Involved in the biosynthesis of porphyrin-containing compound
-
-
-
0.00000000000000000868
86.0
DEZH1_k127_10033670_1
PFAM Radical SAM domain protein
K06871,K06941
-
2.1.1.192
0.00000000000001773
77.0
DEZH1_k127_10033670_2
Radical SAM domain protein
-
-
-
0.00000000002137
75.0
DEZH1_k127_10033670_3
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
0.00000001488
56.0
DEZH1_k127_10033670_4
asparagine
K01953
-
6.3.5.4
0.0008264
43.0
DEZH1_k127_10078386_0
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.00000000000000000000000000001607
119.0
DEZH1_k127_10078386_3
Dam-replacing family
-
-
-
0.0000000000000000000001775
97.0
DEZH1_k127_10078386_4
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.00000000004284
64.0
DEZH1_k127_1029646_19
Hep Hag repeat protein
-
-
-
0.00000000004471
68.0
DEZH1_k127_1029646_2
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.000000000414
61.0
DEZH1_k127_1029646_21
DNA polymerase III
K02341
-
2.7.7.7
0.000000000811
65.0
DEZH1_k127_1029646_22
Type II/IV secretion system protein
K02669
-
-
0.000000001537
63.0
DEZH1_k127_1029646_23
Beta-lactamase
K17836
-
3.5.2.6
0.0000000351
58.0
DEZH1_k127_1029646_24
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABC-type multidrug transport system, ATPase and permease components
K06148
-
-
0.000007112
48.0
DEZH1_k127_1029646_27
surface antigen
-
-
-
0.00001259
55.0
DEZH1_k127_1029646_29
hydrolase, TatD family
K03424
-
-
0.0005061
44.0
DEZH1_k127_1029646_3
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K00943
-
2.7.4.9
0.00000000000000000000000000000000000000000003484
168.0
DEZH1_k127_1029646_30
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0008264
43.0
DEZH1_k127_1029646_4
hydrolase, TatD family
K03424
-
-
0.000000000000000000000000000000000000000127
157.0
DEZH1_k127_1029646_5
type II secretion system protein
K02243,K02652
-
-
0.00000000000000000000000000000000000006687
147.0
DEZH1_k127_1029646_6
LemA family
K03744
-
-
0.0000000000000000000000000000000000002092
148.0
DEZH1_k127_1029646_7
ABC transporter
K06158
-
-
0.00000000000000000000000000000000002008
141.0
DEZH1_k127_1029646_8
COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454
-
-
0.00000000000000000000000000000000002363
138.0
DEZH1_k127_1029646_9
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
K03581
-
3.1.11.5
0.00000000005706
64.0
DEZH1_k127_10331028_3
secretion protein HlyD
K02005
-
-
0.0000000003318
73.0
DEZH1_k127_10331028_4
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K13888
-
-
0.000007485
59.0
DEZH1_k127_10359949_0
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K02952
-
-
0.0000000000000000000000000000000000002691
143.0
DEZH1_k127_10359949_1
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.0000000000001179
71.0
DEZH1_k127_10392012_0
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
K00067
-
1.1.1.133
0.0000000000000000000000000000006309
125.0
DEZH1_k127_10400706_5
Glycosyltransferases involved in cell wall biogenesis
-
-
-
0.00000000000000000000009521
103.0
DEZH1_k127_10400706_6
exonuclease
K07462
-
-
0.00000000000000002303
86.0
DEZH1_k127_10400706_7
involved in cell wall biogenesis
-
-
-
0.00000000000009751
73.0
DEZH1_k127_10400706_8
30S ribosomal protein S23
-
-
-
0.000000000004554
67.0
DEZH1_k127_10400706_9
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
K00067
-
1.1.1.133
0.000000002824
57.0
DEZH1_k127_1082912_0
Pfam Integrase core domain
-
-
-
0.0000000000000000536
81.0
DEZH1_k127_1082912_1
Helix-turn-helix domain
-
-
-
0.0000000000009678
74.0
DEZH1_k127_1082912_2
Helix-turn-helix domain
-
-
-
0.00000006228
54.0
DEZH1_k127_1222600_0
Fic/DOC family
-
-
-
0.00003554
49.0
DEZH1_k127_1222600_1
-
-
-
-
0.0005852
48.0
DEZH1_k127_1325573_0
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
K03282
-
-
0.00000000000000000000000000000000000001372
147.0
DEZH1_k127_1325573_1
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K01159
-
3.1.22.4
0.000000000000000000000000000000000006298
140.0
DEZH1_k127_1325573_10
PLD-like domain
-
-
-
0.0008175
45.0
DEZH1_k127_1325573_2
Belongs to the RNA methyltransferase TrmD family
K00554
-
2.1.1.228
0.000000000000000000001032
96.0
DEZH1_k127_1325573_3
Integrin alpha (beta-propellor repeats).
-
-
-
0.0000000000000000504
85.0
DEZH1_k127_1325573_4
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K02356
-
-
0.0000000000000000000000000000000000000005845
156.0
DEZH1_k127_1462162_10
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K18707
-
2.8.4.5
0.00000000000000003291
87.0
DEZH1_k127_1462162_11
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.0000000000000001436
82.0
DEZH1_k127_1462162_12
Type IV secretory pathway, VirB4
-
-
-
0.000000000000001337
85.0
DEZH1_k127_1462162_13
Sigma factor PP2C-like phosphatases
K07315
-
3.1.3.3
0.0000000000001127
81.0
DEZH1_k127_1462162_14
PFAM magnesium chelatase ChlI subunit
K07391
-
-
0.0000000000003085
69.0
DEZH1_k127_1462162_15
PFAM magnesium chelatase ChlI subunit
K07391
-
-
0.0000000000003621
69.0
DEZH1_k127_1462162_16
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
0.0000000000004853
79.0
DEZH1_k127_1462162_17
chelatase subunit ChlI
K07391
-
-
0.00000000002913
63.0
DEZH1_k127_1462162_18
Sigma factor PP2C-like phosphatases
K07315
-
3.1.3.3
0.0000000002122
66.0
DEZH1_k127_1462162_19
-
-
-
-
0.0000000006746
67.0
DEZH1_k127_1462162_2
helicase activity
-
-
-
0.000000000000000000000000000000000000001235
154.0
DEZH1_k127_1462162_20
Radical SAM methylthiotransferase, MiaB RimO family
K18707
-
2.8.4.5
0.000000003503
60.0
DEZH1_k127_1462162_21
COG COG3451 Type IV secretory pathway, VirB4 components
-
-
-
0.000000005706
59.0
DEZH1_k127_1462162_22
chelatase, subunit ChlI
K07391
-
-
0.00000001079
58.0
DEZH1_k127_1462162_23
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
K00384
-
1.8.1.9
0.00000001249
57.0
DEZH1_k127_1462162_24
TIGRFAM polysaccharide pyruvyl transferase CsaB
-
-
-
0.00000003922
61.0
DEZH1_k127_1462162_25
ErfK YbiS YcfS YnhG family protein
-
-
-
0.0000001062
55.0
DEZH1_k127_1462162_26
PFAM magnesium chelatase
K07391
-
-
0.0000001181
54.0
DEZH1_k127_1462162_27
diguanylate cyclase
-
-
-
0.0000001224
58.0
DEZH1_k127_1462162_28
chelatase subunit ChlI
K07391
-
-
0.0000001465
53.0
DEZH1_k127_1462162_29
PFAM magnesium chelatase
K07391
-
-
0.0000002018
53.0
DEZH1_k127_1462162_3
helicase activity
-
-
-
0.000000000000000000000000000000000000005488
153.0
DEZH1_k127_1462162_30
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.000000341
55.0
DEZH1_k127_1462162_31
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.000001046
53.0
DEZH1_k127_1462162_32
diguanylate cyclase
K02488
-
2.7.7.65
0.00000294
52.0
DEZH1_k127_1462162_33
O-Antigen ligase
-
-
-
0.000003484
53.0
DEZH1_k127_1462162_34
Belongs to the ompA family
K20276
-
-
0.000007244
58.0
DEZH1_k127_1462162_36
antibiotic catabolic process
-
-
-
0.0000441
51.0
DEZH1_k127_1462162_37
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072,K12257
-
-
0.00000000000000000000000000000000000001404
156.0
DEZH1_k127_1462162_40
Magnesium chelatase, subunit ChlI C-terminal
K07391
-
-
0.0003504
43.0
DEZH1_k127_1462162_41
Methyltransferase domain
-
-
-
0.0003547
46.0
DEZH1_k127_1462162_42
Thioredoxin reductase
K00384
-
1.8.1.9
0.0004827
43.0
DEZH1_k127_1462162_5
Type IV secretory pathway, VirB4
-
-
-
0.0000000000000000000000000000000000005005
146.0
DEZH1_k127_1462162_6
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
0.000000000211
61.0
DEZH1_k127_1740726_4
Belongs to the CDP-alcohol phosphatidyltransferase class-I family
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K03564
-
1.11.1.15
0.000000000000002197
76.0
DEZH1_k127_1911077_4
Domain of unknown function (DUF4145)
-
-
-
0.0000001104
57.0
DEZH1_k127_1911077_5
Redoxin
K03564
-
1.11.1.15
0.000000499
52.0
DEZH1_k127_1911077_6
Domain of unknown function (DUF4145)
-
-
-
0.000001495
49.0
DEZH1_k127_1911077_7
Domain of unknown function DUF11
-
-
-
0.000027
57.0
DEZH1_k127_1911077_8
Domain of unknown function (DUF4215)
-
-
-
0.000248
54.0
DEZH1_k127_1937070_0
Radical_SAM C-terminal domain
K07739
-
2.3.1.48
0.000000000000000000000000000000000000007754
151.0
DEZH1_k127_1937070_1
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.000000000000000000000000001052
115.0
DEZH1_k127_1937070_10
NUDIX domain
-
-
-
0.00000004857
57.0
DEZH1_k127_1937070_11
Binds directly to 16S ribosomal RNA
K02968
-
-
0.0000002535
56.0
DEZH1_k127_1937070_12
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0000002627
59.0
DEZH1_k127_1937070_13
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.000000784
53.0
DEZH1_k127_1937070_14
Belongs to the UPF0235 family
K09131
-
-
0.00002085
49.0
DEZH1_k127_1937070_15
DUF167
K09131
-
-
0.0003961
46.0
DEZH1_k127_1937070_2
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K02887
-
-
0.0000000000000000000000005566
108.0
DEZH1_k127_1937070_3
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0000000000000000004133
91.0
DEZH1_k127_1937070_4
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0000000000000001024
80.0
DEZH1_k127_1937070_5
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573,K12585
-
-
0.000000000000000635
85.0
DEZH1_k127_1937070_6
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)
Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K04564
-
1.15.1.1
0.00000000000000000000000000000000004844
135.0
DEZH1_k127_2147032_3
endonuclease containing a URI domain
K07461
-
-
0.000000000000000000002595
95.0
DEZH1_k127_2147032_4
PFAM RNP-1 like RNA-binding protein
-
-
-
0.00000000000000007389
84.0
DEZH1_k127_2147032_5
3-hydroxyisobutyrate dehydrogenase
K00020
-
1.1.1.31
0.000000000000002631
85.0
DEZH1_k127_2147032_6
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K01491
-
1.5.1.5,3.5.4.9
0.00000000000002527
73.0
DEZH1_k127_2147032_7
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K00806
-
2.5.1.31
0.0000000000001194
75.0
DEZH1_k127_2147032_8
SNARE associated Golgi protein
-
-
-
0.0000000000005257
75.0
DEZH1_k127_2147032_9
Belongs to the FPP GGPP synthase family
K13789
-
2.5.1.1,2.5.1.10,2.5.1.29
0.000000000001965
68.0
DEZH1_k127_2370228_0
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
0.00000000000000000001628
92.0
DEZH1_k127_2370228_11
S-layer homology domain
-
-
-
0.0000000000000000000281
96.0
DEZH1_k127_2370228_12
PFAM CutA1 divalent ion tolerance protein
K03926
-
-
0.000000000000001559
80.0
DEZH1_k127_2370228_13
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.000000000002177
68.0
DEZH1_k127_2370228_14
HD domain
K07023
-
-
0.00000000008988
68.0
DEZH1_k127_2370228_15
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10773
-
4.2.99.18
0.0000000005569
61.0
DEZH1_k127_2370228_16
SMART Metal-dependent phosphohydrolase, HD region
K07023
-
-
0.000004399
49.0
DEZH1_k127_2370228_17
domain protein
-
-
-
0.000007525
49.0
DEZH1_k127_2370228_18
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K02834
-
-
0.000008682
53.0
DEZH1_k127_2370228_19
Parallel beta-helix repeats
-
-
-
0.0007783
46.0
DEZH1_k127_2370228_2
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
K00940
-
2.7.4.6
0.000000000000000000000000000000000000000002786
160.0
DEZH1_k127_2370228_3
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
K01358
-
3.4.21.92
0.0000000000000000000000000000000000000002563
154.0
DEZH1_k127_2370228_4
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
0.0000000000000000000000000000000000244
141.0
DEZH1_k127_2370228_5
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10773
-
4.2.99.18
0.00000000000000000000000000000000307
133.0
DEZH1_k127_2370228_6
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
K01358
-
3.4.21.92
0.000000000000000000000000003709
111.0
DEZH1_k127_2370228_9
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.00000000000000000000003312
104.0
DEZH1_k127_2420312_0
Domain of unknown function (DUF4105)
-
-
-
0.0000000000000000000000000000000000002331
145.0
DEZH1_k127_2420312_1
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
K02935
-
-
0.00000000000000000000000000000002905
130.0
DEZH1_k127_2420312_2
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K02864
-
-
0.000000000000000006095
93.0
DEZH1_k127_2420312_3
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0
1097.0
DEZH1_k127_2965353_0
ABC transporter
-
-
-
0.00000000000000000000000000002954
127.0
DEZH1_k127_2965353_1
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.000000000000000000000000002472
115.0
DEZH1_k127_2965353_2
ABC transporter
K06158
-
-
0.00000000000000000000003837
103.0
DEZH1_k127_2965353_3
Pyridine nucleotide-disulphide oxidoreductase
K05297
-
1.18.1.1
0.000000000000000000001864
94.0
DEZH1_k127_2965353_4
endonuclease containing a URI domain
K07461
-
-
0.0000000001533
62.0
DEZH1_k127_2965353_5
endonuclease containing a URI domain
K07461
-
-
0.0000000004921
60.0
DEZH1_k127_2965353_6
Oxidoreductase NAD-binding domain
K02613
-
-
0.000000001061
64.0
DEZH1_k127_2965353_7
ABC transporter, ATP-binding protein
K06158
-
-
0.00000005122
56.0
DEZH1_k127_2965353_8
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.00000006143
59.0
DEZH1_k127_3022033_0
-
-
-
-
0.0000000000000000000000000000000000002183
147.0
DEZH1_k127_3022033_1
Possible lysine decarboxylase
K06966
-
3.2.2.10
0.0000000000000000000000001151
108.0
DEZH1_k127_3022033_2
Belongs to the LOG family
K06966
-
3.2.2.10
0.0000008881
55.0
DEZH1_k127_3022033_3
Belongs to the LOG family
K06966
-
3.2.2.10
0.0001147
45.0
DEZH1_k127_302433_0
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03470
-
3.1.26.4
0.0000000000000000000001675
99.0
DEZH1_k127_302433_2
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
0.000002823
52.0
DEZH1_k127_302433_3
PFAM Single-stranded nucleic acid binding R3H
K06346
-
-
0.000006589
54.0
DEZH1_k127_302433_5
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03470
-
3.1.26.4
0.0000184
51.0
DEZH1_k127_302433_6
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03470
-
3.1.26.4
0.0002405
44.0
DEZH1_k127_3137039_0
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K01489,K07042
-
3.5.4.5
0.00000000000000000000001523
103.0
DEZH1_k127_3137039_1
Belongs to the cysteine synthase cystathionine beta- synthase family
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.000000000000000000000002512
112.0
DEZH1_k127_3272739_2
COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
0.00004337
46.0
DEZH1_k127_3405301_2
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
K01749
-
2.5.1.61
0.0000000000000000000000000000000000001453
146.0
DEZH1_k127_3405301_3
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
0.0000000000000000000000000000000004662
131.0
DEZH1_k127_3405301_4
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
K01749
-
2.5.1.61
0.000000000000000000000000000002501
124.0
DEZH1_k127_3405301_5
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.000000000000000000000000006322
113.0
DEZH1_k127_3405301_6
-
-
-
-
0.0000000000000000000000003371
108.0
DEZH1_k127_3405301_7
Uroporphyrinogen decarboxylase (URO-D)
K01599
-
4.1.1.37
0.00000000000000000001387
91.0
DEZH1_k127_3405301_8
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
K01749
-
2.5.1.61
0.00000000000000001139
85.0
DEZH1_k127_3405301_9
Uroporphyrinogen-III synthase
K01719
-
4.2.1.75
0.000000002863
61.0
DEZH1_k127_3539453_0
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K03625
-
-
0.0000003572
56.0
DEZH1_k127_3585469_12
general secretion pathway protein
K02456,K02650
-
-
0.0004605
44.0
DEZH1_k127_3585469_13
PIF1-like helicase
-
-
-
0.0005221
45.0
DEZH1_k127_3585469_2
TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0000000000000000000021
96.0
DEZH1_k127_3716245_2
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.00000000000000116
79.0
DEZH1_k127_3716245_3
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0002943
51.0
DEZH1_k127_3765635_0
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.00000000000000000000000000000000131
132.0
DEZH1_k127_3765635_1
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.0000001012
56.0
DEZH1_k127_3776141_11
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.0000001375
53.0
DEZH1_k127_3776141_12
resolvase
-
-
-
0.000001716
55.0
DEZH1_k127_3776141_13
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.000009161
49.0
DEZH1_k127_3776141_14
Putative diguanylate phosphodiesterase
-
-
-
0.000009607
47.0
DEZH1_k127_3776141_15
FMN_bind
-
-
-
0.00004392
51.0
DEZH1_k127_3776141_16
FMN_bind
-
-
-
0.00006204
50.0
DEZH1_k127_3776141_17
tail collar domain protein
K21449
-
-
0.0001766
51.0
DEZH1_k127_3776141_2
SMART Diguanylate phosphodiesterase
-
-
-
0.000000000000000000000000000000000000000009191
157.0
DEZH1_k127_3776141_3
Diguanylate cyclase
-
-
-
0.0000000000000000000000000000006389
128.0
DEZH1_k127_3776141_4
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.000000000000000000000001386
106.0
DEZH1_k127_3776141_5
Catalyzes the ferrous insertion into protoporphyrin IX
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.0000000000003594
73.0
DEZH1_k127_3776141_8
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.0000000001312
62.0
DEZH1_k127_3776141_9
CHASE
-
-
-
0.000000005857
58.0
DEZH1_k127_4203866_0
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
K03664
-
-
0.0000000000000000000000000000188
121.0
DEZH1_k127_4203866_4
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
-
-
-
0.00000000000000000000007355
109.0
DEZH1_k127_4203866_5
UPF0489 domain
-
-
-
0.00000000000000000758
87.0
DEZH1_k127_4203866_6
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
0.0000000000000000000000000000000000002669
147.0
DEZH1_k127_4257265_1
Provides the (R)-glutamate required for cell wall biosynthesis
K01776
-
5.1.1.3
0.00000000000000000000000002763
113.0
DEZH1_k127_4257265_2
Provides the (R)-glutamate required for cell wall biosynthesis
K01776
-
5.1.1.3
0.0000000489
56.0
DEZH1_k127_4276472_0
Psort location CytoplasmicMembrane, score
K09812
-
-
0.0000000000000000000000000005395
114.0
DEZH1_k127_4276472_1
cell division ATP-binding protein FtsE
K09812
-
-
0.0000000000000000000000000007006
115.0
DEZH1_k127_4276472_2
Insecticidal toxin complex protein TcaC
-
-
-
0.00000005923
55.0
DEZH1_k127_4276472_5
TIGRFAM RHS repeat-associated core domain
-
-
-
0.0001032
45.0
DEZH1_k127_4285703_0
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K03648
-
3.2.2.27
0.0000000000000000000000000000000000000000004656
160.0
DEZH1_k127_4285703_1
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K03648
-
3.2.2.27
0.000000000000000000001225
94.0
DEZH1_k127_4285703_2
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
0.000000002753
65.0
DEZH1_k127_4523254_11
polyphosphate kinase
K22468
-
2.7.4.1
0.00000001639
62.0
DEZH1_k127_4523254_12
Psort location Cytoplasmic, score 8.87
K07007
-
-
0.0006651
43.0
DEZH1_k127_4523254_2
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
K07642
-
2.7.13.3
0.000000000000000000000000002065
121.0
DEZH1_k127_4523254_3
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885,K09698
-
6.1.1.17,6.1.1.24
0.00000000000000000000002447
106.0
DEZH1_k127_4523254_4
TIGRFAM flavoprotein, HI0933 family
K07007
-
-
0.0000000000000000000002765
97.0
DEZH1_k127_4523254_5
rubredoxin
-
-
-
0.0000000000000000000006807
98.0
DEZH1_k127_4523254_6
Oxidoreductase FAD-binding domain
K05784,K16161
-
1.14.13.25
0.0000000000009099
74.0
DEZH1_k127_4523254_7
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885,K09698
-
6.1.1.17,6.1.1.24
0.00000000005611
63.0
DEZH1_k127_4523254_8
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K17247
-
-
0.0000000001048
70.0
DEZH1_k127_4523254_9
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
0.0000000004652
61.0
DEZH1_k127_4527500_0
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K02871
-
-
0.00000000000000000000000000000000000000339
151.0
DEZH1_k127_4527500_3
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
K02992
-
-
0.0000000000000000000000000000000000006732
144.0
DEZH1_k127_4527500_4
Belongs to the universal ribosomal protein uS9 family
K02996
-
-
0.0000000000000000000000000001121
119.0
DEZH1_k127_4527500_5
Belongs to the bacterial ribosomal protein bL27 family
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K03625
-
-
0.00000004609
59.0
DEZH1_k127_4527500_7
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
transferase activity, transferring glycosyl groups
-
-
-
0.00000000000000000007624
96.0
DEZH1_k127_4789743_1
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K00567,K10778
-
2.1.1.63
0.00000000000000001112
82.0
DEZH1_k127_4789743_2
Protein of unknown function (DUF1800)
-
-
-
0.000000000000002821
91.0
DEZH1_k127_4789743_3
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K00567
-
2.1.1.63
0.000000000001977
67.0
DEZH1_k127_4789743_4
Protein of unknown function (DUF1501)
-
-
-
0.00001113
57.0
DEZH1_k127_4789743_5
Protein of unknown function (DUF1501)
-
-
-
0.0001746
55.0
DEZH1_k127_480306_0
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K02965
-
-
0.000000000000000000000000000000003118
129.0
DEZH1_k127_480306_14
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K02890
-
-
0.0000000000000000000007736
98.0
DEZH1_k127_480306_2
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.0000000000004866
72.0
DEZH1_k127_480306_29
5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
-
-
-
0.000000005257
60.0
DEZH1_k127_480306_3
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.0000003267
55.0
DEZH1_k127_480306_32
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.00000000000000001963
93.0
DEZH1_k127_4869466_15
Sodium:solute symporter family
-
-
-
0.0000000000002116
70.0
DEZH1_k127_4869466_16
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K03701
-
-
0.0000001122
54.0
DEZH1_k127_5074101_12
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.000005071
50.0
DEZH1_k127_5074101_13
Belongs to the peptidase S8 family
K01361
-
3.4.21.96
0.0006466
48.0
DEZH1_k127_5074101_2
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.00000000000000000000000000000002725
126.0
DEZH1_k127_5074101_3
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K03701
-
-
0.000000000000000000000000001555
116.0
DEZH1_k127_5074101_4
Belongs to the peptidase S8 family
-
-
-
0.00000000000000000000000001176
114.0
DEZH1_k127_5074101_5
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.00000000000000000000000002864
108.0
DEZH1_k127_5074101_6
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.000000000000000000001783
93.0
DEZH1_k127_5074101_7
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09765
-
1.17.99.6
0.000000000000000000000000002261
113.0
DEZH1_k127_5174488_3
queuosine biosynthetic process
K03470,K09765
-
1.17.99.6,3.1.26.4
0.000000000003055
72.0
DEZH1_k127_5174488_4
Produces ATP from ADP in the presence of a proton gradient across the membrane
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530
-
-
0.00000000000000000003524
96.0
DEZH1_k127_5187808_11
DNA polymerase III
K02337
-
2.7.7.7
0.000000000000003438
78.0
DEZH1_k127_5187808_12
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
0.000000003673
57.0
DEZH1_k127_5187808_17
aminopeptidase activity
-
-
-
0.00000000442
66.0
DEZH1_k127_5187808_18
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.00000001312
58.0
DEZH1_k127_5187808_19
DNA polymerase
K02337,K14162
-
2.7.7.7
0.0000002186
59.0
DEZH1_k127_5187808_2
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
0.000005682
48.0
DEZH1_k127_5187808_21
Mechanosensitive ion channel
K16052
-
-
0.0001674
47.0
DEZH1_k127_5187808_22
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03086
-
-
0.0004217
42.0
DEZH1_k127_5187808_3
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.000000000000000000000000000000000000000001867
170.0
DEZH1_k127_5187808_4
Extradiol ring-cleavage dioxygenase
K15777
-
-
0.0000000000000000000000000000000000000001737
156.0
DEZH1_k127_5187808_5
DNA polymerase III, alpha subunit
K02337,K14162
-
2.7.7.7
0.0000000000000000000000000000000000000002876
161.0
DEZH1_k127_5187808_6
aminopeptidase activity
-
-
-
0.000000000000000000000000000003966
124.0
DEZH1_k127_5187808_7
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0000000000000000000000000001468
115.0
DEZH1_k127_5187808_8
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0000000000000000000000000000000000000305
149.0
DEZH1_k127_5381580_10
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.00000000000000177
85.0
DEZH1_k127_5381580_11
PFAM Xylose isomerase domain-containing protein TIM barrel
Endonuclease related to archaeal Holliday junction resolvase
-
-
-
0.0000006168
54.0
DEZH1_k127_5381580_17
COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase
-
-
-
0.0005692
43.0
DEZH1_k127_5381580_18
Protein of unknown function (DUF1294)
-
-
-
0.0009163
43.0
DEZH1_k127_5381580_2
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0000000000000000005458
93.0
DEZH1_k127_5381580_8
ATP-dependent DNA helicase
K03657
-
3.6.4.12
0.00000000000000003821
83.0
DEZH1_k127_5381580_9
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
-
-
-
0.000000000000000000001534
97.0
DEZH1_k127_5477629_4
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
-
-
-
0.000000000000000006517
87.0
DEZH1_k127_5574204_0
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
2.257e-270
849.0
DEZH1_k127_5574204_1
S-layer homology domain
-
-
-
0.000002669
56.0
DEZH1_k127_562881_0
Peptidase family M48
-
-
-
0.00000000000000000000000000003598
121.0
DEZH1_k127_562881_1
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.00000000000000000000001015
111.0
DEZH1_k127_562881_10
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.0001658
50.0
DEZH1_k127_562881_11
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
0.0004571
53.0
DEZH1_k127_562881_12
COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase
-
-
-
0.0005692
43.0
DEZH1_k127_562881_13
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.0007585
46.0
DEZH1_k127_562881_2
Belongs to the peptidase M48B family
K03799
-
-
0.000000000000002503
78.0
DEZH1_k127_562881_3
Belongs to the peptidase M48B family
K03799
-
-
0.00000000001564
65.0
DEZH1_k127_562881_4
Belongs to the N-Me-Phe pilin family
K02650,K02655
-
-
0.00000003227
61.0
DEZH1_k127_562881_5
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.00000003778
56.0
DEZH1_k127_562881_6
Endonuclease related to archaeal Holliday junction resolvase
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.00007138
47.0
DEZH1_k127_5636226_0
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.00000000000000000000000000000000338
132.0
DEZH1_k127_5757446_0
ATPase (AAA
-
-
-
0.0000000000000000000000000000000000002925
142.0
DEZH1_k127_5757446_1
AAA ATPase
-
-
-
0.0000000000000000000000000000000000007334
140.0
DEZH1_k127_5757446_10
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
0.000005307
51.0
DEZH1_k127_5757446_11
4Fe-4S single cluster domain of Ferredoxin I
-
-
-
0.0000543
48.0
DEZH1_k127_5757446_12
Cell cycle protein
K03588
-
-
0.0007487
45.0
DEZH1_k127_5757446_13
Phosphodiester glycosidase
-
-
-
0.0008835
45.0
DEZH1_k127_5757446_2
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
0.000000000000000003681
85.0
DEZH1_k127_5757446_3
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Two component transcriptional regulator, LuxR family
-
-
-
0.00000000000000000000000000002048
122.0
DEZH1_k127_5946431_2
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.00001474
53.0
DEZH1_k127_5987486_0
Lumazine binding domain
K00793
-
2.5.1.9
0.0000000000000000000000000000000000177
139.0
DEZH1_k127_5987486_1
COG0477 Permeases of the major facilitator superfamily
-
-
-
0.000001364
57.0
DEZH1_k127_6031538_0
TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain
K01905,K22224
-
6.2.1.13
0.0000000000000000002776
91.0
DEZH1_k127_6031538_1
CoA binding domain
-
-
-
0.00003922
47.0
DEZH1_k127_6052921_0
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Belongs to the mannose-6-phosphate isomerase type 2 family
K00971
-
2.7.7.13
0.00000000000000000000000000000000000214
143.0
DEZH1_k127_61244_1
Belongs to the glycosyltransferase 26 family
K05946
-
2.4.1.187
0.0000000000001242
78.0
DEZH1_k127_61244_2
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
K05946
-
2.4.1.187
0.000002679
51.0
DEZH1_k127_61244_3
ADP-L-glycero-beta-D-manno-heptose biosynthetic process
helix_turn_helix, arabinose operon control protein
-
-
-
0.00000001601
61.0
DEZH1_k127_6130576_17
PFAM PKD domain containing protein
-
-
-
0.00000002161
57.0
DEZH1_k127_6130576_18
NUDIX domain
K03574
-
3.6.1.55
0.00000005475
61.0
DEZH1_k127_6130576_19
lactoylglutathione lyase activity
-
-
-
0.0000004663
51.0
DEZH1_k127_6130576_2
SNARE associated Golgi protein
-
-
-
0.0000000000000000000000000000000000001249
147.0
DEZH1_k127_6130576_20
-
-
-
-
0.000001204
51.0
DEZH1_k127_6130576_21
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K02563
-
2.4.1.227
0.000001858
51.0
DEZH1_k127_6130576_22
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
0.0000102
49.0
DEZH1_k127_6130576_23
Addiction module toxin RelE StbE family
-
-
-
0.00001045
51.0
DEZH1_k127_6130576_24
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
0.00000000000000000000003872
106.0
DEZH1_k127_6153160_1
Belongs to the D-alanine--D-alanine ligase family
K01921
-
6.3.2.4
0.00000000001318
67.0
DEZH1_k127_6153160_2
Belongs to the D-alanine--D-alanine ligase family
K01921
-
6.3.2.4
0.0000001271
55.0
DEZH1_k127_6153160_3
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
0.000001283
56.0
DEZH1_k127_6153160_4
Belongs to the D-alanine--D-alanine ligase family
K01921
-
6.3.2.4
0.000001696
50.0
DEZH1_k127_6153160_5
-
-
-
-
0.00002173
48.0
DEZH1_k127_6153160_6
Endonuclease/Exonuclease/phosphatase family
-
-
-
0.00002454
50.0
DEZH1_k127_6153160_7
Belongs to the D-alanine--D-alanine ligase family
K01921
-
6.3.2.4
0.0001975
48.0
DEZH1_k127_6166433_0
Alpha-2-Macroglobulin
K06894
-
-
0.0000000000000009176
82.0
DEZH1_k127_6166433_1
Alpha-2-Macroglobulin
K06894
-
-
0.0000000003705
66.0
DEZH1_k127_6166433_2
Large extracellular alpha-helical protein
K06894
-
-
0.0000005342
57.0
DEZH1_k127_6166433_3
Alpha-2-macroglobulin family
K06894
-
-
0.00003401
48.0
DEZH1_k127_6166433_4
TonB-dependent Receptor Plug Domain
-
-
-
0.0005852
48.0
DEZH1_k127_6353684_0
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Participates in transcription elongation, termination and antitermination
K02601
-
-
0.000000000000000000000000000000000000000000673
162.0
DEZH1_k127_6533519_3
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.000000000001275
67.0
DEZH1_k127_6640207_4
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.00000000006931
63.0
DEZH1_k127_6640207_5
PFAM ComEC Rec2-related protein
K02238
-
-
0.000001215
54.0
DEZH1_k127_6640207_6
DNA internalization competence protein ComEC Rec2-like protein
K02238
-
-
0.00001316
53.0
DEZH1_k127_6640207_7
gamma-glutamyltransferase
K00681
-
2.3.2.2,3.4.19.13
0.0001482
51.0
DEZH1_k127_6640207_8
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Type I restriction enzyme R protein N terminus (HSDR_N)
K03427
-
2.1.1.72
0.00000000000000000000000000000000000008005
143.0
DEZH1_k127_6705241_10
restriction
K01154
-
3.1.21.3
0.000000007043
57.0
DEZH1_k127_6705241_11
restriction
K01154
-
3.1.21.3
0.00001681
48.0
DEZH1_k127_6705241_12
N-6 DNA methylase
K03427
-
2.1.1.72
0.00005127
46.0
DEZH1_k127_6705241_13
Type I restriction modification DNA specificity domain
K01154
-
3.1.21.3
0.0005809
42.0
DEZH1_k127_6705241_2
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0000000000000000000000000000000000004862
150.0
DEZH1_k127_6705241_3
N-6 DNA Methylase
-
-
-
0.00000000000000000000000000000000003861
136.0
DEZH1_k127_6705241_4
restriction
K01154
-
3.1.21.3
0.00000000000000000000000000000009138
127.0
DEZH1_k127_6705241_5
N-6 DNA Methylase
K03427
-
2.1.1.72
0.000000000000000000000000002168
112.0
DEZH1_k127_6705241_6
restriction
K01154
-
3.1.21.3
0.00000000000000000000001366
102.0
DEZH1_k127_6705241_7
type I restriction modification DNA specificity domain
K01154
-
3.1.21.3
0.0000000003412
61.0
DEZH1_k127_6705241_8
restriction
K01154
-
3.1.21.3
0.0000000004252
62.0
DEZH1_k127_6705241_9
N-6 DNA Methylase
-
-
-
0.000000005044
58.0
DEZH1_k127_6854276_0
Oxidoreductase NAD-binding domain protein
K00523
-
1.17.1.1
0.000000000385
69.0
DEZH1_k127_6854276_1
TraB family
K09973
-
-
0.00000001373
64.0
DEZH1_k127_6939956_0
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.0000000000000000006405
91.0
DEZH1_k127_6939956_11
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695,K03696
-
-
0.0000000000000003467
78.0
DEZH1_k127_6939956_12
Transcriptional regulatory protein, C terminal
-
-
-
0.0000000000000004199
79.0
DEZH1_k127_6939956_13
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.0000000000000007555
79.0
DEZH1_k127_6939956_14
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.0000000000001549
73.0
DEZH1_k127_6939956_15
Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.0000007482
53.0
DEZH1_k127_6939956_23
Transcriptional regulator
K10947
-
-
0.000002438
49.0
DEZH1_k127_6939956_24
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.000009229
49.0
DEZH1_k127_7181870_13
Methicillin resistance protein
-
-
-
0.0001945
46.0
DEZH1_k127_7181870_14
pfam nudix
-
-
-
0.0007936
44.0
DEZH1_k127_7181870_15
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.0008665
48.0
DEZH1_k127_7181870_2
pfam nudix
-
-
-
0.000000000000000000222
92.0
DEZH1_k127_7181870_3
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Type IV minor pilin ComP, DNA uptake sequence receptor
K02655
-
-
0.000000007994
61.0
DEZH1_k127_7181870_9
Methicillin resistance protein
-
-
-
0.000000009502
60.0
DEZH1_k127_7211222_0
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K07738
-
-
0.0000000000000000000000000000000001517
138.0
DEZH1_k127_7211222_3
BRO family, N-terminal domain
-
-
-
0.000000000000000000000000000000006481
128.0
DEZH1_k127_7211222_4
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000000517
96.0
DEZH1_k127_7211222_5
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
K01056
-
3.1.1.29
0.0000000000000000000000000000001797
126.0
DEZH1_k127_7311961_2
Hemolysin
K06442
-
2.1.1.226,2.1.1.227
0.000000000000000005159
84.0
DEZH1_k127_7311961_3
-
-
-
-
0.00000000008395
68.0
DEZH1_k127_7311961_4
rRNA methylase
K06442
-
2.1.1.226,2.1.1.227
0.0000000001393
64.0
DEZH1_k127_7311961_5
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
K01056
-
3.1.1.29
0.0000000004463
62.0
DEZH1_k127_7311961_6
Belongs to the glycosyl hydrolase 28 family
-
-
-
0.000000006327
59.0
DEZH1_k127_7311961_7
Type II/IV secretion system protein
K02669
-
-
0.000001129
53.0
DEZH1_k127_7311961_8
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.000002107
52.0
DEZH1_k127_7311961_9
domain, Protein
K01729,K03561,K09942,K12287,K20276
-
4.2.2.3
0.00001003
50.0
DEZH1_k127_7355823_0
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Catalyzes the reversible phosphorylation of UMP to UDP
K09903
-
2.7.4.22
0.00000000000000000000000587
103.0
DEZH1_k127_7355823_13
ABC-type multidrug transport system ATPase and permease
K06147
-
-
0.00000000000000000000005511
99.0
DEZH1_k127_7355823_14
ABC transporter, transmembrane region
K06147
-
-
0.0000000000000000000001995
97.0
DEZH1_k127_7355823_15
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0000000000000000004639
92.0
DEZH1_k127_7355823_17
Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K13292
-
-
0.0000000000000000753
83.0
DEZH1_k127_7355823_18
Belongs to the class-I aminoacyl-tRNA synthetase family
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
K02236,K02654
-
3.4.23.43
0.00000001766
57.0
DEZH1_k127_7355823_32
PFAM Peptidase family M23
-
-
-
0.0000001069
61.0
DEZH1_k127_7355823_34
Archaeal Type IV pilin, N-terminal
-
-
-
0.0000001387
64.0
DEZH1_k127_7355823_36
ABC transporter, transmembrane region
K06147
-
-
0.0000003789
51.0
DEZH1_k127_7355823_37
Capsular polysaccharide biosynthesis protein
K20997
-
-
0.000007993
53.0
DEZH1_k127_7355823_38
Bacterial Peptidase A24 N-terminal domain
K02654
-
3.4.23.43
0.00001206
47.0
DEZH1_k127_7355823_39
peptidase
-
-
-
0.00002668
51.0
DEZH1_k127_7355823_4
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.00007475
49.0
DEZH1_k127_7355823_41
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.00007475
49.0
DEZH1_k127_7355823_42
Belongs to the peptidase S8 family
K14645
-
-
0.00008874
46.0
DEZH1_k127_7355823_43
Purple acid Phosphatase, N-terminal domain
-
-
-
0.00009145
53.0
DEZH1_k127_7355823_44
CYTH domain
K05873
-
4.6.1.1
0.0002127
46.0
DEZH1_k127_7355823_45
NlpC/P60 family
K21472
-
-
0.0003087
50.0
DEZH1_k127_7355823_46
S-layer domain protein
K01181
-
3.2.1.8
0.0003847
46.0
DEZH1_k127_7355823_47
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.0005206
47.0
DEZH1_k127_7355823_5
ABC transporter transmembrane region
K06147
-
-
0.000000000000000000000000000000000000000001107
159.0
DEZH1_k127_7355823_6
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.00000000000000000000000000000000000005097
146.0
DEZH1_k127_7355823_7
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.00000000000000000000000000000000003169
136.0
DEZH1_k127_7355823_8
Catalyzes the reversible phosphorylation of UMP to UDP
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ABC-type transport system involved in multi-copper enzyme maturation, permease component
-
-
-
0.0000000000005259
76.0
DEZH1_k127_8065565_16
Type II restriction endonuclease EcoO109I
-
-
-
0.00000000000232
67.0
DEZH1_k127_8065565_17
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K00783
-
2.1.1.177
0.0000000007844
62.0
DEZH1_k127_8065565_18
protein histidine kinase activity
-
-
-
0.000001094
59.0
DEZH1_k127_8065565_19
CBS domain containing protein
-
-
-
0.00005907
49.0
DEZH1_k127_8065565_2
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
-
-
-
0.0000000000000000000000006282
111.0
DEZH1_k127_8168596_3
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
0.000000000000000000148
91.0
DEZH1_k127_8168596_5
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
K01462
-
3.5.1.88
0.00000000002386
69.0
DEZH1_k127_8168596_6
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
K01462
-
3.5.1.88
0.00000000006764
64.0
DEZH1_k127_8168596_7
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05540
-
-
0.000002104
50.0
DEZH1_k127_8168596_8
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
0.0003166
44.0
DEZH1_k127_8212241_0
feS assembly protein SufB
K07033,K09014
-
-
0.000000000000000000000000000000000007079
137.0
DEZH1_k127_8212241_1
TIGRFAM FeS assembly ATPase SufC
K09013
-
-
0.00000000000000000000001288
106.0
DEZH1_k127_8212241_2
FeS assembly ATPase SUFC
K09013
-
-
0.00000000000000000002021
93.0
DEZH1_k127_8212241_3
ABC-type transport system involved in Fe-S cluster assembly, permease component
K09014
-
-
0.0000000000000002395
79.0
DEZH1_k127_8212241_4
assembly protein SufB
K07033,K09014
-
-
0.00000000004885
65.0
DEZH1_k127_8212241_5
PFAM Excinuclease ABC, C subunit domain protein
K07461
-
-
0.0000001036
53.0
DEZH1_k127_8212241_6
GIY-YIG catalytic domain
K07461
-
-
0.000006013
48.0
DEZH1_k127_8274929_0
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000000000000005709
85.0
DEZH1_k127_8274929_12
Thioredoxin
-
-
-
0.000000000000000178
89.0
DEZH1_k127_8274929_13
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567,K04568
-
6.1.1.6
0.00000000000001812
74.0
DEZH1_k127_8274929_14
PFAM tRNA synthetases class II (D, K and N)
K04567
-
6.1.1.6
0.0000000003034
68.0
DEZH1_k127_8274929_15
methylamine metabolic process
K03885,K15977
-
1.6.99.3
0.0000000003726
66.0
DEZH1_k127_8274929_16
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0000000006729
66.0
DEZH1_k127_8274929_17
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000002041
57.0
DEZH1_k127_8274929_18
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000003488
55.0
DEZH1_k127_8274929_19
Peptidase family M48
-
-
-
0.0002103
45.0
DEZH1_k127_8274929_2
Belongs to the class-II aminoacyl-tRNA synthetase family
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.00000002919
59.0
DEZH1_k127_8679847_14
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.00000000000001837
80.0
DEZH1_k127_8679847_8
Phosphoglucomutase phosphomannomutase alpha beta alpha domain I
K00966,K03273,K15669,K16881
-
2.7.7.13,2.7.7.71,3.1.3.82,3.1.3.83,5.4.2.8
0.0000000000002415
73.0
DEZH1_k127_8679847_9
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K02115
-
-
0.00000000001197
68.0
DEZH1_k127_8683668_0
calcium- and calmodulin-responsive adenylate cyclase activity
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Reverse transcriptase (RNA-dependent DNA polymerase)
-
-
-
0.000000000002437
67.0
DEZH1_k127_8810460_0
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
0.000000000000000000000000000000000000002671
152.0
DEZH1_k127_8810460_1
histidyl-tRNA synthetase
K01892
-
6.1.1.21
0.00000000000000000000000003489
111.0
DEZH1_k127_8810460_2
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
ATPase family associated with various cellular activities
K03924
-
-
0.0000000000000017
76.0
DEZH1_k127_8828110_11
Integral membrane protein TerC family
-
-
-
0.00000000000003423
73.0
DEZH1_k127_8828110_12
Protein of unknown function (DUF465)
K09794
-
-
0.000000000001713
70.0
DEZH1_k127_8828110_13
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.000000000000000000000000000000000000000001194
160.0
DEZH1_k127_8828110_3
ATPase family associated with various cellular activities (AAA)
K03924
-
-
0.0000000000000000000000000000000000007974
144.0
DEZH1_k127_8828110_4
Multicopper oxidase
-
-
-
0.000000000000000000000000000000003525
129.0
DEZH1_k127_8828110_5
Malate dehydrogenase
K00027
-
1.1.1.38
0.00000000000000000000000000144
111.0
DEZH1_k127_8828110_6
ATPase family associated with various cellular activities (AAA)
K03924
-
-
0.0000000000000000000001071
97.0
DEZH1_k127_8828110_7
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.00000000000000000007956
90.0
DEZH1_k127_8828110_8
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.0000000000000000004338
87.0
DEZH1_k127_8828110_9
Integral membrane protein TerC family
-
-
-
0.000000000000000004397
86.0
DEZH1_k127_8931129_0
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
0.000000000000000000000000000000001345
134.0
DEZH1_k127_8931129_2
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0000000000000000001321
94.0
DEZH1_k127_8931129_3
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
0.0000000000000001375
81.0
DEZH1_k127_8931129_4
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
0.00000000000002943
76.0
DEZH1_k127_8931129_5
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.00000005827
63.0
DEZH1_k127_8937427_0
Glycosyltransferase WbsX
-
-
-
0.000000000000000000000000000001996
126.0
DEZH1_k127_8937427_1
Glycosyl Transferase
-
-
-
0.000000000000000000000000005161
114.0
DEZH1_k127_8937427_2
glycosyl transferase group 1
-
-
-
0.00000000000000000003841
94.0
DEZH1_k127_8937427_3
Glycosyltransferase like family 2
-
-
-
0.00000000000001394
76.0
DEZH1_k127_8937427_4
Glycosyltransferase WbsX
-
-
-
0.000000000000101
71.0
DEZH1_k127_8937427_5
glycosyl transferase group 1
-
-
-
0.00000000003329
65.0
DEZH1_k127_8937427_6
Glycosyltransferase like family 2
-
-
-
0.00000005841
56.0
DEZH1_k127_8937427_7
Glycosyl transferase family 2
-
-
-
0.00003299
53.0
DEZH1_k127_8937427_8
Glycosyltransferase like family 2
-
-
-
0.0009594
44.0
DEZH1_k127_8943891_0
Type IV pilus biogenesis protein
K02655
-
-
0.00000000001343
72.0
DEZH1_k127_9080264_0
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.000000000000000000000000000000000007733
143.0
DEZH1_k127_9080264_4
Involved in the binding of tRNA to the ribosomes
K02946
-
-
0.000000000000000000000000000009562
121.0
DEZH1_k127_9080264_5
Beta propeller domain
-
-
-
0.00000000000000000000004356
104.0
DEZH1_k127_9080264_6
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0000000000000000000008156
97.0
DEZH1_k127_9080264_7
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0000000004979
63.0
DEZH1_k127_9083411_0
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp
K01876
-
6.1.1.12
0.000000000000000000000000007703
111.0
DEZH1_k127_9083411_2
Belongs to the NqrB RnfD family
-
-
-
0.0000000006137
61.0
DEZH1_k127_9083411_3
EamA-like transporter family
-
-
-
0.00005038
53.0
DEZH1_k127_9084628_0
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
0.00000000000000000000000000000003354
131.0
DEZH1_k127_9084628_12
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K02897
-
-
0.000000000000000000000000000003695
127.0
DEZH1_k127_9084628_13
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.000000000000000162
81.0
DEZH1_k127_9084628_14
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.000000001774
59.0
DEZH1_k127_9084628_17
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K09747
-
-
0.00000002012
59.0
DEZH1_k127_9084628_18
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.00000004086
57.0
DEZH1_k127_9084628_19
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COG2931, RTX toxins and related Ca2 -binding proteins
-
-
-
0.00001639
54.0
DEZH1_k127_9084628_26
helicase involved in DNA repair and perhaps also replication
K02342,K03722
-
2.7.7.7,3.6.4.12
0.0001259
48.0
DEZH1_k127_9084628_27
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.0002543
44.0
DEZH1_k127_9084628_28
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.00000000000000000000000000000000000002265
147.0
DEZH1_k127_9084628_7
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
0.00000000000000000000000000000000000008654
151.0
DEZH1_k127_9084628_8
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K03215
-
2.1.1.190
0.0000000000000003587
82.0
DEZH1_k127_9339764_2
Psort location CytoplasmicMembrane, score 9.82
K03748
-
-
0.000000000000002219
76.0
DEZH1_k127_9339764_3
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K03215
-
2.1.1.190
0.0000000002756
63.0
DEZH1_k127_9339764_7
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
-
-
-
0.000000007106
60.0
DEZH1_k127_9339764_8
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.00000000000000000000000000000000000000001104
156.0
DEZH1_k127_9349332_4
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000000001998
61.0
DEZH1_k127_9349332_5
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family
K05389
-
-
0.0003129
47.0
DEZH1_k127_9363254_0
transcriptional regulatory protein
-
-
-
0.000000000000000000000000000000000000000001224
165.0
DEZH1_k127_9363254_1
TIGRFAM stage V sporulation protein D
K03587,K08384
-
3.4.16.4
0.00000000000000000000000000000000000002
151.0
DEZH1_k127_9363254_10
stage V sporulation protein D
K03587,K08384
-
3.4.16.4
0.00000000001153
70.0
DEZH1_k127_9363254_11
Sigma-70 factor, region 1.2
K03086
-
-
0.0000003277
62.0
DEZH1_k127_9363254_12
Penicillin-binding protein, dimerisation domain
K03587
-
3.4.16.4
0.00000377
49.0
DEZH1_k127_9363254_13
Belongs to the small heat shock protein (HSP20) family
K13993
-
-
0.00001497
53.0
DEZH1_k127_9363254_14
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.00005449
52.0
DEZH1_k127_9363254_15
PFAM TPR repeat-containing protein
-
-
-
0.000122
50.0
DEZH1_k127_9363254_16
Cell division protein FtsI penicillin-binding protein 2
K03587
-
3.4.16.4
0.0001757
52.0
DEZH1_k127_9363254_2
4Fe-4S single cluster domain
-
-
-
0.000000000000000000000000000000000001495
145.0
DEZH1_k127_9363254_3
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.0000000000000000000000000000000002579
138.0
DEZH1_k127_9363254_4
membrane
-
-
-
0.0000000000000000000000377
106.0
DEZH1_k127_9363254_5
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
0.000000000000000001156
90.0
DEZH1_k127_9363254_6
4Fe-4S single cluster domain
-
-
-
0.0000000000000001314
82.0
DEZH1_k127_9363254_7
Sortase family
K07284
-
3.4.22.70
0.000000000000003241
85.0
DEZH1_k127_9363254_8
Domain of unknown function (DUF4010)
-
-
-
0.0000000000001197
79.0
DEZH1_k127_9363254_9
Radical SAM
-
-
-
0.000000000002534
68.0
DEZH1_k127_9439342_0
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0000000000000000000000000000000003848
135.0
DEZH1_k127_9439342_1
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000000000000000007193
133.0
DEZH1_k127_9439342_3
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000001394
96.0
DEZH1_k127_9439342_4
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
K02884
-
-
0.000000000000000000000001124
107.0
DEZH1_k127_9654626_3
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATPases associated with a variety of cellular activities
K02003
-
-
0.000000000000000000000000009823
110.0
DEZH1_k127_975675_3
Efflux ABC transporter, permease protein
K02004
-
-
0.000000000000006096
74.0
DEZH1_k127_975675_4
Efflux ABC transporter permease protein
K02004
-
-
0.0000000000824
64.0
DEZH1_k127_975675_5
COG0577 ABC-type antimicrobial peptide transport system permease component
K02004
-
-
0.000001563
53.0
DEZH1_k127_975675_6
Efflux transporter rnd family, mfp subunit
K02005
-
-
0.00001119
52.0
DEZH1_k127_975675_7
membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
K05685
-
-
0.0005763
44.0
DEZH1_k127_9844525_0
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)