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Overview

ID MAG00807
Name DTH3_bin.27
Sample SMP0024
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus Methanothrix
Species
Assembly information
Completeness (%) 64.96
Contamination (%) 1.24
GC content (%) 56.0
N50 (bp) 2,723
Genome size (bp) 834,225

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes942

Gene name Description KEGG GOs EC E-value Score Sequence
DTH3_k127_1017631_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001122 249.0
DTH3_k127_1017631_1 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000005251 216.0
DTH3_k127_1017631_2 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.0002344 52.0
DTH3_k127_1044839_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 477.0
DTH3_k127_1044839_1 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000003597 162.0
DTH3_k127_1048220_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 437.0
DTH3_k127_1048220_1 PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000003372 108.0
DTH3_k127_1112075_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 9.8e-269 841.0
DTH3_k127_1112075_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 564.0
DTH3_k127_1112075_2 DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009797 256.0
DTH3_k127_1112075_3 low-complexity proteins - - - 0.00000000000000000000000000000000000002207 164.0
DTH3_k127_1112075_4 PFAM PKD domain containing protein - - - 0.000005466 51.0
DTH3_k127_131083_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 515.0
DTH3_k127_131083_1 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000005427 185.0
DTH3_k127_131083_2 Related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 6.1.1.7 0.00000000000000000000000000000001015 131.0
DTH3_k127_131083_3 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000004357 121.0
DTH3_k127_131083_4 protein conserved in archaea - - - 0.000000000000000000000000001763 115.0
DTH3_k127_131083_5 PFAM Threonyl alanyl tRNA synthetase, SAD K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000841 107.0
DTH3_k127_131083_6 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000003845 56.0
DTH3_k127_131663_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 387.0
DTH3_k127_131663_1 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.000000000000000000000000000000000000000000000000000000000000000004553 237.0
DTH3_k127_131663_2 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000436 167.0
DTH3_k127_131663_3 - - - - 0.0000000000335 73.0
DTH3_k127_1436636_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 449.0
DTH3_k127_1567213_0 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 331.0
DTH3_k127_1567213_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000007594 121.0
DTH3_k127_1567213_2 Lrp/AsnC ligand binding domain - - - 0.000000000007499 69.0
DTH3_k127_1571027_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 355.0
DTH3_k127_1571027_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001003 285.0
DTH3_k127_1571027_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000002235 73.0
DTH3_k127_1579588_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 3.813e-204 643.0
DTH3_k127_1579588_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 374.0
DTH3_k127_1579588_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000005007 211.0
DTH3_k127_1611276_0 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000000000000000000000000000000000000000000000000003293 231.0
DTH3_k127_1611276_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000006518 213.0
DTH3_k127_1611276_2 PFAM Fic DOC family - - - 0.0000000000000000000000101 104.0
DTH3_k127_1611276_3 PFAM Fic DOC family - - - 0.00000001132 65.0
DTH3_k127_1685249_0 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 293.0
DTH3_k127_1685249_1 - - - - 0.00000000000000000000000000000000001301 141.0
DTH3_k127_1685249_2 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000000001573 113.0
DTH3_k127_1685249_3 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000001888 50.0
DTH3_k127_1722186_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1128.0
DTH3_k127_1722186_1 - - - - 0.00000000001485 65.0
DTH3_k127_1722186_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000011 59.0
DTH3_k127_1722367_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 415.0
DTH3_k127_1722367_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000001428 265.0
DTH3_k127_1725068_0 Biotin-lipoyl like K01993,K16922 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 413.0
DTH3_k127_1725068_1 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000002585 199.0
DTH3_k127_1740471_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 587.0
DTH3_k127_1740471_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000006274 186.0
DTH3_k127_1740471_2 PFAM ribosomal protein S8E K02995 GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.00000000000000000000000000000000000000008794 154.0
DTH3_k127_1740471_3 Calcineurin-like phosphoesterase - - - 0.000000004579 67.0
DTH3_k127_1740471_4 Domain of unknown function (DUF1922) - - - 0.000005548 51.0
DTH3_k127_176525_0 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 490.0
DTH3_k127_176525_1 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction K08482 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531 - 0.00007279 50.0
DTH3_k127_1786540_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 533.0
DTH3_k127_1786540_1 synthase subunit 1 K01648 GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006091,GO:0006101,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 381.0
DTH3_k127_1786540_2 C-terminal region of MMR_HSR1 domain K06944 - - 0.00000000000000000000000000000000000000000000000001398 182.0
DTH3_k127_1786540_3 metal-dependent phosphoesterases (PHP family) - - - 0.00000000000000000000000000000000000000000000001862 179.0
DTH3_k127_1790248_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 388.0
DTH3_k127_1790248_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 351.0
DTH3_k127_1790248_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000001871 89.0
DTH3_k127_1790248_11 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000000000236 89.0
DTH3_k127_1790248_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000001465 78.0
DTH3_k127_1790248_2 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 330.0
DTH3_k127_1790248_3 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 291.0
DTH3_k127_1790248_4 Putative RNA methyltransferase K09142 - - 0.0000000000000000000000000000000000000000000000000000000000000001338 232.0
DTH3_k127_1790248_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000002105 173.0
DTH3_k127_1790248_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000356 165.0
DTH3_k127_1790248_7 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000000001209 159.0
DTH3_k127_1790248_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000007258 121.0
DTH3_k127_1790248_9 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000001166 102.0
DTH3_k127_1843328_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.538e-232 732.0
DTH3_k127_1843328_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 285.0
DTH3_k127_1843328_2 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000001149 148.0
DTH3_k127_1935111_0 phosphorelay sensor kinase activity K01768 - 4.6.1.1 4.991e-223 699.0
DTH3_k127_1935111_1 PFAM 4-vinyl reductase, 4VR K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000707 325.0
DTH3_k127_1947849_0 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000002991 241.0
DTH3_k127_1947849_1 MoaE protein K03635 - 2.8.1.12 0.000000000002988 70.0
DTH3_k127_2012547_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 454.0
DTH3_k127_2012547_1 Belongs to the acylphosphatase family - - - 0.000000000000000000000000000000000004018 143.0
DTH3_k127_2015802_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 450.0
DTH3_k127_2015802_1 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000004114 119.0
DTH3_k127_2111113_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 348.0
DTH3_k127_2111113_1 - - - - 0.0000000000001772 76.0
DTH3_k127_2111113_2 - - - - 0.0000000000008244 69.0
DTH3_k127_2111113_3 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000145 64.0
DTH3_k127_2149599_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 419.0
DTH3_k127_2149599_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 356.0
DTH3_k127_2149599_3 Protein of unknown function DUF86 - - - 0.00000000000000000000005294 108.0
DTH3_k127_2149599_4 DNA polymerase beta domain protein region K07076 - - 0.0000000000000001901 86.0
DTH3_k127_2149714_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 550.0
DTH3_k127_2149714_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000002992 203.0
DTH3_k127_2149714_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0004217 42.0
DTH3_k127_221988_0 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000142 61.0
DTH3_k127_221988_1 Zn-ribbon protein possibly nucleic acid-binding - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000006712 57.0
DTH3_k127_221988_2 Protein of unknown function (DUF541) K09807 - - 0.00007574 48.0
DTH3_k127_2279541_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.00000000000000000001521 96.0
DTH3_k127_2297110_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 347.0
DTH3_k127_2297110_1 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008311 276.0
DTH3_k127_2297110_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000002364 256.0
DTH3_k127_2297110_3 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00004955 49.0
DTH3_k127_234033_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 574.0
DTH3_k127_234033_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000977 280.0
DTH3_k127_234033_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000008209 224.0
DTH3_k127_2451641_0 Isocitrate/isopropylmalate dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 578.0
DTH3_k127_2451641_1 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001317 258.0
DTH3_k127_2451641_2 Nucleotidyl transferase K00966 GO:0000032,GO:0003674,GO:0003824,GO:0004475,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008905,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009272,GO:0009298,GO:0009653,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019673,GO:0030154,GO:0030435,GO:0031506,GO:0032502,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0043934,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0048646,GO:0048856,GO:0048869,GO:0051286,GO:0055086,GO:0070085,GO:0070568,GO:0070589,GO:0070590,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.13 0.00003922 47.0
DTH3_k127_2464812_0 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000001936 232.0
DTH3_k127_2464812_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000004288 188.0
DTH3_k127_248605_0 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002517 278.0
DTH3_k127_248605_1 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000004772 198.0
DTH3_k127_248605_2 Activator of Hsp90 ATPase - - - 0.0000000001699 62.0
DTH3_k127_248605_3 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.000000003827 59.0
DTH3_k127_248605_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K14392 - - 0.0000398 49.0
DTH3_k127_250709_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 382.0
DTH3_k127_250709_1 PFAM PP-loop domain protein - - - 0.00000000001548 65.0
DTH3_k127_2519642_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1125.0
DTH3_k127_2522590_0 Aminotransferase class-III K00823,K00836 - 2.6.1.19,2.6.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 366.0
DTH3_k127_2522590_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 299.0
DTH3_k127_2522590_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 297.0
DTH3_k127_2605935_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 360.0
DTH3_k127_2605935_1 nucleotidyltransferase activity K07076 - - 0.000000000000000001427 96.0
DTH3_k127_2617768_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 442.0
DTH3_k127_2617768_1 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000001093 190.0
DTH3_k127_2617768_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000003361 124.0
DTH3_k127_2637772_0 cellular potassium ion transport K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 360.0
DTH3_k127_2637772_1 PFAM Cation K03498 - - 0.00000000000000000007564 96.0
DTH3_k127_2637772_2 COG0168 Trk-type K transport systems, membrane components K03498 - - 0.00007439 46.0
DTH3_k127_2656748_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 552.0
DTH3_k127_2656748_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000003884 257.0
DTH3_k127_2656748_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.000000000000000000000000000000000000000000000000000000000000000000418 230.0
DTH3_k127_265825_0 Threonine synthase N terminus K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 537.0
DTH3_k127_265825_1 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 301.0
DTH3_k127_265825_2 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000002166 159.0
DTH3_k127_267501_0 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 317.0
DTH3_k127_267501_1 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 300.0
DTH3_k127_267501_2 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000003773 219.0
DTH3_k127_267501_3 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000004997 158.0
DTH3_k127_267501_4 Universal stress protein family - - - 0.0000000000000000000000000000000001832 136.0
DTH3_k127_267501_5 Universal stress protein family - - - 0.0000000000000000000000000001217 120.0
DTH3_k127_267501_6 COG1525 Micrococcal nuclease (thermonuclease) homologs K01174 - 3.1.31.1 0.00000000000000000000003312 104.0
DTH3_k127_2699974_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 448.0
DTH3_k127_2699974_1 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 376.0
DTH3_k127_2699974_2 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 315.0
DTH3_k127_2699974_3 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000003539 194.0
DTH3_k127_2734886_0 Metallo-beta-lactamase superfamily K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 321.0
DTH3_k127_2734886_1 SMART Elongator protein 3 MiaB NifB K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 297.0
DTH3_k127_2734886_2 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000001932 201.0
DTH3_k127_2734886_3 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000004007 158.0
DTH3_k127_2734886_4 PFAM Thioredoxin K03671 - - 0.00000000000000000000005389 100.0
DTH3_k127_2735853_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003471 286.0
DTH3_k127_2735853_1 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.000000000000000003588 85.0
DTH3_k127_2790112_0 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 488.0
DTH3_k127_2790112_1 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000304 281.0
DTH3_k127_2790112_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000003818 113.0
DTH3_k127_2831335_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 378.0
DTH3_k127_2831335_1 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007038 276.0
DTH3_k127_2831335_2 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.000000000000000000000000000000000000000000000000001888 184.0
DTH3_k127_2853452_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 292.0
DTH3_k127_2853452_1 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000008451 125.0
DTH3_k127_2853452_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K12143,K15831 - - 0.0000000005308 65.0
DTH3_k127_2913014_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 565.0
DTH3_k127_293980_0 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000004699 173.0
DTH3_k127_293980_1 Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000008925 158.0
DTH3_k127_293980_2 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000001484 143.0
DTH3_k127_293980_3 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000003716 138.0
DTH3_k127_293980_4 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.0000000000000000000000000003984 121.0
DTH3_k127_293980_5 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000003282 57.0
DTH3_k127_2969592_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 5.543e-230 722.0
DTH3_k127_2969592_1 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 316.0
DTH3_k127_3018669_0 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 584.0
DTH3_k127_3018669_1 Methyl-coenzyme M reductase operon protein D K03422 - - 0.000000000000000000000000000000000008768 142.0
DTH3_k127_3023234_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000000000000000000000000000000000001275 238.0
DTH3_k127_3023234_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000287 168.0
DTH3_k127_3023234_2 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000004453 119.0
DTH3_k127_3023234_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000002071 114.0
DTH3_k127_3028479_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 306.0
DTH3_k127_3028479_1 Domain of unknown function (DUF1947) K07575 - - 0.0000000000000000000000000000000000000001469 156.0
DTH3_k127_3028479_2 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000000001947 113.0
DTH3_k127_3028479_3 binds to the 23S rRNA K02922 - - 0.000000000000001224 77.0
DTH3_k127_3028479_4 Stage II sporulation protein M - - - 0.00000072 56.0
DTH3_k127_3035219_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000001071 228.0
DTH3_k127_3035219_1 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001128 205.0
DTH3_k127_3035219_2 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.000000000000000000000001798 103.0
DTH3_k127_3035219_3 PFAM PRC-barrel domain - - - 0.00000000000000000009783 91.0
DTH3_k127_3035219_4 - - - - 0.0000000000007805 79.0
DTH3_k127_3036750_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 380.0
DTH3_k127_3036750_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 311.0
DTH3_k127_3036750_2 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000073 277.0
DTH3_k127_308434_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 330.0
DTH3_k127_308434_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000001507 151.0
DTH3_k127_3111212_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001294 276.0
DTH3_k127_3111212_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000002415 184.0
DTH3_k127_3111212_2 phosphorelay signal transduction system - - - 0.0000000000000003914 83.0
DTH3_k127_3111212_3 PFAM membrane-bound metal-dependent hydrolase K07038 - - 0.000000003025 66.0
DTH3_k127_3111212_4 Transcriptional regulator - - - 0.0003847 46.0
DTH3_k127_3146197_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 465.0
DTH3_k127_3146197_1 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000003685 64.0
DTH3_k127_3170205_0 photosystem II stabilization - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 426.0
DTH3_k127_3170205_1 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000003415 158.0
DTH3_k127_3183968_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1140.0
DTH3_k127_3224336_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 9.901e-229 721.0
DTH3_k127_3276585_0 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 338.0
DTH3_k127_3276585_1 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000616 171.0
DTH3_k127_3276585_2 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000000000004707 117.0
DTH3_k127_3276585_3 archaeal coiled-coil protein - - - 0.00002196 47.0
DTH3_k127_328227_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.105e-197 630.0
DTH3_k127_328227_1 Integral membrane protein DUF106 - - - 0.0000000000000000000000000000000000000000000000000001225 193.0
DTH3_k127_328227_2 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000001453 174.0
DTH3_k127_328227_3 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000003982 149.0
DTH3_k127_328227_4 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000001544 136.0
DTH3_k127_328227_5 binds to the 23S rRNA K02876 - - 0.000000000000000000001118 98.0
DTH3_k127_328227_6 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 - 0.000000000000001567 81.0
DTH3_k127_3379110_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 353.0
DTH3_k127_3379110_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 342.0
DTH3_k127_3381813_0 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 292.0
DTH3_k127_3381813_1 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001831 262.0
DTH3_k127_3410385_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000003655 280.0
DTH3_k127_3410385_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000003781 203.0
DTH3_k127_3411779_0 4Fe-4S dicluster domain K00196 - - 0.00000000000000000000000000000000000000000000000001866 184.0
DTH3_k127_3411779_1 PFAM GvpD gas vesicle - - - 0.00000000000000000000000000000000000000000000000007054 195.0
DTH3_k127_3411779_2 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 0.00000000001265 64.0
DTH3_k127_3411779_3 Pas domain - - - 0.0001752 49.0
DTH3_k127_3413780_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007563 285.0
DTH3_k127_3413780_1 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000001316 191.0
DTH3_k127_3413780_2 Putative zinc- or iron-chelating domain K06940 - - 0.00000003857 64.0
DTH3_k127_3422121_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.00000000000000000000000000000000000004592 154.0
DTH3_k127_3422121_1 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000001176 61.0
DTH3_k127_3422121_2 peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0001352 52.0
DTH3_k127_3428199_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 585.0
DTH3_k127_3428199_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000002857 212.0
DTH3_k127_3428199_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000002379 200.0
DTH3_k127_3428199_3 - - - - 0.00000000019 62.0
DTH3_k127_346064_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 415.0
DTH3_k127_346064_1 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 364.0
DTH3_k127_346064_2 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000001129 216.0
DTH3_k127_347962_0 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 298.0
DTH3_k127_347962_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000004501 71.0
DTH3_k127_347962_2 peptidyl-tyrosine sulfation - - - 0.0006108 48.0
DTH3_k127_3551936_0 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000000000000363 235.0
DTH3_k127_3551936_1 protein histidine kinase activity K03320 - - 0.000000000000000000000000000000000007249 140.0
DTH3_k127_3551936_2 COG1201 Lhr-like helicases K03724 - - 0.0000001587 55.0
DTH3_k127_3559659_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 426.0
DTH3_k127_3559659_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004436 274.0
DTH3_k127_3559659_2 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000000000000000000000000000000000000000000000000001816 233.0
DTH3_k127_3560454_0 CoA binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 456.0
DTH3_k127_3560454_1 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005385 267.0
DTH3_k127_3560454_2 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000000002095 104.0
DTH3_k127_3593325_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 297.0
DTH3_k127_3593325_1 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.000000000000000000000000000000000000000000115 165.0
DTH3_k127_3593325_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000001626 89.0
DTH3_k127_3617238_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 425.0
DTH3_k127_3617238_1 NYN domain - - - 0.0000000000000000000000000000000000000000000000000001017 191.0
DTH3_k127_3648414_0 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 594.0
DTH3_k127_3648414_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000001502 134.0
DTH3_k127_3648414_2 Predicted RNA-binding protein K06964 - - 0.0000009819 52.0
DTH3_k127_3655396_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 377.0
DTH3_k127_3655396_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000006331 232.0
DTH3_k127_3673421_0 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000008943 167.0
DTH3_k127_3683629_0 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 395.0
DTH3_k127_3683629_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000004294 59.0
DTH3_k127_3683629_2 protein conserved in archaea K09746 - - 0.0005311 42.0
DTH3_k127_3688826_0 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000921 372.0
DTH3_k127_3688826_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 310.0
DTH3_k127_3688826_2 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 291.0
DTH3_k127_3688826_3 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002276 270.0
DTH3_k127_3688826_4 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000000000000000000658 130.0
DTH3_k127_3691285_0 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 4.253e-235 735.0
DTH3_k127_3691285_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 5.404e-212 666.0
DTH3_k127_3691285_2 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 608.0
DTH3_k127_3691285_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000004102 106.0
DTH3_k127_3691285_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000009109 93.0
DTH3_k127_3717426_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 423.0
DTH3_k127_372425_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.512e-241 774.0
DTH3_k127_372425_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006826 265.0
DTH3_k127_3769754_0 Protein of unknown function (DUF1616) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 297.0
DTH3_k127_3769754_1 - - - - 0.000000000000000003476 94.0
DTH3_k127_387304_0 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000003622 239.0
DTH3_k127_387304_1 PFAM PilT protein domain protein K06865 - - 0.0000000000000000000000000000000000000007271 150.0
DTH3_k127_387304_2 4Fe-4S binding domain - - - 0.0000000000000000000000000003997 115.0
DTH3_k127_3896852_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 582.0
DTH3_k127_3896852_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 299.0
DTH3_k127_3896852_2 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 296.0
DTH3_k127_3896852_3 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000003289 154.0
DTH3_k127_3925503_0 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000301 269.0
DTH3_k127_3925503_1 ABC-type transport system involved in Fe-S cluster assembly, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000002282 216.0
DTH3_k127_3925503_2 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000001787 102.0
DTH3_k127_3925503_3 - - - - 0.00000000000001531 74.0
DTH3_k127_3925503_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000005226 60.0
DTH3_k127_3932445_0 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000008564 231.0
DTH3_k127_3932445_1 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000549 230.0
DTH3_k127_3948651_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 293.0
DTH3_k127_3948651_1 ADP-specific Phosphofructokinase/Glucokinase conserved region K00918 - 2.7.1.146,2.7.1.147 0.000000000000000000000000003313 118.0
DTH3_k127_4058725_0 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 443.0
DTH3_k127_4058725_1 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000002672 147.0
DTH3_k127_4058725_2 Protein of unknown function (DUF1614) - - - 0.000000000000000000000000002802 115.0
DTH3_k127_4060172_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007918 450.0
DTH3_k127_4069458_0 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000000000000000000000000000000000004146 225.0
DTH3_k127_4069458_1 Na -dependent transporter K03453 - - 0.00000000000000000000000000000000000000000000000005169 189.0
DTH3_k127_4080708_0 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 403.0
DTH3_k127_4080708_1 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000003215 209.0
DTH3_k127_4080708_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000874 196.0
DTH3_k127_4080708_3 Secreted repeat of unknown function - - - 0.000000000000000000000000001115 118.0
DTH3_k127_4080708_4 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000008507 51.0
DTH3_k127_4131826_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 291.0
DTH3_k127_4131826_1 Tex-like protein N-terminal domain K06959 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001166 261.0
DTH3_k127_4131826_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000008651 177.0
DTH3_k127_4182836_0 permease K03299 - - 0.0000000000000000000000000000000000000000000000000000000000006103 226.0
DTH3_k127_4182836_1 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000007544 139.0
DTH3_k127_4213999_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 459.0
DTH3_k127_4446652_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004962 269.0
DTH3_k127_4446652_1 Carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000117 189.0
DTH3_k127_4446652_2 Contacts the emerging nascent chain on the ribosome K03626 - - 0.00000000000000000000000008827 111.0
DTH3_k127_445746_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 497.0
DTH3_k127_445746_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 428.0
DTH3_k127_445746_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000006233 177.0
DTH3_k127_4457497_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000000000000000000000000000000000000000004266 204.0
DTH3_k127_4457497_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000000000000000000000000007203 127.0
DTH3_k127_4457497_2 RNA binding K07581 - - 0.000000000000000000000004222 106.0
DTH3_k127_4457497_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000636 108.0
DTH3_k127_4495996_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 3.398e-233 736.0
DTH3_k127_4495996_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 373.0
DTH3_k127_4510254_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000004269 226.0
DTH3_k127_4510254_1 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000001278 146.0
DTH3_k127_4510254_2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000001316 118.0
DTH3_k127_4510254_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000005323 116.0
DTH3_k127_4510254_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.0000000000000003033 82.0
DTH3_k127_4510254_5 - - - - 0.00000000007309 68.0
DTH3_k127_4517679_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.592e-194 615.0
DTH3_k127_4517679_1 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000001964 192.0
DTH3_k127_4517679_2 transcriptional regulator, SARP family - - - 0.0000000002316 73.0
DTH3_k127_4522416_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 1.098e-301 935.0
DTH3_k127_4522416_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000001905 245.0
DTH3_k127_4538690_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.88e-244 767.0
DTH3_k127_4538690_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 0.000000000000000000000000000000000000000000000000007235 182.0
DTH3_k127_4539719_0 Serine hydroxymethyltransferase K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005879 542.0
DTH3_k127_4539719_1 PFAM PUA domain containing protein K07398 - - 0.000000000000000000000000000000000000000001838 160.0
DTH3_k127_4539719_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000006001 75.0
DTH3_k127_458149_0 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 453.0
DTH3_k127_458149_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000001446 156.0
DTH3_k127_458149_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000001246 60.0
DTH3_k127_4602356_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 421.0
DTH3_k127_4649447_0 TIGRFAM Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000131 225.0
DTH3_k127_4649447_1 Histone deacetylase domain - - - 0.00000000000000000000000000001635 121.0
DTH3_k127_4649447_2 PFAM formate nitrite transporter K21993 - - 0.00000001937 55.0
DTH3_k127_4679310_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.485e-238 747.0
DTH3_k127_4679310_1 Sodium:solute symporter family K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 462.0
DTH3_k127_4679310_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 380.0
DTH3_k127_4679310_3 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 308.0
DTH3_k127_4679310_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000003384 147.0
DTH3_k127_4740747_0 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 366.0
DTH3_k127_4740747_1 - - - - 0.00000000916 63.0
DTH3_k127_4762125_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008051 359.0
DTH3_k127_4762125_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001757 285.0
DTH3_k127_4762125_2 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000004711 164.0
DTH3_k127_4781492_0 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001495 262.0
DTH3_k127_4781492_1 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000005852 228.0
DTH3_k127_4781492_2 Domain of unknown function (DUF2088) - - - 0.000000000000000000003681 98.0
DTH3_k127_4802171_0 Glycogen synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 376.0
DTH3_k127_4802171_1 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000001396 152.0
DTH3_k127_48333_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001592 275.0
DTH3_k127_48333_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000001653 154.0
DTH3_k127_4840449_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001258 224.0
DTH3_k127_4840449_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000001001 176.0
DTH3_k127_4840449_2 Archaeal Nre, N-terminal - - - 0.0000000000000000004133 91.0
DTH3_k127_4845326_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005284 277.0
DTH3_k127_4845326_1 Fumarase C-terminus K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000000009522 185.0
DTH3_k127_4845326_2 Protein of unknown function (DUF434) - - - 0.000000000000000000000000008933 115.0
DTH3_k127_4845326_3 Domain of unknown function - - - 0.0000000000000000000000001871 109.0
DTH3_k127_4870324_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 3.304e-220 692.0
DTH3_k127_4870324_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000003651 251.0
DTH3_k127_4983407_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 6.243e-199 631.0
DTH3_k127_4983407_1 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 337.0
DTH3_k127_4983407_2 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000001109 203.0
DTH3_k127_4992015_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 452.0
DTH3_k127_4995410_0 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 307.0
DTH3_k127_4995410_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000155 246.0
DTH3_k127_4995410_2 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000000000000000000000000004817 145.0
DTH3_k127_4995410_3 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.0000000000000000000137 93.0
DTH3_k127_4997117_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 361.0
DTH3_k127_4997117_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005803 297.0
DTH3_k127_4997117_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001786 267.0
DTH3_k127_4997117_3 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001494 244.0
DTH3_k127_4997117_4 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000007339 218.0
DTH3_k127_4997117_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000006941 202.0
DTH3_k127_4997117_6 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000001013 125.0
DTH3_k127_4997117_7 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000003507 126.0
DTH3_k127_4997117_8 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000001064 104.0
DTH3_k127_5017327_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 419.0
DTH3_k127_5017327_1 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000005296 190.0
DTH3_k127_5017327_2 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000000000000000000002939 192.0
DTH3_k127_5017327_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000003189 127.0
DTH3_k127_5017327_4 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000001935 118.0
DTH3_k127_50201_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 292.0
DTH3_k127_50201_1 - - - - 0.0000000271 60.0
DTH3_k127_5044674_0 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 355.0
DTH3_k127_5044674_1 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 291.0
DTH3_k127_5044674_2 Integrase core domain - - - 0.000611 46.0
DTH3_k127_5045029_0 AAA family ATPase, CDC48 subfamily K13525 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 480.0
DTH3_k127_5045029_1 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000001528 130.0
DTH3_k127_5106097_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 540.0
DTH3_k127_5134690_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 400.0
DTH3_k127_5140813_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000248 261.0
DTH3_k127_5140813_1 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000004347 164.0
DTH3_k127_5140813_2 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000001642 75.0
DTH3_k127_51430_0 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 296.0
DTH3_k127_51430_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000001452 204.0
DTH3_k127_5145454_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000002881 203.0
DTH3_k127_5145454_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000005172 131.0
DTH3_k127_5145454_2 methyltransferase - - - 0.0000000000000009027 87.0
DTH3_k127_5180959_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 386.0
DTH3_k127_5180959_1 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006625 281.0
DTH3_k127_5180959_2 Belongs to the UPF0284 family - - - 0.00000948 50.0
DTH3_k127_5192402_0 Peptidase S9 prolyl oligopeptidase active site K01278,K01322 - 3.4.14.5,3.4.21.26 1.001e-224 716.0
DTH3_k127_5214858_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 559.0
DTH3_k127_5214858_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000008277 220.0
DTH3_k127_5252212_0 Involved in cell shape control K22222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 407.0
DTH3_k127_526723_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 5e-324 1008.0
DTH3_k127_529161_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 1.962e-281 876.0
DTH3_k127_529161_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00186 - 1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 318.0
DTH3_k127_529161_2 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000123 240.0
DTH3_k127_5301036_0 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.000000000000000000000000000000000000000000000000000000000005819 215.0
DTH3_k127_5301036_1 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000001873 145.0
DTH3_k127_5301036_2 - - - - 0.000000000000002827 81.0
DTH3_k127_5334104_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 483.0
DTH3_k127_5334104_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000004753 227.0
DTH3_k127_5334104_2 PFAM DsrE family protein K07092 GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.0000000000000000000000000000000000000000000000003023 178.0
DTH3_k127_5334104_3 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000001883 117.0
DTH3_k127_5451066_0 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 494.0
DTH3_k127_5451066_1 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000003418 196.0
DTH3_k127_5451066_2 PFAM coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00441 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016725,GO:0052592,GO:0055114 1.12.98.1 0.0000000000000000000000000000000005018 137.0
DTH3_k127_5453443_0 Tex-like protein N-terminal domain K06959 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 540.0
DTH3_k127_5453443_1 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 372.0
DTH3_k127_5453443_2 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000009395 75.0
DTH3_k127_5474895_0 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 354.0
DTH3_k127_5477197_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 304.0
DTH3_k127_5477197_1 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006127 264.0
DTH3_k127_5477197_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000008938 211.0
DTH3_k127_5477197_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000003209 207.0
DTH3_k127_5477197_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000005476 200.0
DTH3_k127_5477197_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000004654 186.0
DTH3_k127_5477197_6 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000001786 172.0
DTH3_k127_5477197_7 Belongs to the eukaryotic ribosomal protein eL32 family K02912 - - 0.00000000000000000000000000001693 122.0
DTH3_k127_5477197_8 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000001263 91.0
DTH3_k127_5477197_9 TIGRFAM ribosomal protein L30P K02907 - - 0.00005155 48.0
DTH3_k127_5512479_0 Domain of unknown function (DUF814) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005849 494.0
DTH3_k127_5512479_1 CHAT domain - - - 0.00000000000000000000000000000000000003154 152.0
DTH3_k127_5512479_2 Belongs to the peptidase S8 family K01400,K01417,K20274 - 3.4.24.28 0.00000000001482 66.0
DTH3_k127_5512479_3 Mut7-C RNAse domain K09122 - - 0.0000000000752 68.0
DTH3_k127_5512479_4 Mut7-C RNAse domain K09122 - - 0.000007952 49.0
DTH3_k127_5518586_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 492.0
DTH3_k127_5518586_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K13531 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000000000000000000007046 201.0
DTH3_k127_5539863_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000335 285.0
DTH3_k127_5539863_1 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000001237 243.0
DTH3_k127_5539863_2 methyltransferase activity K21310 - 2.1.1.334 0.0000000000000000002532 91.0
DTH3_k127_554174_0 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 290.0
DTH3_k127_554174_1 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.00000000000000000000000000000000532 130.0
DTH3_k127_554174_2 Protein of unknown function DUF86 - - - 0.00000000000000000003913 91.0
DTH3_k127_554174_3 Protein of unknown function DUF86 - - - 0.000000001681 59.0
DTH3_k127_5543691_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 375.0
DTH3_k127_5543691_1 Belongs to the TCP-1 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.0000000000000000000000000000000000000000000000000000000000000000000000002278 254.0
DTH3_k127_5543691_2 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000001895 201.0
DTH3_k127_5543691_3 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000008516 177.0
DTH3_k127_5543691_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000047 123.0
DTH3_k127_5555994_0 AAA family ATPase, CDC48 subfamily K13525 - - 6.611e-209 659.0
DTH3_k127_5555994_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 286.0
DTH3_k127_568276_0 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 385.0
DTH3_k127_568276_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000006377 122.0
DTH3_k127_5688180_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 428.0
DTH3_k127_5688180_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006846 269.0
DTH3_k127_5688180_2 Acylphosphatase K01512 - 3.6.1.7 0.0000000001858 67.0
DTH3_k127_5733978_0 methyltransferase - - - 0.00000000000000000000000000000000000000000000000001428 188.0
DTH3_k127_5733978_1 Proline dehydrogenase K00318 - - 0.000000000000000000008639 101.0
DTH3_k127_5738489_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 5.523e-203 641.0
DTH3_k127_5739241_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 456.0
DTH3_k127_5739241_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 331.0
DTH3_k127_5739241_2 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 295.0
DTH3_k127_5739241_3 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000008798 109.0
DTH3_k127_5742801_0 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007859 246.0
DTH3_k127_5767834_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 554.0
DTH3_k127_5767834_1 PFAM Bacterial transferase hexapeptide (three repeats) K13018 - 2.3.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009959 272.0
DTH3_k127_5767834_2 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000000000000000000007271 150.0
DTH3_k127_5776104_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 407.0
DTH3_k127_5776104_1 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000001422 186.0
DTH3_k127_5776104_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000007671 126.0
DTH3_k127_5784316_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000006331 223.0
DTH3_k127_5791304_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 5.869e-195 621.0
DTH3_k127_5813493_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000007195 256.0
DTH3_k127_5813493_1 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000007529 169.0
DTH3_k127_5813493_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000008044 154.0
DTH3_k127_5838203_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000003692 97.0
DTH3_k127_5838203_1 Major Facilitator K08151,K08153 - - 0.0007687 49.0
DTH3_k127_5844544_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 488.0
DTH3_k127_5844544_1 PINc domain ribonuclease K09006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003685 271.0
DTH3_k127_5860856_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007759 538.0
DTH3_k127_5860856_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 451.0
DTH3_k127_5860856_2 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000004397 220.0
DTH3_k127_5877732_0 PFAM Class II Aldolase K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000001547 175.0
DTH3_k127_5877732_1 Serine protease with a broad substrate specificity K17734 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005509,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000009342 143.0
DTH3_k127_587991_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000001379 203.0
DTH3_k127_587991_1 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000001297 110.0
DTH3_k127_5900040_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 383.0
DTH3_k127_5900040_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000101 182.0
DTH3_k127_5900040_2 membrane - - - 0.000000000000000000000000000000003443 138.0
DTH3_k127_5900040_3 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000002957 118.0
DTH3_k127_5947997_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 6.149e-203 645.0
DTH3_k127_5947997_1 TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008091 381.0
DTH3_k127_5952075_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 474.0
DTH3_k127_5952075_1 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 401.0
DTH3_k127_5952075_2 GXGXG motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 306.0
DTH3_k127_5966044_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 305.0
DTH3_k127_5966044_1 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000006601 144.0
DTH3_k127_5992872_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 548.0
DTH3_k127_5992872_1 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 327.0
DTH3_k127_5997268_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1120.0
DTH3_k127_6001264_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009766 386.0
DTH3_k127_6001264_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 304.0
DTH3_k127_6001264_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000034 116.0
DTH3_k127_6062993_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 2.712e-204 645.0
DTH3_k127_6062993_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 472.0
DTH3_k127_6062993_2 acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000001384 117.0
DTH3_k127_6064956_0 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 476.0
DTH3_k127_6064956_1 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane K08265 GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0031224,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0044425,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.00000000000000000000000000000000000000001216 162.0
DTH3_k127_6073512_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000003602 237.0
DTH3_k127_6073512_1 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001215 234.0
DTH3_k127_6073512_2 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000001254 160.0
DTH3_k127_6073512_3 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000000282 84.0
DTH3_k127_6073512_4 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000001204 82.0
DTH3_k127_6079244_0 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000003081 231.0
DTH3_k127_6079244_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000002837 213.0
DTH3_k127_6079244_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000001408 181.0
DTH3_k127_6079244_3 - - - - 0.000000000000000000000000000000000001052 146.0
DTH3_k127_6079244_4 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases - - - 0.000000000000000007379 89.0
DTH3_k127_6084663_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003423 280.0
DTH3_k127_6084663_1 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000006789 87.0
DTH3_k127_6084663_2 Methyltransferase type 11 - - - 0.00000000000008041 72.0
DTH3_k127_6144191_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 301.0
DTH3_k127_6144191_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 292.0
DTH3_k127_6144191_2 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000000000000000001555 188.0
DTH3_k127_6144901_0 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 384.0
DTH3_k127_6144901_1 Belongs to the UPF0248 family K09715 - - 0.00000000000000000001024 94.0
DTH3_k127_6144901_2 adenylylsulfate kinase activity K00860 - 2.7.1.25 0.00000000000001092 77.0
DTH3_k127_6144901_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000001977 82.0
DTH3_k127_6220194_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000009574 189.0
DTH3_k127_6220194_1 Tetratricopeptide repeat - - - 0.000000001082 70.0
DTH3_k127_6296661_0 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 462.0
DTH3_k127_6296661_1 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001576 260.0
DTH3_k127_6296661_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000001403 249.0
DTH3_k127_6296661_3 extracellular matrix structural constituent - - - 0.00000000000000000000000000002598 128.0
DTH3_k127_6306016_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 353.0
DTH3_k127_6306016_1 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 304.0
DTH3_k127_6306016_2 Carboxypeptidase regulatory-like domain - - - 0.0008026 49.0
DTH3_k127_6317414_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299 - 1.17.1.10,1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 479.0
DTH3_k127_6342954_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003528 285.0
DTH3_k127_6342954_1 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002814 252.0
DTH3_k127_6342954_2 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000000000003819 100.0
DTH3_k127_6367201_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1067.0
DTH3_k127_6367201_1 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000004459 133.0
DTH3_k127_6418394_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 517.0
DTH3_k127_6418394_1 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000005085 143.0
DTH3_k127_6516767_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 599.0
DTH3_k127_6516767_1 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000003048 106.0
DTH3_k127_6534366_0 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001374 280.0
DTH3_k127_6534366_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000002656 166.0
DTH3_k127_6534366_2 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000007285 133.0
DTH3_k127_6586546_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006576 389.0
DTH3_k127_6586546_2 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.000007049 49.0
DTH3_k127_6601099_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 584.0
DTH3_k127_6601099_1 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 524.0
DTH3_k127_6620868_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000002792 158.0
DTH3_k127_6620868_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000006296 138.0
DTH3_k127_6620868_2 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000002915 87.0
DTH3_k127_6728593_0 Hypothetical methyltransferase - - - 0.000000000001013 78.0
DTH3_k127_6728593_1 NnrU protein K21310 - 2.1.1.334 0.00000000002154 70.0
DTH3_k127_6736856_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000006949 267.0
DTH3_k127_6736856_1 Domain of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000004506 237.0
DTH3_k127_6742938_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 571.0
DTH3_k127_6742938_1 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 343.0
DTH3_k127_6742938_2 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000005609 159.0
DTH3_k127_6742938_3 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000001333 132.0
DTH3_k127_6742938_4 Gar1/Naf1 RNA binding region K07569 - - 0.00000000001551 68.0
DTH3_k127_6742938_5 Acylphosphatase K01512 - 3.6.1.7 0.00000000002317 72.0
DTH3_k127_6760775_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 413.0
DTH3_k127_6760775_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000002216 190.0
DTH3_k127_6760775_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000008951 85.0
DTH3_k127_684020_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 320.0
DTH3_k127_684020_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000883 205.0
DTH3_k127_684020_2 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000002968 197.0
DTH3_k127_684020_3 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.00000000000000000000000000000000000000008388 156.0
DTH3_k127_6846514_0 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 449.0
DTH3_k127_6846514_1 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000002899 176.0
DTH3_k127_6846514_2 - - - - 0.000000000000000000000000000001574 126.0
DTH3_k127_6846514_3 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000002687 104.0
DTH3_k127_6961860_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 538.0
DTH3_k127_6961860_1 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 343.0
DTH3_k127_6961860_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000003243 209.0
DTH3_k127_6961860_3 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000001778 186.0
DTH3_k127_6970878_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 307.0
DTH3_k127_6970878_1 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000009202 205.0
DTH3_k127_6970878_2 DJ-1/PfpI family K03152 - 3.5.1.124 0.000000000000000000000000000000000000000000000000285 182.0
DTH3_k127_6976855_0 methyltransferase K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 351.0
DTH3_k127_6976855_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000005751 142.0
DTH3_k127_7010510_0 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 352.0
DTH3_k127_7010510_1 protein conserved in archaea K09723 - - 0.00000000000003931 79.0
DTH3_k127_7010510_2 to Saccharomyces cerevisiae NIT3 (YLR351C) K13566 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0050152,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:1990748 3.5.1.3 0.0000000003574 62.0
DTH3_k127_7010510_3 binds to the 23S rRNA K02929 - - 0.00000001195 56.0
DTH3_k127_7011226_0 - - - - 0.00000000000000000000000000000000000000003737 155.0
DTH3_k127_7011226_1 Superoxide dismutase K04564 - 1.15.1.1 0.00000000000000000000000000000000000004538 144.0
DTH3_k127_7011226_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000705 145.0
DTH3_k127_7014745_0 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000000389 197.0
DTH3_k127_7014745_1 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000001083 158.0
DTH3_k127_7014745_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000001573 159.0
DTH3_k127_7014745_3 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000003053 125.0
DTH3_k127_7014745_4 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000006914 108.0
DTH3_k127_7014745_5 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000001579 103.0
DTH3_k127_7014745_6 B-block binding subunit of TFIIIC - - - 0.00000000000000000000008225 102.0
DTH3_k127_7014745_7 NifU-like domain - - - 0.0000000000000000002748 89.0
DTH3_k127_7025146_0 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 305.0
DTH3_k127_7025146_1 ADP-ribosyl-(Dinitrogen reductase) hydrolase K05521 - 3.2.2.24 0.00000000000000000008586 101.0
DTH3_k127_703106_0 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006002 277.0
DTH3_k127_703106_1 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001093 258.0
DTH3_k127_703106_2 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000000000004123 220.0
DTH3_k127_703106_3 extracellular matrix structural constituent - - - 0.000000004758 67.0
DTH3_k127_7035872_0 KH, type 1, domain K07041 - - 8.068e-211 660.0
DTH3_k127_7035872_1 ArsR transcriptional regulator - - - 0.000000000000000000000000000000000000000000000008204 177.0
DTH3_k127_7035872_2 SMART regulatory protein, Crp K07730 - - 0.00000001937 55.0
DTH3_k127_7049827_0 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000002643 190.0
DTH3_k127_7049827_1 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000001967 175.0
DTH3_k127_7049827_2 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000134 84.0
DTH3_k127_7049827_3 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000003522 74.0
DTH3_k127_7100077_0 Required for chromosome condensation and partitioning K03529 - - 2.502e-296 947.0
DTH3_k127_7100077_1 Segregation and condensation protein ScpA K05896 - - 0.0000000000000001124 81.0
DTH3_k127_7100077_2 Sodium/calcium exchanger protein K07301 - - 0.0000002853 55.0
DTH3_k127_7123940_0 nuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001963 271.0
DTH3_k127_7123940_1 DEAD DEAH box helicase domain protein K10896 - - 0.000000000000000000000000000000000000000000000000000000000001127 217.0
DTH3_k127_7123940_2 CoA-binding domain protein K06929 - - 0.0000000000000000000000000006408 114.0
DTH3_k127_713212_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 456.0
DTH3_k127_713212_1 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002336 242.0
DTH3_k127_713212_2 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000672 138.0
DTH3_k127_713212_3 Histidine kinase - - - 0.000009353 48.0
DTH3_k127_7151685_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 500.0
DTH3_k127_7151685_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000001815 179.0
DTH3_k127_7151685_2 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000001607 176.0
DTH3_k127_7151685_3 Helix-turn-helix XRE-family like proteins K03627 - - 0.0000000000000000000000000000000000004904 145.0
DTH3_k127_7167541_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 419.0
DTH3_k127_7167541_1 Inorganic pyrophosphatase K15986 - 3.6.1.1 0.0000000000000859 74.0
DTH3_k127_7175853_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 541.0
DTH3_k127_7175853_1 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005196 387.0
DTH3_k127_7175853_2 Involved in protein export K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002166 251.0
DTH3_k127_7175853_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000004584 198.0
DTH3_k127_7245283_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 5.555e-243 761.0
DTH3_k127_7259484_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 537.0
DTH3_k127_7259484_1 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000002184 125.0
DTH3_k127_7271661_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 3.416e-214 678.0
DTH3_k127_7271661_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 492.0
DTH3_k127_7271661_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000005138 231.0
DTH3_k127_7271661_3 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.00000000000000000000000000000692 122.0
DTH3_k127_7271661_4 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000002368 98.0
DTH3_k127_7316935_0 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000002947 171.0
DTH3_k127_7316935_1 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000761 111.0
DTH3_k127_7316935_2 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.000000000003251 68.0
DTH3_k127_7316935_3 Universal stress protein family - - - 0.000004196 52.0
DTH3_k127_7332735_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 357.0
DTH3_k127_7332735_1 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 321.0
DTH3_k127_7332735_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000334 252.0
DTH3_k127_7332735_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000002632 228.0
DTH3_k127_7332735_4 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000008059 171.0
DTH3_k127_7332735_5 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000001887 160.0
DTH3_k127_7332735_6 Peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000003622 52.0
DTH3_k127_7347303_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 390.0
DTH3_k127_7347303_1 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000008044 154.0
DTH3_k127_7347303_2 Domain of unknown function (DUF4157) - - - 0.000000000000003238 83.0
DTH3_k127_7361686_0 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.0000000000000000000000000000000000009372 143.0
DTH3_k127_7361686_1 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.0000000001402 74.0
DTH3_k127_7361686_2 Thioredoxin-like - - - 0.0001262 54.0
DTH3_k127_7362017_0 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 440.0
DTH3_k127_7362017_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001177 273.0
DTH3_k127_7362017_2 PFAM molybdopterin oxidoreductase K00123,K05299 - 1.17.1.10,1.17.1.9 0.00000000000000000000000000000000000000000000003622 173.0
DTH3_k127_7407410_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 1.126e-223 697.0
DTH3_k127_7407410_1 PFAM Outer membrane efflux protein K18139 - - 0.0000000000000000000000000003727 118.0
DTH3_k127_7416206_0 pfam nmd3 K07562 - - 0.00000000000000000000000000000000000000000000000000001622 202.0
DTH3_k127_7416206_1 Protein of unknown function (DUF424) K09148 - - 0.00000000000000005251 85.0
DTH3_k127_7416206_2 ATPase involved in replication control, Cdc46 Mcm family K10726 - - 0.0000000098 58.0
DTH3_k127_7421141_0 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001203 259.0
DTH3_k127_7421141_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000009731 229.0
DTH3_k127_7449569_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000008029 207.0
DTH3_k127_7449569_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000002031 83.0
DTH3_k127_7465064_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 533.0
DTH3_k127_7465064_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000008106 242.0
DTH3_k127_7465064_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000003003 219.0
DTH3_k127_7465064_3 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000000002161 124.0
DTH3_k127_7465064_4 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000002354 62.0
DTH3_k127_7466744_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 367.0
DTH3_k127_7466744_1 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000001126 188.0
DTH3_k127_7466744_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000009171 71.0
DTH3_k127_7466744_3 Domain of unknown function (DUF4139) - - - 0.000002103 59.0
DTH3_k127_7470646_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 317.0
DTH3_k127_7470646_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001988 280.0
DTH3_k127_7490771_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 326.0
DTH3_k127_7490771_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003541 278.0
DTH3_k127_7490771_2 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000006235 221.0
DTH3_k127_7498602_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 571.0
DTH3_k127_7498602_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000003432 164.0
DTH3_k127_7508383_0 Cell division protein 48, CDC48, domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 583.0
DTH3_k127_7508383_1 PFAM PRC-barrel domain - - - 0.0000000000000005805 81.0
DTH3_k127_7508383_2 4Fe-4S dicluster domain - - - 0.00000000000008181 74.0
DTH3_k127_7526713_0 Ferrous iron transport protein B C terminus K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 375.0
DTH3_k127_7644468_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 597.0
DTH3_k127_7644468_1 Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000000001198 118.0
DTH3_k127_7658694_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000001455 244.0
DTH3_k127_767172_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 359.0
DTH3_k127_767172_1 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000009202 142.0
DTH3_k127_767172_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000001144 129.0
DTH3_k127_7783297_0 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000612 113.0
DTH3_k127_7783297_1 Sulfurtransferase K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.0000000002908 70.0
DTH3_k127_7822227_0 Sodium:solute symporter family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 413.0
DTH3_k127_7822227_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000004022 213.0
DTH3_k127_7848371_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 458.0
DTH3_k127_7861993_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 389.0
DTH3_k127_7861993_1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.0000000000000000001047 93.0
DTH3_k127_7861993_2 lysyltransferase activity K07027 - - 0.000000000000000001747 96.0
DTH3_k127_7870535_0 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.00000000000000000000000000000003442 134.0
DTH3_k127_7870535_1 Putative zinc- or iron-chelating domain K06940 - - 0.0000009533 56.0
DTH3_k127_7899295_0 Putative small multi-drug export protein - - - 0.000000000000000000000000000000000000000000000000009408 184.0
DTH3_k127_7899295_1 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000002371 156.0
DTH3_k127_7899295_2 - - - - 0.000000002666 59.0
DTH3_k127_7900857_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.954e-244 769.0
DTH3_k127_7900857_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 557.0
DTH3_k127_7900857_2 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000001509 107.0
DTH3_k127_7901405_0 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 351.0
DTH3_k127_7901405_1 COG0444 ABC-type dipeptide oligopeptide nickel transport system ATPase component K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 355.0
DTH3_k127_7901405_2 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 293.0
DTH3_k127_7901405_3 COGs COG0601 ABC-type dipeptide oligopeptide nickel transport systems permease components K02033 - - 0.000000000000000000000000000000000000000000000000001122 187.0
DTH3_k127_7914451_0 PFAM TrkA-N domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003106 297.0
DTH3_k127_7914451_1 COG3420 Nitrous oxidase accessory protein K07218 - - 0.0006113 50.0
DTH3_k127_7915065_0 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000001253 223.0
DTH3_k127_7915065_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000003874 148.0
DTH3_k127_7923657_0 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009016 269.0
DTH3_k127_7923657_1 domain protein - - - 0.00000002334 66.0
DTH3_k127_7923657_2 nucleoside recognition domain protein - - - 0.0000002238 53.0
DTH3_k127_7980862_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 363.0
DTH3_k127_7980862_1 Uncharacterized conserved protein (DUF2299) - - - 0.00000000000000000000000000000000005287 139.0
DTH3_k127_7980862_2 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.00000000000000000000000000006781 120.0
DTH3_k127_7980862_3 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000002941 66.0
DTH3_k127_7990356_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000002493 259.0
DTH3_k127_7990356_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000294 248.0
DTH3_k127_7990356_2 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000000000000000000000005834 158.0
DTH3_k127_8007303_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 571.0
DTH3_k127_8007303_1 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 384.0
DTH3_k127_8007303_2 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008334 256.0
DTH3_k127_8007303_3 Methanogenesis marker protein 5 - - - 0.000000000000000000000000000000000000000000000000000723 186.0
DTH3_k127_8007303_4 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000188 143.0
DTH3_k127_8007303_5 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000002855 136.0
DTH3_k127_8007303_6 Carboxymuconolactone decarboxylase family - - - 0.00002032 48.0
DTH3_k127_801432_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 590.0
DTH3_k127_801432_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 349.0
DTH3_k127_80350_0 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008602 287.0
DTH3_k127_80350_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000001005 209.0
DTH3_k127_80350_2 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000001265 212.0
DTH3_k127_80350_3 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000004188 176.0
DTH3_k127_80350_4 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000011 136.0
DTH3_k127_8048307_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001459 277.0
DTH3_k127_8048307_1 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000004248 137.0
DTH3_k127_8048307_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000004889 99.0
DTH3_k127_8062214_0 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 497.0
DTH3_k127_8062214_1 RNA ligase K07468 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 345.0
DTH3_k127_8062214_2 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000007326 208.0
DTH3_k127_8062214_3 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000006681 118.0
DTH3_k127_8093353_0 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000003692 254.0
DTH3_k127_8100466_0 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 361.0
DTH3_k127_8100466_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000002709 234.0
DTH3_k127_8100466_2 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.0000000000000000000000000000000000000000000000000006942 190.0
DTH3_k127_810964_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 430.0
DTH3_k127_810964_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000003622 218.0
DTH3_k127_8119996_0 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000595 275.0
DTH3_k127_8119996_1 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000567 169.0
DTH3_k127_8119996_2 Protein of unknown function DUF72 - - - 0.000009161 49.0
DTH3_k127_8132928_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 7.006e-288 900.0
DTH3_k127_8132928_1 ATPases associated with a variety of cellular activities K00400 - - 0.000000000000000000000000000000006041 131.0
DTH3_k127_8139638_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 331.0
DTH3_k127_8139638_1 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000003627 168.0
DTH3_k127_8145567_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000378 200.0
DTH3_k127_8145567_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000007261 190.0
DTH3_k127_8145567_2 archaeal Zn-finger protein - - - 0.0000000000000000000000001061 113.0
DTH3_k127_8145567_3 3-demethylubiquinone-9 3-methyltransferase - - - 0.0001857 44.0
DTH3_k127_8149913_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 468.0
DTH3_k127_8149913_1 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.0000000000000000000000000003351 118.0
DTH3_k127_8149913_2 PFAM ABC transporter related K09013 - - 0.00003723 46.0
DTH3_k127_8185576_0 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 302.0
DTH3_k127_8185576_1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K22167 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000003844 237.0
DTH3_k127_8185576_2 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K22166 - 1.5.98.3 0.0000000000000000000000000000000002806 135.0
DTH3_k127_8185576_3 4Fe-4S dicluster domain K22164 - 1.5.98.3 0.000000000000000000000003688 109.0
DTH3_k127_8185576_4 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.0000000000000009873 82.0
DTH3_k127_8185576_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K22165 - 1.5.98.3 0.00002493 50.0
DTH3_k127_8199527_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 3.24e-231 726.0
DTH3_k127_8247537_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000116 258.0
DTH3_k127_8247537_1 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000001137 226.0
DTH3_k127_8247537_2 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.0000000000000000000000000000001593 128.0
DTH3_k127_8247537_3 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000002794 61.0
DTH3_k127_8267008_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000005756 184.0
DTH3_k127_8267008_1 - - - - 0.000000000002297 71.0
DTH3_k127_8271924_0 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 427.0
DTH3_k127_8271924_1 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000003905 117.0
DTH3_k127_8271924_2 - - - - 0.00000000015 68.0
DTH3_k127_8293954_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000005908 193.0
DTH3_k127_8293954_1 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000009881 50.0
DTH3_k127_8328519_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 474.0
DTH3_k127_8328519_1 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.00000000000000000000000000000000000000000000000000000002103 207.0
DTH3_k127_8332849_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 321.0
DTH3_k127_8332849_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000173 116.0
DTH3_k127_8332849_2 toxin-antitoxin pair type II binding - - - 0.0000000000005788 69.0
DTH3_k127_8341172_0 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 516.0
DTH3_k127_8341172_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000005092 201.0
DTH3_k127_8341172_2 Cupin domain - - - 0.00000000000000000000009332 102.0
DTH3_k127_8343672_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 525.0
DTH3_k127_8343672_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 404.0
DTH3_k127_8343672_2 PFAM TfuA domain protein, core - - - 0.000000000000000000000000000000000000000000000000000000000000000000001551 243.0
DTH3_k127_8343672_3 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000002268 61.0
DTH3_k127_8343672_4 Thioesterase superfamily K02614 - - 0.000001888 50.0
DTH3_k127_8343672_5 PFAM PP-loop domain protein - - - 0.00001147 49.0
DTH3_k127_8348609_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 7.24e-242 757.0
DTH3_k127_8348609_1 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 331.0
DTH3_k127_8350684_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 544.0
DTH3_k127_8350684_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 364.0
DTH3_k127_8350684_2 GTP-binding protein K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 315.0
DTH3_k127_8350684_3 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000000000000004443 139.0
DTH3_k127_8350684_4 Zn-ribbon containing protein K07163 - - 0.00000000000000000000007504 104.0
DTH3_k127_8350684_5 Mo-molybdopterin cofactor metabolic process - - - 0.00001126 49.0
DTH3_k127_8351900_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 362.0
DTH3_k127_8351900_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008965 270.0
DTH3_k127_8351900_2 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000009847 220.0
DTH3_k127_8351900_3 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000005738 123.0
DTH3_k127_8380860_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 376.0
DTH3_k127_8380860_1 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 312.0
DTH3_k127_8380860_2 PFAM blue (type 1) copper domain protein - - - 0.0000000000001614 83.0
DTH3_k127_8396306_0 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000009073 194.0
DTH3_k127_8396306_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.0000000000000000000000000000000000000000000000000003474 190.0
DTH3_k127_8396306_2 toxin-antitoxin pair type II binding - - - 0.00000000000000000000000001873 110.0
DTH3_k127_8396306_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000000000000002326 90.0
DTH3_k127_8396306_4 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.00000000000004131 74.0
DTH3_k127_8401461_0 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000002884 230.0
DTH3_k127_8401461_1 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000002826 81.0
DTH3_k127_8413435_0 Hydantoinase/oxoprolinase N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 475.0
DTH3_k127_8413435_1 Papain-like cysteine protease AvrRpt2 - - - 0.0000000000000000000000000000000000002485 149.0
DTH3_k127_8417439_0 Glycogen synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 317.0
DTH3_k127_8417439_1 Circadian clock protein KaiC - - - 0.000000000000000000000000000000000000000000000000000000000000000000002079 243.0
DTH3_k127_8417439_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000002986 61.0
DTH3_k127_8448195_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 499.0
DTH3_k127_8448195_1 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000001048 128.0
DTH3_k127_8472701_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000935 537.0
DTH3_k127_8472701_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 343.0
DTH3_k127_8472701_2 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000000000000001226 184.0
DTH3_k127_8474655_0 PFAM PilT protein domain protein K06865 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 544.0
DTH3_k127_8501835_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004073 569.0
DTH3_k127_8512743_0 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 383.0
DTH3_k127_8512743_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000003884 231.0
DTH3_k127_855240_0 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008555 332.0
DTH3_k127_855240_1 Clp protease K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 298.0
DTH3_k127_855240_2 Belongs to the UPF0218 family K09735 - - 0.0000000000000000000000000000000000000000004203 162.0
DTH3_k127_855240_3 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000004404 105.0
DTH3_k127_855240_4 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000001799 85.0
DTH3_k127_8640470_0 ATPases associated with a variety of cellular activities K00400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 544.0
DTH3_k127_8640470_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 360.0
DTH3_k127_8640470_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 324.0
DTH3_k127_8674583_0 domain protein K01342,K06894,K12287,K20276 - 3.4.21.62 0.00000257 60.0
DTH3_k127_8684967_0 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 366.0
DTH3_k127_8684967_1 formylmethanofuran dehydrogenase, subunit G K11260 - - 0.000000000000000001281 87.0
DTH3_k127_8684967_2 von Willebrand factor (vWF) type A domain - - - 0.00000001946 62.0
DTH3_k127_8699193_0 Periplasmic copper-binding protein (NosD) - - - 0.00007933 55.0
DTH3_k127_8711606_0 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.000000000000000000000000000000000000000000002869 169.0
DTH3_k127_8711606_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000009384 160.0
DTH3_k127_8711606_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000003699 122.0
DTH3_k127_8711606_3 metal ion binding - - - 0.000000000000000000000002473 108.0
DTH3_k127_8711606_4 Belongs to the UPF0235 family K09131 - - 0.000000000000000003003 88.0
DTH3_k127_8828011_0 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 349.0
DTH3_k127_8828011_1 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000000001342 128.0
DTH3_k127_8828011_2 Major facilitator superfamily - - - 0.000000000000000000000000008287 118.0
DTH3_k127_8828011_3 Lrp/AsnC ligand binding domain - - - 0.00000000000000001126 84.0
DTH3_k127_8828011_4 Tetratricopeptide repeat - - - 0.0000000000000000243 91.0
DTH3_k127_8849076_0 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000002123 216.0
DTH3_k127_8849076_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000003917 186.0
DTH3_k127_8849076_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000006769 180.0
DTH3_k127_8849076_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.00000000000000001311 83.0
DTH3_k127_8859278_0 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 577.0
DTH3_k127_8859278_1 Metallo-beta-lactamase superfamily K06897 GO:0003674,GO:0003824,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0042558,GO:0044237,GO:0044249,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901564 2.5.1.105 0.0000000000000003571 81.0
DTH3_k127_8859278_2 Belongs to the UPF0280 family K09740 - - 0.000000000000000428 80.0
DTH3_k127_8925785_0 Domain of unknown function (DUF1890) - - - 0.00000000000000000000000000000000000000000000000000004041 190.0
DTH3_k127_8925785_1 Molybdopterin converting factor K03635 - 2.8.1.12 0.00000000000000000000000000000000000001423 148.0
DTH3_k127_8925785_2 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000000000002476 146.0
DTH3_k127_8925785_3 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000001035 122.0
DTH3_k127_8925785_4 - - - - 0.0000000000000000000002271 101.0
DTH3_k127_8925785_5 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K02239 - - 0.0000000000000000000004974 100.0
DTH3_k127_8925785_6 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000000003386 84.0
DTH3_k127_8939974_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 385.0
DTH3_k127_8939974_1 Pentapeptide repeats (9 copies) - - - 0.0000000000007563 81.0
DTH3_k127_8939974_2 PFAM Pentapeptide repeats (8 copies) - - - 0.00000000005625 75.0
DTH3_k127_8952703_0 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 282.0
DTH3_k127_8952703_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002315 256.0
DTH3_k127_8952703_2 AMMECR1 K09141 - - 0.0000000000000000000000004339 109.0
DTH3_k127_8954367_0 Iron-sulfur cluster-binding domain K06871 - - 1.277e-203 642.0
DTH3_k127_8954367_1 transcriptional - - - 0.000000000000000000000000000000000000000008458 155.0
DTH3_k127_8978785_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005374 254.0
DTH3_k127_8978785_1 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000002336 175.0
DTH3_k127_8989421_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 292.0
DTH3_k127_8989421_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000001343 173.0
DTH3_k127_8989421_2 adenyl ribonucleotide binding - - - 0.00000000000000000000000004851 113.0
DTH3_k127_9025066_0 shikimate kinase activity K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 301.0
DTH3_k127_9025066_1 Chorismate mutase type II K04093 - 5.4.99.5 0.0007843 43.0
DTH3_k127_9054910_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 4.101e-260 820.0
DTH3_k127_9061895_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 407.0
DTH3_k127_9061895_1 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000000001249 231.0
DTH3_k127_9061895_2 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000000000000000000000000000000004147 183.0
DTH3_k127_9061895_3 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000004446 102.0
DTH3_k127_9061895_4 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000421 95.0
DTH3_k127_9061895_5 structural constituent of ribosome K02924 - - 0.00000000000001334 76.0
DTH3_k127_9061895_6 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.00000000001525 69.0
DTH3_k127_9100911_0 eRF1 domain 2 - - - 0.0000000000000000000000004405 116.0
DTH3_k127_9100911_1 Leucine rich repeat variant - - - 0.000000000133 72.0
DTH3_k127_9143062_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 563.0
DTH3_k127_9143062_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000003144 153.0
DTH3_k127_9143062_2 methyltransferase - - - 0.000000000001523 69.0
DTH3_k127_93032_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 366.0
DTH3_k127_93032_1 Belongs to the UPF0434 family - - - 0.0000000001115 62.0
DTH3_k127_9343059_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 398.0
DTH3_k127_9343059_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000008748 139.0
DTH3_k127_9343059_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000002679 85.0
DTH3_k127_9343059_3 - K00960 - 2.7.7.6 0.0000000000000003992 79.0
DTH3_k127_9350830_0 in RNase L inhibitor, RLI K06174 - - 3.918e-244 766.0
DTH3_k127_9350830_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000004936 220.0
DTH3_k127_9350830_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000004132 98.0
DTH3_k127_9350830_3 PIN domain of ribonuclease K07060 - - 0.0000000000000000000005331 104.0
DTH3_k127_9350830_4 RNase L inhibitor, RLI - - - 0.0000000000000000000013 101.0
DTH3_k127_9395313_0 Segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000005198 151.0
DTH3_k127_9395313_1 Winged helix-turn-helix - - - 0.000006434 48.0
DTH3_k127_9395313_2 Required for chromosome condensation and partitioning K03529 - - 0.00006046 46.0
DTH3_k127_990527_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000005384 207.0
DTH3_k127_990527_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000006505 172.0
DTH3_k127_990527_2 Cupin domain - - - 0.000000000000000000000000000000000001035 143.0
DTH3_k127_990527_3 Winged helix-turn-helix DNA-binding - - - 0.000000000926 63.0
DTH3_k127_990527_4 TPR repeat-containing thioredoxin - GO:0001101,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009787,GO:0009789,GO:0009966,GO:0009967,GO:0010033,GO:0010646,GO:0010647,GO:0023051,GO:0023056,GO:0033993,GO:0042221,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0097305,GO:1901419,GO:1901421,GO:1901700,GO:1905957,GO:1905959 - 0.0001317 49.0
DTH3_k127_990527_5 tetratricopeptide repeat - - - 0.0001385 46.0