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Overview

ID MAG01044
Name EH2_bin.22
Sample SMP0029
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species UBA9949 sp028679275
Assembly information
Completeness (%) 86.82
Contamination (%) 3.18
GC content (%) 54.0
N50 (bp) 12,772
Genome size (bp) 1,585,641

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1678

Gene name Description KEGG GOs EC E-value Score Sequence
EH2_k127_1036105_0 Domain of unknown function (DUF1724) - - - 0.000000000000000000000000000000000000000000000000000000000000000000916 236.0
EH2_k127_1036105_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000001392 204.0
EH2_k127_1036105_2 Belongs to the UPF0216 family K09737 - - 0.00000000000000000000000000000000000000001887 156.0
EH2_k127_1036105_3 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000001291 139.0
EH2_k127_1050740_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 1.454e-240 748.0
EH2_k127_1050740_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.657e-233 726.0
EH2_k127_1050740_2 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 595.0
EH2_k127_1050740_3 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006179 574.0
EH2_k127_1050740_4 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 464.0
EH2_k127_1050740_5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 311.0
EH2_k127_1050740_6 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002185 216.0
EH2_k127_1050740_7 TIGRFAM molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000001662 162.0
EH2_k127_1050740_8 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000000000173 110.0
EH2_k127_1061513_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0 1018.0
EH2_k127_1061513_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.222e-242 758.0
EH2_k127_1061513_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 611.0
EH2_k127_1061513_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 356.0
EH2_k127_1061513_4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 338.0
EH2_k127_1061513_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003111 278.0
EH2_k127_1061513_6 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000000000000000002504 154.0
EH2_k127_1061513_7 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000003021 92.0
EH2_k127_1101414_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.09e-307 967.0
EH2_k127_1101414_1 Protein of unknown function, DUF255 K06888 - - 2.173e-218 698.0
EH2_k127_1101414_10 Rhodanese-like domain K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 539.0
EH2_k127_1101414_11 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 495.0
EH2_k127_1101414_12 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 474.0
EH2_k127_1101414_13 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 437.0
EH2_k127_1101414_14 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 413.0
EH2_k127_1101414_15 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 387.0
EH2_k127_1101414_16 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 382.0
EH2_k127_1101414_17 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 363.0
EH2_k127_1101414_18 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 370.0
EH2_k127_1101414_19 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 354.0
EH2_k127_1101414_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 2.157e-201 640.0
EH2_k127_1101414_20 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 348.0
EH2_k127_1101414_21 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 331.0
EH2_k127_1101414_22 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 318.0
EH2_k127_1101414_23 SMART Peptidase A22, presenilin signal peptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 313.0
EH2_k127_1101414_24 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 296.0
EH2_k127_1101414_25 PFAM HhH-GPD family protein K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001814 286.0
EH2_k127_1101414_26 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007042 271.0
EH2_k127_1101414_27 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001617 267.0
EH2_k127_1101414_28 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000759 261.0
EH2_k127_1101414_29 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000001833 244.0
EH2_k127_1101414_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 5.905e-197 621.0
EH2_k127_1101414_30 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000003383 233.0
EH2_k127_1101414_31 protein conserved in bacteria (DUF2179) - - - 0.000000000000000000000000000000000000000000000000000000000000001163 224.0
EH2_k127_1101414_32 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000004406 224.0
EH2_k127_1101414_33 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000008534 216.0
EH2_k127_1101414_34 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000001774 216.0
EH2_k127_1101414_35 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000002648 212.0
EH2_k127_1101414_36 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000008405 212.0
EH2_k127_1101414_37 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.00000000000000000000000000000000000000000000000000000000001026 215.0
EH2_k127_1101414_38 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000381 209.0
EH2_k127_1101414_39 Domain of unknown function (DUF1890) - - - 0.0000000000000000000000000000000000000000000000000000000919 199.0
EH2_k127_1101414_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 7.724e-197 623.0
EH2_k127_1101414_40 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000002318 183.0
EH2_k127_1101414_41 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000000000002128 181.0
EH2_k127_1101414_42 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000003864 178.0
EH2_k127_1101414_43 PFAM Pyridoxamine 5'-phosphate - - - 0.0000000000000000000000000000000000000000000197 168.0
EH2_k127_1101414_44 Protein of unknown function (DUF2769) - - - 0.0000000000000000000000000000000000000002817 151.0
EH2_k127_1101414_45 PFAM PRC-barrel domain - - - 0.0000000000000000000000000000004274 123.0
EH2_k127_1101414_46 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000001051 115.0
EH2_k127_1101414_47 Cobalamin biosynthesis protein CbiG K02189 - 3.7.1.12 0.00000000000000000000000001259 121.0
EH2_k127_1101414_49 Domain of unknown function (DUF1894) - - - 0.00000000000003965 76.0
EH2_k127_1101414_5 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007839 593.0
EH2_k127_1101414_50 - - - - 0.0000000000003611 76.0
EH2_k127_1101414_51 - - - - 0.000009705 49.0
EH2_k127_1101414_52 - - - - 0.0003912 43.0
EH2_k127_1101414_6 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 559.0
EH2_k127_1101414_7 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 564.0
EH2_k127_1101414_8 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009562 557.0
EH2_k127_1101414_9 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 562.0
EH2_k127_1128113_0 Uncharacterized membrane protein (DUF2298) - - - 1.902e-222 709.0
EH2_k127_1128113_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 8.138e-207 648.0
EH2_k127_1128113_10 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 494.0
EH2_k127_1128113_11 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 429.0
EH2_k127_1128113_12 Belongs to the UPF0285 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 401.0
EH2_k127_1128113_13 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 359.0
EH2_k127_1128113_14 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 310.0
EH2_k127_1128113_15 Co Zn Cd efflux system component K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 310.0
EH2_k127_1128113_16 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000138 280.0
EH2_k127_1128113_17 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001178 280.0
EH2_k127_1128113_18 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001621 282.0
EH2_k127_1128113_19 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000001564 235.0
EH2_k127_1128113_2 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 6.847e-198 621.0
EH2_k127_1128113_20 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000008776 213.0
EH2_k127_1128113_21 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000007551 205.0
EH2_k127_1128113_22 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.00000000000000000000000000000000000000000000000000000003268 198.0
EH2_k127_1128113_23 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000001105 190.0
EH2_k127_1128113_24 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000001681 173.0
EH2_k127_1128113_25 - - - - 0.0000000000000000000000000000000000000000013 170.0
EH2_k127_1128113_26 - - - - 0.00000000000000000000000000000000000000001511 161.0
EH2_k127_1128113_27 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000046 149.0
EH2_k127_1128113_28 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000002887 134.0
EH2_k127_1128113_29 - - - - 0.0000000000000000000000000000000003704 134.0
EH2_k127_1128113_3 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 599.0
EH2_k127_1128113_30 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000004061 129.0
EH2_k127_1128113_31 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000000005019 120.0
EH2_k127_1128113_32 helicase activity K06915 - - 0.000000000000000000000000006572 117.0
EH2_k127_1128113_33 Involved in cell shape control K22222 - - 0.0000000000000000000002354 96.0
EH2_k127_1128113_34 - - - - 0.000000001775 61.0
EH2_k127_1128113_35 - - - - 0.000000002646 64.0
EH2_k127_1128113_36 PFAM Tetratricopeptide repeat - - - 0.00002435 51.0
EH2_k127_1128113_4 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 595.0
EH2_k127_1128113_5 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 571.0
EH2_k127_1128113_6 PFAM Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 535.0
EH2_k127_1128113_7 Involved in cell shape control K22222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 526.0
EH2_k127_1128113_8 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 530.0
EH2_k127_1128113_9 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 499.0
EH2_k127_124636_0 PFAM CBS domain - - - 1.78e-256 798.0
EH2_k127_124636_1 ATP-grasp domain K06913 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 397.0
EH2_k127_124636_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000215 191.0
EH2_k127_124636_11 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.0000000000000000000000000000000000000000000759 165.0
EH2_k127_124636_12 - - - - 0.0000000000000000000000000000000001123 144.0
EH2_k127_124636_13 zinc finger, SWIM - - - 0.000000000000000000000000000000001971 132.0
EH2_k127_124636_14 - - - - 0.00000000000000000000000000001341 122.0
EH2_k127_124636_15 - - - - 0.00000000000000000000005177 102.0
EH2_k127_124636_2 Methanogenesis marker protein 8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 321.0
EH2_k127_124636_3 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 287.0
EH2_k127_124636_4 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002049 271.0
EH2_k127_124636_5 PFAM Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009318 268.0
EH2_k127_124636_6 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001804 258.0
EH2_k127_124636_7 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000000000000000000000000001335 241.0
EH2_k127_124636_8 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000008101 249.0
EH2_k127_124636_9 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000000002917 225.0
EH2_k127_1363012_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1482.0
EH2_k127_1363012_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 2.534e-238 751.0
EH2_k127_1363012_10 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001201 252.0
EH2_k127_1363012_11 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.000000000000000000009948 92.0
EH2_k127_1363012_12 - - - - 0.0000000000000001664 80.0
EH2_k127_1363012_13 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000005707 57.0
EH2_k127_1363012_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.131e-198 623.0
EH2_k127_1363012_3 PFAM Aldehyde dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007977 556.0
EH2_k127_1363012_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 431.0
EH2_k127_1363012_5 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004836 415.0
EH2_k127_1363012_6 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 355.0
EH2_k127_1363012_7 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 318.0
EH2_k127_1363012_8 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 291.0
EH2_k127_1363012_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004466 255.0
EH2_k127_1375576_0 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000001624 250.0
EH2_k127_1375576_1 TIGRFAM methyltransferase FkbM family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001755 235.0
EH2_k127_1375576_2 Endonuclease related to archaeal Holliday junction resolvase - - - 0.00000000000000000000000000000000000000000000000000000000244 205.0
EH2_k127_1375576_3 TIR domain - - - 0.000000000000000000000000000000000000000000000002191 192.0
EH2_k127_1375576_4 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000003044 169.0
EH2_k127_1375576_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000179 134.0
EH2_k127_1375576_6 Short repeat of unknown function (DUF308) - - - 0.0000006385 58.0
EH2_k127_1375576_7 E-Z type HEAT repeats - - - 0.000001513 55.0
EH2_k127_1375576_8 - - - - 0.0000205 50.0
EH2_k127_142144_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 3.895e-241 758.0
EH2_k127_142144_1 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 579.0
EH2_k127_142144_10 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006672 276.0
EH2_k127_142144_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000021 267.0
EH2_k127_142144_12 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000001149 231.0
EH2_k127_142144_13 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000005333 196.0
EH2_k127_142144_14 - - - - 0.000000000000000000000000000000000000000000000000000005344 196.0
EH2_k127_142144_15 COG0518 GMP synthase - Glutamine amidotransferase domain K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000001534 196.0
EH2_k127_142144_16 RNase_H superfamily K07502 - - 0.00000000000000000002094 97.0
EH2_k127_142144_17 Glycosyl transferase 4-like - - - 0.000000002207 68.0
EH2_k127_142144_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 540.0
EH2_k127_142144_3 MviN-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 513.0
EH2_k127_142144_4 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 505.0
EH2_k127_142144_5 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 456.0
EH2_k127_142144_6 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 454.0
EH2_k127_142144_7 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 443.0
EH2_k127_142144_8 PFAM PEGA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 292.0
EH2_k127_142144_9 sugar phosphatases of the HAD superfamily K02566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003521 281.0
EH2_k127_142229_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 607.0
EH2_k127_142229_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 406.0
EH2_k127_142229_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 312.0
EH2_k127_142229_3 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000003206 248.0
EH2_k127_142229_4 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000000004645 113.0
EH2_k127_142229_5 methanogen marker protein 4 - - - 0.000000000001975 67.0
EH2_k127_1448772_0 PFAM DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 367.0
EH2_k127_1448772_1 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000000000000000000000000000000000000004731 241.0
EH2_k127_1448772_2 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000176 127.0
EH2_k127_1448772_3 - - - - 0.0000000000000001077 86.0
EH2_k127_1549389_0 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 512.0
EH2_k127_1549389_1 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 430.0
EH2_k127_1549389_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000008171 263.0
EH2_k127_1549389_3 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000915 261.0
EH2_k127_1549389_4 PFAM Phosphatidylglycerophosphatase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000007943 233.0
EH2_k127_1549389_5 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000000004602 198.0
EH2_k127_1549389_6 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000002425 188.0
EH2_k127_1549389_7 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000002794 173.0
EH2_k127_174674_0 Radical SAM K06871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 375.0
EH2_k127_174674_1 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 349.0
EH2_k127_174674_2 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000266 252.0
EH2_k127_174674_3 - - - - 0.000000000000000000000000000000000000000000000000003949 188.0
EH2_k127_174674_4 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000002377 169.0
EH2_k127_174674_5 membrane protein of uknown function UCP014873 - - - 0.0000000000000000000002538 104.0
EH2_k127_174674_6 Uncharacterized protein family, UPF0114 - - - 0.00000000000009785 76.0
EH2_k127_174674_7 Short C-terminal domain - - - 0.0000007814 57.0
EH2_k127_174674_8 - - - - 0.00002216 53.0
EH2_k127_1817638_0 CBS domain K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 366.0
EH2_k127_1817638_1 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000004424 209.0
EH2_k127_1817638_2 COG1174 ABC-type proline glycine betaine transport systems, permease component K05846 - - 0.00000000000000000000000000000000000000000127 165.0
EH2_k127_1817638_3 COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) K05845,K05846 - - 0.00000000000000000000000000000000003095 138.0
EH2_k127_1953395_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 2.412e-281 878.0
EH2_k127_1953395_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 615.0
EH2_k127_1953395_10 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000004229 168.0
EH2_k127_1953395_11 Flavodoxin - - - 0.000000000000000000000000000002159 126.0
EH2_k127_1953395_12 - - - - 0.00000000000003214 81.0
EH2_k127_1953395_2 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 530.0
EH2_k127_1953395_3 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases K20616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 354.0
EH2_k127_1953395_4 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 329.0
EH2_k127_1953395_5 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 301.0
EH2_k127_1953395_6 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000001234 267.0
EH2_k127_1953395_7 COG1233 Phytoene dehydrogenase and related proteins K10027,K20611 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,1.3.99.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000001711 258.0
EH2_k127_1953395_8 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000007359 255.0
EH2_k127_1953395_9 Carotene biosynthesis associated membrane protein K08977 - 4.2.1.161 0.0000000000000000000000000000000000000000000000015 183.0
EH2_k127_2059719_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 584.0
EH2_k127_2059719_1 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 543.0
EH2_k127_2059719_2 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009315 285.0
EH2_k127_2059719_3 phosphatidylinositol metabolic process K00728 - 2.4.1.109 0.000000000000000000000000000000000001321 156.0
EH2_k127_2059719_4 - K00960 - 2.7.7.6 0.0000000000000000000000001439 106.0
EH2_k127_2059719_5 Protein of unknown function (DUF2769) - - - 0.000000000000000000004939 96.0
EH2_k127_2059719_6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000005835 61.0
EH2_k127_2091506_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004751 270.0
EH2_k127_2091506_1 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000001336 121.0
EH2_k127_2091506_2 - - - - 0.0000000000000000000000003725 107.0
EH2_k127_2091506_3 Ferric reductase like transmembrane component - - - 0.000000000000000000000003618 111.0
EH2_k127_2091506_4 TIR domain - - - 0.000000000000000001691 91.0
EH2_k127_2093553_0 helicase activity - - - 2.521e-245 782.0
EH2_k127_2093553_1 PFAM ribonuclease II K01147 - 3.1.13.1 6.361e-220 695.0
EH2_k127_2093553_10 - K06193 - - 0.00003421 49.0
EH2_k127_2093553_2 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 523.0
EH2_k127_2093553_3 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 394.0
EH2_k127_2093553_4 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 384.0
EH2_k127_2093553_5 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 295.0
EH2_k127_2093553_6 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000000000000000008324 226.0
EH2_k127_2093553_7 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000009133 208.0
EH2_k127_2093553_8 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000001345 177.0
EH2_k127_2097321_0 ATPases associated with a variety of cellular activities K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 363.0
EH2_k127_2097321_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 350.0
EH2_k127_2097321_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000003928 104.0
EH2_k127_2197959_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 581.0
EH2_k127_2197959_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000001926 218.0
EH2_k127_2197959_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000000000004594 184.0
EH2_k127_2207255_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000565 606.0
EH2_k127_2207255_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 589.0
EH2_k127_2207255_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 546.0
EH2_k127_2207255_3 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 332.0
EH2_k127_2207255_4 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 292.0
EH2_k127_2207255_5 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000000000001739 258.0
EH2_k127_2207255_6 PFAM methyltransferase small K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000007702 216.0
EH2_k127_2207255_7 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000000000000000000000349 176.0
EH2_k127_2207255_8 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000000000000000003899 152.0
EH2_k127_2207255_9 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000009259 56.0
EH2_k127_2219449_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 8.244e-298 921.0
EH2_k127_2219449_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 9.61e-259 802.0
EH2_k127_2219449_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 301.0
EH2_k127_2219449_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000225 271.0
EH2_k127_2219449_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00002545 50.0
EH2_k127_2219449_5 - - - - 0.00008172 47.0
EH2_k127_2232735_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.527e-279 873.0
EH2_k127_2232735_1 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 556.0
EH2_k127_2232735_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 543.0
EH2_k127_2232735_3 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006575 532.0
EH2_k127_2232735_4 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 377.0
EH2_k127_2232735_5 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 342.0
EH2_k127_2232735_6 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 334.0
EH2_k127_2232735_7 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000004345 211.0
EH2_k127_2232735_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.000000000000000000000000000000000009156 139.0
EH2_k127_2307203_0 radical SAM K06871 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005893 258.0
EH2_k127_2307203_1 - K02478 - 2.7.13.3 0.000000000000000000000000000000000002587 140.0
EH2_k127_2307203_2 defense response to virus K07061 - - 0.0000000000000000000000000000001818 129.0
EH2_k127_2307203_3 - - - - 0.000000000000000000000000000005115 123.0
EH2_k127_2307203_5 - K02478 - 2.7.13.3 0.000000000000000000000001768 104.0
EH2_k127_2307203_6 - K02478 - 2.7.13.3 0.0000000000000000000002402 99.0
EH2_k127_2307203_7 Prokaryotic RING finger family 2 - - - 0.00000001424 59.0
EH2_k127_2307203_8 VIT family - - - 0.00000072 59.0
EH2_k127_2323638_0 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 310.0
EH2_k127_2323638_1 Protein of unknown function (DUF1670) - - - 0.00000000000000000000000000005574 121.0
EH2_k127_2323638_2 signal-transduction protein containing cAMP-binding and CBS domains K10716 - - 0.000000000000000000000000004349 121.0
EH2_k127_2323638_3 cheY-homologous receiver domain K07658 - - 0.000000000000000000004438 107.0
EH2_k127_2323638_4 PFAM Beta propeller domain K14475 - - 0.000002815 55.0
EH2_k127_2408498_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 572.0
EH2_k127_2408498_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 357.0
EH2_k127_2408498_10 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000000002126 96.0
EH2_k127_2408498_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 282.0
EH2_k127_2408498_3 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000271 239.0
EH2_k127_2408498_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000000779 221.0
EH2_k127_2408498_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000002038 218.0
EH2_k127_2408498_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000001451 214.0
EH2_k127_2408498_7 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000000000000000000000000000886 182.0
EH2_k127_2408498_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000004446 122.0
EH2_k127_2408498_9 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000001952 106.0
EH2_k127_2408777_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 454.0
EH2_k127_2408777_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007274 389.0
EH2_k127_2408777_2 protein involved in the oxidation of intracellular sulfur K07235,K07236 - - 0.000000000000000000000000000000000000000000000000000000000000004138 231.0
EH2_k127_2408777_3 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000002646 176.0
EH2_k127_2408777_4 Cupin 2 conserved barrel domain - - - 0.0000000000000000000007448 98.0
EH2_k127_2430784_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1332.0
EH2_k127_2430784_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1140.0
EH2_k127_2430784_10 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006637 314.0
EH2_k127_2430784_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 299.0
EH2_k127_2430784_12 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002 278.0
EH2_k127_2430784_13 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000009094 189.0
EH2_k127_2430784_14 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000000000000002887 178.0
EH2_k127_2430784_15 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000000000000000000359 172.0
EH2_k127_2430784_16 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000000000000000000000000008971 160.0
EH2_k127_2430784_17 - - - - 0.000000000000000000000000000000000000000568 150.0
EH2_k127_2430784_18 PDGLE domain K02009 - - 0.00000000000000000000000000000005551 128.0
EH2_k127_2430784_19 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000000001709 113.0
EH2_k127_2430784_2 DEAD DEAH box helicase domain protein K10896 - - 1.647e-296 927.0
EH2_k127_2430784_20 beta-fructofuranosidase activity - - - 0.000000000000001813 90.0
EH2_k127_2430784_3 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.905e-282 876.0
EH2_k127_2430784_4 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 462.0
EH2_k127_2430784_5 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 440.0
EH2_k127_2430784_6 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 417.0
EH2_k127_2430784_7 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 352.0
EH2_k127_2430784_8 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 349.0
EH2_k127_2430784_9 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 335.0
EH2_k127_2510106_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 557.0
EH2_k127_2510106_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 495.0
EH2_k127_2510106_10 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000004804 267.0
EH2_k127_2510106_11 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002579 259.0
EH2_k127_2510106_12 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000001242 157.0
EH2_k127_2510106_13 secretion by the type IV secretion system K07332 - - 0.00000000000000000000000007197 117.0
EH2_k127_2510106_14 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000001817 108.0
EH2_k127_2510106_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 467.0
EH2_k127_2510106_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 439.0
EH2_k127_2510106_4 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 435.0
EH2_k127_2510106_5 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 381.0
EH2_k127_2510106_6 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000841 382.0
EH2_k127_2510106_7 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 375.0
EH2_k127_2510106_8 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 284.0
EH2_k127_2510106_9 Oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007992 275.0
EH2_k127_2558411_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 565.0
EH2_k127_2558411_1 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 444.0
EH2_k127_2558411_2 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 327.0
EH2_k127_2558411_3 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005536 238.0
EH2_k127_2558411_4 protein kinase activity - - - 0.000000002179 68.0
EH2_k127_2587266_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 2.902e-280 871.0
EH2_k127_2587266_1 Belongs to the RtcB family K14415 - 6.5.1.3 5.621e-226 707.0
EH2_k127_2587266_10 Protein of unknown function (DUF2551) - - - 0.00000000000000000000000000000005035 127.0
EH2_k127_2587266_11 - - - - 0.000000000000000000000008473 103.0
EH2_k127_2587266_12 Protein-export membrane protein SecD K03072 - - 0.00000000000004158 74.0
EH2_k127_2587266_2 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 507.0
EH2_k127_2587266_3 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 371.0
EH2_k127_2587266_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002774 231.0
EH2_k127_2587266_5 PFAM ABC transporter K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000001929 228.0
EH2_k127_2587266_6 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000000001152 209.0
EH2_k127_2587266_7 PFAM ABC transporter K16786 - - 0.000000000000000000000000000000000000000000000000000000005111 206.0
EH2_k127_2587266_8 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000000007237 190.0
EH2_k127_2587266_9 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000005711 143.0
EH2_k127_2631900_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 416.0
EH2_k127_2631900_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000001434 245.0
EH2_k127_2631900_2 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000000005133 107.0
EH2_k127_2631900_3 - - - - 0.0000000000299 68.0
EH2_k127_2631900_4 - - - - 0.00008235 46.0
EH2_k127_2631900_5 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.0001975 48.0
EH2_k127_2695307_0 Involved in regulation of DNA replication K10725 - - 7.264e-219 685.0
EH2_k127_2695307_1 PFAM Aminotransferase class I and II K10907 - - 2.163e-195 616.0
EH2_k127_2695307_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 557.0
EH2_k127_2695307_3 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 474.0
EH2_k127_2695307_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 347.0
EH2_k127_2695307_5 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000578 250.0
EH2_k127_2695307_6 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000000002302 238.0
EH2_k127_2695307_7 Trm112p-like protein - - - 0.000000000000000227 81.0
EH2_k127_2695307_8 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000001612 50.0
EH2_k127_2713823_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 580.0
EH2_k127_2713823_1 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000805 261.0
EH2_k127_2713823_2 membrane protein domain - - - 0.00000000000000000000000000000000000006203 150.0
EH2_k127_2713823_3 - K03686 - - 0.000000000000000002937 87.0
EH2_k127_2795776_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1258.0
EH2_k127_2795776_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 2.651e-217 680.0
EH2_k127_2795776_10 Protein of unknown function (DUF432) K09149 - - 0.00000000000000000000000000000000000000000000000000006367 194.0
EH2_k127_2795776_11 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000000000000000000000001784 169.0
EH2_k127_2795776_12 - - - - 0.000000000000000000000000000000000000761 147.0
EH2_k127_2795776_13 Protein of unknown function DUF86 K07075 - - 0.0000000000000000000000000004498 122.0
EH2_k127_2795776_14 - - - - 0.00000000000000000001713 95.0
EH2_k127_2795776_15 Histidine kinase-like ATPases - - - 0.0000000000008034 81.0
EH2_k127_2795776_16 metallopeptidase activity - - - 0.00000000002195 70.0
EH2_k127_2795776_2 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 586.0
EH2_k127_2795776_3 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 536.0
EH2_k127_2795776_4 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 473.0
EH2_k127_2795776_5 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 386.0
EH2_k127_2795776_6 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 337.0
EH2_k127_2795776_7 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001092 263.0
EH2_k127_2795776_8 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000000000008284 226.0
EH2_k127_2795776_9 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000000006457 196.0
EH2_k127_2819042_0 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
EH2_k127_2819042_1 COG1202 Superfamily II helicase, archaea-specific - - - 0.0000000000000000000000000000000000000000000000000000000000002647 214.0
EH2_k127_2819042_2 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000008997 214.0
EH2_k127_2819042_3 Voltage gated chloride channel - - - 0.000000000000000000001523 104.0
EH2_k127_2819042_4 - - - - 0.00000000005728 68.0
EH2_k127_3018902_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1503.0
EH2_k127_3018902_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.583e-311 965.0
EH2_k127_3018902_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 598.0
EH2_k127_3018902_3 40-residue YVTN family beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 362.0
EH2_k127_3018902_4 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000003215 264.0
EH2_k127_3018902_5 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000008601 218.0
EH2_k127_3018902_6 peptidase M42 family protein - - - 0.0000000000000001743 79.0
EH2_k127_3018902_7 metallopeptidase activity - - - 0.000241 51.0
EH2_k127_3058403_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1091.0
EH2_k127_3058403_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 5.502e-313 963.0
EH2_k127_3058403_10 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 306.0
EH2_k127_3058403_11 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 290.0
EH2_k127_3058403_12 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004677 275.0
EH2_k127_3058403_13 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002398 266.0
EH2_k127_3058403_14 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000000000000000000003292 236.0
EH2_k127_3058403_15 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000001889 229.0
EH2_k127_3058403_16 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000001283 174.0
EH2_k127_3058403_17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000000007348 139.0
EH2_k127_3058403_18 - - - - 0.0000000000000000000000000000000003237 132.0
EH2_k127_3058403_19 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000000000008971 100.0
EH2_k127_3058403_2 PFAM ferredoxin-dependent glutamate synthase - - - 8.182e-293 907.0
EH2_k127_3058403_20 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000001244 62.0
EH2_k127_3058403_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 524.0
EH2_k127_3058403_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 448.0
EH2_k127_3058403_5 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006287 398.0
EH2_k127_3058403_6 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 396.0
EH2_k127_3058403_7 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 374.0
EH2_k127_3058403_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 355.0
EH2_k127_3058403_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 306.0
EH2_k127_3062858_0 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 345.0
EH2_k127_3062858_1 extracellular matrix structural constituent K01385 - 3.4.23.42 0.000000000000000000000000000000000000000000000000001875 207.0
EH2_k127_3062858_2 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000006582 137.0
EH2_k127_3110035_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.21e-300 930.0
EH2_k127_3110035_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 1.209e-210 673.0
EH2_k127_3110035_11 - - - - 0.00000000898 66.0
EH2_k127_3110035_12 - - - - 0.0000001716 61.0
EH2_k127_3110035_13 - - - - 0.000002905 53.0
EH2_k127_3110035_2 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 307.0
EH2_k127_3110035_3 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 301.0
EH2_k127_3110035_4 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000002356 223.0
EH2_k127_3110035_5 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000000000000000000000000000000004069 220.0
EH2_k127_3110035_6 Flavodoxin - - - 0.000000000000000000000000000000000000000000000000000000105 199.0
EH2_k127_3110035_7 DNA polymerase activity K02319 - 2.7.7.7 0.00000000000000000000000000000000008553 140.0
EH2_k127_3110035_8 Proline dehydrogenase K00318 - - 0.0000000000000000006059 97.0
EH2_k127_3110035_9 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000005504 82.0
EH2_k127_3186252_0 - K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008432 359.0
EH2_k127_3186252_1 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000001015 265.0
EH2_k127_3186252_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000000000000004051 139.0
EH2_k127_3186252_3 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000003 102.0
EH2_k127_3186252_4 - - - - 0.00000000000000001095 90.0
EH2_k127_3186252_5 small multi-drug export - - - 0.0000000000000001424 91.0
EH2_k127_3186252_6 Short repeat of unknown function (DUF308) - - - 0.00007255 53.0
EH2_k127_3190880_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 566.0
EH2_k127_3190880_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 538.0
EH2_k127_3190880_10 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001409 241.0
EH2_k127_3190880_11 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000008784 228.0
EH2_k127_3190880_12 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000003471 181.0
EH2_k127_3190880_13 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000001087 155.0
EH2_k127_3190880_14 Zinc-ribbon containing domain - - - 0.00000000000000000000000000000000002638 135.0
EH2_k127_3190880_15 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000003342 133.0
EH2_k127_3190880_16 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000000009389 110.0
EH2_k127_3190880_17 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.0000000000000009367 78.0
EH2_k127_3190880_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 430.0
EH2_k127_3190880_3 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 382.0
EH2_k127_3190880_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 362.0
EH2_k127_3190880_5 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 353.0
EH2_k127_3190880_6 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 316.0
EH2_k127_3190880_7 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 304.0
EH2_k127_3190880_8 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008783 254.0
EH2_k127_3190880_9 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008018 259.0
EH2_k127_3190959_0 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 597.0
EH2_k127_3190959_1 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 416.0
EH2_k127_3190959_10 - - - - 0.000000000000000000000000000000004676 135.0
EH2_k127_3190959_11 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000001312 121.0
EH2_k127_3190959_12 - K00960 - 2.7.7.6 0.0000000000000000000000000001017 115.0
EH2_k127_3190959_13 - - - - 0.000000000000005172 77.0
EH2_k127_3190959_2 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 383.0
EH2_k127_3190959_3 PFAM amino acid-binding ACT domain protein K06862 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 332.0
EH2_k127_3190959_4 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000001538 263.0
EH2_k127_3190959_5 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000000000000000000000000001798 241.0
EH2_k127_3190959_6 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000004773 194.0
EH2_k127_3190959_7 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000003469 185.0
EH2_k127_3190959_8 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000007927 156.0
EH2_k127_3190959_9 Protein of unknown function (DUF3467) - - - 0.000000000000000000000000000000000000006119 148.0
EH2_k127_3227085_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 8.388e-225 702.0
EH2_k127_3227085_1 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 478.0
EH2_k127_3227085_10 NAD(P)H-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003273 256.0
EH2_k127_3227085_11 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001693 243.0
EH2_k127_3227085_12 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000013 219.0
EH2_k127_3227085_13 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000000000000000000008709 192.0
EH2_k127_3227085_14 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000005272 201.0
EH2_k127_3227085_15 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000002303 185.0
EH2_k127_3227085_16 - - - - 0.000000000000000000000000000000000000000000000006395 177.0
EH2_k127_3227085_17 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000009609 159.0
EH2_k127_3227085_18 CBS domain - - - 0.000000000000000000000000000000001974 134.0
EH2_k127_3227085_19 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000004997 115.0
EH2_k127_3227085_2 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 469.0
EH2_k127_3227085_20 Rubrerythrin - - - 0.00000000000000003745 81.0
EH2_k127_3227085_21 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. K15383 - - 0.000000000005175 69.0
EH2_k127_3227085_3 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 425.0
EH2_k127_3227085_4 PFAM ABC transporter related K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 417.0
EH2_k127_3227085_5 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 388.0
EH2_k127_3227085_6 permease K03299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 369.0
EH2_k127_3227085_7 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 328.0
EH2_k127_3227085_8 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005969 300.0
EH2_k127_3227085_9 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002748 286.0
EH2_k127_3257598_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 5.457e-302 934.0
EH2_k127_3257598_1 Tripartite tricarboxylate transporter TctA family K08971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 386.0
EH2_k127_3257598_10 - - - - 0.00000000000000000000004159 104.0
EH2_k127_3257598_2 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 372.0
EH2_k127_3257598_3 methylase K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006033 368.0
EH2_k127_3257598_4 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 315.0
EH2_k127_3257598_5 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 289.0
EH2_k127_3257598_6 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000008887 265.0
EH2_k127_3257598_7 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004112 258.0
EH2_k127_3257598_8 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002244 250.0
EH2_k127_3257598_9 - - - - 0.00000000000000000000000000000000000000000000000000001154 194.0
EH2_k127_3261899_0 PFAM peptidase U32 K08303 - - 1.67e-202 659.0
EH2_k127_3261899_1 COG0784 FOG CheY-like receiver K01584 - 4.1.1.19 6.332e-199 629.0
EH2_k127_3261899_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 304.0
EH2_k127_3261899_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001269 257.0
EH2_k127_3261899_4 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000305 239.0
EH2_k127_3261899_5 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000005908 182.0
EH2_k127_3261899_6 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.00000000000000000000002972 102.0
EH2_k127_3310745_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0 1008.0
EH2_k127_3310745_1 2Fe-2S iron-sulfur cluster binding domain - - - 1.169e-288 898.0
EH2_k127_3310745_10 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000000000000000000001312 225.0
EH2_k127_3310745_11 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000002055 229.0
EH2_k127_3310745_12 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000004696 208.0
EH2_k127_3310745_13 - - - - 0.0000000000000000000000000000000001959 136.0
EH2_k127_3310745_14 Glutaredoxin - - - 0.0000000000000000000000000000001938 125.0
EH2_k127_3310745_15 - - - - 0.0000000000000000000000132 102.0
EH2_k127_3310745_2 Uncharacterized protein conserved in archaea (DUF2114) - - - 2.539e-260 809.0
EH2_k127_3310745_3 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 2.342e-194 621.0
EH2_k127_3310745_4 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 577.0
EH2_k127_3310745_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 427.0
EH2_k127_3310745_6 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 375.0
EH2_k127_3310745_7 AAA domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 314.0
EH2_k127_3310745_8 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 282.0
EH2_k127_3310745_9 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001248 279.0
EH2_k127_3327148_0 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000004418 242.0
EH2_k127_3327148_1 - - - - 0.000000000000000000000000000000000000004183 151.0
EH2_k127_3327148_2 DGC domain - - - 0.00000000000000000001656 96.0
EH2_k127_3327148_3 - - - - 0.0000000000000005839 82.0
EH2_k127_3327148_4 HTH DNA binding domain - - - 0.00000000007369 71.0
EH2_k127_3349742_0 Belongs to the MCM family K10726 - - 0.0 1093.0
EH2_k127_3349742_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 500.0
EH2_k127_3349742_10 Protein of unknown function (DUF424) K09148 - - 0.00000000000000000000000000005513 118.0
EH2_k127_3349742_11 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.000000000000000001038 97.0
EH2_k127_3349742_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 454.0
EH2_k127_3349742_3 PFAM TatD-related deoxyribonuclease K07049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 359.0
EH2_k127_3349742_4 pfam nmd3 K07562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 345.0
EH2_k127_3349742_5 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 321.0
EH2_k127_3349742_6 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 323.0
EH2_k127_3349742_7 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003162 277.0
EH2_k127_3349742_8 Papain family cysteine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007776 263.0
EH2_k127_3349742_9 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000001802 138.0
EH2_k127_3388148_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 468.0
EH2_k127_3388148_1 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000007515 247.0
EH2_k127_3388148_2 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000133 169.0
EH2_k127_3394114_0 SMART Elongator protein 3 MiaB NifB K22227 - - 2.981e-202 633.0
EH2_k127_3394114_1 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0000000000000000000000000000000000000000000000000000000000000000001472 230.0
EH2_k127_3394114_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000000000000000000000000000000000000000001855 215.0
EH2_k127_3394114_3 sequence-specific DNA binding - - - 0.00000000003316 67.0
EH2_k127_3433630_0 PFAM AMP-dependent synthetase and ligase K00666 - - 2.412e-214 668.0
EH2_k127_3433630_1 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 578.0
EH2_k127_3433630_2 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 496.0
EH2_k127_3433630_3 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 486.0
EH2_k127_3433630_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 291.0
EH2_k127_3433630_5 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007537 271.0
EH2_k127_343808_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 380.0
EH2_k127_343808_1 cellulose binding - - - 0.000000000000000000000000000000001413 148.0
EH2_k127_343808_2 Large-conductance mechanosensitive channel, MscL K03282 - - 0.00000000000000000000000000000001924 128.0
EH2_k127_343808_3 Methyltransferase type 11 - - - 0.000000000000000000000000008232 111.0
EH2_k127_343808_4 GYD domain - - - 0.000000000000000005993 87.0
EH2_k127_343808_5 domain protein K13735 - - 0.00000000001232 78.0
EH2_k127_343808_6 CARDB - - - 0.00001799 57.0
EH2_k127_3456295_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 325.0
EH2_k127_3456295_1 PFAM NADP-dependent oxidoreductase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 299.0
EH2_k127_3456295_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 296.0
EH2_k127_3456295_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000001366 104.0
EH2_k127_3484359_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 556.0
EH2_k127_3484359_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 535.0
EH2_k127_3484359_10 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008479 294.0
EH2_k127_3484359_11 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000002499 215.0
EH2_k127_3484359_12 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000000701 146.0
EH2_k127_3484359_2 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 513.0
EH2_k127_3484359_3 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 436.0
EH2_k127_3484359_4 PFAM Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 425.0
EH2_k127_3484359_5 Domain of unknown function (DUF1743) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 419.0
EH2_k127_3484359_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008322 411.0
EH2_k127_3484359_7 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 362.0
EH2_k127_3484359_8 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 360.0
EH2_k127_3484359_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 345.0
EH2_k127_3502999_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 8.674e-294 908.0
EH2_k127_3502999_1 DEAD DEAH box helicase K06877 - - 8.033e-274 863.0
EH2_k127_3502999_10 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 363.0
EH2_k127_3502999_11 Predicted metal-binding protein (DUF2284) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 348.0
EH2_k127_3502999_12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 341.0
EH2_k127_3502999_13 PFAM Linocin_M18 bacteriocin protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 327.0
EH2_k127_3502999_14 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 319.0
EH2_k127_3502999_15 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 302.0
EH2_k127_3502999_16 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 303.0
EH2_k127_3502999_17 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007002 276.0
EH2_k127_3502999_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004366 261.0
EH2_k127_3502999_19 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000003141 255.0
EH2_k127_3502999_2 N-6 DNA Methylase - - - 1.251e-211 694.0
EH2_k127_3502999_20 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007859 229.0
EH2_k127_3502999_21 Exonuclease K07502 - - 0.000000000000000000000000000000000000000000000000000000000000102 217.0
EH2_k127_3502999_22 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.0000000000000000000000000000000000000000000000000000000003544 204.0
EH2_k127_3502999_23 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000000000000009773 206.0
EH2_k127_3502999_24 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000001525 201.0
EH2_k127_3502999_25 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.000000000000000000000000000000000000000000000000002075 184.0
EH2_k127_3502999_26 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000001682 155.0
EH2_k127_3502999_27 Rubrerythrin - - - 0.000000000000000000000000000000000005328 139.0
EH2_k127_3502999_28 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000000672 138.0
EH2_k127_3502999_29 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000000000000000000000000004785 121.0
EH2_k127_3502999_3 PFAM dihydropteroate synthase, DHPS - - - 8.103e-198 626.0
EH2_k127_3502999_30 Domain of unknown function (DUF1858) - - - 0.00000000000000000000000006265 108.0
EH2_k127_3502999_4 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 605.0
EH2_k127_3502999_5 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 552.0
EH2_k127_3502999_6 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 544.0
EH2_k127_3502999_7 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 456.0
EH2_k127_3502999_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 457.0
EH2_k127_3502999_9 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 402.0
EH2_k127_3513512_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000003566 256.0
EH2_k127_3513512_1 - - - - 0.000000000000000000000000000007392 127.0
EH2_k127_3579913_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1339.0
EH2_k127_3579913_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.361e-307 956.0
EH2_k127_3579913_10 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003683 284.0
EH2_k127_3579913_11 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000004293 263.0
EH2_k127_3579913_12 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009014 243.0
EH2_k127_3579913_13 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000001016 204.0
EH2_k127_3579913_14 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000005887 183.0
EH2_k127_3579913_15 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000003278 164.0
EH2_k127_3579913_16 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000003484 166.0
EH2_k127_3579913_17 Molybdopterin converting factor, small subunit K03636 - - 0.000000000000000000000000000006919 121.0
EH2_k127_3579913_18 - - - - 0.0000000000000000000000001869 119.0
EH2_k127_3579913_19 PEGA domain - - - 0.0000000000000003872 91.0
EH2_k127_3579913_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit K01546 - 3.6.3.12 7.879e-216 683.0
EH2_k127_3579913_3 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 9.938e-215 685.0
EH2_k127_3579913_4 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 434.0
EH2_k127_3579913_5 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 349.0
EH2_k127_3579913_6 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 347.0
EH2_k127_3579913_7 archaeosine synthase activity K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006308 334.0
EH2_k127_3579913_8 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 334.0
EH2_k127_3579913_9 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 306.0
EH2_k127_3627443_0 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 537.0
EH2_k127_3627443_1 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 436.0
EH2_k127_3627443_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 437.0
EH2_k127_3627443_3 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 348.0
EH2_k127_3627443_4 - - - - 0.00000000000000000000000000000000000000001202 161.0
EH2_k127_3627443_5 META domain - - - 0.000000000000000000000000000000000001225 149.0
EH2_k127_3627443_6 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000002073 116.0
EH2_k127_3627443_8 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000001555 66.0
EH2_k127_3640609_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1286.0
EH2_k127_3640609_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 9.111e-290 897.0
EH2_k127_3640609_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 312.0
EH2_k127_3640609_3 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001215 273.0
EH2_k127_3640609_4 protein conserved in archaea K09746 - - 0.0000000000000000000000002002 117.0
EH2_k127_3640609_5 Hep Hag repeat protein - - - 0.00002975 49.0
EH2_k127_3671726_0 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 298.0
EH2_k127_3671726_1 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000041 289.0
EH2_k127_3671726_2 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.0000000000000001071 81.0
EH2_k127_3671726_3 transcriptional regulators K03724 - - 0.0000000000000004256 80.0
EH2_k127_3671726_4 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.0000000000002924 69.0
EH2_k127_3758834_0 Belongs to the glutamate synthase family - - - 1.083e-214 677.0
EH2_k127_3758834_1 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 351.0
EH2_k127_3758834_2 ATP10 protein - - - 0.0000000000000000000000000000000000007377 145.0
EH2_k127_3758834_3 metallopeptidase activity - - - 0.00000000000000000000000001133 120.0
EH2_k127_3850660_0 - - - - 0.000000000000000000000000000000000002047 159.0
EH2_k127_3850660_1 TPR Domain containing protein - - - 0.000000000000000001499 89.0
EH2_k127_3879377_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1187.0
EH2_k127_3879377_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.78e-211 668.0
EH2_k127_3879377_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.037e-208 655.0
EH2_k127_3879377_3 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 346.0
EH2_k127_3879377_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 324.0
EH2_k127_3879377_5 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000003213 188.0
EH2_k127_3879377_6 META domain - - - 0.00000000000000000000000000000000000001072 156.0
EH2_k127_3879377_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000004289 107.0
EH2_k127_398414_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 411.0
EH2_k127_398414_1 membrane protein (DUF2178) - - - 0.000000000000000000000000000000000000000001655 162.0
EH2_k127_3988099_0 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 375.0
EH2_k127_3988099_1 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002313 271.0
EH2_k127_3988099_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003486 248.0
EH2_k127_3988099_3 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000002564 156.0
EH2_k127_3988099_4 - - - - 0.00004131 49.0
EH2_k127_4111991_0 PFAM ABC transporter K00400 - - 8.573e-279 864.0
EH2_k127_4111991_1 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 588.0
EH2_k127_4111991_10 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000003856 114.0
EH2_k127_4111991_11 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000003194 96.0
EH2_k127_4111991_12 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0000000003942 60.0
EH2_k127_4111991_13 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00002681 51.0
EH2_k127_4111991_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 439.0
EH2_k127_4111991_3 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 412.0
EH2_k127_4111991_4 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 396.0
EH2_k127_4111991_5 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 379.0
EH2_k127_4111991_6 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 371.0
EH2_k127_4111991_7 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005304 282.0
EH2_k127_4111991_8 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002122 242.0
EH2_k127_4111991_9 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000000000000002029 215.0
EH2_k127_4149309_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 5.969e-265 821.0
EH2_k127_4149309_1 Phosphate transport regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 504.0
EH2_k127_4149309_10 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000816 224.0
EH2_k127_4149309_11 PFAM transcriptional regulator TrmB - - - 0.00000000000000000000000000000000000000000000000000000000002078 214.0
EH2_k127_4149309_12 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000000000005214 96.0
EH2_k127_4149309_13 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000002679 72.0
EH2_k127_4149309_2 PFAM TrkA-N domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 495.0
EH2_k127_4149309_3 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 467.0
EH2_k127_4149309_4 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 433.0
EH2_k127_4149309_5 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 427.0
EH2_k127_4149309_6 PFAM PP-loop domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 378.0
EH2_k127_4149309_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008211 355.0
EH2_k127_4149309_8 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 342.0
EH2_k127_4149309_9 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 336.0
EH2_k127_4154311_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009552 584.0
EH2_k127_4154311_1 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 461.0
EH2_k127_4154311_2 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 336.0
EH2_k127_4154311_3 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 291.0
EH2_k127_4154311_4 Belongs to the UPF0107 family K09128 - - 0.00000000000000000000000000000000000000000000000000000004459 199.0
EH2_k127_4154311_5 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000002051 198.0
EH2_k127_4154311_6 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000003396 143.0
EH2_k127_4154311_7 - - - - 0.0000000000000000000000000000000005625 136.0
EH2_k127_4154311_8 TIR domain - - - 0.00000000000000004606 86.0
EH2_k127_415578_0 TIGRFAM PAS sensor protein - - - 6.639e-223 732.0
EH2_k127_415578_1 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain K10947 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 511.0
EH2_k127_415578_2 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000001935 121.0
EH2_k127_4179807_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 597.0
EH2_k127_4179807_1 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 312.0
EH2_k127_4179807_2 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 304.0
EH2_k127_4179807_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000004548 211.0
EH2_k127_4179807_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000724 102.0
EH2_k127_4184397_0 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 465.0
EH2_k127_4184397_1 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 312.0
EH2_k127_4184397_2 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000003505 267.0
EH2_k127_4184397_3 - - - - 0.00000000000131 75.0
EH2_k127_4184397_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000006736 65.0
EH2_k127_4198695_0 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 501.0
EH2_k127_4198695_1 CBS domain containing protein K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 491.0
EH2_k127_4198695_10 Small Multidrug Resistance protein K11741 - - 0.000000000000000000000000000000000000000000001854 166.0
EH2_k127_4198695_11 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000000000000000000004194 159.0
EH2_k127_4198695_12 RNA recognition motif - - - 0.0000000000000000000000000000000005344 136.0
EH2_k127_4198695_13 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000001067 136.0
EH2_k127_4198695_14 PFAM Uncharacterised conserved protein UCP006577 - - - 0.000000000000000000000002502 106.0
EH2_k127_4198695_15 SpoVT / AbrB like domain - - - 0.00000000000000000000000491 104.0
EH2_k127_4198695_16 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000000005639 94.0
EH2_k127_4198695_2 HI0933 family K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 461.0
EH2_k127_4198695_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 396.0
EH2_k127_4198695_4 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 385.0
EH2_k127_4198695_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 308.0
EH2_k127_4198695_6 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 303.0
EH2_k127_4198695_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000003186 214.0
EH2_k127_4198695_9 PFAM response regulator receiver K03406 - - 0.0000000000000000000000000000000000000000000000001114 181.0
EH2_k127_4270494_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 610.0
EH2_k127_4270494_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 447.0
EH2_k127_4270494_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 386.0
EH2_k127_4270494_3 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000044 199.0
EH2_k127_4270494_4 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000001382 153.0
EH2_k127_4270494_5 protein conserved in archaea - - - 0.000000000000000000000000000000006323 130.0
EH2_k127_4270494_6 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000002086 115.0
EH2_k127_4270494_7 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000001056 106.0
EH2_k127_4270494_8 - - - - 0.0000000000000145 75.0
EH2_k127_428177_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1158.0
EH2_k127_428177_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1113.0
EH2_k127_428177_2 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 4.508e-210 655.0
EH2_k127_4303322_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 2.937e-251 785.0
EH2_k127_4303322_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.503e-234 737.0
EH2_k127_4303322_10 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 454.0
EH2_k127_4303322_11 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 407.0
EH2_k127_4303322_12 alpha-L-arabinofuranosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 412.0
EH2_k127_4303322_13 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000000003723 229.0
EH2_k127_4303322_14 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000902 216.0
EH2_k127_4303322_15 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000001103 211.0
EH2_k127_4303322_16 ZPR1-related zinc finger protein K06874 - - 0.00000000000000000000000000000000000000000000000000000000001395 211.0
EH2_k127_4303322_17 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000000000345 192.0
EH2_k127_4303322_18 - - - - 0.00000000000000000000000000000000000000000000000000006291 191.0
EH2_k127_4303322_19 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000000000000000000000000000001618 173.0
EH2_k127_4303322_2 DEAD DEAH box helicase K03724 - - 1.775e-233 742.0
EH2_k127_4303322_20 Thioredoxin K03671 - - 0.00000000000000000000000000000000000001149 148.0
EH2_k127_4303322_21 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.0000000000000000000000000000000000004615 142.0
EH2_k127_4303322_22 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000000000009785 143.0
EH2_k127_4303322_23 binds to the 23S rRNA K02922 - - 0.000000000000000000000000025 108.0
EH2_k127_4303322_24 PBS lyase HEAT-like repeat - - - 0.000000000000000000003341 97.0
EH2_k127_4303322_25 Belongs to the UPF0758 family K03630 - - 0.00000000000004976 74.0
EH2_k127_4303322_26 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000001395 75.0
EH2_k127_4303322_27 - - - - 0.00000000296 69.0
EH2_k127_4303322_28 - - - - 0.000000004847 57.0
EH2_k127_4303322_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.47e-229 717.0
EH2_k127_4303322_4 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 7.62e-226 710.0
EH2_k127_4303322_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 1.004e-224 706.0
EH2_k127_4303322_6 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.42e-214 674.0
EH2_k127_4303322_7 N-4 methylation of cytosine K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 514.0
EH2_k127_4303322_8 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 511.0
EH2_k127_4303322_9 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008472 472.0
EH2_k127_4327661_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 4.671e-211 660.0
EH2_k127_4327661_1 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 540.0
EH2_k127_4327661_10 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000001658 157.0
EH2_k127_4327661_11 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000008007 108.0
EH2_k127_4327661_12 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000001129 93.0
EH2_k127_4327661_2 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 429.0
EH2_k127_4327661_3 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 426.0
EH2_k127_4327661_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 415.0
EH2_k127_4327661_5 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 370.0
EH2_k127_4327661_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 334.0
EH2_k127_4327661_7 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000002421 221.0
EH2_k127_4327661_8 LOR SDH bifunctional enzyme conserved - - - 0.0000000000000000000000000000000000000000000000444 171.0
EH2_k127_4327661_9 - - - - 0.00000000000000000000000000000000000000000000006505 172.0
EH2_k127_4338091_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1413.0
EH2_k127_4338091_1 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 4.192e-196 621.0
EH2_k127_4338091_10 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.0000000000000000000000006394 106.0
EH2_k127_4338091_11 Domain of unknown function (DUF4040) - - - 0.0000000000000000000000327 106.0
EH2_k127_4338091_12 Membrane bound hydrogenase - - - 0.0000000000000000002199 92.0
EH2_k127_4338091_2 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 289.0
EH2_k127_4338091_3 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.00000000000000000000000000000000000000000000000000000003233 201.0
EH2_k127_4338091_4 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000001448 201.0
EH2_k127_4338091_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000002351 190.0
EH2_k127_4338091_6 PFAM Na H antiporter MnhB subunit-related protein K05566,K14118 - - 0.00000000000000000000000000000000000000000000005892 173.0
EH2_k127_4338091_7 - - - - 0.00000000000000000000000000000000000001466 156.0
EH2_k127_4338091_8 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.000000000000000000000000000000000002444 141.0
EH2_k127_4338091_9 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000000001 138.0
EH2_k127_4376368_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1313.0
EH2_k127_4376368_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1254.0
EH2_k127_4376368_10 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 299.0
EH2_k127_4376368_11 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000383 275.0
EH2_k127_4376368_12 PFAM regulatory protein, ArsR K07721 - - 0.000000000000000000000000000000000000000000000000000000000002428 214.0
EH2_k127_4376368_13 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000000000000000238 183.0
EH2_k127_4376368_14 - - - - 0.000000000000000000000000000000000000000000000009288 182.0
EH2_k127_4376368_15 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000002252 178.0
EH2_k127_4376368_16 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000003664 173.0
EH2_k127_4376368_17 - - - - 0.000000000000000000000000000000000000000000006654 165.0
EH2_k127_4376368_18 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000000008867 109.0
EH2_k127_4376368_19 Belongs to the small heat shock protein (HSP20) family - - - 0.000000000000001405 83.0
EH2_k127_4376368_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.473e-229 722.0
EH2_k127_4376368_20 PFAM PKD domain containing protein - - - 0.000000000000007388 81.0
EH2_k127_4376368_21 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000004378 57.0
EH2_k127_4376368_3 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 7.11e-202 634.0
EH2_k127_4376368_4 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 550.0
EH2_k127_4376368_5 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 537.0
EH2_k127_4376368_6 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 435.0
EH2_k127_4376368_7 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 419.0
EH2_k127_4376368_8 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 318.0
EH2_k127_4376368_9 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 292.0
EH2_k127_4396238_0 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 496.0
EH2_k127_4396238_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006592 456.0
EH2_k127_4396238_2 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000005683 218.0
EH2_k127_4396238_3 Ribonuclease K03469 - 3.1.26.4 0.0000000000000000000000007222 112.0
EH2_k127_4396238_4 PFAM von Willebrand factor type A - - - 0.00000000000000001536 91.0
EH2_k127_4396238_5 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000001959 78.0
EH2_k127_4425765_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 381.0
EH2_k127_4425765_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008318 297.0
EH2_k127_4425765_10 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000001606 120.0
EH2_k127_4425765_11 Phosphate-starvation-inducible E - - - 0.0000000000000000000000000614 112.0
EH2_k127_4425765_12 PFAM GCN5-related N-acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.00000000000000002282 87.0
EH2_k127_4425765_13 PBS lyase HEAT-like repeat - - - 0.00000004619 60.0
EH2_k127_4425765_14 UV-endonuclease UvdE K13281 - - 0.0003507 45.0
EH2_k127_4425765_2 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000004201 254.0
EH2_k127_4425765_3 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000004237 252.0
EH2_k127_4425765_4 Belongs to the UPF0305 family - - - 0.00000000000000000000000000000000000000000000000000000000000000008018 228.0
EH2_k127_4425765_5 COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II K06897 - 2.5.1.105 0.0000000000000000000000000000000000000000000000000000000000001044 222.0
EH2_k127_4425765_6 Phosphoribosyl transferase domain K07101 - - 0.000000000000000000000000000000000000000000000000000000000002459 216.0
EH2_k127_4425765_7 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000724 210.0
EH2_k127_4425765_8 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000113 171.0
EH2_k127_4425765_9 double-stranded RNA binding K03685 - 3.1.26.3 0.000000000000000000000000000000000000003025 156.0
EH2_k127_4428977_0 PFAM Radical SAM domain protein K06937 - - 1.578e-248 774.0
EH2_k127_4428977_1 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 9.58e-237 751.0
EH2_k127_4428977_10 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000009053 153.0
EH2_k127_4428977_11 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000000003743 107.0
EH2_k127_4428977_2 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 602.0
EH2_k127_4428977_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 544.0
EH2_k127_4428977_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009761 479.0
EH2_k127_4428977_5 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 427.0
EH2_k127_4428977_6 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006859 427.0
EH2_k127_4428977_7 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004982 353.0
EH2_k127_4428977_8 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.0000000000000000000000000000000000000000000000000000000001779 208.0
EH2_k127_4428977_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000004219 178.0
EH2_k127_4440099_0 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 368.0
EH2_k127_4440099_1 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 362.0
EH2_k127_4440099_2 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 317.0
EH2_k127_4440099_3 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 315.0
EH2_k127_4440099_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000005795 219.0
EH2_k127_4440099_5 PFAM Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000000001906 213.0
EH2_k127_4440099_6 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000008447 169.0
EH2_k127_4440099_7 - - - - 0.000000000000000000000000000000000006395 143.0
EH2_k127_447546_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 1.485e-272 842.0
EH2_k127_447546_1 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 2.394e-231 724.0
EH2_k127_447546_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 484.0
EH2_k127_447546_3 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 405.0
EH2_k127_448219_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 8.539e-252 781.0
EH2_k127_448219_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.76e-251 790.0
EH2_k127_448219_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 421.0
EH2_k127_448219_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 316.0
EH2_k127_448219_4 PFAM ABC-1 domain protein K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 310.0
EH2_k127_4496318_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1135.0
EH2_k127_4496318_1 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 541.0
EH2_k127_4496318_2 ATP-grasp domain K06914 - 6.3.4.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 414.0
EH2_k127_4496318_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 404.0
EH2_k127_4496318_4 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 361.0
EH2_k127_4496318_5 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 335.0
EH2_k127_4496318_6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000336 271.0
EH2_k127_4496318_7 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000000000000000002528 176.0
EH2_k127_4496318_8 - - - - 0.00000000000000000000000000000000000000000000678 168.0
EH2_k127_4496318_9 - - - - 0.00000000000000001934 87.0
EH2_k127_4516985_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 6.877e-246 771.0
EH2_k127_4516985_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000008206 117.0
EH2_k127_4516985_2 Protein of unknown function (DUF2764) - - - 0.00003115 53.0
EH2_k127_4539383_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 435.0
EH2_k127_4539383_1 CorA-like Mg2+ transporter protein K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 419.0
EH2_k127_4539383_2 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 389.0
EH2_k127_4539383_3 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000005276 232.0
EH2_k127_4539383_4 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000003936 218.0
EH2_k127_456936_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 580.0
EH2_k127_456936_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009308 498.0
EH2_k127_456936_2 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000004367 169.0
EH2_k127_456936_3 PFAM PKD domain containing protein - - - 0.00000000000000003005 91.0
EH2_k127_4627775_0 PFAM type II secretion system protein E K07332 - - 3.423e-290 902.0
EH2_k127_4627775_1 type II secretion system protein K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 600.0
EH2_k127_4627775_2 KaiC K07331 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 314.0
EH2_k127_4627775_3 Archaeal flagellar protein F K07329 - - 0.000000000000000006384 89.0
EH2_k127_47604_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 462.0
EH2_k127_47604_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 388.0
EH2_k127_47604_2 DGC domain - - - 0.000000000000000000000000000000000002696 142.0
EH2_k127_47604_3 PFAM regulatory protein, ArsR K21903 - - 0.000000000000000000000000000000002558 132.0
EH2_k127_47604_4 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000000000000000001885 120.0
EH2_k127_47604_5 - - - - 0.000000000000000000000000004045 114.0
EH2_k127_47604_6 Cupin 2 conserved barrel domain - - - 0.000000000000000000000004708 104.0
EH2_k127_4797381_0 Belongs to the glutamate synthase family - - - 5.484e-275 851.0
EH2_k127_4797381_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 9.122e-229 715.0
EH2_k127_4797381_2 PFAM glutamine amidotransferase, class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 553.0
EH2_k127_4797381_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 424.0
EH2_k127_4797381_4 PFAM glutamate synthase alpha subunit domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 359.0
EH2_k127_4865060_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.378e-257 799.0
EH2_k127_4865060_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 588.0
EH2_k127_4865060_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 498.0
EH2_k127_4865060_3 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000001768 152.0
EH2_k127_4865060_4 PFAM metallophosphoesterase - - - 0.00000000000007081 82.0
EH2_k127_5032920_0 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 563.0
EH2_k127_5032920_1 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 316.0
EH2_k127_5032920_2 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 300.0
EH2_k127_5032920_3 Zinc-uptake complex component A periplasmic K09815 - - 0.00000000000000000000000000000000000000000000000000000000000000003555 234.0
EH2_k127_5032920_4 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000001401 203.0
EH2_k127_5032920_5 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000002357 166.0
EH2_k127_5032920_6 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000149 79.0
EH2_k127_5064660_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 422.0
EH2_k127_5064660_1 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 374.0
EH2_k127_5064660_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 301.0
EH2_k127_5162740_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 443.0
EH2_k127_5162740_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009243 373.0
EH2_k127_5162740_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008185 329.0
EH2_k127_5162740_3 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000001256 214.0
EH2_k127_5171541_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 2.998e-241 754.0
EH2_k127_5171541_1 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 451.0
EH2_k127_5171541_2 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 313.0
EH2_k127_5171541_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000002602 232.0
EH2_k127_5171541_4 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000008288 218.0
EH2_k127_5171541_5 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000001783 186.0
EH2_k127_5188308_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 7.729e-296 915.0
EH2_k127_5188308_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 2.855e-259 803.0
EH2_k127_5188308_10 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000003387 169.0
EH2_k127_5188308_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000001678 145.0
EH2_k127_5188308_12 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000002947 137.0
EH2_k127_5188308_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000001346 122.0
EH2_k127_5188308_14 ATP synthase subunit C K02124 - - 0.00000000000000000001024 93.0
EH2_k127_5188308_16 cell adhesion involved in biofilm formation - - - 0.000000000000007679 89.0
EH2_k127_5188308_2 V-type ATPase 116kDa subunit family K02123 - - 9.41e-203 649.0
EH2_k127_5188308_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 370.0
EH2_k127_5188308_4 V-type ATP synthase, subunit I K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 323.0
EH2_k127_5188308_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 305.0
EH2_k127_5188308_6 FHA domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005227 284.0
EH2_k127_5188308_7 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000129 304.0
EH2_k127_5188308_8 ATP synthase subunit K K02124 - - 0.0000000000000000000000000000000000000000000002747 171.0
EH2_k127_5188308_9 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000002152 174.0
EH2_k127_5294682_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 481.0
EH2_k127_5294682_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 355.0
EH2_k127_5294682_2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 304.0
EH2_k127_5294682_3 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000000000000000000000000000000000000004097 240.0
EH2_k127_5294682_4 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000003373 226.0
EH2_k127_5294682_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001226 210.0
EH2_k127_5294682_6 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000009605 105.0
EH2_k127_5294682_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000001443 96.0
EH2_k127_5307746_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1156.0
EH2_k127_5307746_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 3.96e-260 814.0
EH2_k127_5307746_2 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 446.0
EH2_k127_5307746_3 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 400.0
EH2_k127_5307746_4 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000005491 235.0
EH2_k127_5307746_5 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000002259 123.0
EH2_k127_5307746_6 methyltransferase small K07579 - - 0.00000000000000000004628 90.0
EH2_k127_5436172_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 1.895e-208 661.0
EH2_k127_5436172_1 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 4.238e-196 621.0
EH2_k127_5436172_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007257 226.0
EH2_k127_5436172_11 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000003791 224.0
EH2_k127_5436172_12 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000001431 119.0
EH2_k127_5436172_13 structural constituent of ribosome K02962 - - 0.000000000000000000001316 95.0
EH2_k127_5436172_14 - - - - 0.000001436 53.0
EH2_k127_5436172_2 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 572.0
EH2_k127_5436172_3 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 453.0
EH2_k127_5436172_4 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 448.0
EH2_k127_5436172_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 436.0
EH2_k127_5436172_6 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 391.0
EH2_k127_5436172_7 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 364.0
EH2_k127_5436172_8 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006677 353.0
EH2_k127_5436172_9 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000005576 260.0
EH2_k127_5450468_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 435.0
EH2_k127_5450468_1 COG2513 PEP phosphonomutase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 327.0
EH2_k127_5450468_2 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000000000000000000000001433 141.0
EH2_k127_5455639_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 2.834e-195 614.0
EH2_k127_5455639_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 501.0
EH2_k127_5455639_2 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 413.0
EH2_k127_5455639_3 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 285.0
EH2_k127_5455639_4 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000001545 185.0
EH2_k127_5455639_5 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000006891 152.0
EH2_k127_5542412_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.477e-240 769.0
EH2_k127_5542412_1 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000004545 185.0
EH2_k127_5542412_2 - - - - 0.000000000000009297 77.0
EH2_k127_5629247_0 PhoU domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 423.0
EH2_k127_5629247_1 Thioredoxin - - - 0.00000000000000000000000000000000000000000002287 165.0
EH2_k127_5629247_2 CARDB - - - 0.0000000000000000000000001943 117.0
EH2_k127_5629247_3 PBP superfamily domain K02040 - - 0.0000000007493 62.0
EH2_k127_564700_0 acid binding OB-fold tRNA helicase-type K07463 - - 1.462e-307 953.0
EH2_k127_564700_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.239e-295 926.0
EH2_k127_564700_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000003064 218.0
EH2_k127_564700_11 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000004496 211.0
EH2_k127_564700_12 adenyl ribonucleotide binding - - - 0.000000000000000000000000000000000000000000000002239 179.0
EH2_k127_564700_13 TfuA-like protein - - - 0.00000000000000000000000000000000000000009727 160.0
EH2_k127_564700_14 - - - - 0.0000000000000000000000000000000003189 133.0
EH2_k127_564700_15 - - - - 0.0000000000000000000001428 98.0
EH2_k127_564700_16 PFAM Yip1 domain - - - 0.000000000000003702 83.0
EH2_k127_564700_17 Hsp20/alpha crystallin family K13993 - - 0.0000003863 57.0
EH2_k127_564700_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 2.981e-247 766.0
EH2_k127_564700_3 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 545.0
EH2_k127_564700_4 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 526.0
EH2_k127_564700_5 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 449.0
EH2_k127_564700_6 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 371.0
EH2_k127_564700_7 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 363.0
EH2_k127_564700_8 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 337.0
EH2_k127_564700_9 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000001118 250.0
EH2_k127_5750895_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 591.0
EH2_k127_5750895_1 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 469.0
EH2_k127_5750895_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 393.0
EH2_k127_5750895_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001962 251.0
EH2_k127_5902306_0 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 394.0
EH2_k127_5902306_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000404 247.0
EH2_k127_5902306_10 - - - - 0.000000000003663 67.0
EH2_k127_5902306_11 - - - - 0.000004131 53.0
EH2_k127_5902306_2 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000004809 230.0
EH2_k127_5902306_3 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.000000000000000000000000000000000000000000000000000000000001533 212.0
EH2_k127_5902306_4 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000468 215.0
EH2_k127_5902306_5 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000000002474 156.0
EH2_k127_5902306_6 Hydrogenase maturation protease K08315 - 3.4.23.51 0.000000000000000000000000000000000000000398 154.0
EH2_k127_5902306_7 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000000001434 158.0
EH2_k127_5902306_8 - - - - 0.00000000000000000013 94.0
EH2_k127_5902306_9 META domain - - - 0.000000000000000000986 91.0
EH2_k127_6009602_0 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 422.0
EH2_k127_6009602_1 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 357.0
EH2_k127_6009602_2 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002036 285.0
EH2_k127_6009602_3 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000004551 264.0
EH2_k127_6009602_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000007169 145.0
EH2_k127_6122199_0 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 561.0
EH2_k127_6122199_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 467.0
EH2_k127_6122199_10 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000000001823 171.0
EH2_k127_6122199_11 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000000189 147.0
EH2_k127_6122199_12 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000000042 141.0
EH2_k127_6122199_13 - - - - 0.0000000000000000000000000000000001259 141.0
EH2_k127_6122199_14 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000001299 130.0
EH2_k127_6122199_15 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000000000008238 128.0
EH2_k127_6122199_16 CRS1_YhbY K07574 - - 0.000000000000000000000001351 104.0
EH2_k127_6122199_17 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000000006605 99.0
EH2_k127_6122199_18 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000001125 86.0
EH2_k127_6122199_19 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000003218 87.0
EH2_k127_6122199_2 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 447.0
EH2_k127_6122199_20 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000389 53.0
EH2_k127_6122199_3 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 327.0
EH2_k127_6122199_4 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 291.0
EH2_k127_6122199_5 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007779 275.0
EH2_k127_6122199_6 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000000000000000000000000000000000000000000000000003523 234.0
EH2_k127_6122199_7 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000000000000008714 230.0
EH2_k127_6122199_8 archaeal Zn-finger protein - - - 0.0000000000000000000000000000000000000000000000000000000001203 211.0
EH2_k127_6122199_9 Domain of unknown function (DUF371) K09738 - - 0.000000000000000000000000000000000000000000000000008635 184.0
EH2_k127_6171517_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.103e-234 733.0
EH2_k127_6171517_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 528.0
EH2_k127_6171517_10 PFAM Phosphomethylpyrimidine kinase K00941,K21219,K21220 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000004739 52.0
EH2_k127_6171517_2 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 335.0
EH2_k127_6171517_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 316.0
EH2_k127_6171517_4 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000000000000000000000000000000000002699 194.0
EH2_k127_6171517_5 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000000000000000000000000006471 181.0
EH2_k127_6171517_6 - - - - 0.000000000000000000000000000000000000000000000001595 180.0
EH2_k127_6171517_7 PFAM HEPN domain - - - 0.00000000000000000000000000000000000000236 150.0
EH2_k127_6171517_8 Nucleotidyltransferase domain K07076 - - 0.0000000000000000000000000002254 117.0
EH2_k127_6171517_9 ADP-ribosylglycohydrolase - - - 0.000000000001055 69.0
EH2_k127_6180960_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000006349 234.0
EH2_k127_6180960_1 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000002534 150.0
EH2_k127_6180960_2 Parallel beta-helix repeats - - - 0.000000000000000000000000000278 132.0
EH2_k127_6180960_3 Cytotoxic translational repressor of toxin-antitoxin stability system K06218 - - 0.00000000000000000002416 93.0
EH2_k127_6180960_4 TPR Domain containing protein - - - 0.000000000000000001093 89.0
EH2_k127_6180960_5 - - - - 0.000000000000003221 81.0
EH2_k127_6180960_6 - - - - 0.00000000000007745 74.0
EH2_k127_6216785_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.407e-255 793.0
EH2_k127_6216785_1 AMP-binding enzyme - - - 1.342e-208 656.0
EH2_k127_6216785_10 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00580 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 402.0
EH2_k127_6216785_11 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 387.0
EH2_k127_6216785_12 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 375.0
EH2_k127_6216785_13 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 369.0
EH2_k127_6216785_14 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 358.0
EH2_k127_6216785_15 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 360.0
EH2_k127_6216785_16 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 353.0
EH2_k127_6216785_17 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 309.0
EH2_k127_6216785_18 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001147 275.0
EH2_k127_6216785_19 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000686 272.0
EH2_k127_6216785_2 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 2.254e-204 638.0
EH2_k127_6216785_20 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006251 264.0
EH2_k127_6216785_21 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005131 256.0
EH2_k127_6216785_22 Oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006693 255.0
EH2_k127_6216785_23 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001555 246.0
EH2_k127_6216785_24 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008956 242.0
EH2_k127_6216785_25 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004103 243.0
EH2_k127_6216785_26 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004269 239.0
EH2_k127_6216785_27 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000000011 235.0
EH2_k127_6216785_28 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000002743 228.0
EH2_k127_6216785_29 binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000000000269 223.0
EH2_k127_6216785_3 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 590.0
EH2_k127_6216785_30 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000002236 222.0
EH2_k127_6216785_31 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000005559 215.0
EH2_k127_6216785_32 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000000000000000000000006532 222.0
EH2_k127_6216785_33 PFAM sigma-70 region 4 domain protein K09714 - - 0.0000000000000000000000000000000000000000000000000000000000004898 213.0
EH2_k127_6216785_34 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000007598 195.0
EH2_k127_6216785_35 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000000000000000000004743 189.0
EH2_k127_6216785_36 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000000002646 176.0
EH2_k127_6216785_37 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.0000000000000000000000000000000000000000000000431 169.0
EH2_k127_6216785_38 PFAM Ribosomal protein K02912 - - 0.00000000000000000000000000000000000000000000133 169.0
EH2_k127_6216785_39 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000000000000000002578 162.0
EH2_k127_6216785_4 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 539.0
EH2_k127_6216785_40 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00578 - 2.1.1.86 0.00000000000000000000000000000000001301 138.0
EH2_k127_6216785_41 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.000000000000000000000000002373 114.0
EH2_k127_6216785_42 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000000008765 107.0
EH2_k127_6216785_43 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.0000000000000000000000001653 106.0
EH2_k127_6216785_44 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.0000000000000000000000002407 110.0
EH2_k127_6216785_45 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000000000000003525 108.0
EH2_k127_6216785_46 TIGRFAM tetrahydromethanopterin S-methyltransferase, F subunit K00582 - 2.1.1.86 0.000000000000000000004683 93.0
EH2_k127_6216785_47 - - - - 0.0000002997 55.0
EH2_k127_6216785_5 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 481.0
EH2_k127_6216785_6 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 417.0
EH2_k127_6216785_7 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00579 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 413.0
EH2_k127_6216785_8 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 410.0
EH2_k127_6216785_9 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 401.0
EH2_k127_62539_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1217.0
EH2_k127_62539_1 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 1.275e-321 1015.0
EH2_k127_62539_10 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000001543 181.0
EH2_k127_62539_11 - - - - 0.000000000000000000000000000002117 122.0
EH2_k127_62539_12 PFAM plasmid stabilization system K06218 - - 0.000000000000000000000000002211 113.0
EH2_k127_62539_13 - - - - 0.00000000000000002852 92.0
EH2_k127_62539_14 - - - - 0.0000000000001004 77.0
EH2_k127_62539_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.793e-295 920.0
EH2_k127_62539_3 COG0477 Permeases of the major facilitator superfamily K08177 - - 9.662e-197 620.0
EH2_k127_62539_4 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 569.0
EH2_k127_62539_5 PFAM glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 525.0
EH2_k127_62539_6 Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor K00918 - 2.7.1.146,2.7.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 481.0
EH2_k127_62539_7 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 317.0
EH2_k127_62539_8 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 301.0
EH2_k127_62539_9 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000003075 271.0
EH2_k127_6258790_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1350.0
EH2_k127_6258790_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 4.224e-209 655.0
EH2_k127_6258790_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 396.0
EH2_k127_6258790_3 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001757 278.0
EH2_k127_6258790_4 chromosome segregation and condensation protein ScpA K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007765 244.0
EH2_k127_6258790_5 TIGRFAM F420-dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000001319 172.0
EH2_k127_6258790_6 - - - - 0.00000000000000000000001479 107.0
EH2_k127_6262112_0 Ferrous iron transport B domain protein K04759 - - 5.834e-223 707.0
EH2_k127_6262112_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 9.315e-211 671.0
EH2_k127_6262112_10 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000000000000000000000000000000001399 214.0
EH2_k127_6262112_11 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000002394 208.0
EH2_k127_6262112_12 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000006912 164.0
EH2_k127_6262112_13 iron dependent repressor K03709,K04758 - - 0.0000000000000000000000000000000000000001014 159.0
EH2_k127_6262112_14 Protein of unknown function (DUF357) K09728 - - 0.00000000000000000000000000000002079 133.0
EH2_k127_6262112_15 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000003982 126.0
EH2_k127_6262112_16 Isocitrate/isopropylmalate dehydrogenase K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 0.000000000001762 70.0
EH2_k127_6262112_2 Helix-hairpin-helix domain K02347 - - 1.573e-196 627.0
EH2_k127_6262112_3 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 412.0
EH2_k127_6262112_4 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 404.0
EH2_k127_6262112_5 Papain family cysteine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 413.0
EH2_k127_6262112_6 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 349.0
EH2_k127_6262112_7 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 342.0
EH2_k127_6262112_8 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000001151 246.0
EH2_k127_6262112_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000004952 222.0
EH2_k127_6350769_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 5.561e-277 868.0
EH2_k127_6350769_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 502.0
EH2_k127_6350769_10 - K06193 - - 0.000000001582 59.0
EH2_k127_6350769_2 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 437.0
EH2_k127_6350769_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005785 273.0
EH2_k127_6350769_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000006924 253.0
EH2_k127_6350769_5 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000001415 188.0
EH2_k127_6350769_6 Calcineurin-like phosphoesterase superfamily domain K01090 - 3.1.3.16 0.000000000000000000000000000000000000000000000007998 184.0
EH2_k127_6350769_7 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000604 177.0
EH2_k127_6350769_8 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000001177 166.0
EH2_k127_6350769_9 - - - - 0.0000000000000003082 83.0
EH2_k127_6360520_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.0 1023.0
EH2_k127_6360520_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 530.0
EH2_k127_6360520_2 PFAM CBS domain containing protein - - - 0.00000001019 57.0
EH2_k127_6360520_3 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000003239 54.0
EH2_k127_6381498_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 605.0
EH2_k127_6381498_1 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 576.0
EH2_k127_6381498_10 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007448 400.0
EH2_k127_6381498_11 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 374.0
EH2_k127_6381498_12 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 352.0
EH2_k127_6381498_13 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005743 288.0
EH2_k127_6381498_14 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000007675 219.0
EH2_k127_6381498_15 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.00000000000000000000000000000000000000000000000000000000001507 214.0
EH2_k127_6381498_16 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000000000000000000000000003516 190.0
EH2_k127_6381498_17 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000000000000000000000000006832 186.0
EH2_k127_6381498_18 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000000000000000000001333 165.0
EH2_k127_6381498_19 Belongs to the NifD NifK NifE NifN family K02587 - - 0.0000000000000000000000000002325 128.0
EH2_k127_6381498_2 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 539.0
EH2_k127_6381498_20 - - - - 0.00000000000000000000000009825 111.0
EH2_k127_6381498_3 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 525.0
EH2_k127_6381498_4 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 516.0
EH2_k127_6381498_5 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 518.0
EH2_k127_6381498_6 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004113 509.0
EH2_k127_6381498_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 491.0
EH2_k127_6381498_8 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 475.0
EH2_k127_6381498_9 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 431.0
EH2_k127_6409608_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001832 266.0
EH2_k127_6409608_1 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000399 256.0
EH2_k127_6409608_2 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000008839 193.0
EH2_k127_6409608_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000007587 182.0
EH2_k127_6409608_4 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.000000000000000000000000000000000000000000000000165 183.0
EH2_k127_6409608_5 - - - - 0.0000000000000000000004817 99.0
EH2_k127_6483689_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 577.0
EH2_k127_6483689_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 402.0
EH2_k127_6483689_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000003227 241.0
EH2_k127_6483689_3 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000002469 199.0
EH2_k127_6488797_0 Protein of unknown function (DUF460) K09150 - - 1.597e-254 802.0
EH2_k127_6488797_1 Rio2, N-terminal K07179 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008873 328.0
EH2_k127_6488797_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 315.0
EH2_k127_6488797_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000256 271.0
EH2_k127_6517480_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 1.201e-294 911.0
EH2_k127_6517480_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.055e-258 802.0
EH2_k127_6517480_2 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 6.532e-239 741.0
EH2_k127_6517480_3 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 387.0
EH2_k127_6517480_4 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000001272 175.0
EH2_k127_6563810_0 phosphoesterase RecJ domain protein - - - 4.922e-196 622.0
EH2_k127_6563810_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 460.0
EH2_k127_6563810_2 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004696 280.0
EH2_k127_6563810_3 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002225 298.0
EH2_k127_659342_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 3.555e-200 629.0
EH2_k127_659342_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 439.0
EH2_k127_659342_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 433.0
EH2_k127_659342_3 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000000000002302 183.0
EH2_k127_659342_4 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000003301 74.0
EH2_k127_6615172_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 7.119e-259 811.0
EH2_k127_6615172_1 Predicted membrane protein (DUF2070) K08979 - - 2.116e-205 654.0
EH2_k127_6615172_10 Pas domain - - - 0.000000000000000000000000000000000000000095 174.0
EH2_k127_6615172_11 Family of unknown function (DUF5350) - - - 0.0000000000000000000000007042 107.0
EH2_k127_6615172_12 - - - - 0.0000000000000000000000993 101.0
EH2_k127_6615172_2 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 559.0
EH2_k127_6615172_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 535.0
EH2_k127_6615172_4 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 373.0
EH2_k127_6615172_5 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 283.0
EH2_k127_6615172_6 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000006453 239.0
EH2_k127_6615172_7 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000003238 205.0
EH2_k127_6615172_8 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000000000000000000002725 192.0
EH2_k127_6615172_9 Pas domain - - - 0.000000000000000000000000000000000000000000000000000006656 216.0
EH2_k127_6681767_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 511.0
EH2_k127_6681767_1 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 389.0
EH2_k127_6681767_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000008203 232.0
EH2_k127_6681767_4 Methyltransferase domain - - - 0.00000000000000000000000000000000292 130.0
EH2_k127_6681767_5 Methyltransferase domain - - - 0.00000000000000001822 86.0
EH2_k127_6686765_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009076 459.0
EH2_k127_6686765_1 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 348.0
EH2_k127_6686765_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.000000000000000001224 86.0
EH2_k127_6686765_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000004378 57.0
EH2_k127_6692423_0 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 471.0
EH2_k127_6692423_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 347.0
EH2_k127_6692423_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 329.0
EH2_k127_6692423_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 331.0
EH2_k127_6692423_4 PFAM YHS domain - - - 0.0000000000005036 74.0
EH2_k127_6692423_5 - - - - 0.000000000001367 74.0
EH2_k127_6692423_6 PFAM Bacterial protein of - - - 0.00000000002237 69.0
EH2_k127_6692423_8 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000001964 59.0
EH2_k127_6716609_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.251e-248 773.0
EH2_k127_6716609_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 2.123e-202 641.0
EH2_k127_6716609_10 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000000000000000000000000002967 154.0
EH2_k127_6716609_11 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000000000003759 151.0
EH2_k127_6716609_12 Contacts the emerging nascent chain on the ribosome K03626 - - 0.00000000000000000000000000000000000001004 147.0
EH2_k127_6716609_13 HEAT repeats - - - 0.0000000000000000000000000000000007857 138.0
EH2_k127_6716609_14 Cna B domain protein - - - 0.00000000000000000000003085 116.0
EH2_k127_6716609_15 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000003462 89.0
EH2_k127_6716609_16 PFAM PUA domain K07398 - - 0.0000000000000000001019 98.0
EH2_k127_6716609_17 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000000007252 97.0
EH2_k127_6716609_18 Probably involved in the biogenesis of the ribosome K14561 - - 0.000000000000000001655 91.0
EH2_k127_6716609_19 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000006325 85.0
EH2_k127_6716609_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 559.0
EH2_k127_6716609_20 PhoD-like phosphatase K01113 - 3.1.3.1 0.00000000000000002073 93.0
EH2_k127_6716609_21 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000001081 94.0
EH2_k127_6716609_22 PBS lyase HEAT-like repeat - - - 0.000000000001378 72.0
EH2_k127_6716609_23 PhoD-like phosphatase K01113 - 3.1.3.1 0.00000000000224 75.0
EH2_k127_6716609_24 SMART Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000006166 72.0
EH2_k127_6716609_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 414.0
EH2_k127_6716609_4 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 363.0
EH2_k127_6716609_5 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 334.0
EH2_k127_6716609_6 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 321.0
EH2_k127_6716609_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000002406 209.0
EH2_k127_6716609_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000000000000000000000000000000000000000000000001453 190.0
EH2_k127_6716609_9 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000003435 156.0
EH2_k127_6780496_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 7.442e-310 968.0
EH2_k127_6780496_1 AAA-like domain K06915 - - 1.03e-283 879.0
EH2_k127_6780496_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 3.809e-198 622.0
EH2_k127_6780496_3 Glycosyltransferase 28 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 445.0
EH2_k127_678914_0 Domain of unknown function (DUF389) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 316.0
EH2_k127_678914_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 295.0
EH2_k127_678914_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
EH2_k127_678914_3 PFAM PKD domain containing protein - - - 0.000000000000000004819 95.0
EH2_k127_678914_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000001607 66.0
EH2_k127_6801771_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 4.972e-199 628.0
EH2_k127_6801771_1 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 2.551e-198 632.0
EH2_k127_6801771_10 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000006686 228.0
EH2_k127_6801771_11 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000006386 225.0
EH2_k127_6801771_12 PFAM TPR repeat-containing protein - - - 0.0000000000000000004632 95.0
EH2_k127_6801771_2 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 566.0
EH2_k127_6801771_3 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 448.0
EH2_k127_6801771_4 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 448.0
EH2_k127_6801771_5 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 415.0
EH2_k127_6801771_6 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 381.0
EH2_k127_6801771_7 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 292.0
EH2_k127_6801771_8 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004254 273.0
EH2_k127_6801771_9 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000000000000000000000003922 232.0
EH2_k127_6822580_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 581.0
EH2_k127_6822580_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 476.0
EH2_k127_6822580_2 - - - - 0.000000000000000000000000000000000000000001167 166.0
EH2_k127_6884298_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1036.0
EH2_k127_6884298_1 DEAD DEAH box helicase domain protein K03725 - - 1.567e-294 917.0
EH2_k127_6884298_10 PFAM NHL repeat containing protein - - - 0.0000000000000000000213 94.0
EH2_k127_6884298_2 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 3.628e-237 737.0
EH2_k127_6884298_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 554.0
EH2_k127_6884298_4 SMART regulatory protein, Crp K07730 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 421.0
EH2_k127_6884298_5 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 282.0
EH2_k127_6884298_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001757 280.0
EH2_k127_6884298_7 - - - - 0.00000000000000000000000000000000000000000000000000001946 215.0
EH2_k127_6884298_8 ArsR transcriptional regulator - - - 0.00000000000000000000000000000000000000000001602 167.0
EH2_k127_6884298_9 membrane K09167 - - 0.0000000000000000000000000000000005244 141.0
EH2_k127_6904179_0 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000008526 246.0
EH2_k127_6904179_1 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.00000000003487 78.0
EH2_k127_6906649_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1622.0
EH2_k127_6906649_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1405.0
EH2_k127_6906649_10 COG1403 Restriction endonuclease K10726 - - 0.00000000000000000000000000000000004891 138.0
EH2_k127_6906649_11 - - - - 0.0000000000000000000000000000000002802 134.0
EH2_k127_6906649_2 PFAM PilT protein domain protein K06865 - - 4.262e-301 933.0
EH2_k127_6906649_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 3.05e-251 777.0
EH2_k127_6906649_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 1.16e-211 662.0
EH2_k127_6906649_5 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 357.0
EH2_k127_6906649_6 transcription termination protein NusA K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005907 239.0
EH2_k127_6906649_7 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.0000000000000000000000000000000000000000001727 160.0
EH2_k127_6906649_8 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000000000000000000000005376 160.0
EH2_k127_6906649_9 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000001001 148.0
EH2_k127_6916746_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 595.0
EH2_k127_6916746_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 298.0
EH2_k127_6963638_0 PFAM type II secretion system protein E K07332 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 447.0
EH2_k127_6963638_1 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 345.0
EH2_k127_6963638_2 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000006551 184.0
EH2_k127_714290_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 551.0
EH2_k127_714290_1 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 349.0
EH2_k127_714290_2 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 286.0
EH2_k127_714290_3 Domain of unknown function (DUF1858) - - - 0.00000000000000000000000003323 108.0
EH2_k127_7153369_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 517.0
EH2_k127_7153369_1 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 504.0
EH2_k127_7153369_2 methanogen marker protein 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 302.0
EH2_k127_7153369_3 PFAM peptidase zinc-dependent K06974 - - 0.000000000000000000000000000000000000000000000000000001284 198.0
EH2_k127_7153369_4 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000000411 156.0
EH2_k127_7153369_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000000002465 131.0
EH2_k127_718863_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 575.0
EH2_k127_718863_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 386.0
EH2_k127_718863_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 356.0
EH2_k127_718863_3 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000007906 135.0
EH2_k127_7225802_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 3.982e-294 912.0
EH2_k127_7225802_1 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 2.691e-283 883.0
EH2_k127_7225802_10 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 309.0
EH2_k127_7225802_11 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 312.0
EH2_k127_7225802_12 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 301.0
EH2_k127_7225802_13 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001912 271.0
EH2_k127_7225802_14 amino acid K16263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000636 272.0
EH2_k127_7225802_15 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009494 256.0
EH2_k127_7225802_16 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K14107 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007549 254.0
EH2_k127_7225802_17 - K14093 - - 0.000000000000000000000000000000000000000000000000000000000000000000006222 238.0
EH2_k127_7225802_18 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000001296 212.0
EH2_k127_7225802_19 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000207 207.0
EH2_k127_7225802_2 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 6.861e-213 668.0
EH2_k127_7225802_20 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000004266 204.0
EH2_k127_7225802_21 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000000000000000005433 194.0
EH2_k127_7225802_22 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000003601 198.0
EH2_k127_7225802_23 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.000000000000000000000000000000000000000000000000006186 185.0
EH2_k127_7225802_24 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.00000000000000000000000000000000000000000000000001525 184.0
EH2_k127_7225802_25 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.00000000000000000000000000000000000000000004217 166.0
EH2_k127_7225802_26 - - - - 0.000000000000000000000000000000000000000004424 166.0
EH2_k127_7225802_27 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000001626 137.0
EH2_k127_7225802_28 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000000000000000009976 114.0
EH2_k127_7225802_29 - - - - 0.0000000000000000000000001112 106.0
EH2_k127_7225802_3 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 4.269e-204 637.0
EH2_k127_7225802_30 metallopeptidase activity - - - 0.000000000000000000000002727 112.0
EH2_k127_7225802_31 PFAM molydopterin dinucleotide-binding region K00201,K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.000000000000000000000004222 106.0
EH2_k127_7225802_32 Predicted membrane protein (DUF2107) K14096 - - 0.00000000000000000000001303 102.0
EH2_k127_7225802_33 - K00960 - 2.7.7.6 0.00000000000000000000007456 97.0
EH2_k127_7225802_34 RNA-binding protein involved in rRNA processing K07569 - - 0.000000000000000000001282 97.0
EH2_k127_7225802_35 Predicted membrane protein (DUF2109) K14094 - - 0.000000000000000000002228 98.0
EH2_k127_7225802_36 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.0000000000000000001592 94.0
EH2_k127_7225802_37 Predicted membrane protein (DUF2108) K14095 - - 0.000000000007168 70.0
EH2_k127_7225802_38 - - - - 0.0000006709 55.0
EH2_k127_7225802_39 Protein of unknown function DUF134 - - - 0.000006736 51.0
EH2_k127_7225802_4 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 584.0
EH2_k127_7225802_40 - K14100 - - 0.000009598 50.0
EH2_k127_7225802_41 - - - - 0.0001065 48.0
EH2_k127_7225802_42 - - - - 0.0001226 49.0
EH2_k127_7225802_5 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 584.0
EH2_k127_7225802_6 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 554.0
EH2_k127_7225802_7 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 395.0
EH2_k127_7225802_8 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 374.0
EH2_k127_7225802_9 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 352.0
EH2_k127_7235711_0 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 610.0
EH2_k127_7235711_1 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 491.0
EH2_k127_7235711_2 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 457.0
EH2_k127_7235711_3 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 429.0
EH2_k127_7235711_4 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 366.0
EH2_k127_7235711_5 transferase hexapeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009103 259.0
EH2_k127_7235711_6 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000003568 246.0
EH2_k127_7235711_7 - - - - 0.000000000000000000000000000000000000000000000000001006 188.0
EH2_k127_7235711_8 PFAM Yip1 domain - - - 0.0000000000000000000000000000000004682 139.0
EH2_k127_7235711_9 - - - - 0.000000000000007401 79.0
EH2_k127_7255048_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1165.0
EH2_k127_7255048_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 536.0
EH2_k127_7255048_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 440.0
EH2_k127_7255048_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 412.0
EH2_k127_7255048_4 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 370.0
EH2_k127_7255048_5 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 331.0
EH2_k127_7255048_6 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000000000000002629 177.0
EH2_k127_7267805_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 464.0
EH2_k127_7267805_1 COG1881 Phospholipid-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000003556 203.0
EH2_k127_7267805_2 Ribonuclease K03469 - 3.1.26.4 0.00000000000000000000000000002989 121.0
EH2_k127_7267805_3 - - - - 0.000000000000000000000000001147 114.0
EH2_k127_7267805_4 beta-lactamase domain protein - - - 0.000000000000000000001735 98.0
EH2_k127_7267805_5 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000001243 62.0
EH2_k127_7297966_0 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 589.0
EH2_k127_7297966_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 416.0
EH2_k127_7297966_2 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009177 325.0
EH2_k127_7297966_3 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002224 258.0
EH2_k127_7297966_4 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000001868 198.0
EH2_k127_7297966_5 - - - - 0.000000000000000000000000000875 115.0
EH2_k127_7297966_6 - - - - 0.000000000000000000000001094 107.0
EH2_k127_7297966_7 dextransucrase activity - - - 0.0000000000000000002958 104.0
EH2_k127_72992_0 KH, type 1, domain K07041 - - 9.656e-305 940.0
EH2_k127_72992_1 Domain of unknown function (DUF814) - - - 1.254e-219 698.0
EH2_k127_72992_10 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000001773 77.0
EH2_k127_72992_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 441.0
EH2_k127_72992_3 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008785 429.0
EH2_k127_72992_4 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 389.0
EH2_k127_72992_5 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008024 374.0
EH2_k127_72992_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 327.0
EH2_k127_72992_7 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000002217 173.0
EH2_k127_72992_8 - - - - 0.0000000000000000000000000000000296 128.0
EH2_k127_72992_9 Papain family cysteine protease K14647 - - 0.0000000000000000000000004339 109.0
EH2_k127_7320053_0 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000007696 186.0
EH2_k127_7320053_1 ABC-type Fe3 transport system permease component K02011 - - 0.000000000000000000000000000000000000000000002709 177.0
EH2_k127_7320053_2 - - - - 0.00000000000000000000000000000000000000003888 165.0
EH2_k127_7368256_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1318.0
EH2_k127_7368256_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 2.163e-243 762.0
EH2_k127_7368256_10 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 384.0
EH2_k127_7368256_11 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 379.0
EH2_k127_7368256_12 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 374.0
EH2_k127_7368256_13 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 357.0
EH2_k127_7368256_14 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 325.0
EH2_k127_7368256_15 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 323.0
EH2_k127_7368256_16 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008061 300.0
EH2_k127_7368256_17 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001838 280.0
EH2_k127_7368256_18 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 272.0
EH2_k127_7368256_19 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004072 265.0
EH2_k127_7368256_2 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.717e-242 758.0
EH2_k127_7368256_20 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008751 255.0
EH2_k127_7368256_21 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007364 232.0
EH2_k127_7368256_22 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000002062 231.0
EH2_k127_7368256_23 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.00000000000000000000000000000000000000000000000000000000000001042 223.0
EH2_k127_7368256_24 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000002455 220.0
EH2_k127_7368256_25 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000001182 216.0
EH2_k127_7368256_26 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000005401 205.0
EH2_k127_7368256_27 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000001212 195.0
EH2_k127_7368256_28 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000000002553 192.0
EH2_k127_7368256_29 Ras family K06945 - - 0.000000000000000000000000000000000000000000001573 169.0
EH2_k127_7368256_3 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 5.301e-237 756.0
EH2_k127_7368256_30 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000004564 165.0
EH2_k127_7368256_31 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000007979 160.0
EH2_k127_7368256_32 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000000000000000001044 129.0
EH2_k127_7368256_33 PFAM Yip1 domain - - - 0.000000000000000000000000000002925 128.0
EH2_k127_7368256_34 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000000000001269 121.0
EH2_k127_7368256_35 Tetratricopeptide repeat - - - 0.0000000000000000000000000009375 123.0
EH2_k127_7368256_36 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000000000000000000004887 113.0
EH2_k127_7368256_37 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000001682 94.0
EH2_k127_7368256_38 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000000000002934 98.0
EH2_k127_7368256_39 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000008997 87.0
EH2_k127_7368256_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 2.661e-235 737.0
EH2_k127_7368256_40 PBS lyase HEAT-like repeat - - - 0.00000000000000001312 88.0
EH2_k127_7368256_41 - - - - 0.0000000000003896 73.0
EH2_k127_7368256_42 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000001966 58.0
EH2_k127_7368256_5 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 1.898e-225 703.0
EH2_k127_7368256_6 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 2.075e-215 674.0
EH2_k127_7368256_7 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 502.0
EH2_k127_7368256_8 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 462.0
EH2_k127_7368256_9 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 413.0
EH2_k127_7374386_0 Uncharacterized protein family, UPF0114 - - - 0.000000000000000000003659 101.0
EH2_k127_7374386_1 - - - - 0.000000000000005659 85.0
EH2_k127_7391203_0 PFAM ABC transporter K00400 - - 3.122e-237 745.0
EH2_k127_7391203_1 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 577.0
EH2_k127_7391203_2 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 0.00000000000000000000000000000000000000000000006521 169.0
EH2_k127_7391203_3 Belongs to the UPF0251 family K06933 - - 0.00000000000000000000000000000000006039 138.0
EH2_k127_7395046_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 495.0
EH2_k127_7395046_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004549 265.0
EH2_k127_7395046_2 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000002499 165.0
EH2_k127_7395046_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000003688 124.0
EH2_k127_7438295_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 524.0
EH2_k127_7438295_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001638 274.0
EH2_k127_7438295_10 - - - - 0.00000000000000003465 89.0
EH2_k127_7438295_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002471 278.0
EH2_k127_7438295_3 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003406 276.0
EH2_k127_7438295_4 PFAM nucleoside recognition domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002288 272.0
EH2_k127_7438295_5 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001303 275.0
EH2_k127_7438295_6 O-methyltransferase K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001125 249.0
EH2_k127_7438295_7 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000000000000000001588 166.0
EH2_k127_7438295_8 Helix-turn-helix XRE-family like proteins K07729 - - 0.0000000000000000000000002606 108.0
EH2_k127_7438295_9 - - - - 0.0000000000000000000000387 104.0
EH2_k127_7524647_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 599.0
EH2_k127_7524647_1 exo-alpha-(2->6)-sialidase activity K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 512.0
EH2_k127_7524647_2 PHP C-terminal domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 422.0
EH2_k127_7524647_3 Translation initiation factor 2 alpha subunit K03237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 367.0
EH2_k127_7524647_4 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 320.0
EH2_k127_7524647_5 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000000003163 184.0
EH2_k127_7524647_6 PFAM Ribosomal protein S27E K02978 - - 0.00000000000000000000005244 99.0
EH2_k127_7524647_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000009559 98.0
EH2_k127_7524647_8 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000000000000004715 78.0
EH2_k127_7524647_9 PFAM TrkA-N domain K03499 - - 0.000000000007452 65.0
EH2_k127_7526_0 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 506.0
EH2_k127_7526_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008467 274.0
EH2_k127_7526_2 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000000000007284 167.0
EH2_k127_7526_3 - - - - 0.0000000000000000000003225 100.0
EH2_k127_7526_4 PspC domain K03973 - - 0.000000000000000004606 86.0
EH2_k127_7550173_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 1.156e-243 769.0
EH2_k127_7550173_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 403.0
EH2_k127_7550173_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000003745 235.0
EH2_k127_7550173_3 - - - - 0.0000000000000000000000000000000000000000000000000006537 196.0
EH2_k127_7550173_4 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000006527 180.0
EH2_k127_7550173_5 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000001383 163.0
EH2_k127_7551254_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 421.0
EH2_k127_7551254_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 299.0
EH2_k127_7551254_2 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000006926 228.0
EH2_k127_7649877_0 Type II secretion system (T2SS), protein F K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 466.0
EH2_k127_7649877_1 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007714 403.0
EH2_k127_7649877_2 PFAM type II secretion system protein E K07332 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004298 263.0
EH2_k127_7649877_3 Belongs to the SUI1 family K03113 - - 0.00000000000000000000000000000000000000000000000000000000000561 207.0
EH2_k127_7690234_0 LOR SDH bifunctional enzyme conserved - - - 1.01e-196 620.0
EH2_k127_7690234_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 527.0
EH2_k127_7690234_2 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 407.0
EH2_k127_7690234_3 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 317.0
EH2_k127_7690234_4 - - - - 0.000000000000000000000000000000000000000000000000000001139 206.0
EH2_k127_7690234_5 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000000000000007499 132.0
EH2_k127_7690234_6 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000003163 86.0
EH2_k127_7690234_7 - - - - 0.0000000000006878 70.0
EH2_k127_7758034_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 8.051e-214 677.0
EH2_k127_7758034_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 458.0
EH2_k127_7758034_2 PFAM GTP-binding protein HSR1-related K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009558 330.0
EH2_k127_7758034_3 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000000000000000000000000000005014 194.0
EH2_k127_7758034_4 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000005109 171.0
EH2_k127_7758034_5 Zn-ribbon containing protein K07163 - - 0.000000000000000000000000001919 115.0
EH2_k127_7894599_0 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 1.012e-197 624.0
EH2_k127_7894599_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.242e-194 611.0
EH2_k127_7894599_2 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 422.0
EH2_k127_7894599_3 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 374.0
EH2_k127_7894599_4 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001772 255.0
EH2_k127_7894599_5 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000001615 151.0
EH2_k127_7894599_6 - - - - 0.000000000000000000000000002139 113.0
EH2_k127_7894599_7 metallopeptidase activity - - - 0.00000000000000000000000002285 114.0
EH2_k127_7975317_0 Heat shock 70 kDa protein K04043 - - 2.066e-313 968.0
EH2_k127_7975317_1 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 565.0
EH2_k127_7975317_10 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 337.0
EH2_k127_7975317_11 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002392 280.0
EH2_k127_7975317_12 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000000000000001434 214.0
EH2_k127_7975317_13 COG1881 Phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000004862 202.0
EH2_k127_7975317_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000008336 172.0
EH2_k127_7975317_15 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.0000000000000000000000000000000001935 142.0
EH2_k127_7975317_16 Ribonuclease K03469 - 3.1.26.4 0.00000000000000000000000000000001463 133.0
EH2_k127_7975317_17 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000002912 115.0
EH2_k127_7975317_18 - - - - 0.0000000000000000000000000004236 115.0
EH2_k127_7975317_2 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 550.0
EH2_k127_7975317_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 530.0
EH2_k127_7975317_4 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 521.0
EH2_k127_7975317_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 456.0
EH2_k127_7975317_6 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 410.0
EH2_k127_7975317_7 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 378.0
EH2_k127_7975317_8 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 366.0
EH2_k127_7975317_9 RNA methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 359.0
EH2_k127_81149_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 1.228e-299 929.0
EH2_k127_81149_1 Belongs to the TPP enzyme family K00158 - 1.2.3.3 2.081e-246 773.0
EH2_k127_81149_10 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001105 279.0
EH2_k127_81149_11 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003735 263.0
EH2_k127_81149_12 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000003402 244.0
EH2_k127_81149_13 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000001812 177.0
EH2_k127_81149_14 PFAM TspO MBR family K05770 - - 0.0000000000000000000000000000000000000000000005616 173.0
EH2_k127_81149_15 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000000000000003695 161.0
EH2_k127_81149_16 Protein of unknown function (DUF1622) - - - 0.00000000000000000000000000001721 121.0
EH2_k127_81149_17 - - - - 0.000000000000000003481 92.0
EH2_k127_81149_18 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.0000000000001806 74.0
EH2_k127_81149_2 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 552.0
EH2_k127_81149_3 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 524.0
EH2_k127_81149_4 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007388 446.0
EH2_k127_81149_5 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 434.0
EH2_k127_81149_6 Branched-chain amino acid transport system permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 375.0
EH2_k127_81149_7 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 364.0
EH2_k127_81149_8 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 347.0
EH2_k127_81149_9 PHP-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 295.0
EH2_k127_8221038_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 8.692e-285 882.0
EH2_k127_8221038_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 1.019e-221 694.0
EH2_k127_8221038_10 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000000000001265 130.0
EH2_k127_8221038_12 TIR domain - - - 0.0000000000000002231 85.0
EH2_k127_8221038_13 - - - - 0.00000000005126 66.0
EH2_k127_8221038_2 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 605.0
EH2_k127_8221038_3 COG0438 Glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 420.0
EH2_k127_8221038_4 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 338.0
EH2_k127_8221038_5 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000201 267.0
EH2_k127_8221038_6 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000004346 228.0
EH2_k127_8221038_7 DNA polymerase LigD, polymerase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000007343 215.0
EH2_k127_8221038_8 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000001107 196.0
EH2_k127_8221038_9 DNA ligase D DNA polymerase LigD K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000007723 176.0
EH2_k127_8722_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 3.817e-286 895.0
EH2_k127_8722_1 SMART Elongator protein 3 MiaB NifB - - - 1.092e-254 798.0
EH2_k127_8722_10 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 330.0
EH2_k127_8722_11 sensor histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 331.0
EH2_k127_8722_12 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 288.0
EH2_k127_8722_13 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 290.0
EH2_k127_8722_14 KH domain protein K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002439 271.0
EH2_k127_8722_15 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003614 243.0
EH2_k127_8722_16 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000000308 228.0
EH2_k127_8722_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000004076 223.0
EH2_k127_8722_18 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000001922 209.0
EH2_k127_8722_19 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000128 209.0
EH2_k127_8722_2 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 579.0
EH2_k127_8722_20 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000001168 192.0
EH2_k127_8722_21 PFAM response regulator receiveR - - - 0.0000000000000000000000000000000000000000000000001022 183.0
EH2_k127_8722_22 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000004899 163.0
EH2_k127_8722_23 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000000000000000000000001233 154.0
EH2_k127_8722_24 - - - - 0.000000001091 66.0
EH2_k127_8722_25 penicillin binding K05367 - 2.4.1.129 0.00000005923 55.0
EH2_k127_8722_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009443 518.0
EH2_k127_8722_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 505.0
EH2_k127_8722_5 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 481.0
EH2_k127_8722_6 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 469.0
EH2_k127_8722_7 PFAM elongation factor Tu domain 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 412.0
EH2_k127_8722_8 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 355.0
EH2_k127_8722_9 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009447 337.0
EH2_k127_87425_0 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 346.0
EH2_k127_87425_1 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001412 262.0
EH2_k127_87425_2 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000005967 185.0
EH2_k127_87425_3 Uncharacterized protein family, UPF0114 - - - 0.00000000000000000000000000000000000006266 149.0
EH2_k127_99424_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 2.702e-264 817.0
EH2_k127_99424_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 9.934e-212 666.0
EH2_k127_99424_10 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 469.0
EH2_k127_99424_11 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 459.0
EH2_k127_99424_12 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 407.0
EH2_k127_99424_13 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 395.0
EH2_k127_99424_14 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 367.0
EH2_k127_99424_15 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 338.0
EH2_k127_99424_16 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 336.0
EH2_k127_99424_17 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 314.0
EH2_k127_99424_18 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 309.0
EH2_k127_99424_19 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 284.0
EH2_k127_99424_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 6.424e-206 647.0
EH2_k127_99424_20 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001524 281.0
EH2_k127_99424_21 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006038 268.0
EH2_k127_99424_22 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000008697 251.0
EH2_k127_99424_23 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000000000107 240.0
EH2_k127_99424_24 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000009296 238.0
EH2_k127_99424_25 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000861 232.0
EH2_k127_99424_26 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000028 229.0
EH2_k127_99424_27 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000009007 188.0
EH2_k127_99424_28 Yip1 domain - - - 0.00000000000000000000000000000000000000000000004588 177.0
EH2_k127_99424_29 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000007591 163.0
EH2_k127_99424_3 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 4.399e-198 631.0
EH2_k127_99424_30 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000000002038 148.0
EH2_k127_99424_31 Domain of unknown function (DUF1805) - - - 0.00000000000000000000000000151 114.0
EH2_k127_99424_32 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000000000000001555 116.0
EH2_k127_99424_33 PFAM condensation domain protein - - - 0.0000000000000000000000001555 121.0
EH2_k127_99424_34 Protein of unknown function (DUF2953) - - - 0.0000000000000000007097 96.0
EH2_k127_99424_35 - - - - 0.00000000000000003459 85.0
EH2_k127_99424_36 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00005689 52.0
EH2_k127_99424_4 Anion transporter K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 576.0
EH2_k127_99424_5 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 569.0
EH2_k127_99424_6 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 544.0
EH2_k127_99424_7 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 537.0
EH2_k127_99424_8 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 479.0
EH2_k127_99424_9 Radical SAM ThiC family K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 476.0