 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 388.0
CMS2_k127_1374235_6 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 364.0
CMS2_k127_1374235_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 296.0
CMS2_k127_1374235_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000002681 239.0
CMS2_k127_1374235_9 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000009055 170.0
CMS2_k127_1376205_0 Carbohydrate phosphorylase K00688,K16153 - 2.4.1.1,2.4.1.11 9.191e-270 848.0
CMS2_k127_1376205_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 7.179e-239 749.0
CMS2_k127_1376205_2 Carbohydrate phosphorylase K00688,K16153 - 2.4.1.1,2.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 547.0
CMS2_k127_1376205_3 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000008683 239.0
CMS2_k127_1376205_4 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000000000000000000000000000000000000000003446 219.0
CMS2_k127_1376205_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000009236 201.0
CMS2_k127_1398953_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 340.0
CMS2_k127_1431396_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 381.0
CMS2_k127_1431396_1 PFAM phosphoesterase, RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005018 267.0
CMS2_k127_1431396_2 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000003036 173.0
CMS2_k127_1431396_3 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.0000000006523 62.0
CMS2_k127_1458476_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 370.0
CMS2_k127_1458476_1 Phenazine biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006502 349.0
CMS2_k127_1458476_2 racemase activity, acting on amino acids and derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 289.0
CMS2_k127_1458476_3 alginic acid biosynthetic process K20276 - - 0.0000000000000000000000000000000000000000004456 183.0
CMS2_k127_1458476_5 PFAM Transglycosylase-associated protein - - - 0.00000000000000000000000007797 108.0
CMS2_k127_1458476_6 Acetyltransferase (GNAT) domain - - - 0.00004089 53.0
CMS2_k127_1467711_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 561.0
CMS2_k127_1467711_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 430.0
CMS2_k127_1467711_2 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000000000000000000000000000000007988 234.0
CMS2_k127_1467711_3 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000007358 219.0
CMS2_k127_1467711_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000003277 174.0
CMS2_k127_1467711_5 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000000000000005251 147.0
CMS2_k127_1467711_6 - - - - 0.000000000000000000000000000000000004771 148.0
CMS2_k127_1467711_7 Has ATPase and non-specific DNA-binding activities K07456 - - 0.000000000000000000000000004036 123.0
CMS2_k127_1467711_8 - - - - 0.0000000000000000003062 98.0
CMS2_k127_1467711_9 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000000006226 62.0
CMS2_k127_1468586_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 1.897e-208 666.0
CMS2_k127_1468586_1 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 310.0
CMS2_k127_1468586_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000004804 184.0
CMS2_k127_1468586_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000001951 140.0
CMS2_k127_1468586_4 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.000000000000000000009818 94.0
CMS2_k127_1468586_5 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.00000000000000006875 82.0
CMS2_k127_1518601_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.406e-217 687.0
CMS2_k127_1518601_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 472.0
CMS2_k127_1518601_2 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.0000000000000000000000000002174 121.0
CMS2_k127_1518601_3 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000007216 86.0
CMS2_k127_1520692_0 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 473.0
CMS2_k127_1520692_1 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000000000009556 156.0
CMS2_k127_1520692_2 PFAM Cache, type 2 domain protein - - - 0.0000000000000000002133 92.0
CMS2_k127_1574070_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1122.0
CMS2_k127_1574070_1 Transposase DDE domain K07495 - - 0.00000000000000000000000000000000004043 136.0
CMS2_k127_1574070_2 Transposase DDE domain K07495 - - 0.0002999 44.0
CMS2_k127_1580654_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000001161 182.0
CMS2_k127_1601337_0 malic enzyme K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 357.0
CMS2_k127_1601337_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 353.0
CMS2_k127_1601337_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 329.0
CMS2_k127_1601337_3 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 307.0
CMS2_k127_1601337_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 297.0
CMS2_k127_1601337_5 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000276 247.0
CMS2_k127_1601337_6 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000002625 182.0
CMS2_k127_1601337_7 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000000000006027 116.0
CMS2_k127_1601337_8 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.0000000000000000002443 87.0
CMS2_k127_16352_0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 296.0
CMS2_k127_16352_1 eRF1 domain 2 - - - 0.00000000000000000000000000000000003278 147.0
CMS2_k127_16352_2 PFAM Leucine rich repeat variant - - - 0.0000000000107 72.0
CMS2_k127_1720322_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 320.0
CMS2_k127_1720322_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002195 288.0
CMS2_k127_1720322_2 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000001339 171.0
CMS2_k127_1720322_3 Acetyltransferase (GNAT) domain K03830 - - 0.00000000000000000000000000000000000001525 151.0
CMS2_k127_17416_0 Has ATPase and non-specific DNA-binding activities K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006595 404.0
CMS2_k127_1828588_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 609.0
CMS2_k127_1828588_1 phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 412.0
CMS2_k127_1828588_10 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000002913 147.0
CMS2_k127_1828588_11 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000403 112.0
CMS2_k127_1828588_12 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000009596 107.0
CMS2_k127_1828588_13 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000001419 102.0
CMS2_k127_1828588_14 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000005699 74.0
CMS2_k127_1828588_15 COG2157 Ribosomal protein L20A (L18A) K02944 - - 0.0001356 48.0
CMS2_k127_1828588_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 406.0
CMS2_k127_1828588_3 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 385.0
CMS2_k127_1828588_4 PFAM NB-ARC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001345 267.0
CMS2_k127_1828588_5 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000000000005249 238.0
CMS2_k127_1828588_6 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000002878 196.0
CMS2_k127_1828588_7 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000004404 188.0
CMS2_k127_1828588_8 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000000000000003004 187.0
CMS2_k127_1828588_9 CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000000002189 168.0
CMS2_k127_1870357_0 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000002471 124.0
CMS2_k127_1929836_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 345.0
CMS2_k127_1929836_1 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 327.0
CMS2_k127_1929836_2 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003173 271.0
CMS2_k127_1929836_3 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000008958 242.0
CMS2_k127_1929836_4 Permease - - - 0.00000000000000000000000000000000000000000000000000000000129 216.0
CMS2_k127_1929836_5 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00003241 48.0
CMS2_k127_198597_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 499.0
CMS2_k127_198597_1 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000000000000002277 221.0
CMS2_k127_198597_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000007627 199.0
CMS2_k127_198597_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000006406 138.0
CMS2_k127_198597_4 protein conserved in archaea - - - 0.0000000000000000000000000004007 119.0
CMS2_k127_198597_5 Virulence factor BrkB K07058 - - 0.000000000000000002482 96.0
CMS2_k127_198597_6 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000003128 61.0
CMS2_k127_198597_7 Protein of unknown function (DUF1699) - - - 0.0003561 48.0
CMS2_k127_1988517_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006639 509.0
CMS2_k127_1988517_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 GO:0002097,GO:0002101,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 430.0
CMS2_k127_1988517_10 Psort location Cytoplasmic, score 9.98 - - - 0.00000000000000000001939 96.0
CMS2_k127_1988517_2 domain protein K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 295.0
CMS2_k127_1988517_3 HTH-type transcriptional regulatory protein K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 293.0
CMS2_k127_1988517_4 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001994 277.0
CMS2_k127_1988517_5 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000008631 235.0
CMS2_k127_1988517_6 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000003377 223.0
CMS2_k127_1988517_7 pfam ammecr1 K09141 - - 0.000000000000000000000000000000000000000000000000000000000001027 217.0
CMS2_k127_1988517_8 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000004303 184.0
CMS2_k127_1988517_9 beta-lactamase domain protein - - - 0.00000000000000000000000003401 113.0
CMS2_k127_2042493_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 546.0
CMS2_k127_2042493_1 - - - - 0.00000000000000002037 86.0
CMS2_k127_2054418_0 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000002365 143.0
CMS2_k127_2054418_1 Bacterial SH3 domain homologues - - - 0.00000000000000001328 98.0
CMS2_k127_2054418_2 Thiamine-binding protein - - - 0.000000002025 60.0
CMS2_k127_2058546_0 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 7.918e-259 807.0
CMS2_k127_2058546_1 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 518.0
CMS2_k127_2058546_2 PFAM Methyl-coenzyme M reductase gamma subunit K00402 - 2.8.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 351.0
CMS2_k127_2058546_3 Methyl-coenzyme M reductase operon protein D K03422 - - 0.000000000000000000000000000000000001846 143.0
CMS2_k127_2058546_4 PFAM Radical SAM domain protein K06871 - - 0.000000000000001708 76.0
CMS2_k127_2059625_0 PFAM Cache, type 2 domain protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002406 267.0
CMS2_k127_2059625_1 Fumarylacetoacetate (FAA) hydrolase family K02554 - 4.2.1.80 0.0000000000000000000000000000000000000000000000000000000000000001436 229.0
CMS2_k127_2059625_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000002857 205.0
CMS2_k127_2059625_3 PFAM nuclease (SNase domain protein) - - - 0.000006925 54.0
CMS2_k127_2063813_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.493e-294 923.0
CMS2_k127_2063813_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 3.096e-283 882.0
CMS2_k127_2063813_10 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000008425 194.0
CMS2_k127_2063813_11 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000000001858 188.0
CMS2_k127_2063813_12 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00578 - 2.1.1.86 0.000000000000000005032 87.0
CMS2_k127_2063813_13 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00583 - 2.1.1.86 0.000000000000001569 78.0
CMS2_k127_2063813_14 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00582 - 2.1.1.86 0.00000000001179 68.0
CMS2_k127_2063813_2 PFAM Thiolase K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 557.0
CMS2_k127_2063813_3 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 499.0
CMS2_k127_2063813_4 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 405.0
CMS2_k127_2063813_5 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 367.0
CMS2_k127_2063813_6 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00580 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004565 275.0
CMS2_k127_2063813_7 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000001133 269.0
CMS2_k127_2063813_8 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001909 254.0
CMS2_k127_2063813_9 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00579 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000003096 243.0
CMS2_k127_207610_0 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 534.0
CMS2_k127_207610_1 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000005065 162.0
CMS2_k127_207610_2 Periplasmic copper-binding protein (NosD) K01179 - 3.2.1.4 0.000000000000000000000007523 115.0
CMS2_k127_207610_3 - K06317 - - 0.00000009573 56.0
CMS2_k127_207610_4 membrane - - - 0.00001476 48.0
CMS2_k127_2076435_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 2.414e-309 961.0
CMS2_k127_2076435_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 402.0
CMS2_k127_2076435_2 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004658 399.0
CMS2_k127_2076435_3 Permease family K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 354.0
CMS2_k127_2076435_4 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000004045 244.0
CMS2_k127_209619_0 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000001256 99.0
CMS2_k127_209619_1 Tetratricopeptide repeat - - - 0.00000000000002561 84.0
CMS2_k127_2097810_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 441.0
CMS2_k127_2097810_1 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000007707 111.0
CMS2_k127_2097810_2 heterodisulfide reductase K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000001734 65.0
CMS2_k127_2097810_3 Heterodisulfide reductase subunit A and related polyferredoxins K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0001477 46.0
CMS2_k127_2103328_0 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007986 584.0
CMS2_k127_2103328_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 523.0
CMS2_k127_2103328_2 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000252 167.0
CMS2_k127_2120646_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 479.0
CMS2_k127_2121057_0 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 5.752e-260 818.0
CMS2_k127_2121057_1 oligoendopeptidase F K08602 - - 3.296e-209 665.0
CMS2_k127_2121057_2 Uncharacterized conserved protein (DUF2278) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 368.0
CMS2_k127_2121057_3 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 299.0
CMS2_k127_2121057_4 oligoendopeptidase F K08602 - - 0.000000000000000006816 88.0
CMS2_k127_2139359_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000773 488.0
CMS2_k127_2139359_1 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 367.0
CMS2_k127_2139359_2 COG1226 Kef-type K transport systems K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 294.0
CMS2_k127_2139359_3 - - - - 0.0000000000000000000000000000000000000000467 154.0
CMS2_k127_2139359_4 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000003157 80.0
CMS2_k127_2149403_0 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 474.0
CMS2_k127_2149403_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 374.0
CMS2_k127_2149403_2 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 365.0
CMS2_k127_2149403_3 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 358.0
CMS2_k127_2149403_4 Putative Fe-S cluster K11260 - - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
CMS2_k127_2149403_5 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.000000000000000000001492 98.0
CMS2_k127_2149403_6 Belongs to the SUI1 family K03113 - - 0.00000005894 54.0
CMS2_k127_2173088_0 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 289.0
CMS2_k127_2173088_1 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000000009872 155.0
CMS2_k127_2173088_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000489 56.0
CMS2_k127_2182001_0 Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 389.0
CMS2_k127_2182001_1 ATPases associated with a variety of cellular activities K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 289.0
CMS2_k127_2182001_10 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000006242 146.0
CMS2_k127_2182001_11 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000001967 123.0
CMS2_k127_2182001_12 extracellular matrix structural constituent - - - 0.0000000000000001199 92.0
CMS2_k127_2182001_13 Transcriptional activator domain - - - 0.00000000006788 66.0
CMS2_k127_2182001_2 Pterin binding enzyme K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 294.0
CMS2_k127_2182001_3 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004764 291.0
CMS2_k127_2182001_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000201 263.0
CMS2_k127_2182001_5 ABC-3 protein K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000284 264.0
CMS2_k127_2182001_6 transferase hexapeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006514 246.0
CMS2_k127_2182001_7 Zinc-uptake complex component A periplasmic K02077,K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000000006301 244.0
CMS2_k127_2182001_8 domain protein K01992,K06994 - - 0.00000000000000000000000000000000000000000000000000000000143 209.0
CMS2_k127_2182001_9 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000006725 167.0
CMS2_k127_2182537_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 323.0
CMS2_k127_2182537_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 311.0
CMS2_k127_2182537_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006893 283.0
CMS2_k127_2182537_3 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000000000000181 248.0
CMS2_k127_2182537_4 Rhodanese Homology Domain - - - 0.00000000000000000000000000003715 119.0
CMS2_k127_2182537_5 Right handed beta helix region - - - 0.0000000000006518 79.0
CMS2_k127_2195050_0 aconitate hydratase K01681 - 4.2.1.3 5.027e-263 826.0
CMS2_k127_2195050_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 576.0
CMS2_k127_2195050_2 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 471.0
CMS2_k127_2195050_3 - - - - 0.000000002602 65.0
CMS2_k127_220481_0 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 320.0
CMS2_k127_220481_1 PFAM DNA polymerase, beta domain protein region K07075 - - 0.0000000000000000000000000000000007499 132.0
CMS2_k127_220481_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000002203 130.0
CMS2_k127_220481_3 - - - - 0.00000000000003762 77.0
CMS2_k127_220481_4 periplasmic K07218 - - 0.00000000001187 74.0
CMS2_k127_220481_5 Protein of unknown function DUF86 - - - 0.0000000003311 63.0
CMS2_k127_220481_6 Protein of unknown function DUF86 - - - 0.000000002081 59.0
CMS2_k127_220481_7 - - - - 0.00000003771 58.0
CMS2_k127_2215585_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 550.0
CMS2_k127_2215585_1 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 379.0
CMS2_k127_2215585_2 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 346.0
CMS2_k127_2215585_3 Cobalt transport protein K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000001657 230.0
CMS2_k127_2215585_4 PDGLE domain K02007,K02009 - - 0.000000000000000000000000000000000000007477 147.0
CMS2_k127_2223349_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 347.0
CMS2_k127_2223349_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000002007 250.0
CMS2_k127_2223349_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000211 112.0
CMS2_k127_223237_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 354.0
CMS2_k127_223237_1 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 309.0
CMS2_k127_223237_10 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000008287 57.0
CMS2_k127_223237_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 299.0
CMS2_k127_223237_3 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000004218 239.0
CMS2_k127_223237_4 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000006296 218.0
CMS2_k127_223237_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000003651 181.0
CMS2_k127_223237_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000004135 169.0
CMS2_k127_223237_7 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000000000000001443 149.0
CMS2_k127_223237_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000274 96.0
CMS2_k127_223237_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000002551 85.0
CMS2_k127_223530_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 2.449e-198 634.0
CMS2_k127_223530_1 PFAM TrkA-C domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 444.0
CMS2_k127_223530_10 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000000000001295 123.0
CMS2_k127_223530_11 binds to the 23S rRNA K02922 - - 0.000000000000000001245 86.0
CMS2_k127_223530_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000008718 71.0
CMS2_k127_223530_13 - - - - 0.00001088 57.0
CMS2_k127_223530_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 425.0
CMS2_k127_223530_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 385.0
CMS2_k127_223530_4 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000009521 222.0
CMS2_k127_223530_5 Predicted transporter (DUF2162) - - - 0.00000000000000000000000000000000000000000000344 171.0
CMS2_k127_223530_6 Stage II sporulation protein M - - - 0.00000000000000000000000000000000000000003698 163.0
CMS2_k127_223530_7 Uncharacterized conserved protein (DUF2149) - - - 0.00000000000000000000000000000000000000546 150.0
CMS2_k127_223530_8 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000103 147.0
CMS2_k127_223530_9 MotA/TolQ/ExbB proton channel family - - - 0.0000000000000000000000000000000000001479 158.0
CMS2_k127_2247159_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1517.0
CMS2_k127_228031_0 Histone deacetylase domain - - - 7.207e-211 666.0
CMS2_k127_228031_1 Hydantoinase/oxoprolinase N-terminal region - - - 7.007e-197 630.0
CMS2_k127_228031_2 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000004567 150.0
CMS2_k127_2282558_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 2.872e-292 906.0
CMS2_k127_2282558_1 Molybdopterin oxidoreductase K00201 - 1.2.7.12 1.43e-222 702.0
CMS2_k127_2282558_10 Putative Fe-S cluster - - - 0.000000000003531 72.0
CMS2_k127_2282558_2 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 473.0
CMS2_k127_2282558_3 4Fe-4S double cluster binding domain K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 441.0
CMS2_k127_2282558_4 GXGXG motif K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 290.0
CMS2_k127_2282558_5 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005086 247.0
CMS2_k127_2282558_6 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000269 224.0
CMS2_k127_2282558_7 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000108 216.0
CMS2_k127_2282558_8 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.00000000000000000000000000000000000000000000003309 173.0
CMS2_k127_2282558_9 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000005951 145.0
CMS2_k127_2284088_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 348.0
CMS2_k127_2284088_1 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003707 282.0
CMS2_k127_2284088_2 Rhodanese Homology Domain - - - 0.000000002478 65.0
CMS2_k127_2284088_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0001109 46.0
CMS2_k127_2292819_0 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 324.0
CMS2_k127_2292819_1 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000000002389 162.0
CMS2_k127_2292819_2 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000001729 155.0
CMS2_k127_2292865_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.157e-199 634.0
CMS2_k127_2292865_1 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008997 280.0
CMS2_k127_2292865_2 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004066 262.0
CMS2_k127_2292865_3 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001181 243.0
CMS2_k127_2292865_4 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000002451 188.0
CMS2_k127_2292865_5 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000002239 180.0
CMS2_k127_2292865_6 Rhomboid family K07059 - - 0.000000000000000000000000000000000006855 145.0
CMS2_k127_2292865_7 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000003869 78.0
CMS2_k127_2293754_0 Molybdate transporter of MFS superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 346.0
CMS2_k127_2293754_1 Cellulose biosynthesis protein BcsQ K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001594 260.0
CMS2_k127_2293754_2 Domain of unknown function (DUF4198) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000085 255.0
CMS2_k127_2293754_3 AAA domain K02013 - 3.6.3.34 0.00000000000000000005627 91.0
CMS2_k127_2293754_4 - K02016 - - 0.000000000000003635 83.0
CMS2_k127_2293754_5 Predicted RNA-binding protein - - - 0.000000007412 60.0
CMS2_k127_2293754_6 Peptidase C26 - - - 0.00004872 46.0
CMS2_k127_2293754_7 PKD domain - - - 0.00007068 55.0
CMS2_k127_231174_0 snf2 family K08282 - 2.7.11.1 3.885e-290 925.0
CMS2_k127_231174_1 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 419.0
CMS2_k127_231174_10 OsmC-like protein - - - 0.0002794 47.0
CMS2_k127_231174_11 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0004845 52.0
CMS2_k127_231174_2 SWIM zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008218 273.0
CMS2_k127_231174_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000001554 211.0
CMS2_k127_231174_4 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000000000000003899 155.0
CMS2_k127_231174_5 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000002684 116.0
CMS2_k127_231174_6 NHL repeat - - - 0.0000000000000003893 84.0
CMS2_k127_231174_7 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000308 77.0
CMS2_k127_231174_8 nucleic acid binding OB-fold tRNA helicase-type - - - 0.00000000207 63.0
CMS2_k127_231174_9 F420H2 dehydrogenase subunit FpoO K22170 - 1.5.98.3 0.00000002203 57.0
CMS2_k127_2317181_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 479.0
CMS2_k127_2317181_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 314.0
CMS2_k127_2317181_10 Tetratricopeptide repeat - - - 0.000000000000008024 80.0
CMS2_k127_2317181_2 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000000000000000000004304 266.0
CMS2_k127_2317181_3 Gas vesicle synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000004843 228.0
CMS2_k127_2317181_5 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000000000000000000007663 151.0
CMS2_k127_2317181_6 - - - - 0.000000000000000000000000000000000000002141 154.0
CMS2_k127_2317181_7 Helix-turn-helix domain protein K03627 - - 0.0000000000000000000000000000000000000249 148.0
CMS2_k127_2317181_8 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.000000000000000000000000000000004132 136.0
CMS2_k127_2317181_9 Gas vesicle protein K - - - 0.000000000000000000000111 100.0
CMS2_k127_2324132_0 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 306.0
CMS2_k127_2324132_1 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 289.0
CMS2_k127_2324132_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002686 244.0
CMS2_k127_2324132_3 TIGRFAM DJ-1 family protein K03152 - 3.5.1.124 0.000000000000000000000000002316 115.0
CMS2_k127_2340633_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 552.0
CMS2_k127_2340633_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 404.0
CMS2_k127_2340633_2 protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain - - - 0.0000000000000000000000000000000000000000000001031 183.0
CMS2_k127_2340633_3 nitroreductase K04719 - 1.13.11.79 0.00000000000000000000000000000000000000002009 160.0
CMS2_k127_2360229_0 PFAM SufBD protein K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 419.0
CMS2_k127_2360229_1 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 288.0
CMS2_k127_2360229_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000000007109 165.0
CMS2_k127_2360229_3 metal ion binding - - - 0.000000000000000001534 92.0
CMS2_k127_2360229_4 Belongs to the UPF0235 family K09131 - - 0.000000000000000004569 89.0
CMS2_k127_237088_0 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 5.963e-198 621.0
CMS2_k127_237088_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000003132 235.0
CMS2_k127_2375187_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.293e-201 636.0
CMS2_k127_2375187_1 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 395.0
CMS2_k127_2375187_2 Methanogenesis marker protein 8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 351.0
CMS2_k127_2375187_3 Flavoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002763 263.0
CMS2_k127_2375187_4 Functions in trans to edit the amino acid moiety from K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000003225 256.0
CMS2_k127_2375187_5 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000000000000000000000000000005991 216.0
CMS2_k127_2375187_6 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.0000000000000000000000000000000000000000000000002122 188.0
CMS2_k127_2375187_7 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000127 136.0
CMS2_k127_2375187_8 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000002181 121.0
CMS2_k127_2375187_9 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000003721 106.0
CMS2_k127_238357_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.08e-235 745.0
CMS2_k127_238357_1 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 372.0
CMS2_k127_238357_10 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000005576 85.0
CMS2_k127_238357_11 Tetratricopeptide repeat - - - 0.00000000005376 72.0
CMS2_k127_238357_12 Dihydrodipicolinate reductase, N-terminus K00150 - 1.2.1.59 0.0000001864 63.0
CMS2_k127_238357_13 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00003872 46.0
CMS2_k127_238357_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003442 266.0
CMS2_k127_238357_3 Adenylylsulphate kinase K00860 - 2.7.1.25 0.00000000000000000000000000000000000000000000000000000000002687 211.0
CMS2_k127_238357_4 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000002011 173.0
CMS2_k127_238357_5 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000009563 163.0
CMS2_k127_238357_6 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000645 162.0
CMS2_k127_238357_7 Non-histone chromosomal protein MC1 - - - 0.000000000000000000000000000000555 124.0
CMS2_k127_238357_8 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000000000001717 118.0
CMS2_k127_238357_9 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000000001135 88.0
CMS2_k127_2383947_0 PFAM Gas vesicle synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001058 254.0
CMS2_k127_2383947_1 PFAM Gas vesicle synthesis - - - 0.000000000000001474 80.0
CMS2_k127_2383947_2 - - - - 0.000000000000002502 78.0
CMS2_k127_24001_0 Glycogen synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 539.0
CMS2_k127_24001_1 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000001832 56.0
CMS2_k127_2416_0 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 404.0
CMS2_k127_2416_1 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 314.0
CMS2_k127_2416_2 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000003109 153.0
CMS2_k127_2416_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.0000000000000000000000000000000002999 137.0
CMS2_k127_2416_4 Protein of unknown function (DUF1638) - - - 0.00000000000000000000002036 109.0
CMS2_k127_2416_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00005441 46.0
CMS2_k127_2458057_0 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 448.0
CMS2_k127_2458057_1 PFAM cobalamin synthesis protein P47K - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 391.0
CMS2_k127_2458057_2 PFAM ABC transporter related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 374.0
CMS2_k127_2458057_3 PFAM Fe-S cluster domain protein K06939 - - 0.000000000000000000000002249 112.0
CMS2_k127_2458057_4 Domain of unknown function (DUF4440) - - - 0.0000000000000000000003506 101.0
CMS2_k127_2458057_5 Protein of unknown function DUF86 - - - 0.000000007235 59.0
CMS2_k127_2458057_6 DNA polymerase beta domain protein region K07075 - - 0.0000006117 58.0
CMS2_k127_2470123_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 527.0
CMS2_k127_2470123_1 E1-E2 ATPase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 312.0
CMS2_k127_2470123_2 YHS domain - - - 0.00000000000000001867 84.0
CMS2_k127_2473782_0 Cleaves the N-terminal amino acid of tripeptides K01270 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 313.0
CMS2_k127_2473782_1 Domain of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000001859 224.0
CMS2_k127_2473782_2 Type I restriction enzyme R protein N terminus (HSDR_N) K07504 - - 0.00000000000000000000000000000000205 131.0
CMS2_k127_2487235_0 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 290.0
CMS2_k127_2487235_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000146 177.0
CMS2_k127_2487235_2 membrane - - - 0.000000000000000000000000000002256 130.0
CMS2_k127_2487235_3 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000194 46.0
CMS2_k127_2498367_0 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 534.0
CMS2_k127_2498367_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000008091 119.0
CMS2_k127_25464_0 PFAM peptidase M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 327.0
CMS2_k127_25464_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.000000000000000000000000000000000000000000000001403 182.0
CMS2_k127_25464_2 PFAM peptidase - - - 0.000000000000000000000000000000000000009896 150.0
CMS2_k127_2548007_0 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001946 284.0
CMS2_k127_2548007_1 Diphthamide synthase - - - 0.0000000000000000000000000000000000000000000000000000000299 202.0
CMS2_k127_2548007_2 - - - - 0.00000000000006975 78.0
CMS2_k127_2548007_3 polysaccharide biosynthetic process - - - 0.0004837 51.0
CMS2_k127_2587515_0 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 417.0
CMS2_k127_2587515_1 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 349.0
CMS2_k127_2587515_2 - K02016 - - 0.000000000000000000000000667 112.0
CMS2_k127_2587515_3 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000004722 51.0
CMS2_k127_2600595_0 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004201 288.0
CMS2_k127_2600595_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000001053 198.0
CMS2_k127_2600595_2 SpoVT / AbrB like domain - - - 0.0000000000000000000000007042 107.0
CMS2_k127_2600595_3 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000003921 63.0
CMS2_k127_2600595_4 - - - - 0.000000001653 64.0
CMS2_k127_2605906_0 PFAM ferredoxin-dependent glutamate synthase - - - 1.953e-285 881.0
CMS2_k127_2605906_1 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 392.0
CMS2_k127_2605906_2 NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit K00335,K18331 - 1.12.1.3,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 352.0
CMS2_k127_2605906_3 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07005 - - 0.00000000000000000000000000000000000000000000000000000000000001949 218.0
CMS2_k127_2605906_4 - - - - 0.0000000000000000000000000000000000000000000000000000000009846 214.0
CMS2_k127_2605906_5 cobalt chelatase K02190 - 4.99.1.3 0.0000000000000000000000000000000000000000000000000000291 198.0
CMS2_k127_2605906_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000008689 164.0
CMS2_k127_2605906_7 - - - - 0.000000000000000006221 91.0
CMS2_k127_2611361_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 381.0
CMS2_k127_2611361_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008608 267.0
CMS2_k127_2611361_2 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000002704 156.0
CMS2_k127_2611361_3 - - - - 0.000000000000000000000000000000009162 133.0
CMS2_k127_2611361_4 Nucleotidyltransferase domain K07075 - - 0.0001352 52.0
CMS2_k127_2612212_0 Belongs to the helicase family. UvrD subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 561.0
CMS2_k127_2612212_1 PD-(D/E)XK nuclease superfamily - - - 0.000009376 56.0
CMS2_k127_2624411_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009551 398.0
CMS2_k127_2624411_1 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 339.0
CMS2_k127_2624411_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000004422 228.0
CMS2_k127_2624411_3 Putative RNA methyltransferase K09142 - - 0.0000000000000000000000000000000003263 138.0
CMS2_k127_2624411_4 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002168 81.0
CMS2_k127_2643193_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 5.413e-194 618.0
CMS2_k127_2643193_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 327.0
CMS2_k127_2643193_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 297.0
CMS2_k127_2643193_3 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000001787 207.0
CMS2_k127_2643193_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000145 186.0
CMS2_k127_2651462_0 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 346.0
CMS2_k127_2651462_1 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 291.0
CMS2_k127_2651462_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000126 254.0
CMS2_k127_2651621_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.000000000000000000000008633 101.0
CMS2_k127_2651621_1 Protein of unknown function DUF86 - - - 0.0000000000000000002199 95.0
CMS2_k127_2651621_2 Nucleotidyltransferase domain K07076 - - 0.0000001138 59.0
CMS2_k127_2651621_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K02574 - - 0.00003926 48.0
CMS2_k127_2651621_4 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.0004082 44.0
CMS2_k127_2653218_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 326.0
CMS2_k127_2653218_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000006665 257.0
CMS2_k127_2666963_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 332.0
CMS2_k127_2666963_1 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000007794 241.0
CMS2_k127_2666963_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000001714 130.0
CMS2_k127_2666963_3 Stage II sporulation protein M K06384 - - 0.000000000000000000523 94.0
CMS2_k127_2666963_4 UbiA prenyltransferase family K20616 - - 0.00000000000127 79.0
CMS2_k127_2706200_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1140.0
CMS2_k127_2741321_0 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 334.0
CMS2_k127_2741321_1 Voltage gated chloride channel K03281 - - 0.000000000008134 70.0
CMS2_k127_2741321_2 conserved repeat domain - - - 0.000001241 60.0
CMS2_k127_2744509_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 8.067e-211 661.0
CMS2_k127_2744509_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 284.0
CMS2_k127_2744509_2 alpha-galactosidase K07407 - 3.2.1.22 0.000008462 57.0
CMS2_k127_2749619_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 412.0
CMS2_k127_2749619_1 PFAM Alkaline phosphatase K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005118 282.0
CMS2_k127_2749619_2 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000004004 199.0
CMS2_k127_2749619_3 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000005217 185.0
CMS2_k127_2749619_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.0000000000000002777 80.0
CMS2_k127_2749619_5 Lrp/AsnC ligand binding domain - - - 0.0000000000023 71.0
CMS2_k127_2749619_6 PBP superfamily domain K02040 - - 0.000000001409 60.0
CMS2_k127_2749678_0 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 461.0
CMS2_k127_2749678_1 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 409.0
CMS2_k127_2749678_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 391.0
CMS2_k127_2749678_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 379.0
CMS2_k127_2749678_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001578 278.0
CMS2_k127_2749678_5 Belongs to the UPF0216 family K09737 - - 0.000000000000000000008822 97.0
CMS2_k127_2749678_6 Belongs to the eukaryotic ribosomal protein eS17 family K02962 - - 0.0000000000001162 72.0
CMS2_k127_2749678_7 - - - - 0.0000000000001665 77.0
CMS2_k127_2749678_8 Nitrate reductase gamma subunit K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000002733 67.0
CMS2_k127_2752933_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2.204e-237 747.0
CMS2_k127_2752933_1 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 459.0
CMS2_k127_2752933_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000005178 213.0
CMS2_k127_2752933_3 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001444 173.0
CMS2_k127_2752933_4 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000000000006603 122.0
CMS2_k127_2752933_5 binds to the 23S rRNA K02896 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.00000000000000000001906 91.0
CMS2_k127_2752933_6 - - - - 0.000005176 57.0
CMS2_k127_2753961_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 1.209e-228 717.0
CMS2_k127_2753961_1 domain, Protein - - - 0.0000002078 56.0
CMS2_k127_278341_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 500.0
CMS2_k127_278341_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 321.0
CMS2_k127_278341_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 309.0
CMS2_k127_278341_3 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 291.0
CMS2_k127_278341_4 sugar fermentation stimulation protein K06206 - - 0.000000000000000000000000000000000000000000000000000001939 200.0
CMS2_k127_278341_5 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.0000000000000000000000000002043 121.0
CMS2_k127_278341_6 AIR carboxylase K06898 - - 0.000000000000000000000009713 101.0
CMS2_k127_278341_7 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000105 82.0
CMS2_k127_278341_8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000002918 70.0
CMS2_k127_278504_0 PFAM glutamate synthase alpha subunit K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000007162 256.0
CMS2_k127_278504_1 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000006202 110.0
CMS2_k127_278504_2 Transposase IS66 family - - - 0.0000000000000000000000008925 108.0
CMS2_k127_279526_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 362.0
CMS2_k127_279526_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 368.0
CMS2_k127_279526_2 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 312.0
CMS2_k127_279526_3 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003039 269.0
CMS2_k127_279526_4 - - - - 0.00000000000000000000000000000000000000000000000000000000001386 222.0
CMS2_k127_279526_5 - - - - 0.0008175 45.0
CMS2_k127_2815211_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 303.0
CMS2_k127_2815211_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000886 264.0
CMS2_k127_2829218_0 - - - - 0.000000000000000000000000000000003705 131.0
CMS2_k127_2829218_1 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000008708 116.0
CMS2_k127_2829218_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.00000000000000000000001102 106.0
CMS2_k127_2829218_3 PFAM sigma-70 region 4 domain protein K09714 - - 0.000000000000000000006134 96.0
CMS2_k127_2832732_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 298.0
CMS2_k127_2832732_1 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000004143 162.0
CMS2_k127_2832732_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000001045 81.0
CMS2_k127_2851404_0 - - - - 0.00000000000000000000000000000009188 129.0
CMS2_k127_2851404_1 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.00000000000000000001072 94.0
CMS2_k127_2851404_2 PFAM Thioredoxin K03671 - - 0.00000000000006101 76.0
CMS2_k127_2870203_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008951 436.0
CMS2_k127_2870203_1 Domain of unknown function (DUF1743) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 323.0
CMS2_k127_2870203_2 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000000001118 149.0
CMS2_k127_288640_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 608.0
CMS2_k127_288640_1 Mn2 dependent serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 433.0
CMS2_k127_288640_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 288.0
CMS2_k127_288640_3 RNA methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004991 282.0
CMS2_k127_288640_4 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001549 258.0
CMS2_k127_288640_5 Propeptide_C25 - - - 0.00000000000000000000000000000000000000000000000000000000000005056 241.0
CMS2_k127_288640_6 serine-type aminopeptidase activity K02030,K14475 - - 0.0000000000000000008084 95.0
CMS2_k127_288640_7 PFAM carbonic anhydrase - - - 0.00000000108 72.0
CMS2_k127_2904369_0 CobN/Magnesium Chelatase K02230 - 6.6.1.2 0.0 1381.0
CMS2_k127_2904369_1 PFAM periplasmic binding protein K02016 - - 0.00000000003237 64.0
CMS2_k127_2930366_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 511.0
CMS2_k127_2930366_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009098 316.0
CMS2_k127_2930366_2 TIGRFAM archaeoflavoprotein AfpA - - - 0.000000000000000000000000000000000000000000000000000000000000002047 221.0
CMS2_k127_2930366_3 Protein of unknown function (DUF1211) - - - 0.00000000000000000000001696 105.0
CMS2_k127_293428_0 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 341.0
CMS2_k127_293428_1 GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 310.0
CMS2_k127_293428_2 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000001187 130.0
CMS2_k127_293428_3 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000001569 130.0
CMS2_k127_293428_4 Zn-ribbon containing protein K07163 - - 0.000000000000000000004234 100.0
CMS2_k127_293428_5 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000002158 83.0
CMS2_k127_293428_6 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000009301 63.0
CMS2_k127_293428_7 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000003318 73.0
CMS2_k127_293428_8 Mo-molybdopterin cofactor metabolic process - - - 0.00002354 48.0
CMS2_k127_2950645_0 Psort location CytoplasmicMembrane, score 10.00 K03458 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 543.0
CMS2_k127_2950645_1 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 522.0
CMS2_k127_2950645_2 STAS domain K04749 - - 0.000000000000000000000000000000000531 133.0
CMS2_k127_2950645_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.0000000000000000000000000003263 119.0
CMS2_k127_2950645_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.00000000000000000758 87.0
CMS2_k127_2986788_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 570.0
CMS2_k127_2986788_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 322.0
CMS2_k127_2991645_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 3.125e-201 636.0
CMS2_k127_2991645_1 DNA polymerase beta domain protein region K07075 - - 0.00000000000001465 78.0
CMS2_k127_2992669_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 2.474e-311 964.0
CMS2_k127_2992669_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 538.0
CMS2_k127_2992669_2 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000000000000004676 199.0
CMS2_k127_2992669_3 Hsp20/alpha crystallin family K13993 - - 0.0000000000000001747 85.0
CMS2_k127_3019634_0 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000005394 205.0
CMS2_k127_3019634_1 Helix-hairpin-helix motif - - - 0.00000000000000000000000000000000002521 140.0
CMS2_k127_3019634_2 Domain of unknown function (DUF4130 - - - 0.000004075 57.0
CMS2_k127_3075346_0 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 385.0
CMS2_k127_3075346_1 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008641 256.0
CMS2_k127_3075346_2 - - - - 0.000000000000000000000000002273 115.0
CMS2_k127_3075346_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000005808 115.0
CMS2_k127_3075346_4 Transcriptional regulator K07729 - - 0.00000000000000000000000009493 107.0
CMS2_k127_3075346_5 - - - - 0.0000000000000000001185 93.0
CMS2_k127_3085120_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 428.0
CMS2_k127_3085120_1 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 376.0
CMS2_k127_3085120_2 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000222 262.0
CMS2_k127_3085120_3 - - - - 0.000000000001505 78.0
CMS2_k127_3116308_0 lyase activity - - - 0.0000000000000000000000000000000000001617 161.0
CMS2_k127_3116308_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.00000000000000000007613 97.0
CMS2_k127_3116308_2 - - - - 0.0000000000005241 78.0
CMS2_k127_3124993_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 408.0
CMS2_k127_3124993_1 site-specific DNA-methyltransferase (adenine-specific) activity K03427 - 2.1.1.72 0.0006171 45.0
CMS2_k127_3139433_0 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 348.0
CMS2_k127_3139433_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K22161 - 1.5.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009898 295.0
CMS2_k127_3139433_2 4Fe-4S dicluster domain K22164 - 1.5.98.3 0.000000000000000000000000008354 116.0
CMS2_k127_3139433_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K22166 - 1.5.98.3 0.000000000000002824 77.0
CMS2_k127_3139433_4 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K22165 - 1.5.98.3 0.000000000002747 70.0
CMS2_k127_3139433_5 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000355 46.0
CMS2_k127_3139790_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 598.0
CMS2_k127_3139790_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000003738 233.0
CMS2_k127_3139790_2 Mn2 dependent serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000003117 168.0
CMS2_k127_3141249_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.03e-227 718.0
CMS2_k127_3141249_1 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000005192 250.0
CMS2_k127_3141249_2 COG0170 Dolichol kinase - - - 0.00000000000000000002308 99.0
CMS2_k127_3141249_3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000007884 68.0
CMS2_k127_3150557_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 612.0
CMS2_k127_3150557_1 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000003788 183.0
CMS2_k127_3150557_2 Transglutaminase-like superfamily - - - 0.000000000000352 82.0
CMS2_k127_3154709_0 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 2.035e-203 639.0
CMS2_k127_3154709_1 PFAM magnesium chelatase ChlI subunit K03404,K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 409.0
CMS2_k127_3154709_2 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 311.0
CMS2_k127_3154709_3 AAA domain (dynein-related subfamily) K03404,K03405 - 6.6.1.1 0.000000000000000000000000000000000000001027 163.0
CMS2_k127_3154709_4 Pyridoxal-dependent decarboxylase, C-terminal sheet domain K13747 - 4.1.1.96 0.0000000000000000000000000000000000037 139.0
CMS2_k127_3156908_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 577.0
CMS2_k127_3156908_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 542.0
CMS2_k127_3156908_10 - - - - 0.00000000000000002037 86.0
CMS2_k127_3156908_11 B-block binding subunit of TFIIIC - - - 0.000003781 49.0
CMS2_k127_3156908_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl- CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 474.0
CMS2_k127_3156908_3 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001132 278.0
CMS2_k127_3156908_4 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000001952 225.0
CMS2_k127_3156908_5 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000001247 199.0
CMS2_k127_3156908_6 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.0000000000000000000000000000000000000000000000004415 182.0
CMS2_k127_3156908_7 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000007692 109.0
CMS2_k127_3156908_8 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000009101 102.0
CMS2_k127_3156908_9 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000001083 96.0
CMS2_k127_3161127_0 Catalase K03781 - 1.11.1.6 8.61e-210 666.0
CMS2_k127_3161127_1 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 306.0
CMS2_k127_3161127_2 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000001236 208.0
CMS2_k127_3161127_3 Ferrous iron transport protein B C terminus K04759 - - 0.00000000000000000000000000000000000000000001773 166.0
CMS2_k127_3161127_4 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000001242 113.0
CMS2_k127_3178247_0 Cation transporter/ATPase, N-terminus K01539 - 3.6.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 420.0
CMS2_k127_3178247_1 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 323.0
CMS2_k127_3178247_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 307.0
CMS2_k127_3178247_3 PFAM Appr-1-p processing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005434 245.0
CMS2_k127_3178247_4 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000208 246.0
CMS2_k127_3178247_5 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000002833 176.0
CMS2_k127_3178247_6 Universal stress protein family - - - 0.00000000000000000000000000000000008925 139.0
CMS2_k127_3200510_0 PFAM oxidoreductase nitrogenase, component 1 K02586 - 1.18.6.1 1.734e-281 871.0
CMS2_k127_3200510_1 PFAM oxidoreductase nitrogenase, component 1 K02591 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 481.0
CMS2_k127_3200510_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000000000000000000000000000000000001487 175.0
CMS2_k127_3200510_3 Belongs to the P(II) protein family K02590 - - 0.0000000000000000000000000000000000000000002818 160.0
CMS2_k127_3200510_4 Belongs to the P(II) protein family K02589 - - 0.000000000000000000000000000000000000000001239 163.0
CMS2_k127_3200510_5 Belongs to the NifD NifK NifE NifN family K02587 - - 0.00000000000000000000000000000003296 127.0
CMS2_k127_3236453_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1153.0
CMS2_k127_3236453_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 7.832e-243 777.0
CMS2_k127_3236453_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 608.0
CMS2_k127_3236453_3 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000001187 207.0
CMS2_k127_3236453_4 ribosomal protein S15 K02956 - - 0.000000000000000000000000000000000000000000000000003351 185.0
CMS2_k127_3236453_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000001356 164.0
CMS2_k127_3236453_6 4Fe-4S dicluster domain - - - 0.0000000000000000123 86.0
CMS2_k127_3236453_7 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000004556 71.0
CMS2_k127_3236453_8 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000007448 53.0
CMS2_k127_3236453_9 Flavodoxin-like fold - - - 0.0005787 45.0
CMS2_k127_3245696_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1034.0
CMS2_k127_3245696_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 431.0
CMS2_k127_3245696_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000398 284.0
CMS2_k127_3245696_3 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000002463 228.0
CMS2_k127_3245696_4 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000002736 209.0
CMS2_k127_3245696_5 Histidine biosynthesis bifunctional protein HisB K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000134 163.0
CMS2_k127_3245696_6 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000005238 145.0
CMS2_k127_3245696_7 PFAM PRC-barrel domain - - - 0.0000000000000006406 80.0
CMS2_k127_3245696_8 intermembrane phospholipid transfer K07323 - - 0.00000000000005772 85.0
CMS2_k127_3245696_9 domain, Protein - - - 0.0000002133 63.0
CMS2_k127_325804_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000001003 203.0
CMS2_k127_325804_1 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000002162 204.0
CMS2_k127_325804_2 Methanogenesis marker protein 8 - - - 0.0000000000000000006405 91.0
CMS2_k127_325804_3 - - - - 0.000000000000004942 77.0
CMS2_k127_32751_0 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 416.0
CMS2_k127_32751_1 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 309.0
CMS2_k127_32751_2 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000003336 173.0
CMS2_k127_3313810_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 490.0
CMS2_k127_3313810_1 Lysine-2,3-aminomutase K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 397.0
CMS2_k127_3313810_10 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000005459 123.0
CMS2_k127_3313810_11 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000000000002488 101.0
CMS2_k127_3313810_12 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000000004404 90.0
CMS2_k127_3313810_13 DGC domain protein - - - 0.00000000000005456 74.0
CMS2_k127_3313810_14 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000002506 64.0
CMS2_k127_3313810_15 Acetyltransferase (GNAT) domain - - - 0.00000001305 68.0
CMS2_k127_3313810_16 S-layer protein - - - 0.0003282 49.0
CMS2_k127_3313810_2 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 391.0
CMS2_k127_3313810_3 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000521 349.0
CMS2_k127_3313810_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004521 283.0
CMS2_k127_3313810_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002771 268.0
CMS2_k127_3313810_6 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000009427 247.0
CMS2_k127_3313810_7 ATP-grasp domain K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000009766 237.0
CMS2_k127_3313810_8 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.0000000000000000000000000000000000000000000000000000002947 212.0
CMS2_k127_3313810_9 HD superfamily hydrolase K06950 - - 0.0000000000000000000000000000000000000006344 155.0
CMS2_k127_3335843_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 528.0
CMS2_k127_3335843_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 287.0
CMS2_k127_3335843_2 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001773 287.0
CMS2_k127_3335843_3 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000002225 255.0
CMS2_k127_3335843_4 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000001385 231.0
CMS2_k127_3335843_5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000002501 185.0
CMS2_k127_3335843_6 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000001539 195.0
CMS2_k127_3335843_7 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000000000001366 136.0
CMS2_k127_3335843_8 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0000000000006958 75.0
CMS2_k127_3335843_9 PFAM copper amine oxidase domain protein - - - 0.000000004075 68.0
CMS2_k127_333842_0 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 434.0
CMS2_k127_333842_1 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.90 0.000000000000000000000000000000000000000000000000000000001764 210.0
CMS2_k127_333842_2 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000008776 162.0
CMS2_k127_333842_3 Alpha/beta hydrolase of unknown function (DUF1400) - - - 0.000000000000000000000000301 121.0
CMS2_k127_333842_4 NHL repeat - - - 0.00000000000000000000003486 117.0
CMS2_k127_333842_5 Alkaline phosphatase - - - 0.000000000000005477 88.0
CMS2_k127_333842_6 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000005019 72.0
CMS2_k127_333842_7 Lecithin:cholesterol acyltransferase - - - 0.0000000005568 73.0
CMS2_k127_3359100_0 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000000000000000000000000009224 209.0
CMS2_k127_3359100_1 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000001782 208.0
CMS2_k127_3359100_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000001143 183.0
CMS2_k127_3359100_3 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000165 146.0
CMS2_k127_3360940_0 Putative Fe-S cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 412.0
CMS2_k127_3360940_1 Permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008584 383.0
CMS2_k127_3360940_2 DsrE/DsrF-like family K07235 - - 0.00000000000000000000000000000000000000000000003767 173.0
CMS2_k127_3360940_3 protein involved in the oxidation of intracellular sulfur K07236 - - 0.00000000000000000000000000000000000000001413 158.0
CMS2_k127_3360940_4 Ferredoxin K05337 - - 0.00000000000000000004554 92.0
CMS2_k127_3360940_5 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000005552 83.0
CMS2_k127_3360940_6 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000000000006645 76.0
CMS2_k127_3360940_7 DsrH like protein K07237 - - 0.000000004561 58.0
CMS2_k127_3364988_0 Putative small multi-drug export protein - - - 0.00000000000000000000000000000000000000000000000000000001815 201.0
CMS2_k127_3364988_1 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000003117 179.0
CMS2_k127_3364988_2 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000003713 122.0
CMS2_k127_3364988_3 Lamin Tail Domain - - - 0.00000001658 59.0
CMS2_k127_339500_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 555.0
CMS2_k127_339500_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 368.0
CMS2_k127_339500_2 SIR2-like domain - - - 0.0000000000000000000000004908 107.0
CMS2_k127_339500_3 PFAM copper amine oxidase domain protein - - - 0.0000000000001949 75.0
CMS2_k127_339500_4 - - - - 0.0006047 49.0
CMS2_k127_3426150_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 1.955e-246 777.0
CMS2_k127_3426150_1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 411.0
CMS2_k127_3426150_2 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 314.0
CMS2_k127_3426150_3 Belongs to the HesB IscA family K13628 - - 0.0001163 49.0
CMS2_k127_3464627_0 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 606.0
CMS2_k127_3464627_1 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001018 249.0
CMS2_k127_3464627_2 stage II sporulation K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000001788 226.0
CMS2_k127_3464627_3 - - - - 0.0000000000000000000000000000000000000002332 154.0
CMS2_k127_3464627_4 response to heat - - - 0.000000000006262 66.0
CMS2_k127_3464627_5 - - - - 0.00000000005533 64.0
CMS2_k127_3464627_6 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00003292 49.0
CMS2_k127_3468611_0 VWA domain containing CoxE-like protein K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 602.0
CMS2_k127_3468611_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 457.0
CMS2_k127_3468611_2 Pfam Sulfatase K01130 - 3.1.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 363.0
CMS2_k127_3468611_3 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000003054 214.0
CMS2_k127_3478288_0 TGS domain protein K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 531.0
CMS2_k127_3478288_1 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 332.0
CMS2_k127_3478288_2 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000002023 246.0
CMS2_k127_3478288_3 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000908 180.0
CMS2_k127_3498446_0 Ferrous iron transport protein B C terminus K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 488.0
CMS2_k127_3503114_0 E1-E2 ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006909 571.0
CMS2_k127_3503114_1 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001148 284.0
CMS2_k127_3503114_2 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000000000000000000000000002078 230.0
CMS2_k127_3503114_3 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000001042 193.0
CMS2_k127_3503114_4 Glutaredoxin - - - 0.00000000000000000000000000000000002203 136.0
CMS2_k127_3503114_5 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000003295 102.0
CMS2_k127_3503639_0 DUF3160 - - - 3.858e-194 627.0
CMS2_k127_3503639_1 S-layer protein - - - 0.000000000000000000000000007379 119.0
CMS2_k127_3535005_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 582.0
CMS2_k127_3535005_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006625 524.0
CMS2_k127_3535005_10 PFAM Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000007601 109.0
CMS2_k127_3535005_11 - - - - 0.0000000000000000001546 95.0
CMS2_k127_3535005_12 - - - - 0.0000000000008281 70.0
CMS2_k127_3535005_2 C-terminal region of MMR_HSR1 domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 411.0
CMS2_k127_3535005_3 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 398.0
CMS2_k127_3535005_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 366.0
CMS2_k127_3535005_5 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000001656 236.0
CMS2_k127_3535005_6 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000002185 232.0
CMS2_k127_3535005_7 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000003402 226.0
CMS2_k127_3535005_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000004964 190.0
CMS2_k127_3535005_9 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000001497 163.0
CMS2_k127_3547733_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 591.0
CMS2_k127_3547733_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 469.0
CMS2_k127_3547733_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 343.0
CMS2_k127_3547733_4 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007258 314.0
CMS2_k127_3547733_5 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000009087 199.0
CMS2_k127_3547733_6 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000004978 135.0
CMS2_k127_3555126_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000000000000001431 173.0
CMS2_k127_3580848_0 Domain of unknown function (DUF362) K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 482.0
CMS2_k127_3580848_1 5'-nucleotidase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 353.0
CMS2_k127_3580848_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000003176 149.0
CMS2_k127_3580848_3 4Fe-4S dicluster domain K00196 - - 0.0000000000000000000000000000000001493 136.0
CMS2_k127_3580848_4 tail collar domain protein - - - 0.000000000000000000000000000000008239 132.0
CMS2_k127_3580848_5 Phage Tail Collar Domain - - - 0.000000007842 63.0
CMS2_k127_3599729_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 438.0
CMS2_k127_3599729_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009666 413.0
CMS2_k127_3599729_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000006157 202.0
CMS2_k127_3599729_3 STAS domain K04749 - - 0.0000000000000001049 82.0
CMS2_k127_3599729_4 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000006085 55.0
CMS2_k127_3601282_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 3.698e-206 649.0
CMS2_k127_3601282_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 376.0
CMS2_k127_3601282_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 312.0
CMS2_k127_3613458_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 582.0
CMS2_k127_3613458_1 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009795 321.0
CMS2_k127_3613458_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009824 287.0
CMS2_k127_3613458_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000009527 214.0
CMS2_k127_3613458_4 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000000000006132 161.0
CMS2_k127_3613458_5 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000005802 143.0
CMS2_k127_3613458_6 Lysine methyltransferase K02493 - 2.1.1.297 0.000000000003836 68.0
CMS2_k127_3613458_7 Gar1/Naf1 RNA binding region K07569 - - 0.00000000006944 66.0
CMS2_k127_3621751_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 5.36e-250 780.0
CMS2_k127_3621751_1 COG0500 SAM-dependent methyltransferases K17462 - - 0.0000000000000000000000000000000000000000000000000000000000000001175 229.0
CMS2_k127_3621751_2 PFAM thioesterase superfamily K02614 - - 0.000000000000000000000000000000001374 135.0
CMS2_k127_3621751_3 Domain of unknown function (DUF4870) K09940 - - 0.0000000000000000000000000008741 117.0
CMS2_k127_3621751_4 - - - - 0.0000000000000000004558 89.0
CMS2_k127_3664194_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 467.0
CMS2_k127_3664194_1 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 403.0
CMS2_k127_3664194_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 369.0
CMS2_k127_3664194_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001291 276.0
CMS2_k127_3664194_4 cytidyltransferase-related domain K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000000000000005263 230.0
CMS2_k127_3664194_5 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000005293 186.0
CMS2_k127_3664194_6 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000000000000000000003651 181.0
CMS2_k127_3664194_7 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.000000000000000000000000000000000001082 149.0
CMS2_k127_3664315_0 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 554.0
CMS2_k127_3664315_1 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 474.0
CMS2_k127_3664315_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000817 361.0
CMS2_k127_3664315_3 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 349.0
CMS2_k127_3672379_0 TIGRFAM parallel beta-helix repeat (two copies) K07218 - - 0.0000000000000007145 92.0
CMS2_k127_3672379_1 Purple acid Phosphatase, N-terminal domain - - - 0.00005078 56.0
CMS2_k127_3675105_0 Cation transporter/ATPase, N-terminus K01539 - 3.6.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 422.0
CMS2_k127_3675105_1 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000486 169.0
CMS2_k127_369205_0 Glycosyltransferase 28 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006623 418.0
CMS2_k127_369205_1 trans-aconitate 2-methyltransferase activity K00598,K02169 - 2.1.1.144,2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 290.0
CMS2_k127_369205_2 integral membrane protein K07027 - - 0.00000000000000000000000000000000000000000000000001661 193.0
CMS2_k127_369205_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000001297 151.0
CMS2_k127_369205_4 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000001528 154.0
CMS2_k127_369205_5 hydrolase activity, acting on ester bonds - - - 0.000000000000007633 81.0
CMS2_k127_369205_6 hydrolase activity, acting on ester bonds - - - 0.00001866 48.0
CMS2_k127_3704050_0 SMART Elongator protein 3 MiaB NifB - - - 2.426e-271 846.0
CMS2_k127_3704050_1 Zinc metalloprotease (Elastase) K20274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 631.0
CMS2_k127_3704050_2 Zinc metalloprotease (Elastase) K20274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 374.0
CMS2_k127_3704050_3 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 309.0
CMS2_k127_3704050_4 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000000000000000000000000000000001297 180.0
CMS2_k127_3704050_5 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ K04034 - 1.21.98.3 0.0000000000000000000000000000000000009055 149.0
CMS2_k127_3704050_6 TPR repeat - - - 0.000000000000000009102 93.0
CMS2_k127_3704050_7 Lamin Tail Domain - - - 0.0000000000000007926 84.0
CMS2_k127_3704050_8 Lamin Tail Domain - - - 0.000000000001943 74.0
CMS2_k127_3737684_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 579.0
CMS2_k127_3737684_1 ABC 3 transport family K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 412.0
CMS2_k127_3737684_2 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 344.0
CMS2_k127_3737684_3 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 297.0
CMS2_k127_3737684_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002439 280.0
CMS2_k127_3737684_5 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003612 262.0
CMS2_k127_3737684_6 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000004379 208.0
CMS2_k127_3737684_7 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000004168 134.0
CMS2_k127_3737684_8 Periplasmic binding protein K02016 - - 0.0000001147 57.0
CMS2_k127_3737684_9 Periplasmic binding protein K02016 - - 0.0003365 45.0
CMS2_k127_3759393_0 transporter K07238 - - 0.000000000000000000000000000000000000000000000000000000000000008711 224.0
CMS2_k127_3759393_1 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000000001055 218.0
CMS2_k127_379337_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.137e-267 833.0
CMS2_k127_3810242_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001225 268.0
CMS2_k127_3810242_1 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000001364 191.0
CMS2_k127_3810242_2 - - - - 0.00000000000000000000000000000000000000002643 154.0
CMS2_k127_3810242_3 HEAT repeat - - - 0.00000000000000000000004317 113.0
CMS2_k127_3810242_4 Periplasmic copper-binding protein (NosD) K07218 - - 0.00003349 57.0
CMS2_k127_3810242_5 COG3420 Nitrous oxidase accessory protein K07218 - - 0.0009348 52.0
CMS2_k127_3822798_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 3.646e-238 747.0
CMS2_k127_3822798_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 6.64e-229 722.0
CMS2_k127_3822798_2 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 3.154e-208 657.0
CMS2_k127_3822798_3 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 514.0
CMS2_k127_3822798_4 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 332.0
CMS2_k127_3822798_5 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000001079 216.0
CMS2_k127_3822798_6 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000002874 206.0
CMS2_k127_3822798_7 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000002586 202.0
CMS2_k127_3822798_8 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000001972 141.0
CMS2_k127_3822798_9 Belongs to the 'phage' integrase family K03733 - - 0.000004044 55.0
CMS2_k127_3825391_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 521.0
CMS2_k127_3825391_1 Ribosomal protein L7/L12 dimerisation domain K02935 - - 0.00000000000000000000000000000000000000000000001067 175.0
CMS2_k127_3825391_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000002613 61.0
CMS2_k127_3941671_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 422.0
CMS2_k127_3941671_2 GvpD gas vesicle protein - - - 0.00000004946 55.0
CMS2_k127_3955662_0 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001315 282.0
CMS2_k127_3955662_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000008902 178.0
CMS2_k127_3955662_2 TIGRFAM TraB family protein - - - 0.0000007238 51.0
CMS2_k127_3990080_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 490.0
CMS2_k127_3990080_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001423 264.0
CMS2_k127_3990080_2 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000000000002236 222.0
CMS2_k127_3990080_3 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000001653 211.0
CMS2_k127_3990080_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000002338 201.0
CMS2_k127_3990080_5 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000003078 201.0
CMS2_k127_3990080_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000005203 186.0
CMS2_k127_3990080_7 Secreted repeat of unknown function - - - 0.000000000001163 69.0
CMS2_k127_3990749_0 Putative DNA-binding domain - - - 1.37e-222 699.0
CMS2_k127_3990749_1 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 497.0
CMS2_k127_3990749_2 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 369.0
CMS2_k127_3990749_3 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000281 275.0
CMS2_k127_4004420_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 1.64e-225 711.0
CMS2_k127_4004420_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004595 526.0
CMS2_k127_4004420_10 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000008141 181.0
CMS2_k127_4004420_11 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000004245 171.0
CMS2_k127_4004420_12 Domain of unknown function (DUF4198) - - - 0.00000000000000000000000000000000000005493 148.0
CMS2_k127_4004420_13 adenyl ribonucleotide binding - - - 0.0000000000000000000000000004501 117.0
CMS2_k127_4004420_14 Cellulose biosynthesis protein BcsQ K07321 - - 0.00000000000000002403 82.0
CMS2_k127_4004420_15 Cellulose biosynthesis protein BcsQ K07321 - - 0.0000000000000001203 82.0
CMS2_k127_4004420_16 Rubredoxin - - - 0.000000000001504 68.0
CMS2_k127_4004420_17 Predicted RNA-binding protein - - - 0.0000003329 55.0
CMS2_k127_4004420_18 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.000005895 55.0
CMS2_k127_4004420_19 peptidase M6 immune inhibitor A K09607 - - 0.00007506 50.0
CMS2_k127_4004420_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008244 518.0
CMS2_k127_4004420_3 FecCD transport family K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 377.0
CMS2_k127_4004420_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 288.0
CMS2_k127_4004420_5 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000032 269.0
CMS2_k127_4004420_6 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001229 258.0
CMS2_k127_4004420_7 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000156 235.0
CMS2_k127_4004420_8 RNA-binding protein of the translin family K07477 - - 0.00000000000000000000000000000000000000000000000000000000001868 212.0
CMS2_k127_4004420_9 - - - - 0.000000000000000000000000000000000000000000000000000002542 204.0
CMS2_k127_4033416_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 290.0
CMS2_k127_4033416_1 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000501 127.0
CMS2_k127_4037281_0 in RNase L inhibitor, RLI K06174 - - 9.041e-254 796.0
CMS2_k127_4037281_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000002615 215.0
CMS2_k127_4037281_2 peptidyl-prolyl cis-trans isomerase - - - 0.000000000000000000000000000000000000000000000006253 178.0
CMS2_k127_4037281_3 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000011 166.0
CMS2_k127_4037281_4 McrBC 5-methylcytosine restriction system component K19147 - - 0.0000000000000000000000000006838 117.0
CMS2_k127_4037281_5 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000001312 117.0
CMS2_k127_4037281_6 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000000000000003061 108.0
CMS2_k127_4037281_7 RNase L inhibitor, RLI - - - 0.0000000000000000000000009978 108.0
CMS2_k127_4037281_8 McrBC 5-methylcytosine restriction system component K19147 - - 0.000000002194 59.0
CMS2_k127_4037281_9 Acetyltransferase (GNAT) domain - - - 0.0001162 50.0
CMS2_k127_4048058_0 SMART Elongator protein 3 MiaB NifB K01012 - 2.8.1.6 0.0000000000000000000000000000000000514 144.0
CMS2_k127_4048058_1 PFAM methyltransferase - - - 0.00000000000000000009941 99.0
CMS2_k127_4052254_0 Permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 434.0
CMS2_k127_4052254_1 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 319.0
CMS2_k127_4052254_2 4 iron, 4 sulfur cluster binding K00176,K00523 - 1.17.1.1,1.2.7.3 0.000000000000000000000000000000000000000000004417 165.0
CMS2_k127_4052254_3 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000000000000000000000005455 130.0
CMS2_k127_4052254_4 Ferredoxin K05337 - - 0.000000000000000006907 86.0
CMS2_k127_4052254_5 - - - - 0.0002456 48.0
CMS2_k127_4070632_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000124 250.0
CMS2_k127_4070632_1 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000009295 223.0
CMS2_k127_4070632_2 radical SAM domain protein - - - 0.000000000000000000000000000001676 127.0
CMS2_k127_4085872_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 351.0
CMS2_k127_4085872_1 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000000005607 154.0
CMS2_k127_4085872_2 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000000002719 153.0
CMS2_k127_4085872_3 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000002479 150.0
CMS2_k127_4085872_4 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000004661 149.0
CMS2_k127_4085872_5 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000000000000000000000006339 142.0
CMS2_k127_4085872_6 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000003122 137.0
CMS2_k127_4085872_7 N-6 DNA Methylase - - - 0.000000006787 58.0
CMS2_k127_4085872_8 Protein of unknown function (DUF2281) - - - 0.000002213 55.0
CMS2_k127_4098180_0 protein conserved in archaea - - - 0.00000000000000000000000000000000000000000000000000000000000000008406 236.0
CMS2_k127_4098180_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000007919 71.0
CMS2_k127_4098180_2 - - - - 0.00000000005904 68.0
CMS2_k127_4102058_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 562.0
CMS2_k127_4102058_1 bis(5'-adenosyl)-triphosphatase activity K19710 GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000000005775 220.0
CMS2_k127_4102058_2 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000006845 203.0
CMS2_k127_4102058_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000001893 150.0
CMS2_k127_4102058_4 dephospho-CoA kinase activity - - - 0.0000000000000000000000000000000000003986 145.0
CMS2_k127_4102058_5 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000005787 133.0
CMS2_k127_4121365_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 456.0
CMS2_k127_4121365_1 permease K03299 - - 0.00000000000000000000000000000000000000000000000000000000000004941 229.0
CMS2_k127_4121365_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000004488 233.0
CMS2_k127_4121365_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000139 212.0
CMS2_k127_4121365_4 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000217 146.0
CMS2_k127_4121365_5 Domain of unknown function DUF123 - - - 0.0000000000000000000000000001437 117.0
CMS2_k127_4121365_6 extracellular matrix structural constituent - - - 0.000000000000001244 93.0
CMS2_k127_4126885_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 302.0
CMS2_k127_4126885_1 Ferritin-like domain - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000000000000000000000000000000000001354 239.0
CMS2_k127_4126885_2 integral membrane protein K07027 - - 0.0000000000000000000000000000000000000000000306 176.0
CMS2_k127_4126885_3 Family of unknown function (DUF5350) - - - 0.000000000002945 68.0
CMS2_k127_4126885_4 - - - - 0.00000000001745 74.0
CMS2_k127_4126885_5 PFAM TPR repeat-containing protein - - - 0.0000000004044 68.0
CMS2_k127_4132954_1 DNA polymerase beta domain protein region K07075 - - 0.000000000000000007103 85.0
CMS2_k127_4132954_2 Protein of unknown function (DUF2283) - - - 0.00000000000000001638 84.0
CMS2_k127_4132954_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000007925 78.0
CMS2_k127_4132954_4 Nucleotidyltransferase domain K07075 - - 0.000000005438 59.0
CMS2_k127_4132970_0 S-layer protein - - - 0.000000000000000000000008088 107.0
CMS2_k127_4132970_1 S-layer protein - - - 0.0000000000000000000002459 104.0
CMS2_k127_4132970_2 Nucleotidyltransferase domain K07075 - - 0.00000000000000396 81.0
CMS2_k127_4132970_3 Nucleotidyltransferase domain K07075 - - 0.00000000000007486 74.0
CMS2_k127_4145076_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 1.903e-198 630.0
CMS2_k127_4145076_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 472.0
CMS2_k127_4145076_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000003745 235.0
CMS2_k127_4145076_3 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000001494 227.0
CMS2_k127_4145076_4 archaeal Zn-finger protein - - - 0.00000000000000000000000000000002512 133.0
CMS2_k127_4145076_5 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000003954 118.0
CMS2_k127_4145076_6 VIT family - - - 0.0000000000000000000000000008054 120.0
CMS2_k127_4145076_7 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000006241 112.0
CMS2_k127_4160845_0 NhaP-type Na H and K H - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 585.0
CMS2_k127_4160845_1 COG0668 Small-conductance mechanosensitive channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000106 238.0
CMS2_k127_4160845_2 Necessary for normal cell division and for the maintenance of normal septation - - - 0.0000000000000000000000000000000000000000000000000000000000000001699 226.0
CMS2_k127_4160845_3 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000001333 185.0
CMS2_k127_4160845_4 4Fe-4S ferredoxin iron-sulfur binding domain - - - 0.00000000000000000000000000000002054 146.0
CMS2_k127_4160845_5 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000004785 121.0
CMS2_k127_4160845_7 - - - - 0.0006003 48.0
CMS2_k127_4177500_0 ATPase associated with various cellular activities - - - 0.000000000000000006815 97.0
CMS2_k127_4177500_1 PFAM transposase IS116 IS110 IS902 family - - - 0.0000000000156 71.0
CMS2_k127_4177500_2 GXGXG motif K00202 - 1.2.7.12 0.0009656 49.0
CMS2_k127_419458_0 ATPases associated with a variety of cellular activities K00400 - - 1.335e-202 646.0
CMS2_k127_419458_1 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 550.0
CMS2_k127_419458_10 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000002837 175.0
CMS2_k127_419458_11 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000005266 175.0
CMS2_k127_419458_12 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.00000000000000000000000000000000000000000186 171.0
CMS2_k127_419458_13 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000002691 141.0
CMS2_k127_419458_14 NAD(P)H dehydrogenase (quinone) activity - - - 0.00000000000000000000000000000002015 132.0
CMS2_k127_419458_15 Cysteine-rich small domain K08260 - 3.5.1.90 0.0000000000000000000000005832 116.0
CMS2_k127_419458_16 Domain of unknown function (DUF1724) - - - 0.00000000000000000007041 93.0
CMS2_k127_419458_17 - - - - 0.00000000000000069 88.0
CMS2_k127_419458_18 Domain of unknown function (DUF4405) - - - 0.000000000000002342 79.0
CMS2_k127_419458_19 Fe-S-cluster oxidoreductase K06940 - - 0.0000001818 61.0
CMS2_k127_419458_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 505.0
CMS2_k127_419458_3 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 475.0
CMS2_k127_419458_4 Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate K03340 - 1.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 437.0
CMS2_k127_419458_5 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 339.0
CMS2_k127_419458_6 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003104 281.0
CMS2_k127_419458_7 GPR1/FUN34/yaaH family K07034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009245 272.0
CMS2_k127_419458_8 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002507 254.0
CMS2_k127_419458_9 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000003432 182.0
CMS2_k127_4246667_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 605.0
CMS2_k127_4246667_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009503 504.0
CMS2_k127_4246667_2 cellular potassium ion transport K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 386.0
CMS2_k127_4246667_3 DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004402 275.0
CMS2_k127_4246667_4 PFAM transferase hexapeptide repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002505 245.0
CMS2_k127_4246667_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000008551 184.0
CMS2_k127_4246667_6 COG1606 ATP-utilizing enzymes of the PP-loop superfamily K06864 - - 0.0000000000000000000000000000000000000000000001654 176.0
CMS2_k127_4246667_7 DNA-binding transcription factor activity - - - 0.00004389 46.0
CMS2_k127_4250801_0 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 316.0
CMS2_k127_4257204_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.83e-228 720.0
CMS2_k127_4285819_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1338.0
CMS2_k127_4285819_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 2.684e-303 938.0
CMS2_k127_4285819_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000001268 103.0
CMS2_k127_4285819_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 1.046e-234 734.0
CMS2_k127_4285819_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 495.0
CMS2_k127_4285819_4 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 371.0
CMS2_k127_4285819_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007237 246.0
CMS2_k127_4285819_6 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000002621 235.0
CMS2_k127_4285819_7 COG1252 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000009274 244.0
CMS2_k127_4285819_8 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000002459 191.0
CMS2_k127_4285819_9 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.00000000000000000000000003261 110.0
CMS2_k127_4373150_0 Clp protease K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 414.0
CMS2_k127_4373150_1 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 320.0
CMS2_k127_4373150_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001665 257.0
CMS2_k127_4373150_3 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000007804 251.0
CMS2_k127_4373150_4 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000483 240.0
CMS2_k127_4373150_5 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000000000000008736 168.0
CMS2_k127_4373150_6 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000000000000109 123.0
CMS2_k127_4373150_7 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.0000000000000000000000001156 109.0
CMS2_k127_4373150_8 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000002528 94.0
CMS2_k127_4373150_9 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000000001051 88.0
CMS2_k127_4378426_0 Protein of unknown function (DUF460) K09150 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 524.0
CMS2_k127_4378426_1 PFAM elongation factor Tu domain 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 429.0
CMS2_k127_4378426_10 Predicted metal-binding protein (DUF2284) - - - 0.00000000000000000000000000000000000000000000003089 177.0
CMS2_k127_4378426_11 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000000003311 159.0
CMS2_k127_4378426_12 beta-galactosidase activity - - - 0.000000002602 65.0
CMS2_k127_4378426_2 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 412.0
CMS2_k127_4378426_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 401.0
CMS2_k127_4378426_4 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 308.0
CMS2_k127_4378426_5 sugar phosphatases of the HAD superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002768 261.0
CMS2_k127_4378426_6 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000001683 253.0
CMS2_k127_4378426_7 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000001412 208.0
CMS2_k127_4378426_8 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000001165 199.0
CMS2_k127_4378426_9 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000008736 193.0
CMS2_k127_437904_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 461.0
CMS2_k127_437904_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001444 258.0
CMS2_k127_437904_2 TIGRFAM drug resistance transporter, Bcr CflA subfamily K07552 - - 0.000000000000000000000000000000000000007633 147.0
CMS2_k127_437904_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000002879 98.0
CMS2_k127_437904_4 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000009178 84.0
CMS2_k127_437904_5 COG1403 Restriction endonuclease - - - 0.00000000001157 72.0
CMS2_k127_4382973_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 557.0
CMS2_k127_4382973_1 PFAM TrkA-N domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004635 296.0
CMS2_k127_4382973_2 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.00000000000000000001221 102.0
CMS2_k127_4382973_3 CHAT domain - - - 0.0000000000003975 76.0
CMS2_k127_4401965_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1513.0
CMS2_k127_4401965_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000003108 176.0
CMS2_k127_4401965_2 COG1943 Transposase and inactivated derivatives K07491 - - 0.000000000000000000000000000000000002044 140.0
CMS2_k127_4401965_3 PFAM Aminotransferase class I and II K05825 - - 0.0001591 47.0
CMS2_k127_4450177_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 357.0
CMS2_k127_4450177_1 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 318.0
CMS2_k127_4450177_2 NB-ARC domain - - - 0.0001815 45.0
CMS2_k127_4460943_0 transferase activity, transferring glycosyl groups K05889 - 1.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 361.0
CMS2_k127_4460943_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000001083 96.0
CMS2_k127_4460943_2 S53, subtilisin kexin sedolisin - - - 0.000000000000000006294 100.0
CMS2_k127_4492546_0 Belongs to the MCM family K10726 - - 2.995e-260 818.0
CMS2_k127_4492546_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 494.0
CMS2_k127_4492546_2 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000001318 226.0
CMS2_k127_4492546_3 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000004142 96.0
CMS2_k127_4506331_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.553e-286 892.0
CMS2_k127_4506331_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 2.006e-218 698.0
CMS2_k127_4506331_2 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 481.0
CMS2_k127_4506331_3 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000003296 165.0
CMS2_k127_4546620_0 SMART ATPase, AAA type, core K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000001058 235.0
CMS2_k127_4546620_1 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000001929 234.0
CMS2_k127_4546620_2 COG1361 S-layer domain - - - 0.000000000001722 79.0
CMS2_k127_454720_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 442.0
CMS2_k127_454720_1 Metal-dependent phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002157 256.0
CMS2_k127_454720_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000004997 236.0
CMS2_k127_454720_3 Segregation and condensation complex subunit ScpB K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000001823 236.0
CMS2_k127_454720_4 - - - - 0.0000000000000000000000000000000000000000000002102 170.0
CMS2_k127_454720_5 Segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000005408 167.0
CMS2_k127_454720_6 Transglycosylase SLT domain - - - 0.00001159 58.0
CMS2_k127_454720_7 domain protein K01342,K06894,K12287,K20276 - 3.4.21.62 0.0002413 55.0
CMS2_k127_454720_8 Leucine rich repeat - - - 0.000638 51.0
CMS2_k127_4560273_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 462.0
CMS2_k127_4560273_1 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 310.0
CMS2_k127_4560273_2 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000000000000000000000000000000000000002944 237.0
CMS2_k127_4560273_3 RDD family - - - 0.00000000000000001129 88.0
CMS2_k127_4560273_4 RNA methyltransferase, TrmH family, group 1 - - - 0.000000126 56.0
CMS2_k127_4635493_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 370.0
CMS2_k127_4635493_1 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 322.0
CMS2_k127_4635493_2 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000119 129.0
CMS2_k127_4662716_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 512.0
CMS2_k127_4684670_0 Glycogen synthase - - - 1.218e-206 659.0
CMS2_k127_4684670_1 Glycosyl transferase 4-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 468.0
CMS2_k127_4684670_2 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 370.0
CMS2_k127_4684670_3 Circadian clock protein KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000005567 241.0
CMS2_k127_4684670_4 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000009328 197.0
CMS2_k127_4684670_5 membrane - - - 0.00000000002138 69.0
CMS2_k127_4690888_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 431.0
CMS2_k127_4690888_1 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000002658 225.0
CMS2_k127_4690888_2 Domain of unknown function DUF11 K20276 - - 0.00005549 53.0
CMS2_k127_4700568_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 517.0
CMS2_k127_4700568_1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 370.0
CMS2_k127_4700568_2 S-layer protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 340.0
CMS2_k127_4700568_3 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000006161 221.0
CMS2_k127_4700568_4 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000001942 190.0
CMS2_k127_4700568_5 PFAM Pyridoxamine 5'-phosphate K07006 - - 0.0000000000000000000000000001376 120.0
CMS2_k127_4703446_0 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 336.0
CMS2_k127_4703446_1 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 331.0
CMS2_k127_4703446_2 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 324.0
CMS2_k127_4703446_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001147 269.0
CMS2_k127_4703446_4 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000006106 138.0
CMS2_k127_4703446_5 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000002274 107.0
CMS2_k127_4703446_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000001015 96.0
CMS2_k127_4703446_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000000549 89.0
CMS2_k127_4703446_8 Transcription factor Pcc1 K09741 - - 0.0000000634 58.0
CMS2_k127_4703446_9 Probably involved in the biogenesis of the ribosome K14561 - - 0.000105 50.0
CMS2_k127_4719724_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 503.0
CMS2_k127_4719724_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 365.0
CMS2_k127_4719724_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003059 268.0
CMS2_k127_4719724_3 - - - - 0.0000000000000000000000000226 111.0
CMS2_k127_4729200_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 370.0
CMS2_k127_4729200_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000001395 250.0
CMS2_k127_4762651_0 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 447.0
CMS2_k127_4762651_1 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 430.0
CMS2_k127_4762651_2 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 363.0
CMS2_k127_4762651_3 S-layer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 316.0
CMS2_k127_4762651_4 S-layer protein - - - 0.000000000000000000000000000000000000000000000004797 184.0
CMS2_k127_4762651_5 PFAM helix-turn-helix HxlR type - - - 0.00000000000000000000000000000000000000000000008119 171.0
CMS2_k127_4762651_6 - - - - 0.00009243 46.0
CMS2_k127_4788056_0 FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 324.0
CMS2_k127_4800823_0 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 1.981e-304 958.0
CMS2_k127_4800823_1 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 1.388e-258 803.0
CMS2_k127_4800823_10 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 368.0
CMS2_k127_4800823_11 GXGXG motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 308.0
CMS2_k127_4800823_12 Glutamine cyclotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 289.0
CMS2_k127_4800823_13 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001877 288.0
CMS2_k127_4800823_14 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000006398 252.0
CMS2_k127_4800823_15 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000001084 198.0
CMS2_k127_4800823_16 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000007996 142.0
CMS2_k127_4800823_17 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000002962 124.0
CMS2_k127_4800823_18 Right handed beta helix region - - - 0.00000000000000000007355 102.0
CMS2_k127_4800823_19 - K00960 - 2.7.7.6 0.0000000000000000624 84.0
CMS2_k127_4800823_2 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 1.547e-212 679.0
CMS2_k127_4800823_20 FeoA K04758 - - 0.00000000001515 68.0
CMS2_k127_4800823_21 - - - - 0.0001373 49.0
CMS2_k127_4800823_3 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 8.439e-206 660.0
CMS2_k127_4800823_4 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 2.997e-194 618.0
CMS2_k127_4800823_5 PFAM Glutamine amidotransferase, class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 539.0
CMS2_k127_4800823_6 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 502.0
CMS2_k127_4800823_7 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 430.0
CMS2_k127_4800823_8 PFAM formate nitrite transporter K06212,K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 375.0
CMS2_k127_4800823_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 367.0
CMS2_k127_4801424_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 314.0
CMS2_k127_4801424_1 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 304.0
CMS2_k127_4801424_2 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000538 126.0
CMS2_k127_4813881_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.906e-280 883.0
CMS2_k127_4813881_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.87e-200 630.0
CMS2_k127_4813881_10 Acyltransferase family - - - 0.000000000000000000000000000000003507 132.0
CMS2_k127_4813881_11 - - - - 0.00000002838 57.0
CMS2_k127_4813881_12 Carboxypeptidase K01292,K01294,K07752,K13022,K21392 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0031012,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.10,3.4.17.22,3.4.17.3 0.000005274 58.0
CMS2_k127_4813881_2 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 593.0
CMS2_k127_4813881_3 S-layer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 610.0
CMS2_k127_4813881_4 PFAM Radical SAM domain protein K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 577.0
CMS2_k127_4813881_5 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 435.0
CMS2_k127_4813881_6 ATP-grasp domain K06913 - - 0.0000000000000000000000000000000000000000000000000000000000000004682 236.0
CMS2_k127_4813881_7 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000000006926 223.0
CMS2_k127_4813881_8 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000000000000001417 199.0
CMS2_k127_4813881_9 Permease family K06901 - - 0.000000000000000000000000000000000000000007036 157.0
CMS2_k127_487994_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 342.0
CMS2_k127_487994_1 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000001796 104.0
CMS2_k127_487994_2 Pfam:DUF552 K09152 - - 0.0000000000000000001303 92.0
CMS2_k127_487994_3 ZPR1-related zinc finger protein K06874 - - 0.00001506 49.0
CMS2_k127_4886217_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 2.411e-285 889.0
CMS2_k127_4886217_1 Iron-sulfur cluster-binding domain K06871 - - 6.683e-203 640.0
CMS2_k127_4886217_10 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000002161 214.0
CMS2_k127_4886217_11 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000008449 204.0
CMS2_k127_4886217_12 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01485 - 3.5.4.1 0.000000000000000000000000000000000000000000000000000000001741 204.0
CMS2_k127_4886217_13 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000002069 183.0
CMS2_k127_4886217_14 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000001059 165.0
CMS2_k127_4886217_15 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000009917 172.0
CMS2_k127_4886217_16 PFAM Cupin - - - 0.000000000000000000000000000000000000002489 153.0
CMS2_k127_4886217_17 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000007324 148.0
CMS2_k127_4886217_18 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000002007 142.0
CMS2_k127_4886217_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 511.0
CMS2_k127_4886217_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 459.0
CMS2_k127_4886217_4 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 443.0
CMS2_k127_4886217_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 439.0
CMS2_k127_4886217_6 PFAM Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 364.0
CMS2_k127_4886217_7 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 352.0
CMS2_k127_4886217_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007143 282.0
CMS2_k127_4886217_9 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000004749 260.0
CMS2_k127_4928427_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 3.88e-202 643.0
CMS2_k127_4928427_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 353.0
CMS2_k127_4928427_2 PFAM Ferritin Dps family protein K02217 - 1.16.3.2 0.0000000000000000000000000000000000000000000000000000002051 198.0
CMS2_k127_4928427_3 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000001006 98.0
CMS2_k127_4928427_4 6-phosphogluconate dehydrogenase-like protein K00033 - 1.1.1.343,1.1.1.44 0.000000003588 59.0
CMS2_k127_5032903_0 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007369 514.0
CMS2_k127_5032903_1 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000000000000000002467 196.0
CMS2_k127_5045447_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000002036 241.0
CMS2_k127_5045447_1 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000001168 150.0
CMS2_k127_5045447_2 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000006826 136.0
CMS2_k127_5072190_0 Alpha amylase, catalytic domain - - - 3.618e-277 865.0
CMS2_k127_5072190_1 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 449.0
CMS2_k127_5072190_2 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 392.0
CMS2_k127_5072190_3 nucleoside recognition domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 382.0
CMS2_k127_5072190_4 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 295.0
CMS2_k127_5072190_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000001148 224.0
CMS2_k127_5072190_6 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000001085 186.0
CMS2_k127_5072190_7 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000003193 195.0
CMS2_k127_5072190_8 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000001067 175.0
CMS2_k127_5072190_9 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000006453 129.0
CMS2_k127_5076499_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1109.0
CMS2_k127_5076499_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 3.592e-226 705.0
CMS2_k127_5076499_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 3.652e-202 640.0
CMS2_k127_5076499_3 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 535.0
CMS2_k127_5076499_4 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 448.0
CMS2_k127_5076499_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 443.0
CMS2_k127_5076499_6 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000006102 175.0
CMS2_k127_5076499_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000001573 113.0
CMS2_k127_5076499_8 low-complexity proteins - - - 0.0000000000000000000003948 111.0
CMS2_k127_5076499_9 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000001636 63.0
CMS2_k127_5117508_0 Heat shock 70 kDa protein K04043 - - 1.416e-263 825.0
CMS2_k127_5117508_1 TCP-1/cpn60 chaperonin family K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 572.0
CMS2_k127_5117508_10 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000388 113.0
CMS2_k127_5117508_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 383.0
CMS2_k127_5117508_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008639 366.0
CMS2_k127_5117508_4 Phosphate uptake regulator - - - 0.0000000000000000000000000000000000000000000000000000000004099 214.0
CMS2_k127_5117508_5 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000554 180.0
CMS2_k127_5117508_6 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000001031 176.0
CMS2_k127_5117508_7 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000369 172.0
CMS2_k127_5117508_8 Phosphoesterase K07095 - - 0.00000000000000000000000000000000000000002259 160.0
CMS2_k127_5117508_9 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000004679 123.0
CMS2_k127_5118420_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 329.0
CMS2_k127_5118420_1 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 325.0
CMS2_k127_5118420_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000003672 241.0
CMS2_k127_5118420_3 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000007381 94.0
CMS2_k127_5118420_4 Belongs to the HesB IscA family K13628 - - 0.0006809 48.0
CMS2_k127_5128795_0 DEAD DEAH box helicase domain protein K10896 - - 8.002e-226 723.0
CMS2_k127_5128795_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000002935 239.0
CMS2_k127_5128795_2 phosphoribosylformylglycinamidine synthase K01952 - 6.3.5.3 0.0000000000000000000000000000000000000001256 158.0
CMS2_k127_5128795_3 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000007967 136.0
CMS2_k127_5128795_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000001393 89.0
CMS2_k127_5151417_0 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 419.0
CMS2_k127_5151417_1 Glycogen debranching enzyme N terminal - - - 0.000000009947 58.0
CMS2_k127_5162302_0 oxidoreductase activity - - - 0.0000000000000000000000000000004076 139.0
CMS2_k127_517021_0 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 302.0
CMS2_k127_517021_1 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001456 266.0
CMS2_k127_517021_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000004461 211.0
CMS2_k127_5201468_0 by modhmm K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 347.0
CMS2_k127_5201468_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 330.0
CMS2_k127_5201468_2 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor - - - 0.000000000000000000000000000000000000000000000000000000000000001571 237.0
CMS2_k127_5201468_3 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000002017 242.0
CMS2_k127_5201468_4 Tetratricopeptide repeat K12600 - - 0.000000000000000000000000000000000000000000002411 181.0
CMS2_k127_5201468_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001482 173.0
CMS2_k127_5201468_6 transcriptional K07729 - - 0.00000000000000000000000000005311 118.0
CMS2_k127_5201468_7 PFAM Tetratricopeptide - - - 0.0000000000000000002473 96.0
CMS2_k127_5201468_8 membrane protein (DUF2178) - - - 0.000000000000000001032 91.0
CMS2_k127_5202118_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 5.731e-205 650.0
CMS2_k127_5202118_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 381.0
CMS2_k127_5202118_10 Integral membrane protein DUF106 - - - 0.000000000000000000000000000000000000000000000000000003164 196.0
CMS2_k127_5202118_11 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000003628 186.0
CMS2_k127_5202118_12 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000003808 179.0
CMS2_k127_5202118_13 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000001226 174.0
CMS2_k127_5202118_14 binds to the 23S rRNA K02885 - - 0.00000000000000000000000000000000000000000006912 164.0
CMS2_k127_5202118_15 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000003818 165.0
CMS2_k127_5202118_16 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000009555 133.0
CMS2_k127_5202118_17 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.000000000000000000000000000000007588 131.0
CMS2_k127_5202118_18 PFAM Ribosomal protein K02912 - - 0.0000000000000000000000000000005217 127.0
CMS2_k127_5202118_19 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000173 108.0
CMS2_k127_5202118_2 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 301.0
CMS2_k127_5202118_20 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.000000000000000000001054 99.0
CMS2_k127_5202118_21 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.000000000000000000627 87.0
CMS2_k127_5202118_22 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000034 82.0
CMS2_k127_5202118_3 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 291.0
CMS2_k127_5202118_4 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 295.0
CMS2_k127_5202118_5 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000008623 221.0
CMS2_k127_5202118_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000003675 221.0
CMS2_k127_5202118_7 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000002794 218.0
CMS2_k127_5202118_8 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000002292 206.0
CMS2_k127_5202118_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000001348 199.0
CMS2_k127_5210995_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 424.0
CMS2_k127_5210995_1 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 406.0
CMS2_k127_5210995_2 - - - - 0.00000000000000009546 91.0
CMS2_k127_5212229_0 COG0464 ATPases of the AAA class K13525 - - 0.0 1007.0
CMS2_k127_5212229_1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000003515 251.0
CMS2_k127_5212229_3 PFAM PRC-barrel domain - - - 0.00000000000000001638 84.0
CMS2_k127_5242207_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916 - 6.3.1.5 0.00000000000000000000000000000000006097 136.0
CMS2_k127_5242207_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000001393 83.0
CMS2_k127_5261256_0 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009646 277.0
CMS2_k127_5261256_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000004438 126.0
CMS2_k127_5279483_0 Aminotransferase class-III K00836 GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019491,GO:0019752,GO:0032787,GO:0042399,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 571.0
CMS2_k127_5279483_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 365.0
CMS2_k127_5279483_10 L-2,4-diaminobutyric acid acetyltransferase K06718 - 2.3.1.178 0.00000000000000000001223 93.0
CMS2_k127_5279483_11 - - - - 0.000000000000001787 83.0
CMS2_k127_5279483_12 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.00000000005386 65.0
CMS2_k127_5279483_13 SMART Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000004787 71.0
CMS2_k127_5279483_14 - - - - 0.0001568 48.0
CMS2_k127_5279483_2 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 369.0
CMS2_k127_5279483_3 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 341.0
CMS2_k127_5279483_4 Serine dehydrogenase proteinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001455 285.0
CMS2_k127_5279483_5 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.0000000000000000000000000000000000000000000000000000007712 198.0
CMS2_k127_5279483_6 COGs COG3415 Transposase and inactivated derivatives K07499 - - 0.000000000000000000000000000000000000000001291 162.0
CMS2_k127_5279483_7 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000002204 164.0
CMS2_k127_5279483_8 extracellular matrix structural constituent - - - 0.000000000000000000000000001504 125.0
CMS2_k127_5279483_9 L-2,4-diaminobutyric acid acetyltransferase K06718 - 2.3.1.178 0.0000000000000000000006462 99.0
CMS2_k127_5301749_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 407.0
CMS2_k127_5301749_1 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000004257 191.0
CMS2_k127_5301749_2 Na -dependent transporter K03453 - - 0.00000000000000000000000000000000000000000000007422 180.0
CMS2_k127_5301749_3 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.00000000000000009004 81.0
CMS2_k127_5301749_4 Protein tyrosine kinase - - - 0.000000000000215 79.0
CMS2_k127_5301749_5 Ion channel - - - 0.00004446 56.0
CMS2_k127_5355129_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 421.0
CMS2_k127_5355129_1 NnrU protein K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000000000000002059 233.0
CMS2_k127_5355129_2 Cation efflux family - - - 0.0000000000000000000000000000000000000000000000009812 178.0
CMS2_k127_5355129_3 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000000002594 179.0
CMS2_k127_5355129_4 zinc metalloprotease whose natural substrate is K06974 GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000009969 179.0
CMS2_k127_5355129_5 NnrU protein K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000000209 169.0
CMS2_k127_5355129_6 - - - - 0.000000000000000017 84.0
CMS2_k127_5355129_7 response to oxidative stress K04063 - - 0.00000000000007962 77.0
CMS2_k127_5355129_8 Pentapeptide repeats (9 copies) - - - 0.00000005837 63.0
CMS2_k127_5380047_0 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 339.0
CMS2_k127_5380047_1 Belongs to the Fur family K09825 - - 0.0000000000000000000000004153 111.0
CMS2_k127_5380047_2 RNA-binding protein homologous to eukaryotic snRNP - - - 0.00000003294 55.0
CMS2_k127_5380047_3 PFAM NADPH-dependent FMN reductase - - - 0.0001344 46.0
CMS2_k127_5440746_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 460.0
CMS2_k127_5440746_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000004616 252.0
CMS2_k127_5446710_0 Uncharacterized protein conserved in archaea (DUF2193) - - - 2.313e-269 835.0
CMS2_k127_5446710_1 Major intrinsic protein K02440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 376.0
CMS2_k127_5446710_2 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000000000000000000002635 199.0
CMS2_k127_5446710_3 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.00000000000000000000000000000001275 128.0
CMS2_k127_546144_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 440.0
CMS2_k127_546144_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004329 276.0
CMS2_k127_546144_2 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000003202 225.0
CMS2_k127_5461835_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 562.0
CMS2_k127_5461835_1 myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 530.0
CMS2_k127_5461835_10 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000001827 102.0
CMS2_k127_5461835_11 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000005809 101.0
CMS2_k127_5461835_12 Protein of unknown function (DUF3467) - - - 0.00000000000000000001687 94.0
CMS2_k127_5461835_2 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 529.0
CMS2_k127_5461835_3 peptidase M42 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 457.0
CMS2_k127_5461835_4 shikimate kinase activity K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 299.0
CMS2_k127_5461835_5 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 301.0
CMS2_k127_5461835_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000003165 175.0
CMS2_k127_5461835_7 Histidine kinase - - - 0.00000000000000000000000000000000000000007588 157.0
CMS2_k127_5461835_8 Lycopene cyclase protein - - - 0.00000000000000000000000001006 115.0
CMS2_k127_5461835_9 Universal stress protein family - - - 0.000000000000000000000003958 107.0
CMS2_k127_5509482_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1062.0
CMS2_k127_5540672_0 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 470.0
CMS2_k127_5540672_1 - K04096 - - 0.0000000000000000000000000000000000000003509 155.0
CMS2_k127_554109_0 PFAM Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 403.0
CMS2_k127_554109_1 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002003 277.0
CMS2_k127_554109_2 4Fe-4S binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000003489 223.0
CMS2_k127_554109_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000001397 220.0
CMS2_k127_554109_4 Cupin domain - - - 0.00000000000000000000000000000000000000005841 155.0
CMS2_k127_554109_5 protein conserved in archaea K09732 - - 0.00000000000000000000000000001202 121.0
CMS2_k127_554109_6 Uncharacterized protein conserved in archaea (DUF2209) - - - 0.0000000000000000000000000478 112.0
CMS2_k127_554109_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.0000000000000000000000019 105.0
CMS2_k127_554109_8 Transposase DDE domain - - - 0.0000001158 55.0
CMS2_k127_5548344_0 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000001767 138.0
CMS2_k127_5548344_1 - - - - 0.00000000000000007718 87.0
CMS2_k127_5548344_2 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.00001984 53.0
CMS2_k127_5668997_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.514e-311 979.0
CMS2_k127_5668997_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 4.751e-237 751.0
CMS2_k127_5668997_10 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 305.0
CMS2_k127_5668997_11 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002118 284.0
CMS2_k127_5668997_12 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001799 234.0
CMS2_k127_5668997_13 TIGRFAM sulfite reductase, subunit A K16950 - - 0.000000000000000000000000000000000000000000000000000000000002286 221.0
CMS2_k127_5668997_14 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000003295 183.0
CMS2_k127_5668997_15 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000000000000000000000000000000226 153.0
CMS2_k127_5668997_16 Pfam:Nol1_Nop2_Fmu_2 - - - 0.00000000000000000000000201 112.0
CMS2_k127_5668997_17 TRAM domain - - - 0.00000000000000000006695 91.0
CMS2_k127_5668997_18 TRAM domain - - - 0.000000000000000005086 87.0
CMS2_k127_5668997_2 Belongs to the group II decarboxylase family. MfnA subfamily K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005747 416.0
CMS2_k127_5668997_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 401.0
CMS2_k127_5668997_4 oligopeptide dipeptide ABC transporter K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 368.0
CMS2_k127_5668997_5 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 371.0
CMS2_k127_5668997_6 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 368.0
CMS2_k127_5668997_7 SBF-like CPA transporter family (DUF4137) K03453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 338.0
CMS2_k127_5668997_8 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 332.0
CMS2_k127_5668997_9 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 326.0
CMS2_k127_571361_0 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 331.0
CMS2_k127_571361_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004076 255.0
CMS2_k127_571361_2 Nitroreductase family - - - 0.00000009682 56.0
CMS2_k127_5717151_0 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 332.0
CMS2_k127_5717151_1 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.00000000000000000000000000000000000000000001386 164.0
CMS2_k127_5717151_2 PFAM TspO MBR family protein K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.0000000000000000000000000001717 117.0
CMS2_k127_573264_0 Heavy-metal-associated domain K01534 - 3.6.3.3,3.6.3.5 7.454e-258 816.0
CMS2_k127_573264_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.863e-232 748.0
CMS2_k127_573264_2 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 562.0
CMS2_k127_573264_3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 465.0
CMS2_k127_573264_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000006766 231.0
CMS2_k127_573264_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000006652 192.0
CMS2_k127_573264_6 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000001559 179.0
CMS2_k127_573264_7 - - - - 0.000000000000000000000000000000000000000000000001613 177.0
CMS2_k127_573264_8 Protein of unknown function (DUF2551) - - - 0.0000000000000000000001394 100.0
CMS2_k127_573264_9 cell adhesion K11904 - - 0.000008319 57.0
CMS2_k127_5759673_0 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003735 559.0
CMS2_k127_5759673_1 PINc domain ribonuclease K09006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 300.0
CMS2_k127_5759673_2 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000912 249.0
CMS2_k127_5759673_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000001603 88.0
CMS2_k127_5760746_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 317.0
CMS2_k127_5760746_1 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000003256 73.0
CMS2_k127_5760746_2 Radical SAM superfamily - - - 0.000000006614 59.0
CMS2_k127_5775209_0 Erythromycin esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 378.0
CMS2_k127_5775209_1 Isochorismatase family K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000001984 244.0
CMS2_k127_5775209_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000302 241.0
CMS2_k127_5791308_0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 303.0
CMS2_k127_5791308_1 Formate dehydrogenase alpha subunit K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 0.0000000000000000000000000000000000000005884 163.0
CMS2_k127_5854986_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 478.0
CMS2_k127_5854986_1 Putative Fe-S cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 395.0
CMS2_k127_5854986_10 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000002731 111.0
CMS2_k127_5854986_11 low-complexity proteins - - - 0.0000000000000000000005181 108.0
CMS2_k127_5854986_12 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000003384 85.0
CMS2_k127_5854986_13 COG0642 Signal transduction histidine kinase - - - 0.00000000000000006909 96.0
CMS2_k127_5854986_14 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000000000001462 80.0
CMS2_k127_5854986_15 - - - - 0.0000005787 59.0
CMS2_k127_5854986_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 340.0
CMS2_k127_5854986_3 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006474 256.0
CMS2_k127_5854986_4 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000000000000001215 224.0
CMS2_k127_5854986_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000000000000000000000000000000000000000000308 188.0
CMS2_k127_5854986_6 DsrE/DsrF-like family K07235 - - 0.00000000000000000000000000000000000000000000002294 176.0
CMS2_k127_5854986_7 protein involved in the oxidation of intracellular sulfur K07236 - - 0.0000000000000000000000000000000000000000000167 165.0
CMS2_k127_5854986_8 Domain of unknown function (DUF1805) - - - 0.00000000000000000000000000001439 121.0
CMS2_k127_5854986_9 DsrH like protein K07237 - - 0.0000000000000000000000001198 109.0
CMS2_k127_5911131_0 Belongs to the NifD NifK NifE NifN family K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 559.0
CMS2_k127_5911131_1 Belongs to the NifD NifK NifE NifN family K02592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 450.0
CMS2_k127_5911131_2 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 309.0
CMS2_k127_5911131_3 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 291.0
CMS2_k127_5911131_4 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000001041 258.0
CMS2_k127_5911131_5 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000004477 57.0
CMS2_k127_593857_0 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000000000000005084 161.0
CMS2_k127_593857_1 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000000001099 151.0
CMS2_k127_593857_2 DNA-binding transcription factor activity - - - 0.00000000000003009 77.0
CMS2_k127_5986664_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 612.0
CMS2_k127_5986664_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 374.0
CMS2_k127_5986664_10 O-methyltransferase - - - 0.000001214 55.0
CMS2_k127_5986664_2 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 321.0
CMS2_k127_5986664_3 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001658 278.0
CMS2_k127_5986664_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000002978 233.0
CMS2_k127_5986664_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000000000005606 168.0
CMS2_k127_5986664_6 Lycopene cyclase protein - - - 0.00000000000000000000000000000000002944 152.0
CMS2_k127_5986664_7 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000000000005066 132.0
CMS2_k127_5986664_8 exosome subunit K07581 - - 0.0000000000000001057 85.0
CMS2_k127_5986664_9 - - - - 0.0000000000000002569 85.0
CMS2_k127_5994422_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 505.0
CMS2_k127_5994422_1 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 289.0
CMS2_k127_5994422_2 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001603 262.0
CMS2_k127_5994422_3 Fumarase C-terminus K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000001188 179.0
CMS2_k127_5994422_4 Protein of unknown function (DUF434) - - - 0.0000000000000000000000000000000000000000001157 168.0
CMS2_k127_6052212_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 464.0
CMS2_k127_6052212_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 364.0
CMS2_k127_6121234_0 PFAM ABC transporter K00400 - - 9.502e-222 698.0
CMS2_k127_6121234_1 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 577.0
CMS2_k127_6121234_2 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 454.0
CMS2_k127_6121234_3 methanogenesis marker protein 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 378.0
CMS2_k127_6121234_4 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000006971 195.0
CMS2_k127_6121234_5 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000003087 148.0
CMS2_k127_6121234_6 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000004358 132.0
CMS2_k127_6121234_7 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000002177 108.0
CMS2_k127_6124083_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 534.0
CMS2_k127_6124083_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000001095 244.0
CMS2_k127_6124083_2 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000004881 119.0
CMS2_k127_6144298_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 490.0
CMS2_k127_6144298_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 463.0
CMS2_k127_6144298_2 Thioredoxin K03671 - - 0.00000000009095 71.0
CMS2_k127_6178003_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 616.0
CMS2_k127_6178003_1 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 580.0
CMS2_k127_6178003_10 - - - - 0.0000000000000000000000000000000000000000003258 167.0
CMS2_k127_6178003_11 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000001372 148.0
CMS2_k127_6178003_12 queuosine metabolic process K04068,K10026 - 1.97.1.4,4.3.99.3 0.0000000000000000000000000000000000005921 150.0
CMS2_k127_6178003_13 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000003215 118.0
CMS2_k127_6178003_14 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000004677 87.0
CMS2_k127_6178003_15 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000654 86.0
CMS2_k127_6178003_16 - - - - 0.000000000000004712 79.0
CMS2_k127_6178003_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 526.0
CMS2_k127_6178003_3 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009238 439.0
CMS2_k127_6178003_4 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 313.0
CMS2_k127_6178003_5 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 293.0
CMS2_k127_6178003_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001398 224.0
CMS2_k127_6178003_7 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000001559 218.0
CMS2_k127_6178003_8 RibD C-terminal domain K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000001032 208.0
CMS2_k127_6178003_9 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000002265 173.0
CMS2_k127_6183317_0 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 467.0
CMS2_k127_6183317_1 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000000000000000000000009995 174.0
CMS2_k127_6183317_2 Arginase family K01476,K01480 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.1,3.5.3.11 0.00000000000000000000000000005348 124.0
CMS2_k127_6183317_3 TOBE domain - - - 0.0000000000000004317 79.0
CMS2_k127_6197102_0 Peptidase S8 - - - 0.00000000000000000000000000000000000000000000000000000000000000002998 246.0
CMS2_k127_6197102_1 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000002427 160.0
CMS2_k127_6197102_2 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000002415 118.0
CMS2_k127_6197102_3 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000003528 115.0
CMS2_k127_6233949_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 432.0
CMS2_k127_6233949_1 radical SAM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 423.0
CMS2_k127_6233949_10 Domain of unknown function (DUF333) K09712 - - 0.000000000000000000001288 104.0
CMS2_k127_6233949_11 PFAM nuclease (SNase domain protein) - - - 0.00000000000000000004452 96.0
CMS2_k127_6233949_12 PFAM nuclease (SNase domain protein) - - - 0.000000000000000003291 94.0
CMS2_k127_6233949_13 Domain of unknown function (DUF333) K09712 - - 0.00000000000000003532 91.0
CMS2_k127_6233949_15 Aggrecan K06792,K06793 GO:0000323,GO:0001501,GO:0001502,GO:0001503,GO:0002062,GO:0002063,GO:0003674,GO:0005198,GO:0005201,GO:0005488,GO:0005509,GO:0005539,GO:0005540,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005773,GO:0005775,GO:0005794,GO:0005796,GO:0006022,GO:0006023,GO:0006024,GO:0006026,GO:0006027,GO:0006029,GO:0006082,GO:0006508,GO:0006790,GO:0006807,GO:0007275,GO:0007399,GO:0007417,GO:0007507,GO:0007568,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009268,GO:0009314,GO:0009605,GO:0009612,GO:0009628,GO:0009629,GO:0009653,GO:0009743,GO:0009746,GO:0009749,GO:0009887,GO:0009888,GO:0009987,GO:0010033,GO:0010259,GO:0010447,GO:0012505,GO:0014070,GO:0016043,GO:0018146,GO:0019538,GO:0021510,GO:0030154,GO:0030166,GO:0030198,GO:0030199,GO:0030203,GO:0030334,GO:0030336,GO:0031012,GO:0031406,GO:0031974,GO:0032501,GO:0032502,GO:0032879,GO:0034284,GO:0034645,GO:0036094,GO:0036477,GO:0040012,GO:0040013,GO:0042221,GO:0042339,GO:0042340,GO:0042493,GO:0042995,GO:0043005,GO:0043025,GO:0043062,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044272,GO:0044273,GO:0044281,GO:0044297,GO:0044420,GO:0044421,GO:0044422,GO:0044424,GO:0044431,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0048468,GO:0048513,GO:0048519,GO:0048523,GO:0048705,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051216,GO:0051270,GO:0051271,GO:0051716,GO:0060591,GO:0061448,GO:0062023,GO:0065007,GO:0070013,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071704,GO:0071840,GO:0072359,GO:0072534,GO:0097367,GO:0097435,GO:0097458,GO:0098743,GO:0120025,GO:1901135,GO:1901136,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901700,GO:1903510,GO:2000145,GO:2000146 - 0.00000000005753 75.0
CMS2_k127_6233949_2 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 356.0
CMS2_k127_6233949_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002948 264.0
CMS2_k127_6233949_4 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002072 267.0
CMS2_k127_6233949_5 UbiA prenyltransferase family K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000009094 263.0
CMS2_k127_6233949_6 Rubrerythrin - - - 0.000000000000000000000000000000000000000005514 156.0
CMS2_k127_6233949_7 amino acid activation for nonribosomal peptide biosynthetic process K20952 - - 0.000000000000000000000000000000000003281 155.0
CMS2_k127_6236757_0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain K13747 - 4.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007539 469.0
CMS2_k127_6236757_1 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 410.0
CMS2_k127_6236757_10 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.0000001901 54.0
CMS2_k127_6236757_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 361.0
CMS2_k127_6236757_3 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001878 244.0
CMS2_k127_6236757_4 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000806 217.0
CMS2_k127_6236757_5 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00000000000000000000000006179 119.0
CMS2_k127_6236757_6 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures - - - 0.00000000000000000000002404 104.0
CMS2_k127_6236757_7 NurA - - - 0.000000000000000000002269 107.0
CMS2_k127_6236757_8 - - - - 0.0000000000000000005667 91.0
CMS2_k127_6236757_9 COG3436 Transposase and inactivated derivatives K07484 - - 0.00000000000006527 74.0
CMS2_k127_6298973_0 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 343.0
CMS2_k127_6298973_1 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000000000003224 194.0
CMS2_k127_6298973_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000004762 176.0
CMS2_k127_6298973_3 4 iron, 4 sulfur cluster binding K00176,K00523 - 1.17.1.1,1.2.7.3 0.000000000000000000000000000000000000000000006058 165.0
CMS2_k127_6298973_4 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.000000000000000000000000000001674 125.0
CMS2_k127_6298973_5 DGC domain - - - 0.000000000000000000000000000003194 123.0
CMS2_k127_6298973_6 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000000000001408 101.0
CMS2_k127_6298973_7 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000000000005627 96.0
CMS2_k127_6298973_8 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000001416 103.0
CMS2_k127_6298973_9 - - - - 0.00001801 51.0
CMS2_k127_6301893_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 338.0
CMS2_k127_6301893_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 305.0
CMS2_k127_6356013_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007924 273.0
CMS2_k127_6356013_1 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005705 252.0
CMS2_k127_6356013_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000001846 215.0
CMS2_k127_6356013_3 Tetratricopeptide repeat - - - 0.0006648 44.0
CMS2_k127_637164_0 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 492.0
CMS2_k127_637164_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000004422 207.0
CMS2_k127_637164_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000002707 123.0
CMS2_k127_6373400_0 ATP-citrate synthase (ATP-citrate (Pro-S-)-lyase)(Citrate cleavage enzyme) K15230 - 2.3.3.8 4.178e-232 736.0
CMS2_k127_6373400_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 571.0
CMS2_k127_6373400_2 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 410.0
CMS2_k127_6373400_3 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000001351 175.0
CMS2_k127_6373400_4 PFAM Cold-shock protein DNA-binding K03704 - - 0.0000000000002489 71.0
CMS2_k127_6399919_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009743 529.0
CMS2_k127_6399919_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 445.0
CMS2_k127_6399919_10 Molybdopterin converting factor, small subunit K03636 - - 0.000000000000000005993 87.0
CMS2_k127_6399919_11 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.0000001407 60.0
CMS2_k127_6399919_12 Tetratricopeptide repeat - - - 0.0008666 51.0
CMS2_k127_6399919_2 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001237 277.0
CMS2_k127_6399919_3 PFAM TfuA domain protein, core - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001625 251.0
CMS2_k127_6399919_4 methyltransferase activity K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000003163 201.0
CMS2_k127_6399919_5 PFAM GvpD gas vesicle - - - 0.00000000000000000000000000000000000000000000000003735 196.0
CMS2_k127_6399919_6 Domain of unknown function (DUF1890) - - - 0.00000000000000000000000000000000000000000000008721 173.0
CMS2_k127_6399919_7 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.00000000000000000000000000000000000005493 148.0
CMS2_k127_6399919_8 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000005176 132.0
CMS2_k127_6399919_9 Domain of unknown function (DUF1894) - - - 0.000000000000000000000000000000006154 129.0
CMS2_k127_6453428_0 Involved in cell shape control K22222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 429.0
CMS2_k127_6453428_1 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 335.0
CMS2_k127_6453428_2 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 326.0
CMS2_k127_6453428_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 290.0
CMS2_k127_6453428_4 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004311 249.0
CMS2_k127_6453428_5 Psort location Periplasmic, score 9.44 K07218 - - 0.0000000000007212 81.0
CMS2_k127_6453428_6 domain protein K02487,K03832,K06596,K13735 - - 0.00000006124 64.0
CMS2_k127_6453428_7 Right handed beta helix region - - - 0.00000731 51.0
CMS2_k127_6542859_0 PFAM peptidase U32 K08303 - - 3.865e-246 786.0
CMS2_k127_6542859_1 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 289.0
CMS2_k127_6542859_2 Uncharacterized protein domain (DUF2202) - - - 0.00000000000000000000000000000000000000000000000000003981 195.0
CMS2_k127_6542859_3 PFAM basic membrane lipoprotein K07335 - - 0.0000000000000003211 79.0
CMS2_k127_6542859_4 Protein of unknown function (DUF998) - - - 0.00000000001355 68.0
CMS2_k127_6594331_0 Probable transposase K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 566.0
CMS2_k127_6594331_1 domain, Protein K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 431.0
CMS2_k127_6594331_2 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 371.0
CMS2_k127_6594331_3 C-terminal domain of CHU protein family - - - 0.0000002345 62.0
CMS2_k127_6602599_0 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 443.0
CMS2_k127_6602599_1 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001573 271.0
CMS2_k127_6606169_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.625e-238 766.0
CMS2_k127_6606169_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 472.0
CMS2_k127_6606169_10 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.0000000000000000000000000006997 120.0
CMS2_k127_6606169_11 Belongs to the UPF0146 family K09713 - - 0.0000000000000000000006715 102.0
CMS2_k127_6606169_12 serine threonine protein kinase - - - 0.0000000000004124 78.0
CMS2_k127_6606169_2 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 473.0
CMS2_k127_6606169_3 Protein of unknown function (DUF1254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 376.0
CMS2_k127_6606169_4 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 358.0
CMS2_k127_6606169_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 332.0
CMS2_k127_6606169_6 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000012 295.0
CMS2_k127_6606169_7 Protein of unknown function (DUF1614) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003266 265.0
CMS2_k127_6606169_8 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004979 267.0
CMS2_k127_6606169_9 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000001053 197.0
CMS2_k127_6617386_0 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 394.0
CMS2_k127_6617386_1 Propeptide_C25 - - - 0.00000000000000000000000000000000000000000000000000000000000000001542 248.0
CMS2_k127_6617386_2 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.0000000000000000000000000000000000000000000000000000001034 219.0
CMS2_k127_6617386_3 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.000000000000000000004781 98.0
CMS2_k127_6625414_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000002986 155.0
CMS2_k127_6625414_1 - - - - 0.0000000000000000000000000000003682 128.0
CMS2_k127_6625414_2 - - - - 0.000000000000004289 81.0
CMS2_k127_6625843_0 S1, RNA binding domain K06959 - - 5.513e-304 947.0
CMS2_k127_6625843_1 PFAM peptidase - - - 0.0000000000000000000000000000004612 124.0
CMS2_k127_6625843_2 - - - - 0.0000000000000000000029 99.0
CMS2_k127_6626272_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 586.0
CMS2_k127_6643872_0 NADH ubiquinone oxidoreductase, 20 Kd subunit K22159 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000008223 244.0
CMS2_k127_6643872_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K22161 - 1.5.98.3 0.000000000000000000000000000000000000000000000000000000000006987 221.0
CMS2_k127_6643872_2 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K22160 - 1.5.98.3 0.000000000000000000000000000000000001827 152.0
CMS2_k127_6645795_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 621.0
CMS2_k127_6645795_1 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 432.0
CMS2_k127_6645795_2 MscS Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 332.0
CMS2_k127_6645795_3 Dimerisation domain of Zinc Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 319.0
CMS2_k127_6645795_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 299.0
CMS2_k127_6645795_5 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000142 289.0
CMS2_k127_6645795_6 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001197 265.0
CMS2_k127_6645795_7 Na Ca antiporter, CaCA family K07301 GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516 - 0.00000000000000000000000000000000000000000007914 165.0
CMS2_k127_6645795_8 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000002005 150.0
CMS2_k127_6649726_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 415.0
CMS2_k127_6649726_1 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002894 276.0
CMS2_k127_6649726_2 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000135 72.0
CMS2_k127_6668204_0 PFAM Glutamine synthetase, catalytic K01915 - 6.3.1.2 3.985e-204 643.0
CMS2_k127_6668204_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 480.0
CMS2_k127_6668204_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 421.0
CMS2_k127_6668204_3 Ribbon-helix-helix protein, copG family - - - 0.00000000000000000000000000000000000000000000000000003047 193.0
CMS2_k127_6668204_4 PFAM PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000009075 203.0
CMS2_k127_6668204_6 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000004407 97.0
CMS2_k127_6668204_7 FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - 0.0000000000000005878 83.0
CMS2_k127_6668204_8 - - - - 0.000000002416 65.0
CMS2_k127_668592_0 LOR SDH bifunctional enzyme conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 522.0
CMS2_k127_668592_1 RNA ligase K07468 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 373.0
CMS2_k127_668592_10 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000004018 143.0
CMS2_k127_668592_11 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000182 124.0
CMS2_k127_668592_12 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000002523 127.0
CMS2_k127_668592_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0007204 44.0
CMS2_k127_668592_2 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 302.0
CMS2_k127_668592_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 282.0
CMS2_k127_668592_4 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 287.0
CMS2_k127_668592_5 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009016 282.0
CMS2_k127_668592_6 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008448 260.0
CMS2_k127_668592_7 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002292 229.0
CMS2_k127_668592_8 RIO1 family K08851 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000005679 221.0
CMS2_k127_668592_9 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000006521 179.0
CMS2_k127_6709689_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.927e-224 711.0
CMS2_k127_6709689_1 NADPH-quinone reductase (modulator of drug activity B) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 299.0
CMS2_k127_6709689_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000881 211.0
CMS2_k127_6709689_4 DUF3160 - - - 0.00000000000000000000000000000000000000009883 156.0
CMS2_k127_6709689_5 Tetratricopeptide repeat K12600 - - 0.00000000000000000000000000000005738 134.0
CMS2_k127_6709689_6 - - - - 0.000000000006596 71.0
CMS2_k127_6709689_7 PBS lyase HEAT domain protein repeat-containing protein K22221 - - 0.00009437 51.0
CMS2_k127_6710258_0 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 365.0
CMS2_k127_6710258_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000001985 201.0
CMS2_k127_6710258_2 response regulator, receiver - - - 0.000000000000000000006643 98.0
CMS2_k127_6710258_3 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000004585 68.0
CMS2_k127_6716440_0 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007737 243.0
CMS2_k127_6716440_1 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001146 254.0
CMS2_k127_6716440_10 PFAM Integrase core domain K07497 - - 0.0000001105 55.0
CMS2_k127_6716440_2 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000009783 233.0
CMS2_k127_6716440_3 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000004043 226.0
CMS2_k127_6716440_4 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000007357 228.0
CMS2_k127_6716440_5 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000001077 211.0
CMS2_k127_6716440_6 Domain of unknown function (DUF4870) K09940 - - 0.00000000000000000000000000000000009213 141.0
CMS2_k127_6716440_7 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000453 117.0
CMS2_k127_6716440_8 AAA ATPase domain - - - 0.0000000000000000008591 93.0
CMS2_k127_6716440_9 Rubrerythrin - - - 0.000000000003941 66.0
CMS2_k127_6732726_0 PFAM nucleoside recognition domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002935 223.0
CMS2_k127_6732726_1 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000001412 200.0
CMS2_k127_6734537_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 1.972e-229 717.0
CMS2_k127_6734537_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 412.0
CMS2_k127_6734537_2 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008728 356.0
CMS2_k127_6734537_3 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000004091 258.0
CMS2_k127_6734537_4 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.0000000000000000000000000000000000000000000003822 181.0
CMS2_k127_6734537_5 - - - - 0.000000000000000000000000000000000000000000004089 168.0
CMS2_k127_6734537_6 Uncharacterized protein domain (DUF2202) - - - 0.000000000000000000000000000000000000000001127 171.0
CMS2_k127_6734537_7 methyltransferase K15256 - - 0.0000000000008271 77.0
CMS2_k127_6734537_8 Glucokinase K00845 - 2.7.1.2 0.0008386 48.0
CMS2_k127_6781976_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 464.0
CMS2_k127_6781976_1 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000000001059 146.0
CMS2_k127_6781976_2 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000012 121.0
CMS2_k127_6781976_3 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000002076 111.0
CMS2_k127_6787351_0 synthetase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 526.0
CMS2_k127_6787351_1 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000996 275.0
CMS2_k127_6787351_2 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000004906 171.0
CMS2_k127_6811736_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.316e-299 934.0
CMS2_k127_6811736_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 9.274e-279 870.0
CMS2_k127_6811736_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 586.0
CMS2_k127_6811736_3 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 494.0
CMS2_k127_6811736_4 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 437.0
CMS2_k127_6811736_5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 361.0
CMS2_k127_6811736_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000005641 177.0
CMS2_k127_6811736_7 PFAM regulatory protein, ArsR K07721 - - 0.000001397 56.0
CMS2_k127_681496_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.435e-238 748.0
CMS2_k127_681496_1 Sodium:solute symporter family K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 537.0
CMS2_k127_681496_10 - - - - 0.000768 51.0
CMS2_k127_681496_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 402.0
CMS2_k127_681496_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 325.0
CMS2_k127_681496_4 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 316.0
CMS2_k127_681496_5 to cation transporters K07244 - - 0.000000000000000000000000000000000000000000000000000000000000000000001146 253.0
CMS2_k127_681496_6 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000002016 166.0
CMS2_k127_681496_7 S-layer protein - - - 0.00000000000000000000000000000000000000001027 163.0
CMS2_k127_681496_8 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000007852 150.0
CMS2_k127_681496_9 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000009131 147.0
CMS2_k127_6823588_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007772 267.0
CMS2_k127_6823588_1 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001058 268.0
CMS2_k127_6823588_2 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.000000000000000000000000359 115.0
CMS2_k127_683042_0 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 2.411e-210 662.0
CMS2_k127_683042_1 formate dehydrogenase (NAD+) activity K00123,K05299 - 1.17.1.10,1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 357.0
CMS2_k127_6883646_0 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases K01322 - 3.4.21.26 7.291e-270 841.0
CMS2_k127_6883646_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009279 282.0
CMS2_k127_6883684_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 482.0
CMS2_k127_6883684_1 serine-type endopeptidase activity K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000003063 173.0
CMS2_k127_6883684_2 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000002042 137.0
CMS2_k127_6883684_3 Transcription factor Pcc1 K09741 - - 0.0000004215 55.0
CMS2_k127_6963776_0 KH, type 1, domain K07041 - - 1.917e-315 975.0
CMS2_k127_6963776_1 DEAD DEAH box helicase domain protein K03725 - - 3.493e-225 723.0
CMS2_k127_6963776_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000697 250.0
CMS2_k127_6963776_11 Membrane protein of unknown function DUF63 - - - 0.0000000000000000000000000000000000000000000000000000000000009292 220.0
CMS2_k127_6963776_12 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.000000000000000000000000000000000000000000000000000000001111 206.0
CMS2_k127_6963776_13 ArsR transcriptional regulator - - - 0.000000000000000000000000000000000000000000000004152 179.0
CMS2_k127_6963776_14 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000687 128.0
CMS2_k127_6963776_15 4Fe-4S binding domain - - - 0.000000000000000000000000000184 116.0
CMS2_k127_6963776_16 Domain of unknown function DUF11 - - - 0.00000000000000000000000001374 125.0
CMS2_k127_6963776_2 PFAM PilT protein domain protein K06865 - - 2.045e-217 690.0
CMS2_k127_6963776_3 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 482.0
CMS2_k127_6963776_4 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 389.0
CMS2_k127_6963776_5 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 375.0
CMS2_k127_6963776_6 by modhmm K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 366.0
CMS2_k127_6963776_7 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 332.0
CMS2_k127_6963776_8 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002503 260.0
CMS2_k127_6963776_9 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000002687 248.0
CMS2_k127_697448_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009834 496.0
CMS2_k127_697448_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000006241 246.0
CMS2_k127_7001122_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000564 338.0
CMS2_k127_7001122_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 310.0
CMS2_k127_7001122_2 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000002424 186.0
CMS2_k127_7065731_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002669 238.0
CMS2_k127_7065731_1 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.000000000000000000000000000000000000000000000003674 179.0
CMS2_k127_7067012_0 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 355.0
CMS2_k127_7067012_1 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.0000000000000002013 83.0
CMS2_k127_707918_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 1.71e-243 764.0
CMS2_k127_707918_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002016 262.0
CMS2_k127_707918_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000001138 224.0
CMS2_k127_707918_3 PFAM H transporting two-sector ATPase C subunit K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 - 0.0000000000000000000000000000000000000217 151.0
CMS2_k127_707918_4 Belongs to the V-ATPase 116 kDa subunit family K02123 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000007638 136.0
CMS2_k127_707918_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000001939 131.0
CMS2_k127_707918_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000000000008732 93.0
CMS2_k127_710298_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 601.0
CMS2_k127_710298_1 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 329.0
CMS2_k127_710298_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 292.0
CMS2_k127_710298_3 Belongs to the precorrin methyltransferase family K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000325 70.0
CMS2_k127_713459_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000004272 152.0
CMS2_k127_713459_1 - - - - 0.000000000000000000000000000000000001114 144.0
CMS2_k127_713459_2 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000494 121.0
CMS2_k127_713459_3 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000163 88.0
CMS2_k127_733788_0 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 299.0
CMS2_k127_733788_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001491 290.0
CMS2_k127_733788_2 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001597 261.0
CMS2_k127_733788_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000003204 91.0
CMS2_k127_804826_0 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 324.0
CMS2_k127_804826_1 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000002642 213.0
CMS2_k127_804826_2 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000004974 183.0
CMS2_k127_804826_3 Membrane - - - 0.0000000000000000000000000000000009869 135.0
CMS2_k127_804826_4 Alternative locus ID K15383 - - 0.00000000000007157 77.0
CMS2_k127_816077_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 1.529e-209 668.0
CMS2_k127_816077_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000002372 144.0
CMS2_k127_831529_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 7.598e-262 822.0
CMS2_k127_831529_1 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 316.0
CMS2_k127_831529_2 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000004297 247.0
CMS2_k127_834267_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 417.0
CMS2_k127_834267_1 PFAM Alcohol dehydrogenase GroES domain protein K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 314.0
CMS2_k127_834267_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000001409 222.0
CMS2_k127_834267_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000669 206.0
CMS2_k127_834267_4 ATPase activity K16786,K16787 - - 0.000000002796 65.0
CMS2_k127_842980_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 581.0
CMS2_k127_842980_1 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000701 283.0
CMS2_k127_842980_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000001933 270.0
CMS2_k127_842980_3 KH domain protein K06961 - - 0.0000000000000000000000000000000000000000000000000000000000000000009231 231.0
CMS2_k127_842980_4 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000281 192.0
CMS2_k127_842980_5 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000058 145.0
CMS2_k127_842980_6 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000006204 134.0
CMS2_k127_842980_7 DNA-dependent DNA replication K02315,K07452,K11144 - - 0.00000000000000000001124 94.0
CMS2_k127_86895_0 PFAM Aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 502.0
CMS2_k127_86895_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08256 - 2.4.1.345,2.7.8.5 0.00000000000000000002798 99.0
CMS2_k127_86895_2 - K03686 - - 0.000000000000005861 76.0
CMS2_k127_88353_0 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 375.0
CMS2_k127_88353_1 FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001198 282.0
CMS2_k127_88353_2 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000001384 207.0
CMS2_k127_88353_3 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000002506 164.0
CMS2_k127_88353_4 HEAT repeat - - - 0.000000000000000000000000000003683 132.0
CMS2_k127_88353_5 Histidine kinase - - - 0.000000000000000000001281 104.0
CMS2_k127_88353_6 His Kinase A (phosphoacceptor) domain - - - 0.000003371 57.0
CMS2_k127_88907_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 3.969e-287 895.0
CMS2_k127_88907_1 Belongs to the RtcB family K14415 - 6.5.1.3 2.207e-218 685.0
CMS2_k127_88907_10 Protein of unknown function (DUF3467) - - - 0.000000000000000000000000001082 116.0
CMS2_k127_88907_11 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000008354 116.0
CMS2_k127_88907_12 SMART Tetratricopeptide domain protein - - - 0.0000000000000001612 87.0
CMS2_k127_88907_13 Lrp/AsnC ligand binding domain - - - 0.00000000000001833 75.0
CMS2_k127_88907_14 PFAM NHL repeat containing protein - - - 0.00000001236 67.0
CMS2_k127_88907_2 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 2.984e-204 644.0
CMS2_k127_88907_3 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 540.0
CMS2_k127_88907_4 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 500.0
CMS2_k127_88907_5 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000169 269.0
CMS2_k127_88907_6 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001564 248.0
CMS2_k127_88907_7 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005564 249.0
CMS2_k127_88907_8 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000008943 175.0
CMS2_k127_88907_9 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000000000000000000000000000000003381 136.0
CMS2_k127_906834_0 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000004187 136.0
CMS2_k127_906834_1 acid phosphatase activity - - - 0.00000000000000001994 96.0
CMS2_k127_906834_2 DDE superfamily endonuclease - - - 0.0002031 44.0
CMS2_k127_927030_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 452.0
CMS2_k127_927030_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008763 398.0
CMS2_k127_927030_2 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 340.0
CMS2_k127_927030_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000004801 211.0
CMS2_k127_927030_4 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000001478 200.0
CMS2_k127_927030_5 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000000000000000000000000000000002142 188.0
CMS2_k127_927030_6 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.0000000000000000000000000000000000000007167 153.0
CMS2_k127_927030_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000009149 139.0
CMS2_k127_927030_8 Domains REC, PAS, PAS, PP2C K07315 - 3.1.3.3 0.0000000000000000001244 102.0
CMS2_k127_927030_9 Papain family cysteine protease - - - 0.0000009825 62.0
CMS2_k127_939996_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000002385 232.0
CMS2_k127_939996_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000007452 224.0
CMS2_k127_939996_2 pyridoxamine 5'-phosphate oxidase-related FMN-binding K07005 - - 0.0000000000000000003026 93.0
CMS2_k127_94591_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 7.268e-200 637.0
CMS2_k127_94591_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 605.0
CMS2_k127_94591_2 PFAM Binding-protein-dependent transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 441.0
CMS2_k127_94591_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000812 211.0
CMS2_k127_94591_4 Putative zinc- or iron-chelating domain K06940 - - 0.000000000009326 75.0
CMS2_k127_95572_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 458.0
CMS2_k127_95572_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000011 206.0
CMS2_k127_957439_0 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002796 269.0
CMS2_k127_957439_1 Subtilase family K01342,K13275,K13277 - 3.4.21.62 0.00000000000000000000000000000000000000000000000000000000000000001583 239.0
CMS2_k127_957439_2 Pfam Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000002479 138.0
CMS2_k127_957439_3 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.000000000000000000008899 95.0
CMS2_k127_967590_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 437.0
CMS2_k127_967590_1 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 396.0
CMS2_k127_967590_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003937 259.0
CMS2_k127_977901_0 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 583.0
CMS2_k127_977901_1 polysaccharide biosynthetic process - - - 0.000000000000001957 87.0