Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K02945,K03527
-
1.17.7.4
0.0000000000000000000000000008982
116.0
DEZH1_k127_10103034_10
Belongs to the universal ribosomal protein uS2 family
K02967
-
-
0.0000000002549
66.0
DEZH1_k127_10103034_11
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.000000007071
57.0
DEZH1_k127_10103034_12
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.00000008907
55.0
DEZH1_k127_10103034_13
Histidine kinase
-
-
-
0.0000001669
55.0
DEZH1_k127_10103034_14
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000002
52.0
DEZH1_k127_10103034_15
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.000001289
51.0
DEZH1_k127_10103034_16
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.00006735
46.0
DEZH1_k127_10103034_18
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000000000000000000000007918
104.0
DEZH1_k127_10103034_20
Belongs to the small heat shock protein (HSP20) family
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.000703
42.0
DEZH1_k127_10103034_3
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000000000000006549
78.0
DEZH1_k127_10103034_5
Thioredoxin
K03671
-
-
0.000000000000001708
76.0
DEZH1_k127_10103034_6
Ribosomal protein S1-like RNA-binding domain
K02945
-
-
0.000000000000001908
78.0
DEZH1_k127_10103034_7
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K02357
-
-
0.00000000000089
68.0
DEZH1_k127_10103034_9
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000000001042
61.0
DEZH1_k127_10168064_0
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0000000000000000000000000000000000000002434
149.0
DEZH1_k127_10168064_1
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.00000000000000000000000001222
109.0
DEZH1_k127_10168064_10
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0000002462
52.0
DEZH1_k127_10168064_16
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K03151
-
2.8.1.4
0.000003223
51.0
DEZH1_k127_10168064_17
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K03151
-
2.8.1.4
0.00001248
47.0
DEZH1_k127_10168064_18
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
0.000000002705
58.0
DEZH1_k127_10168064_9
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03469
-
3.1.26.4
0.00000000318
58.0
DEZH1_k127_10172316_0
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K04487,K11717
-
2.8.1.7,4.4.1.16
0.000009944
49.0
DEZH1_k127_10172316_1
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
0.0008989
42.0
DEZH1_k127_10333409_0
Ferredoxin-fold anticodon binding domain
K01890
-
6.1.1.20
0.000000003827
59.0
DEZH1_k127_10333409_1
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
0.00000001915
55.0
DEZH1_k127_10333409_2
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K03553
-
-
0.000004127
48.0
DEZH1_k127_10333409_4
Psort location Cytoplasmic, score 9.98
K01890
-
6.1.1.20
0.00004851
46.0
DEZH1_k127_10334721_0
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.00000000000000000000000009353
111.0
DEZH1_k127_10334721_10
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0003703
43.0
DEZH1_k127_10334721_2
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.000000002985
57.0
DEZH1_k127_10334721_5
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.00000001528
55.0
DEZH1_k127_10334721_6
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.000000213
53.0
DEZH1_k127_10334721_7
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.000000003651
59.0
DEZH1_k127_2779555_2
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
K03624
-
-
0.000000000000000002443
87.0
DEZH1_k127_2779555_20
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
0.00000000904
56.0
DEZH1_k127_2779555_21
Participates in transcription elongation, termination and antitermination
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.0000002439
53.0
DEZH1_k127_2779555_26
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.000000389
53.0
DEZH1_k127_2779555_27
DNA helicase recQ
K03654
-
3.6.4.12
0.0000004257
52.0
DEZH1_k127_2779555_28
COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K12276
-
-
0.00000217
51.0
DEZH1_k127_2779555_29
-
-
-
-
0.00000221
49.0
DEZH1_k127_2779555_3
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.000000000000000003949
85.0
DEZH1_k127_2779555_30
Transporter associated domain
-
-
-
0.000002841
50.0
DEZH1_k127_2779555_31
Type II/IV secretion system protein
K02454
-
-
0.000004673
49.0
DEZH1_k127_2779555_32
helicase activity
-
-
-
0.000005871
52.0
DEZH1_k127_2779555_33
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
K03624
-
-
0.000007562
48.0
DEZH1_k127_2779555_34
Type IV secretion-system coupling protein DNA-binding domain
-
-
-
0.00001148
48.0
DEZH1_k127_2779555_35
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.00001506
47.0
DEZH1_k127_2779555_36
DEAD DEAH box helicase
K03654
-
3.6.4.12
0.0001228
47.0
DEZH1_k127_2779555_37
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0003641
43.0
DEZH1_k127_2779555_39
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.0003912
43.0
DEZH1_k127_2779555_4
Type II/IV secretion system protein
K02454,K02652
-
-
0.000000000000000006451
85.0
DEZH1_k127_2779555_40
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.0005693
43.0
DEZH1_k127_2779555_41
membrane
K09775
-
-
0.0006651
42.0
DEZH1_k127_2779555_42
exoribonuclease II activity
K12573,K12585
-
-
0.0006651
42.0
DEZH1_k127_2779555_43
Transporter associated domain
-
-
-
0.000703
42.0
DEZH1_k127_2779555_44
Major Facilitator Superfamily
-
-
-
0.0008326
44.0
DEZH1_k127_2779555_5
RQC
K03654
-
3.6.4.12
0.000000000000006837
76.0
DEZH1_k127_2779555_6
This protein binds to 23S rRNA in the presence of protein L20
K02888
-
-
0.0000000000001612
73.0
DEZH1_k127_2779555_7
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
0.0000009868
53.0
DEZH1_k127_2978125_14
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.000001979
49.0
DEZH1_k127_2978125_15
UvrD-like helicase C-terminal domain
K03657
-
3.6.4.12
0.000006437
49.0
DEZH1_k127_2978125_16
Aldehyde ferredoxin oxidoreductase
K03738
-
1.2.7.5
0.000009069
47.0
DEZH1_k127_2978125_17
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
K00940
-
2.7.4.6
0.00000000000000008255
80.0
DEZH1_k127_2978125_5
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
0.000000000000002728
78.0
DEZH1_k127_2978125_6
Repeats in polycystic kidney disease 1 (PKD1) and other proteins
-
-
-
0.000000000000003283
78.0
DEZH1_k127_2978125_7
Belongs to the helicase family. UvrD subfamily
K03657
-
3.6.4.12
0.00000000000001304
80.0
DEZH1_k127_2978125_8
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Specifically methylates the N7 position of a guanine in 16S rRNA
K03501
-
2.1.1.170
0.000001674
49.0
DEZH1_k127_3045802_4
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.000009793
48.0
DEZH1_k127_3045802_6
Glycosyltransferase
K20534
-
-
0.00001929
46.0
DEZH1_k127_3045802_7
glycosyl transferase group 1
-
-
-
0.00003087
48.0
DEZH1_k127_3045802_8
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Belongs to the protein N5-glutamine methyltransferase family
K02493
-
2.1.1.297
0.0000000007944
60.0
DEZH1_k127_313962_2
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K00604
-
2.1.2.9
0.000001522
51.0
DEZH1_k127_313962_3
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.000000000000001058
77.0
DEZH1_k127_3317153_20
Histidine kinase
-
-
-
0.00009613
48.0
DEZH1_k127_3317153_21
ABC transporter transmembrane region
K06147
-
-
0.0001211
45.0
DEZH1_k127_3317153_22
PFAM Response regulator receiver domain
-
-
-
0.0001393
44.0
DEZH1_k127_3317153_23
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
K05685
-
-
0.0001742
47.0
DEZH1_k127_3317153_24
PFAM ATP-grasp domain
K22224
-
6.2.1.13
0.0006524
42.0
DEZH1_k127_3317153_25
TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain
K09181
-
-
0.0008562
43.0
DEZH1_k127_3317153_3
PFAM ABC transporter related
-
-
-
0.000000000000001497
77.0
DEZH1_k127_3317153_4
Nitroreductase family
-
-
-
0.000000000000004593
76.0
DEZH1_k127_3317153_5
Belongs to the Glu Leu Phe Val dehydrogenases family
Belongs to the Glu Leu Phe Val dehydrogenases family
K00260
-
1.4.1.2
0.00000001265
57.0
DEZH1_k127_3317153_8
nitroreductase
-
-
-
0.00000001747
56.0
DEZH1_k127_3317153_9
Two component transcriptional regulator, winged helix family
K18941
-
-
0.00000003128
55.0
DEZH1_k127_3421686_0
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.00000000000000001002
84.0
DEZH1_k127_3421686_1
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.00000000000005062
71.0
DEZH1_k127_3421686_10
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K02427
-
2.1.1.166
0.0004132
43.0
DEZH1_k127_3421686_2
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K02427
-
2.1.1.166
0.00000000000007886
72.0
DEZH1_k127_3421686_3
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.000000000008715
65.0
DEZH1_k127_3421686_4
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K03716
-
4.1.99.14
0.000000008232
58.0
DEZH1_k127_3421686_5
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.00000001333
56.0
DEZH1_k127_3421686_6
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.0000007178
51.0
DEZH1_k127_3421686_7
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.0000007588
51.0
DEZH1_k127_3421686_8
radical SAM domain protein
K03716
-
4.1.99.14
0.0001643
45.0
DEZH1_k127_3421686_9
AAA domain
-
-
-
0.00025
45.0
DEZH1_k127_3441335_0
Dam-replacing family
K01155
-
3.1.21.4
0.00000000000000000000000000000000000000007279
155.0
DEZH1_k127_3441335_1
Dam-replacing family
K01155
-
3.1.21.4
0.0000000000000000000000001313
108.0
DEZH1_k127_3441335_10
CoA binding domain
-
-
-
0.00001795
48.0
DEZH1_k127_3441335_11
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K00560
-
2.1.1.45
0.0000000000000000000002319
97.0
DEZH1_k127_3441335_3
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.0000000000000001911
79.0
DEZH1_k127_3441335_4
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K00560
-
2.1.1.45
0.0000000000000008331
78.0
DEZH1_k127_3441335_5
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K00560
-
2.1.1.45
0.0000000000001196
72.0
DEZH1_k127_3441335_6
-
-
-
-
0.0000000000002048
74.0
DEZH1_k127_3441335_7
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K00560
-
2.1.1.45
0.000003476
48.0
DEZH1_k127_3441335_9
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Belongs to the NAD(P)-dependent epimerase dehydratase family
K01784
-
5.1.3.2
0.0002223
43.0
DEZH1_k127_4281264_0
Required for morphogenesis under gluconeogenic growth conditions
-
-
-
0.00000000000000003237
82.0
DEZH1_k127_4281264_1
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.000000000006623
65.0
DEZH1_k127_4281264_2
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.000000009225
57.0
DEZH1_k127_4281264_3
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Required for morphogenesis under gluconeogenic growth conditions
-
-
-
0.0000003824
52.0
DEZH1_k127_4281264_5
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.000004886
48.0
DEZH1_k127_4281264_6
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0001273
45.0
DEZH1_k127_4281264_7
Uncharacterised protein family UPF0052
-
-
-
0.0001857
44.0
DEZH1_k127_4462933_0
Necessary for normal cell division and for the maintenance of normal septation
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.000000000000000000000000000000000000000002179
158.0
DEZH1_k127_4463527_1
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.000000000000000000000000000003145
121.0
DEZH1_k127_4463527_10
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.00000007376
56.0
DEZH1_k127_4463527_11
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.000000835
50.0
DEZH1_k127_4463527_12
xyloglucan:xyloglucosyl transferase activity
-
-
-
0.00002741
48.0
DEZH1_k127_4463527_13
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.0005401
43.0
DEZH1_k127_4463527_2
polyphosphate kinase
K22468
-
2.7.4.1
0.0000000000000000000000000001781
116.0
DEZH1_k127_4463527_3
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.00000000000000009257
79.0
DEZH1_k127_4463527_4
polyphosphate kinase
K22468
-
2.7.4.1
0.000000000001045
68.0
DEZH1_k127_4463527_5
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.00000000001345
66.0
DEZH1_k127_4463527_6
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.0000000008812
59.0
DEZH1_k127_4463527_7
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.000000004148
57.0
DEZH1_k127_4463527_8
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
0.00000002635
55.0
DEZH1_k127_4463527_9
COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)
K05844,K14940
-
6.3.2.32
0.0000000715
55.0
DEZH1_k127_4588663_0
Molecular chaperone. Has ATPase activity
K04079
-
-
0.00000000000000483
76.0
DEZH1_k127_4588663_1
Isopentenyl-diphosphate delta-isomerase
K01823
-
5.3.3.2
0.0000000000006818
69.0
DEZH1_k127_4588663_10
PFAM Acyltransferase
-
-
-
0.00002025
51.0
DEZH1_k127_4588663_11
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ATPase associated with various cellular activities
K03924
-
-
0.00000002613
56.0
DEZH1_k127_5329210_29
Von Willebrand factor type A domain
K07114
-
-
0.00000002971
55.0
DEZH1_k127_5329210_3
Belongs to the pseudouridine synthase RsuA family
K06178
-
5.4.99.22
0.00000000000000000000000000005308
116.0
DEZH1_k127_5329210_30
ATP-dependent DNA helicase activity
K03658,K16898
-
3.6.4.12
0.00000004283
54.0
DEZH1_k127_5329210_31
Transcriptional regulatory protein, C terminal
K02483
-
-
0.00000004774
55.0
DEZH1_k127_5329210_32
Bacterial sugar transferase
-
-
-
0.00000009584
54.0
DEZH1_k127_5329210_33
ATPase family associated with various cellular activities (AAA)
K03924
-
-
0.0000001375
53.0
DEZH1_k127_5329210_34
Protein of unknown function DUF58
-
-
-
0.0000005201
52.0
DEZH1_k127_5329210_35
Domain of unknown function (DUF4105)
-
-
-
0.0000006709
55.0
DEZH1_k127_5329210_36
COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K05770
-
-
0.000001333
49.0
DEZH1_k127_5329210_37
it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K03629
-
-
0.000001963
51.0
DEZH1_k127_5329210_38
MatE
-
-
-
0.000004785
48.0
DEZH1_k127_5329210_39
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.000006558
49.0
DEZH1_k127_5329210_4
Belongs to the DEAD box helicase family
K05592
-
3.6.4.13
0.00000000000000000000000002229
108.0
DEZH1_k127_5329210_40
Glycosyl transferases group 1
-
-
-
0.00001436
49.0
DEZH1_k127_5329210_41
TspO/MBR family
K05770
-
-
0.00001929
46.0
DEZH1_k127_5329210_42
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.00002085
49.0
DEZH1_k127_5329210_43
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.00002848
47.0
DEZH1_k127_5329210_44
Uncharacterized protein domain (DUF2202)
-
-
-
0.00004754
45.0
DEZH1_k127_5329210_45
Belongs to the pirin family
K06911
-
-
0.00005418
46.0
DEZH1_k127_5329210_46
Polysaccharide biosynthesis C-terminal domain
-
-
-
0.00006547
45.0
DEZH1_k127_5329210_47
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K18303
-
-
0.00009277
45.0
DEZH1_k127_5329210_48
Signal transduction histidine kinase
-
-
-
0.0001407
48.0
DEZH1_k127_5329210_49
Histidine kinase
-
-
-
0.0001621
46.0
DEZH1_k127_5329210_5
Belongs to the pseudouridine synthase RsuA family
K06178
-
5.4.99.22
0.000000000000000000000001798
103.0
DEZH1_k127_5329210_50
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.0001742
47.0
DEZH1_k127_5329210_51
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.0001959
44.0
DEZH1_k127_5329210_52
Uncharacterized protein domain (DUF2202)
-
-
-
0.0002061
44.0
DEZH1_k127_5329210_53
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Threonylcarbamoyl adenosine biosynthesis protein TsaE
K06925
-
-
0.0006291
42.0
DEZH1_k127_5329210_58
Histidine kinase
-
-
-
0.0006968
44.0
DEZH1_k127_5329210_6
Domain of unknown function (DUF4105)
-
-
-
0.000000000000000000003466
95.0
DEZH1_k127_5329210_7
transcriptional regulator
K10947
-
-
0.000000000000000000059
91.0
DEZH1_k127_5329210_8
PFAM DNA photolyase FAD-binding
K01669
-
4.1.99.3
0.0000000000000000007902
87.0
DEZH1_k127_5329210_9
Transcriptional regulatory protein, C terminal
K02483
-
-
0.00000000000000007448
80.0
DEZH1_k127_5332978_0
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP
K19788
-
-
0.00000000000000000002364
91.0
DEZH1_k127_5332978_1
RNA-binding PUA-like domain of methyltransferase RsmF
-
-
-
0.000002832
49.0
DEZH1_k127_5332978_2
NOL1 NOP2 sun family protein
-
-
-
0.00001774
47.0
DEZH1_k127_5332978_3
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
K06942
-
-
0.0008002
42.0
DEZH1_k127_5439987_0
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K02871
-
-
0.0000000000000000000000000000000002057
134.0
DEZH1_k127_5439987_1
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0000000000000000000000001802
108.0
DEZH1_k127_5439987_10
Belongs to the universal ribosomal protein uS9 family
K02996
-
-
0.00000000000004256
73.0
DEZH1_k127_5439987_11
Belongs to the bacterial ribosomal protein bL36 family
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00000000001025
65.0
DEZH1_k127_5439987_14
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K02948
-
-
0.00000000002781
64.0
DEZH1_k127_5439987_15
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00000000136
59.0
DEZH1_k127_5439987_17
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K02950
-
-
0.00000000000000000001508
93.0
DEZH1_k127_5439987_20
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0000001161
53.0
DEZH1_k127_5439987_23
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Belongs to the universal ribosomal protein uS9 family
K02996
-
-
0.0000009651
52.0
DEZH1_k127_5439987_25
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K02986
-
-
0.000006674
50.0
DEZH1_k127_5439987_26
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00001929
46.0
DEZH1_k127_5439987_27
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00006179
45.0
DEZH1_k127_5439987_28
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
K02992
-
-
0.000000000000000001453
87.0
DEZH1_k127_5439987_30
dTDP-glucose pyrophosphorylase
K00973
-
2.7.7.24
0.0003855
43.0
DEZH1_k127_5439987_4
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00000000000000001784
81.0
DEZH1_k127_5439987_6
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.000000000000002461
76.0
DEZH1_k127_5439987_8
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.00000000000003154
72.0
DEZH1_k127_5642198_0
TIGRFAM YD repeat protein
-
-
-
0.000001464
51.0
DEZH1_k127_5642198_1
YD repeat (two copies)
-
-
-
0.000008327
50.0
DEZH1_k127_5690496_0
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K02874
-
-
0.0000000000000000000000000000000000001098
143.0
DEZH1_k127_5690496_1
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K02994
-
-
0.0000000000000000000000000001641
119.0
DEZH1_k127_5690496_10
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.00000000241
59.0
DEZH1_k127_5690496_13
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K02931
-
-
0.0000004722
51.0
DEZH1_k127_5690496_21
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K02890
-
-
0.0000005859
51.0
DEZH1_k127_5690496_22
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K02886
-
-
0.000000000000006312
75.0
DEZH1_k127_5690496_8
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
0.000000000003019
67.0
DEZH1_k127_5690496_9
ribosomal protein L3
K02906
-
-
0.00000000001376
66.0
DEZH1_k127_5723611_0
Methyladenine glycosylase
-
-
-
0.00000000000000000000000000000009927
125.0
DEZH1_k127_5723611_1
Fic/DOC family N-terminal
-
-
-
0.0000000000001063
71.0
DEZH1_k127_5723611_10
Hint domain
-
-
-
0.0001496
44.0
DEZH1_k127_5723611_11
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0003166
44.0
DEZH1_k127_5723611_2
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0000000000006116
68.0
DEZH1_k127_5723611_3
Methyladenine glycosylase
K01246
-
3.2.2.20
0.000000000006031
66.0
DEZH1_k127_5723611_4
Fic/DOC family N-terminal
-
-
-
0.000000001097
59.0
DEZH1_k127_5723611_5
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.00003852
47.0
DEZH1_k127_5790146_0
-
-
-
-
0.0000000000000000004713
88.0
DEZH1_k127_5790146_1
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
-
-
0.0000000000000326
74.0
DEZH1_k127_5790146_2
Hydrolase, TatD family
K03424
-
-
0.00000000000134
71.0
DEZH1_k127_5790146_3
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K06187
-
-
0.0005123
43.0
DEZH1_k127_5924276_15
assembly protein SufB
K09014
-
-
0.0009522
42.0
DEZH1_k127_5924276_2
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
K01916
-
6.3.1.5
0.000000000000003576
77.0
DEZH1_k127_6037295_12
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.000000000000008832
74.0
DEZH1_k127_6037295_13
HD superfamily hydrolase
K06950
-
-
0.0000000000000128
74.0
DEZH1_k127_6037295_14
Belongs to the bacterial solute-binding protein 9 family
K09815
-
-
0.000000000000135
73.0
DEZH1_k127_6037295_15
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
0.0000000000002624
70.0
DEZH1_k127_6037295_16
COG2183 Transcriptional accessory protein
K06959
-
-
0.0000000000004013
72.0
DEZH1_k127_6037295_17
Domain of unknown function (DUF1846)
-
-
-
0.000000000001344
69.0
DEZH1_k127_6037295_18
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.000000000001409
69.0
DEZH1_k127_6037295_19
DUF218 domain
K03748
-
-
0.000000000002579
67.0
DEZH1_k127_6037295_2
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
K02935
-
-
0.0000000000000000000000000000000000004422
143.0
DEZH1_k127_6037295_20
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
0.000000000005418
66.0
DEZH1_k127_6037295_21
Na Pi-cotransporter
K03324
-
-
0.000000000008388
69.0
DEZH1_k127_6037295_22
Multicopper oxidase
-
-
-
0.00000000005582
63.0
DEZH1_k127_6037295_23
Multicopper oxidase
-
-
-
0.0000000001157
63.0
DEZH1_k127_6037295_24
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530
-
-
0.0000000003857
62.0
DEZH1_k127_6037295_25
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
0.000000000661
61.0
DEZH1_k127_6037295_26
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.000000001681
59.0
DEZH1_k127_6037295_27
Na Pi-cotransporter
K03324
-
-
0.000000002561
58.0
DEZH1_k127_6037295_28
Zinc-uptake complex component A periplasmic
K09815,K09818
-
-
0.00000000304
61.0
DEZH1_k127_6037295_29
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.0000001962
52.0
DEZH1_k127_6037295_38
pyruvate flavodoxin ferredoxin oxidoreductase domain protein
K00174
-
1.2.7.11,1.2.7.3
0.0000002018
53.0
DEZH1_k127_6037295_39
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K02356
-
-
0.000000237
53.0
DEZH1_k127_6037295_4
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
0.00000000000000000000000001139
113.0
DEZH1_k127_6037295_40
Transcriptional accessory protein
K06959
-
-
0.000000237
53.0
DEZH1_k127_6037295_41
Domain of unknown function (DUF4153)
-
-
-
0.0000004618
53.0
DEZH1_k127_6037295_42
HD superfamily hydrolase
K06950
-
-
0.0000006868
51.0
DEZH1_k127_6037295_43
Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
K00174
-
1.2.7.11,1.2.7.3
0.000001104
50.0
DEZH1_k127_6037295_44
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
0.000001149
50.0
DEZH1_k127_6037295_45
ATPase family associated with various cellular activities (AAA)
-
-
-
0.000001691
51.0
DEZH1_k127_6037295_46
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.000002064
51.0
DEZH1_k127_6037295_47
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Extradiol ring-cleavage dioxygenase class III protein subunit B
K15777
-
-
0.000002998
49.0
DEZH1_k127_6037295_49
Tex-like protein
K06959
-
-
0.000003214
49.0
DEZH1_k127_6037295_5
'Cold-shock' DNA-binding domain
K03704
-
-
0.000000000000000000001808
94.0
DEZH1_k127_6037295_50
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.000003876
52.0
DEZH1_k127_6037295_51
Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K00763
-
6.3.4.21
0.000004199
50.0
DEZH1_k127_6037295_52
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.000004537
50.0
DEZH1_k127_6037295_53
Multicopper oxidase
-
-
-
0.000005769
48.0
DEZH1_k127_6037295_54
HD superfamily hydrolase
K06950
-
-
0.000007976
48.0
DEZH1_k127_6037295_55
Single-stranded DNA-binding protein
K03111
-
-
0.00001261
49.0
DEZH1_k127_6037295_56
NUDIX domain
K03574
-
3.6.1.55
0.00002042
46.0
DEZH1_k127_6037295_57
Tex-like protein N-terminal domain protein
K06959
-
-
0.00003046
49.0
DEZH1_k127_6037295_58
impB/mucB/samB family
K02346,K03502
-
2.7.7.7
0.00003086
51.0
DEZH1_k127_6037295_59
oxidoreductase beta subunit
K00175
-
1.2.7.11,1.2.7.3
0.00003259
46.0
DEZH1_k127_6037295_6
Domain of unknown function (DUF1846)
-
-
-
0.00000000000000000002765
93.0
DEZH1_k127_6037295_60
ABC transporter
K01990
-
-
0.00003364
46.0
DEZH1_k127_6037295_61
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.00004682
47.0
DEZH1_k127_6037295_62
nucleotidyltransferase DNA polymerase involved in DNA repair
K03502
-
-
0.00008874
46.0
DEZH1_k127_6037295_63
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K02864
-
-
0.00009243
46.0
DEZH1_k127_6037295_64
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
K03530,K04764
-
-
0.0001172
44.0
DEZH1_k127_6037295_65
Belongs to the peptidase S26 family
K03100
-
3.4.21.89
0.0001591
47.0
DEZH1_k127_6037295_66
Multicopper oxidase
-
-
-
0.0001754
45.0
DEZH1_k127_6037295_67
Na Pi-cotransporter
K03324
-
-
0.0001846
44.0
DEZH1_k127_6037295_68
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K00969
-
2.7.7.18
0.0001945
46.0
DEZH1_k127_6037295_69
Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
K00174
-
1.2.7.11,1.2.7.3
0.0002309
48.0
DEZH1_k127_6037295_7
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K02864
-
-
0.0002488
47.0
DEZH1_k127_6037295_72
Belongs to the peptidase S26 family
K03100
-
3.4.21.89
0.0003438
43.0
DEZH1_k127_6037295_73
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K02346
-
2.7.7.7
0.0005401
43.0
DEZH1_k127_6037295_79
PFAM peptidase U32
K08303
-
-
0.0005555
44.0
DEZH1_k127_6037295_8
Ribosomal protein L31
K02909
-
-
0.0000000000000001533
84.0
DEZH1_k127_6037295_80
TIGRFAM Fibrobacter succinogenes major paralogous domain
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
K01916
-
6.3.1.5
0.0008195
42.0
DEZH1_k127_6037295_85
PFAM Na Picotransporter
K03324
-
-
0.0008381
44.0
DEZH1_k127_6037295_86
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
-
-
-
0.0009645
43.0
DEZH1_k127_6037295_9
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0000000000000000000000000000000009921
134.0
DEZH1_k127_6155101_10
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.000000000003019
67.0
DEZH1_k127_6155101_11
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
0.000000000006014
66.0
DEZH1_k127_6155101_12
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.00000000001258
67.0
DEZH1_k127_6155101_13
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.00000000002794
63.0
DEZH1_k127_6155101_14
Ribonucleotide reductase, small chain
K00526
-
1.17.4.1
0.00000000002873
65.0
DEZH1_k127_6155101_15
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.0000000001354
61.0
DEZH1_k127_6155101_16
RmuC family
K09760
-
-
0.0000000004122
62.0
DEZH1_k127_6155101_17
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.0000000007458
59.0
DEZH1_k127_6155101_18
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.000000001026
59.0
DEZH1_k127_6155101_19
anaerobic ribonucleoside-triphosphate reductase activating protein
K04069
-
1.97.1.4
0.00000001265
57.0
DEZH1_k127_6155101_2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
0.00000000000000000000000000003199
117.0
DEZH1_k127_6155101_20
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K07738
-
-
0.0000003026
51.0
DEZH1_k127_6155101_22
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.000001029
52.0
DEZH1_k127_6155101_23
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09765
-
1.17.99.6
0.000002104
50.0
DEZH1_k127_6155101_24
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.00002173
48.0
DEZH1_k127_6155101_27
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K07738
-
-
0.00008326
45.0
DEZH1_k127_6155101_28
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.000176
44.0
DEZH1_k127_6155101_29
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0003284
46.0
DEZH1_k127_6155101_3
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.000000000000000000000000001034
114.0
DEZH1_k127_6155101_4
ATP cone domain
K21636
-
1.1.98.6
0.00000000000000000000002024
100.0
DEZH1_k127_6155101_5
Ribonucleotide reductase, all-alpha domain
K00525
-
1.17.4.1
0.000000000000000000001078
95.0
DEZH1_k127_6155101_6
Ribonucleoside-triphosphate reductase
K21636
-
1.1.98.6
0.000000000000000003419
85.0
DEZH1_k127_6155101_7
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.00000000000000003383
81.0
DEZH1_k127_6222125_14
Ribosomal protein S10p/S20e
K02946
-
-
0.00000000000000003708
81.0
DEZH1_k127_6222125_15
GTP-binding protein TypA
K06207
-
-
0.00000000000000004639
81.0
DEZH1_k127_6222125_16
Psort location Cytoplasmic, score
K02337,K14162
-
2.7.7.7
0.00000000000000006382
83.0
DEZH1_k127_6222125_17
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K02836
-
-
0.0000000000000004259
78.0
DEZH1_k127_6222125_19
-
-
-
-
0.000000000000006082
74.0
DEZH1_k127_6222125_2
-
-
-
-
0.000000000000000000000000000000002002
130.0
DEZH1_k127_6222125_20
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
0.00000000000001747
72.0
DEZH1_k127_6222125_21
DNA-directed DNA polymerase
K02337
-
2.7.7.7
0.00000000000002142
74.0
DEZH1_k127_6222125_22
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.00000000000005362
72.0
DEZH1_k127_6222125_23
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.00000000000007322
73.0
DEZH1_k127_6222125_24
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K03768
-
5.2.1.8
0.0000000000002871
70.0
DEZH1_k127_6222125_25
-
-
-
-
0.0000000000003462
72.0
DEZH1_k127_6222125_26
TIGRFAM DNA polymerase III, alpha subunit
K02337
-
2.7.7.7
0.0000000000004905
70.0
DEZH1_k127_6222125_27
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.000000000002308
66.0
DEZH1_k127_6222125_29
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000004374
66.0
DEZH1_k127_6222125_3
COG NOG15344 non supervised orthologous group
-
-
-
0.000000000000000000000000000000005023
132.0
DEZH1_k127_6222125_30
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria
K02337,K14162
-
2.7.7.7
0.0000000001329
64.0
DEZH1_k127_6222125_38
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K07568
-
2.4.99.17
0.0000000002462
61.0
DEZH1_k127_6222125_39
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K03763
-
2.7.7.7
0.0000000002981
64.0
DEZH1_k127_6222125_4
GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
0.000000000000000000000000004661
109.0
DEZH1_k127_6222125_40
PFAM Exonuclease, RNase T and DNA polymerase III
K02342,K03722
-
2.7.7.7,3.6.4.12
0.0000000004224
61.0
DEZH1_k127_6222125_41
helicase activity
K03466,K12217
-
-
0.0000000004693
61.0
DEZH1_k127_6222125_42
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K03979
-
-
0.0000000005498
63.0
DEZH1_k127_6222125_43
PFAM DSBA oxidoreductase
-
-
-
0.0000000008645
67.0
DEZH1_k127_6222125_44
helicase activity
-
-
-
0.00000000106
62.0
DEZH1_k127_6222125_45
amine dehydrogenase activity
K19668,K20276
-
3.2.1.91
0.000000001775
61.0
DEZH1_k127_6222125_46
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.000000001871
59.0
DEZH1_k127_6222125_47
protein histidine kinase activity
-
-
-
0.000000002917
60.0
DEZH1_k127_6222125_48
Radical SAM methylthiotransferase, MiaB RimO family
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0000004035
52.0
DEZH1_k127_6222125_67
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02652
-
-
0.0000004932
51.0
DEZH1_k127_6222125_68
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0000008834
50.0
DEZH1_k127_6222125_71
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.000001286
50.0
DEZH1_k127_6222125_72
Belongs to the pseudouridine synthase RsuA family
K06178,K06182
-
5.4.99.21,5.4.99.22
0.000001333
49.0
DEZH1_k127_6222125_73
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
0.000001771
49.0
DEZH1_k127_6222125_74
Peptidyl-prolyl cis-trans isomerase
K01802,K03767,K03768
-
5.2.1.8
0.000001835
49.0
DEZH1_k127_6222125_75
Phosphoribosyl transferase domain
-
-
-
0.000003462
50.0
DEZH1_k127_6222125_76
Cell wall formation
K00075
-
1.3.1.98
0.00000462
48.0
DEZH1_k127_6222125_77
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
K03111
-
-
0.000005121
49.0
DEZH1_k127_6222125_78
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
0.000006107
49.0
DEZH1_k127_6222125_79
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.000006978
48.0
DEZH1_k127_6222125_8
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.00001791
49.0
DEZH1_k127_6222125_84
general secretion pathway protein
K02455
-
-
0.00001976
48.0
DEZH1_k127_6222125_85
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0002298
44.0
DEZH1_k127_6222125_92
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0003504
44.0
DEZH1_k127_6222125_93
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.000408
43.0
DEZH1_k127_6222125_94
Adenylyl cyclase class-3 4 guanylyl cyclase
K01768
-
4.6.1.1
0.0004736
42.0
DEZH1_k127_6222125_95
DNA polymerase
K02337,K14162
-
2.7.7.7
0.0005693
43.0
DEZH1_k127_6222125_98
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0007843
43.0
DEZH1_k127_6222125_99
DNA polymerase III
K02337
-
2.7.7.7
0.0008741
42.0
DEZH1_k127_661835_0
DHH family
K07462
-
-
0.000000006668
57.0
DEZH1_k127_661835_1
single-stranded-DNA-specific exonuclease RecJ
K07462
-
-
0.000000007478
58.0
DEZH1_k127_661835_2
Single-stranded-DNA-specific exonuclease RecJ
K07462
-
-
0.000006674
50.0
DEZH1_k127_6740799_0
TIGRFAM YD repeat protein
-
-
-
0.00000000000001669
73.0
DEZH1_k127_6740799_1
TIGRFAM YD repeat protein
-
-
-
0.000000000001977
67.0
DEZH1_k127_6740799_2
RHS Repeat
-
-
-
0.0000102
49.0
DEZH1_k127_6790009_0
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.00000000005533
64.0
DEZH1_k127_6790009_1
Sigma-70 factor, region 1.2
K03086
-
-
0.00000005334
55.0
DEZH1_k127_6790009_2
radical SAM
-
-
-
0.0003276
44.0
DEZH1_k127_7148257_0
Participates in initiation and elongation during chromosome replication
K02314
-
3.6.4.12
0.000000000000000000000004658
102.0
DEZH1_k127_7148257_1
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0000000000000000001971
88.0
DEZH1_k127_7148257_10
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.000002335
49.0
DEZH1_k127_7148257_12
PFAM Tetratricopeptide repeat
-
-
-
0.000004196
52.0
DEZH1_k127_7148257_13
Participates in initiation and elongation during chromosome replication
K02314
-
3.6.4.12
0.000004807
51.0
DEZH1_k127_7148257_14
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
-
3.6.4.12
0.000009839
48.0
DEZH1_k127_7148257_15
Rossmann fold nucleotide-binding protein involved in DNA uptake
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.00008874
46.0
DEZH1_k127_7148257_19
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0002798
43.0
DEZH1_k127_7148257_2
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.000000000000000007554
85.0
DEZH1_k127_7148257_20
Synthesizes alpha-1,4-glucan chains using ADP-glucose
K00703
-
2.4.1.21
0.0004874
46.0
DEZH1_k127_7148257_21
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.000000000000000952
76.0
DEZH1_k127_7148257_4
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.00000000002138
66.0
DEZH1_k127_7148257_5
COG0551 Zn-finger domain associated with topoisomerase type I
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.000000001428
59.0
DEZH1_k127_7148257_7
Participates in initiation and elongation during chromosome replication
K02314
-
3.6.4.12
0.00000000177
59.0
DEZH1_k127_7148257_8
Participates in initiation and elongation during chromosome replication
K02314
-
3.6.4.12
0.00000002225
55.0
DEZH1_k127_7148257_9
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.0000005513
51.0
DEZH1_k127_726576_0
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.000000000000000001054
86.0
DEZH1_k127_726576_1
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03086
-
-
0.0000000000000003119
78.0
DEZH1_k127_726576_2
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.000000004276
61.0
DEZH1_k127_726576_3
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.000000835
50.0
DEZH1_k127_726576_4
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.000007943
48.0
DEZH1_k127_7289822_0
TIGRFAM histone acetyltransferase, ELP3 family
K07739
-
2.3.1.48
0.0000000000008812
69.0
DEZH1_k127_7289822_1
CorA-like Mg2+ transporter protein
K03284
-
-
0.0000006857
53.0
DEZH1_k127_7289822_2
SMART Elongator protein 3 MiaB NifB
K07739
-
2.3.1.48
0.00004389
46.0
DEZH1_k127_7289822_3
TIGRFAM histone acetyltransferase, ELP3 family
K07739
-
2.3.1.48
0.0001086
45.0
DEZH1_k127_7289822_4
phosphorylase kinase regulator activity
-
-
-
0.0002416
44.0
DEZH1_k127_7299943_0
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
K01358
-
3.4.21.92
0.0000000001619
61.0
DEZH1_k127_7299943_13
UvrD/REP helicase N-terminal domain
K03657
-
3.6.4.12
0.0000000004657
60.0
DEZH1_k127_7299943_14
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
0.0000000005422
59.0
DEZH1_k127_7299943_15
DNA helicase
K03657
-
3.6.4.12
0.0000000005569
61.0
DEZH1_k127_7299943_16
maintenance of DNA repeat elements
K15342
-
-
0.0000000007165
60.0
DEZH1_k127_7299943_17
ATP-dependent DNA helicase
K03657
-
3.6.4.12
0.000000002574
58.0
DEZH1_k127_7299943_18
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03074
-
-
0.000000006023
57.0
DEZH1_k127_7299943_19
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
0.000000008745
57.0
DEZH1_k127_7299943_2
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
0.00000000000000000004097
91.0
DEZH1_k127_7299943_20
N-6 DNA methylase
-
-
-
0.0000000181
55.0
DEZH1_k127_7299943_21
ATP-dependent DNA helicase
K03657
-
3.6.4.12
0.00000003427
54.0
DEZH1_k127_7299943_22
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K15342
-
-
0.00000003625
54.0
DEZH1_k127_7299943_23
Clp protease
K01358
-
3.4.21.92
0.00000004457
54.0
DEZH1_k127_7299943_24
Asparaginase, N-terminal
K01424
-
3.5.1.1
0.00000007658
55.0
DEZH1_k127_7299943_25
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.0000001009
53.0
DEZH1_k127_7299943_26
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
COG1132 ABC-type multidrug transport system, ATPase and permease components
K06147,K11085
-
-
0.0000002499
53.0
DEZH1_k127_7299943_29
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.0000004232
51.0
DEZH1_k127_7299943_3
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.000001166
50.0
DEZH1_k127_7299943_34
prohibitin homologues
-
-
-
0.000001483
52.0
DEZH1_k127_7299943_35
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
0.0000000000000000005435
88.0
DEZH1_k127_7299943_40
Alpha beta hydrolase
K00433,K01055
-
1.11.1.10,3.1.1.24
0.00009243
46.0
DEZH1_k127_7299943_41
DNA helicase
K03657
-
3.6.4.12
0.0002031
44.0
DEZH1_k127_7299943_42
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885,K09698
-
6.1.1.17,6.1.1.24
0.0002294
44.0
DEZH1_k127_7299943_43
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
0.0000000000000001194
80.0
DEZH1_k127_7381263_2
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
0.000000000000000000627
87.0
DEZH1_k127_7572124_1
Type II/IV secretion system protein
K02669
-
-
0.00000000000002551
72.0
DEZH1_k127_7572124_10
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
0.000000000002866
66.0
DEZH1_k127_7572124_3
Type II/IV secretion system protein
K02669
-
-
0.00000000009536
62.0
DEZH1_k127_7572124_4
Heparinase II/III-like protein
-
-
-
0.000000005406
57.0
DEZH1_k127_7572124_6
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
0.00000008111
53.0
DEZH1_k127_7572124_7
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.00000000000003941
74.0
DEZH1_k127_7730708_10
Catalyzes the reversible phosphorylation of UMP to UDP
K09903
-
2.7.4.22
0.0008668
42.0
DEZH1_k127_7730708_2
Glycosyl transferases group 1
-
-
-
0.00000000000667
66.0
DEZH1_k127_7730708_3
Belongs to the RNA methyltransferase TrmD family
K00554
-
2.1.1.228
0.000000003096
59.0
DEZH1_k127_7730708_4
hydrolase of the metallo-beta-lactamase superfamily
K12574
-
-
0.00000003873
55.0
DEZH1_k127_7730708_5
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
-
-
-
0.0000001166
54.0
DEZH1_k127_7730708_6
Isoprenylcysteine carboxyl methyltransferase (ICMT) family
-
-
-
0.0000009881
50.0
DEZH1_k127_7730708_7
protein-S-isoprenylcysteine methyltransferase
-
-
-
0.0000439
46.0
DEZH1_k127_7730708_8
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0007442
43.0
DEZH1_k127_7766106_0
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.000000000000006772
74.0
DEZH1_k127_7766106_11
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0000000000001632
70.0
DEZH1_k127_7766106_13
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
0.00000000002146
64.0
DEZH1_k127_7766106_14
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
0.00000000006933
63.0
DEZH1_k127_7766106_16
HD domain
K07023
-
-
0.000000002036
61.0
DEZH1_k127_7766106_17
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.0000003243
53.0
DEZH1_k127_7766106_18
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.00001821
46.0
DEZH1_k127_7766106_22
Psort location CytoplasmicMembrane, score
K02238
-
-
0.0008007
44.0
DEZH1_k127_7766106_3
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.000000000000000000001935
94.0
DEZH1_k127_7766106_4
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0000000000000000002098
89.0
DEZH1_k127_7766106_5
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K03572
-
-
0.0000000000000000818
81.0
DEZH1_k127_7766106_6
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.00000000000000009257
79.0
DEZH1_k127_7766106_7
Endoribonuclease that initiates mRNA decay
K18682
-
-
0.0000000000000005485
78.0
DEZH1_k127_7766106_8
Endoribonuclease that initiates mRNA decay
K18682
-
-
0.0000000000000008331
78.0
DEZH1_k127_7766106_9
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K03648
-
3.2.2.27
0.00000027
51.0
DEZH1_k127_7903941_5
Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K00995
-
2.7.8.5
0.000001949
58.0
DEZH1_k127_7903941_6
Dipeptidyl carboxypeptidase II
K01284
-
3.4.15.5
0.000008758
48.0
DEZH1_k127_7903941_7
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.0000000000001534
70.0
DEZH1_k127_7935152_13
Radical SAM
-
-
-
0.0000000000005159
70.0
DEZH1_k127_7935152_14
Sigma-70 region 2
K03088
-
-
0.00000000001504
66.0
DEZH1_k127_7935152_15
4Fe-4S single cluster domain
-
-
-
0.0000000000468
64.0
DEZH1_k127_7935152_16
Heat shock 70 kDa protein
K04043
-
-
0.000000001212
59.0
DEZH1_k127_7935152_17
HD domain
K07023
-
-
0.000000003998
60.0
DEZH1_k127_7935152_18
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
0.00000001187
57.0
DEZH1_k127_7935152_19
PFAM Radical SAM domain protein
K06871,K06941
-
2.1.1.192
0.00000009362
55.0
DEZH1_k127_7935152_2
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.00000000000000000000000000000000000000005956
152.0
DEZH1_k127_7935152_20
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K02115
-
-
0.000000146
55.0
DEZH1_k127_7935152_21
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K00783
-
2.1.1.177
0.0000005258
52.0
DEZH1_k127_7935152_22
HD domain
K07023
-
-
0.0000006418
51.0
DEZH1_k127_7935152_23
-
-
-
-
0.0000007365
52.0
DEZH1_k127_7935152_24
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.000001828
51.0
DEZH1_k127_7935152_25
Belongs to the pseudouridine synthase RluA family
K06179
-
5.4.99.24
0.000002599
50.0
DEZH1_k127_7935152_26
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.0000114
47.0
DEZH1_k127_7935152_27
cog cog0116
K07444
-
-
0.00001323
47.0
DEZH1_k127_7935152_28
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.00005305
49.0
DEZH1_k127_7935152_3
Heat shock 70 kDa protein
K04043
-
-
0.000000000000000000000000000000000007394
138.0
DEZH1_k127_7935152_30
DNA polymerase III subunit epsilon
K02342
-
2.7.7.7
0.0001485
45.0
DEZH1_k127_7935152_31
ATP synthase F(0) sector subunit b
K02109
-
-
0.0001873
50.0
DEZH1_k127_7935152_32
-
-
-
-
0.0003695
46.0
DEZH1_k127_7935152_33
Responsible for synthesis of pseudouridine from uracil
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.000703
42.0
DEZH1_k127_7935152_38
Beta propeller domain
-
-
-
0.0008077
46.0
DEZH1_k127_7935152_4
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.00000000000000000000000003263
108.0
DEZH1_k127_7935152_6
Heat shock 70 kDa protein
K04043
-
-
0.00000000000000000000000006439
111.0
DEZH1_k127_7935152_7
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
0.000000000000000000005991
92.0
DEZH1_k127_7935152_8
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ATPases associated with a variety of cellular activities
K02049
-
-
0.0002839
44.0
DEZH1_k127_8203015_21
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0005303
44.0
DEZH1_k127_8203015_3
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
0.00000000000000000000001672
101.0
DEZH1_k127_8203015_4
Catalyzes the attachment of glycine to tRNA(Gly)
K01880
-
6.1.1.14
0.0000000000000000000001453
97.0
DEZH1_k127_8203015_5
Belongs to the class-II aminoacyl-tRNA synthetase family
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.00000000000000302
76.0
DEZH1_k127_8203015_8
polyphosphate kinase
K22468
-
2.7.4.1
0.000000000000003592
78.0
DEZH1_k127_8203015_9
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567
-
6.1.1.6
0.0000000000000128
74.0
DEZH1_k127_8212906_0
COG1055 Na H antiporter NhaD and related arsenite permeases
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Regulator of chromosome condensation (RCC1) repeat
-
-
-
0.0000008507
51.0
DEZH1_k127_8212906_7
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.00000000000000000000000000000000003327
138.0
DEZH1_k127_8263143_1
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.0000000000000000000000000000000002042
134.0
DEZH1_k127_8263143_10
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.000004217
51.0
DEZH1_k127_8263143_17
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.000004927
49.0
DEZH1_k127_8263143_18
RNA methylase, SpoU family K00599
-
-
-
0.00001749
48.0
DEZH1_k127_8263143_19
Belongs to the ClpA ClpB family
K03694,K03695
-
-
0.00002868
47.0
DEZH1_k127_8263143_2
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.000000000000000000000000002741
110.0
DEZH1_k127_8263143_20
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
K09761
-
2.1.1.193
0.00004342
49.0
DEZH1_k127_8263143_21
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.0004604
43.0
DEZH1_k127_8263143_22
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.0005016
42.0
DEZH1_k127_8263143_23
Redoxin
K03564
-
1.11.1.15
0.0005311
42.0
DEZH1_k127_8263143_3
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.000000000000000000000000002988
115.0
DEZH1_k127_8263143_4
protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates
K01741
-
4.2.99.18
0.0000000000000000000002212
100.0
DEZH1_k127_8263143_5
Belongs to the low molecular weight phosphotyrosine protein phosphatase family
-
-
-
0.00000000000000003218
84.0
DEZH1_k127_8263143_6
COG0433 Predicted ATPase
-
-
-
0.000000000000000815
78.0
DEZH1_k127_8263143_7
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.000000000000682
68.0
DEZH1_k127_8263143_8
Chaperone protein
K03695
-
-
0.000000000001289
67.0
DEZH1_k127_8263143_9
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695
-
-
0.00000000007303
63.0
DEZH1_k127_8333005_0
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000000000000000000000000000000002658
163.0
DEZH1_k127_8333005_1
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000002909
70.0
DEZH1_k127_8333005_14
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000002859
51.0
DEZH1_k127_8333005_23
Beta-Casp domain
K07577
-
-
0.0000003013
54.0
DEZH1_k127_8333005_24
Belongs to the ClpA ClpB family
K03695
-
-
0.0000006789
51.0
DEZH1_k127_8333005_25
penicillin-binding protein 1A
K05366
-
2.4.1.129,3.4.16.4
0.0000009344
50.0
DEZH1_k127_8333005_26
Phage integrase, N-terminal SAM-like domain
-
-
-
0.000003965
49.0
DEZH1_k127_8333005_27
Belongs to the MurCDEF family
K01924
-
6.3.2.8
0.00001934
48.0
DEZH1_k127_8333005_28
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
K01056
-
3.1.1.29
0.00003331
46.0
DEZH1_k127_8333005_29
exonuclease of the beta-lactamase fold involved in RNA processing
K07576
-
-
0.00009764
46.0
DEZH1_k127_8333005_3
Belongs to the ClpA ClpB family
K03695,K03696
-
-
0.00000000000000000005351
94.0
DEZH1_k127_8333005_30
Cell envelope-like function transcriptional attenuator common domain protein
-
-
-
0.0002405
44.0
DEZH1_k127_8333005_31
TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000001045
81.0
DEZH1_k127_8333005_7
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000003431
79.0
DEZH1_k127_8333005_8
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000003844
77.0
DEZH1_k127_8333005_9
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.00000000000005905
71.0
DEZH1_k127_8503219_0
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.000000000000000009884
83.0
DEZH1_k127_8503219_11
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0000000000000001943
79.0
DEZH1_k127_8503219_14
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0000000000000003878
81.0
DEZH1_k127_8503219_15
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0000000000000006159
78.0
DEZH1_k127_8503219_16
Zn-dependent protease with chaperone function
K03799,K06013
-
3.4.24.84
0.00000000000000106
76.0
DEZH1_k127_8503219_18
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.000000000000003879
77.0
DEZH1_k127_8503219_19
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
0.000000000000004192
75.0
DEZH1_k127_8503219_2
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.00000000000000000000000000003888
119.0
DEZH1_k127_8503219_20
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0000000000005426
70.0
DEZH1_k127_8503219_24
Psort location Cytoplasmic, score 8.96
K00963
-
2.7.7.9
0.0000000000005832
68.0
DEZH1_k127_8503219_25
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.000000000002084
67.0
DEZH1_k127_8503219_26
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
0.00000000007678
62.0
DEZH1_k127_8503219_3
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0000000001231
61.0
DEZH1_k127_8503219_32
CAAX prenyl protease N-terminal, five membrane helices
K03799,K06013
-
3.4.24.84
0.0000000001614
62.0
DEZH1_k127_8503219_33
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0000000004214
60.0
DEZH1_k127_8503219_35
Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
-
-
-
0.0000000008884
59.0
DEZH1_k127_8503219_36
COGs COG0501 Zn-dependent protease with chaperone function
K03799,K06013
-
3.4.24.84
0.0000000009836
59.0
DEZH1_k127_8503219_37
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.000000001861
58.0
DEZH1_k127_8503219_38
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COGs COG0501 Zn-dependent protease with chaperone function
K03799,K06013
-
3.4.24.84
0.00000001175
55.0
DEZH1_k127_8503219_43
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.00000001451
57.0
DEZH1_k127_8503219_44
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0000004734
52.0
DEZH1_k127_8503219_45
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.000004035
51.0
DEZH1_k127_8503219_49
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAAX prenyl protease N-terminal, five membrane helices
K03799,K06013
-
3.4.24.84
0.0002405
44.0
DEZH1_k127_8503219_61
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0002999
44.0
DEZH1_k127_8503219_62
Involved in the biosynthesis of porphyrin-containing compound
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0009726
42.0
DEZH1_k127_8503219_7
Histidine triad domain protein
K02503
-
-
0.0000000000000000000003616
97.0
DEZH1_k127_8503219_8
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.000000000000000000002207
96.0
DEZH1_k127_8503219_9
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
0.0000000000000000001673
88.0
DEZH1_k127_8536571_0
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
K03282
-
-
0.00000000000001229
75.0
DEZH1_k127_8638733_0
Psort location Cytoplasmic, score
-
-
-
0.000000000000000000000000000000007807
129.0
DEZH1_k127_8638733_1
Glycosyl transferase
-
-
-
0.0000000000000000000000000003151
115.0
DEZH1_k127_8638733_10
BRO family, N-terminal domain
K14623
-
-
0.0000000001788
62.0
DEZH1_k127_8638733_11
Mg chelatase-like protein
K07391
-
-
0.0000000003204
60.0
DEZH1_k127_8638733_12
PFAM LemA
K03744
-
-
0.000000001756
60.0
DEZH1_k127_8638733_13
transferase activity, transferring glycosyl groups
-
-
-
0.000000001938
59.0
DEZH1_k127_8638733_14
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
K07173
-
4.4.1.21
0.000000002824
57.0
DEZH1_k127_8638733_15
chelatase, subunit ChlI
K07391
-
-
0.000000006571
56.0
DEZH1_k127_8638733_16
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
K07173
-
4.4.1.21
0.000000006951
56.0
DEZH1_k127_8638733_17
Glycosyl transferases group 1
-
-
-
0.00000001333
56.0
DEZH1_k127_8638733_18
Glycosyltransferase Family 4
-
-
-
0.00000007278
55.0
DEZH1_k127_8638733_19
Protein of unknown function (DUF5131)
-
-
-
0.0000001811
53.0
DEZH1_k127_8638733_2
D12 class N6 adenine-specific DNA methyltransferase
K07318
-
2.1.1.72
0.00000000000000000000000001318
110.0
DEZH1_k127_8638733_20
Protein of unknown function (DUF3137)
-
-
-
0.0000002493
54.0
DEZH1_k127_8638733_21
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
0.000001835
49.0
DEZH1_k127_8638733_22
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
0.000006013
48.0
DEZH1_k127_8638733_23
Psort location Cytoplasmic, score 8.96
-
-
-
0.000006245
49.0
DEZH1_k127_8638733_24
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
K05946
-
2.4.1.187
0.000006704
49.0
DEZH1_k127_8638733_25
PFAM magnesium chelatase ChlI subunit
K07391
-
-
0.000006727
48.0
DEZH1_k127_8638733_26
D12 class N6 adenine-specific DNA methyltransferase
K07318
-
2.1.1.72
0.00003017
46.0
DEZH1_k127_8638733_27
PFAM LemA family protein
K03744
-
-
0.00003317
47.0
DEZH1_k127_8638733_28
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
0.00008226
45.0
DEZH1_k127_8638733_29
DNA polymerase III, delta
K02341
-
2.7.7.7
0.0001146
49.0
DEZH1_k127_8638733_3
chelatase, subunit ChlI
K07391
-
-
0.000000000000000000000004108
104.0
DEZH1_k127_8638733_30
Protein of unknown function (DUF5131)
-
-
-
0.000158
45.0
DEZH1_k127_8638733_31
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D12 class N6 adenine-specific DNA methyltransferase
K07318
-
2.1.1.72
0.0000000000000000000001313
97.0
DEZH1_k127_8638733_5
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
K07173
-
4.4.1.21
0.00000000000000000005568
89.0
DEZH1_k127_8638733_6
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
0.0000000000000000004961
87.0
DEZH1_k127_8638733_7
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01626
-
2.5.1.54
0.000000000000007947
74.0
DEZH1_k127_8638733_8
Protein of unknown function (DUF5131)
-
-
-
0.0000000000001222
72.0
DEZH1_k127_8638733_9
LemA family
K03744
-
-
0.0000000001046
63.0
DEZH1_k127_9330644_0
helicase activity
K03466,K12217
-
-
0.0000000000002909
70.0
DEZH1_k127_9330644_1
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.0000000000003999
70.0
DEZH1_k127_9330644_2
RNHCP domain
-
-
-
0.0000000004954
60.0
DEZH1_k127_9330644_3
COG0433 Predicted ATPase
-
-
-
0.000000003487
59.0
DEZH1_k127_9330644_4
-
-
-
-
0.00003119
51.0
DEZH1_k127_9330644_5
Activator of Hsp90 ATPase
-
-
-
0.00004098
46.0
DEZH1_k127_9330644_6
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.0001211
45.0
DEZH1_k127_9330644_7
Type IV secretion-system coupling protein DNA-binding domain
-
-
-
0.0001746
48.0
DEZH1_k127_9398536_0
ABC transporter
K06158
-
-
0.000000000002633
70.0
DEZH1_k127_9398536_1
ABC transporter
K06158
-
-
0.000000001774
59.0
DEZH1_k127_9398536_2
Belongs to the pseudouridine synthase RsuA family
K06183
-
5.4.99.19
0.00000006157
55.0
DEZH1_k127_9398536_3
ABC transporter
K06158
-
-
0.000001835
49.0
DEZH1_k127_9398536_5
ATPase components of ABC transporters with duplicated ATPase domains
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K03555
-
-
0.00000001106
59.0
DEZH1_k127_952479_1
Alternative locus ID
-
-
-
0.00000002486
56.0
DEZH1_k127_952479_2
Histidine kinase
-
-
-
0.0000004035
52.0
DEZH1_k127_952479_3
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
K03685
-
3.1.26.3
0.000001582
49.0
DEZH1_k127_952479_4
that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K03555
-
-
0.000009598
49.0
DEZH1_k127_952479_5
TIGRFAM DNA polymerase III, delta subunit
K02340
-
2.7.7.7
0.00009159
48.0
DEZH1_k127_952479_6
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
ATPases associated with a variety of cellular activities
K09812
-
-
0.0003855
43.0
DEZH1_k127_9606188_12
ATPases associated with a variety of cellular activities
K02049
-
-
0.0008741
42.0
DEZH1_k127_9606188_2
cell division ATP-binding protein FtsE
K09812
-
-
0.000000000000000008043
84.0
DEZH1_k127_9606188_3
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K02356
-
-
0.0000000000005034
71.0
DEZH1_k127_9606188_4
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10773
-
4.2.99.18
0.0000000000005317
70.0
DEZH1_k127_9606188_5
UPF0489 domain
-
-
-
0.000000000004667
70.0
DEZH1_k127_9606188_6
PFAM Cation H exchanger
K03316
-
-
0.0000000001271
69.0
DEZH1_k127_9606188_7
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
