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Overview

ID MAG01078
Name EH2_bin.80
Sample SMP0029
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JAJRCY01
Species
Assembly information
Completeness (%) 60.31
Contamination (%) 1.37
GC content (%) 64.0
N50 (bp) 3,468
Genome size (bp) 1,030,038

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1167

Gene name Description KEGG GOs EC E-value Score Sequence
EH2_k127_1006820_0 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 330.0
EH2_k127_1006820_1 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000032 244.0
EH2_k127_1006820_2 Belongs to the UPF0212 family K09731 - - 0.0000000000000000000000000000000000000000000001397 173.0
EH2_k127_1006820_3 Family of unknown function (DUF5350) - - - 0.000000000000000000000003579 105.0
EH2_k127_100987_0 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 581.0
EH2_k127_100987_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 483.0
EH2_k127_100987_2 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009855 373.0
EH2_k127_100987_3 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 357.0
EH2_k127_100987_4 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009898 350.0
EH2_k127_100987_5 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 295.0
EH2_k127_100987_6 PFAM GHMP kinase K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007676 293.0
EH2_k127_100987_7 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000000006607 243.0
EH2_k127_100987_8 Protein of unknown function (DUF424) K09148 - - 0.0000000002902 61.0
EH2_k127_1027471_0 Lon protease (S16) C-terminal proteolytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002452 248.0
EH2_k127_1027471_1 Large-conductance mechanosensitive channel, MscL K03282 - - 0.0000000000000000000000000000001503 126.0
EH2_k127_1027471_2 EamA-like transporter family - - - 0.0000000003016 63.0
EH2_k127_1033186_0 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 494.0
EH2_k127_1033186_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 320.0
EH2_k127_1033186_2 Nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000000000000001337 176.0
EH2_k127_1033186_3 - - - - 0.0000000000000000000000000001717 117.0
EH2_k127_1049934_0 - - - - 0.0000000000000000000000000000000000000000000005899 173.0
EH2_k127_1049934_1 smart pdz dhr glgf - - - 0.00000000000000000000000000008385 129.0
EH2_k127_1079552_0 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 571.0
EH2_k127_1079552_1 MafB19-like deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 283.0
EH2_k127_1079552_2 Conserved repeat domain - - - 0.00000000000000000000000000000000000001723 164.0
EH2_k127_1079552_3 Protein of unknown function (DUF2769) - - - 0.000000000000000000000000000000000004179 139.0
EH2_k127_1079552_4 RNA polymerase II activating transcription factor binding - - - 0.0000000000000003993 93.0
EH2_k127_1079552_5 Metallo-beta-lactamase superfamily - - - 0.00001868 49.0
EH2_k127_1079552_6 extracellular matrix structural constituent - - - 0.00002134 51.0
EH2_k127_1082917_0 AAA-like domain K06915 - - 8.292e-228 717.0
EH2_k127_1082917_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.00000000000000000000000000000000000002145 146.0
EH2_k127_1094913_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 366.0
EH2_k127_1094913_1 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009935 332.0
EH2_k127_1094913_2 Protein phosphatase 2C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001113 252.0
EH2_k127_1094913_3 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000002849 213.0
EH2_k127_1094913_4 Serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000147 174.0
EH2_k127_1094913_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000004605 89.0
EH2_k127_1094913_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.0000000000004062 81.0
EH2_k127_1111458_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000512 448.0
EH2_k127_1111458_1 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 439.0
EH2_k127_1111458_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 383.0
EH2_k127_1111458_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000001949 128.0
EH2_k127_1111458_4 protein conserved in archaea - - - 0.000000000000000000000000001607 119.0
EH2_k127_1111458_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.000000000000009321 76.0
EH2_k127_1111458_6 - - - - 0.000000007211 60.0
EH2_k127_1122393_0 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000007043 158.0
EH2_k127_1122393_1 Domain of unknown function (DUF3821) - - - 0.00000000000881 75.0
EH2_k127_1122393_2 Helix-turn-helix domain - - - 0.00003749 48.0
EH2_k127_1139439_0 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000000000000000008397 205.0
EH2_k127_1140239_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 316.0
EH2_k127_1140239_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000174 233.0
EH2_k127_1140239_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000002825 231.0
EH2_k127_1140239_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000001901 208.0
EH2_k127_1140239_4 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.0000000000000000000000000000000000000001296 154.0
EH2_k127_1140239_5 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000000001186 101.0
EH2_k127_1140239_6 PFAM Ribosomal protein K02912 - - 0.00000000000000003004 89.0
EH2_k127_1140239_7 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000005603 65.0
EH2_k127_1145919_0 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 432.0
EH2_k127_1145919_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000004097 239.0
EH2_k127_1145919_2 - - - - 0.000000000000000000000000000000000000000002037 164.0
EH2_k127_1145919_3 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.000000000000000000000000000846 117.0
EH2_k127_1145919_4 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000001856 54.0
EH2_k127_1166949_0 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005347 276.0
EH2_k127_1166949_1 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000000000008092 198.0
EH2_k127_117288_0 PFAM ABC transporter K00400 - - 9.937e-214 670.0
EH2_k127_117288_1 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 559.0
EH2_k127_117288_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 487.0
EH2_k127_117288_3 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008491 242.0
EH2_k127_117288_4 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000000000003472 186.0
EH2_k127_1191381_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 349.0
EH2_k127_1191381_1 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000000000000000000000000000001683 174.0
EH2_k127_1207493_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 365.0
EH2_k127_1207493_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 354.0
EH2_k127_1207493_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000003211 169.0
EH2_k127_1207493_3 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000001086 88.0
EH2_k127_1290335_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 300.0
EH2_k127_1290335_1 PFAM LemA family K03744 - - 0.000000000000000000000000000000000000000000000005338 174.0
EH2_k127_1290335_2 PFAM PspC domain protein K03973 - - 0.000000000006092 72.0
EH2_k127_130793_0 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 519.0
EH2_k127_130793_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 379.0
EH2_k127_130793_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 349.0
EH2_k127_130793_3 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 319.0
EH2_k127_130793_4 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009343 303.0
EH2_k127_130793_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000000000000000000000000001958 130.0
EH2_k127_1345208_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1062.0
EH2_k127_1345208_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.294e-297 926.0
EH2_k127_1345208_2 - - - - 0.00000000000000000000000000000000000000003457 153.0
EH2_k127_1417273_0 sugar phosphatases of the HAD superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001222 270.0
EH2_k127_1417273_1 - - - - 0.000000000000000000000000000000000000000000000000002245 189.0
EH2_k127_1417273_2 Domain of unknown function (DUF4405) - - - 0.0000000634 59.0
EH2_k127_1452940_0 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 590.0
EH2_k127_1452940_1 - - - - 0.00000000000000000000000004785 111.0
EH2_k127_1452940_2 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000005321 68.0
EH2_k127_1485214_0 amino acid activation for nonribosomal peptide biosynthetic process K06045 - 4.2.1.129,5.4.99.17 0.000000000000000113 91.0
EH2_k127_1485214_1 - - - - 0.000000000004053 68.0
EH2_k127_1534856_0 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 439.0
EH2_k127_1534856_1 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 336.0
EH2_k127_1666906_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 442.0
EH2_k127_1666906_1 Ras family K06945 - - 0.0000000000000000000000000000000000000000000000000146 184.0
EH2_k127_1666906_3 - - - - 0.00000000000000001974 86.0
EH2_k127_1666906_4 - - - - 0.000000002665 61.0
EH2_k127_1699405_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.952e-319 984.0
EH2_k127_1699405_1 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 351.0
EH2_k127_1744956_0 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 440.0
EH2_k127_1744956_1 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005381 279.0
EH2_k127_1744956_2 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000000000000000000000000000001771 183.0
EH2_k127_1744956_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000008374 82.0
EH2_k127_1802683_0 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 453.0
EH2_k127_1802683_1 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 288.0
EH2_k127_1802683_2 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004331 262.0
EH2_k127_1802683_3 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000005925 215.0
EH2_k127_1802683_4 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000004474 158.0
EH2_k127_1802683_5 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000000001968 158.0
EH2_k127_1819123_0 TIGRFAM N-acetyl sugar amidotransferase - - - 7.689e-227 706.0
EH2_k127_1819123_1 PFAM acylneuraminate cytidylyltransferase K18431 - 2.7.7.82 0.000000000000000000000000000000000000000000000000000000000000000000000008214 250.0
EH2_k127_1819123_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000007784 151.0
EH2_k127_1820988_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 290.0
EH2_k127_1820988_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004105 280.0
EH2_k127_1820988_2 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000175 168.0
EH2_k127_1820988_3 Zinc-ribbon containing domain - - - 0.000000000000000000000000000001669 122.0
EH2_k127_1820988_4 Peptidase M50 - - - 0.000000000000000000000000000006377 122.0
EH2_k127_1820988_5 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.00000000000002551 72.0
EH2_k127_1826575_0 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009416 325.0
EH2_k127_1826575_1 PFAM PKD domain containing protein - - - 0.000000000356 65.0
EH2_k127_1835852_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 1.599e-231 728.0
EH2_k127_1835852_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000006099 244.0
EH2_k127_1835852_2 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000003079 122.0
EH2_k127_1835852_3 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000001287 77.0
EH2_k127_1840699_0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000000000000000000000000000000005876 232.0
EH2_k127_1840699_1 Flavodoxin - GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000001079 216.0
EH2_k127_1840699_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000002787 189.0
EH2_k127_1856541_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 331.0
EH2_k127_1856541_1 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 285.0
EH2_k127_1856541_2 resolvase K14060 - - 0.0000000000000000000000000000000000000000002037 166.0
EH2_k127_1865362_0 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 296.0
EH2_k127_1865362_1 PFAM Glutamine amidotransferase class-I - - - 0.00000000000000000000000000000000000000000000000000000001379 203.0
EH2_k127_1865362_2 methanogenesis marker protein 11 - - - 0.00000000000000000000007083 101.0
EH2_k127_1914922_0 Cysteine-rich small domain K08260 - 3.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 376.0
EH2_k127_1914922_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000006537 237.0
EH2_k127_1914922_2 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000003544 106.0
EH2_k127_2014926_0 helicase activity - - - 1.046e-206 653.0
EH2_k127_2014926_1 - - - - 0.00000000000000000000000000000000000000000118 161.0
EH2_k127_202779_0 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008906 449.0
EH2_k127_202779_1 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 372.0
EH2_k127_202779_2 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000001847 85.0
EH2_k127_202779_3 PFAM SufBD protein K07033 - - 0.0000000002799 64.0
EH2_k127_2032315_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 449.0
EH2_k127_2032315_1 Anaerobic ribonucleoside-triphosphate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000004144 216.0
EH2_k127_2032315_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000001611 209.0
EH2_k127_2032315_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000001076 102.0
EH2_k127_2032315_4 Domain of unknown function DUF11 - - - 0.00000006144 64.0
EH2_k127_2057507_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 580.0
EH2_k127_2057507_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 532.0
EH2_k127_2057507_2 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004803 259.0
EH2_k127_2057507_3 NMT1-like family K02051 - - 0.0000000000000000000002508 100.0
EH2_k127_2057507_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.000000261 53.0
EH2_k127_207368_0 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006671 458.0
EH2_k127_207368_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 338.0
EH2_k127_207368_2 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 304.0
EH2_k127_207368_3 PDGLE domain K02009 - - 0.000000000000000000000000000007999 121.0
EH2_k127_207368_4 TIGRFAM geranylgeranyl reductase - - - 0.000000001543 61.0
EH2_k127_2086392_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 551.0
EH2_k127_2086392_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 526.0
EH2_k127_2086392_2 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008326 296.0
EH2_k127_2086392_3 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000104 259.0
EH2_k127_2086392_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000004175 133.0
EH2_k127_2096587_0 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 1.58e-214 684.0
EH2_k127_2096587_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 566.0
EH2_k127_2096587_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 462.0
EH2_k127_2096587_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 379.0
EH2_k127_2096587_4 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001461 261.0
EH2_k127_2096587_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000004231 157.0
EH2_k127_2100801_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 592.0
EH2_k127_2100801_1 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 424.0
EH2_k127_2100801_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 332.0
EH2_k127_2100801_3 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 330.0
EH2_k127_2100801_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000003939 258.0
EH2_k127_2113952_0 FAD dependent oxidoreductase - - - 0.000000000000002127 89.0
EH2_k127_2125273_0 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 533.0
EH2_k127_2125273_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 313.0
EH2_k127_2125273_2 PBS lyase - - - 0.000000000000004429 81.0
EH2_k127_2125273_3 PFAM PP-loop domain protein - - - 0.0000002278 55.0
EH2_k127_2186247_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002518 278.0
EH2_k127_2186247_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000003294 225.0
EH2_k127_2186247_2 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000004374 125.0
EH2_k127_2186247_3 helicase activity K06915 - - 0.000000000000000000000005611 111.0
EH2_k127_22223_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 409.0
EH2_k127_22223_1 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000008764 182.0
EH2_k127_22223_2 PBS lyase K22221 - - 0.0000000000000000000000000000000000000000000006978 181.0
EH2_k127_22223_3 - - - - 0.0000000000000000000000000000000000001269 148.0
EH2_k127_2235970_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 411.0
EH2_k127_2235970_1 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000005478 61.0
EH2_k127_2235970_2 - - - - 0.00000001018 59.0
EH2_k127_2235970_3 - - - - 0.0000003069 60.0
EH2_k127_2239895_0 ZIP Zinc transporter K07238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 325.0
EH2_k127_2239895_1 COG2406 Protein distantly related to bacterial ferritins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 314.0
EH2_k127_2240421_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 306.0
EH2_k127_2240421_1 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000001013 104.0
EH2_k127_2267254_0 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 497.0
EH2_k127_2267254_1 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 312.0
EH2_k127_2267254_2 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000006682 242.0
EH2_k127_2355268_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 370.0
EH2_k127_2355268_1 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000005454 222.0
EH2_k127_2355268_2 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000121 207.0
EH2_k127_2359616_0 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.0000000000000000000000000000001923 128.0
EH2_k127_2359616_1 - - - - 0.0000000000000000000000000003966 131.0
EH2_k127_2359616_2 - - - - 0.000000002574 58.0
EH2_k127_2376569_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 495.0
EH2_k127_2376569_1 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 454.0
EH2_k127_2397124_0 PFAM peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 631.0
EH2_k127_2397124_1 RNA methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 370.0
EH2_k127_2397124_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000001798 209.0
EH2_k127_2397124_3 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000001801 120.0
EH2_k127_2413583_0 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000446 257.0
EH2_k127_2413583_1 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000007316 197.0
EH2_k127_2421462_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 450.0
EH2_k127_2421462_1 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000198 204.0
EH2_k127_2421462_2 Polysaccharide biosynthesis protein - - - 0.000002231 52.0
EH2_k127_2422828_0 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 378.0
EH2_k127_2422828_1 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 365.0
EH2_k127_2422828_2 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009999 327.0
EH2_k127_2422828_3 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
EH2_k127_2422828_4 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000002771 145.0
EH2_k127_2426112_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1.035e-298 925.0
EH2_k127_2426112_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 517.0
EH2_k127_2426112_2 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000008912 261.0
EH2_k127_2428609_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 361.0
EH2_k127_2428609_1 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000881 243.0
EH2_k127_2428609_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000008023 229.0
EH2_k127_2428609_3 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000002995 213.0
EH2_k127_2428609_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000007048 202.0
EH2_k127_2428609_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000001051 192.0
EH2_k127_2428609_6 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000002882 170.0
EH2_k127_2428609_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000006492 53.0
EH2_k127_2436409_0 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 448.0
EH2_k127_2436409_1 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 356.0
EH2_k127_2436409_2 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 331.0
EH2_k127_2436409_3 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000003569 144.0
EH2_k127_2444923_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.865e-258 803.0
EH2_k127_2444923_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 592.0
EH2_k127_2444923_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 498.0
EH2_k127_2444923_3 PFAM thioesterase superfamily - - - 0.00000000000000000000000000002886 118.0
EH2_k127_2448652_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006672 519.0
EH2_k127_2448652_1 MviN-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004754 271.0
EH2_k127_2448652_2 Putative small multi-drug export protein - - - 0.000000000000000000000000000003389 123.0
EH2_k127_2448652_3 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.000000001824 66.0
EH2_k127_2457729_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 7.776e-236 735.0
EH2_k127_2457729_1 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000005076 199.0
EH2_k127_2457729_2 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000001226 184.0
EH2_k127_2457729_3 - - - - 0.000000000000003498 79.0
EH2_k127_2568485_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 357.0
EH2_k127_2568485_1 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001153 244.0
EH2_k127_2568485_2 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000001497 191.0
EH2_k127_2595200_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 597.0
EH2_k127_2595200_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000002021 246.0
EH2_k127_260003_0 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 333.0
EH2_k127_260003_1 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008719 283.0
EH2_k127_260003_2 ribosomal protein S15 K02956 - - 0.0000000000000000000000000000000000000000000000000000000000005481 216.0
EH2_k127_2617753_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 3.003e-197 619.0
EH2_k127_2617753_1 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000001599 100.0
EH2_k127_2617753_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0002377 46.0
EH2_k127_2644895_0 - K03561,K12287 - - 0.00000000000000000000000000000000000000000000000112 195.0
EH2_k127_2651242_0 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 417.0
EH2_k127_2651242_1 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 306.0
EH2_k127_2651242_2 - - - - 0.00000000000000000000000000000000000000000000000000000000001161 219.0
EH2_k127_2651242_3 PFAM Radical SAM domain protein K02585 - - 0.0000000000000009021 76.0
EH2_k127_2653993_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 2.37e-244 759.0
EH2_k127_2653993_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002309 280.0
EH2_k127_2653993_2 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000001976 169.0
EH2_k127_2653993_3 adenyl ribonucleotide binding - - - 0.00000000000000000000000000000000000004158 151.0
EH2_k127_265412_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 588.0
EH2_k127_265412_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 310.0
EH2_k127_265412_2 Peptidyl-prolyl cis-trans isomerase K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000001139 235.0
EH2_k127_265412_3 Molybdopterin converting factor K03635 - 2.8.1.12 0.0000000000000000000000000000000000000002355 153.0
EH2_k127_265412_4 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000001145 136.0
EH2_k127_265412_5 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000000000001275 94.0
EH2_k127_265412_6 - - - - 0.0000000000000002735 87.0
EH2_k127_2668959_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 441.0
EH2_k127_2668959_1 Uncharacterised conserved protein UCP033563 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 339.0
EH2_k127_2668959_2 - - - - 0.00000000000000000000003254 103.0
EH2_k127_2668959_3 - - - - 0.000000000000000004445 91.0
EH2_k127_2673827_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 376.0
EH2_k127_2673827_1 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 314.0
EH2_k127_2686009_0 Lon protease (S16) C-terminal proteolytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000009203 232.0
EH2_k127_2686009_1 EamA-like transporter family - - - 0.0000000000000000000000000000000006599 145.0
EH2_k127_2686009_2 amino acid K03294 - - 0.00001183 49.0
EH2_k127_2705831_0 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 442.0
EH2_k127_2705831_1 - - - - 0.000000000000004507 82.0
EH2_k127_2755629_0 PFAM Radical SAM domain protein K06937 - - 2.004e-245 765.0
EH2_k127_2755629_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 538.0
EH2_k127_2755629_2 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 411.0
EH2_k127_2755629_3 Uncharacterised protein family UPF0058 - - - 0.000000000000000000000000000000000000003034 151.0
EH2_k127_2755629_4 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.0000000000000000009455 93.0
EH2_k127_2773330_0 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008821 310.0
EH2_k127_2773330_1 Uncharacterised protein family UPF0058 - - - 0.00000000000000000000000000000000000001896 153.0
EH2_k127_2773330_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000003797 117.0
EH2_k127_2778541_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 1.014e-263 829.0
EH2_k127_2778541_1 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 620.0
EH2_k127_2778541_2 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 329.0
EH2_k127_2778541_3 Belongs to the UPF0280 family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001118 293.0
EH2_k127_2778541_4 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005478 256.0
EH2_k127_2778541_5 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000001573 248.0
EH2_k127_2778541_6 - - - - 0.00000000000000000000000000005574 121.0
EH2_k127_2778541_7 - - - - 0.000000000000000000000000001216 124.0
EH2_k127_2778541_8 - - - - 0.00000000001208 73.0
EH2_k127_2801975_0 DEAD DEAH box helicase domain protein K10896 - - 1.339e-260 818.0
EH2_k127_2824018_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 529.0
EH2_k127_2824018_1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 319.0
EH2_k127_2824018_2 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 287.0
EH2_k127_2824018_3 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000001271 211.0
EH2_k127_2824018_4 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000009226 166.0
EH2_k127_2824018_5 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000000000000000173 153.0
EH2_k127_2824018_6 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000002826 122.0
EH2_k127_2882496_0 PFAM PKD domain containing protein - - - 0.00000000000000000007036 105.0
EH2_k127_2885710_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.014e-208 667.0
EH2_k127_2885710_1 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 298.0
EH2_k127_2885710_2 - - - - 0.000000000000000000000000000000000000000000000002644 177.0
EH2_k127_2885710_3 - - - - 0.00000000000000000003047 91.0
EH2_k127_2885710_5 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0003798 44.0
EH2_k127_2922264_0 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 449.0
EH2_k127_2922264_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 351.0
EH2_k127_2922264_2 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 291.0
EH2_k127_2932774_0 Male sterility protein K00067 - 1.1.1.133 0.00000000000000000000000007406 111.0
EH2_k127_2932774_1 - - - - 0.0000000000005757 82.0
EH2_k127_2990095_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 315.0
EH2_k127_2990095_1 PFAM HhH-GPD family protein K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001892 285.0
EH2_k127_2990095_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006291 246.0
EH2_k127_2990095_3 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000001719 209.0
EH2_k127_2990095_4 GyrI-like small molecule binding domain - - - 0.000000000000000000000000000000000000000000000004323 181.0
EH2_k127_2990095_5 - - - - 0.0000000000000000009076 93.0
EH2_k127_2990095_6 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.000000000000002162 77.0
EH2_k127_2991975_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.905e-267 834.0
EH2_k127_2991975_1 acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 547.0
EH2_k127_3033240_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 581.0
EH2_k127_3033240_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 503.0
EH2_k127_3033240_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 444.0
EH2_k127_3033240_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 426.0
EH2_k127_3033240_4 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 342.0
EH2_k127_3033240_5 Oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000004508 259.0
EH2_k127_3038261_0 protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000001972 229.0
EH2_k127_3038261_1 PFAM peptidase zinc-dependent K06974 - - 0.00000000000000000000000000000000000000000000000001912 185.0
EH2_k127_3038261_2 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000003318 151.0
EH2_k127_3042571_0 in RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 494.0
EH2_k127_3042571_1 Domain of unknown function (DUF814) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 333.0
EH2_k127_3042571_2 RNase L inhibitor, RLI - - - 0.000000000000000000004982 96.0
EH2_k127_3099476_0 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 389.0
EH2_k127_3099476_1 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000645 174.0
EH2_k127_3099476_2 B-block binding subunit of TFIIIC - - - 0.0000000000000000000000000000000000000000000959 162.0
EH2_k127_3099476_3 PFAM Like-Sm ribonucleoprotein, core - - - 0.0000000000000000000000000000002338 125.0
EH2_k127_3099476_4 - - - - 0.00000000000000000003491 98.0
EH2_k127_3099476_5 - - - - 0.00000000000000002521 89.0
EH2_k127_3183376_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 2.012e-311 963.0
EH2_k127_3183376_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000009311 59.0
EH2_k127_3186562_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 8.182e-319 991.0
EH2_k127_3186562_1 PFAM PilT protein domain protein K06865 - - 8.651e-267 834.0
EH2_k127_3189253_0 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 361.0
EH2_k127_3189253_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 348.0
EH2_k127_3189253_2 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000001598 237.0
EH2_k127_3189253_3 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.0000000000000000000000000000000000000000000000000000000000000001775 226.0
EH2_k127_3189253_4 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000006677 167.0
EH2_k127_3203543_0 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006037 404.0
EH2_k127_3203543_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 310.0
EH2_k127_3203543_2 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000006809 170.0
EH2_k127_3203543_3 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000000000000001338 164.0
EH2_k127_3203543_4 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000000000000005796 131.0
EH2_k127_3214669_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.68e-224 704.0
EH2_k127_3214669_1 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008894 323.0
EH2_k127_3214669_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000401 230.0
EH2_k127_3214669_3 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000001287 220.0
EH2_k127_3239713_0 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001251 279.0
EH2_k127_3239713_1 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000001033 231.0
EH2_k127_3239713_2 transferase hexapeptide repeat K00633 - 2.3.1.18 0.0000000000000000000000000000001745 130.0
EH2_k127_3239713_3 cyclase family - - - 0.00000000000000000005756 98.0
EH2_k127_3252068_0 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 3.01e-218 689.0
EH2_k127_3252068_1 - - - - 0.0000000000000000001562 96.0
EH2_k127_3252451_0 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000833 249.0
EH2_k127_3252451_1 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004135 242.0
EH2_k127_3252451_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000002641 173.0
EH2_k127_3252451_3 SMART Excinuclease ABC, C subunit - - - 0.000000000000000000000000000000000000000000003292 172.0
EH2_k127_3252451_4 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000001475 142.0
EH2_k127_3303047_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 323.0
EH2_k127_3303047_1 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000000451 144.0
EH2_k127_3303047_2 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.000000000000000000001003 99.0
EH2_k127_3303047_4 PFAM response regulator receiver K11443 - - 0.0000000000000001152 85.0
EH2_k127_3305118_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 356.0
EH2_k127_3305118_1 - - - - 0.00000000000000000003745 102.0
EH2_k127_3310727_0 Iron-sulfur cluster-binding domain K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 534.0
EH2_k127_3310727_1 Sulfatase K01130 - 3.1.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 509.0
EH2_k127_3310727_2 sulphate transporter K03321 - - 0.0000000000000000000001058 102.0
EH2_k127_3319193_0 Belongs to the glutamate synthase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 532.0
EH2_k127_3319193_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000001449 193.0
EH2_k127_3319193_2 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000001048 198.0
EH2_k127_3319193_3 - - - - 0.0000000000000000000000002218 110.0
EH2_k127_3319193_4 Protein of unknown function (DUF1622) - - - 0.000000000000000000081 96.0
EH2_k127_3336392_0 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 359.0
EH2_k127_3336392_1 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000001469 237.0
EH2_k127_3379469_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003893 253.0
EH2_k127_3379469_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000002444 215.0
EH2_k127_3379469_2 domain protein - - - 0.000000000000000000000000002071 114.0
EH2_k127_3379469_3 PFAM 4Fe-4S - - - 0.0000001373 56.0
EH2_k127_3379469_4 TfoX N-terminal domain - - - 0.000006187 53.0
EH2_k127_3395664_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 7.627e-259 809.0
EH2_k127_3395664_1 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000733 238.0
EH2_k127_3407277_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 8.897e-197 633.0
EH2_k127_3407277_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007844 418.0
EH2_k127_3436314_0 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 554.0
EH2_k127_3436314_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 426.0
EH2_k127_3436314_2 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 308.0
EH2_k127_3436314_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000003692 97.0
EH2_k127_3436314_4 - - - - 0.00000000000000001276 87.0
EH2_k127_3437532_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.684e-206 650.0
EH2_k127_3437532_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 343.0
EH2_k127_3437532_2 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000002899 263.0
EH2_k127_3437532_3 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000006833 183.0
EH2_k127_3437532_4 - - - - 0.0000000000000001057 85.0
EH2_k127_3448225_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 540.0
EH2_k127_3448225_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 404.0
EH2_k127_3448225_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000001049 98.0
EH2_k127_3448225_3 - K06868 - 2.5.1.73 0.00000000881 60.0
EH2_k127_3448382_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 379.0
EH2_k127_3448382_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 327.0
EH2_k127_3448382_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003258 256.0
EH2_k127_3448382_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000009566 121.0
EH2_k127_3448382_4 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.00000000003237 64.0
EH2_k127_3496032_0 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007117 272.0
EH2_k127_3496032_1 PFAM Isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001169 241.0
EH2_k127_3520546_0 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 488.0
EH2_k127_3520546_1 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000008557 219.0
EH2_k127_3520546_2 Belongs to the UPF0305 family - - - 0.0000000000000000000000000000000000000008403 151.0
EH2_k127_3531162_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 4.4e-323 1010.0
EH2_k127_3531162_1 protein conserved in archaea - - - 0.000000000000000000000000000000000000000000000000000000000000000166 233.0
EH2_k127_3531162_2 - - - - 0.00005114 50.0
EH2_k127_3533422_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 449.0
EH2_k127_3533422_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 401.0
EH2_k127_3533422_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003162 277.0
EH2_k127_3533422_3 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006716 262.0
EH2_k127_3533422_4 metallopeptidase activity - - - 0.0000000000000000000000000000002223 136.0
EH2_k127_3565062_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 1.553e-200 632.0
EH2_k127_3565062_1 4Fe-4S dicluster domain K11260,K14107 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004675 255.0
EH2_k127_3565062_2 PFAM molydopterin dinucleotide-binding region K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.00000000000000000000000000000000002959 138.0
EH2_k127_3569851_0 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 312.0
EH2_k127_3569851_1 protein involved in methicillin resistance - - - 0.000000000000000000000000000000006486 138.0
EH2_k127_3569851_2 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0000000008591 62.0
EH2_k127_3630453_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 572.0
EH2_k127_3760899_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 419.0
EH2_k127_3760899_1 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000274 278.0
EH2_k127_3760899_2 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005322 266.0
EH2_k127_3771911_0 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000008761 214.0
EH2_k127_3771911_1 Small multi-drug export protein - - - 0.000000000000000000000000000000000004841 146.0
EH2_k127_3818304_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 349.0
EH2_k127_3818304_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000524 219.0
EH2_k127_3818304_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000001386 84.0
EH2_k127_3834579_0 Hydrogenase maturation protease K08315 - 3.4.23.51 0.00000000000000000000000000000000001487 139.0
EH2_k127_3834579_1 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000001404 134.0
EH2_k127_3834579_2 Transcriptional regulator - - - 0.0001865 51.0
EH2_k127_3834583_0 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 567.0
EH2_k127_3834583_1 PFAM TrkA-N domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 332.0
EH2_k127_3834583_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000817 51.0
EH2_k127_3839792_0 TIGRFAM cell division ATPase MinD K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 344.0
EH2_k127_3839792_1 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003929 275.0
EH2_k127_3839792_2 - - - - 0.0000000001696 69.0
EH2_k127_3839792_3 - - - - 0.0001459 51.0
EH2_k127_3854752_0 PFAM ferredoxin-dependent glutamate synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 558.0
EH2_k127_3854752_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 490.0
EH2_k127_3854752_2 - - - - 0.0000000000000000000000000000000000000000000000000000000002455 211.0
EH2_k127_3876120_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001486 273.0
EH2_k127_3876120_1 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000000000000000000000007236 132.0
EH2_k127_3876120_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000242 109.0
EH2_k127_3879689_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 331.0
EH2_k127_3879689_1 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001261 252.0
EH2_k127_3879689_2 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000000000001407 239.0
EH2_k127_3879689_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000001738 241.0
EH2_k127_3879689_4 binds to the 23S rRNA K02885 - - 0.000000000000000000000000000000000000000000000000000000000001688 213.0
EH2_k127_3879689_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000001424 192.0
EH2_k127_3879689_6 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000004526 169.0
EH2_k127_3879689_7 PFAM Ribosomal protein K02912 - - 0.00000000000000000000000000001422 123.0
EH2_k127_3887839_0 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 487.0
EH2_k127_3887839_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000003579 256.0
EH2_k127_3887839_2 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000005323 216.0
EH2_k127_3887839_3 Belongs to the UPF0305 family - - - 0.00000000000000000000000000000000000000000000000009745 185.0
EH2_k127_3887839_4 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000003194 123.0
EH2_k127_3922291_0 AMP-binding enzyme - - - 1.177e-236 737.0
EH2_k127_3922291_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000003471 181.0
EH2_k127_3922291_2 UV-endonuclease UvdE K13281 - - 0.00000000001338 68.0
EH2_k127_3937630_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 476.0
EH2_k127_3937630_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 357.0
EH2_k127_3937630_2 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 349.0
EH2_k127_3937630_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004349 331.0
EH2_k127_3937630_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000000000000000000000003601 222.0
EH2_k127_3937630_5 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000144 193.0
EH2_k127_3937630_6 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000003812 115.0
EH2_k127_3937630_7 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000002581 93.0
EH2_k127_3937630_8 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000007025 90.0
EH2_k127_3937630_9 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.000000000000000006397 93.0
EH2_k127_3980902_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 8.41e-247 777.0
EH2_k127_3980902_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 393.0
EH2_k127_3980902_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000000000000000004482 161.0
EH2_k127_3980902_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000000003262 150.0
EH2_k127_3980902_4 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000006384 83.0
EH2_k127_3980902_5 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000004927 74.0
EH2_k127_4016438_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007212 518.0
EH2_k127_4016438_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 484.0
EH2_k127_4016438_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008981 443.0
EH2_k127_4016438_3 serine threonine protein kinase K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 327.0
EH2_k127_4016438_4 KH domain protein K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000034 228.0
EH2_k127_4018297_0 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 371.0
EH2_k127_4018297_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
EH2_k127_4018297_2 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000001382 190.0
EH2_k127_4018297_3 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.00000000000000000000000000000004322 129.0
EH2_k127_4022640_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 568.0
EH2_k127_4022640_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000000000000000000003452 201.0
EH2_k127_4045893_0 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000001346 121.0
EH2_k127_4045893_1 - - - - 0.00000000000000000000000000001233 129.0
EH2_k127_4045893_2 - - - - 0.0000000000004556 71.0
EH2_k127_4109560_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 457.0
EH2_k127_4109560_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009368 278.0
EH2_k127_4109560_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000008152 201.0
EH2_k127_4109560_3 - K06193 - - 0.0000000006149 70.0
EH2_k127_4143681_0 PFAM TM2 domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 308.0
EH2_k127_4143681_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000002103 214.0
EH2_k127_4143681_2 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000000000000000000006368 196.0
EH2_k127_4191706_0 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000003132 198.0
EH2_k127_4191706_1 COG0518 GMP synthase - Glutamine amidotransferase domain K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000009471 197.0
EH2_k127_4219846_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 2.422e-238 745.0
EH2_k127_4219846_1 DEAD DEAH box helicase domain protein K10896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001552 272.0
EH2_k127_4229345_0 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 319.0
EH2_k127_4229345_1 PFAM Methyl-coenzyme M reductase, protein D K03422 - - 0.000000000000000000000000000000000000000000000000007533 184.0
EH2_k127_4229345_2 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 0.0000000000000000000000000000001682 123.0
EH2_k127_4229345_3 PFAM Methyl-coenzyme M reductase gamma subunit K00402 - 2.8.4.1 0.000000000000000000000001458 104.0
EH2_k127_4240256_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 1.057e-194 616.0
EH2_k127_4240256_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 344.0
EH2_k127_4240256_2 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006257 275.0
EH2_k127_4240256_3 - - - - 0.00000000000000000000000000000000000003182 147.0
EH2_k127_4240256_4 - - - - 0.000000000000000005563 83.0
EH2_k127_427144_0 PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000002506 208.0
EH2_k127_427144_1 PFAM Yip1 domain - - - 0.000000000001145 74.0
EH2_k127_4275338_0 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000001891 121.0
EH2_k127_4275338_1 Acetyltransferase GNAT family - - - 0.0000000000000000000182 97.0
EH2_k127_4291941_0 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 4.355e-194 617.0
EH2_k127_4291941_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001656 241.0
EH2_k127_4329394_0 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000005185 177.0
EH2_k127_4329394_1 glycosyl transferase family 2 - - - 0.000000000000000000000000002049 119.0
EH2_k127_4329394_2 dTDP-4-dehydrorhamnose reductase K00067 - 1.1.1.133 0.0000000000000001264 91.0
EH2_k127_4379591_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 445.0
EH2_k127_4379591_1 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000007278 225.0
EH2_k127_4379591_2 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000439 97.0
EH2_k127_4415944_0 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 347.0
EH2_k127_4415944_1 integral membrane protein - - - 0.000000000000000000000000000000000000000000006714 170.0
EH2_k127_4415944_2 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.000000000000000000000000000001722 123.0
EH2_k127_4415944_3 RDD family - - - 0.00000000000000003367 91.0
EH2_k127_4415944_4 PBS lyase HEAT-like repeat - - - 0.000000000000006101 86.0
EH2_k127_4419020_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 5.376e-317 990.0
EH2_k127_4419020_1 - - - - 0.000000000000000000000000001434 114.0
EH2_k127_4419020_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000149 79.0
EH2_k127_4428587_0 KH, type 1, domain K07041 - - 0.0 1088.0
EH2_k127_4428587_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 317.0
EH2_k127_4428587_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 307.0
EH2_k127_4456538_0 serine-type endopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 355.0
EH2_k127_4456538_1 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.00000000000000000000000000000000000000007583 156.0
EH2_k127_4456538_2 Phage-related minor tail protein - - - 0.00000000001762 75.0
EH2_k127_4477912_0 DEAD DEAH box helicase domain protein K03725 - - 1.786e-262 832.0
EH2_k127_4477912_1 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 399.0
EH2_k127_4477912_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008152 265.0
EH2_k127_4477912_3 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000381 243.0
EH2_k127_4477912_4 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000001856 235.0
EH2_k127_4477912_5 Polymer-forming cytoskeletal - - - 0.00000001832 56.0
EH2_k127_4499245_0 Protein-export membrane protein SecD K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 582.0
EH2_k127_4499245_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 283.0
EH2_k127_4499245_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002776 229.0
EH2_k127_4499245_3 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000001975 152.0
EH2_k127_4499245_4 PFAM Thioredoxin K03671 - - 0.0000000000000000000000000000000000009979 141.0
EH2_k127_4518607_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1209.0
EH2_k127_4518607_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 387.0
EH2_k127_4518607_2 negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment - - - 0.000000000000000000000000000000000000000000000000000000000002536 221.0
EH2_k127_4518607_3 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.00000000000000000000002182 102.0
EH2_k127_4518666_0 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 299.0
EH2_k127_4518666_1 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000005919 235.0
EH2_k127_4518666_2 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000001059 70.0
EH2_k127_4532059_0 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 391.0
EH2_k127_4532059_1 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 320.0
EH2_k127_4532059_2 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004511 283.0
EH2_k127_4532059_3 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
EH2_k127_4532059_4 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000000000000001902 227.0
EH2_k127_4532059_5 Protein of unknown function (DUF3467) - - - 0.000000000000000000000000000000000298 145.0
EH2_k127_4532059_7 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000001128 61.0
EH2_k127_4544619_0 B-block binding subunit of TFIIIC - - - 0.0000000000000000000000000000000000000000000003247 169.0
EH2_k127_4544619_1 PFAM Like-Sm ribonucleoprotein, core - - - 0.000000000000000000000000000000001079 132.0
EH2_k127_4544619_2 - - - - 0.0000000000000000002845 98.0
EH2_k127_4544619_3 - - - - 0.000000000000000001649 93.0
EH2_k127_4544619_4 NADPH-dependent FMN reductase - - - 0.0000000000005498 69.0
EH2_k127_4544619_5 periplasmic binding protein K02016 - - 0.0000000000113 68.0
EH2_k127_4557656_0 CHASE4 domain - - - 0.000000000000000000000000000000000000000000000000000006135 211.0
EH2_k127_4557656_1 PAS domain - - - 0.00000000000000000002262 106.0
EH2_k127_4566983_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 390.0
EH2_k127_4566983_1 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 308.0
EH2_k127_4566983_2 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000003073 253.0
EH2_k127_4566983_3 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000000000002482 114.0
EH2_k127_4660705_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 604.0
EH2_k127_4660705_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 542.0
EH2_k127_4660705_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 396.0
EH2_k127_4660705_3 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001968 254.0
EH2_k127_4660705_4 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000006524 227.0
EH2_k127_4660705_5 PRC-barrel domain - - - 0.000000000006631 68.0
EH2_k127_4663731_0 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000001443 184.0
EH2_k127_4663731_1 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.000000000000000000000000000000005989 128.0
EH2_k127_4663731_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000005531 126.0
EH2_k127_4663731_3 Binds to the 23S rRNA K02896 - - 0.00000000000000000000000000006975 117.0
EH2_k127_4663731_4 Putative zinc ribbon domain - - - 0.00000000000000005034 84.0
EH2_k127_4676366_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009659 414.0
EH2_k127_4676366_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 391.0
EH2_k127_4676366_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000672 94.0
EH2_k127_4694769_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.508e-227 714.0
EH2_k127_4694769_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007685 252.0
EH2_k127_4718391_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000001213 102.0
EH2_k127_4718391_1 PFAM PEGA domain - - - 0.00004625 55.0
EH2_k127_4762134_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000000000000000007644 213.0
EH2_k127_4762134_1 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000221 205.0
EH2_k127_4793471_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 8.289e-266 829.0
EH2_k127_4793471_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.0000000000000000000000000000000000000000000001453 174.0
EH2_k127_4801_0 PFAM Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 396.0
EH2_k127_4801_1 domain, Protein K02117,K08678,K15125,K21636 - 1.1.98.6,3.6.3.14,3.6.3.15,4.1.1.35 0.0005476 51.0
EH2_k127_484528_0 Ferrous iron transport B domain protein K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 535.0
EH2_k127_484528_1 PFAM conserved K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 383.0
EH2_k127_484528_2 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 336.0
EH2_k127_484528_3 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005421 312.0
EH2_k127_484528_4 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000001028 177.0
EH2_k127_484528_5 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000000000000000000003563 140.0
EH2_k127_4898094_0 Heat shock 70 kDa protein K04043 - - 5.642e-296 919.0
EH2_k127_4898094_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 514.0
EH2_k127_4898094_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000008732 110.0
EH2_k127_4916709_0 Alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006971 352.0
EH2_k127_4916709_1 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009428 267.0
EH2_k127_4916709_2 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002111 238.0
EH2_k127_4916709_3 - - - - 0.000003366 57.0
EH2_k127_492280_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 546.0
EH2_k127_492280_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 381.0
EH2_k127_492280_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001262 274.0
EH2_k127_4934119_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1482.0
EH2_k127_4934119_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 424.0
EH2_k127_4934119_2 TIGRFAM TIGR00725 family protein K06966 - 3.2.2.10 0.000000000000000000000000000000004547 138.0
EH2_k127_4946317_0 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007931 397.0
EH2_k127_4946317_1 - - - - 0.0000000000000000000000000000000000000000001281 165.0
EH2_k127_4946317_2 - - - - 0.0000000000000000002524 93.0
EH2_k127_4946317_3 - - - - 0.00005762 51.0
EH2_k127_495490_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.289e-308 956.0
EH2_k127_495490_1 - - - - 0.00003538 47.0
EH2_k127_4962402_0 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000002993 236.0
EH2_k127_4962402_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000003529 207.0
EH2_k127_4962402_2 - - - - 0.00000003902 57.0
EH2_k127_4976860_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 349.0
EH2_k127_4976860_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000001645 198.0
EH2_k127_4976860_2 PIN domain of ribonuclease K07060 - - 0.00000000000000000000000000000000000001013 161.0
EH2_k127_4976860_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000001772 54.0
EH2_k127_5031929_0 Methyltransferase K15429 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 363.0
EH2_k127_5031929_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001212 288.0
EH2_k127_5031929_2 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000009266 157.0
EH2_k127_5031929_3 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000006289 149.0
EH2_k127_5031929_4 nucleoside hydrolase - - - 0.00000000000000000001243 109.0
EH2_k127_5055574_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 4.801e-316 975.0
EH2_k127_5055574_1 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 354.0
EH2_k127_5144944_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001025 273.0
EH2_k127_5144944_1 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000006659 190.0
EH2_k127_5144944_2 Belongs to the UPF0146 family K09713 - - 0.00000000000000000000000000000000000000000000009902 177.0
EH2_k127_5159414_1 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0000000000000000000000000005844 115.0
EH2_k127_5159414_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000007349 73.0
EH2_k127_5196905_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 1.386e-211 667.0
EH2_k127_5196905_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 602.0
EH2_k127_5196905_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 307.0
EH2_k127_5196905_3 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000009548 213.0
EH2_k127_5200437_0 AAA-like domain K06915 - - 7.431e-230 723.0
EH2_k127_5200437_1 PFAM formate nitrite transporter K21993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 345.0
EH2_k127_5200437_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.0000000000000000000000000000000000000000000000000000000000003771 217.0
EH2_k127_5200437_3 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.0000000000000000000000000000000000000000000000000003586 189.0
EH2_k127_5210358_0 PFAM type II secretion system protein E K07332 - - 7.418e-277 877.0
EH2_k127_5210358_1 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 438.0
EH2_k127_5210358_2 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 382.0
EH2_k127_5210358_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 284.0
EH2_k127_5210358_4 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000000004072 190.0
EH2_k127_523910_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 376.0
EH2_k127_523910_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008572 230.0
EH2_k127_523910_2 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.00000000004918 65.0
EH2_k127_523910_3 - - - - 0.0001319 53.0
EH2_k127_5297501_0 PFAM Beta propeller domain K14475 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 583.0
EH2_k127_5297501_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 424.0
EH2_k127_5297501_2 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 306.0
EH2_k127_5315919_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 491.0
EH2_k127_5315919_1 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000002136 252.0
EH2_k127_5315919_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000001495 236.0
EH2_k127_5409776_0 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000008726 144.0
EH2_k127_5409776_1 - - - - 0.000000000000000009072 93.0
EH2_k127_5409776_2 Short repeat of unknown function (DUF308) - - - 0.00000000000003819 79.0
EH2_k127_5434684_0 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 303.0
EH2_k127_5434684_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 288.0
EH2_k127_5434684_2 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000007498 184.0
EH2_k127_5498448_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009716 571.0
EH2_k127_5498448_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 346.0
EH2_k127_5498448_2 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001692 269.0
EH2_k127_5498448_3 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001447 260.0
EH2_k127_5560241_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 399.0
EH2_k127_5560241_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 387.0
EH2_k127_5560241_2 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 333.0
EH2_k127_5560241_3 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000001295 226.0
EH2_k127_5560241_4 PFAM ABC transporter K00400 - - 0.0000000000000000000000000000000000000000000000000000000000008535 213.0
EH2_k127_5560241_5 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000000000000000000006157 138.0
EH2_k127_5565_0 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005252 310.0
EH2_k127_5565_1 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 0.000000000000000000000000000000000004769 137.0
EH2_k127_5565_2 Pas domain - - - 0.00000000000000000000000000001544 138.0
EH2_k127_5565_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - 0.000000000000000009701 88.0
EH2_k127_5565_4 Pas domain - - - 0.000000000003687 81.0
EH2_k127_5595359_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008707 406.0
EH2_k127_5595359_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 309.0
EH2_k127_5595359_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000000000000001155 123.0
EH2_k127_5595359_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000001226 54.0
EH2_k127_5610673_0 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 1.068e-301 937.0
EH2_k127_5610673_1 to orf3 of fosmid clone 4B7mr3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004847 280.0
EH2_k127_5610673_2 PFAM Protein kinase domain - - - 0.00001207 49.0
EH2_k127_5613853_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 477.0
EH2_k127_5613853_1 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 319.0
EH2_k127_5613853_2 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000007756 234.0
EH2_k127_5613853_3 protein conserved in archaea K09746 - - 0.000000000000000000000000000000001656 140.0
EH2_k127_5620401_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1191.0
EH2_k127_5620401_1 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000009869 180.0
EH2_k127_5620401_3 Transposase - - - 0.00008191 48.0
EH2_k127_5633948_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1034.0
EH2_k127_5647941_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 492.0
EH2_k127_5647941_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001204 289.0
EH2_k127_5647941_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000004293 99.0
EH2_k127_5647941_3 - - - - 0.000000001551 61.0
EH2_k127_5661737_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004408 278.0
EH2_k127_5661737_1 N-6 DNA Methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005825 267.0
EH2_k127_5737532_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 2.365e-238 749.0
EH2_k127_5737532_1 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 332.0
EH2_k127_5737532_2 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000002382 200.0
EH2_k127_5745726_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.702e-279 878.0
EH2_k127_5745726_1 Involved in regulation of DNA replication K10725 - - 1.643e-201 635.0
EH2_k127_5745726_2 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 565.0
EH2_k127_5745726_3 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000001209 230.0
EH2_k127_5745726_4 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000008967 214.0
EH2_k127_5745726_5 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000000000005194 166.0
EH2_k127_5783750_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 4.388e-276 863.0
EH2_k127_5783750_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003237 281.0
EH2_k127_5783750_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000009727 132.0
EH2_k127_5796897_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1016.0
EH2_k127_5796897_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 610.0
EH2_k127_5819138_0 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 423.0
EH2_k127_5819138_1 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 336.0
EH2_k127_5819138_2 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 304.0
EH2_k127_584636_0 Domain of unknown function (DUF4389) - - - 0.0000000000000000000000000000000000008373 142.0
EH2_k127_584636_1 glucosylceramidase activity - - - 0.0000000000000000000000000000008181 125.0
EH2_k127_584636_2 Ferritin Dps family protein K03594 - 1.16.3.1 0.000000000000000001482 85.0
EH2_k127_584636_3 - - - - 0.0000008651 59.0
EH2_k127_5873267_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000001055 221.0
EH2_k127_5873267_1 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000351 215.0
EH2_k127_5873267_2 Cytochrome C biogenesis protein - - - 0.000000000000000000000000000002317 136.0
EH2_k127_5876672_0 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000007253 268.0
EH2_k127_5876672_1 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000000003776 213.0
EH2_k127_5876672_2 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000000002689 151.0
EH2_k127_5876672_3 CBS domain containing protein - - - 0.0000000000000000000000000000000002701 135.0
EH2_k127_5876672_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000001655 111.0
EH2_k127_5876672_5 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000003491 108.0
EH2_k127_5876672_6 CRS1_YhbY K07574 - - 0.000000000000000000000008842 104.0
EH2_k127_5876672_7 structural constituent of ribosome K02924 - - 0.000000000000000009972 83.0
EH2_k127_5883175_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001333 265.0
EH2_k127_5883175_1 Sodium Bile acid symporter family K03453 - - 0.0000000000000000000000000002953 130.0
EH2_k127_5883175_2 small multi-drug export - - - 0.000000000000000000000005685 117.0
EH2_k127_5923574_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 554.0
EH2_k127_5923574_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009874 552.0
EH2_k127_5923574_2 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 423.0
EH2_k127_5923574_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 338.0
EH2_k127_5923574_4 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000008565 250.0
EH2_k127_5923574_5 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000006343 245.0
EH2_k127_6026940_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 578.0
EH2_k127_6026940_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 328.0
EH2_k127_6026940_2 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 308.0
EH2_k127_6026940_3 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000005066 143.0
EH2_k127_6051808_0 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 353.0
EH2_k127_6051808_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000003876 248.0
EH2_k127_6051808_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001176 234.0
EH2_k127_6081129_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007977 277.0
EH2_k127_6081129_1 PHP-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000001234 234.0
EH2_k127_6081129_2 PFAM Yip1 domain - - - 0.000000000000000000001587 96.0
EH2_k127_6103371_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.791e-209 659.0
EH2_k127_6103371_1 Pfam:DUF552 K09152 - - 0.0000000000000000000000000000000000000000000000000000000001696 205.0
EH2_k127_6103371_2 PFAM PUA domain containing protein K07575 - - 0.00000000000000000000000000000000000000000000000000000002067 201.0
EH2_k127_6103371_3 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000000001717 197.0
EH2_k127_6103371_4 Thioredoxin K03671 - - 0.00000000000000000000000000000000000003621 147.0
EH2_k127_6103371_5 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.00000000000000000000000000000003042 127.0
EH2_k127_6103371_6 binds to the 23S rRNA K02922 - - 0.00000000000000000000000000144 111.0
EH2_k127_6103371_7 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000002375 108.0
EH2_k127_6103371_8 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000001583 68.0
EH2_k127_6116906_0 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 376.0
EH2_k127_6116906_1 ATP-grasp domain K06914 - 6.3.4.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 351.0
EH2_k127_6116906_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000007674 83.0
EH2_k127_6116906_3 - - - - 0.0000000000000001447 85.0
EH2_k127_6125773_0 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 520.0
EH2_k127_6125773_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 284.0
EH2_k127_6125773_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000001752 237.0
EH2_k127_6125773_3 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000005342 158.0
EH2_k127_6125773_4 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000002938 143.0
EH2_k127_6132742_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 387.0
EH2_k127_6132742_1 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000001759 187.0
EH2_k127_6132742_2 Protein of unknown function DUF58 - - - 0.0000000001388 65.0
EH2_k127_6183924_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1041.0
EH2_k127_6183924_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.947e-292 910.0
EH2_k127_6183924_2 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 516.0
EH2_k127_6183924_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 430.0
EH2_k127_6183924_4 PFAM glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 390.0
EH2_k127_6183924_5 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000001946 149.0
EH2_k127_6252240_0 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 373.0
EH2_k127_6252240_1 Domain of unknown function (DUF1917) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 312.0
EH2_k127_6252240_2 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000002368 227.0
EH2_k127_6252240_3 - - - - 0.00000005622 55.0
EH2_k127_6288562_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 5.149e-289 897.0
EH2_k127_6288562_1 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 375.0
EH2_k127_6288562_2 methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 373.0
EH2_k127_6288562_3 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000003261 244.0
EH2_k127_6288562_4 Uncharacterized protein conserved in archaea (DUF2180) - - - 0.0000000000000000000000000004646 115.0
EH2_k127_6326158_0 epimerase dehydratase family K01784,K08679 - 5.1.3.2,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 307.0
EH2_k127_6326158_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000004107 157.0
EH2_k127_6326158_2 Cytidylyltransferase - - - 0.000000000000000000000000000000000005813 140.0
EH2_k127_6326158_3 oxidoreductase - - - 0.00000000000000000005224 102.0
EH2_k127_6363904_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 2.668e-196 620.0
EH2_k127_6363904_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 408.0
EH2_k127_63955_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 3.6.3.54 2.173e-195 621.0
EH2_k127_63955_1 cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 486.0
EH2_k127_63955_2 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000000003953 94.0
EH2_k127_6403341_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 574.0
EH2_k127_6403341_1 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 546.0
EH2_k127_6403341_2 Desulfoferrodoxin, N-terminal domain K05919 - 1.15.1.2 0.000000000000000000000000000000000021 149.0
EH2_k127_6403341_3 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000001938 64.0
EH2_k127_6431248_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.448e-210 661.0
EH2_k127_6431248_1 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 353.0
EH2_k127_6431248_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000392 233.0
EH2_k127_6431248_3 TIGRFAM desulfoferrodoxin FeS4 iron-binding domain K05919 - 1.15.1.2 0.000000000000000000000000000001561 123.0
EH2_k127_6454530_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 446.0
EH2_k127_6454530_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 372.0
EH2_k127_6454530_2 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 328.0
EH2_k127_6454530_3 PFAM Cation K03498 - - 0.000000000000000000000565 102.0
EH2_k127_6460830_0 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000000000000000000000000000006648 171.0
EH2_k127_6460830_1 PFAM peptidase U32 K08303 - - 0.0000000000000000000141 94.0
EH2_k127_6460830_2 WD40 repeats - - - 0.000000001022 71.0
EH2_k127_6460830_3 TIGRFAM phosphodiesterase, MJ0936 family K07095 - - 0.00001359 48.0
EH2_k127_6479196_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002277 281.0
EH2_k127_6479196_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004748 275.0
EH2_k127_6479196_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005776 262.0
EH2_k127_6479196_3 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000002262 132.0
EH2_k127_6479196_4 - - - - 0.0000000000000000007618 96.0
EH2_k127_6505364_0 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000003658 271.0
EH2_k127_652358_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 490.0
EH2_k127_652358_1 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007952 274.0
EH2_k127_652358_2 metal-binding protein - - - 0.000000000000000000000001297 110.0
EH2_k127_6554003_0 LOR SDH bifunctional enzyme conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 396.0
EH2_k127_6554003_1 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 359.0
EH2_k127_6554003_2 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000001412 202.0
EH2_k127_6561597_0 LOR SDH bifunctional enzyme conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 486.0
EH2_k127_6561597_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 405.0
EH2_k127_6564902_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 5.981e-242 752.0
EH2_k127_6564902_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 561.0
EH2_k127_6564902_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008355 464.0
EH2_k127_6564902_3 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 392.0
EH2_k127_6564902_4 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007283 358.0
EH2_k127_6564902_5 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 342.0
EH2_k127_6564902_6 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000478 197.0
EH2_k127_6564902_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000003538 66.0
EH2_k127_6564902_8 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000009615 68.0
EH2_k127_6609585_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 6.4e-250 780.0
EH2_k127_6609585_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 362.0
EH2_k127_661976_0 SMART Elongator protein 3 MiaB NifB - - - 1.249e-235 744.0
EH2_k127_661976_1 - - - - 0.00000000000000000006483 96.0
EH2_k127_669273_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 548.0
EH2_k127_669273_1 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008983 321.0
EH2_k127_669273_2 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 286.0
EH2_k127_669273_3 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.00000000000000000000000000000000000009748 142.0
EH2_k127_669273_4 - - - - 0.0000000000000000000000000000001313 126.0
EH2_k127_669273_5 Transglutaminase-like superfamily - - - 0.000000000000000000000000002883 123.0
EH2_k127_6708785_0 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 577.0
EH2_k127_6708785_1 TIGRFAM MIP family channel K02440,K06188 - - 0.000000000000000000000000000000000000000001451 159.0
EH2_k127_6728540_0 SMART Elongator protein 3 MiaB NifB - - - 1.625e-232 731.0
EH2_k127_6728540_1 phosphoesterase RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008399 497.0
EH2_k127_6728540_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 455.0
EH2_k127_6728540_3 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001346 259.0
EH2_k127_6728540_4 PFAM PRC-barrel domain - - - 0.000000000000000000000000008483 111.0
EH2_k127_6746756_0 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000003554 253.0
EH2_k127_6769452_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 6.039e-215 681.0
EH2_k127_6769452_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 338.0
EH2_k127_6769452_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002171 278.0
EH2_k127_67884_0 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 391.0
EH2_k127_67884_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000002135 214.0
EH2_k127_67884_2 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000685 114.0
EH2_k127_6797807_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 455.0
EH2_k127_6797807_1 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009818 402.0
EH2_k127_6806341_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 9.979e-194 613.0
EH2_k127_6806341_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005558 274.0
EH2_k127_6806341_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000003042 160.0
EH2_k127_6810303_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 396.0
EH2_k127_6810303_1 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 344.0
EH2_k127_6810303_2 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000000000000000000001365 155.0
EH2_k127_6810303_3 - - - - 0.00000000000000000000000001006 112.0
EH2_k127_6823804_0 Involved in cell shape control K22222 - - 1.164e-211 662.0
EH2_k127_6823804_1 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 530.0
EH2_k127_6823804_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 415.0
EH2_k127_6823804_3 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008175 325.0
EH2_k127_6823804_4 - - - - 0.00000000000000000000000000000000000000000002812 177.0
EH2_k127_6861818_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000007499 151.0
EH2_k127_6861818_1 Tetratricopeptide repeat - - - 0.000000000000000000000000001581 123.0
EH2_k127_6861818_2 CpXC protein - - - 0.000000000000004369 81.0
EH2_k127_6870388_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 2.667e-260 816.0
EH2_k127_6870388_1 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 334.0
EH2_k127_6870388_2 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000009615 232.0
EH2_k127_6870388_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000008084 228.0
EH2_k127_6870388_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000005084 197.0
EH2_k127_6870388_5 COG2406 Protein distantly related to bacterial ferritins K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000006318 188.0
EH2_k127_6870388_6 - - - - 0.000000000000000000000000000000003357 132.0
EH2_k127_6870388_7 PFAM Bacterial protein of - - - 0.00000000000005641 81.0
EH2_k127_6886255_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 9.322e-249 790.0
EH2_k127_688995_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 469.0
EH2_k127_688995_1 Belongs to the peptidase S8 family K01342 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030193,GO:0030195,GO:0032101,GO:0032102,GO:0042730,GO:0043170,GO:0044238,GO:0048519,GO:0048583,GO:0048585,GO:0050789,GO:0050818,GO:0050819,GO:0050878,GO:0051239,GO:0051241,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0080134,GO:0140096,GO:1900046,GO:1900047,GO:1901564,GO:1903034,GO:1903035 3.4.21.62 0.000000000000000000000773 105.0
EH2_k127_6904458_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.378e-202 639.0
EH2_k127_6904458_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.36e-199 630.0
EH2_k127_6904458_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 392.0
EH2_k127_6904458_3 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 291.0
EH2_k127_6904458_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000003926 101.0
EH2_k127_6916686_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1062.0
EH2_k127_6916686_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 1.313e-294 910.0
EH2_k127_6916686_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 373.0
EH2_k127_6916686_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000007876 122.0
EH2_k127_6916686_4 Phosphate-starvation-inducible E - - - 0.0000000000000003777 85.0
EH2_k127_6930059_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 541.0
EH2_k127_6930059_1 Protein of unknown function (DUF475) K09799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 432.0
EH2_k127_6930059_2 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000104 275.0
EH2_k127_6930059_3 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.0000000000000000000000000000000000000000000000000000000000000209 221.0
EH2_k127_6930059_4 nucleic acid binding OB-fold tRNA helicase-type - - - 0.000000000000000000000001371 108.0
EH2_k127_6930059_5 Anion transporter K14445 - - 0.0000000000000000008978 89.0
EH2_k127_6948897_0 - - - - 0.000000000000000000000000000000000000000000000000004379 188.0
EH2_k127_6948897_1 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000009391 177.0
EH2_k127_6948897_2 - - - - 0.0000000000000000000000000001474 119.0
EH2_k127_6948897_3 Cobalt transport protein K02008 - - 0.000000000000000000000000009298 113.0
EH2_k127_6954727_0 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 579.0
EH2_k127_6954727_1 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002702 264.0
EH2_k127_6954727_2 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003598 263.0
EH2_k127_6954727_3 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000001011 220.0
EH2_k127_6954727_4 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000001873 179.0
EH2_k127_6954727_5 Permease - - - 0.000000000000000000000000000000000004149 150.0
EH2_k127_6954727_6 - - - - 0.00000000000000000007224 93.0
EH2_k127_6964538_0 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000001013 257.0
EH2_k127_6964538_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000001598 172.0
EH2_k127_7010501_0 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 386.0
EH2_k127_7010501_1 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000001081 227.0
EH2_k127_7014933_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 507.0
EH2_k127_7014933_1 TfuA-like protein - - - 0.000000000000000000000000000000000000001811 154.0
EH2_k127_7014933_2 NAD synthase K06864 - - 0.00000000000000008395 81.0
EH2_k127_7047964_0 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 414.0
EH2_k127_7047964_1 glycosyl transferase, family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 384.0
EH2_k127_7071777_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000003743 183.0
EH2_k127_7071777_1 - - - - 0.000000000000000000007002 104.0
EH2_k127_7117450_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.42e-235 752.0
EH2_k127_7117450_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 296.0
EH2_k127_7117450_2 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000000004697 104.0
EH2_k127_7117450_3 - - - - 0.0000002512 58.0
EH2_k127_7123743_0 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 383.0
EH2_k127_7123743_1 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000002173 200.0
EH2_k127_7123743_2 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000024 168.0
EH2_k127_7123743_3 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000007255 136.0
EH2_k127_7123743_4 - - - - 0.00000000000000000000000000000001368 129.0
EH2_k127_7123743_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.0000000000000145 75.0
EH2_k127_7123743_6 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000003974 73.0
EH2_k127_7153451_0 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 339.0
EH2_k127_7182728_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 461.0
EH2_k127_7182728_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002075 242.0
EH2_k127_7182728_2 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000002368 190.0
EH2_k127_7182728_3 RuvA, C-terminal domain K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000002358 185.0
EH2_k127_7200164_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 410.0
EH2_k127_7200164_1 Roadblock LC7 K07131 - - 0.000000000000000000000000000000000000000000000000005676 183.0
EH2_k127_7200164_2 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000003213 141.0
EH2_k127_7200164_3 - - - - 0.0000001765 61.0
EH2_k127_7263942_0 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000002696 232.0
EH2_k127_7263942_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
EH2_k127_7263942_2 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000000000000000000000000000001114 220.0
EH2_k127_7263942_3 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000427 160.0
EH2_k127_7296521_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 286.0
EH2_k127_7296521_1 ATP synthase subunit K K02124 - - 0.00000000000000000000000000000000000000000000002189 174.0
EH2_k127_7296521_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000007679 180.0
EH2_k127_7296521_3 V-type ATP synthase, subunit I K02123 - - 0.00000000000000000000000000001494 122.0
EH2_k127_7296521_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000005415 51.0
EH2_k127_7399807_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 2.57e-322 1004.0
EH2_k127_7399807_1 PFAM amino acid permease-associated region K20265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 320.0
EH2_k127_7399807_2 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000007176 53.0
EH2_k127_7416479_0 Thiopurine S-methyltransferase (TPMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001002 259.0
EH2_k127_7416479_1 PHP-associated - - - 0.000000000000000000000001375 106.0
EH2_k127_7416479_2 Acid phosphatase homologues - - - 0.000000000000000000004927 101.0
EH2_k127_744167_0 Deoxyribodipyrimidine photo-lyase-related protein K06876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 323.0
EH2_k127_7467198_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 546.0
EH2_k127_7467198_1 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 467.0
EH2_k127_7467198_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 420.0
EH2_k127_7467198_3 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 368.0
EH2_k127_7467198_4 - - - - 0.000000000000000000000000000000000000000002935 162.0
EH2_k127_7468634_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005981 588.0
EH2_k127_7468634_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009671 398.0
EH2_k127_7468634_2 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000001372 105.0
EH2_k127_7468634_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.000000000000000000003022 94.0
EH2_k127_7492455_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 527.0
EH2_k127_7492455_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000002442 226.0
EH2_k127_7492455_2 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000000000000000000000000000000000000000002182 220.0
EH2_k127_7519478_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 453.0
EH2_k127_7519478_1 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 385.0
EH2_k127_7519478_2 Putative small multi-drug export protein - - - 0.0000000005207 62.0
EH2_k127_7585061_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.224e-296 917.0
EH2_k127_7585061_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 3.029e-256 798.0
EH2_k127_7585061_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 287.0
EH2_k127_7585061_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001149 278.0
EH2_k127_7585061_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.00000005669 59.0
EH2_k127_7631098_0 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004188 309.0
EH2_k127_7631098_1 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000006236 169.0
EH2_k127_7631098_2 - - - - 0.00002025 51.0
EH2_k127_7631098_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000267 45.0
EH2_k127_770263_0 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 360.0
EH2_k127_770263_1 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000153 234.0
EH2_k127_770263_2 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000000005655 169.0
EH2_k127_770263_3 - - - - 0.000000000000000000000000000000002202 139.0
EH2_k127_770263_4 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000000000000000000005575 122.0
EH2_k127_770263_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.00000000000000000000000001573 113.0
EH2_k127_7804015_0 PFAM NAD dependent epimerase dehydratase family K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 398.0
EH2_k127_7804015_1 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005467 264.0
EH2_k127_7804015_2 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000000000002196 155.0
EH2_k127_7812556_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 464.0
EH2_k127_7812556_1 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006684 276.0
EH2_k127_7812556_2 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004744 270.0
EH2_k127_7812556_3 SPFH Band 7 PHB domain protein - - - 0.00000000000003624 77.0
EH2_k127_7812615_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 564.0
EH2_k127_7812615_1 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001638 250.0
EH2_k127_7812615_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000000000000000000005162 207.0
EH2_k127_7812615_3 SMART regulatory protein AsnC Lrp family K22225 - - 0.000000000000000000000000000000000000000000000002337 181.0
EH2_k127_7812615_4 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.000000000000000000000000001612 111.0
EH2_k127_7815397_0 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 430.0
EH2_k127_7815397_1 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 310.0
EH2_k127_7815397_2 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000004973 185.0
EH2_k127_7854760_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 405.0
EH2_k127_7854760_1 Belongs to the N(4) N(6)-methyltransferase family K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000002204 153.0
EH2_k127_7854760_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000161 82.0
EH2_k127_7937043_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 2.207e-217 681.0
EH2_k127_7937043_1 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 443.0
EH2_k127_7937043_2 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000035 229.0
EH2_k127_7937043_3 DNA ligase D, 3-phosphoesterase domain - - - 0.0000000000000000000000000000000000000000000000000007339 188.0
EH2_k127_7937043_4 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000003277 174.0
EH2_k127_7937043_5 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.000000000000000000000002731 102.0
EH2_k127_7997721_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 372.0
EH2_k127_7997721_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 314.0
EH2_k127_7997721_2 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006892 303.0
EH2_k127_7997721_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005385 299.0
EH2_k127_7997721_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000003924 255.0
EH2_k127_7997721_5 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000008739 201.0
EH2_k127_7997721_6 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000000000001488 182.0
EH2_k127_7997721_7 Sodium/hydrogen exchanger family K03455 - - 0.000000000000000000000000574 118.0
EH2_k127_7997721_8 PFAM elongation factor Tu domain 2 - - - 0.000000000000000000013 92.0
EH2_k127_7997721_9 - - - - 0.00000000000002749 79.0
EH2_k127_8001094_0 Belongs to the RtcB family K14415 - 6.5.1.3 7.485e-219 687.0
EH2_k127_8001094_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 332.0
EH2_k127_8001094_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001398 229.0
EH2_k127_8001094_3 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000009046 215.0
EH2_k127_8001094_4 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000000000000000000000000000000000653 201.0
EH2_k127_8001094_5 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000001526 182.0
EH2_k127_8001094_6 - - - - 0.0000000000000000000000002493 108.0
EH2_k127_8001094_7 Protein of unknown function (DUF2551) - - - 0.0000000000000000000009247 100.0
EH2_k127_8001094_8 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000002581 81.0
EH2_k127_8013284_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 317.0
EH2_k127_8013284_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 318.0
EH2_k127_8013284_2 - - - - 0.0000000000000000000000000000000000000000000000000000001783 199.0
EH2_k127_8013284_3 - - - - 0.0000000000000000000000000000007812 123.0
EH2_k127_8018566_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 518.0
EH2_k127_8018566_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 377.0
EH2_k127_8018566_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000009661 208.0
EH2_k127_8018566_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000002247 133.0
EH2_k127_8042460_0 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 552.0
EH2_k127_8042460_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 499.0
EH2_k127_8042460_2 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 386.0
EH2_k127_8042460_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 340.0
EH2_k127_8042460_4 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 316.0
EH2_k127_8042460_5 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000000006539 224.0
EH2_k127_8042460_6 protein possibly involved in aromatic compounds catabolism K02614 - - 0.0000000000000000000000007207 108.0
EH2_k127_8042460_7 PBS lyase HEAT-like repeat - - - 0.00000000000000000001104 99.0
EH2_k127_8042460_8 PFAM amine oxidase - - - 0.00000009445 53.0
EH2_k127_8055571_0 domain, Protein K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 399.0
EH2_k127_8055571_1 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009087 256.0
EH2_k127_8055571_2 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000001226 217.0
EH2_k127_8055571_3 Belongs to the serpin family K13963 GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044421,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772 - 0.000000000000000002989 89.0
EH2_k127_8059468_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 1.3e-322 1000.0
EH2_k127_8059468_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000006252 231.0
EH2_k127_8059468_2 HAD-hyrolase-like K07025 - - 0.00000000000000000000000000000000000000000000000000001271 198.0
EH2_k127_8059468_3 Sodium:neurotransmitter symporter family K03308 - - 0.000000000000000000001118 98.0
EH2_k127_8063198_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 339.0
EH2_k127_8063198_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 287.0
EH2_k127_8063198_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000001912 210.0
EH2_k127_8063198_3 - - - - 0.000000000000000000001093 104.0
EH2_k127_8063198_4 Belongs to the UPF0434 family - - - 0.000000000000000000002938 94.0
EH2_k127_80769_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 2.804e-275 872.0
EH2_k127_80769_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 7.773e-209 657.0
EH2_k127_80769_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 503.0
EH2_k127_80769_3 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 470.0
EH2_k127_80769_4 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 390.0
EH2_k127_80769_5 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000005174 221.0
EH2_k127_80769_6 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00000000000003191 84.0
EH2_k127_8167683_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 435.0
EH2_k127_8167683_1 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000000000000002091 164.0
EH2_k127_8172922_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.1e-267 832.0
EH2_k127_8172922_1 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 297.0
EH2_k127_8172922_2 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 252.0
EH2_k127_8172922_3 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000008695 190.0
EH2_k127_8196460_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 452.0
EH2_k127_8196460_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 392.0
EH2_k127_8196460_2 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007145 345.0
EH2_k127_8196460_3 Domain of unknown function (DUF4962) - - - 0.0000000000000000000001125 114.0
EH2_k127_8210561_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002676 245.0
EH2_k127_8210561_1 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001677 228.0
EH2_k127_822526_0 Domain of unknown function DUF87 - - - 0.0000000000000000000003135 103.0
EH2_k127_822526_1 Triacylglycerol lipase K01046 - 3.1.1.3 0.00002122 57.0
EH2_k127_829463_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 530.0
EH2_k127_829463_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 477.0
EH2_k127_829463_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000001041 222.0
EH2_k127_829463_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000003223 147.0
EH2_k127_841822_0 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 289.0
EH2_k127_841822_1 archaeal Zn-finger protein - - - 0.00000000000000000000000000000000000000000000000000001556 194.0
EH2_k127_841822_2 Domain of unknown function (DUF371) K09738 - - 0.000000000000000000000000000000000000000000000007472 175.0
EH2_k127_841822_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000004388 162.0
EH2_k127_841822_4 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000005226 113.0
EH2_k127_841822_5 - - - - 0.00000000000000000002229 100.0
EH2_k127_896157_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 599.0
EH2_k127_896157_1 von Willebrand factor type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 334.0
EH2_k127_896157_2 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 297.0
EH2_k127_896157_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000007237 141.0
EH2_k127_896157_4 - - - - 0.0000000000000000000000000000005989 126.0
EH2_k127_903666_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 4.911e-203 640.0
EH2_k127_903666_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005665 263.0
EH2_k127_903666_2 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000596 143.0
EH2_k127_903666_3 - - - - 0.000000000000000002521 91.0
EH2_k127_9049_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 4.182e-228 714.0
EH2_k127_9049_1 PFAM SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000000005982 169.0
EH2_k127_9049_2 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.000000000000000000000000000000000000000000319 167.0
EH2_k127_919139_0 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 340.0
EH2_k127_919139_1 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008808 255.0
EH2_k127_919139_2 Belongs to the UPF0212 family K09731 - - 0.00000000000000000000000000000000000000000000002656 175.0
EH2_k127_919139_3 Family of unknown function (DUF5350) - - - 0.0000000000000000000000004693 107.0
EH2_k127_923489_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 376.0
EH2_k127_923489_1 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 311.0
EH2_k127_923489_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000003976 53.0
EH2_k127_928507_0 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000000000006866 220.0
EH2_k127_928507_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000001146 118.0
EH2_k127_928507_2 PFAM Glutaredoxin - - - 0.0000000000000000000000000002478 117.0
EH2_k127_92966_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 7.012e-195 618.0
EH2_k127_92966_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 445.0
EH2_k127_92966_2 - - - - 0.00000000000000000000000000000000001372 145.0
EH2_k127_92966_3 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000006092 127.0
EH2_k127_938327_0 Pfam:DUF650 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 499.0
EH2_k127_938327_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 423.0
EH2_k127_938327_2 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001564 233.0
EH2_k127_938327_3 - - - - 0.00000000000000000000000000000001255 133.0
EH2_k127_938327_4 Ferredoxin K05337 - - 0.000000000000000000000004082 104.0
EH2_k127_938327_5 Ferredoxin K05337 - - 0.000000000000001636 79.0
EH2_k127_938327_6 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.000000000001177 74.0
EH2_k127_938327_7 Belongs to the UPF0216 family K09737 - - 0.00000006699 59.0
EH2_k127_947308_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 2.004e-315 975.0
EH2_k127_947308_1 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 604.0
EH2_k127_947308_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 591.0
EH2_k127_947308_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 402.0
EH2_k127_952192_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008599 450.0
EH2_k127_952192_1 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 322.0
EH2_k127_952192_2 amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000435 215.0
EH2_k127_952192_3 Hydrogenase maturation protease K03605 - - 0.00000000000000000000000001533 113.0