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Overview

ID MAG00761
Name DTH2_bin.19
Sample SMP0023
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Nitrosomonadaceae
Genus Nitrosomonas
Species Nitrosomonas sp005779435
Assembly information
Completeness (%) 66.29
Contamination (%) 1.47
GC content (%) 52.0
N50 (bp) 3,466
Genome size (bp) 1,310,669

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1505

Gene name Description KEGG GOs EC E-value Score Sequence
DTH2_k127_10009610_0 PFAM Metal-dependent phosphohydrolase, HD K01768 - 4.6.1.1 9.772e-211 657.0
DTH2_k127_10009610_1 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 425.0
DTH2_k127_10009610_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 313.0
DTH2_k127_10009610_3 Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000000000000000000000000000000000000000000000002164 232.0
DTH2_k127_10024827_0 Response regulator receiver K02487,K03407,K06596 - 2.7.13.3 2.62e-211 663.0
DTH2_k127_10024827_1 Bacterial regulatory helix-turn-helix protein, lysR family K13634 - - 0.000000000000000000000000004273 111.0
DTH2_k127_10034838_0 Nucleoside H+ symporter K05820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 289.0
DTH2_k127_10034838_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000001549 201.0
DTH2_k127_10034838_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000004781 154.0
DTH2_k127_10044091_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1116.0
DTH2_k127_10044091_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 458.0
DTH2_k127_10044091_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000006688 145.0
DTH2_k127_10044091_3 Glutaredoxin-like domain (DUF836) K00384 - 1.8.1.9 0.000000000000000000000000008733 111.0
DTH2_k127_1023755_0 D-isomer specific 2-hydroxyacid dehydrogenase K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 386.0
DTH2_k127_1023755_1 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000002607 138.0
DTH2_k127_1023755_2 - - - - 0.00000000000000000000000000005507 125.0
DTH2_k127_1037096_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 3.821e-285 880.0
DTH2_k127_1046683_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 3.926e-277 866.0
DTH2_k127_1046683_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 1.194e-243 760.0
DTH2_k127_1046683_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 3.2e-224 703.0
DTH2_k127_1046683_3 Soluble lytic murein transglycosylase L domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005894 276.0
DTH2_k127_1046683_4 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001675 249.0
DTH2_k127_1046683_5 - - - - 0.0000000000000000000000000000000000000000000000000007844 186.0
DTH2_k127_1046683_6 7 transmembrane helices usually fused to an inactive transglutaminase - - - 0.0000000000000000000000000000000000000000000007249 166.0
DTH2_k127_1046683_7 YoeB-like toxin of bacterial type II toxin-antitoxin system - - - 0.00000000000000000000000000000000000002953 144.0
DTH2_k127_1046683_8 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000000000000000002519 133.0
DTH2_k127_1052378_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 519.0
DTH2_k127_1052378_1 May be involved in recombination K03554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 475.0
DTH2_k127_1052378_2 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000000000000000000000000000000000000005565 199.0
DTH2_k127_1056737_0 Histidine kinase K20974 - 2.7.13.3 0.0 1238.0
DTH2_k127_1056737_1 MltA specific insert domain K08304 - - 0.0000000000000000000000000000000000001199 141.0
DTH2_k127_1056737_2 - - - - 0.00000000000000000000000001252 115.0
DTH2_k127_1072314_0 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1330.0
DTH2_k127_1072314_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000004994 79.0
DTH2_k127_1135929_0 Methionine synthase K00548 - 2.1.1.13 0.0 2317.0
DTH2_k127_1135929_1 - - - - 0.00000000000000000000000000000000000000000000000000003693 188.0
DTH2_k127_117166_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.515e-250 777.0
DTH2_k127_117166_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 419.0
DTH2_k127_117166_2 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 331.0
DTH2_k127_1172684_0 alcohol dehydrogenase K00001 - 1.1.1.1 2.931e-209 655.0
DTH2_k127_1172684_1 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 429.0
DTH2_k127_1172684_2 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 391.0
DTH2_k127_1172684_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003231 224.0
DTH2_k127_1172684_4 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000000001378 161.0
DTH2_k127_1172684_5 - - - - 0.00000000000000000000000000000001046 130.0
DTH2_k127_1215797_0 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 386.0
DTH2_k127_1215797_1 Dynamin family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003411 235.0
DTH2_k127_1215797_2 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000000000000000000000000000008643 200.0
DTH2_k127_1217815_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 1.76e-255 793.0
DTH2_k127_1217815_1 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000621 106.0
DTH2_k127_1220521_0 Uncharacterized protein family (UPF0051) K09014 - - 7.284e-306 938.0
DTH2_k127_1220521_1 Uncharacterized protein family (UPF0051) K09015 - - 1.449e-215 676.0
DTH2_k127_1220521_2 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 471.0
DTH2_k127_1220521_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000003834 225.0
DTH2_k127_1285839_0 MMPL family K07003 - - 1.363e-263 821.0
DTH2_k127_1285839_1 glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 539.0
DTH2_k127_1285839_2 MlaC protein K07323 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004236 281.0
DTH2_k127_1299336_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 2.304e-205 651.0
DTH2_k127_1299336_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 355.0
DTH2_k127_1299336_2 to AA sequence GI 30249492 - - - 0.000000000000006082 74.0
DTH2_k127_1318593_0 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 536.0
DTH2_k127_1318593_1 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000003132 235.0
DTH2_k127_135219_0 Dicarboxylate transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 476.0
DTH2_k127_135219_1 PFAM Uncharacterised conserved protein UCP025560 K09978 - - 0.000000000000000000000000000000000000005102 148.0
DTH2_k127_135219_2 YnbE-like lipoprotein - - - 0.0000000000000000000001267 100.0
DTH2_k127_1353771_0 PFAM Alanine dehydrogenase PNT K00324 - 1.6.1.2 1.516e-206 646.0
DTH2_k127_1353771_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 594.0
DTH2_k127_1353771_2 4TM region of pyridine nucleotide transhydrogenase, mitoch K00322,K00324 - 1.6.1.1,1.6.1.2 0.000000000000000000000000000000000000000000000000000000254 196.0
DTH2_k127_1360692_0 Belongs to the ParA family K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 507.0
DTH2_k127_1360692_1 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization K03610 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 397.0
DTH2_k127_1360692_2 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002328 249.0
DTH2_k127_1360692_3 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell K03608 - - 0.000000000000000000000000000000000000000178 151.0
DTH2_k127_1360692_4 Domain of unknown function (DUF3362) - - - 0.00008702 45.0
DTH2_k127_1380560_0 cytochrome complex assembly K02200,K04018,K19225,K21007 - 3.4.21.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 371.0
DTH2_k127_1380560_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008459 237.0
DTH2_k127_1380560_3 Domain of unknown function (DUF3362) - - - 0.00006547 45.0
DTH2_k127_1388168_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004577 229.0
DTH2_k127_1388168_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000002631 220.0
DTH2_k127_1388168_2 - - - - 0.0000000000000005244 81.0
DTH2_k127_140054_0 AcrB/AcrD/AcrF family K07787 - - 0.0 1431.0
DTH2_k127_140054_1 Copper binding periplasmic protein CusF K07798,K15727 - - 6.424e-238 745.0
DTH2_k127_140054_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 557.0
DTH2_k127_1423636_0 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 2.488e-239 746.0
DTH2_k127_1423636_1 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 432.0
DTH2_k127_1423636_2 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0012505,GO:0016192,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0030141,GO:0030554,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004838 264.0
DTH2_k127_1423636_3 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001397 261.0
DTH2_k127_1425113_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 5.819e-203 634.0
DTH2_k127_1425113_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 1.218e-197 617.0
DTH2_k127_1425113_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 490.0
DTH2_k127_1425113_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 440.0
DTH2_k127_1425113_4 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000004596 201.0
DTH2_k127_1433634_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 2.166e-208 650.0
DTH2_k127_1433634_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 8.285e-203 633.0
DTH2_k127_1433634_2 Prephenate dehydratase K01713,K14170 - 4.2.1.51,4.2.1.91,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 577.0
DTH2_k127_1433634_3 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 544.0
DTH2_k127_1433634_4 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 408.0
DTH2_k127_1436251_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 8.63e-263 813.0
DTH2_k127_1436251_1 SMART Diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008807 239.0
DTH2_k127_1436251_2 Domain of unknown function (DUF3362) - - - 0.000000002441 58.0
DTH2_k127_1482186_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1287.0
DTH2_k127_1482186_1 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000062 100.0
DTH2_k127_1482186_2 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000005379 65.0
DTH2_k127_1482186_3 Domain of unknown function (DUF3362) - - - 0.00007283 48.0
DTH2_k127_1500789_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 3.52e-248 767.0
DTH2_k127_1500789_1 Cell wall hydrolase autolysin K01448 - 3.5.1.28 7.15e-242 752.0
DTH2_k127_1500789_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 6.3e-238 737.0
DTH2_k127_1500789_3 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 583.0
DTH2_k127_1500789_4 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000000000000000000000000000000003266 182.0
DTH2_k127_1500789_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000001753 164.0
DTH2_k127_1520716_0 PFAM Peptidase S11, D-alanyl-D-alanine carboxypeptidase A K01286,K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 472.0
DTH2_k127_1520716_1 PFAM Sulfotransferase K01014 - 2.8.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 456.0
DTH2_k127_1537142_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 9.873e-222 688.0
DTH2_k127_1537142_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 451.0
DTH2_k127_1538730_0 flagellar motor switch protein FliM K02416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 394.0
DTH2_k127_1538730_1 Flagellar hook-length control K02414 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002138 282.0
DTH2_k127_1538730_2 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004371 243.0
DTH2_k127_1560104_0 Pyridine nucleotide-disulphide oxidoreductase K05297,K12265 - 1.18.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 597.0
DTH2_k127_1560104_1 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 287.0
DTH2_k127_1560104_2 Rubredoxin - - - 0.000000000000000000000000003394 110.0
DTH2_k127_1575385_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008206 546.0
DTH2_k127_1575385_1 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007061 448.0
DTH2_k127_1575385_2 HAD-superfamily hydrolase, subfamily IA, variant 1 K22292 - 3.1.3.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008165 382.0
DTH2_k127_1651348_0 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 583.0
DTH2_k127_1651348_1 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 392.0
DTH2_k127_1651348_2 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 389.0
DTH2_k127_1651348_3 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000000000000000000634 225.0
DTH2_k127_1663798_0 Patatin-like phospholipase K07001 - - 8.246e-220 685.0
DTH2_k127_1663798_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 372.0
DTH2_k127_1663798_2 PFAM Integral membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 373.0
DTH2_k127_1663798_3 - - - - 0.000000000000000000002179 95.0
DTH2_k127_1671238_0 Belongs to the helicase family. UvrD subfamily K03582 - 3.1.11.5 4.309e-237 745.0
DTH2_k127_1671238_1 PD-(D/E)XK nuclease superfamily K01144 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 423.0
DTH2_k127_167774_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 424.0
DTH2_k127_167774_1 Nucleoside-binding outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000006666 240.0
DTH2_k127_1709264_0 OsmC-like protein K06889,K07397 - - 2.618e-206 648.0
DTH2_k127_1709264_1 PFAM Class II aldolase adducin K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009494 488.0
DTH2_k127_1709264_2 ISXO2-like transposase domain K07488 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008795 430.0
DTH2_k127_1709264_3 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 376.0
DTH2_k127_1709264_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009227 289.0
DTH2_k127_1709264_5 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002632 283.0
DTH2_k127_1709264_6 PFAM RNA-binding S4 K04762 - - 0.00000000000000000000000000000000000000000000000000000006612 198.0
DTH2_k127_1709264_7 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000003502 127.0
DTH2_k127_1713818_0 PFAM TonB-dependent receptor, beta-barrel - - - 1.315e-248 772.0
DTH2_k127_1713818_1 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 469.0
DTH2_k127_1713818_2 Diguanylate cyclase phosphodiesterase with PAS PAC K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000002159 151.0
DTH2_k127_1722364_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 8.436e-207 644.0
DTH2_k127_1722364_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 539.0
DTH2_k127_1722364_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 291.0
DTH2_k127_1722767_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1313.0
DTH2_k127_1722767_1 zinc metalloprotease K11749 - - 6.156e-240 747.0
DTH2_k127_1722767_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 4.627e-214 670.0
DTH2_k127_1722767_3 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 413.0
DTH2_k127_1722767_4 Belongs to the skp family K06142 - - 0.000000000000000000000000000000000000000000000003448 177.0
DTH2_k127_1786751_0 WD40-like Beta Propeller Repeat - - - 3.722e-213 664.0
DTH2_k127_1786751_1 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 338.0
DTH2_k127_1786751_2 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 332.0
DTH2_k127_1786751_3 TPM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005008 248.0
DTH2_k127_1786751_4 hydrogenase maturation protease - - - 0.000000000000000000000000000000000000000000000000000000000000002309 220.0
DTH2_k127_1786751_6 pdz dhr glgf - - - 0.0001091 49.0
DTH2_k127_183830_0 Glutathione S-transferase, N-terminal domain K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 392.0
DTH2_k127_183830_1 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 334.0
DTH2_k127_183830_2 stringent starvation protein B K03600 - - 0.00000000000000000000000000000000000000002074 156.0
DTH2_k127_1843407_0 Plays a role in the flagellum-specific transport system K02419 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 436.0
DTH2_k127_1843407_1 Role in flagellar biosynthesis K02421 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 429.0
DTH2_k127_1843407_2 Flagellar motor switch K02417,K03225 - - 0.000000000000000000000000000000000000000000000000000000000000000000003465 238.0
DTH2_k127_1843407_3 flagellar motor switch protein FliM K02416 - - 0.0000000000000000000000000000000000000000000000001318 177.0
DTH2_k127_1843407_4 Role in flagellar biosynthesis K02420 - - 0.000000000000000000000000000000000000000000237 159.0
DTH2_k127_1843407_5 flagellar biosynthesis protein K02418 - - 0.0000000000000000000000000000000001912 136.0
DTH2_k127_1864109_0 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 472.0
DTH2_k127_1864109_1 Haem-degrading - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 279.0
DTH2_k127_1864109_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000001813 204.0
DTH2_k127_1884874_0 Transporter associated domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 471.0
DTH2_k127_1884874_1 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 315.0
DTH2_k127_1884874_2 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000000000000000000000000001184 226.0
DTH2_k127_1904109_0 PFAM Metal-dependent phosphohydrolase, HD K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 553.0
DTH2_k127_1904109_1 endonuclease exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 461.0
DTH2_k127_1904109_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000005089 155.0
DTH2_k127_1940523_0 Cytochrome P450 - - - 5.537e-240 745.0
DTH2_k127_1943399_0 ribonuclease II K01147 - 3.1.13.1 4.833e-214 670.0
DTH2_k127_1943399_1 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 445.0
DTH2_k127_1943399_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 426.0
DTH2_k127_1943399_3 NlpC/P60 family K13695,K19303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003035 249.0
DTH2_k127_1943399_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000002543 235.0
DTH2_k127_1951053_0 PFAM Peptidase M16 K07263 - - 3.86e-244 762.0
DTH2_k127_1951053_1 EF hand - - - 0.00000000000000000000000006387 112.0
DTH2_k127_195552_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 1.906e-252 790.0
DTH2_k127_195552_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.57e-204 642.0
DTH2_k127_195552_2 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 581.0
DTH2_k127_2003547_0 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 5.12e-244 760.0
DTH2_k127_2003547_1 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 344.0
DTH2_k127_2003547_2 - - - - 0.000000000000000000000000000000000001633 142.0
DTH2_k127_2003547_3 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.000000000000000005836 88.0
DTH2_k127_2017867_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0 1056.0
DTH2_k127_2017867_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 3.404e-216 679.0
DTH2_k127_2042396_0 FAD linked oxidase K00104,K11472 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 492.0
DTH2_k127_2042396_1 FAD linked oxidases, C-terminal domain K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 310.0
DTH2_k127_2042396_2 4Fe-4S double cluster binding domain K11473 - - 0.00000000000008185 71.0
DTH2_k127_2057791_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1662.0
DTH2_k127_2057791_1 PFAM Peptidase M16 K07263 - - 2.778e-222 695.0
DTH2_k127_2057791_2 PFAM Metal-dependent hydrolase HDOD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 389.0
DTH2_k127_2057791_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 295.0
DTH2_k127_2057791_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000001503 249.0
DTH2_k127_2057791_5 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000002917 222.0
DTH2_k127_2057791_6 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000003382 161.0
DTH2_k127_211320_0 AMP-dependent synthetase K01897 - 6.2.1.3 1.093e-280 868.0
DTH2_k127_2113639_0 PFAM TonB-dependent receptor, beta-barrel - - - 0.0 1005.0
DTH2_k127_2113639_1 PFAM MotA TolQ ExbB proton channel K03561 - - 2.771e-237 741.0
DTH2_k127_2113639_2 TPR repeat - - - 4.43e-210 657.0
DTH2_k127_2113639_3 Protein of unknown function (DUF3450) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 417.0
DTH2_k127_2113639_4 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 388.0
DTH2_k127_2113639_5 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 342.0
DTH2_k127_2113639_6 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.000000000000000000000000000000000000000000000000000000000000000000006466 237.0
DTH2_k127_2113639_7 Phosphate-starvation-inducible E - - - 0.000000000000000000000000000000000000000000000000000000000000000113 224.0
DTH2_k127_2113639_8 TIGRFAM Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.0000000000000002274 79.0
DTH2_k127_2238990_0 Cysteine-rich domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 521.0
DTH2_k127_2238990_1 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000000001623 226.0
DTH2_k127_2243882_0 Zinc-binding dehydrogenase K00001,K00344 - 1.1.1.1,1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 502.0
DTH2_k127_2243882_1 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 473.0
DTH2_k127_2243882_2 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 348.0
DTH2_k127_2243882_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008709 332.0
DTH2_k127_2247996_0 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 452.0
DTH2_k127_2247996_1 invasion associated locus B - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001774 279.0
DTH2_k127_2247996_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000000000000000002203 222.0
DTH2_k127_2247996_3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000000002067 199.0
DTH2_k127_2247996_4 Belongs to the ArsC family K00537 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000002132 186.0
DTH2_k127_2247996_5 Domain of unknown function (DUF2024) - - - 0.00000000000000000000000000000000000000000000001102 171.0
DTH2_k127_2247996_6 O-methyltransferase - - - 0.00000000001457 64.0
DTH2_k127_2308152_0 PFAM Copper resistance D K07245 - - 1.253e-285 889.0
DTH2_k127_2308152_1 Formate acetyltransferase K00656 - 2.3.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 467.0
DTH2_k127_231945_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K18005 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 451.0
DTH2_k127_231945_1 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 332.0
DTH2_k127_2321288_0 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 495.0
DTH2_k127_2321288_1 dna methylase K00571,K07316 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 285.0
DTH2_k127_2321288_2 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 0.0000000000000000000000000000000000000000000000000000000000003062 213.0
DTH2_k127_2346766_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1183.0
DTH2_k127_2346766_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000003618 264.0
DTH2_k127_2346766_2 AraC-like ligand binding domain - - - 0.000000000000000000002412 96.0
DTH2_k127_2377702_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1299.0
DTH2_k127_2377702_1 Sigma-54 interaction domain - - - 2.441e-251 777.0
DTH2_k127_2417943_0 Belongs to the sulfur carrier protein TusA family - - - 2.459e-199 627.0
DTH2_k127_2417943_1 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 491.0
DTH2_k127_2417943_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 477.0
DTH2_k127_2417943_3 - - - - 0.000000000000000000000000000000000001588 138.0
DTH2_k127_2438138_0 Scaffold protein Nfu/NifU N terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 354.0
DTH2_k127_2438138_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02657 - - 0.00000000000000000000000009622 114.0
DTH2_k127_2438138_2 Domain of unknown function (DUF3362) - - - 0.000000006356 57.0
DTH2_k127_2455723_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 493.0
DTH2_k127_2455723_1 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000003232 199.0
DTH2_k127_2455723_2 transporter component K07112 - - 0.00000000000000000000000000000000000000000000000000000005089 198.0
DTH2_k127_2455723_3 PFAM Heat shock protein DnaJ, N-terminal - - - 0.00000000000000000000000000000000000000000000001752 173.0
DTH2_k127_2505850_0 The M ring may be actively involved in energy transduction K02409 - - 1.891e-267 831.0
DTH2_k127_2505850_1 ATP synthase alpha/beta family, nucleotide-binding domain K02412 - 3.6.3.14 6.373e-225 701.0
DTH2_k127_2505850_2 Flagellar motor switch K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 430.0
DTH2_k127_2505850_3 flagellar assembly protein FliH K02411 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 284.0
DTH2_k127_2525773_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 1.004e-246 764.0
DTH2_k127_2525773_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 8.782e-198 619.0
DTH2_k127_2525773_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 8.092e-194 607.0
DTH2_k127_2525773_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 505.0
DTH2_k127_2525773_4 malonyl CoA-acyl carrier protein transacylase K00645,K13935,K15355 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 495.0
DTH2_k127_2525773_5 Short-chain dehydrogenase reductase SDR K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 428.0
DTH2_k127_2525773_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000000001405 142.0
DTH2_k127_2525773_7 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000000000000005405 130.0
DTH2_k127_2525773_8 PFAM Glycosyl transferase, family 2 K00721,K00786 - 2.4.1.83 0.00000000002023 65.0
DTH2_k127_2575015_0 PFAM Aminotransferase, class V K04487 - 2.8.1.7 4.636e-210 657.0
DTH2_k127_2575015_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004159 269.0
DTH2_k127_2575015_2 PFAM Nucleotidyl transferase - - - 0.0000000000152 66.0
DTH2_k127_2579203_0 RNA polymerase recycling family C-terminal K03580 - - 7.258e-271 835.0
DTH2_k127_258309_0 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 583.0
DTH2_k127_258309_1 pyruvate-flavodoxin oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004164 278.0
DTH2_k127_258574_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0 1075.0
DTH2_k127_258574_1 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000000000000000000000000587 224.0
DTH2_k127_2609302_0 AI-2E family transporter - - - 6.513e-194 608.0
DTH2_k127_2609302_1 TIGRFAM HAD-superfamily hydrolase, subfamily IB (PSPase-like) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 425.0
DTH2_k127_2609302_2 Belongs to the DnaA family K10763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 318.0
DTH2_k127_2609302_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00819 - 2.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000358 223.0
DTH2_k127_2609302_5 - - - - 0.0000004498 53.0
DTH2_k127_2684095_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.582e-245 767.0
DTH2_k127_268449_0 DinB superfamily - - - 0.0 1345.0
DTH2_k127_268449_1 PFAM aminotransferase, class I K00842,K14155 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 508.0
DTH2_k127_2803286_0 Signal transduction histidine kinase K07636 - 2.7.13.3 1.281e-221 692.0
DTH2_k127_2803286_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 384.0
DTH2_k127_2803286_2 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000000000000000000000000000006235 221.0
DTH2_k127_2803286_3 - - - - 0.0000000000000000000000000000000000000000000000000001371 187.0
DTH2_k127_2878518_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 2.246e-199 623.0
DTH2_k127_2878518_1 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 338.0
DTH2_k127_2878518_2 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000000000000000001293 258.0
DTH2_k127_2878518_3 transposase activity K07493 - - 0.00000000004777 63.0
DTH2_k127_2893752_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1162.0
DTH2_k127_2893752_1 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 516.0
DTH2_k127_2893752_2 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 472.0
DTH2_k127_2893752_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 460.0
DTH2_k127_2893752_4 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 447.0
DTH2_k127_2893752_5 - - - - 0.000000000000000000000000000000000000000000004906 171.0
DTH2_k127_2893752_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000000145 105.0
DTH2_k127_2893752_7 DNA polymerase III, epsilon subunit K02342 - 2.7.7.7 0.000001783 52.0
DTH2_k127_2918055_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 7.16e-210 653.0
DTH2_k127_2918055_1 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004988 501.0
DTH2_k127_2918055_2 POTRA domain, FtsQ-type - - - 0.000000000000000000000000000000000000000002486 165.0
DTH2_k127_2918055_3 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000003977 149.0
DTH2_k127_2939337_0 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - 1.241e-255 790.0
DTH2_k127_2939337_1 O-Antigen ligase K02847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 517.0
DTH2_k127_2939337_2 PFAM Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 496.0
DTH2_k127_2939337_3 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 480.0
DTH2_k127_2939337_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 464.0
DTH2_k127_2939337_5 Cytidylyltransferase K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 394.0
DTH2_k127_2939337_6 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000157 265.0
DTH2_k127_2954438_0 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001304 272.0
DTH2_k127_2954438_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000001041 209.0
DTH2_k127_2954438_2 Protein of unknown function (DUF3293) - - - 0.00000000000000000000000000000000000000000436 160.0
DTH2_k127_2954438_3 Tim44 - - - 0.000000000000000000005701 93.0
DTH2_k127_2954438_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00001801 51.0
DTH2_k127_3007541_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.474e-251 780.0
DTH2_k127_3007541_2 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 403.0
DTH2_k127_3007541_3 Nudix hydrolase K08310 - 3.6.1.67 0.0000000000000000000000000000000000000000000000000000000000000000000000006121 247.0
DTH2_k127_301972_0 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 4.64e-239 743.0
DTH2_k127_301972_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 595.0
DTH2_k127_301972_2 lipid kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 530.0
DTH2_k127_301972_3 lipid kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 478.0
DTH2_k127_301972_4 PFAM Smr protein MutS2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001618 266.0
DTH2_k127_301972_5 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000000000000000000000000000000000000000000000000001259 217.0
DTH2_k127_301972_6 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000001835 49.0
DTH2_k127_3026376_0 Nickel-dependent hydrogenase K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 2.345e-294 908.0
DTH2_k127_3026376_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K18005 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 490.0
DTH2_k127_3026376_2 4Fe-4S single cluster domain K18006 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 417.0
DTH2_k127_3026376_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 394.0
DTH2_k127_3026376_4 NADH ubiquinone oxidoreductase, 20 Kd subunit K18007 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002182 281.0
DTH2_k127_3037760_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001295 270.0
DTH2_k127_3065472_0 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 340.0
DTH2_k127_3065472_1 SMART Diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008135 238.0
DTH2_k127_3065472_2 Dodecin K09165 - - 0.0000000000000000000000000000004559 124.0
DTH2_k127_3065472_3 FtsX-like permease family K02004 - - 0.000000000000000000005991 92.0
DTH2_k127_3103220_0 PFAM Major facilitator superfamily K08218 - - 1.837e-255 792.0
DTH2_k127_3103220_1 AFG1-like ATPase K06916 - - 1.009e-195 616.0
DTH2_k127_3103220_2 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 484.0
DTH2_k127_3103220_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 365.0
DTH2_k127_3107823_0 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 503.0
DTH2_k127_3107823_1 PFAM Glycoside hydrolase, family 19, catalytic K03791 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001483 246.0
DTH2_k127_3107823_2 Protein of unknown function (DUF1353) - - - 0.0000000000000000000213 94.0
DTH2_k127_3107823_4 HNH nucleases - - - 0.0002575 49.0
DTH2_k127_3111103_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 538.0
DTH2_k127_3111103_1 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 479.0
DTH2_k127_3111103_2 UBA THIF-type NAD FAD binding K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 375.0
DTH2_k127_3111103_3 Bacterial regulatory proteins, tetR family K05501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 295.0
DTH2_k127_3122128_0 fatty acid desaturase K00507 - 1.14.19.1 2.161e-239 741.0
DTH2_k127_3122128_1 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 296.0
DTH2_k127_3122128_2 Phosphoglycerate mutase family K08296 - - 0.000000000000000000000000000000000000000236 152.0
DTH2_k127_3126343_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 1.5e-323 990.0
DTH2_k127_3126343_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 379.0
DTH2_k127_3127686_0 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 6.272e-204 638.0
DTH2_k127_3127686_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 595.0
DTH2_k127_3127686_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 547.0
DTH2_k127_3127686_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 502.0
DTH2_k127_3127686_4 Glycine-zipper domain - - - 0.00000000000000002212 81.0
DTH2_k127_3136376_0 Putative neutral zinc metallopeptidase K06973 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 393.0
DTH2_k127_3136376_1 Type II secretion system K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 364.0
DTH2_k127_3136376_2 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006522 270.0
DTH2_k127_3136376_3 - - - - 0.00000000000000000000000000000000000000006768 158.0
DTH2_k127_316753_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 475.0
DTH2_k127_316753_1 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001651 261.0
DTH2_k127_31688_0 adenylyltransferase, small subunit K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 572.0
DTH2_k127_31688_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 322.0
DTH2_k127_3201996_0 7 transmembrane helices usually fused to an inactive transglutaminase - - - 2.623e-221 691.0
DTH2_k127_3201996_1 Signal transduction histidine kinase, phosphotransfer (Hpt) - - - 4.858e-211 667.0
DTH2_k127_3201996_2 Sugar-transfer associated ATP-grasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 485.0
DTH2_k127_3201996_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0003244 48.0
DTH2_k127_3214954_0 acyl-CoA dehydrogenase K06445 - - 0.0 1145.0
DTH2_k127_3228935_0 glycyl-tRNA aminoacylation K01879 - 6.1.1.14 0.0 1125.0
DTH2_k127_3228935_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 3.147e-208 651.0
DTH2_k127_3228935_2 Glycyl-tRNA synthetase K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 590.0
DTH2_k127_3228935_3 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 452.0
DTH2_k127_3228935_4 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 341.0
DTH2_k127_3228935_5 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 310.0
DTH2_k127_3228935_6 Uncharacterised protein conserved in bacteria (DUF2326) - - - 0.0000001984 57.0
DTH2_k127_3243077_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 520.0
DTH2_k127_3243077_1 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000000000000000000000000000000000006379 139.0
DTH2_k127_3243077_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.00000000000000000000000000000000001532 135.0
DTH2_k127_3243077_3 Belongs to the 'phage' integrase family - - - 0.00001963 47.0
DTH2_k127_330178_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.808e-248 771.0
DTH2_k127_330178_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002774 228.0
DTH2_k127_330178_2 PFAM EAL domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000005558 232.0
DTH2_k127_3308975_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 6.063e-259 801.0
DTH2_k127_3308975_1 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 311.0
DTH2_k127_3327697_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 573.0
DTH2_k127_3327697_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 488.0
DTH2_k127_3327697_2 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 465.0
DTH2_k127_3327697_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 380.0
DTH2_k127_3327697_4 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 349.0
DTH2_k127_3327697_5 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000001086 139.0
DTH2_k127_3327697_6 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000007974 59.0
DTH2_k127_3343458_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1227.0
DTH2_k127_3343458_1 PFAM Transposase, IS66 K07484 - - 0.000000004265 57.0
DTH2_k127_3349823_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 3.696e-197 617.0
DTH2_k127_3349823_1 PFAM Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007604 249.0
DTH2_k127_3349823_2 addiction module antidote protein HigA K21498 - - 0.00000000000000000000000000000000000000000003231 165.0
DTH2_k127_3349823_3 Belongs to the N-Me-Phe pilin family K02650,K02682 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000000000000000000000000000000000000000001046 166.0
DTH2_k127_3349823_4 Protein of unknown function (DUF2442) - - - 0.00000000000000000000000000000002777 126.0
DTH2_k127_3349823_5 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000001612 111.0
DTH2_k127_3349823_6 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.0004226 45.0
DTH2_k127_3361582_0 Peptidase family M1 domain - - - 0.0 1020.0
DTH2_k127_3361582_1 pdz dhr glgf - - - 0.0000000001693 61.0
DTH2_k127_3364978_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1064.0
DTH2_k127_3364978_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000003623 203.0
DTH2_k127_3368349_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 5.574e-208 649.0
DTH2_k127_3368349_1 DNA polymerase III (Chi subunit) K02339 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000008401 203.0
DTH2_k127_3368349_2 Bacterial regulatory helix-turn-helix protein, lysR family K03576 - - 0.000000000000000000000006397 101.0
DTH2_k127_3368349_3 - - - - 0.0000000000000001076 84.0
DTH2_k127_3393604_0 Belongs to the ClpA ClpB family K03694 - - 0.0 1028.0
DTH2_k127_3393604_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 337.0
DTH2_k127_3393604_2 Domain of unknown function (DUF3362) - - - 0.0000000009374 59.0
DTH2_k127_3445353_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.0 1067.0
DTH2_k127_3445353_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 341.0
DTH2_k127_3445353_2 TIGRFAM Acetolactate synthase, small subunit K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006644 297.0
DTH2_k127_3458315_0 Belongs to the GSP D family K02666 - - 2.619e-291 900.0
DTH2_k127_3479208_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 1.45e-299 921.0
DTH2_k127_3479208_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 2.063e-272 842.0
DTH2_k127_3479208_2 chain 5 L K00341 - 1.6.5.3 0.000000000000000000137 88.0
DTH2_k127_3482727_0 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 455.0
DTH2_k127_3482727_1 PFAM Fimbrial assembly K02663 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007062 282.0
DTH2_k127_3482727_2 Pilus assembly protein, PilO K02664 - - 0.000000000009721 65.0
DTH2_k127_3486528_0 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 427.0
DTH2_k127_3486528_1 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001609 263.0
DTH2_k127_3529867_0 COG2873 O-acetylhomoserine sulfhydrylase K01740 - 2.5.1.49 2.006e-216 677.0
DTH2_k127_3529867_1 Ribosomal RNA adenine dimethylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 533.0
DTH2_k127_3529867_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 407.0
DTH2_k127_3529867_3 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000000000000000000000000000002341 141.0
DTH2_k127_3529867_4 addiction module component, TIGR02574 family - - - 0.000000000000000000001312 96.0
DTH2_k127_3565272_0 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 8.267e-240 744.0
DTH2_k127_3565272_1 Putative diguanylate phosphodiesterase - - - 4.443e-207 654.0
DTH2_k127_3565272_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007244 473.0
DTH2_k127_3565272_3 DNA polymerase III K01141 - 3.1.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 448.0
DTH2_k127_3565272_4 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004256 244.0
DTH2_k127_3570281_0 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 573.0
DTH2_k127_3570281_1 Tex-like protein N-terminal domain K06959 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007795 351.0
DTH2_k127_3570281_2 Tex-like protein N-terminal domain K06959 - - 0.00000000000000000000000000000000000000003236 153.0
DTH2_k127_3570281_3 RF-1 domain K15034 - - 0.000000000000000000001757 96.0
DTH2_k127_358550_0 Glutaminyl-tRNA synthetase K01886 - 6.1.1.18 0.0 994.0
DTH2_k127_358550_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 589.0
DTH2_k127_358550_2 Short-chain dehydrogenase reductase SDR K00059,K03793 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004366 424.0
DTH2_k127_358550_3 PFAM Aminotransferase, class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000023 271.0
DTH2_k127_3591549_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0 1045.0
DTH2_k127_3591549_1 L,D-transpeptidase catalytic domain K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009688 560.0
DTH2_k127_3591549_2 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000000000000000003893 163.0
DTH2_k127_3591549_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000000005276 114.0
DTH2_k127_3591549_4 ISXO2-like transposase domain K07488 - - 0.00000000000000000002656 90.0
DTH2_k127_3591549_5 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000000001748 79.0
DTH2_k127_3610162_0 Carbamoyl-phosphate synthetase large chain domain protein K01941 - 6.3.4.6 0.0 1097.0
DTH2_k127_3610162_1 - - - - 0.00000000000000000000000000032 115.0
DTH2_k127_3623855_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 4.014e-266 824.0
DTH2_k127_3623855_1 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 604.0
DTH2_k127_3623855_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 410.0
DTH2_k127_3623855_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000002743 228.0
DTH2_k127_3623855_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000001931 214.0
DTH2_k127_3623855_5 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000000000000000000000000004961 218.0
DTH2_k127_36566_0 ABC-type uncharacterized transport system - - - 6.297e-219 687.0
DTH2_k127_36566_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009484 421.0
DTH2_k127_36566_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 405.0
DTH2_k127_36566_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007945 321.0
DTH2_k127_36566_4 YGGT family K02221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 314.0
DTH2_k127_36566_5 Domain of unknown function (DUF4340) - - - 0.0000000000000000000000000000000000000000000000001041 182.0
DTH2_k127_36566_6 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000000000000000002042 134.0
DTH2_k127_3691084_0 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 555.0
DTH2_k127_3691084_1 ABC transporter K02021,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 448.0
DTH2_k127_3691084_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000029 123.0
DTH2_k127_3717763_0 PFAM peptidase - - - 5.62e-251 778.0
DTH2_k127_3717763_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 545.0
DTH2_k127_374196_0 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772,K03815 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 439.0
DTH2_k127_374196_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 287.0
DTH2_k127_374196_2 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001801 277.0
DTH2_k127_374196_3 - - - - 0.000000000000000000000000002319 113.0
DTH2_k127_374196_4 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0005502 47.0
DTH2_k127_3741990_0 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 611.0
DTH2_k127_3741990_1 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002292 270.0
DTH2_k127_3741990_2 PFAM Zinc iron permease K16267 - - 0.0000000000000000000000000000000000000000000000000000005518 194.0
DTH2_k127_3741990_3 Protein of unknown function (DUF4019) - - - 0.00000000000000000000000000000000000000000000001024 175.0
DTH2_k127_3761794_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 345.0
DTH2_k127_3761794_1 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000000000000000000000000000000000009555 209.0
DTH2_k127_3761794_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000005124 162.0
DTH2_k127_3761794_3 cheY-homologous receiver domain K02485 - - 0.00000000000000000000000000000000000005079 150.0
DTH2_k127_3761794_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000005088 125.0
DTH2_k127_3768695_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 1.635e-233 724.0
DTH2_k127_3768695_1 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006857 350.0
DTH2_k127_3787032_0 Hydrogenase formation hypA family K04654 - - 1.158e-212 664.0
DTH2_k127_3787032_1 AIR synthase related protein, N-terminal domain K04655 - - 0.000000000000000000000000000000000000000000000000000000000000009014 220.0
DTH2_k127_3787032_2 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000000000001068 124.0
DTH2_k127_3787032_3 L,D-transpeptidase catalytic domain - - - 0.0000004287 53.0
DTH2_k127_3812378_0 FAD linked oxidases, C-terminal domain K00102,K03777 - 1.1.2.4,1.1.5.12 2.002e-240 748.0
DTH2_k127_3812378_1 transport-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 303.0
DTH2_k127_3812378_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000001017 97.0
DTH2_k127_3815416_0 Cache domain - - - 3.305e-226 712.0
DTH2_k127_3815416_1 PFAM SH3, type 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001479 253.0
DTH2_k127_3815416_2 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000000000000000000000003997 228.0
DTH2_k127_3834728_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 1.421e-280 864.0
DTH2_k127_3834728_1 Soluble lytic murein transglycosylase L domain K08309 - - 3.497e-196 620.0
DTH2_k127_3834728_2 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000000000000004382 149.0
DTH2_k127_3843692_0 Histidine kinase - - - 1.225e-276 867.0
DTH2_k127_3843692_1 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 453.0
DTH2_k127_3843692_2 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 429.0
DTH2_k127_3843692_3 PFAM Signal transduction response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 371.0
DTH2_k127_3843692_4 - - - - 0.000000000000000000000000000000000000000000000005636 177.0
DTH2_k127_3843692_5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 0.00000005365 56.0
DTH2_k127_3852603_0 Involved in the TonB-independent uptake of proteins K03641 - - 1.543e-247 768.0
DTH2_k127_3852603_1 TolA C-terminal K03646 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 411.0
DTH2_k127_3852603_2 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 284.0
DTH2_k127_3852603_3 Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000006275 104.0
DTH2_k127_3852603_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000007962 67.0
DTH2_k127_389831_0 cytochrome C peroxidase - - - 2.438e-284 879.0
DTH2_k127_3906891_0 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 355.0
DTH2_k127_3906891_1 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 296.0
DTH2_k127_3906891_2 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789,K14742 - 2.3.1.128 0.0000000000000000000000000000001008 138.0
DTH2_k127_3906891_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000001621 87.0
DTH2_k127_3906891_4 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789,K14742 - 2.3.1.128 0.0000000000000001038 81.0
DTH2_k127_3919096_0 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 3.602e-203 636.0
DTH2_k127_3919096_1 Belongs to the flagella basal body rod proteins family K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 468.0
DTH2_k127_3919096_2 Rod binding protein K02395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 468.0
DTH2_k127_3919096_3 Belongs to the flagella basal body rod proteins family K02391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 419.0
DTH2_k127_3919096_4 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 372.0
DTH2_k127_3919096_5 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 282.0
DTH2_k127_3919096_6 Flagellar basal body rod protein K02390 - - 0.00000000000000000000000000000000000001452 145.0
DTH2_k127_3922974_0 HELICc2 K03722 - 3.6.4.12 2.152e-299 923.0
DTH2_k127_393385_0 Putative peptidoglycan binding domain K21470 - - 1.454e-220 698.0
DTH2_k127_393385_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000006666 169.0
DTH2_k127_3952134_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1049.0
DTH2_k127_3972925_0 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 385.0
DTH2_k127_3972925_1 N-6 DNA Methylase K03427 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 331.0
DTH2_k127_3972925_2 - - - - 0.000000000000000000000000000000159 132.0
DTH2_k127_3972925_3 Biopolymer transport protein ExbD/TolR - - - 0.00000000000007157 77.0
DTH2_k127_4006700_0 PFAM Permease YjgP YjgQ K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 574.0
DTH2_k127_4006700_1 PFAM Permease YjgP YjgQ K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 556.0
DTH2_k127_4006700_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 298.0
DTH2_k127_4006700_3 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001422 269.0
DTH2_k127_4006700_4 DNA topoisomerase, type IA, central K03169 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000006269 220.0
DTH2_k127_4006700_5 MobA-like NTP transferase domain - - - 0.0000000000000000000000000000000003012 132.0
DTH2_k127_4025706_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.0 1009.0
DTH2_k127_4025706_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 593.0
DTH2_k127_4025706_2 system, fructose subfamily IIA component K02821 - 2.7.1.194 0.000000000000000000000000000000000000000000000000000000000000005178 218.0
DTH2_k127_4025706_3 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000001691 144.0
DTH2_k127_4025706_4 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000007544 129.0
DTH2_k127_4026423_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor K02668 - 2.7.13.3 3.293e-237 744.0
DTH2_k127_4026423_1 Sigma-54 interaction domain K02667 - - 5.409e-203 635.0
DTH2_k127_4026423_2 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 556.0
DTH2_k127_4026423_3 - K06950 - - 0.00000000000000000000003824 100.0
DTH2_k127_4026423_4 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000003335 57.0
DTH2_k127_4032589_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 4.569e-264 816.0
DTH2_k127_4032589_1 Belongs to the thiolase family K00626 - 2.3.1.9 7.157e-203 636.0
DTH2_k127_4032589_2 - - - - 0.000000000000000000000000000000000000000000000000000715 186.0
DTH2_k127_4042085_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 2.937e-276 854.0
DTH2_k127_4042085_1 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 1.522e-238 740.0
DTH2_k127_4042085_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 539.0
DTH2_k127_4042210_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 8.33e-281 868.0
DTH2_k127_4042210_1 Response regulator receiver - - - 6.575e-227 714.0
DTH2_k127_4042210_2 Protein of unknown function (DUF692) K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 501.0
DTH2_k127_4042210_3 PFAM TonB-dependent receptor, plug K02014,K16089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 389.0
DTH2_k127_4042210_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 380.0
DTH2_k127_4042210_5 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 299.0
DTH2_k127_4042210_6 Putative DNA-binding domain K09929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005681 284.0
DTH2_k127_4042210_7 Domain of unknown function (DUF4154) - - - 0.0000000000000000000000000000000000000000000000000000000000003171 218.0
DTH2_k127_4042210_8 - - - - 0.000000000000000000000000000000000000005771 149.0
DTH2_k127_4069207_0 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 546.0
DTH2_k127_4069207_1 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002412 280.0
DTH2_k127_4080453_0 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 378.0
DTH2_k127_4080453_1 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) K03414 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 365.0
DTH2_k127_4080453_2 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 326.0
DTH2_k127_4080453_3 Response regulator receiver K03413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001258 255.0
DTH2_k127_4080453_4 PFAM Zinc iron permease K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000261 246.0
DTH2_k127_4168908_0 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 590.0
DTH2_k127_4168908_1 PFAM Signal transduction response regulator, receiver K07660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 422.0
DTH2_k127_4168908_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 348.0
DTH2_k127_4168908_3 Signal transduction histidine kinase K07637 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000005037 203.0
DTH2_k127_4168908_4 - - - - 0.000000000000000000000000004272 115.0
DTH2_k127_4168908_5 peptidase - - - 0.0000000000000000000003823 100.0
DTH2_k127_4186663_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 7.601e-243 756.0
DTH2_k127_4186663_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.00000000000000000000008835 100.0
DTH2_k127_4209561_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 - 6.2.1.5,6.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 588.0
DTH2_k127_4209561_1 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000001934 235.0
DTH2_k127_4209561_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 - 6.2.1.5,6.2.1.9 0.000000000000001163 77.0
DTH2_k127_4220170_0 PFAM Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 411.0
DTH2_k127_4220170_1 PFAM Heat shock protein DnaJ, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000003175 222.0
DTH2_k127_4220170_2 Diguanylate cyclase - - - 0.00000000000000000000000000002213 124.0
DTH2_k127_4220170_3 PFAM Transposase, IS66 K07484 - - 0.00000000006159 62.0
DTH2_k127_4220170_4 PFAM Transposase, IS66 K07484 - - 0.0001318 46.0
DTH2_k127_427352_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1154.0
DTH2_k127_427352_1 repeat protein - - - 8.577e-228 713.0
DTH2_k127_427352_2 Protein of unknown function (DUF465) K09794 - - 0.0000000000000000000000000000002162 124.0
DTH2_k127_4275865_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 2.375e-230 721.0
DTH2_k127_4275865_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 559.0
DTH2_k127_4282183_0 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 539.0
DTH2_k127_4282183_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 343.0
DTH2_k127_4282183_2 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 - 3.1.1.85 0.0000000000000000000000000000000000000000000000000000001205 198.0
DTH2_k127_4305275_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0 1034.0
DTH2_k127_4312693_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 7.885e-249 777.0
DTH2_k127_4312693_1 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 488.0
DTH2_k127_4312693_2 Pfam Aminotransferase class I and II K02225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 424.0
DTH2_k127_4312693_3 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 408.0
DTH2_k127_4312693_4 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001077 269.0
DTH2_k127_4312693_5 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000002331 245.0
DTH2_k127_4312693_6 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000006703 138.0
DTH2_k127_4312693_7 Nitroreductase family K02303,K04719 - 1.13.11.79,2.1.1.107 0.0000000000000135 73.0
DTH2_k127_4345669_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1506.0
DTH2_k127_4345669_1 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009058 471.0
DTH2_k127_4345669_2 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 466.0
DTH2_k127_4345669_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004269 277.0
DTH2_k127_4345669_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000001249 175.0
DTH2_k127_4345669_5 Type II secretion system K02653 - - 0.000000000000000000000000000000000000000000005204 164.0
DTH2_k127_4345670_0 Putative diguanylate phosphodiesterase - - - 4.786e-203 637.0
DTH2_k127_4345670_1 - - - - 0.000000000000000000000000000000000000000000001273 169.0
DTH2_k127_4345670_2 - - - - 0.0000000000002467 70.0
DTH2_k127_4349526_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 592.0
DTH2_k127_4349526_1 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000205 280.0
DTH2_k127_4349526_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006861 267.0
DTH2_k127_4349526_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000829 256.0
DTH2_k127_4349526_4 Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000000000000003712 226.0
DTH2_k127_4355583_0 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 386.0
DTH2_k127_4355583_1 type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 378.0
DTH2_k127_4355583_2 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001862 237.0
DTH2_k127_436697_0 Belongs to the GSP D family K02453 - - 0.0 1140.0
DTH2_k127_436697_1 pfkB family carbohydrate kinase K00852,K00856 - 2.7.1.15,2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 592.0
DTH2_k127_436697_2 carbon utilization - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 283.0
DTH2_k127_436697_3 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001335 265.0
DTH2_k127_436697_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005776 247.0
DTH2_k127_436697_5 Type II secretory pathway, pseudopilin - - - 0.000000000000000000000000000000000000000000000000000000000000000004645 231.0
DTH2_k127_436697_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000009552 226.0
DTH2_k127_436697_7 PFAM type II secretion system protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000000001165 207.0
DTH2_k127_436697_8 PFAM Transposase DDE domain - - - 0.0000000000000000000000000001183 115.0
DTH2_k127_4415627_0 Competence protein ComEC Rec2 K02238 - - 0.0 1066.0
DTH2_k127_4415627_1 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 7.043e-312 956.0
DTH2_k127_4415627_2 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 521.0
DTH2_k127_4415627_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 317.0
DTH2_k127_4415627_4 Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway K03181 - 4.1.3.40 0.000000000000002002 76.0
DTH2_k127_4514020_0 dehydrogenase, E1 component K00164 - 1.2.4.2 3.177e-202 631.0
DTH2_k127_4514020_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 546.0
DTH2_k127_4514020_2 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 537.0
DTH2_k127_4516984_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 5.25e-299 917.0
DTH2_k127_4516984_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 - 6.2.1.5,6.2.1.9 3.179e-235 730.0
DTH2_k127_4516984_2 Belongs to the HpcH HpaI aldolase family K01644,K08691 - 4.1.3.24,4.1.3.25,4.1.3.34 4.565e-198 619.0
DTH2_k127_4516984_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902,K08692 - 6.2.1.5,6.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 574.0
DTH2_k127_4516984_4 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 481.0
DTH2_k127_4516984_5 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001354 261.0
DTH2_k127_4541283_0 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0 1508.0
DTH2_k127_4541283_1 PFAM aminotransferase, class I K14260 - 2.6.1.2,2.6.1.66 3.828e-198 619.0
DTH2_k127_4541283_2 - - - - 0.0000000000000000000000000000000000000000000000592 171.0
DTH2_k127_4567770_0 Thymidine phosphorylase K00758 - 2.4.2.4 3.72e-244 759.0
DTH2_k127_4567770_1 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008935 319.0
DTH2_k127_4569623_0 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 6.34e-224 701.0
DTH2_k127_4569623_1 Inositol monophosphatase K01082,K01092 - 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 468.0
DTH2_k127_4569623_2 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 371.0
DTH2_k127_4569623_3 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 365.0
DTH2_k127_4569623_4 Ferritin-like domain K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 299.0
DTH2_k127_4569623_5 TrkA-N domain protein K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007865 249.0
DTH2_k127_4569623_6 Integrase core domain K07497 - - 0.00000000001145 68.0
DTH2_k127_4569623_7 PFAM Integrase catalytic region K07497 - - 0.000003396 49.0
DTH2_k127_4569623_8 PFAM transposase IS3 IS911 family protein K07483 - - 0.000008618 52.0
DTH2_k127_4644658_0 Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005398 506.0
DTH2_k127_4644658_1 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 329.0
DTH2_k127_4644658_2 Cytochrome P460 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 301.0
DTH2_k127_4644658_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003526 224.0
DTH2_k127_4644658_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000005193 206.0
DTH2_k127_4644658_5 Aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000003232 201.0
DTH2_k127_4644658_6 - - - - 0.0000000000000000000000000000000000000000000000001109 179.0
DTH2_k127_4644658_7 Protein of unknown function (DUF3460) - - - 0.0000000000000000000000001241 107.0
DTH2_k127_4644658_8 Receptor K02014 - - 0.0000000000000000000003683 104.0
DTH2_k127_4702494_0 Restriction endonuclease, type I, EcoRI, R subunit Type III, Res subunit, N-terminal K01153 - 3.1.21.3 0.0 1171.0
DTH2_k127_4702494_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 458.0
DTH2_k127_4746663_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 5.754e-233 728.0
DTH2_k127_4746663_1 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 569.0
DTH2_k127_4746663_2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 527.0
DTH2_k127_4746663_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000002287 162.0
DTH2_k127_476903_0 Cell wall hydrolase autolysin K01448 - 3.5.1.28 7.209e-196 621.0
DTH2_k127_476903_1 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 589.0
DTH2_k127_476903_2 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 451.0
DTH2_k127_476903_3 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 355.0
DTH2_k127_476903_4 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000000004573 115.0
DTH2_k127_4775099_0 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 289.0
DTH2_k127_4775099_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 289.0
DTH2_k127_4775099_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000365 273.0
DTH2_k127_4775099_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000002196 67.0
DTH2_k127_4786862_0 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 365.0
DTH2_k127_4786862_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004219 273.0
DTH2_k127_4786862_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000006238 94.0
DTH2_k127_4786862_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000004113 72.0
DTH2_k127_4813540_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 445.0
DTH2_k127_4813540_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008594 289.0
DTH2_k127_4813540_2 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000001944 183.0
DTH2_k127_4840775_0 alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 4.967e-272 840.0
DTH2_k127_4840775_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000004179 219.0
DTH2_k127_4861731_0 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 3.01e-259 805.0
DTH2_k127_4861731_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001638 250.0
DTH2_k127_4861731_2 HNH nucleases - - - 0.000000000000000000000000000000000001755 138.0
DTH2_k127_4861731_3 Helix-hairpin-helix domain - - - 0.00000000000000004168 86.0
DTH2_k127_4861731_4 Domain of unknown function (DUF3362) - - - 0.000000001861 58.0
DTH2_k127_493418_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.125e-286 883.0
DTH2_k127_493418_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 408.0
DTH2_k127_493418_2 PFAM EAL domain, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 324.0
DTH2_k127_4950572_0 PFAM Rieske 2Fe-2S K00499 - 1.14.15.7 8.488e-198 617.0
DTH2_k127_4950572_1 EamA-like transporter family K15270 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 480.0
DTH2_k127_4950572_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001035 253.0
DTH2_k127_4950572_3 SpoIIAA-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000537 234.0
DTH2_k127_4950572_4 PFAM Invasion gene expression up-regulator, SirB - - - 0.00000000000000000000000000000000000000000000000000000000006462 207.0
DTH2_k127_4963076_0 pdz dhr glgf - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 580.0
DTH2_k127_4963076_1 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000003282 259.0
DTH2_k127_4963076_2 Domain of unknown function (DUF3362) - - - 0.00000136 50.0
DTH2_k127_4992114_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 4.691e-300 927.0
DTH2_k127_4992114_1 Bacterial regulatory helix-turn-helix protein, lysR family K03576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002329 277.0
DTH2_k127_4995069_0 Belongs to the DEAD box helicase family - GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - 2.887e-241 750.0
DTH2_k127_4995069_1 Strictosidine synthase K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 512.0
DTH2_k127_4996507_0 Cytidylyltransferase-like - - - 1.805e-249 778.0
DTH2_k127_4996507_1 PFAM Peptidase S1 S6, chymotrypsin Hap K08070 - 1.3.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 354.0
DTH2_k127_5017217_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 3.305e-298 919.0
DTH2_k127_5017217_1 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 519.0
DTH2_k127_5036790_0 CHAD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 594.0
DTH2_k127_5036790_1 TIGRFAM Polyphosphate nucleotide phosphotransferase, PPK2 K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 494.0
DTH2_k127_5063653_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 2.213e-283 878.0
DTH2_k127_5063653_1 NADH:flavin oxidoreductase / NADH oxidase family K10680 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 511.0
DTH2_k127_5063653_2 Putative member of DMT superfamily (DUF486) K09922 - - 0.0000000000000000000000000000000000000000000000000000000002943 203.0
DTH2_k127_509046_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.163e-245 760.0
DTH2_k127_509046_1 synthetase, class II (G H P K01892 - 6.1.1.21 1.194e-234 730.0
DTH2_k127_509046_2 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001251 274.0
DTH2_k127_5093607_0 Domain of unknown function DUF21 - - - 2.776e-243 755.0
DTH2_k127_5093607_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 1.856e-205 642.0
DTH2_k127_5093607_2 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 556.0
DTH2_k127_5093607_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 474.0
DTH2_k127_5093607_4 Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 331.0
DTH2_k127_5093607_5 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 288.0
DTH2_k127_5093607_6 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002186 267.0
DTH2_k127_5093607_7 Predicted small integral membrane protein (DUF2165) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004364 254.0
DTH2_k127_5093607_8 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000004539 238.0
DTH2_k127_5093607_9 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000000000000003879 233.0
DTH2_k127_5109570_0 Vacuole effluxer Atg22 like K06902 - - 4.923e-221 690.0
DTH2_k127_5109570_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008984 284.0
DTH2_k127_5109570_2 PFAM Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000000000000000000000000000000000000000000001091 213.0
DTH2_k127_5109570_3 - - - - 0.000000000000000001024 85.0
DTH2_k127_5159217_0 type II restriction enzyme, methylase - - - 0.0 1254.0
DTH2_k127_5159217_1 Belongs to the peptidase S16 family - - - 0.0 1123.0
DTH2_k127_5159217_2 - - - - 1.338e-202 638.0
DTH2_k127_5226191_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 3.884e-288 888.0
DTH2_k127_5226191_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 583.0
DTH2_k127_5226191_2 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 320.0
DTH2_k127_5226191_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 302.0
DTH2_k127_5226191_4 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000000000000002609 237.0
DTH2_k127_5226191_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000001198 135.0
DTH2_k127_5226191_6 Ribonuclease E/G family K08301 - - 0.00000000000000000000004619 98.0
DTH2_k127_5251909_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component K02004 - - 0.0 1176.0
DTH2_k127_5251909_1 Involved in the biosynthesis of porphyrin-containing compound - - - 2.617e-217 678.0
DTH2_k127_5251909_2 PFAM formate nitrite transporter K02598,K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 435.0
DTH2_k127_5256193_0 Response regulator receiver modulated diguanylate cyclase - - - 1.032e-289 899.0
DTH2_k127_5256193_1 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007653 376.0
DTH2_k127_5256193_2 PFAM TonB-dependent receptor, plug K02014,K16089 - - 0.0000000000000000000000000000005502 124.0
DTH2_k127_5256193_3 Response regulator receiver modulated diguanylate cyclase - - - 0.0000002778 52.0
DTH2_k127_5257913_0 amino acid - - - 6.248e-205 640.0
DTH2_k127_5257913_1 Domain of unknown function (DUF1989) K09967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 394.0
DTH2_k127_5257913_2 Domain of unknown function (DUF1989) K09967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 397.0
DTH2_k127_5257913_3 Biotin lipoyl attachment K01941 - 6.3.4.6 0.00000000000000000000000000000000000001609 145.0
DTH2_k127_527797_0 Phosphate-selective porin O and P K07221 - - 6.3e-322 990.0
DTH2_k127_527797_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006955 555.0
DTH2_k127_527797_2 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 522.0
DTH2_k127_527797_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006451 450.0
DTH2_k127_5286926_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 1.911e-196 614.0
DTH2_k127_5286926_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 362.0
DTH2_k127_5286926_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 350.0
DTH2_k127_5286926_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000000000000001208 201.0
DTH2_k127_5291081_0 Histidine kinase K20974 - 2.7.13.3 4.761e-198 627.0
DTH2_k127_5291081_1 Signal transduction response regulator, receiver K03415 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 516.0
DTH2_k127_5291081_2 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000000001641 186.0
DTH2_k127_5316837_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 486.0
DTH2_k127_5316837_1 Tellurite resistance protein TerB K05801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 427.0
DTH2_k127_5316837_2 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 425.0
DTH2_k127_5316837_3 MlaC protein K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 361.0
DTH2_k127_5316837_4 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 330.0
DTH2_k127_5316837_5 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002631 267.0
DTH2_k127_5316837_6 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000872 178.0
DTH2_k127_5316837_7 Belongs to the BolA IbaG family - - - 0.00000000000000000000000000000000000000005022 152.0
DTH2_k127_5316837_8 transporter antisigma-factor antagonist STAS K07122 - - 0.00000000000000000000000000000000532 130.0
DTH2_k127_5316837_9 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.000004673 49.0
DTH2_k127_5335776_0 Fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 2.108e-221 687.0
DTH2_k127_5335776_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 372.0
DTH2_k127_533753_0 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009086 439.0
DTH2_k127_533753_1 HupE UreJ protein K03192 - - 0.000000000000000000000000000000000000000000000000000000000000000000001342 239.0
DTH2_k127_533753_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000000000000000000003506 162.0
DTH2_k127_5350578_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 1.014e-301 927.0
DTH2_k127_5350578_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 542.0
DTH2_k127_5350578_2 dehydrogenase, E1 component K00164 - 1.2.4.2 0.0000000000000000000000000000000000000001606 150.0
DTH2_k127_537233_0 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 301.0
DTH2_k127_537233_1 Cytochrome c, class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008785 273.0
DTH2_k127_537233_2 PFAM Blue (type 1) copper domain - - - 0.0000000000000000000000000000000000000000000000000000000001088 205.0
DTH2_k127_537233_3 - - - - 0.000000000000000000000000000000009527 130.0
DTH2_k127_5379349_0 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 0.0 1403.0
DTH2_k127_5379349_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 324.0
DTH2_k127_5379349_2 Zeta toxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007409 282.0
DTH2_k127_5379349_3 ParD-like antitoxin of type II bacterial toxin-antitoxin system - - - 0.000000000000000000000000000000000000000002082 159.0
DTH2_k127_538331_0 Belongs to the GPI family K01810 - 5.3.1.9 2.21e-292 904.0
DTH2_k127_538331_1 Cytochrome c - - - 0.000000000000000000000000001536 113.0
DTH2_k127_538331_2 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00009277 45.0
DTH2_k127_5395419_0 TIGRFAM TonB-dependent vitamin B12 receptor K16092 - - 2.645e-311 962.0
DTH2_k127_5395419_1 - - - - 0.0000004165 51.0
DTH2_k127_5447883_0 Acts as a magnesium transporter K06213 - - 2.038e-256 796.0
DTH2_k127_5447883_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 479.0
DTH2_k127_5447883_2 Transposase IS200 like K07491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001274 265.0
DTH2_k127_5447883_3 - - - - 0.000000000000000000000000000000000000004668 149.0
DTH2_k127_5485773_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.486e-219 685.0
DTH2_k127_5485773_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 511.0
DTH2_k127_5485773_2 Preprotein translocase subunit K03210 - - 0.00000000000000000000000000000000000000000000000000009094 190.0
DTH2_k127_5493412_0 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 556.0
DTH2_k127_5493412_1 PFAM Integrase catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006887 269.0
DTH2_k127_5539015_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 1.097e-223 695.0
DTH2_k127_5539015_1 Protein of unknown function (DUF815) K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007752 498.0
DTH2_k127_5539015_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 359.0
DTH2_k127_5539015_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003408 265.0
DTH2_k127_5539015_4 heme binding - - - 0.000000000000000000000000000000000000000000001369 190.0
DTH2_k127_5539015_5 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000000000002961 156.0
DTH2_k127_5539015_7 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000000000002881 91.0
DTH2_k127_5542165_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.085e-289 894.0
DTH2_k127_5542165_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001279 247.0
DTH2_k127_5542165_2 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000000000000000427 173.0
DTH2_k127_5557095_0 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 400.0
DTH2_k127_5557095_1 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 284.0
DTH2_k127_5557095_2 PFAM PHP C-terminal K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.000000000000000000000000000000000000000000004494 164.0
DTH2_k127_5586646_0 Cytochrome c1 - - - 3.82e-251 785.0
DTH2_k127_5606368_0 Dak2 K00863,K05878 - 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 2.09e-262 818.0
DTH2_k127_5606368_1 - - - - 0.000000008589 59.0
DTH2_k127_5622745_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 5.715e-237 734.0
DTH2_k127_5622745_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 592.0
DTH2_k127_5622745_2 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 351.0
DTH2_k127_5622745_3 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000000000000000000006556 108.0
DTH2_k127_5636905_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.0 1020.0
DTH2_k127_5636905_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 483.0
DTH2_k127_5636905_2 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 447.0
DTH2_k127_5636905_3 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008049 346.0
DTH2_k127_5653731_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531,K12955 - 3.6.3.2 1.293e-249 784.0
DTH2_k127_5653731_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 2.922e-234 733.0
DTH2_k127_5653731_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 369.0
DTH2_k127_5653731_3 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000000000000000000000000000006079 235.0
DTH2_k127_5653731_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.00000000000001759 73.0
DTH2_k127_5653731_5 Domain of unknown function (DUF3362) - - - 0.00000000000745 66.0
DTH2_k127_5736522_0 Glycosyltransferase like family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 610.0
DTH2_k127_5736522_1 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 333.0
DTH2_k127_5736522_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000008392 221.0
DTH2_k127_5736522_3 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000008094 186.0
DTH2_k127_5776992_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 4.145e-255 788.0
DTH2_k127_5776992_1 - - - - 0.0000000000000000000000000000000000000000002261 162.0
DTH2_k127_5824554_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 1.936e-263 814.0
DTH2_k127_5824554_1 The glycine cleavage system catalyzes the degradation of glycine K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 1.153e-218 681.0
DTH2_k127_5824554_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 598.0
DTH2_k127_5824554_3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 307.0
DTH2_k127_5824554_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003468 247.0
DTH2_k127_5834114_0 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 409.0
DTH2_k127_5834114_1 MotA/TolQ/ExbB proton channel family K02556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 342.0
DTH2_k127_5834114_2 FlgN protein K02399 - - 0.000000000000000000000000000000000000000000000000000000000000003064 220.0
DTH2_k127_5834114_3 PFAM Anti-sigma-28 factor, FlgM K02398 - - 0.000000000000000000000000000000000000000000005651 166.0
DTH2_k127_5834114_4 Bestrophin, RFP-TM, chloride channel K08994 - - 0.000000003542 58.0
DTH2_k127_5850571_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.06e-255 792.0
DTH2_k127_5850571_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 410.0
DTH2_k127_5850571_2 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 399.0
DTH2_k127_5865838_0 POT family K03305 - - 7.952e-194 616.0
DTH2_k127_5865838_1 ROK family K00845,K00847,K00884 - 2.7.1.2,2.7.1.4,2.7.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 503.0
DTH2_k127_5865838_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000003839 235.0
DTH2_k127_5865838_3 - - - - 0.000000000000000000000000004909 109.0
DTH2_k127_5896818_0 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 376.0
DTH2_k127_5896818_1 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000000000000000000000000005169 255.0
DTH2_k127_5896818_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000119 167.0
DTH2_k127_5926803_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 539.0
DTH2_k127_5926803_1 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 467.0
DTH2_k127_5926803_2 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009006 308.0
DTH2_k127_5926803_3 - - - - 0.000000000000000000000000000000006027 128.0
DTH2_k127_5976209_0 Na H antiporter NhaC K03315 - - 6.306e-233 728.0
DTH2_k127_5976209_1 SelR domain K07305,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003143 278.0
DTH2_k127_5976209_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000004982 178.0
DTH2_k127_5976209_3 Protein of unknown function (DUF465) K09794 - - 0.00000009445 53.0
DTH2_k127_5996955_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 605.0
DTH2_k127_5996955_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 478.0
DTH2_k127_5996955_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000000005831 229.0
DTH2_k127_6000_0 PFAM Chemotaxis methyl-accepting receptor, signalling K03406,K03776,K05874 - - 5.644e-263 820.0
DTH2_k127_6000_1 Uncharacterized protein conserved in bacteria (DUF2130) - - - 4.59e-233 726.0
DTH2_k127_6000_2 PFAM thioesterase superfamily K19222 - 3.1.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 308.0
DTH2_k127_6000_3 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000005157 179.0
DTH2_k127_6000_4 - - - - 0.0000000000000000000000000000000000000174 149.0
DTH2_k127_600241_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 492.0
DTH2_k127_600241_1 PFAM aminotransferase, class I K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 481.0
DTH2_k127_600241_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 348.0
DTH2_k127_6007373_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 501.0
DTH2_k127_6007373_1 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 464.0
DTH2_k127_60442_0 SMART Diguanylate phosphodiesterase - - - 6.758e-230 724.0
DTH2_k127_60442_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000001656 192.0
DTH2_k127_604811_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 2.644e-271 838.0
DTH2_k127_604811_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 1.628e-199 629.0
DTH2_k127_604811_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002354 231.0
DTH2_k127_604811_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000002826 213.0
DTH2_k127_604811_4 Tetratricopeptide repeat-like domain - - - 0.00000000001648 64.0
DTH2_k127_6071662_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 544.0
DTH2_k127_6071662_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000004564 214.0
DTH2_k127_6104097_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 3.777e-264 819.0
DTH2_k127_6104097_1 MacB-like periplasmic core domain K02004 - - 1.159e-220 689.0
DTH2_k127_6104097_10 Phosphopantetheine attachment site - - - 0.0000000000000000000000001375 108.0
DTH2_k127_6104097_11 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.00000000000000000000003167 99.0
DTH2_k127_6104097_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 581.0
DTH2_k127_6104097_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 556.0
DTH2_k127_6104097_4 Beta-lactamase enzyme family K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 430.0
DTH2_k127_6104097_5 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 353.0
DTH2_k127_6104097_6 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 338.0
DTH2_k127_6104097_7 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000000000000000000000000000007193 194.0
DTH2_k127_6104097_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000001022 186.0
DTH2_k127_6104097_9 - - - - 0.000000000000000000000000000000005065 128.0
DTH2_k127_6108477_0 DNA polymerase III (Delta subunit) K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 518.0
DTH2_k127_6108477_1 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004108 258.0
DTH2_k127_6108477_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000005394 176.0
DTH2_k127_6113859_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 1.799e-230 717.0
DTH2_k127_6113859_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 477.0
DTH2_k127_6113859_2 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003656 263.0
DTH2_k127_6113859_3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.0000000000000000000000000000000000109 138.0
DTH2_k127_6124783_0 PFAM Aminoacyl-tRNA synthetase, class Ib K01867 - 6.1.1.2 1.565e-261 806.0
DTH2_k127_6124783_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 389.0
DTH2_k127_6124783_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000001798 241.0
DTH2_k127_6124783_3 manually curated - - - 0.0000000000000000000000000000000000000000000000002887 178.0
DTH2_k127_6124783_4 COGs COG3293 - - - 0.0000000000000000000009386 94.0
DTH2_k127_6124783_6 COG0501 Zn-dependent protease with chaperone function - - - 0.0000002131 63.0
DTH2_k127_6151682_0 Bacterial regulatory helix-turn-helix protein, lysR family K13634 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 386.0
DTH2_k127_6151682_1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381,K00392 - 1.8.1.2,1.8.7.1 0.0000000000000000000000000000000000000000000000000000000000001601 213.0
DTH2_k127_6151682_2 - - - - 0.000000000000000000000000000000000000001574 147.0
DTH2_k127_6179754_0 TIGRFAM type I secretion outer membrane protein, TolC K12538 - - 3.57e-220 689.0
DTH2_k127_6179754_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 3.233e-219 686.0
DTH2_k127_6179754_2 TIGRFAM Type I secretion membrane fusion protein, HlyD K02022,K12537,K12542 - - 1.49e-213 669.0
DTH2_k127_6179754_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 607.0
DTH2_k127_6179754_4 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 340.0
DTH2_k127_6179754_5 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 339.0
DTH2_k127_6179754_6 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 0.00001734 49.0
DTH2_k127_6180256_0 malic enzyme K00029 - 1.1.1.40 4.819e-239 743.0
DTH2_k127_6180256_1 TIGRFAM Diguanylate cyclase - - - 2.247e-229 718.0
DTH2_k127_6180256_2 TIGRFAM Phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 444.0
DTH2_k127_6185615_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1155.0
DTH2_k127_6185615_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 466.0
DTH2_k127_6185615_2 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000000000000000704 160.0
DTH2_k127_6185615_3 PFAM Transposase, IS4-like K07481 - - 0.0000000000000000001504 94.0
DTH2_k127_6185615_4 His Kinase A (phosphoacceptor) domain - - - 0.0006591 45.0
DTH2_k127_6223999_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 2.462e-250 775.0
DTH2_k127_6223999_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 2.097e-212 664.0
DTH2_k127_6223999_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 583.0
DTH2_k127_6223999_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 527.0
DTH2_k127_6223999_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 398.0
DTH2_k127_6223999_5 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 297.0
DTH2_k127_6223999_6 CreA protein K05805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002917 246.0
DTH2_k127_6227972_0 Protein of unknown function (DUF3570) - - - 0.0 1081.0
DTH2_k127_6227972_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 0.0 1024.0
DTH2_k127_6227972_2 argininosuccinate lyase K01755 - 4.3.2.1 1.804e-263 816.0
DTH2_k127_6227972_3 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 517.0
DTH2_k127_6227972_4 Fructosamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 466.0
DTH2_k127_6227972_5 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 364.0
DTH2_k127_6243142_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 5.263e-280 866.0
DTH2_k127_6243142_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007283 271.0
DTH2_k127_6243142_2 Belongs to the transcriptional regulatory Fis family K03557 - - 0.0000000000000000000000000000000000009139 139.0
DTH2_k127_6243142_3 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000455 132.0
DTH2_k127_6245701_0 M3B, thimet oligopeptidase F K01414 - 3.4.24.70 1.58e-216 676.0
DTH2_k127_6245701_1 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 414.0
DTH2_k127_624777_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 6.332e-200 627.0
DTH2_k127_624777_1 TIGRFAM Pilus biogenesis stability type IV, PilW K02656 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 382.0
DTH2_k127_624777_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000001746 260.0
DTH2_k127_624777_3 Domain of unknown function (DUF4115) K15539 - - 0.000000000000004712 79.0
DTH2_k127_624777_4 FecR protein - - - 0.000000000001779 67.0
DTH2_k127_6320699_0 PFAM Magnesium chelatase, ChlI subunit K07391 - - 1.072e-287 890.0
DTH2_k127_6320699_1 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 358.0
DTH2_k127_6320699_2 Membrane fusogenic activity K09806 - - 0.000000000000000000000000000000018 129.0
DTH2_k127_6325318_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1942.0
DTH2_k127_6325318_1 Peptidase family U32 C-terminal domain K08303 - - 3.609e-283 872.0
DTH2_k127_6325318_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 449.0
DTH2_k127_6325318_3 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 338.0
DTH2_k127_6325318_4 response regulator K07657 - - 0.000000000000000000000000000000000000002176 148.0
DTH2_k127_6338091_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.501e-241 749.0
DTH2_k127_6338091_1 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004914 259.0
DTH2_k127_6338091_2 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000000000000000000005972 173.0
DTH2_k127_6338091_3 Binds single-stranded DNA at the primosome assembly site (PAS) K02686 - - 0.000000000000000000000000000000000005278 139.0
DTH2_k127_6343208_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0 1082.0
DTH2_k127_6343208_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 1.782e-223 700.0
DTH2_k127_6343208_2 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 350.0
DTH2_k127_6343208_3 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000000008376 166.0
DTH2_k127_6343208_4 - - - - 0.00000000000000000000000000000000000004049 143.0
DTH2_k127_6387587_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 556.0
DTH2_k127_6387587_1 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 381.0
DTH2_k127_6406955_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 3.321e-218 678.0
DTH2_k127_6406955_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 443.0
DTH2_k127_6406955_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000004952 94.0
DTH2_k127_6406955_3 Domain of unknown function (DUF3362) - - - 0.0000007238 51.0
DTH2_k127_6413543_0 Beta-Casp domain K07576 - - 6.351e-253 785.0
DTH2_k127_6413543_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 4.307e-240 748.0
DTH2_k127_6413543_2 PFAM Modulator of Rho-dependent transcription termination K19000 - - 0.00000000000000000000000000000000001504 136.0
DTH2_k127_6413543_3 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.000000000000000726 78.0
DTH2_k127_6421759_0 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 4.248e-209 652.0
DTH2_k127_6421759_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 572.0
DTH2_k127_6421759_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 479.0
DTH2_k127_6421759_3 RNase_H superfamily - - - 0.00000000000000002725 81.0
DTH2_k127_6488985_0 DNA mismatch repair protein MutS - - - 3.797e-283 876.0
DTH2_k127_6488985_1 Uncharacterised protein family (UPF0093) K08973 - - 0.0000000000000000000000000000000000000000000001856 168.0
DTH2_k127_6524671_0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 - 4.2.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 313.0
DTH2_k127_6524671_1 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 - 1.13.11.53,1.13.11.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006456 284.0
DTH2_k127_6524671_2 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 - 3.1.3.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000287 268.0
DTH2_k127_6534938_0 TonB-dependent Receptor Plug Domain K02014 - - 1.34e-222 690.0
DTH2_k127_6534938_1 Glucose / Sorbosone dehydrogenase K21430 - - 1.018e-211 662.0
DTH2_k127_6580917_0 DNA mismatch repair protein MutS - - - 0.0 1000.0
DTH2_k127_6580917_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000003457 153.0
DTH2_k127_6589672_0 PFAM Aminotransferase, class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 521.0
DTH2_k127_6589672_1 Glycosyl transferase family 4 K13007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 441.0
DTH2_k127_6589672_2 Polysaccharide biosynthesis protein - - - 0.00000003294 55.0
DTH2_k127_6596116_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 1.233e-252 783.0
DTH2_k127_6596116_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 347.0
DTH2_k127_6596116_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000003948 128.0
DTH2_k127_6600996_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1969.0
DTH2_k127_6600996_1 RelE-like toxin of type II toxin-antitoxin system HigB - - - 0.000000000003528 67.0
DTH2_k127_6610809_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1020.0
DTH2_k127_6610809_1 Peptidase family M23 K08259 - 3.4.24.75 0.0000000000000000000000000000005762 121.0
DTH2_k127_6625907_0 Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor K03406,K03776 - - 2.165e-256 802.0
DTH2_k127_6625907_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001412 244.0
DTH2_k127_6625907_2 Cytochrome C oxidase, cbb3-type, subunit III K12263 - - 0.000000000000000000006638 92.0
DTH2_k127_6658289_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 8.387e-229 718.0
DTH2_k127_6658289_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000002228 156.0
DTH2_k127_6658289_2 NlpB/DapX lipoprotein K07287 - - 0.00000000000000000000000000000000000009282 154.0
DTH2_k127_667009_0 PFAM Multicopper oxidase, type - - - 1.193e-233 724.0
DTH2_k127_667009_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K18094 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 502.0
DTH2_k127_667009_2 AcrB/AcrD/AcrF family K03296,K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 378.0
DTH2_k127_6756686_0 ADP-ribosylglycohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 496.0
DTH2_k127_6756686_1 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 477.0
DTH2_k127_6756686_2 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000007583 133.0
DTH2_k127_6756686_3 Trm112p-like protein K09791 - - 0.0000000000000000000000000000001447 123.0
DTH2_k127_6807690_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 6.474e-208 647.0
DTH2_k127_6807690_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007967 337.0
DTH2_k127_6807690_2 CRS1_YhbY K07574 - - 0.00000000000000000000000000000000000000000000000003095 180.0
DTH2_k127_6807690_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000572 92.0
DTH2_k127_6818061_0 extracellular solute-binding protein, family 5 - - - 1.025e-197 621.0
DTH2_k127_6818061_1 Peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 472.0
DTH2_k127_6818061_2 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 469.0
DTH2_k127_685043_0 Protein of unknown function (DUF3422) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 413.0
DTH2_k127_685043_1 50S ribosome-binding GTPase K06946 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 383.0
DTH2_k127_685043_2 Outer membrane lipoprotein Slp family K07285 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000519 261.0
DTH2_k127_6861399_0 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 2.111e-258 799.0
DTH2_k127_6861399_1 FAD linked oxidases, C-terminal domain K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 6.121e-197 617.0
DTH2_k127_6861399_2 SMART Peptidoglycan-binding Lysin subgroup K16291 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 578.0
DTH2_k127_6861399_3 PFAM 6-phosphogluconate dehydrogenase, NAD-binding K00042 - 1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 492.0
DTH2_k127_6861399_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 486.0
DTH2_k127_6861399_5 Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 313.0
DTH2_k127_6861399_6 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000228 253.0
DTH2_k127_6861399_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000006962 228.0
DTH2_k127_6861399_8 Thiamine monophosphate synthase - - - 0.000000000000000000000000000000000000000000000001248 185.0
DTH2_k127_6861399_9 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000000000000000002803 140.0
DTH2_k127_6879589_0 Histidine kinase K03407 GO:0003674,GO:0005488,GO:0005515,GO:0019904 2.7.13.3 0.0 1031.0
DTH2_k127_6879589_1 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 379.0
DTH2_k127_6879589_2 PFAM CheW-like protein K03408 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003232 252.0
DTH2_k127_6893908_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 4.947e-222 690.0
DTH2_k127_6893908_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 309.0
DTH2_k127_6893908_2 Putative regulatory protein - - - 0.00000000000000000000000000000000001723 138.0
DTH2_k127_6912454_0 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 488.0
DTH2_k127_6912454_1 Periplasmic sensor hybrid histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 345.0
DTH2_k127_6912454_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000001845 90.0
DTH2_k127_6912454_3 to AA sequence GI 30249492 - - - 0.0000000111 55.0
DTH2_k127_6921283_0 acetyltransferase - - - 2.17e-215 675.0
DTH2_k127_6921283_1 MobA-like NTP transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 303.0
DTH2_k127_6921283_2 - - - - 0.00000000000000000000000000000000000000000000000000009995 187.0
DTH2_k127_6921283_3 DNA polymerase III, epsilon subunit K02342 - 2.7.7.7 0.0005817 44.0
DTH2_k127_6935563_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 3.756e-239 739.0
DTH2_k127_6935563_1 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 556.0
DTH2_k127_6935563_2 low molecular weight K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.00000000000000000000000000000000000000000000000000000000000000000002435 233.0
DTH2_k127_6977340_0 Chromate transporter K07240 - - 8.226e-201 634.0
DTH2_k127_6977340_1 Belongs to the glycosyl hydrolase 26 family - - - 0.00000000000000000000000000007928 117.0
DTH2_k127_6978558_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 7.619e-239 740.0
DTH2_k127_6978558_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008311 381.0
DTH2_k127_6978558_2 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 329.0
DTH2_k127_6978558_3 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 331.0
DTH2_k127_6978558_4 succinate dehydrogenase, cytochrome b subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000003027 195.0
DTH2_k127_6978558_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.000000000000000000000000000000000000000006103 159.0
DTH2_k127_6978558_6 - - - - 0.000008012 50.0
DTH2_k127_6980203_0 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 541.0
DTH2_k127_6980203_1 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 455.0
DTH2_k127_6980203_2 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006075 319.0
DTH2_k127_6980203_3 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000000000000000000000033 189.0
DTH2_k127_6980203_4 BON domain - - - 0.000000000000000000000000000000000000009185 148.0
DTH2_k127_6980203_5 Domain of unknown function (DUF3362) - - - 0.0000002931 52.0
DTH2_k127_6985089_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1224.0
DTH2_k127_6985089_1 PFAM aminotransferase, class I K00812 - 2.6.1.1 1.74e-233 725.0
DTH2_k127_6985089_10 Belongs to the peptidase S8 family - - - 0.00000002088 65.0
DTH2_k127_6985089_12 Transposase DDE domain - - - 0.0000004509 57.0
DTH2_k127_6985089_13 Domain of unknown function (DUF3362) - - - 0.000047 50.0
DTH2_k127_6985089_14 PFAM Transposase, IS66 K07484 - - 0.0003245 43.0
DTH2_k127_6985089_2 PFAM Lytic transglycosylase-like, catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006477 471.0
DTH2_k127_6985089_3 Subtilase family K08651,K14645 - 3.4.21.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 404.0
DTH2_k127_6985089_4 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 320.0
DTH2_k127_6985089_5 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005466 314.0
DTH2_k127_6985089_6 PFAM Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008432 290.0
DTH2_k127_6985089_7 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02403 - - 0.0000000000000000000000000000000000000000000002755 170.0
DTH2_k127_6985089_8 Esterase PHB depolymerase - - - 0.000000000000000000003329 104.0
DTH2_k127_6985089_9 Pfam Transposase DDE domain - - - 0.000000000000000000005194 96.0
DTH2_k127_700640_0 ABC transporter K06147,K18893 - - 0.0 1043.0
DTH2_k127_700640_1 Enoyl-CoA hydratase isomerase K19640 - - 5.095e-286 890.0
DTH2_k127_700640_2 TraB family - - - 4.016e-228 711.0
DTH2_k127_700640_3 AIR synthase related protein, N-terminal domain K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 350.0
DTH2_k127_700640_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007969 226.0
DTH2_k127_700640_5 PFAM Integrase, catalytic region - - - 0.00000009516 54.0
DTH2_k127_700640_6 PFAM Integrase, catalytic region - - - 0.00003259 46.0
DTH2_k127_7041443_0 May be involved in recombinational repair of damaged DNA K03631 - - 6.29e-230 724.0
DTH2_k127_7041443_1 Belongs to the agmatine deiminase family - - - 0.000000000000000000000000002701 114.0
DTH2_k127_713088_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 7.649e-236 730.0
DTH2_k127_713088_1 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 503.0
DTH2_k127_713088_2 low molecular weight K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003144 272.0
DTH2_k127_7141245_0 ABC transporter C-terminal domain K15738 - - 0.0 1052.0
DTH2_k127_7141245_1 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 565.0
DTH2_k127_7141245_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 397.0
DTH2_k127_7141245_3 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 378.0
DTH2_k127_7141245_4 Part of a membrane complex involved in electron transport K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 297.0
DTH2_k127_7141245_5 Domain of unknown function (DUF1841) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005199 251.0
DTH2_k127_7141245_6 PFAM Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000000000003989 208.0
DTH2_k127_7141245_7 Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000007607 190.0
DTH2_k127_7141245_8 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000003163 63.0
DTH2_k127_7159705_0 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 451.0
DTH2_k127_7159705_1 ArsC family K00537 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000006054 185.0
DTH2_k127_7159705_2 Diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000001936 158.0
DTH2_k127_7177171_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 5.776e-233 726.0
DTH2_k127_7177171_1 Domain of unknown function (DUF4124) - - - 0.000000000001344 69.0
DTH2_k127_7193488_0 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 392.0
DTH2_k127_7193488_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 360.0
DTH2_k127_7193488_2 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000006952 172.0
DTH2_k127_7199007_0 fatty acid desaturase - - - 1.25e-204 643.0
DTH2_k127_7199007_1 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 400.0
DTH2_k127_7199007_2 Histidine triad (HIT) protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001596 252.0
DTH2_k127_7199007_3 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000003046 244.0
DTH2_k127_7199007_4 PFAM Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000002252 185.0
DTH2_k127_7199007_5 Type III restriction enzyme res subunit K01156 - 3.1.21.5 0.000000000000000000000000000000000000791 140.0
DTH2_k127_7199007_6 Cold shock protein domain K03704 - - 0.000000000000000000000000000000000002408 138.0
DTH2_k127_7224211_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 4.44e-293 910.0
DTH2_k127_7224211_1 PFAM Orotidine 5'-phosphate decarboxylase K08093 - 4.1.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 365.0
DTH2_k127_7224211_2 SIS domain K08094 - 5.3.1.27 0.0000000000000000000000000000000004052 134.0
DTH2_k127_7224211_3 FeoC like transcriptional regulator - - - 0.0000000000000000000000000002829 117.0
DTH2_k127_7232449_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 4.328e-320 981.0
DTH2_k127_7232449_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 471.0
DTH2_k127_7232449_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 401.0
DTH2_k127_7232449_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 327.0
DTH2_k127_7232449_4 Thioredoxin-like - - - 0.00000000000000000000000001452 110.0
DTH2_k127_7232946_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.293e-305 938.0
DTH2_k127_7232946_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 539.0
DTH2_k127_7244342_0 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 486.0
DTH2_k127_7244342_1 Uncharacterized protein family, UPF0114 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 346.0
DTH2_k127_7244342_3 Domain of unknown function (DUF4143) K07133 - - 0.000000004847 57.0
DTH2_k127_7244377_0 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 554.0
DTH2_k127_7244377_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 464.0
DTH2_k127_7244377_2 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007383 239.0
DTH2_k127_7244377_3 Sigma 54 modulation protein K05808 - - 0.000000000000000000000000000000000000000000000000000000006936 199.0
DTH2_k127_7244377_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000001752 171.0
DTH2_k127_7244377_5 Domain of unknown function (DUF3362) - - - 0.00001821 46.0
DTH2_k127_724688_0 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381,K00392 - 1.8.1.2,1.8.7.1 1.282e-278 858.0
DTH2_k127_724688_1 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 310.0
DTH2_k127_724688_2 PFAM Uncharacterised conserved protein UCP030820 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 301.0
DTH2_k127_726186_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 475.0
DTH2_k127_726186_1 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009694 463.0
DTH2_k127_726186_2 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 376.0
DTH2_k127_726186_4 - - - - 0.000000005857 58.0
DTH2_k127_7273541_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1133.0
DTH2_k127_7273541_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 392.0
DTH2_k127_7273541_2 phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 334.0
DTH2_k127_7273541_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000000000000000000000008089 209.0
DTH2_k127_7285005_0 Signal transduction histidine kinase K15011 - 2.7.13.3 1.164e-230 720.0
DTH2_k127_7285005_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006579 596.0
DTH2_k127_7285005_2 TIGRFAM glycine oxidase ThiO K03153 - 1.4.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 476.0
DTH2_k127_7285005_3 Response regulator receiver K15012 - - 0.00000000000000000000000000000000000000000000000000000000000000000003044 233.0
DTH2_k127_7287733_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.42e-265 824.0
DTH2_k127_7287733_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 2.436e-242 756.0
DTH2_k127_7287733_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 2.115e-227 711.0
DTH2_k127_7287733_3 Peptidoglycan polymerase that is essential for cell division K03588 - - 1.23e-208 652.0
DTH2_k127_7287733_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 366.0
DTH2_k127_7287733_5 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008296 294.0
DTH2_k127_7339984_0 PFAM Peptidyl-prolyl cis-trans isomerase, cyclophilin-type K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 380.0
DTH2_k127_7339984_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 309.0
DTH2_k127_7339984_2 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000002176 218.0
DTH2_k127_7339984_3 PD-(D/E)XK nuclease superfamily K01144 - 3.1.11.5 0.0000000000000000000000000000000000002132 143.0
DTH2_k127_738126_0 MltA specific insert domain K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 522.0
DTH2_k127_738126_1 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 408.0
DTH2_k127_738126_2 Belongs to the peptidase S1C family K04691,K04772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 297.0
DTH2_k127_7417565_0 Molybdopterin oxidoreductase Fe4S4 domain K00336 - 1.6.5.3 4.047e-314 966.0
DTH2_k127_7417565_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.301e-200 624.0
DTH2_k127_7436522_0 DNA polymerase X family K02347 - - 4.692e-250 776.0
DTH2_k127_7436522_1 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 361.0
DTH2_k127_7436522_2 - - - - 0.00000005622 55.0
DTH2_k127_7474131_0 TrkA-N domain protein K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 529.0
DTH2_k127_7474131_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007052 475.0
DTH2_k127_7479725_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 400.0
DTH2_k127_7479725_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 364.0
DTH2_k127_7479725_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 295.0
DTH2_k127_7479725_3 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008898 276.0
DTH2_k127_7479725_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001511 239.0
DTH2_k127_749588_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.985e-244 760.0
DTH2_k127_749588_1 L-serine dehydratase single chain form K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003634 267.0
DTH2_k127_7497221_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 581.0
DTH2_k127_7497221_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 518.0
DTH2_k127_7497221_2 HpcH/HpaI aldolase/citrate lyase family K01630 - 4.1.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 479.0
DTH2_k127_7497221_3 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 368.0
DTH2_k127_7497221_4 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 303.0
DTH2_k127_7497221_5 Cytidylyltransferase K00979 - 2.7.7.38 0.00000005473 53.0
DTH2_k127_7502872_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 454.0
DTH2_k127_7502872_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 284.0
DTH2_k127_7502872_2 TatD related DNase K03424 - - 0.0000000000000000000000006601 104.0
DTH2_k127_7502872_3 Alginate export - - - 0.0000006023 54.0
DTH2_k127_7525867_0 type II secretion system protein E K02454 - - 1.339e-298 919.0
DTH2_k127_7525867_1 type II restriction enzyme, methylase - - - 0.000000000000000000003735 93.0
DTH2_k127_7525867_2 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000000001147 75.0
DTH2_k127_7562342_0 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 509.0
DTH2_k127_7562342_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009475 332.0
DTH2_k127_7562342_2 TIGRFAM Methionine sulphoxide reductase B K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000006382 225.0
DTH2_k127_7565865_0 Sodium:alanine symporter family K03310 - - 4.708e-250 776.0
DTH2_k127_7565865_1 nuclease - - - 0.000000000000000000000000000000000000000000000000000000000676 205.0
DTH2_k127_757567_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 443.0
DTH2_k127_757567_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 409.0
DTH2_k127_757567_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007785 276.0
DTH2_k127_757567_3 nitrous-oxide reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000263 216.0
DTH2_k127_757567_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000002446 118.0
DTH2_k127_757567_5 Pfam Transposase DDE domain - - - 0.00000000007741 65.0
DTH2_k127_7586025_0 Amino acid permease - - - 7.557e-248 773.0
DTH2_k127_7586025_1 Rhodanese-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000004242 232.0
DTH2_k127_7586025_2 Metallo-peptidase family M12B Reprolysin-like - - - 0.0000000000000000000000000000000000000000000000000000000296 201.0
DTH2_k127_7588793_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0 1294.0
DTH2_k127_7588793_1 AAA C-terminal domain K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 489.0
DTH2_k127_7588793_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000469 101.0
DTH2_k127_7605205_0 TonB-dependent Receptor Plug Domain K02014 - - 0.0 1133.0
DTH2_k127_7605205_1 TIGRFAM Sodium sulphate symporter K11106,K14445 - - 1.393e-255 792.0
DTH2_k127_7605205_2 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000000001464 141.0
DTH2_k127_7605205_3 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000000004223 131.0
DTH2_k127_7605205_4 - - - - 0.0000000000000000000001147 101.0
DTH2_k127_7621479_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0 1184.0
DTH2_k127_7621479_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 583.0
DTH2_k127_7621479_2 signal recognition particle SRP54 K02404 - - 0.000000000000000000000000000000000000000000000004761 175.0
DTH2_k127_7634691_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 1.462e-218 689.0
DTH2_k127_7634691_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 1.284e-210 666.0
DTH2_k127_7634691_2 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 356.0
DTH2_k127_7634691_3 Tyrosine phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 295.0
DTH2_k127_7634691_4 transcriptional regulator, ArsR - - - 0.000000000000000000000000000000000000000000001633 166.0
DTH2_k127_7634691_5 - - - - 0.0002177 44.0
DTH2_k127_7691352_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 553.0
DTH2_k127_7691352_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000004134 152.0
DTH2_k127_7691896_0 ABC transporter K06020 - 3.6.3.25 1.137e-311 957.0
DTH2_k127_7691896_1 Dimerisation domain of Zinc Transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 355.0
DTH2_k127_7704378_0 PFAM Prenyltransferase squalene oxidase K06045 - 4.2.1.129,5.4.99.17 0.0 1010.0
DTH2_k127_7704378_1 lipid A ABC exporter family, fused ATPase and inner membrane subunits K06147 - - 4.937e-301 931.0
DTH2_k127_7704378_2 PFAM multicopper oxidase type 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 488.0
DTH2_k127_7704378_3 PFAM Multicopper oxidase, type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 348.0
DTH2_k127_7704378_4 Phosphorylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 298.0
DTH2_k127_7706841_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 3.472e-203 636.0
DTH2_k127_7706841_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000004523 216.0
DTH2_k127_7787609_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.7e-198 624.0
DTH2_k127_7787609_1 BT1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 503.0
DTH2_k127_7847496_0 Aconitase C-terminal domain K01681 - 4.2.1.3 5.832e-288 887.0
DTH2_k127_7847496_1 PFAM Alkyl hydroperoxide reductase K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005075 265.0
DTH2_k127_7847496_2 Tetratricopeptide repeat K02200 - - 0.00000000000000000004498 89.0
DTH2_k127_7875927_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 9.835e-316 969.0
DTH2_k127_7913889_0 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 3.066e-217 676.0
DTH2_k127_7913889_1 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 362.0
DTH2_k127_7921854_0 PFAM aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 2.319e-224 698.0
DTH2_k127_7921854_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000003023 128.0
DTH2_k127_8055040_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 1.655e-218 680.0
DTH2_k127_8055040_1 SMART ATPase, AAA type, core K09691 - - 5.06e-203 641.0
DTH2_k127_8055040_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 414.0
DTH2_k127_8055040_3 PFAM ABC-2 type transporter K09690 - - 0.000000000000000000000000000007858 129.0
DTH2_k127_8091000_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1399.0
DTH2_k127_8091000_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000001273 132.0
DTH2_k127_811609_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1400.0
DTH2_k127_811609_1 DeoC/LacD family aldolase K11645 - 4.1.2.13 5.018e-213 663.0
DTH2_k127_811609_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000001006 62.0
DTH2_k127_816725_0 type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 529.0
DTH2_k127_816725_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001527 274.0
DTH2_k127_816725_2 - - - - 0.000000000000000003572 85.0
DTH2_k127_8213965_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1464.0
DTH2_k127_8213965_1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001704 273.0
DTH2_k127_8217810_0 Domain of unknown function (DUF697) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 435.0
DTH2_k127_8217810_1 50S ribosome-binding GTPase K06946 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 374.0
DTH2_k127_8316261_0 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003309 273.0
DTH2_k127_8316261_1 Belongs to the D-alanine--D-alanine ligase family K01921 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 0.0000000000000001436 82.0
DTH2_k127_8341735_0 Two component signalling adaptor domain K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 323.0
DTH2_k127_8341735_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000001301 199.0
DTH2_k127_8341735_2 methyl-accepting chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000000000000005251 193.0
DTH2_k127_8341735_3 Histidine kinase K03407,K13490 - 2.7.13.3 0.000000000000000000000000000000000000000000000000006697 186.0
DTH2_k127_8341735_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000001004 76.0
DTH2_k127_8341735_5 Domain of unknown function (DUF3362) - - - 0.00000001203 56.0
DTH2_k127_840134_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 424.0
DTH2_k127_840134_1 - - - - 0.0000000000000000000000000000000000000000000000000000000009436 207.0
DTH2_k127_840134_2 HIT domain K02503 - - 0.000000000000000000000000000000000000000000000000000000009514 199.0
DTH2_k127_840134_3 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000002672 194.0
DTH2_k127_840134_4 phosphoribosyl-ATP diphosphatase activity K01523 - 3.6.1.31 0.00000000000000000000000000000000000000000000000000005904 187.0
DTH2_k127_840134_5 Heavy metal transport detoxification protein K17686,K19597 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000006909 186.0
DTH2_k127_840134_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000000000000000000000000000000000005552 143.0
DTH2_k127_840134_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000000009201 109.0
DTH2_k127_8401899_0 modulator of DNA gyrase K03592 - - 1.287e-251 781.0
DTH2_k127_8401899_1 RNA polymerase recycling family C-terminal K03580 - - 2.624e-211 662.0
DTH2_k127_8401899_2 Belongs to the UPF0307 family K09889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000686 272.0
DTH2_k127_8401899_3 Predicted methyltransferase regulatory domain - - - 0.0008668 42.0
DTH2_k127_8415199_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1157.0
DTH2_k127_8415199_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 382.0
DTH2_k127_8415199_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 303.0
DTH2_k127_8415199_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000000000000000000002813 199.0
DTH2_k127_8466941_0 TonB-dependent receptor K16090 - - 0.0 1177.0
DTH2_k127_8466941_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 484.0
DTH2_k127_8484493_0 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 338.0
DTH2_k127_8484493_1 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 295.0
DTH2_k127_8484493_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000003733 231.0
DTH2_k127_8489057_0 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 587.0
DTH2_k127_8489057_1 HemY protein N-terminus K02498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 580.0
DTH2_k127_8489057_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 494.0
DTH2_k127_8489057_3 uroporphyrinogen III synthase K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 388.0
DTH2_k127_8489057_4 Thioredoxin-like - - - 0.00000002341 59.0
DTH2_k127_8505168_0 PFAM Peptidase S45, penicillin amidase K01434 - 3.5.1.11 2.925e-235 737.0
DTH2_k127_8513975_0 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 565.0
DTH2_k127_8513975_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 379.0
DTH2_k127_8548618_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 346.0
DTH2_k127_8548618_1 CAAX protease self-immunity - - - 0.000000000000000000002595 95.0
DTH2_k127_8558229_0 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 593.0
DTH2_k127_8558229_1 LppC putative lipoprotein K07121 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 506.0
DTH2_k127_8558229_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 442.0
DTH2_k127_8558229_3 Uncharacterised protein family UPF0102 K07460 - - 0.00000000000000000000000000004441 119.0
DTH2_k127_8558229_4 - - - - 0.0000001182 58.0
DTH2_k127_8581504_0 PFAM restriction modification system DNA specificity domain K01154 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 551.0
DTH2_k127_8581504_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 540.0
DTH2_k127_8581504_2 Two component signalling adaptor domain K02659 - - 0.00000000000000000000000000000000000000000000000000000000007433 207.0
DTH2_k127_8597163_0 SMART ATPase, AAA type, core K06148 - - 1.62e-321 989.0
DTH2_k127_8597163_1 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 5.052e-241 747.0
DTH2_k127_8597163_2 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 315.0
DTH2_k127_8607520_0 DinB superfamily - - - 4.081e-280 860.0
DTH2_k127_8607520_1 PFAM aminotransferase, class I K00842,K14155 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 425.0
DTH2_k127_861139_0 Ammonium transporter K03320,K06580 - - 6.549e-242 752.0
DTH2_k127_861139_1 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000024 260.0
DTH2_k127_861139_2 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007191 248.0
DTH2_k127_861139_3 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.0000000000000000000000000176 110.0
DTH2_k127_8640230_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 447.0
DTH2_k127_8640230_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000000000000000000000000000000000000000006914 190.0
DTH2_k127_8640230_2 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.0000000000000000000000000000000002355 132.0
DTH2_k127_8693222_0 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 2.237e-258 800.0
DTH2_k127_8693222_1 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 456.0
DTH2_k127_8762941_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 466.0
DTH2_k127_8762941_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 396.0
DTH2_k127_8762941_2 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000000000000000000000003764 115.0
DTH2_k127_8763292_0 CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer K09952 - - 0.0 1322.0
DTH2_k127_8763292_1 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K15342 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 490.0
DTH2_k127_8763292_2 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K09951 - - 0.0000000009836 59.0
DTH2_k127_8791147_0 Glutamate-cysteine ligase K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 507.0
DTH2_k127_8791147_1 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 441.0
DTH2_k127_882294_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.571e-318 979.0
DTH2_k127_882294_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 338.0
DTH2_k127_882294_2 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000000000007558 116.0
DTH2_k127_8832702_0 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.0 1159.0
DTH2_k127_8832702_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 297.0
DTH2_k127_8852945_0 protein synthesis factor, GTP-binding K06207 - - 0.0 1077.0
DTH2_k127_8852945_1 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244,K21721 - 1.4.1.1,1.5.1.51,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 484.0
DTH2_k127_8852945_2 - - - - 0.00000000000000000005532 89.0
DTH2_k127_8913948_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0 1127.0
DTH2_k127_8913948_1 Protein of unknown function (DUF2914) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000903 267.0
DTH2_k127_8913948_2 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000004801 211.0
DTH2_k127_8913948_3 TspO/MBR family K05770 - - 0.000000000000000000000000000000000000000000000000000000002992 203.0
DTH2_k127_8913948_4 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000002346 161.0
DTH2_k127_8915282_0 Required for chromosome condensation and partitioning K03529 - - 3.078e-239 760.0
DTH2_k127_8915282_1 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000003441 119.0
DTH2_k127_8924419_0 Thioredoxin K07396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 315.0
DTH2_k127_8924419_1 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 290.0
DTH2_k127_8924419_2 Helix-turn-helix domain - - - 0.000003196 50.0
DTH2_k127_8950106_0 Sodium:dicarboxylate symporter family K11102 - - 4.184e-208 652.0
DTH2_k127_8950106_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 292.0
DTH2_k127_8950106_2 RIO1 family K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000002386 172.0
DTH2_k127_895705_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 447.0
DTH2_k127_895705_1 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 432.0
DTH2_k127_895705_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001882 229.0
DTH2_k127_9022488_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1309.0
DTH2_k127_9022488_1 Glucose / Sorbosone dehydrogenase K21430 - - 9.01e-209 653.0
DTH2_k127_9030281_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1733.0
DTH2_k127_9030281_1 Belongs to the CarA family K01956 - 6.3.5.5 3.054e-225 701.0
DTH2_k127_9030281_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 451.0
DTH2_k127_9030281_3 diol metabolic process K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000000000000000002805 194.0
DTH2_k127_9059860_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0 1169.0
DTH2_k127_9059860_1 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 301.0
DTH2_k127_9059860_2 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000001872 153.0
DTH2_k127_906442_0 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 532.0
DTH2_k127_906442_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 359.0
DTH2_k127_906510_0 transcriptional regulator K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008024 572.0
DTH2_k127_906510_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 536.0
DTH2_k127_906510_2 amino acid - - - 0.000000000000000000000000000000000000000000000653 167.0
DTH2_k127_9073859_0 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 585.0
DTH2_k127_9073859_1 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 330.0
DTH2_k127_9073859_2 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002336 273.0
DTH2_k127_9073859_3 Dihydroorotase, multifunctional complex type K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000004154 182.0
DTH2_k127_9073859_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000000000005587 173.0
DTH2_k127_9073859_5 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000007958 151.0
DTH2_k127_9111211_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 3.947e-250 777.0
DTH2_k127_9111211_1 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 2.26e-236 740.0
DTH2_k127_9111211_2 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005788 569.0
DTH2_k127_9111211_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 422.0
DTH2_k127_9111211_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 344.0
DTH2_k127_9111211_5 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000001963 124.0
DTH2_k127_9120942_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 1.918e-213 666.0
DTH2_k127_9120942_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K00647,K09458 - 2.3.1.179,2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000005452 235.0
DTH2_k127_9120942_2 acyl-CoA dehydrogenase K06445 - - 0.00000000000000000000000000000000000000000000000000000000000004526 214.0
DTH2_k127_9120942_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000001959 118.0
DTH2_k127_9155235_0 Belongs to the peptidase S16 family - - - 1.915e-273 846.0
DTH2_k127_9168255_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 9.345e-247 774.0
DTH2_k127_9200611_0 Selenide, water dikinase K01008 - 2.7.9.3 2.332e-199 628.0
DTH2_k127_9200611_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 337.0
DTH2_k127_9231195_0 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 526.0
DTH2_k127_9231195_1 Peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 487.0
DTH2_k127_9231195_2 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000000000000000000000007811 211.0
DTH2_k127_9231195_3 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000000000000000009798 163.0
DTH2_k127_9231195_4 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.0000000000000002668 78.0
DTH2_k127_9231195_5 - - - - 0.00000000003298 64.0
DTH2_k127_9231195_6 - - - - 0.000005792 49.0
DTH2_k127_9247466_0 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 534.0
DTH2_k127_9247466_1 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 495.0
DTH2_k127_9247466_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 338.0
DTH2_k127_9247466_3 Belongs to the UPF0250 family K09158 - - 0.00000000000000000000000000000000000000000007855 161.0
DTH2_k127_9265964_0 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 496.0
DTH2_k127_9265964_1 Belongs to the peptidase S16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 420.0
DTH2_k127_9265964_2 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000000000000002132 218.0
DTH2_k127_9265964_3 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000000000000000046 134.0
DTH2_k127_9265964_4 Cation efflux family - - - 0.00000000002416 67.0
DTH2_k127_9291018_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 1.664e-229 713.0
DTH2_k127_9291018_1 PFAM Multicopper oxidase, type K04753,K08100,K14588 - 1.3.3.5 2.396e-206 647.0
DTH2_k127_9291018_2 PFAM Methionine biosynthesis MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 380.0
DTH2_k127_9297589_0 Glutaminyl-tRNA synthetase K01886 - 6.1.1.18 5.066e-235 726.0
DTH2_k127_9297589_1 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007538 261.0
DTH2_k127_9297589_2 Domain of unknown function (DUF5062) - - - 0.000000000000000000000000000000000000000000000008863 171.0
DTH2_k127_9297589_3 Nucleotidyltransferase domain - - - 0.0000000000000000000001197 102.0
DTH2_k127_930343_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1197.0
DTH2_k127_930343_1 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 524.0
DTH2_k127_930343_2 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 312.0
DTH2_k127_930343_3 Domain of unknown function (DUF4156) - - - 0.0000000000000000000000000000000000000000001742 162.0
DTH2_k127_930343_4 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000006028 117.0
DTH2_k127_9323340_0 PFAM Squalene phytoene synthase K00801 - 2.5.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 570.0
DTH2_k127_9323340_1 NmrA-like family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 542.0
DTH2_k127_9323340_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000004726 256.0
DTH2_k127_9326282_0 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 295.0
DTH2_k127_9326282_1 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004839 268.0
DTH2_k127_9326282_2 Belongs to the skp family K06142 - - 0.0000000000001321 70.0
DTH2_k127_9329998_0 Tetratricopeptide repeat - - - 5.191e-302 935.0
DTH2_k127_9329998_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000001617 188.0
DTH2_k127_935787_0 Uncharacterized ACR, YdiU/UPF0061 family - - - 1.91e-231 724.0
DTH2_k127_935787_1 Cellulose synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 441.0
DTH2_k127_935787_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 339.0
DTH2_k127_935787_3 PFAM transposase, IS4 family protein K07481 - - 0.0000000000000000000000000000000000000000000000000000000004294 205.0
DTH2_k127_935787_4 - - - - 0.00000000000000000000000000000000000000002225 157.0
DTH2_k127_935787_5 Competence protein ComEA K02237 - - 0.000000000000000000000000000000000002697 140.0
DTH2_k127_935787_6 COG3039 Transposase and inactivated derivatives IS5 family K07481 - - 0.000000000000000000000000000000001801 132.0
DTH2_k127_93598_0 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 7.273e-262 809.0
DTH2_k127_93598_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 355.0
DTH2_k127_936404_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.0 1138.0
DTH2_k127_936404_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 5.698e-198 621.0
DTH2_k127_936404_2 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 440.0
DTH2_k127_936404_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 408.0
DTH2_k127_936404_4 shape-determining protein MreD K03571 - - 0.0000000000000000000000000000000000000000000000000000000003721 207.0
DTH2_k127_9385856_0 DNA helicase K03654 - 3.6.4.12 3.619e-239 742.0
DTH2_k127_9385856_1 TIGRFAM glutamine synthetase, type I K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000003449 229.0
DTH2_k127_940733_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.042e-271 837.0
DTH2_k127_940733_1 succinate dehydrogenase fumarate reductase K00240 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 478.0
DTH2_k127_940733_2 dehydrogenase, E1 component K00164 - 1.2.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003981 434.0
DTH2_k127_940733_3 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000000000000000000000000003947 138.0
DTH2_k127_9419021_0 Flagellar hook-length control protein FliK - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 454.0
DTH2_k127_9419021_1 flagellar protein FliS K02422 - - 0.000000000000000000000000000000000000000000000000000000000000000002271 229.0
DTH2_k127_9419021_2 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.0000000000000000000000000000000000000000000000000003762 186.0
DTH2_k127_9419021_3 Flagellar protein FliT K02423 - - 0.000000000000000000000000000000000000000006569 156.0
DTH2_k127_9419021_4 FlhB HrpN YscU SpaS Family K04061 - - 0.0000000000000000000000000000000008356 133.0
DTH2_k127_9419021_5 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.0000000000000000001755 93.0
DTH2_k127_9429151_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 9.081e-294 908.0
DTH2_k127_9429151_1 SMART Diguanylate phosphodiesterase K13924 - 2.1.1.80,3.1.1.61 1.82e-263 817.0
DTH2_k127_9429151_2 - - - - 0.00000000000000000000000000000000000000000000000001512 180.0
DTH2_k127_9442280_0 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 6.332e-209 655.0
DTH2_k127_9442280_1 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000000000000000000000000000000000003817 141.0
DTH2_k127_9442280_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000004478 102.0
DTH2_k127_9567020_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 1.242e-224 700.0
DTH2_k127_9567020_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 414.0
DTH2_k127_96031_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 1.044e-228 714.0
DTH2_k127_96031_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 397.0
DTH2_k127_96031_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000006027 85.0
DTH2_k127_9606745_0 UvrD REP K03657 - 3.6.4.12 0.0 1190.0
DTH2_k127_9606745_1 TonB-dependent Receptor Plug Domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 574.0
DTH2_k127_9606745_2 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 527.0
DTH2_k127_9622351_0 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 439.0
DTH2_k127_9622351_1 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 411.0
DTH2_k127_9622351_2 4-hydroxybenzoyl-CoA thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000000000000002622 225.0
DTH2_k127_9622351_3 Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000006314 134.0
DTH2_k127_9626654_0 SMART Diguanylate cyclase K13590 - 2.7.7.65 4.624e-214 676.0
DTH2_k127_9626654_1 TIGRFAM Diguanylate cyclase K13590 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 425.0
DTH2_k127_9626654_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 373.0
DTH2_k127_9626654_3 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 374.0
DTH2_k127_9626654_4 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009579 296.0
DTH2_k127_9675493_0 response regulator K10943 - - 7.537e-214 674.0
DTH2_k127_9675493_1 Signal transduction histidine kinase K10942 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009423 533.0
DTH2_k127_9689872_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0 1017.0
DTH2_k127_9689872_1 Glutamate-cysteine ligase K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000007873 216.0
DTH2_k127_9690148_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1432.0
DTH2_k127_9690148_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 461.0
DTH2_k127_9763976_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 601.0
DTH2_k127_9763976_1 Putative MetA-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 491.0
DTH2_k127_9763976_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003496 255.0
DTH2_k127_9765710_0 PFAM chemotaxis K02660 - - 6.344e-220 690.0
DTH2_k127_9787159_0 NAD(P)H-binding K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007238 492.0
DTH2_k127_9787159_1 MlaA lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 316.0
DTH2_k127_9787159_2 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 306.0
DTH2_k127_9791358_0 HI0933-like protein K07007 - - 3.45e-197 621.0
DTH2_k127_9791358_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 312.0
DTH2_k127_9791358_2 Protein of unknown function (DUF2909) - - - 0.00000000000000000002906 93.0
DTH2_k127_9853872_0 Heavy metal transport detoxification protein K17686,K19597 - 3.6.3.54 1.755e-273 847.0
DTH2_k127_9853872_1 SMART ATPase, AAA type, core K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 591.0
DTH2_k127_9853872_2 PFAM Heavy metal transport detoxification protein K07213 - - 0.000000000000000001378 89.0
DTH2_k127_99135_0 Putative Na+/H+ antiporter - - - 5.001e-223 696.0
DTH2_k127_99135_1 Periplasmic 7TM domain sensor diguanylate cyclase - - - 3.006e-202 645.0
DTH2_k127_99135_2 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 320.0
DTH2_k127_99135_3 Sodium/calcium exchanger protein K07301 - - 0.00000000000000931 74.0
DTH2_k127_9944137_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 1.866e-242 754.0
DTH2_k127_9944137_1 TIGRFAM type I secretion outer membrane protein, TolC K12340 - - 2.153e-207 653.0
DTH2_k127_9944137_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 428.0
DTH2_k127_9944137_3 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 385.0
DTH2_k127_9944137_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000005278 231.0
DTH2_k127_9944137_5 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000003825 136.0
DTH2_k127_9944137_7 - - - - 0.00001041 48.0