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Overview

ID MAG01630
Name HFD2_bin.12
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Blastocatellia
Order Pyrinomonadales
Family Pyrinomonadaceae
Genus PSRF01
Species
Assembly information
Completeness (%) 97.86
Contamination (%) 0.57
GC content (%) 56.0
N50 (bp) 53,494
Genome size (bp) 4,907,493

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3737

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1007654_0 Cytochrome c - - - 0.0 1242.0
HFD2_k127_1007654_1 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01535 - 3.6.3.6 2.278e-293 923.0
HFD2_k127_1007654_10 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 560.0
HFD2_k127_1007654_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 536.0
HFD2_k127_1007654_12 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 517.0
HFD2_k127_1007654_13 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 496.0
HFD2_k127_1007654_14 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 415.0
HFD2_k127_1007654_15 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 395.0
HFD2_k127_1007654_16 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 351.0
HFD2_k127_1007654_17 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002441 282.0
HFD2_k127_1007654_18 HlyD family secretion protein K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006273 289.0
HFD2_k127_1007654_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001734 256.0
HFD2_k127_1007654_2 Zinc-binding dehydrogenase - - - 4.511e-293 917.0
HFD2_k127_1007654_20 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004464 251.0
HFD2_k127_1007654_21 - - - - 0.0000000000000000000000000000000000000000000000000000000000000007424 227.0
HFD2_k127_1007654_22 NnrS protein - - - 0.000000000000000000000000000000000000000000000000000000000000001647 235.0
HFD2_k127_1007654_23 - - - - 0.000000000000000000000000000000000000000000000000000000000001917 211.0
HFD2_k127_1007654_24 Protein of unknown function (DUF3179) - - - 0.0000000000000000000000000000000000000000000000000000000009603 209.0
HFD2_k127_1007654_25 HAD-hyrolase-like K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000001228 197.0
HFD2_k127_1007654_26 - - - - 0.0000000000000000000000000000000000000000000002612 171.0
HFD2_k127_1007654_27 BON domain - - - 0.00000000000000000000000000000000000000000001068 170.0
HFD2_k127_1007654_28 - - - - 0.000000000000000000000000000000000000000003372 157.0
HFD2_k127_1007654_29 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000004376 146.0
HFD2_k127_1007654_3 GMC oxidoreductase - - - 4.368e-287 892.0
HFD2_k127_1007654_30 Universal stress protein family - - - 0.00000000000000000000000000005308 129.0
HFD2_k127_1007654_31 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin - - - 0.00000000000000000000000000009719 126.0
HFD2_k127_1007654_32 PFAM Uncharacterised BCR, COG1649 - - - 0.00000000000000000000000001502 128.0
HFD2_k127_1007654_33 Protein of unknown function with PCYCGC motif - - - 0.00000000000000000006483 96.0
HFD2_k127_1007654_34 AMP binding - - - 0.0000000000000000001398 100.0
HFD2_k127_1007654_36 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000007768 91.0
HFD2_k127_1007654_38 YtkA-like - - - 0.0000000000000003155 85.0
HFD2_k127_1007654_39 COG1874 Beta-galactosidase K04753,K12567 - 2.7.11.1 0.000000000005125 80.0
HFD2_k127_1007654_4 repeat protein - - - 3.792e-280 877.0
HFD2_k127_1007654_41 Peptidase M16 inactive domain - - - 0.000000000169 72.0
HFD2_k127_1007654_42 Universal stress protein family - - - 0.0000000001862 72.0
HFD2_k127_1007654_44 Family of unknown function (DUF5335) - - - 0.0000002415 57.0
HFD2_k127_1007654_45 membrane - - - 0.0002886 51.0
HFD2_k127_1007654_46 Transglycosylase SLT domain - - - 0.0008485 51.0
HFD2_k127_1007654_5 ABC-type transport system involved in lipoprotein release permease component K02004 - - 7.565e-279 878.0
HFD2_k127_1007654_6 peptide catabolic process - - - 2.125e-230 726.0
HFD2_k127_1007654_7 iron assimilation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 614.0
HFD2_k127_1007654_8 catalase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 582.0
HFD2_k127_1007654_9 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 582.0
HFD2_k127_1034600_0 Tricorn protease C1 domain K08676 - - 0.0 1265.0
HFD2_k127_1034600_1 Succinyl-CoA ligase like flavodoxin domain - - - 1.954e-320 1006.0
HFD2_k127_1034600_10 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 342.0
HFD2_k127_1034600_11 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002938 267.0
HFD2_k127_1034600_12 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000003478 241.0
HFD2_k127_1034600_13 aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000008291 219.0
HFD2_k127_1034600_14 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000001302 210.0
HFD2_k127_1034600_15 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000000000000000000000000000000000000000000000000001229 202.0
HFD2_k127_1034600_17 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000000003095 179.0
HFD2_k127_1034600_18 Beta-lactamase - - - 0.0000000000000000000000000000000000000000104 158.0
HFD2_k127_1034600_2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 1.246e-230 730.0
HFD2_k127_1034600_20 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000007518 118.0
HFD2_k127_1034600_21 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000007884 108.0
HFD2_k127_1034600_22 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.0000000000000000000000271 105.0
HFD2_k127_1034600_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 1.14e-223 708.0
HFD2_k127_1034600_4 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 621.0
HFD2_k127_1034600_5 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 583.0
HFD2_k127_1034600_6 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 552.0
HFD2_k127_1034600_7 Zinc-binding alcohol dehydrogenase family protein K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 412.0
HFD2_k127_1034600_8 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 407.0
HFD2_k127_1034600_9 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 356.0
HFD2_k127_1049714_0 Sortilin, neurotensin receptor 3, - - - 0.0 1335.0
HFD2_k127_1049714_1 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09014 - - 7.164e-256 794.0
HFD2_k127_1049714_10 ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 537.0
HFD2_k127_1049714_11 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 483.0
HFD2_k127_1049714_12 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 476.0
HFD2_k127_1049714_13 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 460.0
HFD2_k127_1049714_14 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 456.0
HFD2_k127_1049714_15 PFAM Glycosyl transferase, family K00756 - 2.4.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007306 417.0
HFD2_k127_1049714_16 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 406.0
HFD2_k127_1049714_17 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 404.0
HFD2_k127_1049714_18 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 404.0
HFD2_k127_1049714_19 ATPase activity K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006501 380.0
HFD2_k127_1049714_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.984e-251 798.0
HFD2_k127_1049714_20 COGs COG4299 conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 380.0
HFD2_k127_1049714_21 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008522 370.0
HFD2_k127_1049714_22 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 361.0
HFD2_k127_1049714_23 4Fe-4S dicluster domain K17723 - 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 339.0
HFD2_k127_1049714_24 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 336.0
HFD2_k127_1049714_25 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 369.0
HFD2_k127_1049714_26 PFAM Basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 334.0
HFD2_k127_1049714_27 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 328.0
HFD2_k127_1049714_28 neuron death in response to oxidative stress K01173,K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 358.0
HFD2_k127_1049714_29 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 304.0
HFD2_k127_1049714_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.379e-224 702.0
HFD2_k127_1049714_30 Exodeoxyribonuclease iii K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 302.0
HFD2_k127_1049714_31 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 309.0
HFD2_k127_1049714_32 PFAM Branched-chain amino acid transport system permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 302.0
HFD2_k127_1049714_33 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002091 287.0
HFD2_k127_1049714_34 Peptidase dimerisation domain K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001545 290.0
HFD2_k127_1049714_35 DNA/RNA non-specific endonuclease K01173 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002572 290.0
HFD2_k127_1049714_36 Phosphoribulokinase / Uridine kinase family K00855,K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000001633 256.0
HFD2_k127_1049714_37 PFAM monooxygenase FAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002546 261.0
HFD2_k127_1049714_38 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001176 244.0
HFD2_k127_1049714_39 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000004606 219.0
HFD2_k127_1049714_4 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 6.286e-205 653.0
HFD2_k127_1049714_40 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.0000000000000000000000000000000000000000000000000000006331 222.0
HFD2_k127_1049714_41 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.000000000000000000000000000000000000000000000000000001083 196.0
HFD2_k127_1049714_42 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000006798 197.0
HFD2_k127_1049714_43 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000004037 190.0
HFD2_k127_1049714_44 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000005393 176.0
HFD2_k127_1049714_45 - - - - 0.00000000000000000000000000000000000000000000001122 174.0
HFD2_k127_1049714_46 domain protein - - - 0.00000000000000000000000000000000000000000000004862 197.0
HFD2_k127_1049714_47 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.00000000000000000000000000000000000000000007966 164.0
HFD2_k127_1049714_48 - - - - 0.0000000000000000000000000000000000000000001091 177.0
HFD2_k127_1049714_49 Transcriptional repressor, CopY family - - - 0.000000000000000000000000000000000000000001451 159.0
HFD2_k127_1049714_5 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 609.0
HFD2_k127_1049714_50 arogenate dehydratase activity K05359,K20102 GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009637,GO:0009642,GO:0009645,GO:0009987,GO:0010244,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047769,GO:0050896,GO:0071704,GO:0080167,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,4.2.1.91 0.0000000000000000000000000000000000000003232 158.0
HFD2_k127_1049714_51 domain protein - - - 0.0000000000000000000000000000000000000007848 173.0
HFD2_k127_1049714_52 - - - - 0.000000000000000000000000000000000000001783 151.0
HFD2_k127_1049714_53 Thiol-disulfide oxidoreductase DCC - - - 0.000000000000000000000000000000000003036 141.0
HFD2_k127_1049714_54 Lamin Tail Domain - - - 0.00000000000000000000000000000000001208 159.0
HFD2_k127_1049714_55 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000006809 135.0
HFD2_k127_1049714_56 Protein of unknown function, DUF393 - - - 0.000000000000000000000000000006971 122.0
HFD2_k127_1049714_57 transcriptional regulator - - - 0.0000000000000000000000001348 111.0
HFD2_k127_1049714_58 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000729 102.0
HFD2_k127_1049714_59 DinB superfamily - - - 0.000000000000000000176 88.0
HFD2_k127_1049714_6 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 590.0
HFD2_k127_1049714_60 PFAM Chorismate mutase, type II - - - 0.0000000000008661 71.0
HFD2_k127_1049714_61 - - - - 0.000000000007837 72.0
HFD2_k127_1049714_62 Transcriptional regulator K07979 - - 0.000000002085 61.0
HFD2_k127_1049714_63 Peptidase, M56 - - - 0.000000923 61.0
HFD2_k127_1049714_7 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 596.0
HFD2_k127_1049714_8 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 586.0
HFD2_k127_1049714_9 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 544.0
HFD2_k127_1088496_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0 1067.0
HFD2_k127_1088496_1 Hydrolase CocE NonD family - - - 6.633e-313 967.0
HFD2_k127_1088496_10 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 447.0
HFD2_k127_1088496_11 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 429.0
HFD2_k127_1088496_12 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 441.0
HFD2_k127_1088496_13 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 420.0
HFD2_k127_1088496_14 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 415.0
HFD2_k127_1088496_15 CarboxypepD_reg-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 389.0
HFD2_k127_1088496_16 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000001479 231.0
HFD2_k127_1088496_17 Protein of unknown function (DUF541) K09797 - - 0.00000000000000000000000000000000000000000000000000000000000003489 223.0
HFD2_k127_1088496_18 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000008125 203.0
HFD2_k127_1088496_19 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000002882 186.0
HFD2_k127_1088496_2 PFAM ABC transporter related K06020 - 3.6.3.25 8.978e-307 945.0
HFD2_k127_1088496_20 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000002984 188.0
HFD2_k127_1088496_21 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000003623 178.0
HFD2_k127_1088496_22 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000004513 166.0
HFD2_k127_1088496_23 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000000000000000007087 166.0
HFD2_k127_1088496_24 transcriptional regulator - - - 0.000000000000000000000000000000000003216 149.0
HFD2_k127_1088496_25 PHP domain protein - - - 0.000000000000000000000000000000000007787 150.0
HFD2_k127_1088496_26 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.0000000000000000000001473 102.0
HFD2_k127_1088496_27 Putative phosphatase (DUF442) - - - 0.0000000000000002352 94.0
HFD2_k127_1088496_28 - - - - 0.000000000000002711 80.0
HFD2_k127_1088496_29 Thioesterase superfamily - - - 0.000000000000002927 80.0
HFD2_k127_1088496_3 N-acetyldiaminopimelate deacetylase activity K12941 - - 3.079e-244 763.0
HFD2_k127_1088496_30 Protein of unknown function (DUF983) - - - 0.0000000002707 67.0
HFD2_k127_1088496_31 lytic transglycosylase activity K03194 - - 0.00000009662 64.0
HFD2_k127_1088496_32 - - - - 0.000003068 51.0
HFD2_k127_1088496_4 Carboxypeptidase regulatory-like domain - - - 1.525e-194 643.0
HFD2_k127_1088496_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 615.0
HFD2_k127_1088496_6 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 584.0
HFD2_k127_1088496_7 ABC transporter, transmembrane K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 569.0
HFD2_k127_1088496_8 ABC transporter transmembrane region K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 554.0
HFD2_k127_1088496_9 Peptidase, S9A B C family, catalytic domain protein K01303 - 3.4.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 500.0
HFD2_k127_1095406_0 PFAM Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 616.0
HFD2_k127_1095406_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 539.0
HFD2_k127_1095406_10 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000983 275.0
HFD2_k127_1095406_11 peptidyl-tyrosine sulfation K03217,K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000152 274.0
HFD2_k127_1095406_12 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
HFD2_k127_1095406_13 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000005086 198.0
HFD2_k127_1095406_14 Lecithin:cholesterol acyltransferase - - - 0.00000000000000000000000000000000000000000000000003147 197.0
HFD2_k127_1095406_15 - - - - 0.0000000000000000000000000000000000000000000000001912 190.0
HFD2_k127_1095406_16 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000001738 181.0
HFD2_k127_1095406_17 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000004053 158.0
HFD2_k127_1095406_18 galactose-6-phosphate isomerase activity K00761,K01808 - 2.4.2.9,5.3.1.6 0.00000000000000000000000000000000000001202 160.0
HFD2_k127_1095406_19 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000000000000000000000000000000008112 149.0
HFD2_k127_1095406_2 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 433.0
HFD2_k127_1095406_20 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000007016 105.0
HFD2_k127_1095406_21 nucleotide catabolic process K01081,K01119,K11751 - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 0.000000000000000000001733 104.0
HFD2_k127_1095406_22 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07658 - - 0.000000000000000000989 92.0
HFD2_k127_1095406_3 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 382.0
HFD2_k127_1095406_4 Ribonuclease HII K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 367.0
HFD2_k127_1095406_5 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07083,K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 348.0
HFD2_k127_1095406_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 330.0
HFD2_k127_1095406_7 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 308.0
HFD2_k127_1095406_8 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 293.0
HFD2_k127_1095406_9 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001065 283.0
HFD2_k127_1130909_0 Belongs to the ClpA ClpB family K03696 - - 0.0 1079.0
HFD2_k127_1130909_1 NAD(P) transhydrogenase beta subunit K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 478.0
HFD2_k127_1130909_10 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 300.0
HFD2_k127_1130909_11 Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 299.0
HFD2_k127_1130909_12 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004616 287.0
HFD2_k127_1130909_13 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000007185 269.0
HFD2_k127_1130909_14 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000003299 237.0
HFD2_k127_1130909_15 ABC-type transport system involved in lipoprotein release permease component K02004,K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - 0.000000000000000000000000000000000000000000000000000000000000000005208 240.0
HFD2_k127_1130909_16 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000985 192.0
HFD2_k127_1130909_17 FabA-like domain K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000003603 177.0
HFD2_k127_1130909_18 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000000000001004 168.0
HFD2_k127_1130909_19 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000005066 168.0
HFD2_k127_1130909_2 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 447.0
HFD2_k127_1130909_20 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 0.000000000000000000000000000000000000000003695 164.0
HFD2_k127_1130909_21 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000000000000002672 146.0
HFD2_k127_1130909_22 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000172 135.0
HFD2_k127_1130909_23 Recombinase - - - 0.000000000000000001298 88.0
HFD2_k127_1130909_24 TPM domain K06872 - - 0.00000000514 70.0
HFD2_k127_1130909_25 Tetratricopeptide repeat - - - 0.0000001482 64.0
HFD2_k127_1130909_26 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000002427 65.0
HFD2_k127_1130909_27 unfolded protein binding K06142 GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0019867,GO:0022417,GO:0022607,GO:0030288,GO:0030312,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0097367,GO:1901564 - 0.000001569 58.0
HFD2_k127_1130909_28 Outer membrane protein (OmpH-like) K06142 - - 0.00003463 54.0
HFD2_k127_1130909_29 Recombinase zinc beta ribbon domain - - - 0.00004649 48.0
HFD2_k127_1130909_3 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 464.0
HFD2_k127_1130909_30 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides - - - 0.0002085 54.0
HFD2_k127_1130909_4 Cleaves the N-terminal amino acid of tripeptides K01258 - 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 410.0
HFD2_k127_1130909_5 PFAM Alanine dehydrogenase PNT, C-terminal domain K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008447 371.0
HFD2_k127_1130909_6 Subtilase family K14645 GO:0005575,GO:0005576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 350.0
HFD2_k127_1130909_7 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 349.0
HFD2_k127_1130909_8 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 314.0
HFD2_k127_1130909_9 Protein of unknown function (DUF1009) K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 304.0
HFD2_k127_1231331_0 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 546.0
HFD2_k127_1231331_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 508.0
HFD2_k127_1231331_10 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000001216 195.0
HFD2_k127_1231331_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000004947 165.0
HFD2_k127_1231331_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000001045 160.0
HFD2_k127_1231331_13 23S rRNA-intervening sequence protein - - - 0.000000000000000000000000000000005302 132.0
HFD2_k127_1231331_14 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000001312 121.0
HFD2_k127_1231331_15 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 - 1.6.5.3 0.0000000000000000000000000001217 120.0
HFD2_k127_1231331_16 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000000000000000556 100.0
HFD2_k127_1231331_17 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000001321 104.0
HFD2_k127_1231331_18 transposition, DNA-mediated - - - 0.0000000000005001 74.0
HFD2_k127_1231331_19 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00002515 51.0
HFD2_k127_1231331_2 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007818 500.0
HFD2_k127_1231331_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 484.0
HFD2_k127_1231331_4 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 439.0
HFD2_k127_1231331_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008653 422.0
HFD2_k127_1231331_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 339.0
HFD2_k127_1231331_7 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004535 258.0
HFD2_k127_1231331_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000003774 243.0
HFD2_k127_1257915_0 transport - - - 2.239e-195 638.0
HFD2_k127_1257915_1 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 608.0
HFD2_k127_1257915_10 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001944 246.0
HFD2_k127_1257915_11 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000000000001178 246.0
HFD2_k127_1257915_12 PFAM Peptidase M20 - - - 0.0000000000000000000000000000000000000000000000000000001295 211.0
HFD2_k127_1257915_13 methyltransferase - - - 0.0000000000000000000000000000000000000000000001181 175.0
HFD2_k127_1257915_14 PFAM TM2 domain - - - 0.0000000000000000000000000000009128 126.0
HFD2_k127_1257915_15 Protein of unknown function (DUF2752) - - - 0.0000000000000000000000004 111.0
HFD2_k127_1257915_16 O-Antigen ligase K18814 - - 0.000000000000000000006166 107.0
HFD2_k127_1257915_17 - - - - 0.000000000000000228 85.0
HFD2_k127_1257915_18 Interferon-induced transmembrane protein - - - 0.0000000000000003878 81.0
HFD2_k127_1257915_19 Polysaccharide biosynthesis/export protein K01991 - - 0.00001188 57.0
HFD2_k127_1257915_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 483.0
HFD2_k127_1257915_3 transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 470.0
HFD2_k127_1257915_4 major pilin protein fima - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 429.0
HFD2_k127_1257915_5 RmlD substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 389.0
HFD2_k127_1257915_6 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 368.0
HFD2_k127_1257915_7 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 323.0
HFD2_k127_1257915_8 Highly conserved protein containing a thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 310.0
HFD2_k127_1257915_9 PFAM sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 302.0
HFD2_k127_1272166_0 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 618.0
HFD2_k127_1272166_1 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 467.0
HFD2_k127_1272166_10 - - - - 0.00000000000000000000000000000000000000000000000000001168 198.0
HFD2_k127_1272166_11 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000009389 165.0
HFD2_k127_1272166_12 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000316 134.0
HFD2_k127_1272166_13 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000001031 139.0
HFD2_k127_1272166_14 cheY-homologous receiver domain - - - 0.000000000000000000000000005856 114.0
HFD2_k127_1272166_15 Acyltransferase family - - - 0.0000000000000000000000197 114.0
HFD2_k127_1272166_16 Pfam:N_methyl_2 - - - 0.00000000000000001674 92.0
HFD2_k127_1272166_17 Pfam:N_methyl_2 - - - 0.00000000000000006177 87.0
HFD2_k127_1272166_18 Pfam:N_methyl_2 - - - 0.0000000000000002026 87.0
HFD2_k127_1272166_19 Methylase involved in ubiquinone menaquinone biosynthesis K03183 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 2.1.1.163,2.1.1.201 0.0000000000004513 79.0
HFD2_k127_1272166_2 sigma-54 factor interaction domain-containing protein K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 412.0
HFD2_k127_1272166_20 COG1943 Transposase and inactivated derivatives - - - 0.00006573 53.0
HFD2_k127_1272166_21 PFAM ATP-binding region, ATPase domain protein - - - 0.0003189 51.0
HFD2_k127_1272166_3 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 404.0
HFD2_k127_1272166_4 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 303.0
HFD2_k127_1272166_5 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 306.0
HFD2_k127_1272166_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009201 293.0
HFD2_k127_1272166_7 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
HFD2_k127_1272166_8 Pyridoxamine 5'-phosphate oxidase like - - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
HFD2_k127_1272166_9 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000625 217.0
HFD2_k127_133871_0 Carboxypeptidase regulatory-like domain - - - 0.0 1040.0
HFD2_k127_133871_1 Multicopper oxidase - - - 0.0 1038.0
HFD2_k127_133871_10 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000004062 196.0
HFD2_k127_133871_11 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000001356 186.0
HFD2_k127_133871_12 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000000000001205 186.0
HFD2_k127_133871_13 Bacterial regulatory proteins, tetR family K13770 - - 0.00000000000000000000000000000000000000000000003627 177.0
HFD2_k127_133871_14 YCII-related domain - - - 0.000000000000000000000000000000000000000003391 160.0
HFD2_k127_133871_15 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000004224 156.0
HFD2_k127_133871_16 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.000000000000000000000000001829 121.0
HFD2_k127_133871_17 transposition K07497 - - 0.0000000000000000006598 89.0
HFD2_k127_133871_18 Protein of unknown function (DUF2933) - - - 0.00000000000000002358 84.0
HFD2_k127_133871_2 PFAM TonB-dependent Receptor Plug K02014,K16089 - - 5.551e-213 683.0
HFD2_k127_133871_20 COG1918 Fe2 transport system protein A K04758 - - 0.00000000001775 69.0
HFD2_k127_133871_21 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.000000001992 60.0
HFD2_k127_133871_22 - - - - 0.000000007762 66.0
HFD2_k127_133871_3 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 557.0
HFD2_k127_133871_4 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 502.0
HFD2_k127_133871_5 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007462 507.0
HFD2_k127_133871_6 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 331.0
HFD2_k127_133871_7 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002236 283.0
HFD2_k127_133871_8 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000001499 244.0
HFD2_k127_133871_9 Transporter, small conductance mechanosensitive ion channel MscS family protein K03442 - - 0.000000000000000000000000000000000000000000000000000000000001022 222.0
HFD2_k127_1356351_0 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 0.0 1014.0
HFD2_k127_1356351_1 PFAM TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 558.0
HFD2_k127_1356351_2 Winged helix DNA-binding domain K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 499.0
HFD2_k127_1356351_3 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008949 467.0
HFD2_k127_1356351_4 Acetyltransferase (GNAT) domain K03825 - - 0.00000000000000000000000000000000000000000002449 168.0
HFD2_k127_1356351_5 Putative cyclase - - - 0.00000000003117 63.0
HFD2_k127_145957_0 Carboxypeptidase regulatory-like domain - - - 9.603e-223 730.0
HFD2_k127_145957_1 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 1.462e-218 689.0
HFD2_k127_145957_10 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 428.0
HFD2_k127_145957_11 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 414.0
HFD2_k127_145957_12 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 425.0
HFD2_k127_145957_13 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 406.0
HFD2_k127_145957_14 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 360.0
HFD2_k127_145957_15 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 354.0
HFD2_k127_145957_16 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000514 351.0
HFD2_k127_145957_17 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 349.0
HFD2_k127_145957_18 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 321.0
HFD2_k127_145957_19 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 318.0
HFD2_k127_145957_2 Dehydrogenase K02030,K03810 - - 8.365e-210 674.0
HFD2_k127_145957_20 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 306.0
HFD2_k127_145957_21 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009228 278.0
HFD2_k127_145957_23 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005023 264.0
HFD2_k127_145957_24 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002674 260.0
HFD2_k127_145957_25 Formyl transferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000007712 245.0
HFD2_k127_145957_26 Glycosyltransferase like family 2 K16870 - 2.4.1.289 0.00000000000000000000000000000000000000000000000000000000000000000004135 246.0
HFD2_k127_145957_27 methyltransferase K05928 - 2.1.1.95 0.000000000000000000000000000000000000000000000000000000000647 211.0
HFD2_k127_145957_28 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000007058 209.0
HFD2_k127_145957_29 domain protein K02238 - - 0.000000000000000000000000000000000000000000000000000000258 208.0
HFD2_k127_145957_3 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 562.0
HFD2_k127_145957_30 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000009037 210.0
HFD2_k127_145957_31 hydrolase of the alpha beta K07018 - - 0.00000000000000000000000000000000000000000000000003917 185.0
HFD2_k127_145957_32 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000004495 170.0
HFD2_k127_145957_33 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.000000000000000000000000000000000000000000003469 185.0
HFD2_k127_145957_34 RDD family - - - 0.000000000000000000000000000000000000000001524 167.0
HFD2_k127_145957_35 photosynthesis - - - 0.000000000000000000000000000000000000000001905 162.0
HFD2_k127_145957_36 chlorophyll binding - - - 0.000000000000000000000000000000000001698 151.0
HFD2_k127_145957_37 Aspartyl protease - - - 0.00000000000000000000000000000000028 140.0
HFD2_k127_145957_38 Belongs to the Fur family K09825 - - 0.0000000000000000000000000000002523 127.0
HFD2_k127_145957_39 Thioesterase superfamily K10806 - - 0.00000000000000000000000000001461 122.0
HFD2_k127_145957_4 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 548.0
HFD2_k127_145957_40 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000001716 117.0
HFD2_k127_145957_41 - - - - 0.000000000000000000000001032 107.0
HFD2_k127_145957_42 PFAM von Willebrand factor type A - - - 0.000000000000000000002302 107.0
HFD2_k127_145957_43 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000007325 99.0
HFD2_k127_145957_45 cheY-homologous receiver domain - - - 0.0000000000000000003965 94.0
HFD2_k127_145957_46 Polymer-forming cytoskeletal - - - 0.0000000000000000499 92.0
HFD2_k127_145957_47 Cytochrome c - - - 0.0000000000002097 75.0
HFD2_k127_145957_48 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000001261 70.0
HFD2_k127_145957_49 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000001358 67.0
HFD2_k127_145957_5 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 529.0
HFD2_k127_145957_50 Peptidase family M1 domain - - - 0.0005921 45.0
HFD2_k127_145957_6 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 491.0
HFD2_k127_145957_7 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 483.0
HFD2_k127_145957_8 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 473.0
HFD2_k127_145957_9 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 436.0
HFD2_k127_1467240_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 - 1.2.7.1 0.0 1700.0
HFD2_k127_1467240_1 Carboxypeptidase regulatory-like domain - - - 0.0 1159.0
HFD2_k127_1467240_10 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 4.264e-197 632.0
HFD2_k127_1467240_11 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 590.0
HFD2_k127_1467240_12 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 580.0
HFD2_k127_1467240_13 metallocarboxypeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 570.0
HFD2_k127_1467240_14 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 554.0
HFD2_k127_1467240_15 TIGRFAM magnesium chelatase, H subunit K03403 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 529.0
HFD2_k127_1467240_16 Domain of unknown function (DUF3479) K03403 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 528.0
HFD2_k127_1467240_17 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 471.0
HFD2_k127_1467240_18 ABC transporter K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 481.0
HFD2_k127_1467240_19 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 445.0
HFD2_k127_1467240_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1093.0
HFD2_k127_1467240_20 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 438.0
HFD2_k127_1467240_21 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 443.0
HFD2_k127_1467240_22 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 431.0
HFD2_k127_1467240_23 Putative glucoamylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 429.0
HFD2_k127_1467240_24 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 422.0
HFD2_k127_1467240_25 Cytochrome c554 and c-prime K03620 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005784 413.0
HFD2_k127_1467240_26 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 430.0
HFD2_k127_1467240_27 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 411.0
HFD2_k127_1467240_28 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 388.0
HFD2_k127_1467240_29 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 392.0
HFD2_k127_1467240_3 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0 1065.0
HFD2_k127_1467240_30 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 348.0
HFD2_k127_1467240_31 PFAM Binding-protein-dependent transport system inner membrane component K02033,K15581,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 342.0
HFD2_k127_1467240_32 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 306.0
HFD2_k127_1467240_33 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 300.0
HFD2_k127_1467240_34 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 299.0
HFD2_k127_1467240_35 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000007357 263.0
HFD2_k127_1467240_36 Di-haem oxidoreductase, putative peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001205 267.0
HFD2_k127_1467240_37 Periplasmic protein thiol K02199 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001366 249.0
HFD2_k127_1467240_38 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000000000000000000000002097 250.0
HFD2_k127_1467240_39 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.00000000000000000000000000000000000000000000000000000000000000000006442 237.0
HFD2_k127_1467240_4 Cytochrome c - - - 0.0 1038.0
HFD2_k127_1467240_40 Belongs to the P-Pant transferase superfamily K06133 - - 0.000000000000000000000000000000000000000000000000000000000000000001003 235.0
HFD2_k127_1467240_41 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000001097 249.0
HFD2_k127_1467240_42 Methyltransferase domain K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000004038 226.0
HFD2_k127_1467240_43 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000003104 224.0
HFD2_k127_1467240_44 deoxyhypusine monooxygenase activity K00627,K02160,K07402 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000006647 211.0
HFD2_k127_1467240_45 - - - - 0.000000000000000000000000000000000000000000000000000000002764 224.0
HFD2_k127_1467240_46 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000000000000000586 199.0
HFD2_k127_1467240_47 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000003044 205.0
HFD2_k127_1467240_48 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000379 204.0
HFD2_k127_1467240_49 Tetratricopeptide repeat K02200 - - 0.0000000000000000000000000000000000000000000000000000009463 207.0
HFD2_k127_1467240_5 Cytochrome c-type biogenesis protein CcmF K02198 - - 1.45e-304 945.0
HFD2_k127_1467240_50 response regulator receiver K02483,K07658 - - 0.000000000000000000000000000000000000000000000000000001799 199.0
HFD2_k127_1467240_51 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000003642 198.0
HFD2_k127_1467240_52 4Fe-4S binding domain K00395,K02572,K03616 - 1.8.99.2 0.00000000000000000000000000000000000000000000000002286 181.0
HFD2_k127_1467240_53 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.00000000000000000000000000000000000000000000000002789 182.0
HFD2_k127_1467240_55 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000001733 169.0
HFD2_k127_1467240_56 heme a metabolic process K02259,K03110 - - 0.00000000000000000000000000000000000000002001 165.0
HFD2_k127_1467240_57 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000001035 169.0
HFD2_k127_1467240_58 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000000013 151.0
HFD2_k127_1467240_59 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000221 129.0
HFD2_k127_1467240_6 hydrolase, family 3 K05349 - 3.2.1.21 1.543e-265 836.0
HFD2_k127_1467240_61 PFAM Transcription regulator MerR DNA binding K08365,K13638 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000416 119.0
HFD2_k127_1467240_62 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000003711 119.0
HFD2_k127_1467240_64 12 heme-binding sites - - - 0.00000000000000000004145 102.0
HFD2_k127_1467240_66 Evidence 4 Homologs of previously reported genes of K03975 - - 0.000000000000121 76.0
HFD2_k127_1467240_67 cell redox homeostasis K03671 - - 0.00000000009722 66.0
HFD2_k127_1467240_68 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.0000004544 54.0
HFD2_k127_1467240_7 CHASE3 domain - - - 3.413e-246 775.0
HFD2_k127_1467240_70 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.000002895 52.0
HFD2_k127_1467240_71 Class III cytochrome C family - - - 0.00001672 54.0
HFD2_k127_1467240_72 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.00002712 57.0
HFD2_k127_1467240_73 Tetratricopeptide TPR_2 repeat protein - - - 0.00004881 53.0
HFD2_k127_1467240_74 heat shock protein binding - - - 0.0004274 52.0
HFD2_k127_1467240_8 Protein of unknown function, DUF255 K06888 - - 8.586e-238 754.0
HFD2_k127_1467240_9 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 1.364e-202 644.0
HFD2_k127_1484463_0 Heat shock 70 kDa protein K04043 - - 1.96e-233 736.0
HFD2_k127_1484463_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 417.0
HFD2_k127_1484463_10 nucleotide metabolic process - - - 0.000000000000000000000000000000000000000000000000000002535 200.0
HFD2_k127_1484463_11 Conserved hypothetical protein 95 - - - 0.0000000000000000000000000000000000000000000001313 173.0
HFD2_k127_1484463_12 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000003893 178.0
HFD2_k127_1484463_13 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000006332 151.0
HFD2_k127_1484463_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.00000000000000000000000000006261 129.0
HFD2_k127_1484463_15 Pfam RibD C-terminal domain K00287 - 1.5.1.3 0.000000000000000000000000001658 113.0
HFD2_k127_1484463_16 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000004752 73.0
HFD2_k127_1484463_17 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000004433 51.0
HFD2_k127_1484463_3 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 307.0
HFD2_k127_1484463_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001221 261.0
HFD2_k127_1484463_5 HrcA protein C terminal domain K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002487 263.0
HFD2_k127_1484463_6 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001864 261.0
HFD2_k127_1484463_7 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000006838 265.0
HFD2_k127_1484463_8 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001039 227.0
HFD2_k127_1484463_9 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000008639 227.0
HFD2_k127_1519409_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372,K02567 - - 2.822e-285 894.0
HFD2_k127_1519409_1 nitrite transmembrane transporter activity K02575,K10850 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 396.0
HFD2_k127_1519409_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000001274 153.0
HFD2_k127_1519409_11 Lysine methyltransferase - - - 0.000000000000000000000000000000000000004379 156.0
HFD2_k127_1519409_12 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.0000000000000000000000000000000001004 141.0
HFD2_k127_1519409_13 Putative glucoamylase - - - 0.00000000565 57.0
HFD2_k127_1519409_2 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 334.0
HFD2_k127_1519409_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006317 312.0
HFD2_k127_1519409_4 response regulator, receiver K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 302.0
HFD2_k127_1519409_5 Alpha-aspartyl dipeptidase-like K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 299.0
HFD2_k127_1519409_6 nitrite transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 300.0
HFD2_k127_1519409_7 Domain of Unknown function (DUF542) K07322 - - 0.000000000000000000000000000000000000000000000000000000000000000000009213 241.0
HFD2_k127_1519409_9 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002372 232.0
HFD2_k127_1569174_0 Belongs to the glycosyl hydrolase 31 family K01811 - 3.2.1.177 0.0 1134.0
HFD2_k127_1569174_1 Fibronectin type III-like domain K05349 - 3.2.1.21 0.0 1030.0
HFD2_k127_1569174_10 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01706 - 4.2.1.40 1.72e-224 700.0
HFD2_k127_1569174_11 Amino acid permease - - - 3.554e-200 643.0
HFD2_k127_1569174_12 outer membrane efflux protein - - - 9.221e-196 622.0
HFD2_k127_1569174_13 Dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006617 616.0
HFD2_k127_1569174_14 xylose isomerase activity K01805 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 571.0
HFD2_k127_1569174_15 MviN-like protein K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 580.0
HFD2_k127_1569174_16 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000718 548.0
HFD2_k127_1569174_17 Peptidase inhibitor I9 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 547.0
HFD2_k127_1569174_18 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000922 503.0
HFD2_k127_1569174_19 PLD-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 512.0
HFD2_k127_1569174_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1025.0
HFD2_k127_1569174_20 Transport permease protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009194 482.0
HFD2_k127_1569174_21 PFAM secretion protein HlyD family protein K01993,K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 484.0
HFD2_k127_1569174_22 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 476.0
HFD2_k127_1569174_23 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 465.0
HFD2_k127_1569174_24 glucuronate isomerase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 460.0
HFD2_k127_1569174_25 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 460.0
HFD2_k127_1569174_26 protein histidine kinase activity K11383 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 455.0
HFD2_k127_1569174_27 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 440.0
HFD2_k127_1569174_28 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000864 473.0
HFD2_k127_1569174_29 PFAM ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 397.0
HFD2_k127_1569174_3 Belongs to the glycosyl hydrolase 2 family K01190 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899 3.2.1.23 2.405e-312 975.0
HFD2_k127_1569174_30 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003029 380.0
HFD2_k127_1569174_31 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 372.0
HFD2_k127_1569174_32 PFAM Glycosyl hydrolase family 10 K01181 - 3.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 364.0
HFD2_k127_1569174_33 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 316.0
HFD2_k127_1569174_34 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 308.0
HFD2_k127_1569174_35 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 297.0
HFD2_k127_1569174_36 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 289.0
HFD2_k127_1569174_37 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002986 270.0
HFD2_k127_1569174_38 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003733 278.0
HFD2_k127_1569174_39 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004986 263.0
HFD2_k127_1569174_4 Glycosyl hydrolase family 65, N-terminal domain K15923 - 3.2.1.51 6.539e-296 929.0
HFD2_k127_1569174_40 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000142 256.0
HFD2_k127_1569174_41 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000007329 229.0
HFD2_k127_1569174_42 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000000003318 215.0
HFD2_k127_1569174_43 phosphorelay signal transduction system K02490 - - 0.000000000000000000000000000000000000000000009145 173.0
HFD2_k127_1569174_44 SnoaL-like domain K06893 - - 0.0000000000000000000000000000000000000005363 158.0
HFD2_k127_1569174_45 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000221 135.0
HFD2_k127_1569174_46 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000002095 129.0
HFD2_k127_1569174_48 - - - - 0.0000000000000000000002703 104.0
HFD2_k127_1569174_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 1.344e-294 916.0
HFD2_k127_1569174_50 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000000000000000009359 108.0
HFD2_k127_1569174_51 - - - - 0.0000000000000000004943 88.0
HFD2_k127_1569174_52 amine dehydrogenase activity - - - 0.000000000000000231 91.0
HFD2_k127_1569174_53 Belongs to the glycosyl hydrolase 26 family - - - 0.000000000000001142 85.0
HFD2_k127_1569174_54 TPM domain K06872 - - 0.00000000000007856 80.0
HFD2_k127_1569174_55 Predicted membrane protein (DUF2306) - - - 0.00000000002416 67.0
HFD2_k127_1569174_56 PFAM TPR repeat-containing protein - - - 0.00000000004603 74.0
HFD2_k127_1569174_57 - - - - 0.0000000001058 63.0
HFD2_k127_1569174_59 Aldo/keto reductase family - - - 0.00001716 49.0
HFD2_k127_1569174_6 Carboxypeptidase regulatory-like domain - - - 4.062e-281 908.0
HFD2_k127_1569174_60 Predicted membrane protein (DUF2306) - - - 0.0003134 46.0
HFD2_k127_1569174_7 Belongs to the glycosyl hydrolase 67 family K01235 - 3.2.1.139 3.349e-266 838.0
HFD2_k127_1569174_8 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 2.321e-264 836.0
HFD2_k127_1569174_9 Belongs to the glycosyl hydrolase 2 family K01192 - 3.2.1.25 1.023e-260 828.0
HFD2_k127_1698730_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 525.0
HFD2_k127_1698730_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 330.0
HFD2_k127_1698730_2 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 308.0
HFD2_k127_1698730_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000109 53.0
HFD2_k127_1698730_4 Chaperone of endosialidase - - - 0.000005265 57.0
HFD2_k127_1744925_0 Glycosyltransferase 36 associated - - - 0.0 2407.0
HFD2_k127_1744925_1 serine threonine protein kinase K12132 - 2.7.11.1 7.313e-209 683.0
HFD2_k127_1744925_10 DnaJ molecular chaperone homology domain K19371 - - 0.000001614 61.0
HFD2_k127_1744925_12 Bacterial regulatory protein, Fis family - - - 0.00005575 51.0
HFD2_k127_1744925_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.783e-203 653.0
HFD2_k127_1744925_3 peptidase M20 K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 379.0
HFD2_k127_1744925_4 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 317.0
HFD2_k127_1744925_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000002474 220.0
HFD2_k127_1744925_6 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000004806 169.0
HFD2_k127_1744925_7 Histidine kinase - - - 0.00000000000000000000000000000005396 136.0
HFD2_k127_1744925_8 Belongs to the UPF0235 family K09131 - - 0.00000000000000001635 85.0
HFD2_k127_1744925_9 YGGT family K02221 - - 0.000000001158 67.0
HFD2_k127_180275_0 Carbamoyltransferase C-terminus K00612 - - 5.78e-262 820.0
HFD2_k127_180275_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 599.0
HFD2_k127_180275_10 maltose O-acetyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000001748 196.0
HFD2_k127_180275_11 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000005861 194.0
HFD2_k127_180275_12 O-Antigen ligase K02847 - - 0.000000000000000000000000000000000000000000003625 182.0
HFD2_k127_180275_13 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000002877 151.0
HFD2_k127_180275_14 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000007348 152.0
HFD2_k127_180275_15 Methyltransferase domain - - - 0.000000000000000000000000007535 122.0
HFD2_k127_180275_17 - - - - 0.0000000000002135 74.0
HFD2_k127_180275_18 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00002955 56.0
HFD2_k127_180275_19 Cytochrome c554 and c-prime - - - 0.0005851 52.0
HFD2_k127_180275_2 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 527.0
HFD2_k127_180275_3 Polysaccharide biosynthesis protein K17947 - 5.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 437.0
HFD2_k127_180275_4 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 412.0
HFD2_k127_180275_5 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007843 383.0
HFD2_k127_180275_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 297.0
HFD2_k127_180275_7 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002239 275.0
HFD2_k127_180275_8 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004261 275.0
HFD2_k127_180275_9 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000002004 206.0
HFD2_k127_1810516_0 transport - - - 0.0 1358.0
HFD2_k127_1810516_1 transport - - - 5e-323 1029.0
HFD2_k127_1810516_2 beta-lactamase - - - 1.659e-254 808.0
HFD2_k127_1810516_3 PFAM D-aminoacylase, C-terminal region K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006405 558.0
HFD2_k127_1810516_4 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000003478 199.0
HFD2_k127_1810516_5 COG0147 Anthranilate para-aminobenzoate synthases component I K01665 - 2.6.1.85 0.000000000000000000000000005344 113.0
HFD2_k127_1810516_6 TIGRFAM para-aminobenzoate synthase, subunit I K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000002369 57.0
HFD2_k127_1821880_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1341.0
HFD2_k127_1821880_1 ASPIC and UnbV - - - 7.754e-212 674.0
HFD2_k127_1821880_10 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 505.0
HFD2_k127_1821880_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 427.0
HFD2_k127_1821880_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 389.0
HFD2_k127_1821880_13 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 314.0
HFD2_k127_1821880_14 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 306.0
HFD2_k127_1821880_15 shikimate 3-dehydrogenase (NADP+) activity K00014,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 299.0
HFD2_k127_1821880_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 291.0
HFD2_k127_1821880_17 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006749 297.0
HFD2_k127_1821880_19 PFAM ROK family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001702 269.0
HFD2_k127_1821880_2 MFS/sugar transport protein K16211 - - 2.851e-210 664.0
HFD2_k127_1821880_20 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000001043 225.0
HFD2_k127_1821880_21 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000008012 224.0
HFD2_k127_1821880_22 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000001269 222.0
HFD2_k127_1821880_23 TPR repeat - - - 0.00000000000000000000000000000000000000000002478 181.0
HFD2_k127_1821880_24 YCII-related domain - - - 0.00000000000000000000000000000000000002712 146.0
HFD2_k127_1821880_25 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.0000000000000000000000000000000001947 140.0
HFD2_k127_1821880_26 - - - - 0.0000000000000000000000000001 122.0
HFD2_k127_1821880_27 Low molecular weight phosphotyrosine protein phosphatase K01104,K20201 - 3.1.3.48,3.9.1.2 0.0000000000000000000486 104.0
HFD2_k127_1821880_28 catechol 1,2-dioxygenase - - - 0.0000000000000009592 87.0
HFD2_k127_1821880_3 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 6.501e-206 662.0
HFD2_k127_1821880_30 DinB family - - - 0.000000000001611 74.0
HFD2_k127_1821880_31 Domain of unknown function (DUF4956) - - - 0.0000000003739 70.0
HFD2_k127_1821880_4 Cyclomaltodextrinase, N-terminal K21575 - 3.2.1.135 4.91e-204 653.0
HFD2_k127_1821880_5 Domain of unknown function (DUF5110) K01187 - 3.2.1.20 5.219e-201 652.0
HFD2_k127_1821880_6 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 579.0
HFD2_k127_1821880_7 Glucodextranase, domain N K01178 - 3.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 577.0
HFD2_k127_1821880_8 Cyclomaltodextrinase, N-terminal K21575 - 3.2.1.135 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 532.0
HFD2_k127_1821880_9 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 516.0
HFD2_k127_1832725_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1345.0
HFD2_k127_1832725_1 PLD-like domain K06131 - - 1.022e-218 689.0
HFD2_k127_1832725_10 Aldo keto reductase K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 516.0
HFD2_k127_1832725_11 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 539.0
HFD2_k127_1832725_12 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 486.0
HFD2_k127_1832725_13 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000893 467.0
HFD2_k127_1832725_14 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 469.0
HFD2_k127_1832725_15 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005821 459.0
HFD2_k127_1832725_16 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 456.0
HFD2_k127_1832725_17 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 448.0
HFD2_k127_1832725_18 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 482.0
HFD2_k127_1832725_19 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 404.0
HFD2_k127_1832725_2 Belongs to the glycosyl hydrolase 43 family - - - 4.535e-217 685.0
HFD2_k127_1832725_20 SAF K01685 - 4.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 395.0
HFD2_k127_1832725_21 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 362.0
HFD2_k127_1832725_22 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 363.0
HFD2_k127_1832725_23 glucosamine-6-phosphate deaminase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 344.0
HFD2_k127_1832725_24 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 383.0
HFD2_k127_1832725_25 Methyltransferase, chemotaxis proteins K00575,K13486 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 321.0
HFD2_k127_1832725_26 DNA alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 311.0
HFD2_k127_1832725_27 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005665 263.0
HFD2_k127_1832725_28 CheC inhibitor of MCP methylation K03410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001597 247.0
HFD2_k127_1832725_29 KWG Leptospira - - - 0.0000000000000000000000000000000000000000000000000000000000000000004397 243.0
HFD2_k127_1832725_3 PBS lyase HEAT-like repeat - - - 7.873e-213 682.0
HFD2_k127_1832725_30 phytanoyl-CoA dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000003856 240.0
HFD2_k127_1832725_31 FCD K05799 - - 0.00000000000000000000000000000000000000000000000000000000000000001131 233.0
HFD2_k127_1832725_32 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000000000000000000000000000000000000000000001482 220.0
HFD2_k127_1832725_34 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000003466 189.0
HFD2_k127_1832725_35 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000976 184.0
HFD2_k127_1832725_36 - - - - 0.000000000000000000000000000000000000000000001727 171.0
HFD2_k127_1832725_37 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000467 154.0
HFD2_k127_1832725_38 Response regulator receiver domain K03413 - - 0.000000000000000000000000000000000001375 141.0
HFD2_k127_1832725_39 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.000000000000000000000000000000004842 151.0
HFD2_k127_1832725_4 ABC-type antimicrobial peptide transport system, permease component - - - 4.452e-203 659.0
HFD2_k127_1832725_40 protein trimerization - - - 0.00000000000000000000000000000001083 132.0
HFD2_k127_1832725_41 Clostripain family - - - 0.0000000000000000000000000009116 130.0
HFD2_k127_1832725_42 PFAM BNR Asp-box repeat - - - 0.000000000000000000000005518 121.0
HFD2_k127_1832725_44 Protein conserved in bacteria - - - 0.00000000000005947 74.0
HFD2_k127_1832725_45 - - - - 0.00000001288 66.0
HFD2_k127_1832725_46 Patatin-like phospholipase K06900 - - 0.00000001548 62.0
HFD2_k127_1832725_47 Sporulation and spore germination - - - 0.0000001343 59.0
HFD2_k127_1832725_48 transmembrane transporter activity - - - 0.000001025 56.0
HFD2_k127_1832725_49 Esterase PHB depolymerase - - - 0.000002094 58.0
HFD2_k127_1832725_5 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 597.0
HFD2_k127_1832725_6 PFAM Major Facilitator Superfamily K08191 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 574.0
HFD2_k127_1832725_7 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 545.0
HFD2_k127_1832725_8 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 535.0
HFD2_k127_1832725_9 Glycosyl Hydrolase Family 88 K15532 - 3.2.1.172 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 520.0
HFD2_k127_1886900_0 Peptidase family M49 - - - 2.608e-211 670.0
HFD2_k127_1886900_1 Belongs to the HpcH HpaI aldolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 561.0
HFD2_k127_1886900_10 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000002956 203.0
HFD2_k127_1886900_11 UPF0314 protein - - - 0.0000000000000000000000000000000000005209 146.0
HFD2_k127_1886900_12 deoxyhypusine monooxygenase activity K05385 - - 0.000000000000000000000000007827 124.0
HFD2_k127_1886900_13 HEAT repeats - - - 0.0000000000000000000008168 108.0
HFD2_k127_1886900_14 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000001443 108.0
HFD2_k127_1886900_15 Thioredoxin-like - - - 0.000000000000000000004677 106.0
HFD2_k127_1886900_16 oxidoreductase activity K12511 - - 0.000000000001271 80.0
HFD2_k127_1886900_17 Glutathione peroxidase - - - 0.0000007013 59.0
HFD2_k127_1886900_18 Bacterial regulatory protein, Fis family K02584 - - 0.0007284 46.0
HFD2_k127_1886900_2 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 455.0
HFD2_k127_1886900_3 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 450.0
HFD2_k127_1886900_4 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 451.0
HFD2_k127_1886900_5 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 431.0
HFD2_k127_1886900_6 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 357.0
HFD2_k127_1886900_7 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 295.0
HFD2_k127_1886900_8 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007938 282.0
HFD2_k127_1886900_9 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000001523 204.0
HFD2_k127_1913654_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 616.0
HFD2_k127_1913654_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 554.0
HFD2_k127_1913654_10 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 426.0
HFD2_k127_1913654_11 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 424.0
HFD2_k127_1913654_12 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 404.0
HFD2_k127_1913654_13 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 361.0
HFD2_k127_1913654_14 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 338.0
HFD2_k127_1913654_15 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 337.0
HFD2_k127_1913654_16 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 288.0
HFD2_k127_1913654_17 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000002935 232.0
HFD2_k127_1913654_18 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000003127 233.0
HFD2_k127_1913654_19 Lysin motif - - - 0.00000000000000000000000000000000000000000000000000000000000000249 229.0
HFD2_k127_1913654_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 526.0
HFD2_k127_1913654_20 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000002441 219.0
HFD2_k127_1913654_21 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000001909 206.0
HFD2_k127_1913654_22 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000002203 196.0
HFD2_k127_1913654_23 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000008695 190.0
HFD2_k127_1913654_24 Alpha/beta hydrolase family K07020 - - 0.000000000000000000000000000000000000000000003168 172.0
HFD2_k127_1913654_25 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000005422 172.0
HFD2_k127_1913654_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000554 166.0
HFD2_k127_1913654_27 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000003618 166.0
HFD2_k127_1913654_28 S1/P1 Nuclease - - - 0.00000000000000000000000000000000000000114 160.0
HFD2_k127_1913654_29 OsmC-like protein K06889,K07397 - - 0.00000000000000000000000000000000000008057 147.0
HFD2_k127_1913654_3 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 505.0
HFD2_k127_1913654_30 binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000001052 146.0
HFD2_k127_1913654_31 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000001786 151.0
HFD2_k127_1913654_32 HAD-superfamily hydrolase subfamily IA, variant 3 K01091,K01838 - 3.1.3.18,5.4.2.6 0.000000000000000000000000000000003634 137.0
HFD2_k127_1913654_33 arsenate reductase (glutaredoxin) activity K00537 - 1.20.4.1 0.000000000000000000000000000003079 122.0
HFD2_k127_1913654_34 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000007239 124.0
HFD2_k127_1913654_35 Regulatory protein - - - 0.000000000000000000000000005366 115.0
HFD2_k127_1913654_36 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000558 112.0
HFD2_k127_1913654_37 protein with SCP PR1 domains - - - 0.000000000000000000001055 102.0
HFD2_k127_1913654_38 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000844 98.0
HFD2_k127_1913654_39 TIGRFAM TonB family K03832 - - 0.0000000000000000001657 100.0
HFD2_k127_1913654_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 498.0
HFD2_k127_1913654_40 histone H2A K63-linked ubiquitination - - - 0.0000000000002878 77.0
HFD2_k127_1913654_41 PFAM Tetratricopeptide repeat - - - 0.000000000003897 79.0
HFD2_k127_1913654_42 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000001334 74.0
HFD2_k127_1913654_43 - - - - 0.0000000001465 68.0
HFD2_k127_1913654_44 - - - - 0.0000000007431 61.0
HFD2_k127_1913654_46 Domain of unknown function (DUF4190) - - - 0.0000001956 59.0
HFD2_k127_1913654_47 - - - - 0.000001472 59.0
HFD2_k127_1913654_49 Heat shock chaperonin-binding motif. K09553 - - 0.0005338 52.0
HFD2_k127_1913654_5 Cys/Met metabolism PLP-dependent enzyme K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 490.0
HFD2_k127_1913654_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 497.0
HFD2_k127_1913654_7 Beta-Casp domain K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 456.0
HFD2_k127_1913654_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 432.0
HFD2_k127_1913654_9 Replicative DNA helicase K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 440.0
HFD2_k127_1946654_0 Belongs to the glycosyl hydrolase 13 family K21575 - 3.2.1.135 6.132e-290 906.0
HFD2_k127_1946654_1 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 591.0
HFD2_k127_1946654_10 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000006627 262.0
HFD2_k127_1946654_11 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000002179 230.0
HFD2_k127_1946654_12 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000006612 198.0
HFD2_k127_1946654_13 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000001261 188.0
HFD2_k127_1946654_14 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000006826 185.0
HFD2_k127_1946654_15 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0000000000000000000000000000000000001083 156.0
HFD2_k127_1946654_16 nuclease - - - 0.000000000000000000001194 108.0
HFD2_k127_1946654_18 Roadblock/LC7 domain - - - 0.00000000000006359 76.0
HFD2_k127_1946654_19 Flavin containing amine oxidoreductase - - - 0.00000000000006455 73.0
HFD2_k127_1946654_2 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 508.0
HFD2_k127_1946654_20 extracellular matrix structural constituent K02035 - - 0.00000000005054 76.0
HFD2_k127_1946654_21 TrwC relaxase - - - 0.0000000000824 64.0
HFD2_k127_1946654_23 PFAM Pilus assembly protein PilO K02664 - - 0.0000004293 59.0
HFD2_k127_1946654_24 Helix-turn-helix XRE-family like proteins - - - 0.00007287 49.0
HFD2_k127_1946654_25 PFAM Fimbrial assembly family protein K02663 - - 0.000456 50.0
HFD2_k127_1946654_3 PFAM UDP-galactopyranose mutase K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 507.0
HFD2_k127_1946654_4 N,N-dimethylaniline monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 457.0
HFD2_k127_1946654_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 413.0
HFD2_k127_1946654_6 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 319.0
HFD2_k127_1946654_7 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 317.0
HFD2_k127_1946654_8 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001049 314.0
HFD2_k127_1946654_9 maltose O-acetyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000009772 243.0
HFD2_k127_1952913_0 Dienelactone hydrolase family - - - 0.0 1012.0
HFD2_k127_1952913_1 Tetratricopeptide repeat - - - 1.675e-235 769.0
HFD2_k127_1952913_10 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 432.0
HFD2_k127_1952913_11 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 408.0
HFD2_k127_1952913_12 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 365.0
HFD2_k127_1952913_13 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 327.0
HFD2_k127_1952913_14 Chlorophyllase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 294.0
HFD2_k127_1952913_15 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002476 276.0
HFD2_k127_1952913_16 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001956 252.0
HFD2_k127_1952913_17 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001002 250.0
HFD2_k127_1952913_18 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001999 250.0
HFD2_k127_1952913_19 Protein conserved in bacteria K20274 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002823 273.0
HFD2_k127_1952913_2 Flavin-binding monooxygenase-like - - - 5.763e-231 724.0
HFD2_k127_1952913_20 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005973 243.0
HFD2_k127_1952913_21 NAD+ binding - - - 0.0000000000000000000000000000000000000000000000000000000000002712 228.0
HFD2_k127_1952913_22 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000003146 187.0
HFD2_k127_1952913_23 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000001877 187.0
HFD2_k127_1952913_24 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000000000000000000000004799 183.0
HFD2_k127_1952913_25 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000000001627 178.0
HFD2_k127_1952913_27 PFAM glycosyl transferase family 39 K14340 - - 0.00000000000000000000000000000000000000000000009771 189.0
HFD2_k127_1952913_28 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000001827 172.0
HFD2_k127_1952913_29 signal peptide processing K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000001212 170.0
HFD2_k127_1952913_3 Amidase K01426 - 3.5.1.4 3.482e-202 642.0
HFD2_k127_1952913_30 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000001761 160.0
HFD2_k127_1952913_31 - - - - 0.000000000000000000000000000000000000000004732 159.0
HFD2_k127_1952913_32 SnoaL-like domain - - - 0.000000000000000000000000000000000000000178 156.0
HFD2_k127_1952913_33 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000001354 156.0
HFD2_k127_1952913_34 self proteolysis - - - 0.0000000000000000000000000000000001004 141.0
HFD2_k127_1952913_35 - - - - 0.00000000000000000000000000001359 123.0
HFD2_k127_1952913_36 - - - - 0.00000000000000000000000000002475 121.0
HFD2_k127_1952913_37 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000003091 124.0
HFD2_k127_1952913_38 - - - - 0.00000000000000000000000008219 123.0
HFD2_k127_1952913_39 Glucose Sorbosone dehydrogenase - - - 0.00000000000000000000005025 117.0
HFD2_k127_1952913_4 A-macroglobulin complement component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 663.0
HFD2_k127_1952913_40 Acyltransferase family - - - 0.000000000000000000001178 108.0
HFD2_k127_1952913_42 - - - - 0.00000000000000000008532 93.0
HFD2_k127_1952913_43 TIGRFAM TonB K03832 - - 0.00000000000000003298 91.0
HFD2_k127_1952913_44 Preprotein translocase, YajC subunit K03210 - - 0.00000000000000041 83.0
HFD2_k127_1952913_46 Belongs to the UPF0102 family K07460 - - 0.000000000000003831 81.0
HFD2_k127_1952913_47 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.00000000001384 72.0
HFD2_k127_1952913_48 - - - - 0.0000000001528 64.0
HFD2_k127_1952913_49 23S rRNA-intervening sequence protein - - - 0.000000001453 63.0
HFD2_k127_1952913_5 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 555.0
HFD2_k127_1952913_50 - - - - 0.0000009396 57.0
HFD2_k127_1952913_51 oxidoreductase activity - - - 0.000009733 58.0
HFD2_k127_1952913_52 - - - - 0.00001215 53.0
HFD2_k127_1952913_6 PFAM DNA methylase N-4 N-6 domain protein K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 486.0
HFD2_k127_1952913_7 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 476.0
HFD2_k127_1952913_8 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 441.0
HFD2_k127_1952913_9 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007657 440.0
HFD2_k127_1955301_0 40-residue YVTN family beta-propeller repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 478.0
HFD2_k127_1955301_1 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 409.0
HFD2_k127_1955301_2 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 357.0
HFD2_k127_1955301_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000005533 222.0
HFD2_k127_1955301_4 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000004295 185.0
HFD2_k127_1955301_5 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000003164 145.0
HFD2_k127_1955301_6 DoxX-like family - - - 0.0000000000000000000000000000000003381 136.0
HFD2_k127_1955301_7 DinB family - - - 0.000000000000000000000001568 109.0
HFD2_k127_1955301_8 oxidoreductase activity - - - 0.00000000000000000009639 101.0
HFD2_k127_1984334_0 Ribosomal protein S1 K02945 - - 1.624e-206 659.0
HFD2_k127_1984334_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 592.0
HFD2_k127_1984334_10 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 305.0
HFD2_k127_1984334_11 ArgK protein K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 304.0
HFD2_k127_1984334_12 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002282 283.0
HFD2_k127_1984334_13 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008434 280.0
HFD2_k127_1984334_14 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001185 253.0
HFD2_k127_1984334_15 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000003219 240.0
HFD2_k127_1984334_16 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000007785 213.0
HFD2_k127_1984334_17 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000002444 215.0
HFD2_k127_1984334_18 metalloendopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000008591 210.0
HFD2_k127_1984334_19 PFAM histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000002444 198.0
HFD2_k127_1984334_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 512.0
HFD2_k127_1984334_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000001606 187.0
HFD2_k127_1984334_21 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000001309 169.0
HFD2_k127_1984334_22 Peptidase family M50 K06402 - - 0.000000000000000000000000000000000000000001818 164.0
HFD2_k127_1984334_23 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000002095 156.0
HFD2_k127_1984334_24 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000000001971 129.0
HFD2_k127_1984334_25 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000006367 114.0
HFD2_k127_1984334_26 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000001932 117.0
HFD2_k127_1984334_27 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000297 84.0
HFD2_k127_1984334_28 TIGRFAM VWFA-related Acidobacterial domain K07114 - - 0.0000000004609 71.0
HFD2_k127_1984334_29 M61 glycyl aminopeptidase - - - 0.000000002595 70.0
HFD2_k127_1984334_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 486.0
HFD2_k127_1984334_30 snoRNA binding - - - 0.00000001708 61.0
HFD2_k127_1984334_31 Sh3 type 3 domain protein - - - 0.00000003913 65.0
HFD2_k127_1984334_32 - - - - 0.0000002499 53.0
HFD2_k127_1984334_33 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.00002268 54.0
HFD2_k127_1984334_4 PFAM TonB-dependent Receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009687 420.0
HFD2_k127_1984334_5 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 395.0
HFD2_k127_1984334_6 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 394.0
HFD2_k127_1984334_7 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 357.0
HFD2_k127_1984334_8 7TM receptor with intracellular metal dependent phosphohydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 356.0
HFD2_k127_1984334_9 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 350.0
HFD2_k127_1985971_0 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 500.0
HFD2_k127_1985971_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 420.0
HFD2_k127_1985971_2 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 400.0
HFD2_k127_1985971_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004623 271.0
HFD2_k127_1985971_4 Putative glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003804 273.0
HFD2_k127_1985971_5 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000008946 243.0
HFD2_k127_1985971_6 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000007328 199.0
HFD2_k127_1985971_7 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000000000000000000000001784 186.0
HFD2_k127_1985971_8 PFAM HNH endonuclease - - - 0.00000000000000000000000000000006028 133.0
HFD2_k127_1985971_9 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000029 123.0
HFD2_k127_2029771_0 Belongs to the PEP-utilizing enzyme family K01006,K01007 - 2.7.9.1,2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007133 589.0
HFD2_k127_2029771_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 563.0
HFD2_k127_2029771_10 PFAM Pyridoxal-dependent decarboxylase conserved domain K01580,K01593,K13745 - 4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 301.0
HFD2_k127_2029771_11 oxidoreductase activity, acting on CH-OH group of donors K13237 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 289.0
HFD2_k127_2029771_12 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003222 278.0
HFD2_k127_2029771_13 with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001632 271.0
HFD2_k127_2029771_14 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000004725 257.0
HFD2_k127_2029771_15 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000006962 259.0
HFD2_k127_2029771_16 belongs to the PRA-CH family K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000002554 252.0
HFD2_k127_2029771_17 Histidine biosynthesis protein K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000812 238.0
HFD2_k127_2029771_18 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000003485 231.0
HFD2_k127_2029771_19 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000138 229.0
HFD2_k127_2029771_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 482.0
HFD2_k127_2029771_20 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000001567 216.0
HFD2_k127_2029771_21 HisG, C-terminal domain K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000005376 203.0
HFD2_k127_2029771_22 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000005472 205.0
HFD2_k127_2029771_23 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000001245 186.0
HFD2_k127_2029771_24 diguanylate cyclase - - - 0.0000000000000000000000000000000000003178 153.0
HFD2_k127_2029771_25 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000002766 145.0
HFD2_k127_2029771_26 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000002008 107.0
HFD2_k127_2029771_3 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 456.0
HFD2_k127_2029771_4 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 446.0
HFD2_k127_2029771_5 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 413.0
HFD2_k127_2029771_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 357.0
HFD2_k127_2029771_7 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 310.0
HFD2_k127_2029771_8 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 308.0
HFD2_k127_2029771_9 Inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 296.0
HFD2_k127_2063188_0 Dienelactone hydrolase family - - - 1.178e-319 992.0
HFD2_k127_2063188_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 2.519e-286 896.0
HFD2_k127_2063188_10 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 566.0
HFD2_k127_2063188_11 Cellulase (glycosyl hydrolase family 5) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 524.0
HFD2_k127_2063188_12 Pirin C-terminal cupin domain K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 432.0
HFD2_k127_2063188_13 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 436.0
HFD2_k127_2063188_14 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 445.0
HFD2_k127_2063188_15 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 418.0
HFD2_k127_2063188_16 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 421.0
HFD2_k127_2063188_17 ABC-type sugar transport system periplasmic component K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 409.0
HFD2_k127_2063188_18 Heparinase II/III N-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 397.0
HFD2_k127_2063188_19 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 374.0
HFD2_k127_2063188_2 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 8.097e-260 816.0
HFD2_k127_2063188_20 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 373.0
HFD2_k127_2063188_21 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 356.0
HFD2_k127_2063188_22 PFAM Glycosyl transferases group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008763 356.0
HFD2_k127_2063188_23 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 350.0
HFD2_k127_2063188_24 regulation of single-species biofilm formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 319.0
HFD2_k127_2063188_25 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 296.0
HFD2_k127_2063188_26 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001872 289.0
HFD2_k127_2063188_27 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003973 280.0
HFD2_k127_2063188_28 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000002519 214.0
HFD2_k127_2063188_29 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000002392 184.0
HFD2_k127_2063188_3 protein conserved in bacteria K09955 - - 1.525e-258 819.0
HFD2_k127_2063188_30 PFAM OsmC family protein K04063 - - 0.00000000000000000000000000000000000000000000002974 174.0
HFD2_k127_2063188_31 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000005164 168.0
HFD2_k127_2063188_32 helix_turn_helix multiple antibiotic resistance protein K15973 - - 0.0000000000000000000000000000000000000001452 155.0
HFD2_k127_2063188_33 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000001224 153.0
HFD2_k127_2063188_34 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000046 158.0
HFD2_k127_2063188_35 - - - - 0.00000000000000000000000000000000000001693 148.0
HFD2_k127_2063188_36 DinB superfamily K07552 - - 0.00000000000000000000000000000000000482 142.0
HFD2_k127_2063188_37 - - - - 0.00000000000000000000004527 104.0
HFD2_k127_2063188_38 Pilus assembly protein PilX K02673 - - 0.000000000000000002249 98.0
HFD2_k127_2063188_4 carboxylic acid catabolic process K01187 - 3.2.1.20 4.091e-256 806.0
HFD2_k127_2063188_41 Choline/ethanolamine kinase - - - 0.00008421 55.0
HFD2_k127_2063188_5 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 2.266e-244 774.0
HFD2_k127_2063188_6 Belongs to the glycosyl hydrolase 30 family K01201 - 3.2.1.45 4.361e-220 691.0
HFD2_k127_2063188_7 Belongs to the xylose isomerase family K01805 - 5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 611.0
HFD2_k127_2063188_8 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 606.0
HFD2_k127_2063188_9 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 597.0
HFD2_k127_2094737_0 Protein kinase domain K12132 - 2.7.11.1 6.016e-224 726.0
HFD2_k127_2094737_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 534.0
HFD2_k127_2094737_10 - - - - 0.0000000000000000006451 90.0
HFD2_k127_2094737_11 Protein of unknown function (DUF1176) - - - 0.00000003274 62.0
HFD2_k127_2094737_2 Rhs Family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008116 414.0
HFD2_k127_2094737_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 332.0
HFD2_k127_2094737_4 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000001031 223.0
HFD2_k127_2094737_5 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000000000000000000000000000000003078 234.0
HFD2_k127_2094737_6 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000415 212.0
HFD2_k127_2094737_7 oxidoreductase activity - - - 0.0000000000000000000000000000000000003696 161.0
HFD2_k127_2094737_8 serine-type endopeptidase activity K14645,K20276 - - 0.00000000000000000000001139 112.0
HFD2_k127_2094737_9 SMI1 / KNR4 family (SUKH-1) - - - 0.0000000000000000000006255 102.0
HFD2_k127_2130183_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006039 591.0
HFD2_k127_2130183_1 COG3621 Patatin K06900 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002786 395.0
HFD2_k127_2130183_10 DinB family - - - 0.0000000000000000000000000000000000000000000000000000102 196.0
HFD2_k127_2130183_11 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000006295 149.0
HFD2_k127_2130183_12 TIR domain - - - 0.00000000000000000000000000000000000002728 152.0
HFD2_k127_2130183_13 protein serine/threonine phosphatase activity - - - 0.00000000000000000000007643 108.0
HFD2_k127_2130183_14 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000001411 78.0
HFD2_k127_2130183_2 WD domain, G-beta repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007411 380.0
HFD2_k127_2130183_3 YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 377.0
HFD2_k127_2130183_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 327.0
HFD2_k127_2130183_5 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 306.0
HFD2_k127_2130183_6 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 297.0
HFD2_k127_2130183_7 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 299.0
HFD2_k127_2130183_8 protein homooligomerization - - - 0.000000000000000000000000000000000000000000000000000000000000002531 239.0
HFD2_k127_2130183_9 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity K16038 GO:0002682,GO:0002684,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000004013 214.0
HFD2_k127_2286759_0 glycoside hydrolase family 38 K01191 - 3.2.1.24 0.0 1425.0
HFD2_k127_2286759_1 transport - - - 0.0 1162.0
HFD2_k127_2286759_10 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 9.475e-195 618.0
HFD2_k127_2286759_100 Belongs to the ompA family - - - 0.00002951 55.0
HFD2_k127_2286759_11 ABC transporter K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 597.0
HFD2_k127_2286759_12 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000782 552.0
HFD2_k127_2286759_13 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005527 486.0
HFD2_k127_2286759_14 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K11177 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 499.0
HFD2_k127_2286759_15 PFAM Alcohol dehydrogenase GroES-like domain K00008,K00060 - 1.1.1.103,1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009945 478.0
HFD2_k127_2286759_16 6-phosphogluconolactonase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 524.0
HFD2_k127_2286759_17 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K10552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 460.0
HFD2_k127_2286759_18 cluster binding protein K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 467.0
HFD2_k127_2286759_19 Amidohydrolase family K05603 - 3.5.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 455.0
HFD2_k127_2286759_2 DNA Topoisomerase IV K02469 - 5.99.1.3 3.688e-304 954.0
HFD2_k127_2286759_20 Branched-chain amino acid transport system / permease component K10440,K10553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 436.0
HFD2_k127_2286759_21 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 422.0
HFD2_k127_2286759_22 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 426.0
HFD2_k127_2286759_23 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 455.0
HFD2_k127_2286759_24 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000972 409.0
HFD2_k127_2286759_25 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 395.0
HFD2_k127_2286759_26 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 399.0
HFD2_k127_2286759_27 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 391.0
HFD2_k127_2286759_28 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 388.0
HFD2_k127_2286759_29 D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 359.0
HFD2_k127_2286759_3 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 4.46e-301 940.0
HFD2_k127_2286759_30 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007309 371.0
HFD2_k127_2286759_31 enzyme involved in inositol metabolism K03337 - 5.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 353.0
HFD2_k127_2286759_32 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 361.0
HFD2_k127_2286759_33 PRMT5 arginine-N-methyltransferase K11434 - 2.1.1.319 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 338.0
HFD2_k127_2286759_34 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 340.0
HFD2_k127_2286759_35 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01707 - 4.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 326.0
HFD2_k127_2286759_36 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 356.0
HFD2_k127_2286759_37 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 312.0
HFD2_k127_2286759_38 Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 317.0
HFD2_k127_2286759_39 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007025 299.0
HFD2_k127_2286759_4 Urocanase Rossmann-like domain K01712 - 4.2.1.49 5.012e-271 842.0
HFD2_k127_2286759_40 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 297.0
HFD2_k127_2286759_41 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 295.0
HFD2_k127_2286759_42 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 310.0
HFD2_k127_2286759_43 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 292.0
HFD2_k127_2286759_44 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003506 282.0
HFD2_k127_2286759_45 PFAM Phage Tail Collar - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000439 273.0
HFD2_k127_2286759_46 HPr kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002847 278.0
HFD2_k127_2286759_47 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000064 268.0
HFD2_k127_2286759_48 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001224 264.0
HFD2_k127_2286759_49 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001208 271.0
HFD2_k127_2286759_5 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.576e-270 854.0
HFD2_k127_2286759_50 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001916 273.0
HFD2_k127_2286759_51 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000007792 260.0
HFD2_k127_2286759_52 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000002266 235.0
HFD2_k127_2286759_53 Predicted integral membrane protein (DUF2270) - - - 0.000000000000000000000000000000000000000000000000000000000000007038 234.0
HFD2_k127_2286759_54 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000101 250.0
HFD2_k127_2286759_55 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000000000003347 220.0
HFD2_k127_2286759_56 2Fe-2S -binding K13483 - - 0.000000000000000000000000000000000000000000000000000000002008 206.0
HFD2_k127_2286759_57 Serine threonine protein K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000002939 216.0
HFD2_k127_2286759_58 MoaE protein K21142 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000003189 201.0
HFD2_k127_2286759_59 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000005761 207.0
HFD2_k127_2286759_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.051e-229 718.0
HFD2_k127_2286759_60 Peptidase of plants and bacteria - - - 0.00000000000000000000000000000000000000000000000000001714 195.0
HFD2_k127_2286759_61 Transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000000002649 176.0
HFD2_k127_2286759_62 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000001446 184.0
HFD2_k127_2286759_63 Cation transport regulator - - - 0.00000000000000000000000000000000000000000000003355 175.0
HFD2_k127_2286759_64 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000003374 165.0
HFD2_k127_2286759_65 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000001204 164.0
HFD2_k127_2286759_66 PFAM Short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.0000000000000000000000000000000000000003019 154.0
HFD2_k127_2286759_67 ATP-dependent protease La (LON) substrate-binding domain K01338 - 3.4.21.53 0.000000000000000000000000000000000000001408 157.0
HFD2_k127_2286759_68 - - - - 0.000000000000000000000000000000000000001527 158.0
HFD2_k127_2286759_7 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 1.95e-207 659.0
HFD2_k127_2286759_70 DinB superfamily - - - 0.0000000000000000000000000000000000004438 146.0
HFD2_k127_2286759_71 N-acetyl-alpha-D-glucosaminyl L-malate synthase K00754 - - 0.000000000000000000000000000000007362 141.0
HFD2_k127_2286759_72 FR47-like protein - - - 0.0000000000000000000000000000001798 130.0
HFD2_k127_2286759_73 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000006962 131.0
HFD2_k127_2286759_74 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000004138 122.0
HFD2_k127_2286759_75 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000002377 123.0
HFD2_k127_2286759_76 4Fe-4S single cluster domain of Ferredoxin I - - - 0.000000000000000000000000009338 111.0
HFD2_k127_2286759_77 - - - - 0.000000000000000000000003176 103.0
HFD2_k127_2286759_78 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000004846 102.0
HFD2_k127_2286759_79 LUD domain K00782 - - 0.0000000000000000000005898 104.0
HFD2_k127_2286759_8 ATPases associated with a variety of cellular activities K06147 - - 1.066e-204 655.0
HFD2_k127_2286759_80 peptidase M15B and M15C DD-carboxypeptidase VanY - - - 0.0000000000000000000006729 107.0
HFD2_k127_2286759_81 - - - - 0.000000000000000000006757 105.0
HFD2_k127_2286759_82 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.00000000000000000008997 94.0
HFD2_k127_2286759_83 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000001033 93.0
HFD2_k127_2286759_84 Cupin 2, conserved barrel domain protein - - - 0.000000000000000006068 88.0
HFD2_k127_2286759_85 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000007597 86.0
HFD2_k127_2286759_86 Protein of unknown function (DUF1326) - - - 0.00000000000000003005 91.0
HFD2_k127_2286759_87 PFAM Bacterial pre-peptidase C-terminal domain - - - 0.0000000000000518 88.0
HFD2_k127_2286759_88 Transcription factor zinc-finger K09981 - - 0.000000000003026 70.0
HFD2_k127_2286759_89 - - - - 0.000000000003791 76.0
HFD2_k127_2286759_9 Aromatic amino acid lyase K01745 - 4.3.1.3 7.776e-201 637.0
HFD2_k127_2286759_90 - - - - 0.000000000003997 70.0
HFD2_k127_2286759_91 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000003355 74.0
HFD2_k127_2286759_92 CsbD-like - - - 0.0000000001154 64.0
HFD2_k127_2286759_93 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K07027 - - 0.0000000007859 70.0
HFD2_k127_2286759_94 Protein conserved in bacteria - - - 0.0000000009136 72.0
HFD2_k127_2286759_95 Endonuclease/Exonuclease/phosphatase family K07004 - - 0.00000000145 74.0
HFD2_k127_2286759_96 rhodanese-related sulfurtransferase - - - 0.000000002387 62.0
HFD2_k127_2286759_97 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07669,K07672 - - 0.00000000414 64.0
HFD2_k127_2286759_98 Resolvase, N terminal domain - - - 0.000008758 48.0
HFD2_k127_2286759_99 amine dehydrogenase activity K01179,K01406,K07004 - 3.2.1.4,3.4.24.40 0.00001628 60.0
HFD2_k127_2320841_0 Alpha-2-Macroglobulin K06894 - - 2e-304 990.0
HFD2_k127_2320841_1 Protein of unknown function (DUF1175) K09934 - - 0.000000000000000000000000000000000000000000000000001011 193.0
HFD2_k127_2320841_2 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000009043 186.0
HFD2_k127_2320841_3 Penicillin binding protein transpeptidase domain - - - 0.00000000000000000000000001285 127.0
HFD2_k127_2320841_4 - K05826 - - 0.0000000003672 62.0
HFD2_k127_2320841_5 domain protein K14475 - - 0.0000001248 61.0
HFD2_k127_2320841_6 - - - - 0.0006042 51.0
HFD2_k127_2354165_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1038.0
HFD2_k127_2354165_1 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 4.435e-270 841.0
HFD2_k127_2354165_10 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 359.0
HFD2_k127_2354165_11 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 350.0
HFD2_k127_2354165_12 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 291.0
HFD2_k127_2354165_13 Permease, YjgP YjgQ - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001352 287.0
HFD2_k127_2354165_14 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000004851 250.0
HFD2_k127_2354165_15 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000001647 252.0
HFD2_k127_2354165_16 Transcriptional regulator, LysR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004904 251.0
HFD2_k127_2354165_17 chromosome segregation K03497 - - 0.000000000000000000000000000000000000000000000000000000000003404 218.0
HFD2_k127_2354165_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000007203 204.0
HFD2_k127_2354165_19 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000004026 194.0
HFD2_k127_2354165_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.626e-203 643.0
HFD2_k127_2354165_20 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000002673 187.0
HFD2_k127_2354165_21 PFAM Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000001296 187.0
HFD2_k127_2354165_22 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000001029 180.0
HFD2_k127_2354165_23 - - - - 0.000000000000000000000000000000000000000000005492 171.0
HFD2_k127_2354165_24 ACT domain K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000009693 163.0
HFD2_k127_2354165_25 Involved in DNA repair and RecF pathway recombination K03474,K03584 GO:0008150,GO:0009314,GO:0009628,GO:0050896 2.6.99.2 0.000000000000000000000000000000000000006925 154.0
HFD2_k127_2354165_26 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000002276 142.0
HFD2_k127_2354165_27 adenosylhomocysteinase activity K01251 - 3.3.1.1 0.000000000000000000000000000000000003181 155.0
HFD2_k127_2354165_28 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000001034 141.0
HFD2_k127_2354165_29 diguanylate cyclase - - - 0.00000000000000000000000000000519 137.0
HFD2_k127_2354165_3 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.309e-202 642.0
HFD2_k127_2354165_30 Fibronectin type III domain - - - 0.000000000000000000000000001189 124.0
HFD2_k127_2354165_31 PQQ enzyme repeat - - - 0.00000000000000000000000798 115.0
HFD2_k127_2354165_32 - - - - 0.0000000000000000000001418 102.0
HFD2_k127_2354165_33 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000001206 89.0
HFD2_k127_2354165_34 Fibronectin type 3 domain - - - 0.00000000000001589 85.0
HFD2_k127_2354165_35 Tetratricopeptide repeat - - - 0.0000002324 62.0
HFD2_k127_2354165_36 Protein of unknown function (DUF465) - - - 0.00001884 48.0
HFD2_k127_2354165_4 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 8.026e-201 632.0
HFD2_k127_2354165_5 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 6.176e-199 636.0
HFD2_k127_2354165_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 543.0
HFD2_k127_2354165_7 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 543.0
HFD2_k127_2354165_8 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 473.0
HFD2_k127_2354165_9 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004456 411.0
HFD2_k127_2410306_0 cellulose binding - - - 0.0 1376.0
HFD2_k127_2410306_1 PFAM D-aminoacylase, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 538.0
HFD2_k127_2410306_10 Glyoxalase-like domain - - - 0.00000000000000000000000552 117.0
HFD2_k127_2410306_12 protein kinase activity - - - 0.00000002359 59.0
HFD2_k127_2410306_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000007958 57.0
HFD2_k127_2410306_14 - - - - 0.000006704 49.0
HFD2_k127_2410306_15 Domain of unknown function (DUF4412) - - - 0.0001019 55.0
HFD2_k127_2410306_2 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 497.0
HFD2_k127_2410306_3 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 296.0
HFD2_k127_2410306_4 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000001227 258.0
HFD2_k127_2410306_5 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000526 181.0
HFD2_k127_2410306_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000002585 173.0
HFD2_k127_2410306_7 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000757 164.0
HFD2_k127_2410306_8 - - - - 0.00000000000000000000000000000001623 147.0
HFD2_k127_2410306_9 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000002291 121.0
HFD2_k127_251167_0 Dipeptidyl peptidase IV (DPP IV) K01278 - 3.4.14.5 1.206e-290 911.0
HFD2_k127_251167_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 8.182e-254 797.0
HFD2_k127_251167_10 RmlD substrate binding domain K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 428.0
HFD2_k127_251167_11 Wzt C-terminal domain K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 406.0
HFD2_k127_251167_12 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 377.0
HFD2_k127_251167_13 PFAM Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 403.0
HFD2_k127_251167_14 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 321.0
HFD2_k127_251167_15 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 314.0
HFD2_k127_251167_16 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001354 288.0
HFD2_k127_251167_17 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004722 306.0
HFD2_k127_251167_18 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001454 261.0
HFD2_k127_251167_19 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000001044 251.0
HFD2_k127_251167_2 acyl-CoA dehydrogenase activity K09456 - - 7.543e-229 721.0
HFD2_k127_251167_20 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009247 254.0
HFD2_k127_251167_21 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000008532 248.0
HFD2_k127_251167_22 methyltransferase K18827 - 2.1.1.294,2.7.1.181 0.00000000000000000000000000000000000000000000000000000000000003669 233.0
HFD2_k127_251167_23 ABC-2 type transporter K01992,K09690,K09691,K09692 - - 0.0000000000000000000000000000000000000000000000000000000000064 216.0
HFD2_k127_251167_24 Phosphomethylpyrimidine kinase K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000003106 211.0
HFD2_k127_251167_25 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000001868 222.0
HFD2_k127_251167_26 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000009809 200.0
HFD2_k127_251167_27 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000001173 181.0
HFD2_k127_251167_28 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000003401 178.0
HFD2_k127_251167_29 BON domain - - - 0.000000000000000000000000000000000000000000004678 171.0
HFD2_k127_251167_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 2.773e-197 629.0
HFD2_k127_251167_30 HAD-superfamily hydrolase, subfamily IIB - - - 0.00000000000000000000000000000000000000001497 166.0
HFD2_k127_251167_31 - - - - 0.0000000000000000000000000000000000000001519 173.0
HFD2_k127_251167_32 CHRD domain - - - 0.0000000000000000000000000000000000001252 149.0
HFD2_k127_251167_33 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000003473 156.0
HFD2_k127_251167_34 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000001723 141.0
HFD2_k127_251167_35 acetylesterase activity - - - 0.000000000000000000000000000001996 136.0
HFD2_k127_251167_36 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000004895 123.0
HFD2_k127_251167_37 protein import - - - 0.0000000000000004813 93.0
HFD2_k127_251167_38 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000003194 71.0
HFD2_k127_251167_39 -O-antigen - - - 0.000004541 59.0
HFD2_k127_251167_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 550.0
HFD2_k127_251167_41 Ankyrin repeat - - - 0.00001328 57.0
HFD2_k127_251167_42 exo-alpha-(2->6)-sialidase activity K01406 - 3.4.24.40 0.00002476 56.0
HFD2_k127_251167_43 COG2931 RTX toxins and related Ca2 -binding - - - 0.000213 55.0
HFD2_k127_251167_44 pyrroloquinoline quinone binding - - - 0.0008466 53.0
HFD2_k127_251167_5 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 542.0
HFD2_k127_251167_6 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 507.0
HFD2_k127_251167_7 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 501.0
HFD2_k127_251167_8 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 486.0
HFD2_k127_251167_9 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 484.0
HFD2_k127_2703202_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 4.409e-247 773.0
HFD2_k127_2703202_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 297.0
HFD2_k127_2703202_2 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000004076 233.0
HFD2_k127_2703202_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000001058 95.0
HFD2_k127_2703202_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000008967 96.0
HFD2_k127_2703202_5 Belongs to the UPF0374 family K07586 - - 0.0000000000000006125 83.0
HFD2_k127_2703202_6 Retroviral aspartyl protease - - - 0.0003034 52.0
HFD2_k127_2769138_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1564.0
HFD2_k127_2769138_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1328.0
HFD2_k127_2769138_10 MacB-like periplasmic core domain - - - 5.185e-208 674.0
HFD2_k127_2769138_11 Glycine D-amino acid oxidase (deaminating) - - - 2.838e-203 644.0
HFD2_k127_2769138_12 efflux transmembrane transporter activity - - - 4.877e-201 653.0
HFD2_k127_2769138_13 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 599.0
HFD2_k127_2769138_14 Zinc-binding dehydrogenase K00008,K00148,K18369 - 1.1.1.14,1.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 576.0
HFD2_k127_2769138_15 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 554.0
HFD2_k127_2769138_16 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 465.0
HFD2_k127_2769138_17 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 475.0
HFD2_k127_2769138_18 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 464.0
HFD2_k127_2769138_19 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 449.0
HFD2_k127_2769138_2 cellulose binding - - - 0.0 1318.0
HFD2_k127_2769138_20 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 443.0
HFD2_k127_2769138_21 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 437.0
HFD2_k127_2769138_22 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 430.0
HFD2_k127_2769138_23 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 417.0
HFD2_k127_2769138_24 Arsenical pump-driving ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 413.0
HFD2_k127_2769138_25 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007547 386.0
HFD2_k127_2769138_26 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 402.0
HFD2_k127_2769138_27 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006267 388.0
HFD2_k127_2769138_28 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 391.0
HFD2_k127_2769138_29 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 380.0
HFD2_k127_2769138_3 Domain of unknown function (DUF5117) - - - 2.163e-297 934.0
HFD2_k127_2769138_30 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 375.0
HFD2_k127_2769138_31 Class II aldolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 369.0
HFD2_k127_2769138_32 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 350.0
HFD2_k127_2769138_33 CHASE3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 364.0
HFD2_k127_2769138_34 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 343.0
HFD2_k127_2769138_35 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 347.0
HFD2_k127_2769138_36 heat shock protein binding K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 336.0
HFD2_k127_2769138_37 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 353.0
HFD2_k127_2769138_38 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 325.0
HFD2_k127_2769138_39 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 325.0
HFD2_k127_2769138_4 MacB-like periplasmic core domain - - - 2.316e-238 760.0
HFD2_k127_2769138_40 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 325.0
HFD2_k127_2769138_41 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004564 305.0
HFD2_k127_2769138_42 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001346 278.0
HFD2_k127_2769138_43 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000002031 263.0
HFD2_k127_2769138_44 Actin K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006172 269.0
HFD2_k127_2769138_45 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000002849 257.0
HFD2_k127_2769138_46 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005562 267.0
HFD2_k127_2769138_47 pectinesterase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000001404 244.0
HFD2_k127_2769138_48 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000003198 225.0
HFD2_k127_2769138_49 PFAM Isochorismatase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000004838 203.0
HFD2_k127_2769138_5 glutamate--cysteine ligase - - - 1.676e-235 744.0
HFD2_k127_2769138_50 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000006065 209.0
HFD2_k127_2769138_51 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000001729 208.0
HFD2_k127_2769138_52 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000004525 205.0
HFD2_k127_2769138_53 - - - - 0.0000000000000000000000000000000000000000000000000009763 205.0
HFD2_k127_2769138_54 BON domain - - - 0.000000000000000000000000000000000000000002037 164.0
HFD2_k127_2769138_55 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000008003 142.0
HFD2_k127_2769138_56 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000008323 145.0
HFD2_k127_2769138_57 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000001439 155.0
HFD2_k127_2769138_58 - - - - 0.000000000000000000000000000000000003519 143.0
HFD2_k127_2769138_59 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000006181 151.0
HFD2_k127_2769138_6 Phosphate acyltransferases K01897 - 6.2.1.3 8.295e-231 743.0
HFD2_k127_2769138_60 Gas vesicle synthesis protein GvpL/GvpF - - - 0.00000000000000000000000000000000003324 147.0
HFD2_k127_2769138_61 Universal stress protein family - - - 0.0000000000000000000000000000000005506 142.0
HFD2_k127_2769138_62 Multicopper oxidase - - - 0.0000000000000000000000000000000006754 141.0
HFD2_k127_2769138_63 Transcriptional regulator - - - 0.00000000000000000000000000000006026 131.0
HFD2_k127_2769138_64 Universal stress protein family - - - 0.0000000000000000000000000000001221 129.0
HFD2_k127_2769138_65 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.000000000000000000000000000001422 123.0
HFD2_k127_2769138_66 Gas vesicle - - - 0.00000000000000000000000000002343 121.0
HFD2_k127_2769138_67 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.00000000000000000000000001823 113.0
HFD2_k127_2769138_68 Plasmid stabilization - - - 0.000000000000000000000003667 103.0
HFD2_k127_2769138_69 Gas vesicle synthesis protein GvpL/GvpF - - - 0.00000000000000000005153 100.0
HFD2_k127_2769138_7 efflux transmembrane transporter activity K02004 - - 2.351e-226 727.0
HFD2_k127_2769138_70 Sigma-70 region 2 K03088 - - 0.0000000000000000007096 93.0
HFD2_k127_2769138_71 - - - - 0.0000000000000003546 79.0
HFD2_k127_2769138_72 AMP binding - - - 0.000000000000000389 89.0
HFD2_k127_2769138_74 - - - - 0.000000000003851 67.0
HFD2_k127_2769138_75 gas vesicle protein - - - 0.00000000003915 67.0
HFD2_k127_2769138_76 Peptidoglycan-binding domain 1 protein - - - 0.00000000009605 72.0
HFD2_k127_2769138_77 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000005534 65.0
HFD2_k127_2769138_78 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000002097 57.0
HFD2_k127_2769138_79 - - - - 0.00000002801 60.0
HFD2_k127_2769138_8 FtsX-like permease family - - - 4.892e-214 692.0
HFD2_k127_2769138_80 Putative adhesin - - - 0.00000003242 65.0
HFD2_k127_2769138_81 Pfam:N_methyl_2 - - - 0.000003391 56.0
HFD2_k127_2769138_83 aminopeptidase activity - - - 0.0000344 48.0
HFD2_k127_2769138_9 Subtilase family - - - 6.899e-213 678.0
HFD2_k127_3013085_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 418.0
HFD2_k127_3013085_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001193 258.0
HFD2_k127_3013085_2 penicillin-binding protein - - - 0.000000000000000000000000000000000000000000000000000003175 211.0
HFD2_k127_3013085_3 extracellular polysaccharide biosynthetic process K13582 - - 0.00000000000000000000009266 110.0
HFD2_k127_3013085_4 Cytochrome c biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000005722 96.0
HFD2_k127_3013085_5 Periplasmic protein TonB links inner and outer membranes - - - 0.0006314 45.0
HFD2_k127_3076879_0 CHAT domain - - - 5.107e-303 966.0
HFD2_k127_3076879_1 Radical SAM - - - 8.852e-219 696.0
HFD2_k127_3076879_10 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000001634 225.0
HFD2_k127_3076879_11 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000004819 216.0
HFD2_k127_3076879_12 Domain of unknown function (DUF4157) K01227,K01448,K03791,K13277,K17733 - 3.2.1.96,3.5.1.28 0.0000000000000000000000000000000000000000000000000000001052 208.0
HFD2_k127_3076879_13 - - - - 0.000000006179 64.0
HFD2_k127_3076879_15 GAF domain K02482 - 2.7.13.3 0.0000143 51.0
HFD2_k127_3076879_16 Baseplate assembly protein - - - 0.00007093 47.0
HFD2_k127_3076879_17 DNA integration K14059 - - 0.0001746 44.0
HFD2_k127_3076879_2 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 543.0
HFD2_k127_3076879_3 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 387.0
HFD2_k127_3076879_4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K08641,K11206 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 312.0
HFD2_k127_3076879_5 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 306.0
HFD2_k127_3076879_6 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 289.0
HFD2_k127_3076879_7 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009936 288.0
HFD2_k127_3076879_8 PFAM Organic solvent tolerance protein K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005266 281.0
HFD2_k127_3076879_9 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000002319 258.0
HFD2_k127_3156679_0 Prolyl oligopeptidase family - - - 1.419e-265 836.0
HFD2_k127_3156679_1 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 613.0
HFD2_k127_3156679_10 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000226 252.0
HFD2_k127_3156679_11 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000003915 221.0
HFD2_k127_3156679_12 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000002461 199.0
HFD2_k127_3156679_13 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000000000001369 173.0
HFD2_k127_3156679_14 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000008948 177.0
HFD2_k127_3156679_15 Lysin motif - - - 0.000000000000000000000000000000000000000004253 160.0
HFD2_k127_3156679_16 PTS system fructose IIA component K02793,K02794,K02821 - 2.7.1.191,2.7.1.194 0.000000000000000000000000000000005637 132.0
HFD2_k127_3156679_17 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K09774 - - 0.000000000000000000000000000001023 141.0
HFD2_k127_3156679_18 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000000000001497 127.0
HFD2_k127_3156679_19 Belongs to the PEP-utilizing enzyme family K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000001624 127.0
HFD2_k127_3156679_2 cytochrome C peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 606.0
HFD2_k127_3156679_3 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 517.0
HFD2_k127_3156679_4 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 482.0
HFD2_k127_3156679_5 Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 435.0
HFD2_k127_3156679_6 RNA polymerase sigma-54 factor K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 355.0
HFD2_k127_3156679_7 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 314.0
HFD2_k127_3156679_8 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007948 274.0
HFD2_k127_3156679_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000004458 256.0
HFD2_k127_3282319_0 Multicopper oxidase - - - 0.0 1723.0
HFD2_k127_3282319_1 Amidohydrolase family K01464 - 3.5.2.2 7.579e-202 637.0
HFD2_k127_3282319_10 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 461.0
HFD2_k127_3282319_11 4Fe-4S dicluster domain K17723 - 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000952 436.0
HFD2_k127_3282319_12 dioxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 425.0
HFD2_k127_3282319_13 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006951 426.0
HFD2_k127_3282319_14 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 413.0
HFD2_k127_3282319_15 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 420.0
HFD2_k127_3282319_16 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 399.0
HFD2_k127_3282319_17 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 402.0
HFD2_k127_3282319_18 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 369.0
HFD2_k127_3282319_19 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 372.0
HFD2_k127_3282319_2 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 597.0
HFD2_k127_3282319_20 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 332.0
HFD2_k127_3282319_21 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 311.0
HFD2_k127_3282319_22 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000145 282.0
HFD2_k127_3282319_23 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000002819 228.0
HFD2_k127_3282319_24 SCO1/SenC K07152,K08976 - - 0.000000000000000000000000000000000000000000000000000000000001082 220.0
HFD2_k127_3282319_25 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000001453 207.0
HFD2_k127_3282319_26 SCO1/SenC K07152,K08976 - - 0.00000000000000000000000000000000000000000000000000006393 197.0
HFD2_k127_3282319_27 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000005455 182.0
HFD2_k127_3282319_28 Glycosyl transferase, family 2 K07011 - - 0.000000000000000000000000000000000000000000002687 176.0
HFD2_k127_3282319_29 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000001272 166.0
HFD2_k127_3282319_3 Beta-xylosidase K01198 - 3.2.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005974 575.0
HFD2_k127_3282319_31 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000005308 156.0
HFD2_k127_3282319_32 Protein of unknown function (DUF1440) K08996 - - 0.0000000000000000000000000000000707 131.0
HFD2_k127_3282319_33 PFAM Iron permease FTR1 - - - 0.00000000000000000007369 100.0
HFD2_k127_3282319_34 response regulator receiver K02481,K07714 - - 0.0000000000000006805 82.0
HFD2_k127_3282319_35 Protein of unknown function (DUF1176) - - - 0.00000000000001019 84.0
HFD2_k127_3282319_36 Protein conserved in bacteria K09914 - - 0.000000000009467 75.0
HFD2_k127_3282319_37 Protein of unknown function (DUF3108) - - - 0.0000004001 63.0
HFD2_k127_3282319_38 translation initiation factor activity K08086,K20541 - - 0.000001221 61.0
HFD2_k127_3282319_39 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000122 48.0
HFD2_k127_3282319_4 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 590.0
HFD2_k127_3282319_40 Trypsin-like peptidase domain K01173 - - 0.00001926 56.0
HFD2_k127_3282319_5 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 564.0
HFD2_k127_3282319_6 PFAM Peptidase S10, serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 553.0
HFD2_k127_3282319_7 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 556.0
HFD2_k127_3282319_8 Belongs to the aldehyde dehydrogenase family K22187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 505.0
HFD2_k127_3282319_9 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 473.0
HFD2_k127_328865_0 cellulose binding - - - 0.0 1562.0
HFD2_k127_328865_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1439.0
HFD2_k127_328865_10 Baseplate J-like protein - - - 2.449e-257 814.0
HFD2_k127_328865_11 Carboxypeptidase regulatory-like domain - - - 1.536e-248 802.0
HFD2_k127_328865_12 PFAM Amino acid permease K03294 - - 1.115e-224 711.0
HFD2_k127_328865_13 5TM C-terminal transporter carbon starvation CstA K06200 - - 7.777e-218 692.0
HFD2_k127_328865_14 ATPase family associated with various cellular activities (AAA) - - - 3.92e-212 680.0
HFD2_k127_328865_15 Phage tail sheath protein subtilisin-like domain - - - 1.874e-204 670.0
HFD2_k127_328865_16 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 611.0
HFD2_k127_328865_17 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 622.0
HFD2_k127_328865_18 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008294 570.0
HFD2_k127_328865_19 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 546.0
HFD2_k127_328865_2 Tricorn protease C1 domain K08676 - - 0.0 1336.0
HFD2_k127_328865_20 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008918 527.0
HFD2_k127_328865_21 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 504.0
HFD2_k127_328865_22 PFAM Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009617 469.0
HFD2_k127_328865_23 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009425 442.0
HFD2_k127_328865_24 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 438.0
HFD2_k127_328865_25 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 442.0
HFD2_k127_328865_26 Phage late control gene D protein (GPD) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 422.0
HFD2_k127_328865_27 protein and some similarities with VgrG protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 388.0
HFD2_k127_328865_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 392.0
HFD2_k127_328865_29 Belongs to the FGGY kinase family K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009448 388.0
HFD2_k127_328865_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1206.0
HFD2_k127_328865_30 amino acid K03294,K20265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 357.0
HFD2_k127_328865_31 PhoQ Sensor K07640 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 356.0
HFD2_k127_328865_32 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007707 342.0
HFD2_k127_328865_33 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 324.0
HFD2_k127_328865_34 Transcriptional regulatory protein, C terminal K07662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 311.0
HFD2_k127_328865_35 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000894 319.0
HFD2_k127_328865_36 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003202 299.0
HFD2_k127_328865_37 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003647 287.0
HFD2_k127_328865_38 Macrocin-O-methyltransferase (TylF) K05303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003481 276.0
HFD2_k127_328865_39 Flagellar Assembly Protein A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003983 277.0
HFD2_k127_328865_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0 1128.0
HFD2_k127_328865_40 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001483 269.0
HFD2_k127_328865_41 PFAM Phage integrase, N-terminal SAM-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005963 278.0
HFD2_k127_328865_42 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 255.0
HFD2_k127_328865_43 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001297 254.0
HFD2_k127_328865_44 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000002049 225.0
HFD2_k127_328865_45 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000002017 212.0
HFD2_k127_328865_46 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000001169 218.0
HFD2_k127_328865_47 - - - - 0.00000000000000000000000000000000000000000000000000000003547 208.0
HFD2_k127_328865_48 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000001058 211.0
HFD2_k127_328865_49 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000004794 188.0
HFD2_k127_328865_5 Flavin containing amine oxidoreductase - - - 4.187e-293 906.0
HFD2_k127_328865_50 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000000000000000000000000000001574 188.0
HFD2_k127_328865_51 GPW gp25 family protein K06903 - - 0.000000000000000000000000000000000000000000001911 167.0
HFD2_k127_328865_52 acetyltransferase - - - 0.00000000000000000000000000000000000000000005564 164.0
HFD2_k127_328865_53 - - - - 0.0000000000000000000000000000000000000000005508 179.0
HFD2_k127_328865_54 membrane - - - 0.000000000000000000000000000000000000000005354 157.0
HFD2_k127_328865_55 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.000000000000000000000000000000000000000005828 166.0
HFD2_k127_328865_56 HYR domain - - - 0.00000000000000000000000000000000000000003856 172.0
HFD2_k127_328865_57 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000002285 156.0
HFD2_k127_328865_58 - - - - 0.00000000000000000000000000000000004863 145.0
HFD2_k127_328865_59 PFAM Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000001125 145.0
HFD2_k127_328865_6 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 4.189e-275 860.0
HFD2_k127_328865_60 PFAM Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000001866 139.0
HFD2_k127_328865_61 - - - - 0.0000000000000000000000000000000002153 135.0
HFD2_k127_328865_62 deaminated base DNA N-glycosylase activity K21929 - 3.2.2.27 0.0000000000000000000000000000000005762 140.0
HFD2_k127_328865_63 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.00000000000000000000000000000000703 136.0
HFD2_k127_328865_64 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000002582 125.0
HFD2_k127_328865_65 Cephalosporin hydroxylase - - - 0.000000000000000000000000000001967 123.0
HFD2_k127_328865_66 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000000000000001836 120.0
HFD2_k127_328865_68 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000212 106.0
HFD2_k127_328865_69 Protein of unknown function (DUF445) - - - 0.000000000000000000001751 109.0
HFD2_k127_328865_7 Phage tail sheath C-terminal domain K06907 - - 4.623e-265 828.0
HFD2_k127_328865_70 Peptidase family M48 - - - 0.00000000000000000007037 101.0
HFD2_k127_328865_71 DinB superfamily - - - 0.0000000000000005996 84.0
HFD2_k127_328865_72 Universal stress protein - - - 0.00000000000001852 83.0
HFD2_k127_328865_73 Rhodanese Homology Domain - - - 0.00000000001861 68.0
HFD2_k127_328865_74 - - - - 0.00000000005817 74.0
HFD2_k127_328865_75 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000006317 70.0
HFD2_k127_328865_79 outer membrane autotransporter barrel domain protein - - - 0.000001754 57.0
HFD2_k127_328865_8 phage tail tape measure protein - - - 3.784e-259 835.0
HFD2_k127_328865_80 photosystem II stabilization K02237 - - 0.000003547 61.0
HFD2_k127_328865_81 membrane - - - 0.000009839 48.0
HFD2_k127_328865_82 - - - - 0.00002396 52.0
HFD2_k127_328865_83 HicA toxin of bacterial toxin-antitoxin, - - - 0.00002668 51.0
HFD2_k127_328865_84 - - - - 0.00002792 49.0
HFD2_k127_328865_85 Clp amino terminal domain, pathogenicity island component - - - 0.00005736 46.0
HFD2_k127_328865_86 Glycosyl hydrolase 101 beta sandwich domain - - - 0.0004828 53.0
HFD2_k127_328865_9 Phage tail protein (Tail_P2_I) - - - 6.351e-258 827.0
HFD2_k127_3355037_0 Multicopper oxidase - - - 0.0 1261.0
HFD2_k127_3355037_1 dna ligase - - - 2.803e-223 698.0
HFD2_k127_3355037_10 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008655 383.0
HFD2_k127_3355037_11 4Fe-4S binding domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 344.0
HFD2_k127_3355037_12 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 334.0
HFD2_k127_3355037_13 beta-fructofuranosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
HFD2_k127_3355037_14 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 317.0
HFD2_k127_3355037_15 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 - 3.1.3.77 0.0000000000000000000000000000000000000000000000000000000000000000000000004364 254.0
HFD2_k127_3355037_16 Beta-lactamase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000216 254.0
HFD2_k127_3355037_17 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate - - - 0.00000000000000000000000000000000000000000000000000000000000000000004139 249.0
HFD2_k127_3355037_18 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 - 1.13.11.53,1.13.11.54 0.0000000000000000000000000000000000000000000000000000000000000000001071 237.0
HFD2_k127_3355037_19 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 - 4.2.1.109 0.00000000000000000000000000000000000000000000000000000000000005954 219.0
HFD2_k127_3355037_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 619.0
HFD2_k127_3355037_20 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000000000000000000005614 194.0
HFD2_k127_3355037_21 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000003743 183.0
HFD2_k127_3355037_22 glycosyltransferase involved in LPS biosynthesis K07270 - - 0.00000000000000000000000000000000000000000001158 177.0
HFD2_k127_3355037_23 SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000526 169.0
HFD2_k127_3355037_24 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000002245 149.0
HFD2_k127_3355037_25 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000002596 153.0
HFD2_k127_3355037_26 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000003332 144.0
HFD2_k127_3355037_27 peptidyl-tyrosine sulfation K03217,K06872 - - 0.000000000000000000000000000000002116 142.0
HFD2_k127_3355037_28 Endoribonuclease L-PSP - - - 0.000000000000000000000000000002652 124.0
HFD2_k127_3355037_29 dioxygenase activity - - - 0.0000000000000000000000000002261 125.0
HFD2_k127_3355037_3 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006834 578.0
HFD2_k127_3355037_30 Glycosyltransferase like family 2 - - - 0.000000000000000000000000009975 121.0
HFD2_k127_3355037_31 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000002109 74.0
HFD2_k127_3355037_32 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.000000000008436 78.0
HFD2_k127_3355037_33 - - - - 0.00000000003637 69.0
HFD2_k127_3355037_34 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000109 69.0
HFD2_k127_3355037_35 2OG-Fe(II) oxygenase superfamily K15429 - 2.1.1.228 0.000000007937 66.0
HFD2_k127_3355037_36 Protein of unknown function (DUF433) - - - 0.000001669 53.0
HFD2_k127_3355037_37 Cation transport ATPase K17686 - 3.6.3.54 0.000008002 56.0
HFD2_k127_3355037_38 - - - - 0.0001077 50.0
HFD2_k127_3355037_39 Methyltransferase domain - - - 0.0001613 52.0
HFD2_k127_3355037_4 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 588.0
HFD2_k127_3355037_40 Glycosyltransferase family 92 - - - 0.0002347 52.0
HFD2_k127_3355037_5 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 568.0
HFD2_k127_3355037_6 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 506.0
HFD2_k127_3355037_7 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 446.0
HFD2_k127_3355037_8 H( )-stimulated, divalent metal cation uptake system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 395.0
HFD2_k127_3355037_9 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 387.0
HFD2_k127_344087_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1029.0
HFD2_k127_344087_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 8.798e-313 986.0
HFD2_k127_344087_10 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 492.0
HFD2_k127_344087_11 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 466.0
HFD2_k127_344087_12 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000756 406.0
HFD2_k127_344087_13 Domain of unknown function (DUF1972) K12996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 406.0
HFD2_k127_344087_14 virion core protein (lumpy skin disease virus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 403.0
HFD2_k127_344087_15 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K03797 - 3.1.11.6,3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 346.0
HFD2_k127_344087_16 ATPases associated with a variety of cellular activities K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 330.0
HFD2_k127_344087_17 two component, sigma54 specific, transcriptional regulator, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 332.0
HFD2_k127_344087_18 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001622 289.0
HFD2_k127_344087_19 ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002589 280.0
HFD2_k127_344087_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 6.524e-231 724.0
HFD2_k127_344087_20 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003745 278.0
HFD2_k127_344087_21 Glycosyl transferases group 1 K12994 - 2.4.1.349 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009752 279.0
HFD2_k127_344087_22 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001381 271.0
HFD2_k127_344087_23 DEAD DEAH box helicase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004953 263.0
HFD2_k127_344087_24 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000006992 263.0
HFD2_k127_344087_25 DSHCT - - - 0.0000000000000000000000000000000000000000000000000000000000000000007261 250.0
HFD2_k127_344087_26 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000412 230.0
HFD2_k127_344087_27 Protein tyrosine kinase K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000007802 246.0
HFD2_k127_344087_28 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000003649 234.0
HFD2_k127_344087_29 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000001813 204.0
HFD2_k127_344087_3 TonB dependent receptor - - - 1.185e-209 698.0
HFD2_k127_344087_30 transcriptional regulator - - - 0.00000000000000000000000000000000000000000001021 169.0
HFD2_k127_344087_31 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000001265 156.0
HFD2_k127_344087_32 FAD binding domain K21401 - 1.3.99.38 0.000000000000000000000000000000000000001896 162.0
HFD2_k127_344087_33 RNA recognition motif - - - 0.000000000000000000000000000000000009812 141.0
HFD2_k127_344087_34 Methyltransferase domain - - - 0.00000000000000000000000000000000001689 145.0
HFD2_k127_344087_35 - - - - 0.000000000000000000000000000000001784 144.0
HFD2_k127_344087_36 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000003773 132.0
HFD2_k127_344087_37 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000003918 130.0
HFD2_k127_344087_38 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000142 115.0
HFD2_k127_344087_39 nuclear chromosome segregation - - - 0.0000000000000000000000001382 121.0
HFD2_k127_344087_4 imidazolonepropionase activity K00466 - 1.13.12.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 540.0
HFD2_k127_344087_40 PFAM response regulator receiver K07657 - - 0.0000000000000000000003083 100.0
HFD2_k127_344087_41 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000001119 97.0
HFD2_k127_344087_42 Regulatory protein, FmdB - - - 0.0000000000000000000344 93.0
HFD2_k127_344087_43 KH domain K06960 - - 0.000000000000000173 81.0
HFD2_k127_344087_44 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000002089 76.0
HFD2_k127_344087_45 Tetratricopeptide repeat - - - 0.000000001431 70.0
HFD2_k127_344087_46 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000001655 66.0
HFD2_k127_344087_47 oxidoreductase activity - - - 0.00000003384 66.0
HFD2_k127_344087_48 general stress protein - - - 0.0000004926 57.0
HFD2_k127_344087_49 PFAM VanZ family protein - - - 0.00001036 48.0
HFD2_k127_344087_5 PFAM aminotransferase, class I K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 538.0
HFD2_k127_344087_50 Domain of unknown function (DUF4388) K12132 - 2.7.11.1 0.00004975 54.0
HFD2_k127_344087_6 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 495.0
HFD2_k127_344087_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 496.0
HFD2_k127_344087_8 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 487.0
HFD2_k127_344087_9 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 490.0
HFD2_k127_3513216_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0 2453.0
HFD2_k127_3513216_1 Peptidoglycan-binding domain 1 protein - - - 0.0 1842.0
HFD2_k127_3513216_10 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 612.0
HFD2_k127_3513216_100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K10697 - - 0.00000000000000000003705 108.0
HFD2_k127_3513216_101 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000006834 95.0
HFD2_k127_3513216_102 domain protein - - - 0.00000000000000002347 96.0
HFD2_k127_3513216_103 Protein of unknown function DUF84 - - - 0.0000000000005399 77.0
HFD2_k127_3513216_104 domain protein K14194 - - 0.000000000005806 79.0
HFD2_k127_3513216_105 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000003132 71.0
HFD2_k127_3513216_107 Tetratricopeptide repeat - - - 0.0000000006687 70.0
HFD2_k127_3513216_108 Belongs to the 'phage' integrase family - - - 0.00000000599 60.0
HFD2_k127_3513216_11 PFAM Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 599.0
HFD2_k127_3513216_110 phosphorelay signal transduction system - - - 0.00000003167 64.0
HFD2_k127_3513216_111 SMART Transport-associated and nodulation region K04065 - - 0.00000007006 64.0
HFD2_k127_3513216_115 self proteolysis - - - 0.00002351 56.0
HFD2_k127_3513216_116 - - - - 0.0005907 48.0
HFD2_k127_3513216_12 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 604.0
HFD2_k127_3513216_13 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 576.0
HFD2_k127_3513216_14 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 572.0
HFD2_k127_3513216_15 PFAM Pyridoxal-dependent decarboxylase conserved domain K01580,K01593,K13745 - 4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 568.0
HFD2_k127_3513216_16 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 556.0
HFD2_k127_3513216_17 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 576.0
HFD2_k127_3513216_18 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 553.0
HFD2_k127_3513216_19 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 549.0
HFD2_k127_3513216_2 Tricorn protease C1 domain K08676 - - 0.0 1273.0
HFD2_k127_3513216_20 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 547.0
HFD2_k127_3513216_21 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 511.0
HFD2_k127_3513216_22 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 490.0
HFD2_k127_3513216_23 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 506.0
HFD2_k127_3513216_24 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 479.0
HFD2_k127_3513216_25 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 470.0
HFD2_k127_3513216_26 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 468.0
HFD2_k127_3513216_27 - K00262 - 1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 465.0
HFD2_k127_3513216_28 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 460.0
HFD2_k127_3513216_29 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 455.0
HFD2_k127_3513216_3 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1246.0
HFD2_k127_3513216_30 Carboxymethylenebutenolidase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 451.0
HFD2_k127_3513216_31 Transporter-associated region K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 442.0
HFD2_k127_3513216_32 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 419.0
HFD2_k127_3513216_33 PD-(D/E)XK nuclease superfamily K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 443.0
HFD2_k127_3513216_34 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 413.0
HFD2_k127_3513216_35 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 410.0
HFD2_k127_3513216_36 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 390.0
HFD2_k127_3513216_37 PFAM TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 400.0
HFD2_k127_3513216_38 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 380.0
HFD2_k127_3513216_39 4Fe-4S single cluster domain of Ferredoxin I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 364.0
HFD2_k127_3513216_4 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1164.0
HFD2_k127_3513216_40 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000096 368.0
HFD2_k127_3513216_41 Aminotransferase class-V K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 358.0
HFD2_k127_3513216_42 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 359.0
HFD2_k127_3513216_43 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 357.0
HFD2_k127_3513216_44 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007434 357.0
HFD2_k127_3513216_45 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 334.0
HFD2_k127_3513216_46 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 296.0
HFD2_k127_3513216_47 Ferritin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 285.0
HFD2_k127_3513216_48 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001729 295.0
HFD2_k127_3513216_49 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002708 281.0
HFD2_k127_3513216_5 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 7.441e-285 885.0
HFD2_k127_3513216_50 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004704 285.0
HFD2_k127_3513216_51 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001865 286.0
HFD2_k127_3513216_52 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009337 278.0
HFD2_k127_3513216_53 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001386 269.0
HFD2_k127_3513216_54 Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 263.0
HFD2_k127_3513216_55 Actin K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001381 261.0
HFD2_k127_3513216_56 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001993 255.0
HFD2_k127_3513216_57 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000005543 239.0
HFD2_k127_3513216_58 TIGRFAM cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000001679 241.0
HFD2_k127_3513216_59 3'(2'),5'-bisphosphate nucleotidase activity K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000002616 239.0
HFD2_k127_3513216_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.68e-263 829.0
HFD2_k127_3513216_60 thymidine kinase activity K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000154 230.0
HFD2_k127_3513216_61 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.00000000000000000000000000000000000000000000000000000000000000007159 233.0
HFD2_k127_3513216_62 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000003359 234.0
HFD2_k127_3513216_63 beta-ketoacyl-acyl-carrier-protein synthase III activity K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000004864 234.0
HFD2_k127_3513216_64 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000001281 210.0
HFD2_k127_3513216_65 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000008837 214.0
HFD2_k127_3513216_66 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000663 203.0
HFD2_k127_3513216_67 The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000002434 226.0
HFD2_k127_3513216_68 Domain of unknown function (DUF1990) - - - 0.000000000000000000000000000000000000000000000000000000271 199.0
HFD2_k127_3513216_69 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000000000000005297 209.0
HFD2_k127_3513216_7 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00256 - 1.3.99.16 3.914e-252 800.0
HFD2_k127_3513216_70 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000001679 198.0
HFD2_k127_3513216_71 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000001054 198.0
HFD2_k127_3513216_72 iron ion homeostasis - - - 0.000000000000000000000000000000000000000000000000001258 207.0
HFD2_k127_3513216_74 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000000001167 175.0
HFD2_k127_3513216_75 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000006379 188.0
HFD2_k127_3513216_76 Plasmid stabilization system K19092 - - 0.00000000000000000000000000000000000000000001953 163.0
HFD2_k127_3513216_77 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000001017 172.0
HFD2_k127_3513216_78 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) K02491,K13533 - 2.7.13.3 0.000000000000000000000000000000000000000002677 181.0
HFD2_k127_3513216_79 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000003544 158.0
HFD2_k127_3513216_8 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 8.389e-203 648.0
HFD2_k127_3513216_80 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000001451 165.0
HFD2_k127_3513216_81 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000002599 152.0
HFD2_k127_3513216_82 acetyltransferase - - - 0.00000000000000000000000000000000000001167 149.0
HFD2_k127_3513216_83 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000001708 150.0
HFD2_k127_3513216_84 Radical SAM superfamily K22226 - - 0.00000000000000000000000000000000000152 151.0
HFD2_k127_3513216_85 Histidine kinase - - - 0.0000000000000000000000000000000001445 151.0
HFD2_k127_3513216_86 membrane - - - 0.0000000000000000000000000000000002704 134.0
HFD2_k127_3513216_87 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000001266 135.0
HFD2_k127_3513216_88 Redoxin - - - 0.000000000000000000000000000000002307 134.0
HFD2_k127_3513216_89 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000009255 138.0
HFD2_k127_3513216_9 PFAM NHL repeat - - - 1.77e-200 647.0
HFD2_k127_3513216_90 lipopolysaccharide heptosyltransferase K02841,K02843 - - 0.0000000000000000000000000000002601 136.0
HFD2_k127_3513216_91 two-component system, chemotaxis family, sensor kinase CheA with response regulator domain K03407 - 2.7.13.3 0.0000000000000000000000000000003024 135.0
HFD2_k127_3513216_92 - - - - 0.00000000000000000000000000007331 121.0
HFD2_k127_3513216_93 Rhomboid family K19225 - 3.4.21.105 0.0000000000000000000000000000966 130.0
HFD2_k127_3513216_94 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000000000141 110.0
HFD2_k127_3513216_95 Phosphoglycerate mutase family - - - 0.0000000000000000000000001356 115.0
HFD2_k127_3513216_96 cell redox homeostasis - - - 0.000000000000000000000003423 109.0
HFD2_k127_3513216_97 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000001277 100.0
HFD2_k127_3513216_98 von Willebrand factor, type A K07114 - - 0.000000000000000000002387 106.0
HFD2_k127_3513216_99 YbbR-like protein - - - 0.00000000000000000003642 102.0
HFD2_k127_359744_0 ThiC-associated domain K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 1.113e-305 949.0
HFD2_k127_359744_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 4.359e-295 922.0
HFD2_k127_359744_11 Permease family K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 387.0
HFD2_k127_359744_12 Associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 368.0
HFD2_k127_359744_13 PFAM Amidohydrolase 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 361.0
HFD2_k127_359744_14 Gluconolactonase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 357.0
HFD2_k127_359744_15 peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 376.0
HFD2_k127_359744_16 4Fe-4S double cluster binding domain K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007755 327.0
HFD2_k127_359744_17 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 321.0
HFD2_k127_359744_18 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006141 319.0
HFD2_k127_359744_19 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 307.0
HFD2_k127_359744_2 PFAM peptidase S9 prolyl oligopeptidase active site domain protein K01322,K01354 - 3.4.21.26,3.4.21.83 2.245e-261 823.0
HFD2_k127_359744_20 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009618 290.0
HFD2_k127_359744_21 oxidoreductase activity K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002994 282.0
HFD2_k127_359744_22 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001832 254.0
HFD2_k127_359744_23 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000007502 252.0
HFD2_k127_359744_24 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006339 248.0
HFD2_k127_359744_25 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002336 246.0
HFD2_k127_359744_26 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000002739 237.0
HFD2_k127_359744_27 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000008761 214.0
HFD2_k127_359744_28 2 iron, 2 sulfur cluster binding K03518,K07302 - 1.2.5.3,1.3.99.16 0.00000000000000000000000000000000000000000000000000000000001535 210.0
HFD2_k127_359744_29 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000225 207.0
HFD2_k127_359744_3 PFAM peptidase - - - 6.916e-195 623.0
HFD2_k127_359744_30 Thioredoxin reductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000705 183.0
HFD2_k127_359744_31 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000001158 163.0
HFD2_k127_359744_32 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000564 165.0
HFD2_k127_359744_33 Belongs to the allantoicase family K01477 - 3.5.3.4 0.0000000000000000000000000000000000000000005815 162.0
HFD2_k127_359744_34 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000007408 156.0
HFD2_k127_359744_35 phosphoprotein phosphatase activity K07313 - 3.1.3.16 0.000000000000000000000000000000000004197 147.0
HFD2_k127_359744_36 Transthyretin K07127 - 3.5.2.17 0.00000000000000000000000000000000946 132.0
HFD2_k127_359744_37 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000002929 129.0
HFD2_k127_359744_38 - - - - 0.00000000000000000000000000002342 130.0
HFD2_k127_359744_39 ThiS family K21029,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000005334 119.0
HFD2_k127_359744_4 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 556.0
HFD2_k127_359744_40 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000001493 108.0
HFD2_k127_359744_41 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.00000000000000000000007567 108.0
HFD2_k127_359744_42 Anti-sigma-K factor rskA - - - 0.0000000000000000000006314 106.0
HFD2_k127_359744_43 Domain of unknown function (DUF4350) - - - 0.000000000000006551 88.0
HFD2_k127_359744_44 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000005245 71.0
HFD2_k127_359744_46 pathogenesis - - - 0.00000000002971 75.0
HFD2_k127_359744_47 Domain of unknown function (DUF4129) - - - 0.00000000003596 74.0
HFD2_k127_359744_48 integral membrane protein - - - 0.0000000000393 74.0
HFD2_k127_359744_5 Amidohydrolase family K01466 - 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 525.0
HFD2_k127_359744_51 iron ion homeostasis - - - 0.00000006529 65.0
HFD2_k127_359744_52 - - - - 0.00000007265 61.0
HFD2_k127_359744_53 Domain of unknown function (DUF309) - - - 0.00000007353 62.0
HFD2_k127_359744_54 iron ion homeostasis - - - 0.0004786 53.0
HFD2_k127_359744_6 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 513.0
HFD2_k127_359744_7 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 490.0
HFD2_k127_359744_8 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 512.0
HFD2_k127_359744_9 Belongs to the allantoicase family K01477 - 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 463.0
HFD2_k127_3633105_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.222e-239 760.0
HFD2_k127_3633105_1 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 472.0
HFD2_k127_3633105_2 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000004123 172.0
HFD2_k127_3633105_3 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000002507 110.0
HFD2_k127_3633105_4 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000001453 95.0
HFD2_k127_3633105_5 Tetratricopeptide repeat - - - 0.000000000000000008515 93.0
HFD2_k127_3633105_6 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.000000000004009 78.0
HFD2_k127_3633105_7 Biopolymer transport protein K03559,K03560 - - 0.0000000009068 67.0
HFD2_k127_3640129_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 528.0
HFD2_k127_3640129_1 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 498.0
HFD2_k127_3640129_10 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 318.0
HFD2_k127_3640129_11 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 307.0
HFD2_k127_3640129_12 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 299.0
HFD2_k127_3640129_13 ZIP Zinc transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000000000000000001143 218.0
HFD2_k127_3640129_14 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000002088 212.0
HFD2_k127_3640129_15 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000003604 193.0
HFD2_k127_3640129_16 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000104 190.0
HFD2_k127_3640129_17 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000001079 184.0
HFD2_k127_3640129_18 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000000000000002868 180.0
HFD2_k127_3640129_19 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000000000008681 171.0
HFD2_k127_3640129_2 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 431.0
HFD2_k127_3640129_20 LemA family K03744 - - 0.00000000000000000000000000000000000000000002449 168.0
HFD2_k127_3640129_21 nucleotidyltransferase activity - - - 0.00000000000000000000000000000000000757 147.0
HFD2_k127_3640129_22 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000005659 139.0
HFD2_k127_3640129_23 BMC K04027 - - 0.0000000000000000000000000000000001892 133.0
HFD2_k127_3640129_24 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028,K08697 - - 0.0000000000000000000000000005549 115.0
HFD2_k127_3640129_25 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000001085 114.0
HFD2_k127_3640129_26 TPM domain K06872 - - 0.0000000000000000000000003003 116.0
HFD2_k127_3640129_27 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.000000000000000000000003548 104.0
HFD2_k127_3640129_28 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000002246 81.0
HFD2_k127_3640129_29 Virulence factor BrkB - - - 0.00000000000006154 82.0
HFD2_k127_3640129_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 409.0
HFD2_k127_3640129_30 Ethanolamine utilisation protein EutN/carboxysome K04028 - - 0.000000004682 61.0
HFD2_k127_3640129_31 Cell division protein FtsQ K03589 - - 0.00003067 55.0
HFD2_k127_3640129_32 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.00054 51.0
HFD2_k127_3640129_33 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0009642 46.0
HFD2_k127_3640129_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 394.0
HFD2_k127_3640129_5 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 366.0
HFD2_k127_3640129_6 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 357.0
HFD2_k127_3640129_7 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 314.0
HFD2_k127_3640129_8 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
HFD2_k127_3640129_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 320.0
HFD2_k127_3674789_0 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 2.791e-299 927.0
HFD2_k127_3674789_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 9.179e-243 767.0
HFD2_k127_3674789_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007674 558.0
HFD2_k127_3674789_3 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 470.0
HFD2_k127_3674789_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 288.0
HFD2_k127_3674789_5 - - - - 0.00000000000000000000000000000000000000000000000000000005755 201.0
HFD2_k127_3674789_6 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000000000000000000006929 204.0
HFD2_k127_3674789_7 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000000000007716 189.0
HFD2_k127_3674789_8 YwiC-like protein - - - 0.00000000000000000000000000000000000000000003756 170.0
HFD2_k127_3674789_9 Cupin domain protein - - - 0.000000000000000000000000001232 117.0
HFD2_k127_3697295_0 - K17285 - - 0.0 1257.0
HFD2_k127_3697295_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.502e-270 859.0
HFD2_k127_3697295_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 528.0
HFD2_k127_3697295_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000001111 95.0
HFD2_k127_3697295_4 PD-(D/E)XK nuclease superfamily - - - 0.000000000009522 69.0
HFD2_k127_3706528_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 348.0
HFD2_k127_3706528_1 CAAX protease self-immunity K07052 - - 0.00006085 53.0
HFD2_k127_3917695_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 4.647e-227 719.0
HFD2_k127_3917695_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 559.0
HFD2_k127_3917695_10 ABC-type molybdate transport system, permease component K02018 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000003443 223.0
HFD2_k127_3917695_11 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000001387 172.0
HFD2_k127_3917695_12 outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000001812 146.0
HFD2_k127_3917695_13 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000003282 137.0
HFD2_k127_3917695_2 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 497.0
HFD2_k127_3917695_3 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 495.0
HFD2_k127_3917695_4 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 478.0
HFD2_k127_3917695_5 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 398.0
HFD2_k127_3917695_6 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 385.0
HFD2_k127_3917695_7 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 299.0
HFD2_k127_3917695_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 287.0
HFD2_k127_3917695_9 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000006148 263.0
HFD2_k127_3938035_0 Vitamin B12 dependent methionine synthase, activation domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1365.0
HFD2_k127_3938035_1 Male sterility protein K01897 - 6.2.1.3 0.0 1305.0
HFD2_k127_3938035_10 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001328 248.0
HFD2_k127_3938035_11 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000004113 245.0
HFD2_k127_3938035_12 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000008016 226.0
HFD2_k127_3938035_13 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000008586 213.0
HFD2_k127_3938035_14 Domain of unknown function (DUF4162) K01990 - - 0.00000000000000000000000000000000000000000000000000001173 209.0
HFD2_k127_3938035_15 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000000000000000000000000000003895 181.0
HFD2_k127_3938035_16 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000001894 172.0
HFD2_k127_3938035_17 Transport permease protein K01992 - - 0.00000000000000000000000000000000000009616 153.0
HFD2_k127_3938035_18 peptidoglycan catabolic process - - - 0.000000000000000000000000000007728 126.0
HFD2_k127_3938035_19 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000002562 124.0
HFD2_k127_3938035_2 Domain of unknown function (DUF2088) - - - 7.893e-225 709.0
HFD2_k127_3938035_20 - - - - 0.0000000000000000001413 95.0
HFD2_k127_3938035_21 methyltransferase - - - 0.000000000000000464 88.0
HFD2_k127_3938035_22 Belongs to the peptidase M16 family - - - 0.00000000000001426 87.0
HFD2_k127_3938035_23 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000006405 72.0
HFD2_k127_3938035_24 Peptidase family S41 - - - 0.000004628 60.0
HFD2_k127_3938035_3 Tetratricopeptide repeat - - - 1.821e-196 629.0
HFD2_k127_3938035_4 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 353.0
HFD2_k127_3938035_5 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 343.0
HFD2_k127_3938035_6 cystathionine gamma-synthase activity K01739,K01758,K01760,K01761 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 325.0
HFD2_k127_3938035_7 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 318.0
HFD2_k127_3938035_8 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 309.0
HFD2_k127_3938035_9 epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 307.0
HFD2_k127_3951554_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 2.412e-196 641.0
HFD2_k127_3951554_10 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000001171 226.0
HFD2_k127_3951554_11 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000008103 229.0
HFD2_k127_3951554_12 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000005895 205.0
HFD2_k127_3951554_13 Enoyl-(Acyl carrier protein) reductase K00034,K03366 - 1.1.1.304,1.1.1.47,1.1.1.76 0.000000000000000000000000000000000000000000000000000002995 199.0
HFD2_k127_3951554_14 Abc transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000005562 200.0
HFD2_k127_3951554_15 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000001887 185.0
HFD2_k127_3951554_16 Radical SAM K22227 - - 0.00000000000000000000000000000000000001611 158.0
HFD2_k127_3951554_17 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000128 149.0
HFD2_k127_3951554_18 2OG-Fe(II) oxygenase superfamily K07336,K07394 - - 0.00000000000000000000000000000000843 134.0
HFD2_k127_3951554_19 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000009824 124.0
HFD2_k127_3951554_2 UDP binding domain K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 569.0
HFD2_k127_3951554_21 Membrane - - - 0.0002185 50.0
HFD2_k127_3951554_3 Carbamoyltransferase C-terminus K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006016 454.0
HFD2_k127_3951554_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 430.0
HFD2_k127_3951554_5 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 404.0
HFD2_k127_3951554_6 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 400.0
HFD2_k127_3951554_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 374.0
HFD2_k127_3951554_8 NAD(P)H-binding K01784,K02473 - 5.1.3.2,5.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 360.0
HFD2_k127_3951554_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 330.0
HFD2_k127_4029927_0 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 492.0
HFD2_k127_4029927_1 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 427.0
HFD2_k127_4029927_10 - - - - 0.0001199 44.0
HFD2_k127_4029927_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 418.0
HFD2_k127_4029927_3 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 364.0
HFD2_k127_4029927_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000291 213.0
HFD2_k127_4029927_5 Domain of unknown function (DUF5011) - - - 0.000000000000000000000000000000000000000000000000001195 209.0
HFD2_k127_4029927_6 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000002207 181.0
HFD2_k127_4029927_7 Parallel beta-helix repeats - - - 0.00000000000000000001275 92.0
HFD2_k127_4029927_9 PFAM Endonuclease Exonuclease phosphatase K07004 - - 0.0000000000000001021 95.0
HFD2_k127_4042265_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.293e-211 666.0
HFD2_k127_4042265_1 PFAM TonB-dependent Receptor Plug - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 625.0
HFD2_k127_4042265_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002263 227.0
HFD2_k127_4042265_11 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000007061 201.0
HFD2_k127_4042265_12 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000000000000000005894 194.0
HFD2_k127_4042265_13 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000000155 183.0
HFD2_k127_4042265_14 Low affinity iron permease - - - 0.0000000000000000000000000000000000000000000005242 173.0
HFD2_k127_4042265_15 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000004534 167.0
HFD2_k127_4042265_16 Related to alanyl-tRNA synthetase HxxxH domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000001548 155.0
HFD2_k127_4042265_17 BMC - - - 0.0000000000000000000000000000000000002872 146.0
HFD2_k127_4042265_18 - - - - 0.000000000000000000000000000000000001439 141.0
HFD2_k127_4042265_19 Carbon dioxide concentrating mechanism carboxysome shell protein - - - 0.00000000000000000000000000002471 119.0
HFD2_k127_4042265_2 UPF0210 protein K09157 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 561.0
HFD2_k127_4042265_20 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 - - 0.0000000000000000000000000464 112.0
HFD2_k127_4042265_21 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000005618 108.0
HFD2_k127_4042265_22 Belongs to the UPF0237 family K07166 - - 0.0000000000000000005795 92.0
HFD2_k127_4042265_23 WD40 domain protein beta Propeller - - - 0.000000000000001072 92.0
HFD2_k127_4042265_24 Helix-turn-helix domain K15539 - - 0.0000000000001259 78.0
HFD2_k127_4042265_3 AAA ATPase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 524.0
HFD2_k127_4042265_4 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 455.0
HFD2_k127_4042265_5 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 404.0
HFD2_k127_4042265_6 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 400.0
HFD2_k127_4042265_7 Peptidase M61 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003952 332.0
HFD2_k127_4042265_8 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006195 267.0
HFD2_k127_4042265_9 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000002731 241.0
HFD2_k127_4117004_0 His Kinase A (phosphoacceptor) domain - - - 3.038e-209 679.0
HFD2_k127_4117004_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 509.0
HFD2_k127_4117004_10 Periplasmic component of the Tol biopolymer transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 333.0
HFD2_k127_4117004_11 enterobactin catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007195 310.0
HFD2_k127_4117004_12 regulation of methylation-dependent chromatin silencing K07454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 287.0
HFD2_k127_4117004_13 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001118 235.0
HFD2_k127_4117004_15 Glutamine cyclotransferase K00683 - 2.3.2.5 0.0000000000000000000000000000000000000000000286 169.0
HFD2_k127_4117004_16 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000005361 140.0
HFD2_k127_4117004_17 heat shock protein DnaJ K05516 - - 0.000000000000000000000000000000001052 137.0
HFD2_k127_4117004_18 Putative peptidoglycan binding domain - - - 0.00000000000000000000000000000006412 134.0
HFD2_k127_4117004_19 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000209 130.0
HFD2_k127_4117004_2 Sulfatase K01133 - 3.1.6.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 467.0
HFD2_k127_4117004_21 - - - - 0.000000000000000000000316 104.0
HFD2_k127_4117004_22 - - - - 0.000000000000000000002607 100.0
HFD2_k127_4117004_23 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000005934 85.0
HFD2_k127_4117004_25 - - - - 0.0000001009 59.0
HFD2_k127_4117004_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006813 459.0
HFD2_k127_4117004_4 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 455.0
HFD2_k127_4117004_5 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 397.0
HFD2_k127_4117004_6 PFAM beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 396.0
HFD2_k127_4117004_7 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 344.0
HFD2_k127_4117004_8 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 329.0
HFD2_k127_4117004_9 Hydrolase Family 16 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 324.0
HFD2_k127_4211679_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1399.0
HFD2_k127_4211679_1 Radical SAM - - - 1e-323 1003.0
HFD2_k127_4211679_10 efflux transmembrane transporter activity K02004 - - 1.349e-199 651.0
HFD2_k127_4211679_11 efflux transmembrane transporter activity K02004 - - 2.865e-197 642.0
HFD2_k127_4211679_12 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000659 642.0
HFD2_k127_4211679_13 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 603.0
HFD2_k127_4211679_14 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 602.0
HFD2_k127_4211679_15 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 601.0
HFD2_k127_4211679_16 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 595.0
HFD2_k127_4211679_17 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 588.0
HFD2_k127_4211679_18 PFAM type II secretion system protein E K02283,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 564.0
HFD2_k127_4211679_19 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 566.0
HFD2_k127_4211679_2 efflux transmembrane transporter activity - - - 1.165e-254 809.0
HFD2_k127_4211679_20 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 541.0
HFD2_k127_4211679_21 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 557.0
HFD2_k127_4211679_22 ABC transporter K10441 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 538.0
HFD2_k127_4211679_23 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 527.0
HFD2_k127_4211679_24 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 494.0
HFD2_k127_4211679_25 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 454.0
HFD2_k127_4211679_26 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 417.0
HFD2_k127_4211679_27 ABC-type sugar transport system periplasmic component K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 400.0
HFD2_k127_4211679_28 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 355.0
HFD2_k127_4211679_29 4Fe-4S dicluster domain K07307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 328.0
HFD2_k127_4211679_3 FtsX-like permease family - - - 3.102e-243 777.0
HFD2_k127_4211679_30 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 309.0
HFD2_k127_4211679_31 SNARE associated Golgi protein K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 292.0
HFD2_k127_4211679_32 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 300.0
HFD2_k127_4211679_33 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004691 291.0
HFD2_k127_4211679_34 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000384 246.0
HFD2_k127_4211679_35 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000131 236.0
HFD2_k127_4211679_36 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000001203 228.0
HFD2_k127_4211679_37 Type II secretion system K12510 - - 0.0000000000000000000000000000000000000000000000000000000000008035 222.0
HFD2_k127_4211679_38 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000001379 203.0
HFD2_k127_4211679_39 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000000196 202.0
HFD2_k127_4211679_4 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.047e-226 713.0
HFD2_k127_4211679_40 type II secretion system protein K12511 - - 0.00000000000000000000000000000000000000000000000000001112 200.0
HFD2_k127_4211679_41 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000002291 198.0
HFD2_k127_4211679_42 NUBPL iron-transfer P-loop NTPase K02282 - - 0.00000000000000000000000000000000000000000000000000007108 203.0
HFD2_k127_4211679_43 formate dehydrogenase K00127,K08350 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.00000000000000000000000000000000000000000000002939 179.0
HFD2_k127_4211679_44 - - - - 0.0000000000000000000000000000000000000000006097 159.0
HFD2_k127_4211679_45 protein involved in formate dehydrogenase formation K02380 - - 0.00000000000000000000000000000000000000005941 160.0
HFD2_k127_4211679_46 PFAM Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000001091 145.0
HFD2_k127_4211679_47 Belongs to the UPF0312 family - - - 0.000000000000000000000000005609 117.0
HFD2_k127_4211679_48 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000001162 119.0
HFD2_k127_4211679_49 PFAM peptidase A24A, prepilin type IV - - - 0.00000000000000001408 90.0
HFD2_k127_4211679_5 MacB-like periplasmic core domain - - - 1.638e-218 704.0
HFD2_k127_4211679_50 Tetratricopeptide repeat - - - 0.0000000000000003762 89.0
HFD2_k127_4211679_51 TadE-like protein - - - 0.000000000000001386 84.0
HFD2_k127_4211679_52 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000002603 78.0
HFD2_k127_4211679_53 efflux transmembrane transporter activity - - - 0.0000000000007309 70.0
HFD2_k127_4211679_54 Glycosyltransferase family 87 - - - 0.00000000006093 75.0
HFD2_k127_4211679_55 Tetratricopeptide repeat - - - 0.000000003161 69.0
HFD2_k127_4211679_56 - - - - 0.0000003811 61.0
HFD2_k127_4211679_57 TadE-like protein - - - 0.00002984 52.0
HFD2_k127_4211679_58 Flp Fap pilin component K02651 - - 0.00003401 48.0
HFD2_k127_4211679_59 Flp Fap pilin component K02651 - - 0.00004319 48.0
HFD2_k127_4211679_6 MacB-like periplasmic core domain - - - 8.113e-217 699.0
HFD2_k127_4211679_60 Flp Fap pilin component K02651 - - 0.0000568 48.0
HFD2_k127_4211679_61 - - - - 0.00007119 53.0
HFD2_k127_4211679_62 SMART Tetratricopeptide domain protein - - - 0.00009279 54.0
HFD2_k127_4211679_7 Acyclic terpene utilisation family protein AtuA - - - 1.868e-214 673.0
HFD2_k127_4211679_8 efflux transmembrane transporter activity K02004 - - 3.577e-205 666.0
HFD2_k127_4211679_9 efflux transmembrane transporter activity K02004 - - 1.093e-204 664.0
HFD2_k127_4251623_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 334.0
HFD2_k127_4251623_1 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000009809 200.0
HFD2_k127_4251623_2 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000000000006482 123.0
HFD2_k127_4363330_0 lipopolysaccharide transport K22110 - - 0.0 1416.0
HFD2_k127_4363330_1 choline dehydrogenase activity - - - 1.379e-262 816.0
HFD2_k127_4363330_10 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 464.0
HFD2_k127_4363330_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 456.0
HFD2_k127_4363330_12 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 452.0
HFD2_k127_4363330_13 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 436.0
HFD2_k127_4363330_14 Proline racemase K12658 - 5.1.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 431.0
HFD2_k127_4363330_15 Dihydrodipicolinate synthetase family K21062 - 3.5.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 416.0
HFD2_k127_4363330_16 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007183 406.0
HFD2_k127_4363330_17 Cupin 2, conserved barrel domain protein K11477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 347.0
HFD2_k127_4363330_18 Major intrinsic protein K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 326.0
HFD2_k127_4363330_19 Glycogen recognition site of AMP-activated protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 325.0
HFD2_k127_4363330_2 Spermine/spermidine synthase domain K00797 - 2.5.1.16 9.919e-196 621.0
HFD2_k127_4363330_20 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 323.0
HFD2_k127_4363330_21 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000002193 269.0
HFD2_k127_4363330_22 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000001568 230.0
HFD2_k127_4363330_23 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000002242 218.0
HFD2_k127_4363330_24 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000109 184.0
HFD2_k127_4363330_25 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000906 177.0
HFD2_k127_4363330_26 - - - - 0.000000000000000000000000000000000000001399 152.0
HFD2_k127_4363330_27 S-adenosylmethionine decarboxylase K01611 - 4.1.1.50 0.0000000000000000000000000002927 120.0
HFD2_k127_4363330_28 2Fe-2S iron-sulfur cluster binding domain K00302 - 1.5.3.1 0.0000000000000000000000566 101.0
HFD2_k127_4363330_29 Transglycosylase associated protein - - - 0.00000000000000000000007746 100.0
HFD2_k127_4363330_3 gluconolactonase activity K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 597.0
HFD2_k127_4363330_30 hydroperoxide reductase activity - - - 0.000000000000000000006827 95.0
HFD2_k127_4363330_31 Domain of Unknown Function (DUF350) - - - 0.0000000000000001945 82.0
HFD2_k127_4363330_32 Transglutaminase-like superfamily - - - 0.00000000003736 78.0
HFD2_k127_4363330_34 Transmembrane anti-sigma factor - - - 0.000000005918 61.0
HFD2_k127_4363330_35 Putative zinc-finger - - - 0.0000001698 57.0
HFD2_k127_4363330_4 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 609.0
HFD2_k127_4363330_5 Pyridine nucleotide-disulphide oxidoreductase K03885,K10716 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 587.0
HFD2_k127_4363330_6 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 561.0
HFD2_k127_4363330_7 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 569.0
HFD2_k127_4363330_8 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005813 575.0
HFD2_k127_4363330_9 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 507.0
HFD2_k127_4401951_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1941.0
HFD2_k127_4401951_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1824.0
HFD2_k127_4401951_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000004906 158.0
HFD2_k127_4457657_0 PFAM type II secretion system protein E K02283,K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 571.0
HFD2_k127_4457657_1 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 340.0
HFD2_k127_4457657_10 response regulator K07685 - - 0.0000000000000000000000000000000000000000000001277 175.0
HFD2_k127_4457657_11 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000405 166.0
HFD2_k127_4457657_12 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000397 146.0
HFD2_k127_4457657_13 oxidoreductase activity K07114,K12511 - - 0.0000000000000000000000001162 120.0
HFD2_k127_4457657_14 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000003823 104.0
HFD2_k127_4457657_16 O-methyltransferase activity - - - 0.0000000000000000002349 91.0
HFD2_k127_4457657_17 PFAM peptidase A24A, prepilin type IV - - - 0.00000000000000004722 88.0
HFD2_k127_4457657_18 TadE-like protein - - - 0.0000000000004797 76.0
HFD2_k127_4457657_19 TadE-like protein - - - 0.000000000002234 74.0
HFD2_k127_4457657_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 347.0
HFD2_k127_4457657_20 Pkd domain containing protein - - - 0.0000007858 63.0
HFD2_k127_4457657_21 Tetratricopeptide repeat - - - 0.0000009467 60.0
HFD2_k127_4457657_3 Belongs to the GSP D family K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001272 286.0
HFD2_k127_4457657_4 domain, Protein K01212,K12287,K20276 - 3.2.1.65 0.0000000000000000000000000000000000000000000000000000000000000002351 248.0
HFD2_k127_4457657_5 Type II secretion system K12510 - - 0.00000000000000000000000000000000000000000000000000000001083 211.0
HFD2_k127_4457657_6 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000009471 197.0
HFD2_k127_4457657_7 Conserved repeat domain - - - 0.0000000000000000000000000000000000000000000000000003678 209.0
HFD2_k127_4457657_8 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000001535 199.0
HFD2_k127_4457657_9 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000000000000000000000000000000000000007754 187.0
HFD2_k127_4526405_0 Pyrrolo-quinoline quinone K00114 - 1.1.2.8 1.55e-294 913.0
HFD2_k127_4526405_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 1.044e-270 848.0
HFD2_k127_4526405_10 PFAM extracellular solute-binding protein, family 3 K16254 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 323.0
HFD2_k127_4526405_11 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 296.0
HFD2_k127_4526405_12 PQQ-dependent catabolism-associated beta-propeller protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003473 288.0
HFD2_k127_4526405_13 PFAM Cytochrome C K00406 - - 0.000000000000000000000000000000000000000003177 162.0
HFD2_k127_4526405_14 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000009441 162.0
HFD2_k127_4526405_15 KaiB K08481 - - 0.0000000000000000000000000000000000000002719 152.0
HFD2_k127_4526405_16 periplasmic or secreted lipoprotein - - - 0.000000000000000000000000000000000000004511 160.0
HFD2_k127_4526405_17 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 0.000000000000000000000000000000000002207 145.0
HFD2_k127_4526405_18 KaiB K08481 - - 0.00000000000000000000000000000004779 129.0
HFD2_k127_4526405_19 PFAM PRC-barrel domain - - - 0.000000000000000000000000004718 115.0
HFD2_k127_4526405_2 Pfam:KaiC K08482 - - 5.702e-223 707.0
HFD2_k127_4526405_20 - - - - 0.000000000000000000000008458 104.0
HFD2_k127_4526405_3 Prolyl oligopeptidase family - - - 1.158e-199 642.0
HFD2_k127_4526405_4 metal ion transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 546.0
HFD2_k127_4526405_5 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 452.0
HFD2_k127_4526405_6 beta' subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 401.0
HFD2_k127_4526405_7 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 398.0
HFD2_k127_4526405_8 cytochrome c oxidase K02351 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 349.0
HFD2_k127_4526405_9 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 331.0
HFD2_k127_4529723_0 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 559.0
HFD2_k127_4529723_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 476.0
HFD2_k127_4529723_10 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000001175 236.0
HFD2_k127_4529723_11 membrane - - - 0.0000000000000000000000000000000000000000000000000000000003892 219.0
HFD2_k127_4529723_12 SCO1/SenC - - - 0.0000000000000000000000000000000000000000000000000000007301 201.0
HFD2_k127_4529723_13 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000088 199.0
HFD2_k127_4529723_14 Recombinase - - - 0.0000000000000000000000000000000000000838 145.0
HFD2_k127_4529723_15 - - - - 0.000000000000000000000000000000000002067 158.0
HFD2_k127_4529723_16 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000003698 109.0
HFD2_k127_4529723_17 Protein of unknown function (DUF3142) - - - 0.000000000000006517 88.0
HFD2_k127_4529723_18 - - - - 0.00000000000003289 87.0
HFD2_k127_4529723_19 Carboxypeptidase regulatory-like domain - - - 0.0000000000006942 82.0
HFD2_k127_4529723_2 Multicopper oxidase K00368,K22349 - 1.16.3.3,1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 469.0
HFD2_k127_4529723_20 Recombinase - - - 0.00000008851 56.0
HFD2_k127_4529723_21 Carboxypeptidase regulatory-like domain - - - 0.0000001023 66.0
HFD2_k127_4529723_22 - - - - 0.000002271 61.0
HFD2_k127_4529723_3 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 413.0
HFD2_k127_4529723_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 351.0
HFD2_k127_4529723_5 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003375 282.0
HFD2_k127_4529723_6 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003888 254.0
HFD2_k127_4529723_7 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002202 258.0
HFD2_k127_4529723_8 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001272 265.0
HFD2_k127_4529723_9 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000001108 239.0
HFD2_k127_4605172_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1226.0
HFD2_k127_4605172_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 4.602e-286 901.0
HFD2_k127_4605172_10 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 432.0
HFD2_k127_4605172_11 PepSY-associated TM region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 393.0
HFD2_k127_4605172_12 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 400.0
HFD2_k127_4605172_13 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 359.0
HFD2_k127_4605172_14 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 342.0
HFD2_k127_4605172_15 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 326.0
HFD2_k127_4605172_16 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 332.0
HFD2_k127_4605172_17 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 325.0
HFD2_k127_4605172_18 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 307.0
HFD2_k127_4605172_19 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000009001 231.0
HFD2_k127_4605172_2 Carboxypeptidase regulatory-like domain - - - 1.078e-267 852.0
HFD2_k127_4605172_20 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000002855 224.0
HFD2_k127_4605172_21 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000005648 214.0
HFD2_k127_4605172_22 SCO1/SenC - - - 0.0000000000000000000000000000000000000000000000000000001154 203.0
HFD2_k127_4605172_23 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000006484 214.0
HFD2_k127_4605172_24 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000001824 184.0
HFD2_k127_4605172_25 Domain of unknown function (DUF4114) - - - 0.000000000000000000000000000000000000000000001097 192.0
HFD2_k127_4605172_26 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000002455 169.0
HFD2_k127_4605172_27 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000004365 166.0
HFD2_k127_4605172_28 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.5 0.0000000000000000000000000000000000004148 149.0
HFD2_k127_4605172_29 SCO1/SenC K07152 - - 0.000000000000000000000000000000000002766 145.0
HFD2_k127_4605172_3 TonB dependent receptor K16090 - - 2.922e-224 719.0
HFD2_k127_4605172_30 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000009552 141.0
HFD2_k127_4605172_31 - - - - 0.00000000000000000000000000000002621 143.0
HFD2_k127_4605172_32 Parallel beta-helix repeats - - - 0.00000000000000000000000000002598 128.0
HFD2_k127_4605172_33 - - - - 0.0000000000000000000000000001622 132.0
HFD2_k127_4605172_35 cell redox homeostasis K03671 - - 0.0000000000000000000004027 104.0
HFD2_k127_4605172_36 Protein of unknown function with PCYCGC motif - - - 0.00000000000000002335 88.0
HFD2_k127_4605172_37 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000005537 81.0
HFD2_k127_4605172_38 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000491 79.0
HFD2_k127_4605172_39 AraC-like ligand binding domain - - - 0.000000000000006917 81.0
HFD2_k127_4605172_4 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 497.0
HFD2_k127_4605172_40 Lysin motif - - - 0.0000000005158 71.0
HFD2_k127_4605172_41 Tetratricopeptide repeat - - - 0.000000005825 68.0
HFD2_k127_4605172_42 exo-alpha-(2->6)-sialidase activity - - - 0.000000006662 64.0
HFD2_k127_4605172_44 Copper binding periplasmic protein CusF - - - 0.00000006682 60.0
HFD2_k127_4605172_45 - - - - 0.000001612 50.0
HFD2_k127_4605172_5 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 477.0
HFD2_k127_4605172_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 467.0
HFD2_k127_4605172_7 Multicopper oxidase K14588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 449.0
HFD2_k127_4605172_8 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 443.0
HFD2_k127_4605172_9 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005417 404.0
HFD2_k127_4626471_0 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 515.0
HFD2_k127_4626471_1 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 519.0
HFD2_k127_4626471_2 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 373.0
HFD2_k127_4626471_3 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 366.0
HFD2_k127_4626471_4 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000000000000000000004451 120.0
HFD2_k127_4626471_5 - - - - 0.00000000000000000000004328 100.0
HFD2_k127_4683624_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 5.629e-200 636.0
HFD2_k127_4683624_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 558.0
HFD2_k127_4683624_2 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 439.0
HFD2_k127_4683624_3 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000003982 179.0
HFD2_k127_4683904_0 serine-type exopeptidase activity K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 5.261e-303 945.0
HFD2_k127_4683904_1 Sigma-70 region 2 K03088 - - 1.97e-224 700.0
HFD2_k127_4683904_10 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008965 320.0
HFD2_k127_4683904_11 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 323.0
HFD2_k127_4683904_12 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003327 265.0
HFD2_k127_4683904_13 Pfam RibD C-terminal domain K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000002672 244.0
HFD2_k127_4683904_14 ABC-type polar amino acid transport system ATPase component K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000001239 232.0
HFD2_k127_4683904_15 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001269 226.0
HFD2_k127_4683904_16 Disulphide isomerase - - - 0.00000000000000000000000000000000000000000000000000000003106 199.0
HFD2_k127_4683904_17 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000002289 175.0
HFD2_k127_4683904_18 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000000000000000000000004317 148.0
HFD2_k127_4683904_19 TonB dependent receptor K16087 - - 0.00000000000000000000000000000000002477 147.0
HFD2_k127_4683904_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006506 586.0
HFD2_k127_4683904_20 YoeB-like toxin of bacterial type II toxin-antitoxin system K19158 - - 0.00000000000000000000000000000001255 130.0
HFD2_k127_4683904_21 - - - - 0.00000000000000000000000000002775 123.0
HFD2_k127_4683904_22 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000002318 116.0
HFD2_k127_4683904_23 PIN domain - - - 0.000000000000000000000002258 109.0
HFD2_k127_4683904_24 Antitoxin component of a toxin-antitoxin (TA) module K19159 - - 0.00000000000000000000006098 102.0
HFD2_k127_4683904_25 AraC-like ligand binding domain - - - 0.00000000000000006162 85.0
HFD2_k127_4683904_26 Aspartyl protease - - - 0.00000003694 66.0
HFD2_k127_4683904_27 YCII-related domain - - - 0.00000005622 55.0
HFD2_k127_4683904_28 PEP-CTERM motif - - - 0.0000001269 61.0
HFD2_k127_4683904_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 580.0
HFD2_k127_4683904_4 Glycosyl hydrolase family 47 K01230 - 3.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 544.0
HFD2_k127_4683904_5 proline dipeptidase activity K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 498.0
HFD2_k127_4683904_6 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 497.0
HFD2_k127_4683904_7 Aminotransferase class-III K00823 - 2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 488.0
HFD2_k127_4683904_8 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 443.0
HFD2_k127_4683904_9 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006026 362.0
HFD2_k127_4748850_0 serine-type peptidase activity - - - 1.224e-224 705.0
HFD2_k127_4748850_1 ThiS family K21029,K21147 - 2.7.7.80,2.8.1.11 9.258e-197 624.0
HFD2_k127_4748850_2 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000001031 263.0
HFD2_k127_4748850_3 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003223 252.0
HFD2_k127_4748850_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739,K01761 - 2.5.1.48,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000001956 217.0
HFD2_k127_4748850_5 JAB/MPN domain - - - 0.000000000000000000000000000000000000003264 154.0
HFD2_k127_484177_0 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 6.087e-224 707.0
HFD2_k127_484177_10 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 476.0
HFD2_k127_484177_11 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 429.0
HFD2_k127_484177_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 412.0
HFD2_k127_484177_13 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 384.0
HFD2_k127_484177_14 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 373.0
HFD2_k127_484177_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 361.0
HFD2_k127_484177_16 thiamine diphosphate biosynthetic process K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 353.0
HFD2_k127_484177_17 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 344.0
HFD2_k127_484177_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000654 248.0
HFD2_k127_484177_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 5.069e-196 622.0
HFD2_k127_484177_20 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000003227 211.0
HFD2_k127_484177_21 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000002104 193.0
HFD2_k127_484177_22 Lamin Tail Domain K07004 - - 0.000000000000000000000000000000000000000000000000001476 208.0
HFD2_k127_484177_23 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000008497 168.0
HFD2_k127_484177_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000001229 165.0
HFD2_k127_484177_25 lipoprotein localization to outer membrane K02004 - - 0.0000000000000000000000000000000000000000005764 180.0
HFD2_k127_484177_26 Forkhead associated domain - - - 0.000000000000000000000000000000000000001519 166.0
HFD2_k127_484177_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000001686 151.0
HFD2_k127_484177_28 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000008982 153.0
HFD2_k127_484177_29 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000001255 146.0
HFD2_k127_484177_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 596.0
HFD2_k127_484177_30 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000006742 142.0
HFD2_k127_484177_31 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000002693 126.0
HFD2_k127_484177_32 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000001125 124.0
HFD2_k127_484177_33 Ferredoxin - - - 0.0000000000000000000000003436 109.0
HFD2_k127_484177_34 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000000003923 116.0
HFD2_k127_484177_35 Belongs to the peptidase S1C family - - - 0.000000000000000005323 98.0
HFD2_k127_484177_36 - - - - 0.00000000000004578 83.0
HFD2_k127_484177_37 thiamine biosynthesis protein ThiS K03154 - - 0.0000000000007383 74.0
HFD2_k127_484177_38 GMP synthase (glutamine-hydrolyzing) activity K01951 - 6.3.5.2 0.00000007101 63.0
HFD2_k127_484177_39 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00006048 56.0
HFD2_k127_484177_4 RQC K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 527.0
HFD2_k127_484177_40 Tetratricopeptide repeat-like domain - - - 0.00006771 53.0
HFD2_k127_484177_41 Putative zinc-finger - - - 0.0006895 50.0
HFD2_k127_484177_5 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 517.0
HFD2_k127_484177_6 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 501.0
HFD2_k127_484177_7 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 496.0
HFD2_k127_484177_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 498.0
HFD2_k127_484177_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 491.0
HFD2_k127_4856476_0 Peptidase M14, carboxypeptidase A - - - 0.0 1388.0
HFD2_k127_4856476_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1051.0
HFD2_k127_4856476_10 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 394.0
HFD2_k127_4856476_11 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 391.0
HFD2_k127_4856476_12 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 387.0
HFD2_k127_4856476_13 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 357.0
HFD2_k127_4856476_14 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 358.0
HFD2_k127_4856476_15 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002683 279.0
HFD2_k127_4856476_16 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000005851 236.0
HFD2_k127_4856476_17 GAF domain K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000000000002091 202.0
HFD2_k127_4856476_18 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000000000000000187 191.0
HFD2_k127_4856476_19 Scaffold protein Nfu/NifU N terminal - - - 0.00000000000000000000000000000000000000000000000000007007 193.0
HFD2_k127_4856476_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 662.0
HFD2_k127_4856476_20 Belongs to the glycosyl hydrolase 5 (cellulase A) family K19355 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004567,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010412,GO:0015923,GO:0016052,GO:0016787,GO:0016798,GO:0016985,GO:0016998,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046355,GO:0071554,GO:0071704,GO:1901575 3.2.1.78 0.0000000000000000000000000000000000000000000000000006762 205.0
HFD2_k127_4856476_21 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000001106 180.0
HFD2_k127_4856476_22 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000001351 171.0
HFD2_k127_4856476_23 Cell wall-associated hydrolase (invasion-associated protein) - - - 0.000000000000009297 82.0
HFD2_k127_4856476_24 PFAM CBS domain containing protein K06189 - - 0.0000000000001194 75.0
HFD2_k127_4856476_26 glycosyl transferase, family 39 - - - 0.0003712 53.0
HFD2_k127_4856476_27 - - - - 0.0008962 48.0
HFD2_k127_4856476_3 Elongation factor SelB, winged helix K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 540.0
HFD2_k127_4856476_4 amino acid transport K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 527.0
HFD2_k127_4856476_5 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005625 516.0
HFD2_k127_4856476_6 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 420.0
HFD2_k127_4856476_7 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 404.0
HFD2_k127_4856476_8 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 407.0
HFD2_k127_4856476_9 glycosyl transferase group 1 K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 407.0
HFD2_k127_4959880_0 ABC transporter transmembrane region K11085 - - 3.139e-236 744.0
HFD2_k127_4959880_1 pfkB family carbohydrate kinase K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 587.0
HFD2_k127_4959880_10 Phosphate acetyl/butaryl transferase K00625,K13788 GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 341.0
HFD2_k127_4959880_11 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 313.0
HFD2_k127_4959880_12 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 321.0
HFD2_k127_4959880_13 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006836 312.0
HFD2_k127_4959880_14 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006884 289.0
HFD2_k127_4959880_15 Cytidylyltransferase K00983 - 2.7.7.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001252 278.0
HFD2_k127_4959880_16 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000000000000000000000000000000000001925 259.0
HFD2_k127_4959880_17 Hexapeptide repeat of succinyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007247 247.0
HFD2_k127_4959880_18 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002182 252.0
HFD2_k127_4959880_19 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000006715 226.0
HFD2_k127_4959880_2 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 567.0
HFD2_k127_4959880_20 PFAM Short-chain dehydrogenase reductase SDR K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000003456 203.0
HFD2_k127_4959880_21 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000003583 206.0
HFD2_k127_4959880_22 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000000000001325 204.0
HFD2_k127_4959880_23 - - - - 0.0000000000000000000000000000000000000000000000000009322 197.0
HFD2_k127_4959880_24 TIGRFAM Sialic acid O-acyltransferase, NeuD - - - 0.000000000000000000000000000000000000000000000000001559 189.0
HFD2_k127_4959880_25 tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000001812 207.0
HFD2_k127_4959880_26 WbqC-like protein family - - - 0.0000000000000000000000000000000000000000000002476 177.0
HFD2_k127_4959880_27 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000005274 114.0
HFD2_k127_4959880_28 Protein of unknown function DUF115 - - - 0.00000000000000000000001504 111.0
HFD2_k127_4959880_29 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000001313 99.0
HFD2_k127_4959880_3 Mur ligase middle domain K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 474.0
HFD2_k127_4959880_30 Sensory domain in DIguanylate Cyclases and Two-component system - - - 0.00000000000003331 80.0
HFD2_k127_4959880_31 von Willebrand factor, type A - - - 0.00000006057 65.0
HFD2_k127_4959880_4 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 493.0
HFD2_k127_4959880_5 ADP-glyceromanno-heptose 6-epimerase activity K01710,K01784,K21211 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 434.0
HFD2_k127_4959880_6 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 437.0
HFD2_k127_4959880_7 NeuB family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 397.0
HFD2_k127_4959880_8 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 387.0
HFD2_k127_4959880_9 UDP-N-acetylglucosamine 2-epimerase K08068,K18429 - 3.2.1.183,3.2.1.184 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 379.0
HFD2_k127_5039539_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 1.745e-304 952.0
HFD2_k127_5039539_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 3.997e-287 910.0
HFD2_k127_5039539_10 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000000000000000004095 146.0
HFD2_k127_5039539_11 Tetratricopeptide repeat - - - 0.000000000000000000000000000000006312 138.0
HFD2_k127_5039539_13 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000001468 91.0
HFD2_k127_5039539_2 Domain of unknown function (DUF5117) - - - 5.828e-252 794.0
HFD2_k127_5039539_3 peptidase M24B X-Pro dipeptidase aminopeptidase domain protein K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 451.0
HFD2_k127_5039539_4 SMART tyrosine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 373.0
HFD2_k127_5039539_5 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 288.0
HFD2_k127_5039539_6 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005598 289.0
HFD2_k127_5039539_7 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000004163 254.0
HFD2_k127_5039539_8 heme binding K21472 - - 0.00000000000000000000000000000000000000000000003786 177.0
HFD2_k127_5039539_9 GDP-mannose mannosyl hydrolase activity K01858,K03207,K03574 - 3.6.1.55,5.5.1.4 0.00000000000000000000000000000000000000000001475 168.0
HFD2_k127_505305_0 Carboxypeptidase regulatory-like domain - - - 4.037e-287 916.0
HFD2_k127_505305_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 8.828e-286 899.0
HFD2_k127_505305_10 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000003967 132.0
HFD2_k127_505305_11 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000000000003207 116.0
HFD2_k127_505305_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000003046 108.0
HFD2_k127_505305_13 cheY-homologous receiver domain K11443 - - 0.00000000000000000000002504 104.0
HFD2_k127_505305_14 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000003419 102.0
HFD2_k127_505305_15 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.00000000000000000006211 99.0
HFD2_k127_505305_16 YCII-related domain - - - 0.0000000000000000001117 92.0
HFD2_k127_505305_17 YceI-like domain - - - 0.00000000001045 73.0
HFD2_k127_505305_18 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000007653 50.0
HFD2_k127_505305_2 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 4.365e-195 625.0
HFD2_k127_505305_3 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 540.0
HFD2_k127_505305_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009061 404.0
HFD2_k127_505305_5 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001604 286.0
HFD2_k127_505305_6 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004058 263.0
HFD2_k127_505305_7 Zn-dependent hydrolase, glyoxylase - - - 0.000000000000000000000000000000000000000000000000000002258 202.0
HFD2_k127_505305_8 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000000000000000004646 142.0
HFD2_k127_505305_9 STAS domain K04749 - - 0.00000000000000000000000000000000018 135.0
HFD2_k127_5075946_0 Protein of unknown function (DUF763) K09003 - - 5.623e-196 617.0
HFD2_k127_5075946_1 Vault protein inter-alpha-trypsin domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 594.0
HFD2_k127_5075946_10 Penicillin-binding Protein K05364 - - 0.00000000000000000000000000000000000000000008318 181.0
HFD2_k127_5075946_11 Protein tyrosine kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000002482 155.0
HFD2_k127_5075946_12 Belongs to the SEDS family K03588 GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - 0.0000000000000000000000000000000002238 150.0
HFD2_k127_5075946_13 Belongs to the ompA family - - - 0.00000000000000000000001598 113.0
HFD2_k127_5075946_14 sigma factor antagonist activity K04757 - 2.7.11.1 0.000000000001767 81.0
HFD2_k127_5075946_15 (FHA) domain - - - 0.00000000002698 74.0
HFD2_k127_5075946_16 Protein of unknown function (DUF2662) - - - 0.000001366 59.0
HFD2_k127_5075946_17 STAS domain K06378 - - 0.000004126 54.0
HFD2_k127_5075946_2 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 521.0
HFD2_k127_5075946_3 ATPases associated with a variety of cellular activities K10823,K10824 - 3.6.3.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 445.0
HFD2_k127_5075946_4 Belongs to the ABC transporter superfamily K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 421.0
HFD2_k127_5075946_5 'ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 355.0
HFD2_k127_5075946_6 transporter, permease K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 291.0
HFD2_k127_5075946_7 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007509 267.0
HFD2_k127_5075946_8 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000005818 187.0
HFD2_k127_5075946_9 HD domain - - - 0.000000000000000000000000000000000000000000000634 182.0
HFD2_k127_5136679_0 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 471.0
HFD2_k127_5136679_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 430.0
HFD2_k127_5136679_10 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000000000001611 258.0
HFD2_k127_5136679_11 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000006093 239.0
HFD2_k127_5136679_12 Sulfate ABC transporter substrate-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000003041 237.0
HFD2_k127_5136679_13 orotate phosphoribosyltransferase activity K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000005098 216.0
HFD2_k127_5136679_14 tRNA pseudouridine synthase K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000001168 205.0
HFD2_k127_5136679_15 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000003788 198.0
HFD2_k127_5136679_16 TIGRFAM sulfate ABC transporter, inner membrane subunit CysT K02046 - - 0.000000000000000000000000000000000000000000000000001189 194.0
HFD2_k127_5136679_17 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000005516 199.0
HFD2_k127_5136679_18 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000002142 181.0
HFD2_k127_5136679_19 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02342,K03763 - 2.7.7.7 0.00000000000000000000000000000000000000001622 163.0
HFD2_k127_5136679_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 392.0
HFD2_k127_5136679_20 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.000000000000000000000000000000000000057 153.0
HFD2_k127_5136679_21 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000006331 136.0
HFD2_k127_5136679_22 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000000000105 104.0
HFD2_k127_5136679_23 PFAM SNARE associated Golgi protein - - - 0.000000000000000002235 94.0
HFD2_k127_5136679_24 SNARE associated Golgi protein - - - 0.00000000000000004544 89.0
HFD2_k127_5136679_25 - - - - 0.0000000003334 70.0
HFD2_k127_5136679_26 RDD family - - - 0.000000000857 65.0
HFD2_k127_5136679_27 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 0.000001164 53.0
HFD2_k127_5136679_28 Protein of unknown function (DUF2490) - - - 0.000008486 56.0
HFD2_k127_5136679_29 of the alpha beta superfamily K06889 - - 0.0001917 53.0
HFD2_k127_5136679_3 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007901 340.0
HFD2_k127_5136679_4 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008818 307.0
HFD2_k127_5136679_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 294.0
HFD2_k127_5136679_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001058 283.0
HFD2_k127_5136679_7 Oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005994 277.0
HFD2_k127_5136679_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000001863 259.0
HFD2_k127_5136679_9 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001586 256.0
HFD2_k127_5154869_0 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007712 483.0
HFD2_k127_5154869_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 430.0
HFD2_k127_5154869_10 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000009191 162.0
HFD2_k127_5154869_11 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000005533 150.0
HFD2_k127_5154869_12 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000003522 144.0
HFD2_k127_5154869_14 Transcriptional repressor, CopY family - - - 0.000000000000000000000000000000000003709 140.0
HFD2_k127_5154869_16 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.0000000005443 70.0
HFD2_k127_5154869_2 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 426.0
HFD2_k127_5154869_3 TAP-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 353.0
HFD2_k127_5154869_4 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 345.0
HFD2_k127_5154869_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000001985 238.0
HFD2_k127_5154869_6 - - - - 0.0000000000000000000000000000000000000000000000000000000005718 211.0
HFD2_k127_5154869_7 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000008843 211.0
HFD2_k127_5154869_8 - - - - 0.000000000000000000000000000000000000000000005481 184.0
HFD2_k127_5154869_9 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000007012 169.0
HFD2_k127_5186108_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.805e-258 805.0
HFD2_k127_5186108_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 533.0
HFD2_k127_5186108_2 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008299 347.0
HFD2_k127_5186108_3 Ornithine cyclodeaminase/mu-crystallin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 328.0
HFD2_k127_5186108_4 PFAM Nickel cobalt transporter, high-affinity - - - 0.0000000000000000000000000000000000000000000000008053 183.0
HFD2_k127_5186108_5 Ankyrin repeat K06867 - - 0.0000000000000000000000000000000000000000000001277 175.0
HFD2_k127_5186108_6 sequence-specific DNA binding K01697,K01738 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 0.0000000000000000000000000003569 115.0
HFD2_k127_5186108_7 NHL repeat - - - 0.00000546 48.0
HFD2_k127_5262084_0 COG NOG06097 non supervised orthologous group - - - 1.169e-266 847.0
HFD2_k127_5262084_1 Belongs to the glycosyl hydrolase 2 family - - - 1.272e-253 822.0
HFD2_k127_5262084_2 polygalacturonase activity K01184 - 3.2.1.15 9.326e-198 626.0
HFD2_k127_5262084_3 Right handed beta helix region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 600.0
HFD2_k127_5262084_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005962 461.0
HFD2_k127_5262084_5 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 417.0
HFD2_k127_5262084_6 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 312.0
HFD2_k127_5281077_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 489.0
HFD2_k127_5281077_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 473.0
HFD2_k127_5281077_2 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 310.0
HFD2_k127_5281077_3 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000007857 224.0
HFD2_k127_5281077_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000006533 232.0
HFD2_k127_5281077_5 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000000000005956 152.0
HFD2_k127_5281077_6 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000634 146.0
HFD2_k127_5281077_7 Protein of unknown function (DUF4231) - - - 0.00000000000000000002538 102.0
HFD2_k127_5281077_8 radical SAM domain protein - - - 0.0000001331 55.0
HFD2_k127_5396186_0 radical SAM domain protein - - - 4.498e-288 894.0
HFD2_k127_5396186_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.237e-196 637.0
HFD2_k127_5396186_10 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 297.0
HFD2_k127_5396186_11 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 294.0
HFD2_k127_5396186_12 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006877 278.0
HFD2_k127_5396186_13 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000002711 275.0
HFD2_k127_5396186_14 Hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007562 263.0
HFD2_k127_5396186_15 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000005475 238.0
HFD2_k127_5396186_16 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000001409 229.0
HFD2_k127_5396186_17 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000002889 216.0
HFD2_k127_5396186_18 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000003233 201.0
HFD2_k127_5396186_19 Nucleotidyl transferase K00966,K16881 - 2.7.7.13,5.4.2.8 0.0000000000000000000000000000000000000000000000000005948 196.0
HFD2_k127_5396186_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 621.0
HFD2_k127_5396186_20 - - - - 0.0000000000000000000000000000000000000000000002489 175.0
HFD2_k127_5396186_21 oxidation-reduction process K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000003135 164.0
HFD2_k127_5396186_22 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000192 168.0
HFD2_k127_5396186_24 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.00000000000000000000000000000000000003304 156.0
HFD2_k127_5396186_25 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000005837 135.0
HFD2_k127_5396186_26 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000001524 129.0
HFD2_k127_5396186_27 peptidase inhibitor activity - - - 0.000000000000000000000000007021 123.0
HFD2_k127_5396186_28 - - - - 0.0000000000000000001766 98.0
HFD2_k127_5396186_29 PFAM Endonuclease Exonuclease phosphatase - - - 0.000000000002514 77.0
HFD2_k127_5396186_3 class II (D K K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 605.0
HFD2_k127_5396186_4 tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 534.0
HFD2_k127_5396186_5 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 483.0
HFD2_k127_5396186_6 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 461.0
HFD2_k127_5396186_7 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 393.0
HFD2_k127_5396186_8 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 384.0
HFD2_k127_5396186_9 Belongs to the arginase family K01476 GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 327.0
HFD2_k127_5406887_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 464.0
HFD2_k127_5406887_1 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 299.0
HFD2_k127_5406887_2 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000001946 252.0
HFD2_k127_5406887_3 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000004523 176.0
HFD2_k127_5406887_5 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000009237 124.0
HFD2_k127_5475472_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 355.0
HFD2_k127_5475472_1 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 354.0
HFD2_k127_5475472_2 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000003423 186.0
HFD2_k127_5475472_3 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000000000000000000000000000000000000002274 158.0
HFD2_k127_5475472_4 Ankyrin repeat - - - 0.00000000000000000000000006342 118.0
HFD2_k127_5475472_5 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000003675 108.0
HFD2_k127_5475472_6 response regulator, receiver - - - 0.000000000000000000000001934 112.0
HFD2_k127_5475472_7 Transglycosylase SLT domain - - - 0.000000000000000000009283 93.0
HFD2_k127_5475472_8 Cupin 2, conserved barrel domain protein K21700 - - 0.000000000000000562 82.0
HFD2_k127_5475472_9 Pfam Plasmid stabilisation system protein - - - 0.0000002377 54.0
HFD2_k127_5482452_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.716e-276 861.0
HFD2_k127_5482452_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 6.993e-259 813.0
HFD2_k127_5482452_10 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 - 2.4.2.8,6.3.4.19 0.00000000000000000000000000000000001062 149.0
HFD2_k127_5482452_11 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000203 121.0
HFD2_k127_5482452_12 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000002867 114.0
HFD2_k127_5482452_13 Lipopolysaccharide-assembly - - - 0.000000000000001394 83.0
HFD2_k127_5482452_14 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000009782 75.0
HFD2_k127_5482452_15 N-formylglutamate amidohydrolase - - - 0.0000000118 62.0
HFD2_k127_5482452_2 Peptidase S46 - - - 2.651e-230 732.0
HFD2_k127_5482452_3 PFAM UvrD REP helicase K03657 - 3.6.4.12 6.063e-219 703.0
HFD2_k127_5482452_4 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 407.0
HFD2_k127_5482452_5 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 381.0
HFD2_k127_5482452_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 350.0
HFD2_k127_5482452_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001405 284.0
HFD2_k127_5482452_8 - - - - 0.00000000000000000000000000000000000000000000000004254 194.0
HFD2_k127_5482452_9 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000006352 189.0
HFD2_k127_5562564_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 3.648e-214 675.0
HFD2_k127_5562564_1 sequence-specific DNA binding K01697,K01738 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005251 496.0
HFD2_k127_5562564_10 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000002151 250.0
HFD2_k127_5562564_11 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000000000000000001175 223.0
HFD2_k127_5562564_12 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000002477 220.0
HFD2_k127_5562564_13 lipopolysaccharide heptosyltransferase K02841,K02843 - - 0.0000000000000000000000000000000000000000000000000000000165 210.0
HFD2_k127_5562564_14 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000003628 186.0
HFD2_k127_5562564_15 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000005605 186.0
HFD2_k127_5562564_16 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000423 176.0
HFD2_k127_5562564_17 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000002249 165.0
HFD2_k127_5562564_18 Domain of unknown function (DUF4252) - - - 0.00000000000000000000000000000000000000003346 159.0
HFD2_k127_5562564_19 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000002378 156.0
HFD2_k127_5562564_2 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 516.0
HFD2_k127_5562564_20 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000002462 144.0
HFD2_k127_5562564_21 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K13819 - - 0.000000000000000000000001094 107.0
HFD2_k127_5562564_22 helix_turn_helix, arabinose operon control protein K07506 - - 0.000000000000000000000002449 115.0
HFD2_k127_5562564_23 Polysaccharide biosynthesis protein K12454 - 5.1.3.10 0.000000000000000000008426 104.0
HFD2_k127_5562564_24 multi-organism process K03195 - - 0.00000000000004722 84.0
HFD2_k127_5562564_25 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000137 81.0
HFD2_k127_5562564_26 Protein of unknown function (DUF3108) - - - 0.000000000001603 78.0
HFD2_k127_5562564_27 HEAT repeat - - - 0.0000001274 62.0
HFD2_k127_5562564_29 - - - - 0.00004455 53.0
HFD2_k127_5562564_3 C-terminal, D2-small domain, of ClpB protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 458.0
HFD2_k127_5562564_30 VWA domain containing CoxE-like protein - - - 0.0001084 54.0
HFD2_k127_5562564_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 447.0
HFD2_k127_5562564_5 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 413.0
HFD2_k127_5562564_6 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 390.0
HFD2_k127_5562564_7 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 343.0
HFD2_k127_5562564_8 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000139 275.0
HFD2_k127_5562564_9 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003494 265.0
HFD2_k127_5604412_0 cellulose binding - - - 1.257e-294 937.0
HFD2_k127_5604412_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01847,K01848 - 5.4.99.2 5.277e-229 721.0
HFD2_k127_5604412_10 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006341 328.0
HFD2_k127_5604412_11 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 322.0
HFD2_k127_5604412_12 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 319.0
HFD2_k127_5604412_13 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006361 290.0
HFD2_k127_5604412_14 COG0515 Serine threonine protein K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000002437 238.0
HFD2_k127_5604412_15 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000000001103 216.0
HFD2_k127_5604412_16 PQQ-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000008241 226.0
HFD2_k127_5604412_17 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000004607 203.0
HFD2_k127_5604412_19 PFAM Forkhead-associated protein - - - 0.0000000000000000000008431 102.0
HFD2_k127_5604412_2 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 434.0
HFD2_k127_5604412_20 Yip1 domain - - - 0.0000000000000000001827 98.0
HFD2_k127_5604412_21 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000004259 73.0
HFD2_k127_5604412_22 RDD family - - - 0.000000001167 65.0
HFD2_k127_5604412_23 TIGRFAM TonB - - - 0.0000002557 61.0
HFD2_k127_5604412_3 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 406.0
HFD2_k127_5604412_4 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 379.0
HFD2_k127_5604412_5 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 353.0
HFD2_k127_5604412_6 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 346.0
HFD2_k127_5604412_7 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 334.0
HFD2_k127_5604412_8 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 336.0
HFD2_k127_5604412_9 polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 325.0
HFD2_k127_5631624_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 565.0
HFD2_k127_5631624_1 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 456.0
HFD2_k127_5631624_10 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001031 288.0
HFD2_k127_5631624_11 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002415 274.0
HFD2_k127_5631624_12 Mo-molybdopterin cofactor biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001068 279.0
HFD2_k127_5631624_13 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000009707 258.0
HFD2_k127_5631624_14 Pfam Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003519 240.0
HFD2_k127_5631624_15 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000006887 131.0
HFD2_k127_5631624_16 - - - - 0.000000000000000000000000006894 117.0
HFD2_k127_5631624_17 DNA polymerase K02347 - - 0.00000000000000000000000003818 113.0
HFD2_k127_5631624_18 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000002652 89.0
HFD2_k127_5631624_2 belongs to the lyase 1 family. Argininosuccinate lyase subfamily K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 382.0
HFD2_k127_5631624_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 371.0
HFD2_k127_5631624_4 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 364.0
HFD2_k127_5631624_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 356.0
HFD2_k127_5631624_6 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 336.0
HFD2_k127_5631624_7 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 329.0
HFD2_k127_5631624_8 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008466 314.0
HFD2_k127_5631624_9 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 295.0
HFD2_k127_572373_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.992e-310 991.0
HFD2_k127_572373_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.163e-255 807.0
HFD2_k127_572373_10 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 465.0
HFD2_k127_572373_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 415.0
HFD2_k127_572373_12 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 415.0
HFD2_k127_572373_13 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 404.0
HFD2_k127_572373_14 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 384.0
HFD2_k127_572373_15 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 383.0
HFD2_k127_572373_16 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006586 370.0
HFD2_k127_572373_17 transferase activity, transferring glycosyl groups K16150 - 2.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 373.0
HFD2_k127_572373_18 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 364.0
HFD2_k127_572373_19 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 355.0
HFD2_k127_572373_2 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 580.0
HFD2_k127_572373_20 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 325.0
HFD2_k127_572373_21 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 319.0
HFD2_k127_572373_22 PFAM polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002325 282.0
HFD2_k127_572373_23 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001646 286.0
HFD2_k127_572373_24 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001416 282.0
HFD2_k127_572373_25 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000002383 258.0
HFD2_k127_572373_26 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000241 252.0
HFD2_k127_572373_27 eight transmembrane protein EpsH - - - 0.0000000000000000000000000000000000000000000000000000000000000001506 233.0
HFD2_k127_572373_28 AAA domain K02450 - - 0.000000000000000000000000000000000000000000000000000000000000002937 228.0
HFD2_k127_572373_29 Cys Met metabolism K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000381 209.0
HFD2_k127_572373_3 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 574.0
HFD2_k127_572373_30 beta-fructofuranosidase activity - - - 0.000000000000000000000000000000000000000000000000000005068 213.0
HFD2_k127_572373_31 Heparinase - - - 0.00000000000000000000000000000000000000000000000000007123 203.0
HFD2_k127_572373_32 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000002365 194.0
HFD2_k127_572373_33 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000009816 194.0
HFD2_k127_572373_34 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000002032 184.0
HFD2_k127_572373_35 Photosynthesis system II assembly factor YCF48 - - - 0.0000000000000000000000000000000000000000000000004143 189.0
HFD2_k127_572373_36 Protein of unknown function (DUF3485) - - - 0.00000000000000000000000000000000000002271 152.0
HFD2_k127_572373_37 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.00000000000000000000000000000000000002853 157.0
HFD2_k127_572373_38 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000854 153.0
HFD2_k127_572373_39 Chain length determinant protein - - - 0.000000000000000000000000000000001361 147.0
HFD2_k127_572373_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009753 537.0
HFD2_k127_572373_40 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000005312 127.0
HFD2_k127_572373_41 aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.000000000000000000000000000001943 131.0
HFD2_k127_572373_42 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000254 127.0
HFD2_k127_572373_43 Predicted membrane protein (DUF2085) - - - 0.000000000000000000000000006919 117.0
HFD2_k127_572373_44 Belongs to the glycosyl hydrolase family 6 K19668 - 3.2.1.91 0.000000000000000000159 105.0
HFD2_k127_572373_46 Transcriptional regulator, AraC family K18991 - - 0.00000000000000697 79.0
HFD2_k127_572373_47 ErfK YbiS YcfS YnhG - - - 0.000000000000009319 87.0
HFD2_k127_572373_48 PFAM Polysaccharide export protein K01991 - - 0.00000000000001488 85.0
HFD2_k127_572373_49 - - - - 0.00000000000006612 76.0
HFD2_k127_572373_5 Acyl-CoA dehydrogenase, C-terminal domain K16173 - 1.3.99.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 525.0
HFD2_k127_572373_50 Alpha-L-rhamnosidase - - - 0.0000000000002011 85.0
HFD2_k127_572373_51 DUF218 domain - - - 0.0000000000003394 77.0
HFD2_k127_572373_52 Methyltransferase type 11 - - - 0.0000000000008959 76.0
HFD2_k127_572373_53 PFAM MCP methyltransferase CheR-type K00575 - 2.1.1.80 0.000001168 61.0
HFD2_k127_572373_54 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000002179 59.0
HFD2_k127_572373_6 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 534.0
HFD2_k127_572373_7 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008672 505.0
HFD2_k127_572373_8 glycyl-tRNA aminoacylation K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 499.0
HFD2_k127_572373_9 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 485.0
HFD2_k127_603747_0 Ftsk_gamma K03466 - - 5.773e-195 637.0
HFD2_k127_603747_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006909 350.0
HFD2_k127_603747_2 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002118 284.0
HFD2_k127_603747_3 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001509 295.0
HFD2_k127_603747_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000001443 259.0
HFD2_k127_603747_5 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000001145 246.0
HFD2_k127_603747_6 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.0000000000000000000002271 106.0
HFD2_k127_6096652_0 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 606.0
HFD2_k127_6096652_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 538.0
HFD2_k127_6096652_10 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000002405 215.0
HFD2_k127_6096652_11 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000001585 160.0
HFD2_k127_6096652_12 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000001187 120.0
HFD2_k127_6096652_13 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000002256 121.0
HFD2_k127_6096652_14 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000141 110.0
HFD2_k127_6096652_15 Ribosomal L32p protein family K02911 - - 0.000000000000000000005291 94.0
HFD2_k127_6096652_16 peptidyl-tyrosine sulfation - - - 0.000000003395 68.0
HFD2_k127_6096652_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 501.0
HFD2_k127_6096652_3 amino acid peptide transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 449.0
HFD2_k127_6096652_4 phosphoglucomutase phosphomannomutase alpha beta alpha domain II K01840 - 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 412.0
HFD2_k127_6096652_5 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 392.0
HFD2_k127_6096652_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 366.0
HFD2_k127_6096652_7 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 351.0
HFD2_k127_6096652_8 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 337.0
HFD2_k127_6096652_9 PFAM transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 311.0
HFD2_k127_6186757_0 hydrolase family 92 - - - 4.119e-303 957.0
HFD2_k127_6186757_1 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 580.0
HFD2_k127_6186757_10 Belongs to the BI1 family K06890,K19416 - - 0.000000000000000000000000000000000000000000000000000001123 200.0
HFD2_k127_6186757_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000003152 201.0
HFD2_k127_6186757_12 Peptidase, M23 family - - - 0.0000000000000000000000000000000001144 135.0
HFD2_k127_6186757_13 SET domain K07117 - - 0.0000000000000000000000000000000499 129.0
HFD2_k127_6186757_14 - - - - 0.00000000000000000000000000001018 126.0
HFD2_k127_6186757_15 Cold-Shock Protein K03704 - - 0.000000000000000000000006182 105.0
HFD2_k127_6186757_16 - - - - 0.00000000000000001698 91.0
HFD2_k127_6186757_18 protein conserved in cyanobacteria - - - 0.0000000135 62.0
HFD2_k127_6186757_2 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 558.0
HFD2_k127_6186757_3 Peptidase family M3 K01284 - 3.4.15.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 484.0
HFD2_k127_6186757_4 serine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 438.0
HFD2_k127_6186757_5 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 411.0
HFD2_k127_6186757_6 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 390.0
HFD2_k127_6186757_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 297.0
HFD2_k127_6186757_8 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001705 284.0
HFD2_k127_6186757_9 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001185 271.0
HFD2_k127_6206537_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.872e-231 728.0
HFD2_k127_6206537_1 PFAM Type II secretion system protein E K02652 - - 4.944e-217 686.0
HFD2_k127_6206537_10 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 304.0
HFD2_k127_6206537_11 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 316.0
HFD2_k127_6206537_12 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005615 276.0
HFD2_k127_6206537_13 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003884 276.0
HFD2_k127_6206537_14 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000455 254.0
HFD2_k127_6206537_15 isomerase activity K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000001016 241.0
HFD2_k127_6206537_16 Belongs to the DapA family K01714,K22397 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575 4.1.2.28,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000002153 237.0
HFD2_k127_6206537_17 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000003446 225.0
HFD2_k127_6206537_18 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000003507 219.0
HFD2_k127_6206537_19 Participates in transcription elongation, termination and antitermination - - - 0.0000000000000000000000000000000000000000000000000000000000005387 226.0
HFD2_k127_6206537_2 Carboxypeptidase regulatory-like domain - - - 3.567e-206 679.0
HFD2_k127_6206537_20 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000007714 202.0
HFD2_k127_6206537_21 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000001116 191.0
HFD2_k127_6206537_22 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000001132 183.0
HFD2_k127_6206537_23 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000396 178.0
HFD2_k127_6206537_24 Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000152 173.0
HFD2_k127_6206537_25 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000005266 165.0
HFD2_k127_6206537_26 ECF sigma factor K03088 - - 0.000000000000000000000000000000000002207 145.0
HFD2_k127_6206537_27 type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000001101 154.0
HFD2_k127_6206537_28 - - - - 0.000000000000000000000000000000005402 132.0
HFD2_k127_6206537_29 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.000000000000000000000000000000009603 136.0
HFD2_k127_6206537_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 1.542e-198 628.0
HFD2_k127_6206537_30 amine dehydrogenase activity - - - 0.00000000000000000000000000000179 132.0
HFD2_k127_6206537_31 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000001729 123.0
HFD2_k127_6206537_32 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000001503 123.0
HFD2_k127_6206537_33 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000001509 119.0
HFD2_k127_6206537_34 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.0000000000000000000000001922 109.0
HFD2_k127_6206537_35 Biotin-requiring enzyme - - - 0.000000000000000000001289 103.0
HFD2_k127_6206537_36 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000001097 64.0
HFD2_k127_6206537_37 Pilus assembly protein - - - 0.00000003295 64.0
HFD2_k127_6206537_38 Peptidase M16 inactive domain - - - 0.000004737 57.0
HFD2_k127_6206537_39 - - - - 0.0000205 50.0
HFD2_k127_6206537_4 Esterase of the alpha-beta hydrolase superfamily K07001 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 562.0
HFD2_k127_6206537_40 - - - - 0.00005667 50.0
HFD2_k127_6206537_41 Anti-sigma K factor RskA - - - 0.0001334 52.0
HFD2_k127_6206537_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 537.0
HFD2_k127_6206537_6 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 502.0
HFD2_k127_6206537_7 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 411.0
HFD2_k127_6206537_8 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 349.0
HFD2_k127_6206537_9 SPFH Band 7 PHB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 346.0
HFD2_k127_6254213_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1102.0
HFD2_k127_6254213_1 GTP-binding protein TypA K06207 - - 1.647e-260 814.0
HFD2_k127_6254213_10 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 519.0
HFD2_k127_6254213_11 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 462.0
HFD2_k127_6254213_12 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 481.0
HFD2_k127_6254213_13 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007355 445.0
HFD2_k127_6254213_14 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 425.0
HFD2_k127_6254213_15 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 420.0
HFD2_k127_6254213_16 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 433.0
HFD2_k127_6254213_17 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007045 417.0
HFD2_k127_6254213_18 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 415.0
HFD2_k127_6254213_19 response regulator receiver K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 395.0
HFD2_k127_6254213_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 9.031e-223 702.0
HFD2_k127_6254213_20 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 372.0
HFD2_k127_6254213_21 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 369.0
HFD2_k127_6254213_22 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 334.0
HFD2_k127_6254213_23 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 338.0
HFD2_k127_6254213_24 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 323.0
HFD2_k127_6254213_25 von Willebrand factor (vWF) type A domain K02448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009957 339.0
HFD2_k127_6254213_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 303.0
HFD2_k127_6254213_27 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 299.0
HFD2_k127_6254213_28 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001364 278.0
HFD2_k127_6254213_29 Protein of unknown function (DUF434) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003349 265.0
HFD2_k127_6254213_3 PFAM Alcohol dehydrogenase - - - 3.074e-204 642.0
HFD2_k127_6254213_30 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007455 267.0
HFD2_k127_6254213_31 Alpha-tubulin suppressor and related RCC1 domain-containing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000972 277.0
HFD2_k127_6254213_32 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000002433 233.0
HFD2_k127_6254213_33 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000559 226.0
HFD2_k127_6254213_34 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000009369 214.0
HFD2_k127_6254213_35 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000003629 216.0
HFD2_k127_6254213_36 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000005459 179.0
HFD2_k127_6254213_37 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000007811 160.0
HFD2_k127_6254213_38 Tricorn protease C1 domain K03797 - 3.4.21.102 0.00000000000000000000000000000000000000009496 168.0
HFD2_k127_6254213_39 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000286 149.0
HFD2_k127_6254213_4 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 5.716e-199 632.0
HFD2_k127_6254213_40 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000123 129.0
HFD2_k127_6254213_41 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000003526 113.0
HFD2_k127_6254213_42 cellulose binding - - - 0.00000000000000000000003623 117.0
HFD2_k127_6254213_43 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000003271 95.0
HFD2_k127_6254213_44 Two component transcriptional regulator, winged helix family - - - 0.000000000000000001569 91.0
HFD2_k127_6254213_45 PEP-CTERM motif - - - 0.00000000000000001884 91.0
HFD2_k127_6254213_46 domain protein K01179,K12567,K20276,K21449 - 2.7.11.1,3.2.1.4 0.000000000000004529 91.0
HFD2_k127_6254213_47 YcxB-like protein - - - 0.00000000000001915 82.0
HFD2_k127_6254213_49 Membrane - - - 0.0000000006746 67.0
HFD2_k127_6254213_5 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 598.0
HFD2_k127_6254213_50 TPR repeat-containing protein - - - 0.00000002653 66.0
HFD2_k127_6254213_51 COG3209 Rhs family protein - - - 0.00000008534 64.0
HFD2_k127_6254213_52 guanyl-nucleotide exchange factor activity K20276 - - 0.0000001141 66.0
HFD2_k127_6254213_53 Clostripain family - - - 0.0000002248 64.0
HFD2_k127_6254213_54 Pilus assembly protein K02663 - - 0.0000002904 60.0
HFD2_k127_6254213_55 peptidyl-tyrosine sulfation - - - 0.00001953 56.0
HFD2_k127_6254213_56 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00002414 55.0
HFD2_k127_6254213_57 Involved in the tonB-independent uptake of proteins - - - 0.00003869 55.0
HFD2_k127_6254213_58 general secretion pathway protein K02456,K02650 - - 0.00004703 54.0
HFD2_k127_6254213_59 Dienelactone hydrolase family - - - 0.0004192 48.0
HFD2_k127_6254213_6 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 585.0
HFD2_k127_6254213_60 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.0004342 55.0
HFD2_k127_6254213_7 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 562.0
HFD2_k127_6254213_8 Belongs to the ClpA ClpB family K03696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 516.0
HFD2_k127_6254213_9 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 495.0
HFD2_k127_6267305_0 Prolyl oligopeptidase family - - - 1.817e-256 813.0
HFD2_k127_6267305_1 Carboxypeptidase regulatory-like domain - - - 3.829e-194 650.0
HFD2_k127_6267305_2 Belongs to the glycosyl hydrolase 28 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 553.0
HFD2_k127_6267305_3 Pectic acid lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 424.0
HFD2_k127_6267305_4 Pectinesterase K01051 - 3.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000002985 286.0
HFD2_k127_6267305_5 PFAM Transglycosylase SLT domain K08309 - - 0.000000000000000000000000004634 119.0
HFD2_k127_6267305_6 PFAM Transposase IS200-like K07491 - - 0.0000001173 63.0
HFD2_k127_6267305_7 Transposase K07491 - - 0.00002673 55.0
HFD2_k127_6267305_8 Endonuclease/Exonuclease/phosphatase family - - - 0.0006684 51.0
HFD2_k127_6313200_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1322.0
HFD2_k127_6313200_1 Associated with various cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 390.0
HFD2_k127_6313200_10 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000005384 207.0
HFD2_k127_6313200_11 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.000000000000000000000000000000000000000002314 162.0
HFD2_k127_6313200_12 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000000000000000000001299 160.0
HFD2_k127_6313200_13 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000009552 156.0
HFD2_k127_6313200_14 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000006226 156.0
HFD2_k127_6313200_15 SUF system FeS assembly protein, NifU family K04488 - - 0.000000000000000000000000000000001051 134.0
HFD2_k127_6313200_16 - - - - 0.000000000000000005991 84.0
HFD2_k127_6313200_2 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 360.0
HFD2_k127_6313200_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 345.0
HFD2_k127_6313200_4 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 345.0
HFD2_k127_6313200_5 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001214 261.0
HFD2_k127_6313200_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000004528 263.0
HFD2_k127_6313200_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001159 258.0
HFD2_k127_6313200_8 COGs COG1975 Xanthine and CO dehydrogenase maturation factor XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000009524 236.0
HFD2_k127_6313200_9 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000003729 212.0
HFD2_k127_6414991_0 Carboxypeptidase regulatory-like domain - - - 0.0 1483.0
HFD2_k127_6414991_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1159.0
HFD2_k127_6414991_10 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 359.0
HFD2_k127_6414991_11 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 343.0
HFD2_k127_6414991_12 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 336.0
HFD2_k127_6414991_13 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 336.0
HFD2_k127_6414991_14 Peptidase M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 339.0
HFD2_k127_6414991_15 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 336.0
HFD2_k127_6414991_16 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 316.0
HFD2_k127_6414991_17 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 294.0
HFD2_k127_6414991_18 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K22024 - 1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 291.0
HFD2_k127_6414991_19 Peptidase M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001151 299.0
HFD2_k127_6414991_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.385e-289 913.0
HFD2_k127_6414991_20 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002203 280.0
HFD2_k127_6414991_21 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000001473 274.0
HFD2_k127_6414991_22 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002812 279.0
HFD2_k127_6414991_23 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000202 248.0
HFD2_k127_6414991_24 Phosphoribosyl transferase domain K00760,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000104 226.0
HFD2_k127_6414991_25 Pyruvate phosphate dikinase - - - 0.0000000000000000000000000000000000000000000000000000000000000008381 224.0
HFD2_k127_6414991_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000006884 222.0
HFD2_k127_6414991_27 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000000000000000003005 196.0
HFD2_k127_6414991_28 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000001677 190.0
HFD2_k127_6414991_29 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000009787 192.0
HFD2_k127_6414991_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.093e-222 720.0
HFD2_k127_6414991_30 Photosynthesis system II assembly factor YCF48 - - - 0.00000000000000000000000000000000000000000000000008727 194.0
HFD2_k127_6414991_31 PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000001343 187.0
HFD2_k127_6414991_32 - - - - 0.00000000000000000000000000000000000000000000007894 177.0
HFD2_k127_6414991_33 Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000001052 164.0
HFD2_k127_6414991_34 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.000000000000000000000000000000000000001623 153.0
HFD2_k127_6414991_35 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000001889 157.0
HFD2_k127_6414991_36 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000009155 149.0
HFD2_k127_6414991_37 - - - - 0.000000000000000000000000000000000001477 149.0
HFD2_k127_6414991_38 response regulator - - - 0.0000000000000000000000000000000000195 150.0
HFD2_k127_6414991_39 Protein of unknown function (DUF962) - - - 0.0000000000000000000000000000000001035 135.0
HFD2_k127_6414991_4 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007256 553.0
HFD2_k127_6414991_40 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000002381 138.0
HFD2_k127_6414991_41 Yqey-like protein K09117 - - 0.0000000000000000000000000000000004276 137.0
HFD2_k127_6414991_42 Tetratricopeptide repeat - - - 0.000000000000000000000000000000001545 139.0
HFD2_k127_6414991_43 metallopeptidase activity - - - 0.000000000000000000000000000000815 132.0
HFD2_k127_6414991_44 Zn peptidase K21686 - - 0.0000000000000000000000006964 111.0
HFD2_k127_6414991_45 Xanthine and CO dehydrogenases maturation factor XdhC CoxF K07402 - - 0.00000000000000000000001755 104.0
HFD2_k127_6414991_46 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000008956 111.0
HFD2_k127_6414991_47 Penicillinase repressor - - - 0.000000000000000000000115 103.0
HFD2_k127_6414991_48 Hfq protein - - - 0.0000000000000000000001932 101.0
HFD2_k127_6414991_49 iron ion homeostasis - - - 0.00000000000000000000038 109.0
HFD2_k127_6414991_5 Vault protein inter-alpha-trypsin domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005255 507.0
HFD2_k127_6414991_50 methyltransferase - - - 0.0000000000000000003045 98.0
HFD2_k127_6414991_51 von Willebrand factor, type A - - - 0.000000000000000006025 96.0
HFD2_k127_6414991_52 PFAM regulatory protein GntR HTH K07979 - - 0.00000000000000001685 87.0
HFD2_k127_6414991_53 7TM diverse intracellular signalling - - - 0.0000000000000008844 82.0
HFD2_k127_6414991_54 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000001979 81.0
HFD2_k127_6414991_55 - - - - 0.00000000000002628 76.0
HFD2_k127_6414991_56 C-3'',4'' desaturase CrtD - - - 0.00000000000002862 85.0
HFD2_k127_6414991_57 TonB dependent receptor K16087 - - 0.00000000000004856 87.0
HFD2_k127_6414991_59 - - - - 0.000000000004366 74.0
HFD2_k127_6414991_6 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 476.0
HFD2_k127_6414991_60 oxidoreductase activity K12511 - - 0.0000000007008 72.0
HFD2_k127_6414991_61 sequence-specific DNA binding - - - 0.00009933 52.0
HFD2_k127_6414991_62 rhs family - - - 0.0001157 47.0
HFD2_k127_6414991_63 PFAM Abortive infection protein K07052 - - 0.0001936 52.0
HFD2_k127_6414991_64 peptidase M48, Ste24p - - - 0.000224 53.0
HFD2_k127_6414991_65 Type II secretion system (T2SS), protein G K02456 - - 0.0007129 51.0
HFD2_k127_6414991_7 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 462.0
HFD2_k127_6414991_8 Vault protein inter-alpha-trypsin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 448.0
HFD2_k127_6414991_9 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 381.0
HFD2_k127_6557877_0 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 398.0
HFD2_k127_6557877_1 Belongs to the CinA family K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 396.0
HFD2_k127_6557877_10 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.00000000000000000001436 92.0
HFD2_k127_6557877_11 - - - - 0.00000000000000000189 89.0
HFD2_k127_6557877_12 Universal stress protein family - - - 0.000000000000006917 81.0
HFD2_k127_6557877_13 transcriptional regulator K07727 - - 0.000000000005518 72.0
HFD2_k127_6557877_14 Domain of unknown function (DUF4445) - - - 0.000000001012 66.0
HFD2_k127_6557877_15 phosphorelay signal transduction system - - - 0.00001245 54.0
HFD2_k127_6557877_16 - - - - 0.00002533 48.0
HFD2_k127_6557877_2 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 385.0
HFD2_k127_6557877_3 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 294.0
HFD2_k127_6557877_4 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000003529 165.0
HFD2_k127_6557877_5 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000004704 162.0
HFD2_k127_6557877_6 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000003821 150.0
HFD2_k127_6557877_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000006065 139.0
HFD2_k127_6557877_8 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.00000000000000000000003937 103.0
HFD2_k127_6557877_9 PFAM BNR Asp-box repeat - - - 0.00000000000000000000004846 102.0
HFD2_k127_6574070_0 COGs COG2192 carbamoyl transferase NodU family K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005466 612.0
HFD2_k127_6574070_1 ADP-glyceromanno-heptose 6-epimerase activity K01710,K01784,K08678,K08679 - 4.1.1.35,4.2.1.46,5.1.3.2,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 515.0
HFD2_k127_6574070_10 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 321.0
HFD2_k127_6574070_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008217 292.0
HFD2_k127_6574070_12 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001092 277.0
HFD2_k127_6574070_13 Glycosyl transferase family 4 K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000003629 269.0
HFD2_k127_6574070_14 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001327 249.0
HFD2_k127_6574070_15 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000002481 252.0
HFD2_k127_6574070_16 Tellurite resistance protein TehB K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000001588 190.0
HFD2_k127_6574070_17 O-Antigen ligase K02847 - - 0.00000000000000000000000000000002274 141.0
HFD2_k127_6574070_18 3-demethylubiquinone-9 3-O-methyltransferase activity K15257 - - 0.0000000000000000000000000005849 124.0
HFD2_k127_6574070_19 Capsular exopolysaccharide family K16554 - - 0.0000000000000000002788 90.0
HFD2_k127_6574070_2 ADP-glyceromanno-heptose 6-epimerase activity K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 510.0
HFD2_k127_6574070_20 Glycosyl transferases group 1 - - - 0.0000000008367 70.0
HFD2_k127_6574070_21 Glycosyltransferase like family 2 K07011,K20444 - - 0.00000001786 66.0
HFD2_k127_6574070_22 lipolytic protein G-D-S-L family K19172 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000008563 57.0
HFD2_k127_6574070_3 asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 451.0
HFD2_k127_6574070_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 411.0
HFD2_k127_6574070_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 407.0
HFD2_k127_6574070_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 384.0
HFD2_k127_6574070_7 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 385.0
HFD2_k127_6574070_8 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 362.0
HFD2_k127_6574070_9 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 336.0
HFD2_k127_661654_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.07e-301 946.0
HFD2_k127_661654_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 7.576e-214 687.0
HFD2_k127_661654_10 - - - - 0.000000000007103 75.0
HFD2_k127_661654_11 Domain of unknown function (DUF4956) - - - 0.000000004329 68.0
HFD2_k127_661654_12 Tyrosine phosphatase family - - - 0.00001411 55.0
HFD2_k127_661654_13 Putative zinc-finger - - - 0.0001549 52.0
HFD2_k127_661654_2 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 553.0
HFD2_k127_661654_3 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000038 274.0
HFD2_k127_661654_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000003523 223.0
HFD2_k127_661654_5 - - - - 0.000000000000000000000000000000000000000000000000000005717 202.0
HFD2_k127_661654_6 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000002494 176.0
HFD2_k127_661654_7 Peptidase family M23 - - - 0.00000000000000000000000000000000000008522 154.0
HFD2_k127_661654_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000007252 89.0
HFD2_k127_661654_9 CS domain K13993 - - 0.000000000002635 73.0
HFD2_k127_6644866_0 TIGRFAM carbamoyl-phosphate synthase, large subunit K01955 - 6.3.5.5 0.0 1397.0
HFD2_k127_6644866_1 Carboxypeptidase regulatory-like domain - - - 6.717e-315 1003.0
HFD2_k127_6644866_10 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000000004855 204.0
HFD2_k127_6644866_11 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000002191 186.0
HFD2_k127_6644866_12 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000008496 179.0
HFD2_k127_6644866_13 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000002872 179.0
HFD2_k127_6644866_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000001036 177.0
HFD2_k127_6644866_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.0000000000000000000000000000000000000000000006076 171.0
HFD2_k127_6644866_16 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000769 172.0
HFD2_k127_6644866_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000946 132.0
HFD2_k127_6644866_18 - - - - 0.00000000000000000001072 96.0
HFD2_k127_6644866_19 DoxX K15977 - - 0.00000000000000005732 86.0
HFD2_k127_6644866_2 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 422.0
HFD2_k127_6644866_20 DnaJ molecular chaperone homology domain - - - 0.000000000000003089 84.0
HFD2_k127_6644866_21 Periplasmic or secreted lipoprotein - - - 0.0000000000001163 79.0
HFD2_k127_6644866_22 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.000000000173 66.0
HFD2_k127_6644866_23 - - - - 0.0000000007959 72.0
HFD2_k127_6644866_24 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07776 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141 - 0.000007319 55.0
HFD2_k127_6644866_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 346.0
HFD2_k127_6644866_4 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 342.0
HFD2_k127_6644866_5 Phosphate transport system permease protein PstA K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009552 289.0
HFD2_k127_6644866_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003352 262.0
HFD2_k127_6644866_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000002896 231.0
HFD2_k127_6644866_8 IstB-like ATP binding protein K02315 - - 0.00000000000000000000000000000000000000000000000000000003281 205.0
HFD2_k127_6644866_9 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.0000000000000000000000000000000000000000000000000000002238 201.0
HFD2_k127_6650281_0 Glycosyl hydrolase family 1 K00067 - 1.1.1.133 5.955e-298 930.0
HFD2_k127_6650281_1 Belongs to the glycosyl hydrolase 2 family - - - 3.647e-254 796.0
HFD2_k127_6650281_2 PFAM UDP-galactopyranose mutase, C-terminal K01854 - 5.4.99.9 2.483e-205 644.0
HFD2_k127_6650281_3 Uncharacterized conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000002552 211.0
HFD2_k127_6650281_4 PFAM Tetratricopeptide repeat - - - 0.00006473 53.0
HFD2_k127_69089_0 cellulose binding - - - 0.0 1050.0
HFD2_k127_69089_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.054e-205 645.0
HFD2_k127_69089_10 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 404.0
HFD2_k127_69089_11 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 381.0
HFD2_k127_69089_12 TAP-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009699 364.0
HFD2_k127_69089_13 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 305.0
HFD2_k127_69089_14 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 316.0
HFD2_k127_69089_15 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 302.0
HFD2_k127_69089_16 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 299.0
HFD2_k127_69089_17 Arginase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 292.0
HFD2_k127_69089_18 Chlorite dismutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008517 281.0
HFD2_k127_69089_19 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001403 277.0
HFD2_k127_69089_2 Sulfate permease family K01673,K03321 - 4.2.1.1 5.204e-199 634.0
HFD2_k127_69089_20 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006664 276.0
HFD2_k127_69089_21 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003123 271.0
HFD2_k127_69089_22 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000007068 258.0
HFD2_k127_69089_23 Domain of unknown function (DUF3488) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002229 280.0
HFD2_k127_69089_24 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000002238 247.0
HFD2_k127_69089_25 Serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000136 239.0
HFD2_k127_69089_26 Membrane - - - 0.000000000000000000000000000000000000000000000000006359 203.0
HFD2_k127_69089_27 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000001069 177.0
HFD2_k127_69089_28 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.0000000000000000000000000000000000000000003086 175.0
HFD2_k127_69089_29 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000003065 161.0
HFD2_k127_69089_3 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 530.0
HFD2_k127_69089_30 - - - - 0.00000000000000000000000000000000000000004149 167.0
HFD2_k127_69089_31 oxidoreductase activity - - - 0.00000000000000000000000000000000001702 156.0
HFD2_k127_69089_32 peptidyl-prolyl cis-trans isomerase K03772,K03773 - 5.2.1.8 0.000000000000000000000000000000001144 136.0
HFD2_k127_69089_33 Sigma-70, region 4 - - - 0.000000000000000000000000000001499 128.0
HFD2_k127_69089_34 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K08641,K11206 - 3.4.13.22 0.000000000000000000000000003894 111.0
HFD2_k127_69089_35 Rieske [2Fe-2S] domain K03886 - - 0.00000000000000000000000006705 113.0
HFD2_k127_69089_36 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000001561 106.0
HFD2_k127_69089_37 cheY-homologous receiver domain - - - 0.00000000000000000000005398 102.0
HFD2_k127_69089_38 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.00000000000000000000009373 106.0
HFD2_k127_69089_39 acylphosphatase activity K01512 - 3.6.1.7 0.000000000000004185 79.0
HFD2_k127_69089_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 524.0
HFD2_k127_69089_40 Pilus assembly protein PilX K02673 - - 0.0000000000002156 83.0
HFD2_k127_69089_41 transmembrane transporter activity - - - 0.00000000004353 69.0
HFD2_k127_69089_42 - - - - 0.000003531 54.0
HFD2_k127_69089_43 ATP-independent chaperone mediated protein folding K06006 - - 0.00002261 55.0
HFD2_k127_69089_45 Cytochrome c K00406,K08906 - - 0.00004207 51.0
HFD2_k127_69089_46 Beta-galactosidase K12308 - 3.2.1.23 0.00007805 56.0
HFD2_k127_69089_47 - - - - 0.00008059 54.0
HFD2_k127_69089_48 pilus assembly protein PilW K02672 - - 0.0001255 52.0
HFD2_k127_69089_5 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 471.0
HFD2_k127_69089_6 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 465.0
HFD2_k127_69089_7 AAA ATPase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 454.0
HFD2_k127_69089_8 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 417.0
HFD2_k127_69089_9 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 423.0
HFD2_k127_699389_0 Tricorn protease homolog - - - 0.0 1339.0
HFD2_k127_699389_1 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1287.0
HFD2_k127_699389_10 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000001625 220.0
HFD2_k127_699389_11 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000933 203.0
HFD2_k127_699389_12 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000000000001305 189.0
HFD2_k127_699389_13 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000003947 194.0
HFD2_k127_699389_14 Helix-turn-helix domain K03088 - - 0.00000000000000000000000000000266 127.0
HFD2_k127_699389_15 TPR repeat - - - 0.0000000000000000000002137 103.0
HFD2_k127_699389_16 - - - - 0.0000000003827 66.0
HFD2_k127_699389_17 - - - - 0.000009213 52.0
HFD2_k127_699389_2 Belongs to the aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 5.514e-198 632.0
HFD2_k127_699389_3 Belongs to the aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 586.0
HFD2_k127_699389_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 490.0
HFD2_k127_699389_5 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 408.0
HFD2_k127_699389_6 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 300.0
HFD2_k127_699389_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001847 255.0
HFD2_k127_699389_8 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002 251.0
HFD2_k127_699389_9 Belongs to the MlaE permease family K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000396 237.0
HFD2_k127_7051947_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 9.923e-281 908.0
HFD2_k127_7051947_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 423.0
HFD2_k127_7051947_10 oxidoreductase activity - - - 0.000000000000000000000000000000000002039 157.0
HFD2_k127_7051947_11 outer membrane efflux protein - - - 0.0000000000000000000000000000000002559 148.0
HFD2_k127_7051947_12 - - - - 0.000000000000000000000000000136 117.0
HFD2_k127_7051947_13 beta-propeller repeat - - - 0.0000000000000000000000001364 109.0
HFD2_k127_7051947_14 DinB family - - - 0.0000000000000000000000001595 112.0
HFD2_k127_7051947_15 Tyrosine phosphatase family - - - 0.000000000000000000005732 100.0
HFD2_k127_7051947_16 AntiSigma factor - - - 0.000000000000000000502 97.0
HFD2_k127_7051947_17 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.0000000001828 65.0
HFD2_k127_7051947_18 PFAM SMP-30 Gluconolaconase K01053 - 3.1.1.17 0.0000003453 60.0
HFD2_k127_7051947_19 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.00009233 54.0
HFD2_k127_7051947_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 312.0
HFD2_k127_7051947_3 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002003 277.0
HFD2_k127_7051947_4 MOSC N-terminal beta barrel domain K07140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002381 261.0
HFD2_k127_7051947_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000002929 231.0
HFD2_k127_7051947_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000003273 161.0
HFD2_k127_7051947_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000275 169.0
HFD2_k127_7051947_8 methylamine metabolic process K15977 - - 0.0000000000000000000000000000000000000003644 158.0
HFD2_k127_7051947_9 TIR domain - - - 0.00000000000000000000000000000000000000307 159.0
HFD2_k127_7140752_0 Vault protein inter-alpha-trypsin domain K07114 - - 3.017e-194 634.0
HFD2_k127_7140752_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 389.0
HFD2_k127_7140752_10 Recombinase zinc beta ribbon domain - - - 0.00000000000000000000000000000000007885 147.0
HFD2_k127_7140752_11 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000000003897 115.0
HFD2_k127_7140752_2 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 378.0
HFD2_k127_7140752_3 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 364.0
HFD2_k127_7140752_4 PFAM peptidase K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 324.0
HFD2_k127_7140752_5 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 321.0
HFD2_k127_7140752_6 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001063 287.0
HFD2_k127_7140752_7 PFAM Aminotransferase, class I K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000008131 256.0
HFD2_k127_7140752_8 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000008112 192.0
HFD2_k127_7140752_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000004502 169.0
HFD2_k127_7170322_0 Carboxyl transferase domain - - - 6.689e-236 743.0
HFD2_k127_7170322_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.481e-222 706.0
HFD2_k127_7170322_10 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009337 500.0
HFD2_k127_7170322_11 COG0635 Coproporphyrinogen III oxidase and related Fe-S - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 497.0
HFD2_k127_7170322_12 amino acid peptide transporter K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 486.0
HFD2_k127_7170322_13 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 470.0
HFD2_k127_7170322_14 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 460.0
HFD2_k127_7170322_15 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 471.0
HFD2_k127_7170322_16 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 430.0
HFD2_k127_7170322_17 COG0644 Dehydrogenases (flavoproteins) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 417.0
HFD2_k127_7170322_18 Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 406.0
HFD2_k127_7170322_19 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 384.0
HFD2_k127_7170322_2 Tetratricopeptide repeat - - - 1.274e-220 721.0
HFD2_k127_7170322_20 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 376.0
HFD2_k127_7170322_21 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 370.0
HFD2_k127_7170322_22 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 371.0
HFD2_k127_7170322_23 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 361.0
HFD2_k127_7170322_24 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 359.0
HFD2_k127_7170322_25 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 357.0
HFD2_k127_7170322_26 PFAM Peptidase M1 membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 348.0
HFD2_k127_7170322_27 beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 339.0
HFD2_k127_7170322_28 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 336.0
HFD2_k127_7170322_29 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 324.0
HFD2_k127_7170322_3 FtsX-like permease family - - - 2.615e-214 709.0
HFD2_k127_7170322_30 protein kinase related protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 310.0
HFD2_k127_7170322_31 PFAM Metallophosphoesterase K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 287.0
HFD2_k127_7170322_32 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000009134 284.0
HFD2_k127_7170322_33 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002931 276.0
HFD2_k127_7170322_34 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000318 293.0
HFD2_k127_7170322_35 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K02003,K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004346 255.0
HFD2_k127_7170322_36 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000002325 222.0
HFD2_k127_7170322_37 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000000000000000437 215.0
HFD2_k127_7170322_38 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000000000000001768 222.0
HFD2_k127_7170322_39 RNA polymerase, sigma-24 subunit, ECF subfamily K02405 - - 0.00000000000000000000000000000000000000000000000000000000009073 209.0
HFD2_k127_7170322_4 Bacterial protein of unknown function (DUF885) - - - 5.012e-204 653.0
HFD2_k127_7170322_40 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000003534 205.0
HFD2_k127_7170322_41 Ferritin-like domain - - - 0.000000000000000000000000000000000000000000000000000000004272 203.0
HFD2_k127_7170322_42 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000005776 200.0
HFD2_k127_7170322_43 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000006276 178.0
HFD2_k127_7170322_44 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000008244 161.0
HFD2_k127_7170322_45 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000001224 153.0
HFD2_k127_7170322_46 PFAM thioesterase superfamily K07107 - - 0.0000000000000000000000000000000000001933 147.0
HFD2_k127_7170322_47 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000001664 139.0
HFD2_k127_7170322_48 Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000001751 127.0
HFD2_k127_7170322_49 von Willebrand factor, type A K07114,K12511 - - 0.00000000000000000000000001189 124.0
HFD2_k127_7170322_5 siderophore transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 593.0
HFD2_k127_7170322_50 - - - - 0.00000000000000000000000009793 112.0
HFD2_k127_7170322_51 TIR domain - - - 0.00000000000000000000000185 115.0
HFD2_k127_7170322_52 IMP dehydrogenase activity - - - 0.00000000000000000000001605 109.0
HFD2_k127_7170322_53 - - - - 0.000000000000000000009627 103.0
HFD2_k127_7170322_54 Phage integrase, N-terminal SAM-like domain K14059 - - 0.00000000000000000001041 95.0
HFD2_k127_7170322_56 ATPase family associated with various cellular activities (AAA) K10943 - - 0.0000000000000000009509 93.0
HFD2_k127_7170322_57 Ribosomal protein L35 K02916 - - 0.000000000000000004059 85.0
HFD2_k127_7170322_58 acetyltransferase K06976 - - 0.0000000000000001856 91.0
HFD2_k127_7170322_59 - - - - 0.00000000000006527 74.0
HFD2_k127_7170322_6 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 562.0
HFD2_k127_7170322_60 Protein of unknown function (DUF3311) - - - 0.000000000000129 73.0
HFD2_k127_7170322_61 Protein of unknown function (DUF433) - - - 0.000000000002195 72.0
HFD2_k127_7170322_62 Hypothetical methyltransferase - - - 0.00000000001029 73.0
HFD2_k127_7170322_63 Tetratricopeptide repeat K09527 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0030544,GO:0031072,GO:0051084,GO:0051085,GO:0061077 - 0.00000000002712 73.0
HFD2_k127_7170322_64 ankyrin repeat - - - 0.0000000000525 73.0
HFD2_k127_7170322_65 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000009774 59.0
HFD2_k127_7170322_66 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000005418 56.0
HFD2_k127_7170322_68 - - - - 0.0002789 50.0
HFD2_k127_7170322_69 PFAM Bacterial transferase hexapeptide (three repeats) K13018 - 2.3.1.201 0.0006281 49.0
HFD2_k127_7170322_7 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 538.0
HFD2_k127_7170322_8 protein kinase related protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 535.0
HFD2_k127_7170322_9 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 512.0
HFD2_k127_7170338_0 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 480.0
HFD2_k127_7170338_1 membrane protein, TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008161 399.0
HFD2_k127_7170338_10 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000006938 177.0
HFD2_k127_7170338_11 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000000000000000002699 104.0
HFD2_k127_7170338_12 NfeD-like C-terminal, partner-binding - - - 0.00000000000000001084 89.0
HFD2_k127_7170338_13 - - - - 0.0001283 47.0
HFD2_k127_7170338_2 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 389.0
HFD2_k127_7170338_3 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 372.0
HFD2_k127_7170338_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 374.0
HFD2_k127_7170338_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009625 299.0
HFD2_k127_7170338_6 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000001589 233.0
HFD2_k127_7170338_7 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000001785 229.0
HFD2_k127_7170338_8 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000007821 213.0
HFD2_k127_7170338_9 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000003882 200.0
HFD2_k127_7353401_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1323.0
HFD2_k127_7353401_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.569e-294 925.0
HFD2_k127_7353401_2 Peptidase family M28 - - - 5.279e-209 666.0
HFD2_k127_7353401_3 AcrB/AcrD/AcrF family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 321.0
HFD2_k127_7353401_4 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000267 287.0
HFD2_k127_7353401_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004169 256.0
HFD2_k127_7353401_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000001137 234.0
HFD2_k127_7353401_7 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000001835 170.0
HFD2_k127_7353401_8 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000359 49.0
HFD2_k127_7404029_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 573.0
HFD2_k127_7404029_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 563.0
HFD2_k127_7404029_10 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000003587 226.0
HFD2_k127_7404029_11 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000264 221.0
HFD2_k127_7404029_12 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000006236 208.0
HFD2_k127_7404029_13 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000001292 180.0
HFD2_k127_7404029_14 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000431 174.0
HFD2_k127_7404029_15 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000004514 144.0
HFD2_k127_7404029_16 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000000004518 139.0
HFD2_k127_7404029_17 Methyltransferase domain - - - 0.00000000000000000000000000357 121.0
HFD2_k127_7404029_18 Histidine kinase - - - 0.0000000000000000000000001039 110.0
HFD2_k127_7404029_19 Probable zinc-ribbon domain - - - 0.000000000000000000001242 98.0
HFD2_k127_7404029_2 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 557.0
HFD2_k127_7404029_20 Bacterial regulatory protein, Fis family K02481,K02667 - - 0.000000000001748 75.0
HFD2_k127_7404029_21 Amidohydrolase family - - - 0.000000000003024 66.0
HFD2_k127_7404029_22 PFAM D12 class N6 adenine-specific DNA methyltransferase K07318 - 2.1.1.72 0.0000000001278 72.0
HFD2_k127_7404029_23 - - - - 0.000215 44.0
HFD2_k127_7404029_24 ABC transporter, ATP-binding protein K06147 - - 0.0005221 45.0
HFD2_k127_7404029_25 nuclease - - - 0.0006958 50.0
HFD2_k127_7404029_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 430.0
HFD2_k127_7404029_4 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 382.0
HFD2_k127_7404029_5 Forkhead associated domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 341.0
HFD2_k127_7404029_6 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009516 319.0
HFD2_k127_7404029_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 309.0
HFD2_k127_7404029_8 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004223 284.0
HFD2_k127_7404029_9 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000178 271.0
HFD2_k127_7414752_0 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 551.0
HFD2_k127_7414752_1 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 399.0
HFD2_k127_7414752_2 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 355.0
HFD2_k127_7414752_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000001536 184.0
HFD2_k127_7414752_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000003963 175.0
HFD2_k127_7414752_5 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000004545 134.0
HFD2_k127_7414752_6 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.00000000000000000005678 105.0
HFD2_k127_7414752_7 shape-determining protein MreD K03571 - - 0.00005983 53.0
HFD2_k127_7414752_8 FecR protein - - - 0.0009477 51.0
HFD2_k127_7466110_0 Tricorn protease homolog K08676 - - 0.0 1500.0
HFD2_k127_7466110_1 Peptidase M61 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 503.0
HFD2_k127_7466110_10 Glycosyltransferase Family 4 - - - 0.000000000000000005317 96.0
HFD2_k127_7466110_11 Polymer-forming cytoskeletal - - - 0.0000002918 57.0
HFD2_k127_7466110_2 MFS_1 like family K08151,K08153 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002067 287.0
HFD2_k127_7466110_3 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000009388 263.0
HFD2_k127_7466110_4 Enoyl-CoA hydratase/isomerase K01715,K13767 GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000001827 230.0
HFD2_k127_7466110_5 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000008134 190.0
HFD2_k127_7466110_6 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000229 140.0
HFD2_k127_7466110_7 triphosphatase activity - - - 0.00000000000000000000000354 109.0
HFD2_k127_7466110_8 Protein of unknown function (DUF3298) - - - 0.00000000000000000000003095 113.0
HFD2_k127_7466110_9 DoxX K15977 - - 0.000000000000000000003052 98.0
HFD2_k127_7534144_0 cellulose binding - - - 7.512e-219 683.0
HFD2_k127_7534144_1 Conserved protein K09704 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 574.0
HFD2_k127_7534144_2 ABC transporter K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 355.0
HFD2_k127_7534144_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 341.0
HFD2_k127_7534144_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 310.0
HFD2_k127_7534144_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000001338 244.0
HFD2_k127_7534144_6 GrpB protein - - - 0.0000000000000000000000000000000000000000000000007798 177.0
HFD2_k127_7534144_7 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000000000000000000002511 148.0
HFD2_k127_7534144_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000008534 76.0
HFD2_k127_7534144_9 HEAT repeats - - - 0.000009661 58.0
HFD2_k127_7586418_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0 1351.0
HFD2_k127_7586418_1 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1318.0
HFD2_k127_7586418_10 ASPIC and UnbV - - - 4.82e-200 639.0
HFD2_k127_7586418_11 PFAM Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 6.932e-197 624.0
HFD2_k127_7586418_12 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 603.0
HFD2_k127_7586418_13 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 621.0
HFD2_k127_7586418_14 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 614.0
HFD2_k127_7586418_15 Bacterial regulatory protein, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 556.0
HFD2_k127_7586418_16 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 553.0
HFD2_k127_7586418_17 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 584.0
HFD2_k127_7586418_18 DNA polymerase beta thumb K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 540.0
HFD2_k127_7586418_19 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 477.0
HFD2_k127_7586418_2 domain protein - - - 0.0 1103.0
HFD2_k127_7586418_20 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 479.0
HFD2_k127_7586418_21 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 472.0
HFD2_k127_7586418_22 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 453.0
HFD2_k127_7586418_23 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 451.0
HFD2_k127_7586418_24 PFAM Beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 463.0
HFD2_k127_7586418_25 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 431.0
HFD2_k127_7586418_26 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 404.0
HFD2_k127_7586418_27 Putative serine dehydratase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 400.0
HFD2_k127_7586418_28 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 381.0
HFD2_k127_7586418_29 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 369.0
HFD2_k127_7586418_3 peroxiredoxin activity - - - 1.741e-301 934.0
HFD2_k127_7586418_30 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 373.0
HFD2_k127_7586418_31 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 367.0
HFD2_k127_7586418_32 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 372.0
HFD2_k127_7586418_33 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 372.0
HFD2_k127_7586418_34 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 344.0
HFD2_k127_7586418_35 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 332.0
HFD2_k127_7586418_36 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 334.0
HFD2_k127_7586418_37 PAS domain containing protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 335.0
HFD2_k127_7586418_38 beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 317.0
HFD2_k127_7586418_39 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 306.0
HFD2_k127_7586418_4 PFAM Glycosyl hydrolase family 3 C terminal domain - - - 3.82e-261 826.0
HFD2_k127_7586418_40 YdjC-like protein K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 294.0
HFD2_k127_7586418_41 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 285.0
HFD2_k127_7586418_42 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003636 276.0
HFD2_k127_7586418_43 enzyme related to lactoylglutathione lyase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003149 273.0
HFD2_k127_7586418_44 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006931 266.0
HFD2_k127_7586418_45 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001269 258.0
HFD2_k127_7586418_46 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000003661 267.0
HFD2_k127_7586418_47 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000001008 230.0
HFD2_k127_7586418_48 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000000000000000000000002255 242.0
HFD2_k127_7586418_49 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000003606 213.0
HFD2_k127_7586418_5 Carboxypeptidase regulatory-like domain - - - 4.921e-247 799.0
HFD2_k127_7586418_50 phosphoserine phosphatase activity K07315,K16928 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000001639 215.0
HFD2_k127_7586418_51 - - - - 0.00000000000000000000000000000000000000000000000000000000005964 213.0
HFD2_k127_7586418_52 ROK family - - - 0.0000000000000000000000000000000000000000000000000000000001066 219.0
HFD2_k127_7586418_53 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000008447 205.0
HFD2_k127_7586418_54 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000009232 188.0
HFD2_k127_7586418_55 EamA-like transporter family K07790 - - 0.0000000000000000000000000000000000000000000000000008113 194.0
HFD2_k127_7586418_56 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000000000000005495 184.0
HFD2_k127_7586418_57 recA bacterial DNA recombination protein - - - 0.0000000000000000000000000000000000000000000000000072 190.0
HFD2_k127_7586418_58 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000007922 188.0
HFD2_k127_7586418_59 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.00000000000000000000000000000000000000000000000002571 187.0
HFD2_k127_7586418_6 ASPIC and UnbV - - - 3.094e-245 770.0
HFD2_k127_7586418_60 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000005904 201.0
HFD2_k127_7586418_61 mannose-6-phosphate isomerase K01809,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000001801 152.0
HFD2_k127_7586418_62 - - - - 0.000000000000000000000000000000000000002166 149.0
HFD2_k127_7586418_63 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000003142 169.0
HFD2_k127_7586418_64 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000001173 152.0
HFD2_k127_7586418_65 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000003879 137.0
HFD2_k127_7586418_66 hydroperoxide reductase activity K01607 - 4.1.1.44 0.000000000000000000000000000000000704 132.0
HFD2_k127_7586418_67 glyoxalase III activity - - - 0.0000000000000000000000000009785 116.0
HFD2_k127_7586418_68 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000003705 114.0
HFD2_k127_7586418_69 transmembrane transporter activity - - - 0.0000000000000000000000002516 106.0
HFD2_k127_7586418_7 Putative carbohydrate binding domain K12373 - 3.2.1.52 1.765e-237 752.0
HFD2_k127_7586418_70 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000009864 121.0
HFD2_k127_7586418_71 Domain of unknown function (DUF4440) - - - 0.0000000000000000005462 92.0
HFD2_k127_7586418_72 Transglutaminase-like superfamily - - - 0.0000000000000000009045 95.0
HFD2_k127_7586418_74 FAD binding domain - - - 0.00000000000004158 74.0
HFD2_k127_7586418_75 sequence-specific DNA binding - - - 0.00000000000006104 82.0
HFD2_k127_7586418_76 Redoxin - - - 0.0000000000001147 75.0
HFD2_k127_7586418_77 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02667 - - 0.000000000000243 78.0
HFD2_k127_7586418_78 - - - - 0.00000000001777 74.0
HFD2_k127_7586418_79 sequence-specific DNA binding - - - 0.00000000002139 72.0
HFD2_k127_7586418_8 ASPIC and UnbV - - - 6.774e-222 700.0
HFD2_k127_7586418_81 PEP-CTERM motif - - - 0.00000007842 62.0
HFD2_k127_7586418_82 Tetratricopeptide repeat - - - 0.0000001002 64.0
HFD2_k127_7586418_83 transcriptional regulator - - - 0.00001841 52.0
HFD2_k127_7586418_87 Cytochrome c554 and c-prime - - - 0.0005888 46.0
HFD2_k127_7586418_88 IrrE N-terminal-like domain - - - 0.00062 50.0
HFD2_k127_7586418_89 alkyl hydroperoxide reductase - - - 0.0009716 48.0
HFD2_k127_7586418_9 MatE - - - 8.44e-218 684.0
HFD2_k127_7776425_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 2.287e-257 807.0
HFD2_k127_7776425_1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 501.0
HFD2_k127_7776425_11 cellulase activity - - - 0.0000000000000000004315 102.0
HFD2_k127_7776425_12 Outer membrane protein (OmpH-like) K06142 - - 0.00000001823 63.0
HFD2_k127_7776425_13 Domain of unknown function (DUF4132) - - - 0.0003598 53.0
HFD2_k127_7776425_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 463.0
HFD2_k127_7776425_3 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 462.0
HFD2_k127_7776425_4 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 322.0
HFD2_k127_7776425_5 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 297.0
HFD2_k127_7776425_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000003628 198.0
HFD2_k127_7776425_7 DinB family - - - 0.000000000000000000000000000000000000000000000000556 180.0
HFD2_k127_7776425_8 Cupin domain - - - 0.0000000000000000000000000000000000000000000000008892 177.0
HFD2_k127_7776425_9 serine-type endopeptidase activity K14645,K20276 - - 0.00000000000000000000000000000004854 135.0
HFD2_k127_7793602_0 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 367.0
HFD2_k127_7793602_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001481 297.0
HFD2_k127_7831348_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.647e-294 925.0
HFD2_k127_7831348_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 6.878e-236 739.0
HFD2_k127_7831348_10 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 446.0
HFD2_k127_7831348_11 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 423.0
HFD2_k127_7831348_12 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 426.0
HFD2_k127_7831348_13 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 382.0
HFD2_k127_7831348_14 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005343 385.0
HFD2_k127_7831348_15 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 381.0
HFD2_k127_7831348_16 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 359.0
HFD2_k127_7831348_17 AMMECR1 K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 347.0
HFD2_k127_7831348_18 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 326.0
HFD2_k127_7831348_19 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 326.0
HFD2_k127_7831348_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 1.357e-214 683.0
HFD2_k127_7831348_20 M1 (1,4-beta-N-acetylmuramidase) K07273 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 298.0
HFD2_k127_7831348_21 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 303.0
HFD2_k127_7831348_22 Sporulation initiation inhibitor protein Soj K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 297.0
HFD2_k127_7831348_23 Oxidoreductase, molybdopterin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 287.0
HFD2_k127_7831348_24 Enoyl-CoA hydratase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000159 279.0
HFD2_k127_7831348_25 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009449 279.0
HFD2_k127_7831348_26 TIR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002284 265.0
HFD2_k127_7831348_27 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002255 259.0
HFD2_k127_7831348_28 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000004366 246.0
HFD2_k127_7831348_29 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002632 243.0
HFD2_k127_7831348_3 Carboxypeptidase regulatory-like domain - - - 3.885e-213 702.0
HFD2_k127_7831348_30 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000001247 227.0
HFD2_k127_7831348_31 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000005229 227.0
HFD2_k127_7831348_32 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000003946 216.0
HFD2_k127_7831348_33 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000006786 205.0
HFD2_k127_7831348_34 DSBA-like thioredoxin domain K21990 - - 0.00000000000000000000000000000000000016 151.0
HFD2_k127_7831348_35 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000000000002504 111.0
HFD2_k127_7831348_36 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000001301 113.0
HFD2_k127_7831348_37 Jag_N K06346 - - 0.00000000000000000000001007 106.0
HFD2_k127_7831348_38 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000001276 100.0
HFD2_k127_7831348_39 Thioesterase superfamily K07107 - - 0.0000000000000000000002188 102.0
HFD2_k127_7831348_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 617.0
HFD2_k127_7831348_40 histone H2A K63-linked ubiquitination K01205,K07004,K12132 - 2.7.11.1,3.2.1.50 0.0000000000000000000003569 108.0
HFD2_k127_7831348_41 Domain of unknown function (DUF4870) - - - 0.000000000000000000001185 100.0
HFD2_k127_7831348_42 transcriptional - - - 0.0000000000000000001011 94.0
HFD2_k127_7831348_43 VanZ like family - - - 0.0000000000000001225 83.0
HFD2_k127_7831348_44 Carboxypeptidase regulatory-like domain - - - 0.0000000000004835 82.0
HFD2_k127_7831348_45 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000001341 68.0
HFD2_k127_7831348_46 Response regulator, receiver K11443 - - 0.000000000001826 74.0
HFD2_k127_7831348_47 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000002598 65.0
HFD2_k127_7831348_48 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000001397 56.0
HFD2_k127_7831348_49 Vitamin k epoxide reductase K00368 - 1.7.2.1 0.000009414 53.0
HFD2_k127_7831348_5 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 588.0
HFD2_k127_7831348_50 Tetratricopeptide repeat - - - 0.0003875 52.0
HFD2_k127_7831348_51 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0004016 49.0
HFD2_k127_7831348_52 Protein of unknown function (DUF4019) - - - 0.0004918 50.0
HFD2_k127_7831348_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 600.0
HFD2_k127_7831348_7 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 536.0
HFD2_k127_7831348_8 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003323 504.0
HFD2_k127_7831348_9 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 456.0
HFD2_k127_7916130_0 helicase activity - - - 0.0 1024.0
HFD2_k127_7916130_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 475.0
HFD2_k127_7916130_2 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 404.0
HFD2_k127_7916130_3 Belongs to the ABC transporter superfamily K02010,K10112 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 383.0
HFD2_k127_7916130_4 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008623 306.0
HFD2_k127_7916130_5 transmembrane transport K02025,K15771 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004023 282.0
HFD2_k127_7916130_6 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009382 256.0
HFD2_k127_7916130_7 Monooxygenase fad-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000008518 211.0
HFD2_k127_7916130_8 cAMP biosynthetic process - - - 0.000000000000000000001534 110.0
HFD2_k127_7918022_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.223e-234 742.0
HFD2_k127_7918022_1 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 6.238e-214 677.0
HFD2_k127_7918022_10 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 337.0
HFD2_k127_7918022_11 TOBE domain K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 303.0
HFD2_k127_7918022_12 Deoxyhypusine synthase K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000507 286.0
HFD2_k127_7918022_13 PFAM short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000038 252.0
HFD2_k127_7918022_14 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000004125 228.0
HFD2_k127_7918022_15 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000002132 194.0
HFD2_k127_7918022_16 Bacterial regulatory proteins, tetR family K09017 - - 0.0000000000000000000000000000000000000465 151.0
HFD2_k127_7918022_17 diguanylate cyclase - - - 0.00000000000000000000001997 114.0
HFD2_k127_7918022_18 Protein of unknown function (DUF3047) - - - 0.00000000000009921 79.0
HFD2_k127_7918022_19 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000127 63.0
HFD2_k127_7918022_2 benzoyl-CoA oxygenase K15512 - 1.14.13.208 1.215e-213 672.0
HFD2_k127_7918022_20 Protein of unknown function (DUF721) - - - 0.00001443 53.0
HFD2_k127_7918022_3 glutamine synthetase K01915 GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 4.19e-207 653.0
HFD2_k127_7918022_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 541.0
HFD2_k127_7918022_5 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 430.0
HFD2_k127_7918022_6 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 365.0
HFD2_k127_7918022_7 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 351.0
HFD2_k127_7918022_8 PFAM GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 354.0
HFD2_k127_7918022_9 pfam abc K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 310.0
HFD2_k127_7930043_0 in Yersinia the HmsR protein is an inner membrane protein K11936 - - 0.0 1149.0
HFD2_k127_7930043_1 4Fe-4S dicluster domain K00184 - - 0.0 1058.0
HFD2_k127_7930043_10 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 562.0
HFD2_k127_7930043_11 Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 536.0
HFD2_k127_7930043_12 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 487.0
HFD2_k127_7930043_13 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 484.0
HFD2_k127_7930043_14 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 479.0
HFD2_k127_7930043_15 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 447.0
HFD2_k127_7930043_16 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 417.0
HFD2_k127_7930043_17 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 420.0
HFD2_k127_7930043_18 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 402.0
HFD2_k127_7930043_19 PFAM amino acid permease-associated region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009604 400.0
HFD2_k127_7930043_2 PrkA AAA domain protein K07180 - - 9.408e-306 948.0
HFD2_k127_7930043_20 Sodium:dicarboxylate symporter family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 398.0
HFD2_k127_7930043_21 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 387.0
HFD2_k127_7930043_22 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 383.0
HFD2_k127_7930043_23 Major facilitator Superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 377.0
HFD2_k127_7930043_24 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 370.0
HFD2_k127_7930043_25 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 369.0
HFD2_k127_7930043_26 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 356.0
HFD2_k127_7930043_27 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 336.0
HFD2_k127_7930043_28 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 305.0
HFD2_k127_7930043_29 Domain present in PSD-95, Dlg, and ZO-1/2. K08070,K08372 - 1.3.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 307.0
HFD2_k127_7930043_3 Heat shock 70 kDa protein K04043 - - 1.551e-292 909.0
HFD2_k127_7930043_30 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 298.0
HFD2_k127_7930043_31 D-alanyl-d-alanine carboxypeptidase K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 310.0
HFD2_k127_7930043_32 signal sequence binding K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 299.0
HFD2_k127_7930043_33 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 293.0
HFD2_k127_7930043_34 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001111 282.0
HFD2_k127_7930043_35 GHMP kinases C terminal K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007853 285.0
HFD2_k127_7930043_36 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004515 280.0
HFD2_k127_7930043_37 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003551 279.0
HFD2_k127_7930043_38 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008205 268.0
HFD2_k127_7930043_39 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000001222 270.0
HFD2_k127_7930043_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 4.667e-277 860.0
HFD2_k127_7930043_40 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004371 274.0
HFD2_k127_7930043_41 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004334 259.0
HFD2_k127_7930043_42 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007718 275.0
HFD2_k127_7930043_43 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
HFD2_k127_7930043_44 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000006861 231.0
HFD2_k127_7930043_45 - - - - 0.000000000000000000000000000000000000000000000000000000000000006378 229.0
HFD2_k127_7930043_46 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000000000007795 222.0
HFD2_k127_7930043_47 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000001322 226.0
HFD2_k127_7930043_48 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000008035 222.0
HFD2_k127_7930043_49 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000001237 229.0
HFD2_k127_7930043_5 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 9.355e-265 842.0
HFD2_k127_7930043_50 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000772 211.0
HFD2_k127_7930043_51 spore germination - - - 0.000000000000000000000000000000000000000000000000000000004857 209.0
HFD2_k127_7930043_52 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000003169 193.0
HFD2_k127_7930043_53 Metallophosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000005649 192.0
HFD2_k127_7930043_54 - - - - 0.00000000000000000000000000000000000000000000000002377 187.0
HFD2_k127_7930043_55 - - - - 0.0000000000000000000000000000000000000000000000001943 183.0
HFD2_k127_7930043_56 PFAM metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000001984 181.0
HFD2_k127_7930043_57 Acetyltransferase (GNAT) domain - GO:0003674,GO:0003824,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747 - 0.0000000000000000000000000000000000000000000008138 171.0
HFD2_k127_7930043_58 COG1520 FOG WD40-like repeat - - - 0.000000000000000000000000000000000000000000257 173.0
HFD2_k127_7930043_59 PFAM Ubiquitin-conjugating - - - 0.0000000000000000000000000000000000000000007262 170.0
HFD2_k127_7930043_6 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 3.686e-259 812.0
HFD2_k127_7930043_60 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000005133 157.0
HFD2_k127_7930043_61 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.00000000000000000000000000000000000000001304 160.0
HFD2_k127_7930043_62 histone H2A K63-linked ubiquitination - - - 0.00000000000000000000000000000000000000002185 166.0
HFD2_k127_7930043_63 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000003127 162.0
HFD2_k127_7930043_64 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000001005 151.0
HFD2_k127_7930043_65 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000001418 151.0
HFD2_k127_7930043_66 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000005814 142.0
HFD2_k127_7930043_67 Iron-sulphur cluster biosynthesis - - - 0.000000000000000000000000000000000001097 142.0
HFD2_k127_7930043_68 MerR HTH family regulatory protein K13640 - - 0.000000000000000000000000000000000009501 142.0
HFD2_k127_7930043_69 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000001952 139.0
HFD2_k127_7930043_7 Polysulphide reductase, NrfD K00185 - - 2.44e-219 688.0
HFD2_k127_7930043_70 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.0000000000000000000000000000000007692 145.0
HFD2_k127_7930043_71 Ferredoxin K00529,K04755,K08952,K08953,K08954,K15765 GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 1.18.1.3 0.000000000000000000000000000000003519 141.0
HFD2_k127_7930043_72 proteolysis - - - 0.00000000000000000000000000000001002 141.0
HFD2_k127_7930043_73 Urate oxidase N-terminal - - - 0.00000000000000000000000000000326 130.0
HFD2_k127_7930043_74 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.000000000000000000000000000008451 125.0
HFD2_k127_7930043_75 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41 0.000000000000000000000000000008475 126.0
HFD2_k127_7930043_76 WXG100 protein secretion system (Wss), protein YukD - - - 0.00000000000000000000000000008758 118.0
HFD2_k127_7930043_77 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000006478 119.0
HFD2_k127_7930043_78 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000009619 112.0
HFD2_k127_7930043_79 palmitoyl-(protein) hydrolase activity K06999 - - 0.00000000000000000000000007413 118.0
HFD2_k127_7930043_8 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.86e-217 691.0
HFD2_k127_7930043_80 PFAM UspA domain protein K06149 - - 0.00000000000000000000000008331 113.0
HFD2_k127_7930043_81 Trm112p-like protein K09791 - - 0.00000000000000000000006085 99.0
HFD2_k127_7930043_82 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.0000000000000000000001336 100.0
HFD2_k127_7930043_83 Putative restriction endonuclease - - - 0.00000000000000000003365 97.0
HFD2_k127_7930043_84 3D domain - - - 0.000000000000000003955 91.0
HFD2_k127_7930043_85 Belongs to the Nudix hydrolase family - - - 0.0000000000000000232 87.0
HFD2_k127_7930043_86 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000004616 83.0
HFD2_k127_7930043_87 Membrane - GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944 - 0.0000000000000004323 87.0
HFD2_k127_7930043_89 Protein of unknown function (DUF664) - - - 0.0000000005164 68.0
HFD2_k127_7930043_9 Phosphoenolpyruvate carboxykinase K01610 - 4.1.1.49 2.814e-206 654.0
HFD2_k127_7930043_90 Bacterial PH domain K08981 - - 0.0000000052 65.0
HFD2_k127_7930043_91 Modulates RecA activity K03565 - - 0.0000001087 60.0
HFD2_k127_7930043_92 Putative peptidoglycan binding domain - - - 0.0000001356 58.0
HFD2_k127_7930043_93 Domain of unknown function (DUF4440) - - - 0.000005409 56.0
HFD2_k127_7930043_95 Domain of unknown function (DUF4388) K12132 - 2.7.11.1 0.00008808 53.0
HFD2_k127_7972414_0 Belongs to the DegT DnrJ EryC1 family K20429 - 2.6.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 557.0
HFD2_k127_7972414_1 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 421.0
HFD2_k127_7972414_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000009759 100.0
HFD2_k127_7972414_11 - - - - 0.000000000000000005804 93.0
HFD2_k127_7972414_2 ATPases associated with a variety of cellular activities K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 385.0
HFD2_k127_7972414_3 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 350.0
HFD2_k127_7972414_4 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 332.0
HFD2_k127_7972414_5 beta-fructofuranosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 333.0
HFD2_k127_7972414_6 COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 304.0
HFD2_k127_7972414_8 Methyltransferase type 11 Methyltransferase type 12 - - - 0.0000000000000000000000000000000000000000008752 166.0
HFD2_k127_7972414_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000002437 151.0
HFD2_k127_7985600_0 enterobactin catabolic process - - - 6.155e-287 889.0
HFD2_k127_7985600_1 PFAM DNA mismatch repair protein MutS domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 497.0
HFD2_k127_7985600_2 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007603 394.0
HFD2_k127_7985600_3 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 338.0
HFD2_k127_7985600_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005208 240.0
HFD2_k127_7985600_5 ATP dependent DNA ligase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000005211 243.0
HFD2_k127_7985600_6 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.00000000000000000000000000000000000001139 156.0
HFD2_k127_7985600_7 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000006687 145.0
HFD2_k127_7985600_8 NIPSNAP - - - 0.0000000000000000000001081 101.0
HFD2_k127_7985600_9 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.00000000000000000007515 91.0
HFD2_k127_7990042_0 Aconitase C-terminal domain K01703 - 4.2.1.33,4.2.1.35 3.951e-284 886.0
HFD2_k127_7990042_1 Peptidase dimerisation domain K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 483.0
HFD2_k127_7990042_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 439.0
HFD2_k127_7990042_3 DinB family - - - 0.0000000000000000000000000000000000000000000002212 172.0
HFD2_k127_7990042_4 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000009561 165.0
HFD2_k127_7990042_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000001674 136.0
HFD2_k127_7990042_6 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.000000000000000000000000000001454 127.0
HFD2_k127_7990042_7 Tetratricopeptide repeat - - - 0.0004568 49.0
HFD2_k127_7990042_8 Putative zinc-finger - - - 0.0006586 51.0
HFD2_k127_8010551_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 9.312e-269 843.0
HFD2_k127_8010551_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.626e-267 830.0
HFD2_k127_8010551_10 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 320.0
HFD2_k127_8010551_11 methyltransferase activity K00574,K12240,K18534,K19620,K20444 - 2.1.1.295,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 309.0
HFD2_k127_8010551_12 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 300.0
HFD2_k127_8010551_13 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006721 303.0
HFD2_k127_8010551_14 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 310.0
HFD2_k127_8010551_15 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 297.0
HFD2_k127_8010551_16 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000001062 267.0
HFD2_k127_8010551_17 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000242 254.0
HFD2_k127_8010551_18 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005019 257.0
HFD2_k127_8010551_19 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000001612 241.0
HFD2_k127_8010551_2 Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate K00294 - 1.2.1.88 4.576e-210 664.0
HFD2_k127_8010551_20 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000003094 201.0
HFD2_k127_8010551_22 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000006055 156.0
HFD2_k127_8010551_23 DinB family - - - 0.000000000000000000003945 99.0
HFD2_k127_8010551_24 PFAM CHRD domain containing protein - - - 0.00000000000005515 87.0
HFD2_k127_8010551_25 aggregation factor core protein MAFp3, isoform C - - - 0.0000000000002876 85.0
HFD2_k127_8010551_26 zinc metalloprotease K11749 - - 0.000000000000749 76.0
HFD2_k127_8010551_27 Reeler domain - - - 0.00000000007072 77.0
HFD2_k127_8010551_28 Tetratricopeptide repeat - - - 0.000000003282 69.0
HFD2_k127_8010551_29 Proprotein convertase P-domain - - - 0.000000005777 70.0
HFD2_k127_8010551_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 567.0
HFD2_k127_8010551_30 PFAM helix-turn-helix, Fis-type - - - 0.0000004889 54.0
HFD2_k127_8010551_31 - - - - 0.0000009721 60.0
HFD2_k127_8010551_32 Domain of unknown function (DUF4388) - - - 0.000001113 59.0
HFD2_k127_8010551_33 - - - - 0.000001818 60.0
HFD2_k127_8010551_34 serine threonine protein kinase K12132 - 2.7.11.1 0.00001687 55.0
HFD2_k127_8010551_35 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0001469 54.0
HFD2_k127_8010551_4 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 523.0
HFD2_k127_8010551_5 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 547.0
HFD2_k127_8010551_6 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 444.0
HFD2_k127_8010551_7 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 393.0
HFD2_k127_8010551_8 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 363.0
HFD2_k127_8010551_9 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 338.0
HFD2_k127_8013095_0 Amino acid permease K03294 - - 4.911e-205 650.0
HFD2_k127_8013095_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 597.0
HFD2_k127_8013095_10 chlorophyll binding - - - 0.000158 44.0
HFD2_k127_8013095_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 532.0
HFD2_k127_8013095_3 DNA polymerase K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 469.0
HFD2_k127_8013095_4 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003628 433.0
HFD2_k127_8013095_5 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 337.0
HFD2_k127_8013095_6 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005895 290.0
HFD2_k127_8013095_7 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000005106 191.0
HFD2_k127_8013095_8 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000003992 168.0
HFD2_k127_8013095_9 Protein of unknown function (DUF664) - - - 0.00002493 50.0
HFD2_k127_8054898_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 2.564e-310 970.0
HFD2_k127_8054898_1 iron-nicotianamine transmembrane transporter activity - - - 9.19e-286 901.0
HFD2_k127_8054898_10 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 355.0
HFD2_k127_8054898_11 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 327.0
HFD2_k127_8054898_12 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 321.0
HFD2_k127_8054898_13 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 318.0
HFD2_k127_8054898_14 PFAM Enoyl-CoA hydratase isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 297.0
HFD2_k127_8054898_15 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001008 285.0
HFD2_k127_8054898_16 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007815 253.0
HFD2_k127_8054898_17 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000004174 214.0
HFD2_k127_8054898_18 Tryptophan 2,3-dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000002323 210.0
HFD2_k127_8054898_19 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000008362 182.0
HFD2_k127_8054898_2 NADH oxidase - - - 1.399e-198 629.0
HFD2_k127_8054898_20 TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000001322 151.0
HFD2_k127_8054898_21 YHS domain K06966 - 3.2.2.10 0.00000000000000000000000000000000000214 145.0
HFD2_k127_8054898_22 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000001188 136.0
HFD2_k127_8054898_23 PFAM HD domain - - - 0.0000000000000000000000000000002149 133.0
HFD2_k127_8054898_24 transcriptional regulator K03655 - 3.6.4.12 0.0000000000000000000000000000003166 138.0
HFD2_k127_8054898_25 NAD+ binding - - - 0.0000000000000000000000000000003419 142.0
HFD2_k127_8054898_26 Carbohydrate family 9 binding domain-like - - - 0.00000000000000000000000007287 115.0
HFD2_k127_8054898_27 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000004935 109.0
HFD2_k127_8054898_28 - - - - 0.00000000000002772 87.0
HFD2_k127_8054898_29 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000001483 71.0
HFD2_k127_8054898_3 cell adhesion involved in biofilm formation K13735,K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 638.0
HFD2_k127_8054898_30 Thioredoxin-like - - - 0.0000000001068 69.0
HFD2_k127_8054898_31 - - - - 0.000000009407 68.0
HFD2_k127_8054898_32 Protein conserved in bacteria - - - 0.0004784 51.0
HFD2_k127_8054898_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 523.0
HFD2_k127_8054898_5 Aminotransferase class-V K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 463.0
HFD2_k127_8054898_6 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 415.0
HFD2_k127_8054898_7 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 394.0
HFD2_k127_8054898_8 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 361.0
HFD2_k127_8054898_9 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 364.0
HFD2_k127_8062651_0 PFAM Prolyl oligopeptidase family - - - 1.135e-275 861.0
HFD2_k127_8062651_1 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 561.0
HFD2_k127_8062651_2 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000000000000000000001802 229.0
HFD2_k127_8062651_3 - - - - 0.00001065 52.0
HFD2_k127_8080212_0 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 411.0
HFD2_k127_8080212_1 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 299.0
HFD2_k127_8080212_10 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000006213 141.0
HFD2_k127_8080212_11 HEAT repeats - - - 0.000000000000000000000000000005465 136.0
HFD2_k127_8080212_12 - - - - 0.00000000000000000000000000003453 121.0
HFD2_k127_8080212_13 - - - - 0.000000000000000000000001463 112.0
HFD2_k127_8080212_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000001381 81.0
HFD2_k127_8080212_15 PFAM Glycosyl transferase, group 1 - - - 0.00000000000005224 76.0
HFD2_k127_8080212_16 Family of unknown function (DUF5339) - - - 0.000000000004315 72.0
HFD2_k127_8080212_17 Nacht domain - - - 0.000000006673 68.0
HFD2_k127_8080212_18 Putative zinc-finger - - - 0.0003753 52.0
HFD2_k127_8080212_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002297 284.0
HFD2_k127_8080212_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001422 259.0
HFD2_k127_8080212_4 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000005774 239.0
HFD2_k127_8080212_5 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000392 233.0
HFD2_k127_8080212_6 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000004115 202.0
HFD2_k127_8080212_7 transferase activity, transferring glycosyl groups K07011 - - 0.00000000000000000000000000000000000000000000000000001437 204.0
HFD2_k127_8080212_8 PFAM MgtC SapB transporter K07507 - - 0.000000000000000000000000000000000000000000004611 168.0
HFD2_k127_8080212_9 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000000000001439 141.0
HFD2_k127_824751_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 462.0
HFD2_k127_824751_1 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 373.0
HFD2_k127_824751_10 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000006948 175.0
HFD2_k127_824751_11 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000003871 171.0
HFD2_k127_824751_12 tRNA threonylcarbamoyladenosine modification K06925,K07102 - 2.7.1.221 0.00000000000000000000000000000000000006251 149.0
HFD2_k127_824751_13 Lytic transglycosylase catalytic K08309 - - 0.00000000000000000000000000000000000221 159.0
HFD2_k127_824751_14 tRNA threonylcarbamoyladenosine modification K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - 0.000000000000000000006794 100.0
HFD2_k127_824751_15 heat shock protein binding - - - 0.0000000004297 70.0
HFD2_k127_824751_16 heat shock protein binding - - - 0.0000003423 61.0
HFD2_k127_824751_17 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000003604 59.0
HFD2_k127_824751_2 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 351.0
HFD2_k127_824751_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 345.0
HFD2_k127_824751_4 extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 297.0
HFD2_k127_824751_5 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002006 273.0
HFD2_k127_824751_6 Copper binding periplasmic protein CusF K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001249 276.0
HFD2_k127_824751_7 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003853 267.0
HFD2_k127_824751_8 L-threonylcarbamoyladenylate synthase K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000004774 234.0
HFD2_k127_824751_9 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000004209 229.0
HFD2_k127_8302655_0 PFAM TonB-dependent Receptor Plug - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009973 332.0
HFD2_k127_8302655_1 Glycosyl hydrolase-like 10 - - - 0.00000000000002274 78.0
HFD2_k127_8595509_0 amino acid - - - 8.152e-261 818.0
HFD2_k127_8595509_1 amino acid - - - 5.127e-257 808.0
HFD2_k127_8595509_10 Domain of unknown function (DUF4070) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 495.0
HFD2_k127_8595509_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 474.0
HFD2_k127_8595509_12 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 453.0
HFD2_k127_8595509_13 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 469.0
HFD2_k127_8595509_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 449.0
HFD2_k127_8595509_15 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 418.0
HFD2_k127_8595509_16 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 392.0
HFD2_k127_8595509_17 Transmembrane secretion effector K08225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 374.0
HFD2_k127_8595509_18 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 363.0
HFD2_k127_8595509_19 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 348.0
HFD2_k127_8595509_2 phosphorylase K00688 - 2.4.1.1 6.354e-247 781.0
HFD2_k127_8595509_20 Leucine-rich repeat K13730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 358.0
HFD2_k127_8595509_21 including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009545 305.0
HFD2_k127_8595509_22 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 309.0
HFD2_k127_8595509_23 PFAM Response regulator receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 294.0
HFD2_k127_8595509_24 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001294 291.0
HFD2_k127_8595509_25 Oxidoreductase activity. It is involved in the biological process described with metabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000693 285.0
HFD2_k127_8595509_26 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003198 278.0
HFD2_k127_8595509_27 RNA 2'-O ribose methyltransferase substrate binding K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000003076 255.0
HFD2_k127_8595509_28 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008225 250.0
HFD2_k127_8595509_29 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000001072 239.0
HFD2_k127_8595509_3 Elongation factor G, domain IV K02355 - - 4.395e-227 726.0
HFD2_k127_8595509_30 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000002666 237.0
HFD2_k127_8595509_31 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000009411 241.0
HFD2_k127_8595509_32 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000002527 214.0
HFD2_k127_8595509_33 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000000000000000000000000000000009186 210.0
HFD2_k127_8595509_34 - - - - 0.00000000000000000000000000000000000000000000000000000005172 209.0
HFD2_k127_8595509_35 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000002466 214.0
HFD2_k127_8595509_36 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.00000000000000000000000000000000000000000000000000004121 196.0
HFD2_k127_8595509_37 Serine Threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000001244 209.0
HFD2_k127_8595509_38 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K07291 - 2.7.8.34 0.000000000000000000000000000000000000000000000000001366 194.0
HFD2_k127_8595509_39 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000009029 183.0
HFD2_k127_8595509_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 4.31e-197 646.0
HFD2_k127_8595509_40 actin binding - - - 0.00000000000000000000000000000000000000000003506 178.0
HFD2_k127_8595509_41 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000001539 167.0
HFD2_k127_8595509_42 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000004424 177.0
HFD2_k127_8595509_43 serine-type endopeptidase activity - - - 0.0000000000000000000000000000000000000000004733 168.0
HFD2_k127_8595509_44 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000001589 159.0
HFD2_k127_8595509_45 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000001129 148.0
HFD2_k127_8595509_47 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000001499 144.0
HFD2_k127_8595509_48 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000004059 156.0
HFD2_k127_8595509_49 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000003237 132.0
HFD2_k127_8595509_5 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 580.0
HFD2_k127_8595509_50 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000177 128.0
HFD2_k127_8595509_51 Probable zinc-ribbon domain - - - 0.000000000000000000000000000007962 122.0
HFD2_k127_8595509_52 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000002381 119.0
HFD2_k127_8595509_53 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000003881 117.0
HFD2_k127_8595509_54 ComF family K02242 - - 0.000000000000000000000000003599 121.0
HFD2_k127_8595509_55 - - - - 0.000000000000000000000000004223 112.0
HFD2_k127_8595509_56 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000001891 116.0
HFD2_k127_8595509_57 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000003393 116.0
HFD2_k127_8595509_58 - - - - 0.0000000000000000000000007894 114.0
HFD2_k127_8595509_59 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000001635 106.0
HFD2_k127_8595509_6 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 574.0
HFD2_k127_8595509_60 Protein of unknown function (DUF971) - - - 0.000000000000000000000004697 104.0
HFD2_k127_8595509_61 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000003391 103.0
HFD2_k127_8595509_62 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000003168 96.0
HFD2_k127_8595509_63 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000000009366 104.0
HFD2_k127_8595509_64 Protein of unknown function (DUF2847) - - - 0.0000000000000000009924 91.0
HFD2_k127_8595509_65 Domain of unknown function (DUF4384) - - - 0.000000000000000008926 94.0
HFD2_k127_8595509_66 - - - - 0.0000000000000008575 88.0
HFD2_k127_8595509_68 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000009819 52.0
HFD2_k127_8595509_69 ArsR family transcriptional regulator - - - 0.000001991 59.0
HFD2_k127_8595509_7 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 557.0
HFD2_k127_8595509_70 COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K10126 - - 0.000267 51.0
HFD2_k127_8595509_71 BON domain K04065 - - 0.0004357 50.0
HFD2_k127_8595509_72 RNA polymerase-associated protein CTR9 homolog K15176 GO:0000122,GO:0000428,GO:0000785,GO:0000993,GO:0001098,GO:0001099,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006479,GO:0006807,GO:0006996,GO:0008023,GO:0008150,GO:0008152,GO:0008213,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009909,GO:0009910,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010638,GO:0016020,GO:0016043,GO:0016569,GO:0016570,GO:0016571,GO:0016591,GO:0016593,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019219,GO:0019222,GO:0019538,GO:0019899,GO:0030880,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031399,GO:0031401,GO:0031974,GO:0031981,GO:0032259,GO:0032268,GO:0032270,GO:0032784,GO:0032786,GO:0032968,GO:0032991,GO:0033043,GO:0033044,GO:0034243,GO:0034968,GO:0035327,GO:0036211,GO:0043170,GO:0043175,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0044877,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048580,GO:0048581,GO:0048831,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051568,GO:0051569,GO:0051571,GO:0055029,GO:0060255,GO:0061695,GO:0065007,GO:0070013,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0080182,GO:1901564,GO:1902275,GO:1902494,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1905269,GO:1990234,GO:2000026,GO:2000112,GO:2000113,GO:2000241,GO:2000242,GO:2001141,GO:2001252 - 0.0009232 51.0
HFD2_k127_8595509_8 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 544.0
HFD2_k127_8595509_9 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 539.0
HFD2_k127_8700820_0 Zinc carboxypeptidase - - - 1.999e-221 711.0
HFD2_k127_8700820_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 6.33e-200 639.0
HFD2_k127_8700820_10 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000000000000000000000000000000006576 222.0
HFD2_k127_8700820_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000003227 216.0
HFD2_k127_8700820_12 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000003735 192.0
HFD2_k127_8700820_13 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000001203 198.0
HFD2_k127_8700820_14 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000005082 155.0
HFD2_k127_8700820_15 CHRD domain - - - 0.000000000000000000000000000000000008741 141.0
HFD2_k127_8700820_16 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000006326 122.0
HFD2_k127_8700820_17 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.0000000000000000000000005479 109.0
HFD2_k127_8700820_18 - - - - 0.000000000000000005439 92.0
HFD2_k127_8700820_19 multi-organism process - - - 0.000000000001439 81.0
HFD2_k127_8700820_2 SPFH domain / Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 571.0
HFD2_k127_8700820_20 Domain of unknown function (DUF1844) - - - 0.000000000001619 75.0
HFD2_k127_8700820_21 Putative adhesin - - - 0.000000009663 65.0
HFD2_k127_8700820_22 - - - - 0.00003452 55.0
HFD2_k127_8700820_23 membrane - - - 0.0001334 52.0
HFD2_k127_8700820_24 Putative zinc-finger K03088 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0001352 52.0
HFD2_k127_8700820_3 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 473.0
HFD2_k127_8700820_4 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 360.0
HFD2_k127_8700820_5 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 356.0
HFD2_k127_8700820_6 Protein containing tetrapyrrole methyltransferase domain and MazG-like K02428,K02499 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000001177 259.0
HFD2_k127_8700820_7 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001187 269.0
HFD2_k127_8700820_8 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000155 250.0
HFD2_k127_8700820_9 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000005383 249.0
HFD2_k127_870147_0 arylsulfatase activity K01130 - 3.1.6.1 0.0 1305.0
HFD2_k127_870147_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.201e-215 682.0
HFD2_k127_870147_10 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000038 254.0
HFD2_k127_870147_11 iron-sulfur cluster biosynthesis transcriptional regulator SufR K09012 - - 0.00000000000000000000000000000000000000000000000000000000000000000007124 237.0
HFD2_k127_870147_12 Cytidylyltransferase K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000007366 230.0
HFD2_k127_870147_13 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000003586 243.0
HFD2_k127_870147_14 Bacteriocin-protection protein - - - 0.00000000000000000000000000000000000000000000000000000000003126 213.0
HFD2_k127_870147_15 -acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000003528 198.0
HFD2_k127_870147_16 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000001065 195.0
HFD2_k127_870147_17 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000006601 180.0
HFD2_k127_870147_18 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000002593 174.0
HFD2_k127_870147_19 Protein of unknown function (DUF2490) - - - 0.000000000000000000000000000000000139 142.0
HFD2_k127_870147_2 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006827 458.0
HFD2_k127_870147_20 Peptidase M56 - - - 0.000000000000000000000002159 115.0
HFD2_k127_870147_21 Domain of unknown function (DUF202) K00389 - - 0.000000000000000000002009 100.0
HFD2_k127_870147_22 iron assimilation - - - 0.000000784 53.0
HFD2_k127_870147_23 - - - - 0.000009475 49.0
HFD2_k127_870147_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 396.0
HFD2_k127_870147_4 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 366.0
HFD2_k127_870147_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 356.0
HFD2_k127_870147_6 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 336.0
HFD2_k127_870147_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 338.0
HFD2_k127_870147_8 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 345.0
HFD2_k127_870147_9 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 301.0
HFD2_k127_8750292_0 DEAD DEAH box helicase K03724 - - 0.0 1740.0
HFD2_k127_8750292_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.307e-310 964.0
HFD2_k127_8750292_10 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 486.0
HFD2_k127_8750292_11 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 452.0
HFD2_k127_8750292_12 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000544 449.0
HFD2_k127_8750292_13 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 441.0
HFD2_k127_8750292_14 Sodium:sulfate symporter transmembrane region K03319 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 446.0
HFD2_k127_8750292_15 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 419.0
HFD2_k127_8750292_16 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 419.0
HFD2_k127_8750292_17 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 422.0
HFD2_k127_8750292_18 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 408.0
HFD2_k127_8750292_19 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 399.0
HFD2_k127_8750292_2 metallocarboxypeptidase activity K14054 - - 4.212e-286 911.0
HFD2_k127_8750292_20 Peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 391.0
HFD2_k127_8750292_21 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 360.0
HFD2_k127_8750292_22 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009907 361.0
HFD2_k127_8750292_23 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 342.0
HFD2_k127_8750292_24 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 348.0
HFD2_k127_8750292_25 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 323.0
HFD2_k127_8750292_26 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000631 318.0
HFD2_k127_8750292_27 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 306.0
HFD2_k127_8750292_28 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 301.0
HFD2_k127_8750292_29 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008654 299.0
HFD2_k127_8750292_3 metalloendopeptidase activity K01283 - 3.4.15.1 7.562e-257 804.0
HFD2_k127_8750292_30 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001615 290.0
HFD2_k127_8750292_31 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002349 274.0
HFD2_k127_8750292_32 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001476 276.0
HFD2_k127_8750292_33 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003336 269.0
HFD2_k127_8750292_34 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000001528 261.0
HFD2_k127_8750292_35 COG1230 Co Zn Cd efflux system component K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009109 265.0
HFD2_k127_8750292_36 helix_turn_helix gluconate operon transcriptional repressor K07978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001937 249.0
HFD2_k127_8750292_37 Xylose isomerase-like TIM barrel K06606 - 5.3.99.11 0.000000000000000000000000000000000000000000000000000000000000000004577 234.0
HFD2_k127_8750292_38 surface antigen variable number - - - 0.0000000000000000000000000000000000000000000000000000000000000227 245.0
HFD2_k127_8750292_39 Lumazine binding domain K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000004616 216.0
HFD2_k127_8750292_4 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 606.0
HFD2_k127_8750292_40 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001334 211.0
HFD2_k127_8750292_41 Belongs to the UPF0502 family K09915 - - 0.000000000000000000000000000000000000000000000000000000008006 205.0
HFD2_k127_8750292_42 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000003743 205.0
HFD2_k127_8750292_43 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000001107 196.0
HFD2_k127_8750292_44 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000292 193.0
HFD2_k127_8750292_45 PFAM Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000005307 200.0
HFD2_k127_8750292_46 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000001804 187.0
HFD2_k127_8750292_47 EVE domain - - - 0.000000000000000000000000000000000000000000000001407 177.0
HFD2_k127_8750292_48 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000003161 181.0
HFD2_k127_8750292_49 Patatin-like phospholipase K07001 GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000000000000000000000000000000000324 183.0
HFD2_k127_8750292_5 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 573.0
HFD2_k127_8750292_50 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000008313 174.0
HFD2_k127_8750292_51 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000002987 170.0
HFD2_k127_8750292_52 Y_Y_Y domain - - - 0.0000000000000000000000000000000000000004191 173.0
HFD2_k127_8750292_53 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.000000000000000000000000000000000000001466 158.0
HFD2_k127_8750292_54 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000006717 155.0
HFD2_k127_8750292_55 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000008883 158.0
HFD2_k127_8750292_56 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000001892 160.0
HFD2_k127_8750292_57 oxidoreductase activity K12511 - - 0.00000000000000000000000000000000000004621 156.0
HFD2_k127_8750292_58 metal cluster binding - - - 0.000000000000000000000000000000000002292 145.0
HFD2_k127_8750292_59 AI-2E family transporter - - - 0.000000000000000000000000000000000003299 153.0
HFD2_k127_8750292_6 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 563.0
HFD2_k127_8750292_60 HD domain K07023 - - 0.00000000000000000000000000000000001447 143.0
HFD2_k127_8750292_61 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000003429 146.0
HFD2_k127_8750292_62 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000000004624 134.0
HFD2_k127_8750292_63 - - - - 0.000000000000000000000000001017 117.0
HFD2_k127_8750292_64 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000004098 109.0
HFD2_k127_8750292_65 Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000002584 112.0
HFD2_k127_8750292_66 - catabolite gene activator and regulatory subunit of cAMP-dependent protein K10914 - - 0.0000000000000000000000154 109.0
HFD2_k127_8750292_67 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000004637 106.0
HFD2_k127_8750292_68 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000008499 87.0
HFD2_k127_8750292_69 zinc-ribbon domain - - - 0.000000000000000166 89.0
HFD2_k127_8750292_7 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 494.0
HFD2_k127_8750292_70 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000007999 82.0
HFD2_k127_8750292_71 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000001433 88.0
HFD2_k127_8750292_72 Cytochrome c biogenesis protein transmembrane region K04084 - 1.8.1.8 0.0000000000001004 77.0
HFD2_k127_8750292_73 mttA/Hcf106 family K03116,K03117 - - 0.000000000001533 73.0
HFD2_k127_8750292_74 protein conserved in bacteria K09800 - - 0.000000000006094 81.0
HFD2_k127_8750292_75 peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000001022 68.0
HFD2_k127_8750292_77 Serine Threonine protein kinase K12132 - 2.7.11.1 0.000002168 60.0
HFD2_k127_8750292_78 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00002482 55.0
HFD2_k127_8750292_8 family UPF0027 K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 472.0
HFD2_k127_8750292_9 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 474.0
HFD2_k127_925535_0 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 526.0
HFD2_k127_925535_1 Calcineurin-like phosphoesterase superfamily domain K07498 - - 0.00000000000000000000000000000000000000000000000000000000000000000002489 241.0
HFD2_k127_93269_0 WD domain, G-beta repeat - - - 1.477e-226 747.0
HFD2_k127_93269_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 584.0
HFD2_k127_93269_10 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 308.0
HFD2_k127_93269_11 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002409 265.0
HFD2_k127_93269_12 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000007592 235.0
HFD2_k127_93269_13 SEC-C domain protein K09858 - - 0.000000000000000000000000000000000000000000001425 169.0
HFD2_k127_93269_14 Extracellular nuclease - - - 0.000000000000000000000000000000000000000000007025 190.0
HFD2_k127_93269_15 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000007399 137.0
HFD2_k127_93269_16 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000001809 114.0
HFD2_k127_93269_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000008027 114.0
HFD2_k127_93269_18 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000001291 119.0
HFD2_k127_93269_19 - - - - 0.0000000000000000005756 94.0
HFD2_k127_93269_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 515.0
HFD2_k127_93269_20 - - - - 0.00000000000000001447 91.0
HFD2_k127_93269_21 - - - - 0.0000000000000005709 85.0
HFD2_k127_93269_22 Protein of unknown function (DUF3761) - - - 0.0000000003584 64.0
HFD2_k127_93269_23 ig-like, plexins, transcription factors - - - 0.0000000003955 75.0
HFD2_k127_93269_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 426.0
HFD2_k127_93269_4 PDZ domain (Also known as DHR or GLGF) K08372 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 411.0
HFD2_k127_93269_5 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 400.0
HFD2_k127_93269_6 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 360.0
HFD2_k127_93269_7 IgA Peptidase M64 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 345.0
HFD2_k127_93269_8 Domain of unknown function (DUF5122) beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 353.0
HFD2_k127_93269_9 DUF218 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005239 312.0
HFD2_k127_950251_0 Zinc-binding dehydrogenase - - - 1.5e-286 897.0
HFD2_k127_950251_1 transferase activity, transferring glycosyl groups K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 391.0
HFD2_k127_950251_10 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000003414 179.0
HFD2_k127_950251_11 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000002211 179.0
HFD2_k127_950251_12 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.000000000000000000000000000000000000000000002655 181.0
HFD2_k127_950251_13 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000009073 169.0
HFD2_k127_950251_14 PFAM Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000005964 164.0
HFD2_k127_950251_15 methyltransferase - - - 0.00000000000000000000000000008428 124.0
HFD2_k127_950251_16 6-phosphogluconolactonase activity - - - 0.000000000000000006169 100.0
HFD2_k127_950251_17 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - 0.00000000000000004834 94.0
HFD2_k127_950251_18 Cellulase (glycosyl hydrolase family 5) K01179 - 3.2.1.4 0.000000000000000661 94.0
HFD2_k127_950251_19 Cellulose Binding Domain Type IV - - - 0.000000000000009602 89.0
HFD2_k127_950251_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 383.0
HFD2_k127_950251_20 Cadherin-like beta sandwich domain - - - 0.0000000000003684 85.0
HFD2_k127_950251_21 PFAM Endonuclease Exonuclease phosphatase - - - 0.00000001236 67.0
HFD2_k127_950251_22 Endonuclease/Exonuclease/phosphatase family - - - 0.0000002035 64.0
HFD2_k127_950251_23 O-antigen ligase like membrane protein - - - 0.0000003243 63.0
HFD2_k127_950251_3 transferase activity, transferring glycosyl groups K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 331.0
HFD2_k127_950251_4 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002099 276.0
HFD2_k127_950251_5 Phosphoesterase family K21302 - 3.1.3.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000002294 296.0
HFD2_k127_950251_6 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001207 264.0
HFD2_k127_950251_7 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000004768 210.0
HFD2_k127_950251_8 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000005653 209.0
HFD2_k127_950251_9 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000003715 188.0
HFD2_k127_965918_0 Sortilin, neurotensin receptor 3, - - - 0.0 1379.0
HFD2_k127_965918_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.579e-247 779.0
HFD2_k127_965918_10 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 396.0
HFD2_k127_965918_11 symporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 380.0
HFD2_k127_965918_12 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005819 333.0
HFD2_k127_965918_13 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004839 300.0
HFD2_k127_965918_14 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 289.0
HFD2_k127_965918_15 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008856 283.0
HFD2_k127_965918_16 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000176 238.0
HFD2_k127_965918_17 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000002292 235.0
HFD2_k127_965918_18 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000803 191.0
HFD2_k127_965918_19 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000001198 192.0
HFD2_k127_965918_2 Sodium:solute symporter family - - - 2.094e-244 769.0
HFD2_k127_965918_20 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000007294 168.0
HFD2_k127_965918_21 LysR substrate binding domain K21703 - - 0.00000000000000000000000000000000000000741 157.0
HFD2_k127_965918_22 Bacterial regulatory proteins, gntR family - - - 0.000001727 54.0
HFD2_k127_965918_23 SMART Rhodanese domain protein - - - 0.000003583 49.0
HFD2_k127_965918_24 energy transducer activity K03832 - - 0.00001374 57.0
HFD2_k127_965918_3 Alpha/beta hydrolase family - - - 6.293e-208 666.0
HFD2_k127_965918_4 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 607.0
HFD2_k127_965918_5 Domain of unknown function (DUF3536) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000601 516.0
HFD2_k127_965918_6 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 505.0
HFD2_k127_965918_7 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 497.0
HFD2_k127_965918_8 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 459.0
HFD2_k127_965918_9 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 404.0