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Overview

ID MAG01064
Name EH2_bin.58
Sample SMP0029
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JAJRCM01
Species
Assembly information
Completeness (%) 76.19
Contamination (%) 0.5
GC content (%) 52.0
N50 (bp) 16,765
Genome size (bp) 1,132,794

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1272

Gene name Description KEGG GOs EC E-value Score Sequence
EH2_k127_1032098_0 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 5.193e-213 672.0
EH2_k127_1032098_1 Protein of unknown function (DUF4013) - - - 0.000000000000000000666 87.0
EH2_k127_1097629_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 1.792e-296 927.0
EH2_k127_1097629_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.067e-289 906.0
EH2_k127_1097629_10 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 546.0
EH2_k127_1097629_11 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009384 526.0
EH2_k127_1097629_12 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 502.0
EH2_k127_1097629_13 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 496.0
EH2_k127_1097629_14 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 481.0
EH2_k127_1097629_15 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 452.0
EH2_k127_1097629_16 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 415.0
EH2_k127_1097629_17 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 421.0
EH2_k127_1097629_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 387.0
EH2_k127_1097629_19 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 368.0
EH2_k127_1097629_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 9.846e-276 866.0
EH2_k127_1097629_20 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 338.0
EH2_k127_1097629_21 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 321.0
EH2_k127_1097629_22 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 307.0
EH2_k127_1097629_23 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001194 273.0
EH2_k127_1097629_24 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001168 261.0
EH2_k127_1097629_25 KH domain protein K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001573 255.0
EH2_k127_1097629_26 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000002866 243.0
EH2_k127_1097629_27 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000007272 229.0
EH2_k127_1097629_28 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000000000000006263 227.0
EH2_k127_1097629_29 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000000000000000000000000234 220.0
EH2_k127_1097629_3 SMART Elongator protein 3 MiaB NifB - - - 4.687e-259 811.0
EH2_k127_1097629_30 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000005935 208.0
EH2_k127_1097629_31 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000001468 196.0
EH2_k127_1097629_32 COG0518 GMP synthase - Glutamine amidotransferase domain K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000002425 198.0
EH2_k127_1097629_33 Peptidase family M23 - - - 0.0000000000000000000000000000000000000002095 156.0
EH2_k127_1097629_34 Flavodoxin - - - 0.00000000000000000000000000000000000000664 150.0
EH2_k127_1097629_35 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000001072 142.0
EH2_k127_1097629_36 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000001826 136.0
EH2_k127_1097629_37 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000000000000000000000003515 115.0
EH2_k127_1097629_38 protein conserved in archaea - - - 0.0000000000000000000000000004458 116.0
EH2_k127_1097629_39 nucleic acid binding OB-fold tRNA helicase-type - - - 0.00000000000000000000000000155 115.0
EH2_k127_1097629_4 Involved in regulation of DNA replication K10725 - - 9.056e-209 655.0
EH2_k127_1097629_40 - - - - 0.00000000000000000000002222 111.0
EH2_k127_1097629_41 - - - - 0.000000000000000000003177 100.0
EH2_k127_1097629_42 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000001284 95.0
EH2_k127_1097629_43 transcriptional regulators K03724 - - 0.00000000000000000006381 91.0
EH2_k127_1097629_44 Belongs to the UPF0434 family - - - 0.0000000000000000002154 88.0
EH2_k127_1097629_45 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000001069 86.0
EH2_k127_1097629_46 COG0457 FOG TPR repeat - - - 0.000005458 52.0
EH2_k127_1097629_47 - - - - 0.0003797 46.0
EH2_k127_1097629_5 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 2.293e-202 640.0
EH2_k127_1097629_6 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 589.0
EH2_k127_1097629_7 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 584.0
EH2_k127_1097629_8 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 587.0
EH2_k127_1097629_9 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 556.0
EH2_k127_127164_0 Conserved region in glutamate synthase - - - 7.593e-290 895.0
EH2_k127_127164_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002312 278.0
EH2_k127_127164_2 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002829 277.0
EH2_k127_127164_3 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004081 285.0
EH2_k127_127164_4 Sodium Bile acid symporter family K03325 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.0000000000000000000000000000000000000000000000000000000005725 203.0
EH2_k127_127164_5 Putative zinc ribbon domain - - - 0.000000000000000002427 89.0
EH2_k127_127164_6 TIR domain - - - 0.000000000000578 75.0
EH2_k127_127164_7 - - - - 0.00000003111 57.0
EH2_k127_1390990_0 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 417.0
EH2_k127_1390990_1 HAD-hyrolase-like K07025 - - 0.0000000000000000000000000000000000001581 146.0
EH2_k127_1390990_2 Lon protease (S16) C-terminal proteolytic domain - - - 0.0000000001759 63.0
EH2_k127_1537386_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 2.414e-241 751.0
EH2_k127_1537386_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008689 520.0
EH2_k127_1537386_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 513.0
EH2_k127_1537386_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 433.0
EH2_k127_1537386_4 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 416.0
EH2_k127_1537386_5 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001283 247.0
EH2_k127_1537386_6 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000005455 214.0
EH2_k127_1537386_7 NADPH-dependent FMN reductase - - - 0.00000000000000000000000001032 110.0
EH2_k127_1537386_8 chorismate mutase K04093 - 5.4.99.5 0.0000000000000000000000002458 109.0
EH2_k127_1537386_9 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000000000000293 103.0
EH2_k127_192451_0 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 437.0
EH2_k127_192451_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 403.0
EH2_k127_192451_10 Class III signal peptide - - - 0.0000002704 56.0
EH2_k127_192451_2 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 338.0
EH2_k127_192451_3 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001922 279.0
EH2_k127_192451_4 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000001135 169.0
EH2_k127_192451_6 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000006108 106.0
EH2_k127_192451_7 PFAM helix-turn-helix domain protein K07729 - - 0.000000000000000000008567 94.0
EH2_k127_192451_8 PFAM helix-turn-helix domain protein K07729 - - 0.000000000000000001257 87.0
EH2_k127_192451_9 membrane protein (DUF2178) - - - 0.00000000007262 69.0
EH2_k127_1951077_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 618.0
EH2_k127_1951077_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 404.0
EH2_k127_1951077_2 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000000000000004668 149.0
EH2_k127_1951077_3 - - - - 0.00000000005285 63.0
EH2_k127_1971113_0 pyrroline-5-carboxylate reductase activity K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000004444 256.0
EH2_k127_1971113_1 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000002512 242.0
EH2_k127_1971113_2 - - - - 0.0000000000000000000000000000000000000001123 155.0
EH2_k127_1971113_3 DGC domain - - - 0.000000000000000000000277 101.0
EH2_k127_2069156_0 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 565.0
EH2_k127_2069156_1 Mitochondrial small ribosomal subunit Rsm22 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 426.0
EH2_k127_2069156_2 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 338.0
EH2_k127_2069156_3 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 307.0
EH2_k127_2069156_4 ATPases associated with a variety of cellular activities K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 307.0
EH2_k127_2069156_5 Protein phosphatase 2C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000587 246.0
EH2_k127_2069156_6 ABC-type metal ion transport system periplasmic component surface adhesin K09815 - - 0.000000000000000000000000000000000000000000000000000000000000003575 227.0
EH2_k127_2069156_7 Right handed beta helix region K10297 - - 0.0000000000000000000000000000000000205 152.0
EH2_k127_2069156_8 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000002295 79.0
EH2_k127_2069156_9 iron dependent repressor K03709 - - 0.00000005565 55.0
EH2_k127_2098073_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 516.0
EH2_k127_2098073_1 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 484.0
EH2_k127_2098073_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 384.0
EH2_k127_2098073_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 312.0
EH2_k127_2098073_4 methanogen marker protein 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001912 286.0
EH2_k127_2098073_5 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000001488 249.0
EH2_k127_2098073_6 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000001402 163.0
EH2_k127_2098073_7 Belongs to the UPF0146 family K09713 - - 0.00000000000000000000000000000000000000001028 160.0
EH2_k127_2098073_8 PFAM peptidase zinc-dependent K06974 - - 0.00000000000000000000000000000000000000002175 156.0
EH2_k127_2098073_9 transcription factor (CBF NF-Y) - - - 0.00000000000000000000000000697 113.0
EH2_k127_214821_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 8.526e-236 753.0
EH2_k127_214821_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009998 251.0
EH2_k127_214821_2 Protein of unknown function (DUF1648) - - - 0.00000000000000000000000000000000000000000000000000000000002526 214.0
EH2_k127_214821_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000001522 79.0
EH2_k127_2264676_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 2.618e-269 833.0
EH2_k127_2264676_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 4.579e-246 770.0
EH2_k127_2264676_2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 5.656e-217 677.0
EH2_k127_2264676_4 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001138 248.0
EH2_k127_2285211_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.465e-248 777.0
EH2_k127_2285211_1 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 3.266e-244 760.0
EH2_k127_2285211_10 Major Facilitator Superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 448.0
EH2_k127_2285211_11 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 431.0
EH2_k127_2285211_12 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 406.0
EH2_k127_2285211_13 PFAM Radical SAM domain protein K07129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 402.0
EH2_k127_2285211_14 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 398.0
EH2_k127_2285211_15 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 391.0
EH2_k127_2285211_16 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 385.0
EH2_k127_2285211_17 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 370.0
EH2_k127_2285211_18 PFAM GTP-binding protein HSR1-related K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 365.0
EH2_k127_2285211_19 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 352.0
EH2_k127_2285211_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.441e-241 758.0
EH2_k127_2285211_20 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 338.0
EH2_k127_2285211_21 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 336.0
EH2_k127_2285211_22 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 317.0
EH2_k127_2285211_23 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 309.0
EH2_k127_2285211_24 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004827 304.0
EH2_k127_2285211_25 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 324.0
EH2_k127_2285211_26 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 291.0
EH2_k127_2285211_27 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002513 281.0
EH2_k127_2285211_28 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007527 267.0
EH2_k127_2285211_29 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005298 261.0
EH2_k127_2285211_3 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 3.666e-218 687.0
EH2_k127_2285211_30 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000003059 252.0
EH2_k127_2285211_31 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001354 252.0
EH2_k127_2285211_32 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000001406 234.0
EH2_k127_2285211_33 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000115 228.0
EH2_k127_2285211_34 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000008761 217.0
EH2_k127_2285211_35 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000003773 211.0
EH2_k127_2285211_36 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000004732 208.0
EH2_k127_2285211_37 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000000000000000000000000000006409 203.0
EH2_k127_2285211_38 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000005985 200.0
EH2_k127_2285211_39 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000005535 190.0
EH2_k127_2285211_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 2.555e-213 668.0
EH2_k127_2285211_40 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000007236 187.0
EH2_k127_2285211_41 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000003005 188.0
EH2_k127_2285211_42 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000001178 185.0
EH2_k127_2285211_43 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.0000000000000000000000000000000000000000000000000183 181.0
EH2_k127_2285211_44 Zn-ribbon containing protein K07163 - - 0.0000000000000000000000000000000000000000000000006526 177.0
EH2_k127_2285211_45 AMP binding - - - 0.000000000000000000000000000000000000000000001146 176.0
EH2_k127_2285211_46 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000000000000000004262 166.0
EH2_k127_2285211_47 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000001026 170.0
EH2_k127_2285211_48 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000000000000000000004061 138.0
EH2_k127_2285211_49 - - - - 0.000000000000000000000000000000001925 133.0
EH2_k127_2285211_5 Ferrous iron transport B domain protein K04759 - - 3.546e-204 653.0
EH2_k127_2285211_50 iron dependent repressor K03709,K04758 - - 0.000000000000000000000000000000008808 135.0
EH2_k127_2285211_51 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.00000000000000000000000000000002023 126.0
EH2_k127_2285211_52 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000003713 122.0
EH2_k127_2285211_53 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000001575 117.0
EH2_k127_2285211_54 ThiS family K03636 - - 0.0000000000000000000000000002161 117.0
EH2_k127_2285211_55 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0009847,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015297,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032502,GO:0034220,GO:0035725,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000007827 124.0
EH2_k127_2285211_56 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000002128 103.0
EH2_k127_2285211_57 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000002218 91.0
EH2_k127_2285211_58 Ferredoxin K05337 - - 0.0000000000000000009461 89.0
EH2_k127_2285211_59 PFAM ABC-2 type transporter K01992 - - 0.0000000000000001209 84.0
EH2_k127_2285211_6 Helix-hairpin-helix domain K02347 - - 3.27e-200 639.0
EH2_k127_2285211_60 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000003634 82.0
EH2_k127_2285211_61 - - - - 0.000000000000003758 82.0
EH2_k127_2285211_62 PFAM ABC-2 type transporter K01992 - - 0.00000000000728 66.0
EH2_k127_2285211_63 PspC domain K03973 - - 0.0000000789 55.0
EH2_k127_2285211_64 - - - - 0.000009877 54.0
EH2_k127_2285211_65 ATP hydrolysis coupled proton transport K02123 - - 0.0002758 45.0
EH2_k127_2285211_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 560.0
EH2_k127_2285211_8 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 482.0
EH2_k127_2285211_9 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005254 454.0
EH2_k127_2339183_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1313.0
EH2_k127_2339183_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.123e-305 949.0
EH2_k127_2339183_10 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 347.0
EH2_k127_2339183_11 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 341.0
EH2_k127_2339183_12 Type II secretion system (T2SS), protein F K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 338.0
EH2_k127_2339183_13 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 341.0
EH2_k127_2339183_14 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009507 327.0
EH2_k127_2339183_15 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000889 284.0
EH2_k127_2339183_16 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001865 286.0
EH2_k127_2339183_17 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000251 211.0
EH2_k127_2339183_18 PFAM TrkA-C domain K07228 - - 0.000000000000000000000000000000000000000000000000000000000006819 211.0
EH2_k127_2339183_19 - - - - 0.00000000000000000000000000000000000000000000000000000001682 199.0
EH2_k127_2339183_2 PFAM type II secretion system protein E K07332 - - 1.683e-281 886.0
EH2_k127_2339183_20 - - - - 0.0000000000000000000000000000000000000000000000000000000443 211.0
EH2_k127_2339183_21 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000005715 189.0
EH2_k127_2339183_22 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000003412 177.0
EH2_k127_2339183_23 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000000000000006665 183.0
EH2_k127_2339183_24 - - - - 0.000000000000000000000000000000000000000000000002286 183.0
EH2_k127_2339183_25 Roadblock LC7 K07131 - - 0.000000000000000000000000000000000000000000004417 165.0
EH2_k127_2339183_26 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000001425 164.0
EH2_k127_2339183_27 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000001098 164.0
EH2_k127_2339183_28 - - - - 0.000000000000000000000000000000000000000006191 161.0
EH2_k127_2339183_29 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000000000000000000004891 138.0
EH2_k127_2339183_3 PFAM PilT protein domain protein K06865 - - 1.908e-281 876.0
EH2_k127_2339183_30 - - - - 0.000000000000000000000000003406 113.0
EH2_k127_2339183_31 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000002823 110.0
EH2_k127_2339183_32 PFAM response regulator receiver K11443 - - 0.00000000000000000000000007932 111.0
EH2_k127_2339183_33 Type II secretion system (T2SS), protein F K07333 - - 0.00000000000000000000004873 106.0
EH2_k127_2339183_34 PFAM peptidase U32 K08303 - - 0.0000000000000000000036 96.0
EH2_k127_2339183_35 E-Z type HEAT repeats - - - 0.000000000005925 70.0
EH2_k127_2339183_36 - - - - 0.00000003724 63.0
EH2_k127_2339183_4 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 459.0
EH2_k127_2339183_5 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 429.0
EH2_k127_2339183_6 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 395.0
EH2_k127_2339183_7 TIGRFAM cell division ATPase MinD K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 385.0
EH2_k127_2339183_8 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 371.0
EH2_k127_2339183_9 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 347.0
EH2_k127_236850_0 DEAD DEAH box helicase domain protein K03725 - - 1.623e-282 882.0
EH2_k127_236850_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 8.361e-236 738.0
EH2_k127_236850_10 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000000000008322 233.0
EH2_k127_236850_11 UbiA prenyltransferase family - - - 0.0000000000000000000000000003233 116.0
EH2_k127_236850_12 - - - - 0.0000000000000006435 80.0
EH2_k127_236850_2 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 1.544e-228 716.0
EH2_k127_236850_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 550.0
EH2_k127_236850_4 SMART regulatory protein, Crp K07730 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 385.0
EH2_k127_236850_5 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 389.0
EH2_k127_236850_6 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 294.0
EH2_k127_236850_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008073 281.0
EH2_k127_236850_8 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001517 258.0
EH2_k127_236850_9 ArsR transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005724 243.0
EH2_k127_2413672_0 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 514.0
EH2_k127_2413672_1 sensor histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 337.0
EH2_k127_2413672_2 aminotransferase class I and II K00812 - 2.6.1.1 0.0000002124 53.0
EH2_k127_2508267_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 3.597e-253 791.0
EH2_k127_2508267_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 376.0
EH2_k127_2508267_2 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 328.0
EH2_k127_2508267_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000001194 117.0
EH2_k127_2530968_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.19e-316 975.0
EH2_k127_2530968_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 4.529e-292 904.0
EH2_k127_2530968_10 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 319.0
EH2_k127_2530968_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 310.0
EH2_k127_2530968_12 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 302.0
EH2_k127_2530968_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 284.0
EH2_k127_2530968_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003677 248.0
EH2_k127_2530968_15 - - - - 0.000000000000000000000000000000000000000000001264 169.0
EH2_k127_2530968_16 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000007449 120.0
EH2_k127_2530968_17 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000000000003259 111.0
EH2_k127_2530968_18 - - - - 0.000000000000000000001979 93.0
EH2_k127_2530968_19 ATP synthase subunit C K02124 - - 0.00000000000000000005475 92.0
EH2_k127_2530968_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 4.413e-268 829.0
EH2_k127_2530968_20 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.0000000000000000006593 89.0
EH2_k127_2530968_21 PHP domain protein - - - 0.00000000000002438 74.0
EH2_k127_2530968_23 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000005289 72.0
EH2_k127_2530968_24 Trypsin - - - 0.00000000002243 66.0
EH2_k127_2530968_25 PHP domain protein - - - 0.000000004566 59.0
EH2_k127_2530968_26 PBS lyase HEAT-like repeat - - - 0.00006357 53.0
EH2_k127_2530968_27 H subunit K02107 - - 0.0006253 47.0
EH2_k127_2530968_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 7.899e-252 782.0
EH2_k127_2530968_4 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.804e-229 728.0
EH2_k127_2530968_5 V-type ATPase 116kDa subunit family K02123 - - 7.756e-207 661.0
EH2_k127_2530968_6 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 564.0
EH2_k127_2530968_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 486.0
EH2_k127_2530968_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 362.0
EH2_k127_2530968_9 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 349.0
EH2_k127_2563057_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000601 400.0
EH2_k127_2563057_1 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000000000000000000000003158 231.0
EH2_k127_2563057_2 UPF0056 membrane protein K05595 - - 0.000000000000000000000000000000000000000000003599 167.0
EH2_k127_2563057_3 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000000000000000000000000001352 130.0
EH2_k127_2563057_4 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.00000000122 63.0
EH2_k127_2563083_0 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 477.0
EH2_k127_2563083_1 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000002123 215.0
EH2_k127_257575_0 Protein of unknown function (DUF460) K09150 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007269 587.0
EH2_k127_257575_1 Domain of unknown function DUF87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 503.0
EH2_k127_257575_10 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 288.0
EH2_k127_257575_11 FHA domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000017 273.0
EH2_k127_257575_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004307 256.0
EH2_k127_257575_13 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000000003777 216.0
EH2_k127_257575_14 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000001124 191.0
EH2_k127_257575_15 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000004788 156.0
EH2_k127_257575_16 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000005573 146.0
EH2_k127_257575_17 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.00000000000006029 77.0
EH2_k127_257575_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 449.0
EH2_k127_257575_3 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 404.0
EH2_k127_257575_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009884 390.0
EH2_k127_257575_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 375.0
EH2_k127_257575_6 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 358.0
EH2_k127_257575_7 Rio2, N-terminal K07179 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 338.0
EH2_k127_257575_8 Domain of unknown function DUF128 K21640 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 324.0
EH2_k127_257575_9 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 320.0
EH2_k127_271291_0 AMP-binding enzyme - - - 4.154e-222 695.0
EH2_k127_271291_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000001065 183.0
EH2_k127_271291_2 Belongs to the UPF0216 family K09737 - - 0.00000000000000000000000000000000000000000007729 163.0
EH2_k127_271291_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000008273 158.0
EH2_k127_271291_4 PFAM phosphatidate cytidylyltransferase - - - 0.000000000000000000000000000000000000003656 154.0
EH2_k127_271291_5 - - - - 0.00000000000000000000000000000000001532 135.0
EH2_k127_271291_6 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000006328 127.0
EH2_k127_271291_7 - K00960 - 2.7.7.6 0.0000000000000000000001186 97.0
EH2_k127_271291_8 PFAM Radical SAM domain protein - - - 0.00007463 45.0
EH2_k127_271291_9 PFAM Radical SAM domain protein - - - 0.0001344 46.0
EH2_k127_2760080_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 592.0
EH2_k127_2760080_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 409.0
EH2_k127_2760080_2 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 295.0
EH2_k127_2760080_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 293.0
EH2_k127_2760080_4 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000004345 211.0
EH2_k127_2760080_5 TfoX N-terminal domain - - - 0.0000000000000001041 86.0
EH2_k127_2760080_6 metallopeptidase activity - - - 0.0000000000000001077 86.0
EH2_k127_3092936_0 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 422.0
EH2_k127_3092936_1 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 317.0
EH2_k127_3092936_2 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001477 249.0
EH2_k127_3092936_3 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.000000000000000000000000000000000000000000000000000000000000000000003193 241.0
EH2_k127_3092936_4 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000005857 236.0
EH2_k127_3092936_5 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000000002962 146.0
EH2_k127_3121635_0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 350.0
EH2_k127_3121635_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000009777 154.0
EH2_k127_3121635_2 DNA-binding transcription factor activity K03892 - - 0.000000000000000001765 88.0
EH2_k127_3121635_4 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette K15342 - - 0.00004313 48.0
EH2_k127_3127376_0 E1-E2 ATPase K17686 - 3.6.3.54 0.0 1038.0
EH2_k127_3127376_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.478e-250 781.0
EH2_k127_3127376_10 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 546.0
EH2_k127_3127376_11 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 539.0
EH2_k127_3127376_12 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 525.0
EH2_k127_3127376_13 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 488.0
EH2_k127_3127376_14 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 483.0
EH2_k127_3127376_15 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 472.0
EH2_k127_3127376_16 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 466.0
EH2_k127_3127376_17 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 447.0
EH2_k127_3127376_18 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 418.0
EH2_k127_3127376_19 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 413.0
EH2_k127_3127376_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 4.364e-223 703.0
EH2_k127_3127376_20 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 410.0
EH2_k127_3127376_21 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 401.0
EH2_k127_3127376_22 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 393.0
EH2_k127_3127376_23 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 379.0
EH2_k127_3127376_24 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 362.0
EH2_k127_3127376_25 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 355.0
EH2_k127_3127376_26 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 336.0
EH2_k127_3127376_27 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 327.0
EH2_k127_3127376_28 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 312.0
EH2_k127_3127376_29 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 311.0
EH2_k127_3127376_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 4.371e-213 668.0
EH2_k127_3127376_30 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002064 284.0
EH2_k127_3127376_31 ABC-type tungstate transport system, periplasmic component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005316 281.0
EH2_k127_3127376_32 Protein of unknown function (DUF655) K07572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001309 274.0
EH2_k127_3127376_33 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001325 273.0
EH2_k127_3127376_34 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003257 270.0
EH2_k127_3127376_35 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001029 267.0
EH2_k127_3127376_36 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000000000000000000000000000000000000000000000009749 261.0
EH2_k127_3127376_37 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000493 242.0
EH2_k127_3127376_38 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000007971 225.0
EH2_k127_3127376_39 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000002152 228.0
EH2_k127_3127376_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 9.404e-208 651.0
EH2_k127_3127376_40 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000544 211.0
EH2_k127_3127376_41 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000003334 211.0
EH2_k127_3127376_42 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000008375 196.0
EH2_k127_3127376_43 Domain of unknown function (DUF1890) - - - 0.000000000000000000000000000000000000000000000000003197 185.0
EH2_k127_3127376_44 archaeal Zn-finger protein - - - 0.00000000000000000000000000000000000000000000000001305 185.0
EH2_k127_3127376_45 Desulfoferrodoxin ferrous iron-binding K05919 - 1.15.1.2 0.0000000000000000000000000000000000000000000000005384 177.0
EH2_k127_3127376_46 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000000000000000000000001513 171.0
EH2_k127_3127376_47 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000001951 166.0
EH2_k127_3127376_48 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000000000004249 162.0
EH2_k127_3127376_49 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000638 155.0
EH2_k127_3127376_5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 594.0
EH2_k127_3127376_50 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000000000000006646 147.0
EH2_k127_3127376_51 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000007642 145.0
EH2_k127_3127376_52 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000000000000002469 134.0
EH2_k127_3127376_53 PFAM PRC-barrel domain - - - 0.0000000000000000000000000000000003921 132.0
EH2_k127_3127376_54 - - - - 0.000000000000000000000000000000001421 133.0
EH2_k127_3127376_55 Domain of unknown function (DUF1894) - - - 0.0000000000000000000000000000004643 124.0
EH2_k127_3127376_56 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000005367 107.0
EH2_k127_3127376_57 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000002182 105.0
EH2_k127_3127376_58 PBS lyase HEAT-like repeat - - - 0.00000000000000000000004221 111.0
EH2_k127_3127376_59 Transcriptional regulator K07108 - - 0.0000000000000000000001128 101.0
EH2_k127_3127376_6 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 583.0
EH2_k127_3127376_60 rubredoxin - - - 0.0000000000000000000002626 98.0
EH2_k127_3127376_61 CRS1_YhbY K07574 - - 0.0000000000000000000005069 97.0
EH2_k127_3127376_62 - - - - 0.000000000000000000001866 100.0
EH2_k127_3127376_63 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000001635 91.0
EH2_k127_3127376_64 structural constituent of ribosome K02924 - - 0.0000000000000000002417 89.0
EH2_k127_3127376_65 PFAM Ribosomal LX protein K02944 - - 0.000000000008388 69.0
EH2_k127_3127376_66 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00001304 49.0
EH2_k127_3127376_67 COG3364 Zn-ribbon containing protein K07163 - - 0.0003928 52.0
EH2_k127_3127376_7 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 578.0
EH2_k127_3127376_8 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 564.0
EH2_k127_3127376_9 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 561.0
EH2_k127_3136172_0 in RNase L inhibitor, RLI K06174 - - 3.298e-278 868.0
EH2_k127_3136172_1 Domain of unknown function (DUF814) - - - 2.188e-204 654.0
EH2_k127_3136172_10 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000000005398 200.0
EH2_k127_3136172_11 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000008649 186.0
EH2_k127_3136172_12 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.000000000000000000000000000000000004008 143.0
EH2_k127_3136172_13 RNase L inhibitor, RLI - - - 0.0000000000000000000000003884 108.0
EH2_k127_3136172_14 AAA-like domain K06915 - - 0.00000000000000000003145 91.0
EH2_k127_3136172_15 PFAM YHS domain - - - 0.00000000000009133 72.0
EH2_k127_3136172_16 - - - - 0.0000228 50.0
EH2_k127_3136172_2 PFAM formate nitrite transporter K21993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 426.0
EH2_k127_3136172_3 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 400.0
EH2_k127_3136172_4 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 344.0
EH2_k127_3136172_5 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008366 329.0
EH2_k127_3136172_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 320.0
EH2_k127_3136172_7 PFAM metallophosphoesterase K07096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 295.0
EH2_k127_3136172_8 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000008407 247.0
EH2_k127_3136172_9 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.0000000000000000000000000000000000000000000000000000000000000008704 222.0
EH2_k127_3234756_0 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 612.0
EH2_k127_3234756_1 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001271 273.0
EH2_k127_3234756_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000001859 183.0
EH2_k127_3295466_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 574.0
EH2_k127_3295466_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 563.0
EH2_k127_3295466_2 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000006571 117.0
EH2_k127_3315621_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.575e-288 902.0
EH2_k127_3315621_1 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 411.0
EH2_k127_3315621_2 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000004259 231.0
EH2_k127_3333992_0 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 362.0
EH2_k127_3333992_1 pyrroline-5-carboxylate reductase activity K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000478 266.0
EH2_k127_3333992_2 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000009312 236.0
EH2_k127_3333992_3 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000002457 197.0
EH2_k127_3333992_4 - - - - 0.000000000000000000000000000000000000008512 149.0
EH2_k127_3333992_5 DGC domain - - - 0.00000000000000000003935 95.0
EH2_k127_3333992_6 Predicted permease K07089 - - 0.0000000000000000002872 87.0
EH2_k127_337478_0 PFAM glutamate--cysteine ligase, GCS2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006998 436.0
EH2_k127_337478_1 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 404.0
EH2_k127_337478_2 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000003714 148.0
EH2_k127_337478_3 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000002402 99.0
EH2_k127_337478_4 Thioredoxin - - - 0.0000000002082 62.0
EH2_k127_3381197_0 Involved in cell shape control K22222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 334.0
EH2_k127_3381197_1 - - - - 0.0000000000000000000000000000000000000000000002229 181.0
EH2_k127_3381197_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000001032 96.0
EH2_k127_3402498_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 2.703e-199 623.0
EH2_k127_3402498_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 331.0
EH2_k127_3402498_2 RNA-binding protein involved in rRNA processing K07569 - - 0.0000000000000000001358 92.0
EH2_k127_376943_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1201.0
EH2_k127_376943_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 3.77e-299 937.0
EH2_k127_376943_10 - - - - 0.0000008887 57.0
EH2_k127_376943_11 Helix-turn-helix domain - - - 0.00005458 49.0
EH2_k127_376943_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.32e-294 913.0
EH2_k127_376943_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 339.0
EH2_k127_376943_4 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 336.0
EH2_k127_376943_5 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 313.0
EH2_k127_376943_6 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 292.0
EH2_k127_376943_7 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000001758 218.0
EH2_k127_376943_8 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000002767 188.0
EH2_k127_376943_9 - K00960 - 2.7.7.6 0.000000000000000000000004717 101.0
EH2_k127_38898_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 462.0
EH2_k127_38898_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 308.0
EH2_k127_38898_2 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000002203 214.0
EH2_k127_390799_0 acid binding OB-fold tRNA helicase-type K07463 - - 3.173e-279 871.0
EH2_k127_390799_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 5.039e-244 757.0
EH2_k127_390799_2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 414.0
EH2_k127_390799_3 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 301.0
EH2_k127_390799_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000001235 230.0
EH2_k127_390799_5 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000001898 190.0
EH2_k127_390799_6 adenyl ribonucleotide binding - - - 0.0000000000000000000000000000000000000000000002408 173.0
EH2_k127_390799_7 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000002295 64.0
EH2_k127_394882_0 ABC 3 transport family K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 406.0
EH2_k127_394882_1 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 393.0
EH2_k127_394882_2 AAA domain, putative AbiEii toxin, Type IV TA system K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 310.0
EH2_k127_4119375_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01908 - 6.2.1.1,6.2.1.17 0.0 1176.0
EH2_k127_4119375_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 455.0
EH2_k127_4119375_10 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 301.0
EH2_k127_4119375_11 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 302.0
EH2_k127_4119375_12 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 291.0
EH2_k127_4119375_13 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006414 263.0
EH2_k127_4119375_14 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000176 260.0
EH2_k127_4119375_15 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008164 260.0
EH2_k127_4119375_16 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000001596 203.0
EH2_k127_4119375_17 - - - - 0.000000000000000000000000000000000000000000000004044 180.0
EH2_k127_4119375_18 hydrolase K04794 - 3.1.1.29 0.0000000000000000000000000000000000000000000004271 173.0
EH2_k127_4119375_19 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000000000007459 155.0
EH2_k127_4119375_2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000845 445.0
EH2_k127_4119375_20 - - - - 0.0000000000000000000000000000000000000004829 151.0
EH2_k127_4119375_21 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000009621 151.0
EH2_k127_4119375_22 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.000000000000000000000000000000000000003681 145.0
EH2_k127_4119375_23 - - - - 0.000000000000000000000000000006095 120.0
EH2_k127_4119375_24 signal transduction protein with CBS domains - - - 0.000000000000000000000005699 115.0
EH2_k127_4119375_25 PDGLE domain K02009 - - 0.00000000000000000000002513 111.0
EH2_k127_4119375_26 PFAM CBS domain - - - 0.000000000002023 79.0
EH2_k127_4119375_27 PFAM Glucose-methanol-choline oxidoreductase, N-terminal - - - 0.00000001079 58.0
EH2_k127_4119375_28 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K02239 - - 0.0002229 48.0
EH2_k127_4119375_3 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 434.0
EH2_k127_4119375_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 382.0
EH2_k127_4119375_5 ATP-grasp domain K06914 - 6.3.4.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 377.0
EH2_k127_4119375_6 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 347.0
EH2_k127_4119375_7 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 342.0
EH2_k127_4119375_8 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 314.0
EH2_k127_4119375_9 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 312.0
EH2_k127_4141727_0 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 572.0
EH2_k127_4141727_1 Catalyzes the reversible phosphorylation of UMP to UDP K00947 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 390.0
EH2_k127_4141727_2 Molybdate transporter of MFS superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 383.0
EH2_k127_4141727_3 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.000000000000000000000000000008906 118.0
EH2_k127_4174559_0 PFAM Thiolase K00626 - 2.3.1.9 1.691e-208 652.0
EH2_k127_4174559_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 583.0
EH2_k127_4174559_10 protein conserved in archaea K09746 - - 0.0000000000000000536 81.0
EH2_k127_4174559_2 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 568.0
EH2_k127_4174559_3 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005545 349.0
EH2_k127_4174559_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 326.0
EH2_k127_4174559_5 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 304.0
EH2_k127_4174559_6 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007512 299.0
EH2_k127_4174559_7 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009293 249.0
EH2_k127_4174559_8 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000000779 221.0
EH2_k127_4174559_9 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000001255 155.0
EH2_k127_4218655_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 567.0
EH2_k127_4218655_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 464.0
EH2_k127_4218655_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004142 262.0
EH2_k127_4225345_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 514.0
EH2_k127_4225345_1 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 486.0
EH2_k127_4225345_2 DGC domain - - - 0.00000000000000000000000000000000000000005361 154.0
EH2_k127_4225345_3 PFAM regulatory protein, ArsR K21903 - - 0.0000000000000000000000000003006 119.0
EH2_k127_4225345_4 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.0000000000000000000000000004097 128.0
EH2_k127_4225345_5 DGC domain - - - 0.00000000000000000001531 96.0
EH2_k127_4240722_0 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 429.0
EH2_k127_4240722_1 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007472 268.0
EH2_k127_4240722_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000000113 169.0
EH2_k127_4240722_3 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000006163 164.0
EH2_k127_4240722_4 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000002346 147.0
EH2_k127_4240722_5 - - - - 0.0000000000000000000000000000006122 126.0
EH2_k127_4240722_6 - - - - 0.000000000000000000004658 97.0
EH2_k127_4240722_7 AAA domain - - - 0.00000000000000000000746 94.0
EH2_k127_4240722_8 Hemerythrin HHE cation binding domain - - - 0.00000000007479 70.0
EH2_k127_4290966_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1063.0
EH2_k127_4290966_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 5.053e-243 765.0
EH2_k127_4290966_2 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 409.0
EH2_k127_4290966_3 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 372.0
EH2_k127_4290966_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000262 270.0
EH2_k127_4290966_5 - - - - 0.000000000000001731 79.0
EH2_k127_4294981_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 9.523e-234 730.0
EH2_k127_4294981_1 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000001377 86.0
EH2_k127_4310907_0 Small multi-drug export protein - - - 0.000000000000000000000000000000000000001235 154.0
EH2_k127_4310907_1 - - - - 0.00000000000000000005997 92.0
EH2_k127_4411857_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.236e-297 919.0
EH2_k127_4411857_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 6.733e-236 737.0
EH2_k127_4411857_2 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001255 254.0
EH2_k127_4443733_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1692.0
EH2_k127_4443733_1 Uncharacterized protein conserved in archaea (DUF2114) - - - 8.486e-250 778.0
EH2_k127_4443733_10 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000000000003188 214.0
EH2_k127_4443733_11 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000000000000000000000000009009 186.0
EH2_k127_4443733_12 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000641 179.0
EH2_k127_4443733_13 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000000004523 153.0
EH2_k127_4443733_14 Tetratricopeptide TPR-1 - - - 0.000000000000000000000000000000000000001185 160.0
EH2_k127_4443733_15 - - - - 0.00000000000000000000000000000006008 128.0
EH2_k127_4443733_16 - - - - 0.0000000000000000000000002328 107.0
EH2_k127_4443733_17 Belongs to the UPF0235 family K09131 - - 0.0000000000000000009032 90.0
EH2_k127_4443733_2 PFAM Radical SAM domain protein K06937 - - 5.069e-243 757.0
EH2_k127_4443733_3 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 7.233e-199 625.0
EH2_k127_4443733_4 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 596.0
EH2_k127_4443733_5 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 508.0
EH2_k127_4443733_6 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 509.0
EH2_k127_4443733_7 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 412.0
EH2_k127_4443733_8 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 388.0
EH2_k127_4443733_9 COG1194 A G-specific DNA glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001546 273.0
EH2_k127_4449696_0 Heat shock 70 kDa protein K04043 - - 4.639e-294 914.0
EH2_k127_4449696_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 2.059e-249 773.0
EH2_k127_4449696_10 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 368.0
EH2_k127_4449696_11 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 346.0
EH2_k127_4449696_12 PFAM zinc iron permease K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 323.0
EH2_k127_4449696_13 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 301.0
EH2_k127_4449696_14 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 295.0
EH2_k127_4449696_15 PFAM Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003536 291.0
EH2_k127_4449696_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001217 265.0
EH2_k127_4449696_17 Protein of unknown function (DUF1646) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002341 258.0
EH2_k127_4449696_18 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002493 246.0
EH2_k127_4449696_19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000001012 239.0
EH2_k127_4449696_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 5.489e-199 631.0
EH2_k127_4449696_20 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007536 236.0
EH2_k127_4449696_21 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000002864 226.0
EH2_k127_4449696_22 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000003942 190.0
EH2_k127_4449696_23 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000001613 186.0
EH2_k127_4449696_24 Flavodoxin domain - - - 0.000000000000000000000000000000000000000000000002286 177.0
EH2_k127_4449696_25 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000001654 173.0
EH2_k127_4449696_26 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000834 171.0
EH2_k127_4449696_27 Thioesterase superfamily K02614 - - 0.0000000000000000000000000000000000000000001489 166.0
EH2_k127_4449696_28 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000005019 163.0
EH2_k127_4449696_29 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000008565 158.0
EH2_k127_4449696_3 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 533.0
EH2_k127_4449696_30 Domain of unknown function (DUF4389) - - - 0.00000000000000000000000000000000004244 137.0
EH2_k127_4449696_31 Protein of unknown function (DUF1646) - - - 0.00000000000000000000000000000000006673 136.0
EH2_k127_4449696_32 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.000000000000000000000000000002229 125.0
EH2_k127_4449696_33 - - - - 0.0000000000000000000001437 103.0
EH2_k127_4449696_34 Protease prsW family - - - 0.00000000000000007152 91.0
EH2_k127_4449696_35 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000007246 66.0
EH2_k127_4449696_36 - - - - 0.0000006805 52.0
EH2_k127_4449696_37 - - - - 0.0001603 46.0
EH2_k127_4449696_4 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 511.0
EH2_k127_4449696_5 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006726 466.0
EH2_k127_4449696_6 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 419.0
EH2_k127_4449696_7 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 379.0
EH2_k127_4449696_8 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 385.0
EH2_k127_4449696_9 UV-endonuclease UvdE K13281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 372.0
EH2_k127_450115_0 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 493.0
EH2_k127_450115_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 451.0
EH2_k127_450115_2 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 299.0
EH2_k127_450115_3 PFAM PRC-barrel domain - - - 0.00000000000000000000000000000009366 126.0
EH2_k127_450115_4 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000004033 103.0
EH2_k127_4517444_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1553.0
EH2_k127_4517444_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1210.0
EH2_k127_4517444_10 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 401.0
EH2_k127_4517444_11 TIGRFAM cell division ATPase MinD K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 382.0
EH2_k127_4517444_12 PFAM glutamate synthase alpha subunit domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 340.0
EH2_k127_4517444_13 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009553 335.0
EH2_k127_4517444_14 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 310.0
EH2_k127_4517444_15 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 313.0
EH2_k127_4517444_16 transcription termination protein NusA K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000003344 233.0
EH2_k127_4517444_17 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000003805 226.0
EH2_k127_4517444_18 protein N-acetylglucosaminyltransferase activity K12600 - - 0.0000000000000000000000000000000000000000002171 168.0
EH2_k127_4517444_19 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000000002175 161.0
EH2_k127_4517444_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1043.0
EH2_k127_4517444_20 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.0000000000000000000000000000001242 126.0
EH2_k127_4517444_21 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000007633 124.0
EH2_k127_4517444_22 Phosphate-starvation-inducible E - - - 0.00000000000000000000000000001263 122.0
EH2_k127_4517444_23 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.0000000000000000000002879 98.0
EH2_k127_4517444_24 Tetratricopeptide repeat K12600 - - 0.000000000000000004115 93.0
EH2_k127_4517444_25 - - - - 0.000000000000000007756 91.0
EH2_k127_4517444_26 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000008043 84.0
EH2_k127_4517444_27 Roadblock LC7 family protein K06945,K07131 - - 0.000000000004664 71.0
EH2_k127_4517444_28 - - - - 0.000000006403 64.0
EH2_k127_4517444_29 - - - - 0.000006097 50.0
EH2_k127_4517444_3 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 9.495e-300 923.0
EH2_k127_4517444_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 596.0
EH2_k127_4517444_5 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 580.0
EH2_k127_4517444_6 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 580.0
EH2_k127_4517444_7 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 512.0
EH2_k127_4517444_8 Belongs to the glutamate synthase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004739 491.0
EH2_k127_4517444_9 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 413.0
EH2_k127_4518318_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 610.0
EH2_k127_4518318_1 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 552.0
EH2_k127_4518318_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000001232 243.0
EH2_k127_4518318_3 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000001771 198.0
EH2_k127_4617399_0 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 379.0
EH2_k127_4617399_1 PFAM Tetratricopeptide - - - 0.00000000000006756 78.0
EH2_k127_4639523_0 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 515.0
EH2_k127_4639523_1 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 453.0
EH2_k127_4639523_10 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000008481 217.0
EH2_k127_4639523_11 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000000000000000174 157.0
EH2_k127_4639523_12 - - - - 0.0000000000000000000000000000000001689 137.0
EH2_k127_4639523_13 4Fe-4S dicluster domain - - - 0.0000000000000000002417 89.0
EH2_k127_4639523_14 structural constituent of ribosome K02962 - - 0.0000000000000001664 80.0
EH2_k127_4639523_15 - - - - 0.0001491 49.0
EH2_k127_4639523_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008512 439.0
EH2_k127_4639523_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 429.0
EH2_k127_4639523_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006354 376.0
EH2_k127_4639523_5 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 357.0
EH2_k127_4639523_6 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 340.0
EH2_k127_4639523_7 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000002279 257.0
EH2_k127_4639523_8 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000002635 239.0
EH2_k127_4639523_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000001635 221.0
EH2_k127_4841601_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1285.0
EH2_k127_4841601_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 3.377e-235 736.0
EH2_k127_4841601_10 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 301.0
EH2_k127_4841601_11 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001619 259.0
EH2_k127_4841601_12 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000004059 252.0
EH2_k127_4841601_13 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000000000000000000000000001441 228.0
EH2_k127_4841601_14 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000855 221.0
EH2_k127_4841601_15 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000007492 216.0
EH2_k127_4841601_16 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000000000005097 199.0
EH2_k127_4841601_17 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000004079 185.0
EH2_k127_4841601_18 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000000141 160.0
EH2_k127_4841601_19 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000000000000916 150.0
EH2_k127_4841601_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.718e-230 720.0
EH2_k127_4841601_20 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000009123 138.0
EH2_k127_4841601_21 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000000000000000000001427 138.0
EH2_k127_4841601_22 HEAT repeats - - - 0.00000000000000000000000005573 113.0
EH2_k127_4841601_23 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000002383 90.0
EH2_k127_4841601_24 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000002951 79.0
EH2_k127_4841601_25 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000003762 77.0
EH2_k127_4841601_26 PBS lyase HEAT-like repeat - - - 0.0000000007154 66.0
EH2_k127_4841601_27 - - - - 0.000000002484 59.0
EH2_k127_4841601_28 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000001545 57.0
EH2_k127_4841601_3 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 609.0
EH2_k127_4841601_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 568.0
EH2_k127_4841601_5 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 458.0
EH2_k127_4841601_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 390.0
EH2_k127_4841601_7 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007721 359.0
EH2_k127_4841601_8 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 338.0
EH2_k127_4841601_9 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 316.0
EH2_k127_4998790_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 524.0
EH2_k127_4998790_1 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000542 174.0
EH2_k127_4998790_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.0000000000000000000004238 99.0
EH2_k127_4998790_3 Collagenase K08303 - - 0.000000002986 61.0
EH2_k127_5007142_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0 1021.0
EH2_k127_5007142_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 4.364e-245 787.0
EH2_k127_5007142_10 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000000000000000000001134 158.0
EH2_k127_5007142_11 SigmaK-factor processing regulatory protein BofA - - - 0.00000000001978 67.0
EH2_k127_5007142_12 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0001187 48.0
EH2_k127_5007142_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 3.828e-239 750.0
EH2_k127_5007142_3 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 580.0
EH2_k127_5007142_4 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 449.0
EH2_k127_5007142_5 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 349.0
EH2_k127_5007142_6 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 315.0
EH2_k127_5007142_7 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005744 268.0
EH2_k127_5007142_8 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000002333 228.0
EH2_k127_5007142_9 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000004522 171.0
EH2_k127_50083_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 539.0
EH2_k127_50083_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 425.0
EH2_k127_50083_2 - K03686 - - 0.00000000000000000002527 91.0
EH2_k127_5155489_0 KH, type 1, domain K07041 - - 0.0 1074.0
EH2_k127_5155489_1 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 415.0
EH2_k127_5155489_10 Involved in protein export. The function of the beta subunit is - GO:0003674,GO:0005085,GO:0005086,GO:0005488,GO:0005515,GO:0008150,GO:0019899,GO:0051020,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000006237 72.0
EH2_k127_5155489_2 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 386.0
EH2_k127_5155489_3 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 366.0
EH2_k127_5155489_4 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 312.0
EH2_k127_5155489_5 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 307.0
EH2_k127_5155489_6 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 314.0
EH2_k127_5155489_7 COG0589 Universal stress protein UspA and related nucleotide-binding - - - 0.000000000000000000000000000000000000000000007506 168.0
EH2_k127_5155489_8 - - - - 0.000000000000000000000000000006971 122.0
EH2_k127_5155489_9 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000009246 74.0
EH2_k127_5167153_0 PFAM type II secretion system protein E K07332 - - 3.747e-276 866.0
EH2_k127_5167153_1 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 379.0
EH2_k127_5167153_2 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 376.0
EH2_k127_5167153_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000001327 118.0
EH2_k127_5167153_4 PFAM Roadblock LC7 family protein - - - 0.00000000000000237 78.0
EH2_k127_5173126_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.969e-221 694.0
EH2_k127_5173126_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 537.0
EH2_k127_5173126_2 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 328.0
EH2_k127_5173126_3 - - - - 0.00000000000000000000000000000000000000000008211 164.0
EH2_k127_5173126_4 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000003416 144.0
EH2_k127_5173126_5 Ferritin-like domain K02217 - 1.16.3.2 0.000000000000000000000000000001072 123.0
EH2_k127_5215237_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 586.0
EH2_k127_5215237_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 435.0
EH2_k127_5215237_2 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 330.0
EH2_k127_5215237_3 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000007893 186.0
EH2_k127_5215237_4 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000006871 181.0
EH2_k127_5215237_5 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000008689 164.0
EH2_k127_5215237_6 Nitrogen regulatory protein P-II K04751 - - 0.0000000000000000000000000000000000000004699 154.0
EH2_k127_5215237_7 PFAM Metallophosphoesterase - - - 0.0000000000000000000000000000004036 130.0
EH2_k127_5215237_8 - - - - 0.00000000000000000000000000007631 118.0
EH2_k127_5215237_9 Elongator protein 3 MiaB NifB - - - 0.000000001158 59.0
EH2_k127_5226112_0 PFAM dihydropteroate synthase, DHPS - - - 4.126e-200 634.0
EH2_k127_5226112_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 603.0
EH2_k127_5226112_10 oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000004707 135.0
EH2_k127_5226112_11 Protein of unknown function (DUF2769) - - - 0.00000000000000000000005177 102.0
EH2_k127_5226112_2 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 584.0
EH2_k127_5226112_3 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 435.0
EH2_k127_5226112_4 His Kinase A (phospho-acceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 346.0
EH2_k127_5226112_5 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 293.0
EH2_k127_5226112_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003543 280.0
EH2_k127_5226112_7 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001512 257.0
EH2_k127_5226112_8 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000006465 204.0
EH2_k127_5226112_9 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.000000000000000000000000000000000000000000000000003599 183.0
EH2_k127_5237617_0 LOR SDH bifunctional enzyme conserved - - - 3.731e-196 618.0
EH2_k127_5237617_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 405.0
EH2_k127_5237617_2 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.0000000000000000000000000000000000000000000000000000005209 199.0
EH2_k127_5237617_3 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000006097 136.0
EH2_k127_5400137_0 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 358.0
EH2_k127_5400137_1 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 351.0
EH2_k127_5400137_2 ABC-type tungstate transport system, periplasmic component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003983 259.0
EH2_k127_5432065_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 7.105e-293 903.0
EH2_k127_5432065_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 5.321e-271 844.0
EH2_k127_5432065_10 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 433.0
EH2_k127_5432065_11 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 419.0
EH2_k127_5432065_12 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 422.0
EH2_k127_5432065_13 methanogenesis marker protein 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 408.0
EH2_k127_5432065_14 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 313.0
EH2_k127_5432065_15 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 298.0
EH2_k127_5432065_16 cytidyltransferase-related domain K00952 - 2.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001583 280.0
EH2_k127_5432065_17 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000459 198.0
EH2_k127_5432065_18 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000006967 193.0
EH2_k127_5432065_19 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000004809 184.0
EH2_k127_5432065_2 AAA-like domain K06915 - - 5.807e-221 696.0
EH2_k127_5432065_20 - - - - 0.0000000000000000000000000000000000000000000006629 168.0
EH2_k127_5432065_21 - - - - 0.00000000000000000000000000000007367 130.0
EH2_k127_5432065_22 - - - - 0.00000000000000000000000001382 111.0
EH2_k127_5432065_23 - - - - 0.0000000000002768 75.0
EH2_k127_5432065_24 - K06868 - 2.5.1.73 0.0000001494 57.0
EH2_k127_5432065_3 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 8.598e-218 681.0
EH2_k127_5432065_4 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 590.0
EH2_k127_5432065_5 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006374 559.0
EH2_k127_5432065_6 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 549.0
EH2_k127_5432065_7 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 517.0
EH2_k127_5432065_8 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 430.0
EH2_k127_5432065_9 MviN-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 437.0
EH2_k127_5446960_0 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000000000000000000000000000000000000000000000000000001789 222.0
EH2_k127_5446960_1 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.00000000000000000000000000000000000000000000000000001873 192.0
EH2_k127_5446960_2 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.0000000000000000000000000000000000006088 142.0
EH2_k127_5446960_3 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000000000000000001491 130.0
EH2_k127_5446960_4 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000009897 108.0
EH2_k127_5446960_5 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.000000000000000000000001822 105.0
EH2_k127_5446960_6 Domain of unknown function (DUF4040) - - - 0.000000000000000000000006742 103.0
EH2_k127_5446960_7 Membrane bound hydrogenase - - - 0.0000000000000002588 81.0
EH2_k127_5527122_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.403e-245 764.0
EH2_k127_5527122_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 509.0
EH2_k127_5527122_10 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005468 244.0
EH2_k127_5527122_11 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000001017 236.0
EH2_k127_5527122_12 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000000002717 230.0
EH2_k127_5527122_13 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000004522 225.0
EH2_k127_5527122_14 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000003241 218.0
EH2_k127_5527122_15 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000001488 221.0
EH2_k127_5527122_16 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000000000000000000008005 212.0
EH2_k127_5527122_17 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000000000000000000001523 211.0
EH2_k127_5527122_18 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000003351 201.0
EH2_k127_5527122_19 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000000000000000000000006321 187.0
EH2_k127_5527122_2 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 474.0
EH2_k127_5527122_20 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000000000000004762 176.0
EH2_k127_5527122_21 PFAM sigma-70 region 4 domain protein K09714 - - 0.000000000000000000000000000000000000000000000002421 176.0
EH2_k127_5527122_22 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000005656 166.0
EH2_k127_5527122_23 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000000000000000000704 164.0
EH2_k127_5527122_24 PFAM Ribosomal protein K02912 - - 0.0000000000000000000000000000000000321 140.0
EH2_k127_5527122_25 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.000000000000000000000002036 102.0
EH2_k127_5527122_26 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000023 106.0
EH2_k127_5527122_27 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000000000000004649 103.0
EH2_k127_5527122_28 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000000005169 93.0
EH2_k127_5527122_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 361.0
EH2_k127_5527122_4 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 349.0
EH2_k127_5527122_5 Binds the lower part of the 30S subunit head K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 347.0
EH2_k127_5527122_6 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 334.0
EH2_k127_5527122_7 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 297.0
EH2_k127_5527122_8 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000008514 251.0
EH2_k127_5527122_9 TIGRFAM ribosomal protein L30P K02907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003785 243.0
EH2_k127_5548976_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 574.0
EH2_k127_5548976_1 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 344.0
EH2_k127_5548976_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000003056 178.0
EH2_k127_5548976_3 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000000001519 162.0
EH2_k127_5554990_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1353.0
EH2_k127_5554990_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.11e-309 960.0
EH2_k127_5554990_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007874 602.0
EH2_k127_5554990_3 V-type ATP synthase, subunit I K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 313.0
EH2_k127_5554990_4 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000007382 174.0
EH2_k127_5554990_5 ATP synthase subunit K K02124 - - 0.0000000000000000000000000000000000000000002896 163.0
EH2_k127_5554990_6 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000003492 163.0
EH2_k127_5623621_0 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 337.0
EH2_k127_5623621_1 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 321.0
EH2_k127_5662616_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 552.0
EH2_k127_5662616_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 505.0
EH2_k127_5662616_2 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 453.0
EH2_k127_5662616_3 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 384.0
EH2_k127_5662616_4 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 374.0
EH2_k127_5662616_5 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 311.0
EH2_k127_5662616_6 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001936 243.0
EH2_k127_5662616_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000186 213.0
EH2_k127_5662616_8 Anaerobic ribonucleoside-triphosphate reductase - - - 0.000000000000000000000000000000000000000000000000000000001282 202.0
EH2_k127_5662616_9 Domain of unknown function (DUF1858) - - - 0.00000000000000000000000003061 108.0
EH2_k127_5769958_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1219.0
EH2_k127_5769958_1 DEAD DEAH box helicase K06877 - - 1.362e-289 907.0
EH2_k127_5769958_10 DNA methylase K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 444.0
EH2_k127_5769958_11 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 379.0
EH2_k127_5769958_12 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 333.0
EH2_k127_5769958_13 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003734 281.0
EH2_k127_5769958_14 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001368 249.0
EH2_k127_5769958_15 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002918 253.0
EH2_k127_5769958_16 Alpha/beta hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000001874 214.0
EH2_k127_5769958_17 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000009985 196.0
EH2_k127_5769958_18 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.000000000000000000000000000000000000000000000000000005693 196.0
EH2_k127_5769958_19 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.00000000000000000000000000000000000000000000000000396 186.0
EH2_k127_5769958_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 3.616e-250 778.0
EH2_k127_5769958_20 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000001305 185.0
EH2_k127_5769958_21 RNase_H superfamily K07502 - - 0.00000000000000006654 81.0
EH2_k127_5769958_3 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 4.393e-249 778.0
EH2_k127_5769958_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 2.413e-247 775.0
EH2_k127_5769958_5 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 3.17e-212 665.0
EH2_k127_5769958_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 540.0
EH2_k127_5769958_7 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 502.0
EH2_k127_5769958_8 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 458.0
EH2_k127_5769958_9 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 449.0
EH2_k127_5772233_0 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 391.0
EH2_k127_5772233_1 Response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000001351 180.0
EH2_k127_5772233_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000486 174.0
EH2_k127_5782104_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 540.0
EH2_k127_5782104_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 518.0
EH2_k127_5782104_2 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 451.0
EH2_k127_5782104_3 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 413.0
EH2_k127_5782104_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 341.0
EH2_k127_5782104_5 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001301 290.0
EH2_k127_5782104_6 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000007135 224.0
EH2_k127_5782104_7 PFAM Radical SAM - - - 0.0000000003163 63.0
EH2_k127_5782104_8 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000002192 58.0
EH2_k127_60901_0 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005555 250.0
EH2_k127_60901_1 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000000007339 171.0
EH2_k127_60901_2 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000000000000000000000002504 155.0
EH2_k127_60901_3 TIGRFAM C_GCAxxG_C_C family - - - 0.000000000000000000000000001576 117.0
EH2_k127_60901_4 sister chromatid segregation - - - 0.0004807 51.0
EH2_k127_6201101_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 2.491e-229 720.0
EH2_k127_6201101_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 474.0
EH2_k127_6201101_10 PFAM Ribosomal protein S27E K02978 - - 0.000000000000000000000001448 103.0
EH2_k127_6201101_11 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000006027 73.0
EH2_k127_6201101_2 Translation initiation factor 2 alpha subunit K03237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009585 357.0
EH2_k127_6201101_3 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 296.0
EH2_k127_6201101_4 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009692 285.0
EH2_k127_6201101_5 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000002626 216.0
EH2_k127_6201101_6 Belongs to the UPF0179 family K09730 - - 0.000000000000000000000000000000000000000000000000000000006734 201.0
EH2_k127_6201101_7 binds to the 23S rRNA K02929 - - 0.00000000000000000000000000000000000000000000006846 169.0
EH2_k127_6201101_8 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000831 142.0
EH2_k127_6201101_9 metal-binding protein - - - 0.00000000000000000000000006648 109.0
EH2_k127_6207348_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.127e-220 698.0
EH2_k127_6207348_1 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 4.142e-197 619.0
EH2_k127_6207348_10 archaeal Zn-finger protein - - - 0.000001371 51.0
EH2_k127_6207348_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 434.0
EH2_k127_6207348_3 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 348.0
EH2_k127_6207348_4 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000003666 183.0
EH2_k127_6207348_5 - - - - 0.000000000000000000000000000000001109 140.0
EH2_k127_6207348_6 - - - - 0.000000000000000000000000000001389 125.0
EH2_k127_6207348_7 PFAM Uncharacterised protein family (UPF0153) K06940 - - 0.00000000000000000000000000007276 125.0
EH2_k127_6207348_8 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000001696 107.0
EH2_k127_6207348_9 - - - - 0.000000000000000005051 90.0
EH2_k127_6212657_0 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 541.0
EH2_k127_6212657_1 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 292.0
EH2_k127_6212657_2 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 284.0
EH2_k127_6223353_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1184.0
EH2_k127_6223353_1 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 4.751e-275 861.0
EH2_k127_6223353_10 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000009067 239.0
EH2_k127_6223353_11 TIGRFAM methionine-R-sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000002094 207.0
EH2_k127_6223353_12 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000000000000000002782 201.0
EH2_k127_6223353_13 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000002047 154.0
EH2_k127_6223353_14 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000001694 134.0
EH2_k127_6223353_15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000001257 114.0
EH2_k127_6223353_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 8.44e-218 684.0
EH2_k127_6223353_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.533e-198 626.0
EH2_k127_6223353_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.235e-196 625.0
EH2_k127_6223353_5 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 451.0
EH2_k127_6223353_6 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 323.0
EH2_k127_6223353_7 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 322.0
EH2_k127_6223353_8 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 319.0
EH2_k127_6223353_9 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 292.0
EH2_k127_6246638_0 ABC 3 transport family K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 388.0
EH2_k127_6246638_1 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 380.0
EH2_k127_6246638_2 AAA domain, putative AbiEii toxin, Type IV TA system K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 316.0
EH2_k127_6246638_3 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003663 244.0
EH2_k127_6246638_4 Protein of unknown function (DUF2769) - - - 0.000007049 49.0
EH2_k127_6284210_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1122.0
EH2_k127_6284210_1 Required for chromosome condensation and partitioning K03529 - - 3.304e-267 848.0
EH2_k127_6284210_10 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 390.0
EH2_k127_6284210_11 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 333.0
EH2_k127_6284210_12 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 327.0
EH2_k127_6284210_13 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 308.0
EH2_k127_6284210_14 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001786 264.0
EH2_k127_6284210_15 methyltransferase small K07579 - - 0.0000000000000000000000000000000000000000000000000000000000000000003599 236.0
EH2_k127_6284210_16 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000003722 210.0
EH2_k127_6284210_17 - - - - 0.0000000000000000000000000000000000000000000000000000000004093 206.0
EH2_k127_6284210_18 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000000000000008659 168.0
EH2_k127_6284210_19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000005231 154.0
EH2_k127_6284210_2 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 4.179e-249 778.0
EH2_k127_6284210_20 - - - - 0.00000000000000000000002764 110.0
EH2_k127_6284210_21 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000433 98.0
EH2_k127_6284210_22 - - - - 0.000000000000000005592 89.0
EH2_k127_6284210_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 7.992e-215 674.0
EH2_k127_6284210_4 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005764 465.0
EH2_k127_6284210_5 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 451.0
EH2_k127_6284210_6 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 416.0
EH2_k127_6284210_7 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 417.0
EH2_k127_6284210_8 Archaeal Nre, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 418.0
EH2_k127_6284210_9 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 400.0
EH2_k127_6320905_0 Belongs to the MCM family K10726 - - 5.431e-302 940.0
EH2_k127_6320905_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 499.0
EH2_k127_6320905_2 DEAD DEAH box helicase domain protein K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 413.0
EH2_k127_6320905_3 PFAM TatD-related deoxyribonuclease K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 374.0
EH2_k127_6320905_4 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 302.0
EH2_k127_6320905_5 PFAM metallophosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004153 278.0
EH2_k127_6320905_6 protein conserved in archaea K09746 - - 0.00000000000000000000000000000000001454 146.0
EH2_k127_6320905_7 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000000008284 131.0
EH2_k127_6320905_8 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000008795 112.0
EH2_k127_6320905_9 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.00000000000000002189 83.0
EH2_k127_6321701_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 400.0
EH2_k127_6321701_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000001088 227.0
EH2_k127_6321701_2 WLM domain K07043 - - 0.000000000000000000000000000000000000000000001743 167.0
EH2_k127_6321701_3 WLM domain K07043 - - 0.00000000000000000000000764 107.0
EH2_k127_6321701_4 UbiA prenyltransferase family - - - 0.000005778 50.0
EH2_k127_6329114_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 3.215e-211 675.0
EH2_k127_6329114_1 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 518.0
EH2_k127_6329114_10 DNA polymerase activity K02319 - 2.7.7.7 0.00000000000000000000005056 107.0
EH2_k127_6329114_11 - - - - 0.0000000000000004637 79.0
EH2_k127_6329114_12 - - - - 0.0000001102 58.0
EH2_k127_6329114_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009724 432.0
EH2_k127_6329114_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 440.0
EH2_k127_6329114_4 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 425.0
EH2_k127_6329114_5 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 417.0
EH2_k127_6329114_6 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 317.0
EH2_k127_6329114_7 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000365 287.0
EH2_k127_6329114_8 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000005366 158.0
EH2_k127_6329114_9 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000008536 119.0
EH2_k127_6348346_0 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005518 556.0
EH2_k127_6348346_1 - K14093 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002212 246.0
EH2_k127_6348346_2 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000006925 150.0
EH2_k127_6348346_3 Small multi-drug export protein - - - 0.0000000000000000000000000000000003694 140.0
EH2_k127_6348346_4 Predicted membrane protein (DUF2107) K14096 - - 0.0000000000000000000003298 100.0
EH2_k127_6348346_5 Predicted membrane protein (DUF2109) K14094 - - 0.0000000000000000003284 91.0
EH2_k127_6348346_6 Predicted membrane protein (DUF2108) K14095 - - 0.00000000000001318 77.0
EH2_k127_6348346_7 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.00000002273 56.0
EH2_k127_6356336_0 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 341.0
EH2_k127_6356336_1 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000001078 231.0
EH2_k127_6356336_2 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000005305 184.0
EH2_k127_6356336_3 Phosphate transport regulator K07220 - - 0.000000000000000000000004708 104.0
EH2_k127_6374791_0 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 436.0
EH2_k127_6374791_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000005458 264.0
EH2_k127_6374791_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000000000000000000000000004582 229.0
EH2_k127_6374791_3 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000003101 211.0
EH2_k127_6412142_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 1.146e-264 828.0
EH2_k127_6412142_1 Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 363.0
EH2_k127_6412142_2 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 343.0
EH2_k127_6412142_3 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 303.0
EH2_k127_6412142_4 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003238 273.0
EH2_k127_6412142_5 PFAM Amidohydrolase 2 K07045 - - 0.000000000000000000000000000000000000000000000000000000000000008473 226.0
EH2_k127_6412142_6 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000002944 171.0
EH2_k127_6412142_7 Putative metal-binding motif - - - 0.000000000003191 79.0
EH2_k127_6412142_8 IgA Peptidase M64 - - - 0.000001624 61.0
EH2_k127_6412142_9 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00002263 52.0
EH2_k127_6431563_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1748.0
EH2_k127_6431563_1 PFAM ABC transporter K00400 - - 1.021e-282 875.0
EH2_k127_6431563_10 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 538.0
EH2_k127_6431563_11 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 454.0
EH2_k127_6431563_12 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 440.0
EH2_k127_6431563_13 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 406.0
EH2_k127_6431563_14 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 392.0
EH2_k127_6431563_15 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 387.0
EH2_k127_6431563_16 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 382.0
EH2_k127_6431563_17 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 384.0
EH2_k127_6431563_18 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007174 374.0
EH2_k127_6431563_19 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 361.0
EH2_k127_6431563_2 COG0464 ATPases of the AAA class K13525 - - 1.216e-271 857.0
EH2_k127_6431563_20 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 357.0
EH2_k127_6431563_21 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 347.0
EH2_k127_6431563_22 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 324.0
EH2_k127_6431563_23 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 317.0
EH2_k127_6431563_24 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 297.0
EH2_k127_6431563_25 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 297.0
EH2_k127_6431563_26 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008059 254.0
EH2_k127_6431563_27 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000001874 248.0
EH2_k127_6431563_28 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001312 232.0
EH2_k127_6431563_29 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.000000000000000000000000000000000000000000000000000000000005563 213.0
EH2_k127_6431563_3 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.394e-216 677.0
EH2_k127_6431563_30 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000003346 188.0
EH2_k127_6431563_31 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.0000000000000000000000000000000000000000000000000004757 188.0
EH2_k127_6431563_32 PAS domain - - - 0.0000000000000000000000000000000000000000000000002601 186.0
EH2_k127_6431563_33 PFAM Glycosyl transferase, group 1 K06338,K12995 - 2.4.1.348 0.0000000000000000000000000000000000000000000000007065 189.0
EH2_k127_6431563_34 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00000000000000000000000000000000000000000000002058 177.0
EH2_k127_6431563_35 Protein of unknown function (DUF432) K09149 - - 0.000000000000000000000000000000000000000001164 166.0
EH2_k127_6431563_36 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000002424 120.0
EH2_k127_6431563_37 - - - - 0.0000000000000000000003776 104.0
EH2_k127_6431563_38 HEAT repeat - - - 0.00000000000000000002284 98.0
EH2_k127_6431563_39 Histidine kinase-like ATPases - - - 0.000000006383 68.0
EH2_k127_6431563_4 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 5.382e-207 651.0
EH2_k127_6431563_5 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 3.496e-196 623.0
EH2_k127_6431563_6 Starch synthase catalytic domain - - - 1.544e-194 614.0
EH2_k127_6431563_7 TIGRFAM UbiD family - - - 5.247e-194 612.0
EH2_k127_6431563_8 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 606.0
EH2_k127_6431563_9 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 550.0
EH2_k127_6441778_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.76e-231 721.0
EH2_k127_6441778_1 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 421.0
EH2_k127_6441778_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000003467 201.0
EH2_k127_6441778_3 - - - - 0.0000000000000000000000000001561 121.0
EH2_k127_6497193_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 548.0
EH2_k127_6497193_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 483.0
EH2_k127_6497193_10 Pas domain - - - 0.0000000000000000000000000000000000000000000000000000001448 211.0
EH2_k127_6497193_11 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000001816 199.0
EH2_k127_6497193_12 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000005958 195.0
EH2_k127_6497193_13 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.00000000000000000000000000000000000004253 145.0
EH2_k127_6497193_14 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000003203 51.0
EH2_k127_6497193_15 - - - - 0.0001621 46.0
EH2_k127_6497193_2 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007234 365.0
EH2_k127_6497193_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009677 367.0
EH2_k127_6497193_4 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 347.0
EH2_k127_6497193_5 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 339.0
EH2_k127_6497193_6 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 333.0
EH2_k127_6497193_7 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 301.0
EH2_k127_6497193_8 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 295.0
EH2_k127_6497193_9 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000005588 220.0
EH2_k127_6540978_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 582.0
EH2_k127_6540978_1 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 331.0
EH2_k127_6540978_2 amino acid K16263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001587 274.0
EH2_k127_6540978_3 small multi-drug export - - - 0.000000000000000000000000000000000000000000000000000005557 195.0
EH2_k127_6540978_4 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000002305 155.0
EH2_k127_6540978_5 SpoVT / AbrB like domain - - - 0.00000000000000000000000006173 111.0
EH2_k127_6540978_6 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000005371 88.0
EH2_k127_6540978_7 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000001841 83.0
EH2_k127_6544701_0 Belongs to the RtcB family K14415 - 6.5.1.3 1.366e-224 704.0
EH2_k127_6544701_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 368.0
EH2_k127_6544701_10 - - - - 0.0000000000000000002349 91.0
EH2_k127_6544701_2 PFAM ABC transporter K16786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000279 242.0
EH2_k127_6544701_3 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.00000000000000000000000000000000000000000000000000000000000000000007982 238.0
EH2_k127_6544701_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000003085 231.0
EH2_k127_6544701_5 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.00000000000000000000000000000000000000000000000000000000005895 207.0
EH2_k127_6544701_6 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000004319 184.0
EH2_k127_6544701_7 Protein of unknown function (DUF2551) - - - 0.000000000000000000000000000000000009123 138.0
EH2_k127_6544701_8 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000000000000000000000001116 134.0
EH2_k127_6544701_9 Involved in protein export K03074 - - 0.00000000000000000000000000001461 122.0
EH2_k127_6553608_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000102 274.0
EH2_k127_6553608_1 O-methyltransferase K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004286 265.0
EH2_k127_6553608_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000001817 238.0
EH2_k127_6553608_3 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000299 226.0
EH2_k127_6553608_4 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000005804 180.0
EH2_k127_6553608_5 - - - - 0.00000000000000000000000000000000000000000000006708 174.0
EH2_k127_6553608_6 transcription activator, effector binding - - - 0.000000000000000000000000000000000000000000007358 169.0
EH2_k127_6553957_0 PFAM aminotransferase class V - - - 5.732e-204 642.0
EH2_k127_6553957_1 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 599.0
EH2_k127_6553957_10 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001855 256.0
EH2_k127_6553957_11 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000001663 222.0
EH2_k127_6553957_12 PFAM Ribonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000001241 211.0
EH2_k127_6553957_13 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000002565 196.0
EH2_k127_6553957_14 Yip1 domain - - - 0.0000000000000000000000000000000000000000000005216 174.0
EH2_k127_6553957_15 SMART Excinuclease ABC, C subunit - - - 0.0000000000000000000000000000000000000000008787 160.0
EH2_k127_6553957_16 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000001216 134.0
EH2_k127_6553957_17 Domain of unknown function (DUF1805) - - - 0.000000000000000000000000000007997 121.0
EH2_k127_6553957_2 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 541.0
EH2_k127_6553957_3 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 539.0
EH2_k127_6553957_4 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005784 490.0
EH2_k127_6553957_5 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 318.0
EH2_k127_6553957_6 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 311.0
EH2_k127_6553957_7 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 309.0
EH2_k127_6553957_8 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000899 261.0
EH2_k127_6553957_9 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000018 251.0
EH2_k127_6621342_0 Protein-export membrane protein SecD K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 593.0
EH2_k127_6621342_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000002507 208.0
EH2_k127_6621342_2 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000006871 135.0
EH2_k127_6621342_3 Involved in protein export K03074 - - 0.0000000002613 61.0
EH2_k127_6668662_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 403.0
EH2_k127_6668662_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 381.0
EH2_k127_6916669_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1105.0
EH2_k127_6916669_1 DEAD DEAH box helicase domain protein K10896 - - 3.52e-301 941.0
EH2_k127_6916669_10 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.000000000000000000000000000000000000000000001751 168.0
EH2_k127_6916669_11 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000223 141.0
EH2_k127_6916669_12 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.00000000000000000000000000000000009055 137.0
EH2_k127_6916669_13 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000001528 104.0
EH2_k127_6916669_14 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000006063 81.0
EH2_k127_6916669_2 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 7.296e-262 820.0
EH2_k127_6916669_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 5.932e-220 701.0
EH2_k127_6916669_4 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 502.0
EH2_k127_6916669_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 295.0
EH2_k127_6916669_6 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001448 261.0
EH2_k127_6916669_7 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000001067 253.0
EH2_k127_6916669_8 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000002628 211.0
EH2_k127_6916669_9 TfuA-like protein - - - 0.00000000000000000000000000000000000000000000008844 177.0
EH2_k127_6949380_0 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007721 434.0
EH2_k127_6949380_1 - - - - 0.000000000001192 78.0
EH2_k127_6962009_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.768e-231 720.0
EH2_k127_6962009_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 9.259e-226 704.0
EH2_k127_6962009_2 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 602.0
EH2_k127_6962009_3 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 312.0
EH2_k127_6962009_4 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 295.0
EH2_k127_6962009_5 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000002708 202.0
EH2_k127_6962009_6 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000002588 187.0
EH2_k127_6962009_7 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000000000005094 115.0
EH2_k127_6962009_8 PFAM Nitroreductase - - - 0.0000000000003798 70.0
EH2_k127_6962009_9 PFAM Transcriptional regulator PadR-like family - - - 0.0000001081 63.0
EH2_k127_7209524_0 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 2.967e-245 766.0
EH2_k127_7209524_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 1.119e-199 632.0
EH2_k127_7209524_10 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000003316 222.0
EH2_k127_7209524_11 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000005251 224.0
EH2_k127_7209524_12 Helix-turn-helix domain protein K03627 - - 0.000000000000000000000000000000000000000000000005338 177.0
EH2_k127_7209524_13 TspO/MBR family K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000002726 174.0
EH2_k127_7209524_14 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000009055 170.0
EH2_k127_7209524_15 protein possibly involved in aromatic compounds catabolism K02614 - - 0.00000000000000000000000153 108.0
EH2_k127_7209524_16 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000001455 62.0
EH2_k127_7209524_17 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000181 55.0
EH2_k127_7209524_2 PFAM amine oxidase - - - 2.128e-195 617.0
EH2_k127_7209524_3 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 602.0
EH2_k127_7209524_4 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 609.0
EH2_k127_7209524_5 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 405.0
EH2_k127_7209524_6 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 378.0
EH2_k127_7209524_7 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004664 315.0
EH2_k127_7209524_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001024 284.0
EH2_k127_7209524_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000002276 229.0
EH2_k127_7227177_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 1.492e-235 737.0
EH2_k127_7227177_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 1.073e-198 623.0
EH2_k127_7227177_2 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000005429 93.0
EH2_k127_7227177_3 Hsp20/alpha crystallin family K13993 - - 0.00000000004511 70.0
EH2_k127_7234994_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 3.26e-244 761.0
EH2_k127_7234994_1 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.000000000000000000000000000000000000000003576 158.0
EH2_k127_7234994_2 - - - - 0.00000000000000003474 83.0
EH2_k127_7234994_3 - - - - 0.00000000003477 64.0
EH2_k127_7238503_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1260.0
EH2_k127_7238503_1 PFAM CBS domain - - - 2.436e-234 734.0
EH2_k127_7238503_10 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001194 252.0
EH2_k127_7238503_11 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18023 - 1.12.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000007906 244.0
EH2_k127_7238503_12 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000000000007716 231.0
EH2_k127_7238503_13 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000003716 234.0
EH2_k127_7238503_14 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000000000000000000000000000000000000000000000000000000006395 222.0
EH2_k127_7238503_15 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.00000000000000000000000000000000000000000000000000000000000001042 223.0
EH2_k127_7238503_16 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.0000000000000000000000000000000000000000000000000000000000001352 216.0
EH2_k127_7238503_17 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.000000000000000000000000000000000000000000000000007195 183.0
EH2_k127_7238503_18 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000000000000000000000000000001835 181.0
EH2_k127_7238503_19 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000002 170.0
EH2_k127_7238503_2 Proton-conducting membrane transporter K05568 - - 1.813e-211 668.0
EH2_k127_7238503_20 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000001952 164.0
EH2_k127_7238503_21 - - - - 0.000000000000000000000000000000000000006229 151.0
EH2_k127_7238503_22 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.000000000000000000000000000000000007491 140.0
EH2_k127_7238503_23 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000000000000000001091 127.0
EH2_k127_7238503_24 zinc finger, SWIM - - - 0.000000000000000000000000000002587 123.0
EH2_k127_7238503_25 - - - - 0.000000000000000000000000002976 116.0
EH2_k127_7238503_26 Domain of unknown function (DUF4040) - - - 0.0000000000000000000002097 99.0
EH2_k127_7238503_27 Membrane bound hydrogenase - - - 0.0000000000000000000004137 98.0
EH2_k127_7238503_28 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000008018 104.0
EH2_k127_7238503_29 Multiple resistance and pH regulation protein F K05570 - - 0.00000000000000000003474 92.0
EH2_k127_7238503_3 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 2.498e-196 618.0
EH2_k127_7238503_30 - - - - 0.00000000000002255 79.0
EH2_k127_7238503_31 - - - - 0.0000000002149 65.0
EH2_k127_7238503_32 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.0000000002171 64.0
EH2_k127_7238503_33 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000001262 56.0
EH2_k127_7238503_4 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 8.301e-196 620.0
EH2_k127_7238503_5 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 427.0
EH2_k127_7238503_6 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 383.0
EH2_k127_7238503_7 RNA methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000531 353.0
EH2_k127_7238503_8 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008022 291.0
EH2_k127_7238503_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003566 260.0
EH2_k127_7263075_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 368.0
EH2_k127_7263075_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 307.0
EH2_k127_7263075_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000004143 167.0
EH2_k127_7263075_3 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000000000003371 161.0
EH2_k127_7263075_4 Putative zinc ribbon domain - - - 0.000000000000000008313 88.0
EH2_k127_7273280_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 607.0
EH2_k127_7273280_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000005615 239.0
EH2_k127_7273280_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000001017 185.0
EH2_k127_7273280_3 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000000000000000000000000000005579 149.0
EH2_k127_7309795_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 1.351e-201 636.0
EH2_k127_7309795_1 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 546.0
EH2_k127_7309795_10 - K14100 - - 0.000000009053 58.0
EH2_k127_7309795_2 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 377.0
EH2_k127_7309795_3 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 291.0
EH2_k127_7309795_4 4Fe-4S dicluster domain K11260,K14107 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004064 278.0
EH2_k127_7309795_5 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004928 258.0
EH2_k127_7309795_6 Predicted membrane protein (DUF2105) K14098 - - 0.000000000000000000000000000000000000000000000000000000001188 207.0
EH2_k127_7309795_7 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.00000000000000000000000000000000000000000000005774 169.0
EH2_k127_7309795_8 PFAM molydopterin dinucleotide-binding region K00201,K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.000000000000000000000000000000551 126.0
EH2_k127_7309795_9 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.0000000000000000001045 96.0
EH2_k127_7327406_0 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 503.0
EH2_k127_7327406_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 507.0
EH2_k127_7327406_10 SMART Tetratricopeptide domain protein - - - 0.0000003138 62.0
EH2_k127_7327406_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 391.0
EH2_k127_7327406_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 294.0
EH2_k127_7327406_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001771 266.0
EH2_k127_7327406_5 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005565 262.0
EH2_k127_7327406_6 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000003742 231.0
EH2_k127_7327406_7 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.00000000000000000000000000000000000000000000000000000000009441 211.0
EH2_k127_7327406_8 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000006794 184.0
EH2_k127_7327406_9 - - - - 0.0000000000002478 73.0
EH2_k127_7385928_0 Transport of potassium into the cell K03549 - - 1.989e-261 817.0
EH2_k127_7385928_1 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 560.0
EH2_k127_7385928_2 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 394.0
EH2_k127_7385928_3 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000217 277.0
EH2_k127_7385928_4 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000008593 204.0
EH2_k127_7385928_5 ATP synthase subunit C K02124 - - 0.00000000000000000000001842 101.0
EH2_k127_7385928_6 COG0464 ATPases of the AAA class K13525 - - 0.00001842 55.0
EH2_k127_7578211_0 NADH-Ubiquinone plastoquinone (complex I) K05568,K14115 - - 0.00000000000000000000000000000000000000000000000000001798 194.0
EH2_k127_7578211_1 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000000000000000000000000000000004388 188.0
EH2_k127_7578211_2 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000000000000000000000002469 143.0
EH2_k127_7578211_3 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000005302 106.0
EH2_k127_7578211_4 Domain of unknown function (DUF4040) - - - 0.00000000000000000000107 97.0
EH2_k127_7578211_5 Membrane bound hydrogenase - - - 0.00000000000000002054 85.0
EH2_k127_7597965_0 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 530.0
EH2_k127_7597965_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 343.0
EH2_k127_7597965_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 323.0
EH2_k127_7597965_3 PFAM Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004568 248.0
EH2_k127_7624548_0 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 346.0
EH2_k127_7624548_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000006448 200.0
EH2_k127_7624548_2 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000003532 157.0
EH2_k127_7624548_3 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000001945 142.0
EH2_k127_7624548_4 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000001171 51.0
EH2_k127_7740498_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 601.0
EH2_k127_9757_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 1.124e-236 747.0
EH2_k127_9757_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 9.02e-230 729.0
EH2_k127_9757_10 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 324.0
EH2_k127_9757_11 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002314 270.0
EH2_k127_9757_12 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001032 250.0
EH2_k127_9757_13 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000001688 213.0
EH2_k127_9757_14 PFAM PUA domain containing protein K07575 - - 0.00000000000000000000000000000000000000000000000000000006111 199.0
EH2_k127_9757_15 Pfam:DUF552 K09152 - - 0.000000000000000000000000000000000000000000000000000001188 194.0
EH2_k127_9757_16 ZPR1-related zinc finger protein K06874 - - 0.00000000000000000000000000000000000000000000001166 179.0
EH2_k127_9757_17 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000000000000001107 172.0
EH2_k127_9757_18 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000005891 166.0
EH2_k127_9757_19 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000009692 162.0
EH2_k127_9757_2 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 3.042e-218 692.0
EH2_k127_9757_20 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.0000000000000000000000000000000003237 132.0
EH2_k127_9757_21 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000004645 128.0
EH2_k127_9757_22 Zinc-ribbon containing domain - - - 0.0000000000000000000000000000009335 122.0
EH2_k127_9757_23 binds to the 23S rRNA K02922 - - 0.000000000000000000000000001677 111.0
EH2_k127_9757_24 Transglutaminase-like superfamily - - - 0.00000000000000000000000004574 123.0
EH2_k127_9757_25 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000001481 94.0
EH2_k127_9757_26 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000003514 76.0
EH2_k127_9757_27 - - - - 0.000004945 53.0
EH2_k127_9757_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.563e-216 681.0
EH2_k127_9757_4 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 5.883e-215 677.0
EH2_k127_9757_5 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 604.0
EH2_k127_9757_6 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 465.0
EH2_k127_9757_7 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 452.0
EH2_k127_9757_8 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 344.0
EH2_k127_9757_9 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 332.0