Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K01491
-
1.5.1.5,3.5.4.9
0.00000000000002527
73.0
DEZH2_k127_1143182_11
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K00806
-
2.5.1.31
0.0000000000001194
75.0
DEZH2_k127_1143182_12
SNARE associated Golgi protein
-
-
-
0.0000000000005257
75.0
DEZH2_k127_1143182_13
Belongs to the FPP GGPP synthase family
K13789
-
2.5.1.1,2.5.1.10,2.5.1.29
0.000000000001965
68.0
DEZH2_k127_1143182_14
Required for disulfide bond formation in some proteins
K03611
-
-
0.000000000002485
71.0
DEZH2_k127_1143182_15
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)
Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K04564
-
1.15.1.1
0.00000000000000000000000000000000004844
135.0
DEZH2_k127_1143182_4
ZIP Zinc transporter
K07238
-
-
0.00000000000000000000000001986
118.0
DEZH2_k127_1143182_5
Cytochrome P450
-
-
-
0.00000000000000000000000002487
111.0
DEZH2_k127_1143182_6
endonuclease containing a URI domain
K07461
-
-
0.000000000000000000002595
95.0
DEZH2_k127_1143182_7
PFAM RNP-1 like RNA-binding protein
-
-
-
0.00000000000000007389
84.0
DEZH2_k127_1143182_8
This protein binds to 23S rRNA in the presence of protein L20
K02888
GO:0003674,GO:0003735,GO:0005198
-
0.0000000000000004784
82.0
DEZH2_k127_1143182_9
binds to the 23S rRNA
K02939
-
-
0.000000000000008146
81.0
DEZH2_k127_1668825_0
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
0.000000000000000000000000000103
116.0
DEZH2_k127_2083293_0
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K00969
-
2.7.7.18
0.000776
48.0
DEZH2_k127_2083293_2
antibiotic catabolic process
-
-
-
0.0000000000000000000000000000002404
131.0
DEZH2_k127_2083293_3
Malate dehydrogenase
K00027
-
1.1.1.38
0.00000000000000000000000000144
111.0
DEZH2_k127_2083293_4
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09765
-
1.17.99.6
0.000000000000000000000000002261
113.0
DEZH2_k127_2083293_5
queuosine biosynthetic process
K03470,K09765
-
1.17.99.6,3.1.26.4
0.000000000003055
72.0
DEZH2_k127_2083293_6
Produces ATP from ADP in the presence of a proton gradient across the membrane
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.00000000000000116
79.0
DEZH2_k127_2108037_3
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.000000000006706
66.0
DEZH2_k127_2120125_0
Belongs to the class-I aminoacyl-tRNA synthetase family
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
K00067
-
1.1.1.133
0.000000000000000001084
88.0
DEZH2_k127_2120125_41
Glycosyl transferases group 1
-
-
-
0.000000000000000002503
85.0
DEZH2_k127_2120125_42
Subtilase family
-
-
-
0.00000000000000000341
88.0
DEZH2_k127_2120125_43
Uncharacterised protein family UPF0052
-
-
-
0.0000000000000000109
85.0
DEZH2_k127_2120125_44
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K02963
-
-
0.00000000000000003459
85.0
DEZH2_k127_2120125_45
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
0.0000000000000000399
85.0
DEZH2_k127_2120125_46
Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K01711
-
4.2.1.47
0.0000000000000002815
78.0
DEZH2_k127_2120125_47
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
K03695,K03696
-
-
0.0000000000000003467
78.0
DEZH2_k127_2120125_48
Transcriptional regulatory protein, C terminal
-
-
-
0.0000000000000004199
79.0
DEZH2_k127_2120125_49
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.0000000000000007555
79.0
DEZH2_k127_2120125_5
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
0.0000004763
53.0
DEZH2_k127_2120125_73
COG3209 Rhs family protein
-
-
-
0.0000004776
58.0
DEZH2_k127_2120125_74
PspC domain
K03973
-
-
0.000000655
53.0
DEZH2_k127_2120125_75
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
0.000001029
52.0
DEZH2_k127_2120125_76
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
K00067
-
1.1.1.133
0.0000017
50.0
DEZH2_k127_2120125_77
Transcriptional regulator
K10947
-
-
0.000002438
49.0
DEZH2_k127_2120125_78
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
0.000008758
48.0
DEZH2_k127_2120125_79
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.000000000000000000001783
93.0
DEZH2_k127_3232988_12
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0000000000004144
71.0
DEZH2_k127_3232988_13
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K00600
-
2.1.2.1
0.000000000001275
67.0
DEZH2_k127_3232988_14
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.000005071
50.0
DEZH2_k127_3232988_23
DNA internalization competence protein ComEC Rec2-like protein
K02238
-
-
0.00001316
53.0
DEZH2_k127_3232988_24
Membrane-associated phospholipid phosphatase
-
-
-
0.00002322
58.0
DEZH2_k127_3232988_25
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.00000000000000000000000000000002725
126.0
DEZH2_k127_3232988_7
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K03701
-
-
0.000000000000000000000000001555
116.0
DEZH2_k127_3232988_8
Belongs to the peptidase S8 family
-
-
-
0.00000000000000000000000001176
114.0
DEZH2_k127_3232988_9
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.00000000000000000000000002864
108.0
DEZH2_k127_4161253_0
AAA domain
-
-
-
0.000000000000000000000000005599
113.0
DEZH2_k127_4161253_1
-
-
-
-
0.00000000000001925
76.0
DEZH2_k127_4161253_2
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
K03111
-
-
0.0000000002117
61.0
DEZH2_k127_4161253_3
dna polymerase iii
K10857
-
-
0.00000001257
60.0
DEZH2_k127_4161253_4
AAA domain
-
-
-
0.0000001691
52.0
DEZH2_k127_4161253_5
COG0847 DNA polymerase III epsilon subunit and related 3'-5'
K02342,K10857
-
2.7.7.7
0.000001657
51.0
DEZH2_k127_4161253_6
Domain of unknown function (DUF4373)
-
-
-
0.0008605
49.0
DEZH2_k127_4199442_0
COG0464 ATPases of the AAA class
K13525
-
-
0.000000000000000000000000000001745
125.0
DEZH2_k127_4199442_1
HD domain
K07023
-
-
0.000000000000000000000000006398
121.0
DEZH2_k127_4199442_2
ATPase activity
K13525
-
-
0.0000002499
53.0
DEZH2_k127_4199442_3
Mycobacterial 4 TMS phage holin, superfamily IV
K08972
-
-
0.0000004588
55.0
DEZH2_k127_4314577_0
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PFAM Penicillin binding protein transpeptidase domain
K05366
-
2.4.1.129,3.4.16.4
0.000000002665
61.0
DEZH2_k127_4581850_19
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K07738
-
-
0.0000000000000000000000000000000001517
138.0
DEZH2_k127_4581850_4
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
K02935
-
-
0.00000000000000000000000000000002905
130.0
DEZH2_k127_4581850_5
the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA
K03664
-
-
0.0000000000000000000000000000188
121.0
DEZH2_k127_4581850_6
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885,K09698
-
6.1.1.17,6.1.1.24
0.00000000005611
63.0
DEZH2_k127_4995636_114
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K17247
-
-
0.00000000007727
70.0
DEZH2_k127_4995636_115
HD domain
K07023
-
-
0.00000000008988
68.0
DEZH2_k127_4995636_116
-
-
-
-
0.0000000001107
67.0
DEZH2_k127_4995636_117
Type III restriction enzyme res subunit
K01156
-
3.1.21.5
0.0000000001115
62.0
DEZH2_k127_4995636_118
nuclear chromosome segregation
-
-
-
0.0000000001148
67.0
DEZH2_k127_4995636_119
Type III restriction enzyme, res subunit
K01156
-
3.1.21.5
0.0000000001237
66.0
DEZH2_k127_4995636_12
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0000000001998
61.0
DEZH2_k127_4995636_122
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
0.0000000004652
61.0
DEZH2_k127_4995636_123
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10773
-
4.2.99.18
0.0000000005569
61.0
DEZH2_k127_4995636_124
DNA methylase
K00571,K07316
-
2.1.1.72
0.000000002561
58.0
DEZH2_k127_4995636_125
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K07082
-
-
0.000000002753
65.0
DEZH2_k127_4995636_126
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K02834
-
-
0.000008682
53.0
DEZH2_k127_4995636_153
TM2 domain
-
-
-
0.00001723
51.0
DEZH2_k127_4995636_154
Tetratricopeptide repeat
-
-
-
0.00001723
51.0
DEZH2_k127_4995636_155
SNARE associated Golgi protein
K19302
-
3.6.1.27
0.00002014
52.0
DEZH2_k127_4995636_156
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme
protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
K00940
-
2.7.4.6
0.000000000000000000000000000000000000000008159
158.0
DEZH2_k127_4995636_36
COG2189 Adenine specific DNA methylase Mod
K07316
-
2.1.1.72
0.000000000000000000000000000000000000000009901
155.0
DEZH2_k127_4995636_37
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.00000000000000000000000000000000000000001104
156.0
DEZH2_k127_4995636_38
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
K01358
-
3.4.21.92
0.0000000000000000000000000000000000000002563
154.0
DEZH2_k127_4995636_39
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.0000000000000000000000000000000000000305
149.0
DEZH2_k127_4995636_4
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
0.0000000000000000000000000000000000244
141.0
DEZH2_k127_4995636_43
Belongs to the pirin family
K06911
-
-
0.000000000000000000000000000000001044
133.0
DEZH2_k127_4995636_44
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K07056
-
2.1.1.198
0.00000000000000000000000000000000131
132.0
DEZH2_k127_4995636_45
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000000000000000009402
114.0
DEZH2_k127_4995636_58
S-layer homology domain
-
-
-
0.000000000000000000000000002044
116.0
DEZH2_k127_4995636_59
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
K07642
-
2.7.13.3
0.000000000000000000000000002065
121.0
DEZH2_k127_4995636_6
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
K01358
-
3.4.21.92
0.000000000000000000000000003709
111.0
DEZH2_k127_4995636_61
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.00000000000000000000000001984
109.0
DEZH2_k127_4995636_62
DNA methylase
K07316
-
2.1.1.72
0.00000000000000000000000004641
111.0
DEZH2_k127_4995636_63
ATP-dependent DNA helicase
K03657
-
3.6.4.12
0.0000000000000000000000002078
108.0
DEZH2_k127_4995636_64
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
K02884
-
-
0.000000000000000000000001124
107.0
DEZH2_k127_4995636_65
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.00000000000000000000001015
111.0
DEZH2_k127_4995636_66
Methionine aminopeptidase
K01265
-
3.4.11.18
0.00000000000000000000001128
101.0
DEZH2_k127_4995636_67
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.0000000000000000000000196
104.0
DEZH2_k127_4995636_68
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885,K09698
-
6.1.1.17,6.1.1.24
0.00000000000000000000002447
106.0
DEZH2_k127_4995636_69
Fic/DOC family
-
-
-
0.00000000000000000000002622
102.0
DEZH2_k127_4995636_7
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
K01890
-
6.1.1.20
0.00000000000000002647
93.0
DEZH2_k127_4995636_9
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0000000000000001869
85.0
DEZH2_k127_4995636_92
PFAM cell divisionFtsK SpoIIIE
K03466
-
-
0.0000000000000004062
80.0
DEZH2_k127_4995636_93
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
K01749
-
2.5.1.61
0.000000000000000000000000000002501
124.0
DEZH2_k127_5047757_33
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K00791
-
2.5.1.75
0.00000000000000000000000000008603
117.0
DEZH2_k127_5047757_34
Protein of unknown function (DUF1361)
-
-
-
0.0000000000000000000000000008905
121.0
DEZH2_k127_5047757_35
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.000000000000000000000000006322
113.0
DEZH2_k127_5047757_36
-
-
-
-
0.0000000000000000000000003371
108.0
DEZH2_k127_5047757_37
Protein conserved in bacteria
-
-
-
0.0000000000000000000000004569
104.0
DEZH2_k127_5047757_38
PFAM Membrane protein of
K08972
-
-
0.00000000000000000000003736
102.0
DEZH2_k127_5047757_39
Specifically methylates the N7 position of a guanine in 16S rRNA
transferase activity, transferring glycosyl groups
-
-
-
0.00000000000000000007624
96.0
DEZH2_k127_5047757_43
Elongator protein 3, MiaB family, Radical SAM
-
-
-
0.000000000000000000169
91.0
DEZH2_k127_5047757_44
TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain
K01905,K22224
-
6.2.1.13
0.0000000000000000002776
91.0
DEZH2_k127_5047757_45
PFAM Plasmid stabilisation system
-
-
-
0.000000000000000006066
86.0
DEZH2_k127_5047757_46
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.000000000000000007569
83.0
DEZH2_k127_5047757_47
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K00567,K10778
-
2.1.1.63
0.00000000000000001112
82.0
DEZH2_k127_5047757_48
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
K01749
-
2.5.1.61
0.00000000000000001139
85.0
DEZH2_k127_5047757_49
exonuclease
K07462
-
-
0.00000000000000002303
86.0
DEZH2_k127_5047757_5
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.0000000000003594
73.0
DEZH2_k127_5047757_61
PhnA domain
K06193
-
-
0.000000000001599
67.0
DEZH2_k127_5047757_62
GIY-YIG catalytic domain protein
K07461
-
-
0.000000000001752
68.0
DEZH2_k127_5047757_63
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K00567
-
2.1.1.63
0.000000000001977
67.0
DEZH2_k127_5047757_64
Protein of unknown function (DUF4256)
-
-
-
0.000000000004557
65.0
DEZH2_k127_5047757_65
Belongs to the anaerobic coproporphyrinogen-III oxidase family
-
-
-
0.000000000009711
65.0
DEZH2_k127_5047757_66
Specifically methylates the N7 position of a guanine in 16S rRNA
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.0000000001312
62.0
DEZH2_k127_5047757_72
PFAM CoA-binding domain protein
K01905,K22224
-
6.2.1.13
0.0000000002419
62.0
DEZH2_k127_5047757_73
Uroporphyrinogen-III synthase
K01719
-
4.2.1.75
0.000000002863
61.0
DEZH2_k127_5047757_74
Catalyzes the ferrous insertion into protoporphyrin IX
K01772
-
4.99.1.1,4.99.1.9
0.000000003151
59.0
DEZH2_k127_5047757_75
CHASE
-
-
-
0.000000005857
58.0
DEZH2_k127_5047757_76
Protein of unknown function (DUF4256)
-
-
-
0.00000001131
56.0
DEZH2_k127_5047757_77
Belongs to the MurCDEF family
K01924
-
6.3.2.8
0.00000003902
57.0
DEZH2_k127_5047757_78
Protein of unknown function (DUF4256)
-
-
-
0.00000007531
53.0
DEZH2_k127_5047757_79
ATP-grasp domain
K01905,K22224
-
6.2.1.13
0.0000000851
61.0
DEZH2_k127_5047757_8
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
transferase activity, transferring glycosyl groups
-
-
-
0.000009081
50.0
DEZH2_k127_5047757_86
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.000009161
49.0
DEZH2_k127_5047757_87
Putative diguanylate phosphodiesterase
-
-
-
0.000009607
47.0
DEZH2_k127_5047757_88
Protein of unknown function (DUF1501)
-
-
-
0.00001113
57.0
DEZH2_k127_5047757_89
Phosphotransferase enzyme family
-
-
-
0.0000171
48.0
DEZH2_k127_5047757_9
Pyruvate ferredoxin oxidoreductase beta subunit C terminal
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0000000000000000000000000001468
115.0
DEZH2_k127_549883_12
recombinase XerD
K04763
-
-
0.000000000000000000000001608
107.0
DEZH2_k127_549883_13
COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
-
-
-
0.00000000000000000000004695
102.0
DEZH2_k127_549883_14
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K03086
-
-
0.0004217
42.0
DEZH2_k127_549883_44
Cellulase (glycosyl hydrolase family 5)
K01179
-
3.2.1.4
0.0006343
43.0
DEZH2_k127_549883_5
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0000000000000000000000000000000000000000002958
172.0
DEZH2_k127_549883_6
Extradiol ring-cleavage dioxygenase
K15777
-
-
0.0000000000000000000000000000000000000001737
156.0
DEZH2_k127_549883_7
DNA polymerase III, alpha subunit
K02337,K14162
-
2.7.7.7
0.0000000000000000000000000000000000000002876
161.0
DEZH2_k127_549883_8
Acetyltransferase (GNAT) domain
K07023
-
-
0.00000000000000000000000000000000008451
134.0
DEZH2_k127_549883_9
Belongs to the DEAD box helicase family
K11927
-
3.6.4.13
0.000000000000000000000000000000001145
141.0
DEZH2_k127_5542618_0
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03043
-
2.7.7.6
0.0
1097.0
DEZH2_k127_5542618_1
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K03046
-
2.7.7.6
5.12e-301
953.0
DEZH2_k127_5542618_10
Virulence protein RhuM family
-
-
-
0.000000000000000000000000000000000000000007654
158.0
DEZH2_k127_5542618_11
-
-
-
-
0.00000000000000000000000000000000000000002851
155.0
DEZH2_k127_5542618_12
AcrB/AcrD/AcrF family
-
-
-
0.0000000000000000000000000000000000000003546
157.0
DEZH2_k127_5542618_13
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
0.00000000000000000000000000000000000001253
151.0
DEZH2_k127_5542618_14
-
-
-
-
0.0000000000000000000000000000000000002183
147.0
DEZH2_k127_5542618_15
ATPase family associated with various cellular activities (AAA)
K03924
-
-
0.0000000000000000000000000000000000007974
144.0
DEZH2_k127_5542618_16
PFAM Adenylate and Guanylate cyclase catalytic domain
K01768
-
4.6.1.1
0.0000000000000000000000000000000001397
143.0
DEZH2_k127_5542618_17
Multicopper oxidase
-
-
-
0.0000000000000000000000000000000009934
131.0
DEZH2_k127_5542618_18
helix_turn_helix multiple antibiotic resistance protein
-
-
-
0.0000000000000000000000000001357
119.0
DEZH2_k127_5542618_19
PFAM peptidase U32
K08303
-
-
0.00000000000000000000000002484
111.0
DEZH2_k127_5542618_2
Threonine synthase
K01733
-
4.2.3.1
2.97e-239
747.0
DEZH2_k127_5542618_20
Possible lysine decarboxylase
K06966
-
3.2.2.10
0.0000000000000000000000001151
108.0
DEZH2_k127_5542618_21
ATPase family associated with various cellular activities (AAA)
K03924
-
-
0.0000000000000000000001071
97.0
DEZH2_k127_5542618_22
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K03648
-
3.2.2.27
0.000000000000000000001225
94.0
DEZH2_k127_5542618_23
DNA alkylation repair enzyme
-
-
-
0.00000000000000000004218
91.0
DEZH2_k127_5542618_24
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.00000000000000000007956
90.0
DEZH2_k127_5542618_26
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.0000000000000000004338
87.0
DEZH2_k127_5542618_27
Integral membrane protein TerC family
-
-
-
0.000000000000000004397
86.0
DEZH2_k127_5542618_28
Uncharacterized protein conserved in bacteria (DUF2130)
-
-
-
0.00000000000000002933
82.0
DEZH2_k127_5542618_29
COG0607 Rhodanese-related sulfurtransferase
-
-
-
0.0000000000000000427
85.0
DEZH2_k127_5542618_3
Evidence 5 No homology to any previously reported sequences
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
-
-
-
0.00000000006495
70.0
DEZH2_k127_5542618_41
DNA alkylation repair enzyme
-
-
-
0.00000000008091
64.0
DEZH2_k127_5542618_42
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.0005704
48.0
DEZH2_k127_5542618_7
sh3 domain protein
-
-
-
0.0000000000000000000000000000000000000000003651
166.0
DEZH2_k127_5542618_8
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K03648
-
3.2.2.27
0.0000000000000000000000000000000000000000004656
160.0
DEZH2_k127_5542618_9
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
0.000000000000000000000000000000000000000001194
160.0
DEZH2_k127_5796311_0
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K02986
-
-
0.000000000000000000000000000000000000000001567
163.0
DEZH2_k127_5796311_13
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K02871
-
-
0.00000000000000000000000000000000000000339
151.0
DEZH2_k127_5796311_14
TIGRFAM stage V sporulation protein D
K03587,K08384
-
3.4.16.4
0.00000000000000000000000000000000000002
151.0
DEZH2_k127_5796311_15
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K02952
-
-
0.0000000000000000000000000000000000002691
143.0
DEZH2_k127_5796311_16
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
K02992
-
-
0.0000000000000000000000000000000000006732
144.0
DEZH2_k127_5796311_17
4Fe-4S single cluster domain
-
-
-
0.000000000000000000000000000000000001495
145.0
DEZH2_k127_5796311_18
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.0000000000000000000000000000000002579
138.0
DEZH2_k127_5796311_19
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Responsible for synthesis of pseudouridine from uracil
K06179
-
5.4.99.24
0.000000000000000001156
90.0
DEZH2_k127_5796311_31
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity
K03581
-
3.1.11.5
0.00000000005706
64.0
DEZH2_k127_5796311_44
Efflux ABC transporter permease protein
K02004
-
-
0.0000000000824
64.0
DEZH2_k127_5796311_45
-
-
-
-
0.00000000008395
68.0
DEZH2_k127_5796311_46
Anaerobic ribonucleoside-triphosphate reductase
-
-
-
0.00000000008871
64.0
DEZH2_k127_5796311_47
rRNA methylase
K06442
-
2.1.1.226,2.1.1.227
0.0000000001393
64.0
DEZH2_k127_5796311_48
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
K01056
-
3.1.1.29
0.0000000004463
62.0
DEZH2_k127_5796311_49
Belongs to the peptidase S8 family
-
-
-
0.000000001247
71.0
DEZH2_k127_5796311_5
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
0.00000001488
56.0
DEZH2_k127_5796311_52
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K03625
-
-
0.00000004609
59.0
DEZH2_k127_5796311_53
Sigma-70 factor, region 1.2
K03086
-
-
0.0000003277
62.0
DEZH2_k127_5796311_54
Type II/IV secretion system protein
K02669
-
-
0.000001129
53.0
DEZH2_k127_5796311_55
COG0577 ABC-type antimicrobial peptide transport system permease component
K02004
-
-
0.000001563
53.0
DEZH2_k127_5796311_56
Responsible for synthesis of pseudouridine from uracil
K06180
-
5.4.99.23
0.000002107
52.0
DEZH2_k127_5796311_57
Penicillin-binding protein, dimerisation domain
K03587
-
3.4.16.4
0.00000377
49.0
DEZH2_k127_5796311_58
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Belongs to the small heat shock protein (HSP20) family
K13993
-
-
0.00001497
53.0
DEZH2_k127_5796311_62
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
0.00005449
52.0
DEZH2_k127_5796311_63
4Fe-4S single cluster domain
K06871
-
-
0.0000568
48.0
DEZH2_k127_5796311_64
PFAM TPR repeat-containing protein
-
-
-
0.000122
50.0
DEZH2_k127_5796311_65
Cell division protein FtsI penicillin-binding protein 2
K03587
-
3.4.16.4
0.0001757
52.0
DEZH2_k127_5796311_66
Belongs to the bacterial ribosomal protein bL17 family
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000000000000000007193
133.0
DEZH2_k127_6124292_11
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000001394
96.0
DEZH2_k127_6124292_12
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K03655
-
3.6.4.12
0.0000000000000000007824
88.0
DEZH2_k127_6124292_13
bacterioferritin comigratory protein
K03564
-
1.11.1.15
0.000000000000000002171
89.0
DEZH2_k127_6124292_14
PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K03564
-
1.11.1.15
0.000000000000002197
76.0
DEZH2_k127_6124292_15
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0002909
51.0
DEZH2_k127_6124292_4
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000000000000005709
85.0
DEZH2_k127_6366264_12
Thioredoxin
-
-
-
0.000000000000000178
89.0
DEZH2_k127_6366264_13
Belongs to the class-II aminoacyl-tRNA synthetase family
K04567,K04568
-
6.1.1.6
0.00000000000001812
74.0
DEZH2_k127_6366264_14
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.000000000000111
74.0
DEZH2_k127_6366264_15
PFAM tRNA synthetases class II (D, K and N)
K04567
-
6.1.1.6
0.0000000003034
68.0
DEZH2_k127_6366264_16
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000002041
57.0
DEZH2_k127_6366264_17
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
K04075
-
6.3.4.19
0.00000003488
55.0
DEZH2_k127_6366264_18
Excalibur calcium-binding domain
K01174
-
3.1.31.1
0.0003873
51.0
DEZH2_k127_6366264_19
Peptidase M48
-
-
-
0.0005491
44.0
DEZH2_k127_6366264_2
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
K03734
-
2.7.1.180
0.000000000000000000000000002472
115.0
DEZH2_k127_6654170_11
L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp
K01876
-
6.1.1.12
0.000000000000000000000000007703
111.0
DEZH2_k127_6654170_12
Sigma-70, region 4
K03088
-
-
0.00000000000000000000000001745
114.0
DEZH2_k127_6654170_13
ABC transporter
K06158
-
-
0.00000000000000000000003837
103.0
DEZH2_k127_6654170_14
Beta propeller domain
-
-
-
0.00000000000000000000004356
104.0
DEZH2_k127_6654170_15
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0000000000000000000008156
97.0
DEZH2_k127_6654170_16
Pyridine nucleotide-disulphide oxidoreductase
K05297
-
1.18.1.1
0.00000000000000000002015
94.0
DEZH2_k127_6654170_17
Belongs to the bacterial ribosomal protein bL28 family
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0000000004979
63.0
DEZH2_k127_6654170_23
Belongs to the NqrB RnfD family
-
-
-
0.0000000006137
61.0
DEZH2_k127_6654170_24
Oxidoreductase NAD-binding domain
K02613
-
-
0.000000001061
64.0
DEZH2_k127_6654170_25
peptidoglycan binding
K03642
-
-
0.00000002255
59.0
DEZH2_k127_6654170_26
ABC transporter, ATP-binding protein
K06158
-
-
0.00000005122
56.0
DEZH2_k127_6654170_27
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.000000000000000000000000000000000007733
143.0
DEZH2_k127_6654170_6
Involved in the binding of tRNA to the ribosomes
K02946
-
-
0.000000000000000000000000000009562
121.0
DEZH2_k127_6654170_7
ABC transporter
-
-
-
0.00000000000000000000000000002954
127.0
DEZH2_k127_6654170_8
-
-
-
-
0.0000000000000000000000000000788
116.0
DEZH2_k127_6654170_9
-
-
-
-
0.000000000000000000000000001874
112.0
DEZH2_k127_6668412_0
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
K01462
-
3.5.1.88
0.00000000006764
64.0
DEZH2_k127_6668412_104
Belongs to the class-I aminoacyl-tRNA synthetase family
helix_turn_helix, arabinose operon control protein
-
-
-
0.00000001601
61.0
DEZH2_k127_6668412_121
COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
K02236,K02654
-
3.4.23.43
0.00000001766
57.0
DEZH2_k127_6668412_122
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K09747
-
-
0.00000002012
59.0
DEZH2_k127_6668412_123
PFAM PKD domain containing protein
-
-
-
0.00000002161
57.0
DEZH2_k127_6668412_124
the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.00000004086
57.0
DEZH2_k127_6668412_126
PDZ domain (Also known as DHR or GLGF)
K08372
-
-
0.00000004619
60.0
DEZH2_k127_6668412_127
NUDIX domain
K03574
-
3.6.1.55
0.00000005475
61.0
DEZH2_k127_6668412_128
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K02563
-
2.4.1.227
0.000001858
51.0
DEZH2_k127_6668412_144
EamA-like transporter family
-
-
-
0.000002135
52.0
DEZH2_k127_6668412_145
Domain of unknown function (DUF4105)
-
-
-
0.00000217
51.0
DEZH2_k127_6668412_146
Involved in the biosynthesis of porphyrin-containing compound
-
-
-
0.000002823
52.0
DEZH2_k127_6668412_147
AAA domain, putative AbiEii toxin, Type IV TA system
K01990
-
-
0.000004603
51.0
DEZH2_k127_6668412_148
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K03665
-
-
0.000005307
51.0
DEZH2_k127_6668412_149
TIGRFAM Bacterial surface protein 26-residue repeat
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.000009229
49.0
DEZH2_k127_6668412_154
Belongs to the N-Me-Phe pilin family
K02650
-
-
0.00000958
53.0
DEZH2_k127_6668412_155
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
0.0000102
49.0
DEZH2_k127_6668412_156
Addiction module toxin RelE StbE family
-
-
-
0.00001045
51.0
DEZH2_k127_6668412_157
Bacterial Peptidase A24 N-terminal domain
K02654
-
3.4.23.43
0.00001206
47.0
DEZH2_k127_6668412_158
Type II secretion system (T2SS), protein F
K02653
-
-
0.00001507
49.0
DEZH2_k127_6668412_159
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COG2931, RTX toxins and related Ca2 -binding proteins
-
-
-
0.00001639
54.0
DEZH2_k127_6668412_161
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
helicase involved in DNA repair and perhaps also replication
K02342,K03722
-
2.7.7.7,3.6.4.12
0.0001259
48.0
DEZH2_k127_6668412_176
Arginyl-tRNA synthetase
K01887
-
6.1.1.19
0.0001269
48.0
DEZH2_k127_6668412_177
Methicillin resistance protein
-
-
-
0.0001945
46.0
DEZH2_k127_6668412_178
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03470
-
3.1.26.4
0.0002405
44.0
DEZH2_k127_6668412_179
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
0.0003166
44.0
DEZH2_k127_6668412_182
Belongs to the peptidase S8 family
K01176,K13730,K13735,K20276
-
3.2.1.1
0.0003166
44.0
DEZH2_k127_6668412_183
S-layer domain protein
K01181
-
3.2.1.8
0.0003847
46.0
DEZH2_k127_6668412_184
CYTH domain
K05873
-
4.6.1.1
0.0004026
45.0
DEZH2_k127_6668412_185
Signal peptidase, peptidase S26
K03100
-
3.4.21.89
0.0005888
46.0
DEZH2_k127_6668412_186
methyltransferase
-
-
-
0.0006429
45.0
DEZH2_k127_6668412_187
Cell cycle protein
K03588
-
-
0.0007487
45.0
DEZH2_k127_6668412_188
DNA-directed DNA polymerase activity
K02342,K03657,K03763
-
2.7.7.7,3.6.4.12
0.0007563
44.0
DEZH2_k127_6668412_189
Peptidase_C39 like family
-
-
-
0.0007567
47.0
DEZH2_k127_6668412_19
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.0009165
42.0
DEZH2_k127_6668412_2
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.000000000000000000000000000000000000008534
150.0
DEZH2_k127_6668412_25
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
K03282
-
-
0.00000000000000000000000000000000000001372
147.0
DEZH2_k127_6668412_26
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.00000000000000000000000000000000000002265
147.0
DEZH2_k127_6668412_27
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.00000000000000000000000000000000000005097
146.0
DEZH2_k127_6668412_28
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
0.00000000000000000000000000000000000008654
151.0
DEZH2_k127_6668412_29
SNARE associated Golgi protein
-
-
-
0.0000000000000000000000000000000000001249
147.0
DEZH2_k127_6668412_3
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
-
-
-
0.0000000000000000000000000000000000004904
145.0
DEZH2_k127_6668412_34
AAA ATPase
-
-
-
0.0000000000000000000000000000000000007334
140.0
DEZH2_k127_6668412_35
PFAM type II secretion system
K02653
-
-
0.000000000000000000000000000000000001824
145.0
DEZH2_k127_6668412_36
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K01159
-
3.1.22.4
0.000000000000000000000000000000000006298
140.0
DEZH2_k127_6668412_38
AAA domain
K07133
-
-
0.000000000000000000000000000000000006675
139.0
DEZH2_k127_6668412_39
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
0.00000000000000000000000000000000002883
136.0
DEZH2_k127_6668412_4
TIGRFAM Bacterial surface protein 26-residue repeat
Threonyl and Alanyl tRNA synthetase second additional domain
-
-
-
0.0000000000000000000000000000000004442
132.0
DEZH2_k127_6668412_43
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K03168
-
5.99.1.2
0.00000000000000000000000000000000338
132.0
DEZH2_k127_6668412_44
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K02897
-
-
0.000000000000000000000000000003695
127.0
DEZH2_k127_6668412_49
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K02563
-
2.4.1.227
0.00000000000000000000000006309
115.0
DEZH2_k127_6668412_54
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Catalyzes the reversible phosphorylation of UMP to UDP
K09903
-
2.7.4.22
0.00000000000000000000000587
103.0
DEZH2_k127_6668412_57
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ABC-type multidrug transport system ATPase and permease
K06147
-
-
0.00000000000000000000005511
99.0
DEZH2_k127_6668412_61
Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K03470
-
3.1.26.4
0.0000000000000000000001675
99.0
DEZH2_k127_6668412_62
ABC transporter, transmembrane region
K06147
-
-
0.0000000000000000000001995
97.0
DEZH2_k127_6668412_63
Glyoxalase
-
-
-
0.0000000000000000000002
100.0
DEZH2_k127_6668412_64
Belongs to the RNA methyltransferase TrmD family
K00554
-
2.1.1.228
0.000000000000000000001032
96.0
DEZH2_k127_6668412_65
PFAM aminoacyl-tRNA synthetase class Ib
K01867
-
6.1.1.2
0.000000000000000000002186
100.0
DEZH2_k127_6668412_66
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.000000000000000162
81.0
DEZH2_k127_6668412_79
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
0.0000000000000007036
79.0
DEZH2_k127_6668412_8
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
-
-
-
0.000000000003819
71.0
DEZH2_k127_6668412_94
Belongs to the class-I aminoacyl-tRNA synthetase family
K01867
-
6.1.1.2
0.000000000005079
68.0
DEZH2_k127_6668412_95
Belongs to the RNA methyltransferase TrmD family
K00554
-
2.1.1.228
0.000000000006984
68.0
DEZH2_k127_6668412_96
ABC transporter
K02003
-
-
0.00000000001051
67.0
DEZH2_k127_6668412_97
CYTH domain
K05873
-
4.6.1.1
0.00000000001913
69.0
DEZH2_k127_6668412_98
Psort location Cytoplasmic, score 8.96
K04096
-
-
0.00000000002079
68.0
DEZH2_k127_6668412_99
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
K01462
-
3.5.1.88
0.00000000002386
69.0
DEZH2_k127_6856784_0
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
0.000000000000000000000000000000000000009401
151.0
DEZH2_k127_6856784_4
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
-
-
-
0.0000000000000000000000000000000011
136.0
DEZH2_k127_6856784_5
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
0.00000000000000000000002404
104.0
DEZH2_k127_6957839_5
D-alanyl-D-alanine carboxypeptidase
-
-
-
0.00000000000000000004248
98.0
DEZH2_k127_6957839_6
Cytochrome C biogenesis protein transmembrane region
-
-
-
0.0000000000000000003599
89.0
DEZH2_k127_6957839_7
Predicted permease
K07089
-
-
0.00000000000000005742
80.0
DEZH2_k127_6957839_8
Transporter
K16264
-
-
0.0000000000000006976
79.0
DEZH2_k127_6957839_9
cation diffusion facilitator family transporter
K16264
-
-
0.00000000000003301
73.0
DEZH2_k127_7160001_0
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K02965
-
-
0.000000000000000000000000000000003118
129.0
DEZH2_k127_7160001_13
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K02890
-
-
0.0000000000000000000007736
98.0
DEZH2_k127_7160001_19
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
0.000000000000000000004037
96.0
DEZH2_k127_7160001_2
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.0000000000004866
72.0
DEZH2_k127_7160001_27
5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
-
-
-
0.000000005257
60.0
DEZH2_k127_7160001_28
Belongs to the Fur family
K03711,K09825
-
-
0.00000005045
60.0
DEZH2_k127_7160001_29
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
K02528
-
2.1.1.182
0.0000003267
55.0
DEZH2_k127_7160001_3
AAA domain, putative AbiEii toxin, Type IV TA system
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
K02493
-
2.1.1.297
0.000000000000000000000000001815
121.0
DEZH2_k127_727321_3
Psort location CytoplasmicMembrane, score 10.00
-
-
-
0.000000000000000000005187
100.0
DEZH2_k127_727321_4
EamA-like transporter family
-
-
-
0.0000000000000003087
82.0
DEZH2_k127_727321_5
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
0.000000000211
61.0
DEZH2_k127_727321_6
Belongs to the CDP-alcohol phosphatidyltransferase class-I family
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K00951
-
2.7.6.5
0.00000645
52.0
DEZH2_k127_727321_8
NUDIX domain
-
-
-
0.000009598
49.0
DEZH2_k127_727321_9
Vitamin K epoxide reductase family
-
-
-
0.00008383
51.0
DEZH2_k127_804295_0
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K03798
-
-
0.000000000000000000000000000000000744
136.0
DEZH2_k127_804295_5
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686,K05516
-
-
0.000000000000000000000517
96.0
DEZH2_k127_804295_8
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
3.898e-270
849.0
DEZH2_k127_8365374_1
Participates in both transcription termination and antitermination
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
-
-
-
0.000000000000000000001534
97.0
DEZH2_k127_8365374_13
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K03215
-
2.1.1.190
0.0000000000000003587
82.0
DEZH2_k127_8365374_16
Psort location CytoplasmicMembrane, score 9.82
K03748
-
-
0.000000000000002219
76.0
DEZH2_k127_8365374_17
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K03215
-
2.1.1.190
0.000000000000000000000000000000000000007812
149.0
DEZH2_k127_8365374_7
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
0.00000000000000000000000000000003608
132.0
DEZH2_k127_8365374_8
NOL1 NOP2 sun family
-
-
-
0.000000000000000000000000000006986
125.0
DEZH2_k127_8365374_9
aminopeptidase
K01262
-
3.4.11.9
0.000000000000000000000004061
102.0
DEZH2_k127_8448785_0
GTP-binding protein TypA
K06207
-
-
3.215e-211
675.0
DEZH2_k127_8448785_1
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.00000000000000000000000000000000001185
138.0
DEZH2_k127_8448785_6
Belongs to the N(4) N(6)-methyltransferase family
K00571,K00590
-
2.1.1.113,2.1.1.72
0.0000000000000000000000000000000004751
131.0
DEZH2_k127_8448785_7
Type II restriction endonuclease EcoO109I
-
-
-
0.000000000000000000000000000004125
120.0
DEZH2_k127_8448785_8
N-4 methylation of cytosine
K00571,K00590
-
2.1.1.113,2.1.1.72
0.0000000000000000000001803
97.0
DEZH2_k127_8448785_9
Type II restriction endonuclease EcoO109I
-
-
-
0.000000000000000003852
86.0
DEZH2_k127_9269082_0
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.00000000000001837
80.0
DEZH2_k127_9269082_18
TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K02115
-
-
0.00000000001197
68.0
DEZH2_k127_9269082_21
Domain of unknown function (DUF4143)
K07133
-
-
0.0000000002291
71.0
DEZH2_k127_9269082_22
Penicillin-binding protein 1A
K05366,K21464
-
2.4.1.129,3.4.16.4
0.0000000005179
67.0
DEZH2_k127_9269082_23
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K06187
-
-
0.0000000007082
61.0
DEZH2_k127_9269082_24
Pfam Proprotein convertase
-
-
-
0.0000000007448
61.0
DEZH2_k127_9269082_25
Phosphoglycerate mutase family
K08296
-
-
0.000000005217
64.0
DEZH2_k127_9269082_26
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
0.00000002919
59.0
DEZH2_k127_9269082_27
TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family
-
-
-
0.00000003742
61.0
DEZH2_k127_9269082_28
Insecticidal toxin complex protein TcaC
-
-
-
0.00000005923
55.0
DEZH2_k127_9269082_29
penicillin-binding protein
K03693,K12551
-
2.4.1.129
0.0000001354
54.0
DEZH2_k127_9269082_3
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K02115
-
-
0.00000000000000000000000000000000114
138.0
DEZH2_k127_9269082_8
OST-HTH/LOTUS domain
-
-
-
0.00000000000000000000000000000001402
128.0
DEZH2_k127_9269082_9
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K06187
-
-
0.000000000000000000000000000001641
124.0
DEZH2_k127_9665589_0
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.000000000000000000000000000000004862
131.0
DEZH2_k127_9665589_13
PFAM sugar transferase
-
-
-
0.00000000000000000000000000000001504
129.0
DEZH2_k127_9665589_14
ABC transporter
-
-
-
0.0000000000000000000000000004406
118.0
DEZH2_k127_9665589_15
COG0488 ATPase components of ABC transporters with duplicated ATPase domains
K06158
-
-
0.0000000000000000000000000543
113.0
DEZH2_k127_9665589_16
Beta-lactamase
K17836
-
3.5.2.6
0.0000000000000000000001696
103.0
DEZH2_k127_9665589_17
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K13292
-
-
0.0000000000000000753
83.0
DEZH2_k127_9665589_23
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.00000000004284
64.0
DEZH2_k127_9665589_28
Hep Hag repeat protein
-
-
-
0.00000000004471
68.0
DEZH2_k127_9665589_29
Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K13292
-
-
0.0000000000468
64.0
DEZH2_k127_9665589_3
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04485
-
-
0.000000000414
61.0
DEZH2_k127_9665589_34
DNA polymerase III
K02341
-
2.7.7.7
0.000000000811
65.0
DEZH2_k127_9665589_35
Type II/IV secretion system protein
K02669
-
-
0.000000001537
63.0
DEZH2_k127_9665589_37
COG3209 Rhs family protein
-
-
-
0.00000001112
60.0
DEZH2_k127_9665589_38
Beta-lactamase
K17836
-
3.5.2.6
0.0000000351
58.0
DEZH2_k127_9665589_39
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ABC-type multidrug transport system, ATPase and permease components
K06148
-
-
0.000007112
48.0
DEZH2_k127_9665589_44
Capsular polysaccharide biosynthesis protein
K20997
-
-
0.000007993
53.0
DEZH2_k127_9665589_45
surface antigen
-
-
-
0.00001259
55.0
DEZH2_k127_9665589_46
peptidase
-
-
-
0.00002668
51.0
DEZH2_k127_9665589_48
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.00005465
50.0
DEZH2_k127_9665589_49
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.00007475
49.0
DEZH2_k127_9665589_5
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.00008775
46.0
DEZH2_k127_9665589_51
hydrolase, TatD family
K03424
-
-
0.0005061
44.0
DEZH2_k127_9665589_52
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
K01929
-
6.3.2.10
0.0005206
47.0
DEZH2_k127_9665589_6
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K02356
-
-
0.0000000000000000000000000000000000000005845
156.0
DEZH2_k127_9706785_10
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K02887
-
-
0.0000000000000000000000005566
108.0
DEZH2_k127_9706785_11
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0000000000000000004133
91.0
DEZH2_k127_9706785_15
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K18707
-
2.8.4.5
0.00000000000000003291
87.0
DEZH2_k127_9706785_16
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.0000000000000001024
80.0
DEZH2_k127_9706785_17
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.0000000000000001436
82.0
DEZH2_k127_9706785_18
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Radical SAM methylthiotransferase, MiaB RimO family
K18707
-
2.8.4.5
0.000000003503
60.0
DEZH2_k127_9706785_33
COG COG3451 Type IV secretory pathway, VirB4 components
-
-
-
0.000000005706
59.0
DEZH2_k127_9706785_34
chelatase, subunit ChlI
K07391
-
-
0.00000001079
58.0
DEZH2_k127_9706785_35
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
K00384
-
1.8.1.9
0.00000001249
57.0
DEZH2_k127_9706785_36
NUDIX domain
-
-
-
0.00000002573
58.0
DEZH2_k127_9706785_37
TIGRFAM polysaccharide pyruvyl transferase CsaB
-
-
-
0.00000003922
61.0
DEZH2_k127_9706785_38
ErfK YbiS YcfS YnhG family protein
-
-
-
0.0000001062
55.0
DEZH2_k127_9706785_39
PFAM magnesium chelatase
K07391
-
-
0.0000001181
54.0
DEZH2_k127_9706785_4
helicase activity
-
-
-
0.000000000000000000000000000000000000005488
153.0
DEZH2_k127_9706785_40
chelatase subunit ChlI
K07391
-
-
0.0000001465
53.0
DEZH2_k127_9706785_41
Type IV pilus biogenesis protein
K02655
-
-
0.0000001897
53.0
DEZH2_k127_9706785_42
PFAM magnesium chelatase
K07391
-
-
0.0000002018
53.0
DEZH2_k127_9706785_43
Binds directly to 16S ribosomal RNA
K02968
-
-
0.0000002535
56.0
DEZH2_k127_9706785_44
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
0.0000002627
59.0
DEZH2_k127_9706785_45
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
0.000000341
55.0
DEZH2_k127_9706785_46
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.000000784
53.0
DEZH2_k127_9706785_47
diguanylate cyclase
-
-
-
0.0000008032
55.0
DEZH2_k127_9706785_48
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.000001046
53.0
DEZH2_k127_9706785_49
diguanylate cyclase
K02488
-
2.7.7.65
0.00000294
52.0
DEZH2_k127_9706785_5
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072,K12257
-
-
0.00000000000000000000000000000000000001404
156.0
DEZH2_k127_9706785_50
O-Antigen ligase
-
-
-
0.000003484
53.0
DEZH2_k127_9706785_51
Belongs to the UPF0235 family
K09131
-
-
0.000006007
51.0
DEZH2_k127_9706785_52
Belongs to the ompA family
K20276
-
-
0.000007244
58.0
DEZH2_k127_9706785_54
antibiotic catabolic process
-
-
-
0.0000441
51.0
DEZH2_k127_9706785_55
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
K12573
-
-
0.000000000000000000000000001052
115.0
DEZH2_k127_9772436_0
PFAM Radical SAM domain protein
K06871,K06941
-
2.1.1.192
0.00000000000001773
77.0
DEZH2_k127_9772436_1
Elongator protein 3, MiaB family, Radical SAM
-
-
-
0.00002294
51.0
DEZH2_k127_9772436_2
B12 binding domain
-
-
-
0.0005888
47.0
DEZH2_k127_9925754_0
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K11717
-
2.8.1.7,4.4.1.16
0.000000000000000000000000000000001345
134.0
DEZH2_k127_9925754_12
restriction
K01154
-
3.1.21.3
0.00000000000000000000000000000009138
127.0
DEZH2_k127_9925754_13
KR domain
-
-
-
0.000000000000000000000000000002064
123.0
DEZH2_k127_9925754_14
N-6 DNA Methylase
K03427
-
2.1.1.72
0.000000000000000000000000002168
112.0
DEZH2_k127_9925754_15
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0000000000000000001321
94.0
DEZH2_k127_9925754_24
Alpha/beta hydrolase family
K06889
-
-
0.0000000000000000003721
87.0
DEZH2_k127_9925754_25
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family
K11717
-
2.8.1.7,4.4.1.16
0.000000000000000001403
89.0
DEZH2_k127_9925754_26
-
-
-
-
0.00000000000000005165
84.0
DEZH2_k127_9925754_27
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.00000005827
63.0
DEZH2_k127_9925754_42
COG NOG38524 non supervised orthologous group
-
-
-
0.00000007661
55.0
DEZH2_k127_9925754_43
-
-
-
-
0.0000001179
53.0
DEZH2_k127_9925754_44
Dienelactone hydrolase family
K06889
-
-
0.0000007452
50.0
DEZH2_k127_9925754_45
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K07568
-
2.4.99.17
0.000004433
51.0
DEZH2_k127_9925754_46
restriction
K01154
-
3.1.21.3
0.00001681
48.0
DEZH2_k127_9925754_47
N-6 DNA methylase
K03427
-
2.1.1.72
0.00005127
46.0
DEZH2_k127_9925754_48
Uncharacterized protein conserved in bacteria (DUF2331)
-
-
-
0.00005689
52.0
DEZH2_k127_9925754_49
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
-
-
-
0.00007813
49.0
DEZH2_k127_9925754_5
Belongs to the short-chain dehydrogenases reductases (SDR) family
