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Overview

ID MAG01632
Name HFD2_bin.17
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_E
Class Deferrimicrobia
Order Deferrimicrobiales
Family Deferrimicrobiaceae
Genus FEB-35
Species
Assembly information
Completeness (%) 97.2
Contamination (%) 3.28
GC content (%) 65.0
N50 (bp) 24,282
Genome size (bp) 2,598,669

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2428

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1099022_0 Proprotein convertase P-domain - - - 1.784e-284 893.0
HFD2_k127_1099022_1 response regulator K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 377.0
HFD2_k127_1099022_2 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase K03606 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008153 259.0
HFD2_k127_1099022_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000000000000006055 196.0
HFD2_k127_1099022_4 PFAM ATP-binding region, ATPase domain protein K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000003928 199.0
HFD2_k127_1099022_5 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000001129 201.0
HFD2_k127_1099022_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000904 145.0
HFD2_k127_1099022_7 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000000000000001528 90.0
HFD2_k127_1162074_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1347.0
HFD2_k127_1162074_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 501.0
HFD2_k127_1162074_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 330.0
HFD2_k127_1162074_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 288.0
HFD2_k127_1162074_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000001567 165.0
HFD2_k127_1162074_5 Haem-degrading - - - 0.0000000000000000000000000000000000001745 150.0
HFD2_k127_1162074_6 - - - - 0.00000000000000000000000007431 108.0
HFD2_k127_1162074_7 - - - - 0.000000000000000001844 88.0
HFD2_k127_1216479_0 COG0457 FOG TPR repeat - - - 3.494e-261 817.0
HFD2_k127_1216479_1 PLD-like domain K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 596.0
HFD2_k127_1216479_10 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.00000000000000000000000000000000000000000000000000000000002022 218.0
HFD2_k127_1216479_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000004903 188.0
HFD2_k127_1216479_12 PFAM oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000007476 190.0
HFD2_k127_1216479_13 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000001493 185.0
HFD2_k127_1216479_14 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) - - - 0.00000000000000000000000000000000000004678 152.0
HFD2_k127_1216479_15 BON domain - - - 0.00000000000000000000000001161 117.0
HFD2_k127_1216479_17 ketosteroid isomerase - - - 0.000000000000000009686 92.0
HFD2_k127_1216479_18 Periplasmic or secreted lipoprotein K04065 - - 0.00000000000000175 84.0
HFD2_k127_1216479_19 - - - - 0.0000000000007461 79.0
HFD2_k127_1216479_2 Domain of unknown function (DUF3943) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 517.0
HFD2_k127_1216479_21 Domain of unknown function (DUF1330) - - - 0.00000001584 60.0
HFD2_k127_1216479_22 Domain of unknown function (DUF4398) - - - 0.00000331 54.0
HFD2_k127_1216479_23 Cupin domain - - - 0.0002771 51.0
HFD2_k127_1216479_24 - - - - 0.0009684 46.0
HFD2_k127_1216479_3 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 511.0
HFD2_k127_1216479_4 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 440.0
HFD2_k127_1216479_5 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 389.0
HFD2_k127_1216479_6 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008065 312.0
HFD2_k127_1216479_8 Protein of unknown function (DUF3455) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007075 258.0
HFD2_k127_1216479_9 Carotenoid biosynthesis protein K22502 - 5.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000005062 255.0
HFD2_k127_1225343_0 FtsX-like permease family K02004 - - 1.188e-285 898.0
HFD2_k127_1225343_1 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 534.0
HFD2_k127_1225343_10 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 300.0
HFD2_k127_1225343_11 Putative bacterial lipoprotein (DUF799) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001935 263.0
HFD2_k127_1225343_12 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000000000000000000004594 210.0
HFD2_k127_1225343_13 Domain of unknown function (DUF1848) - - - 0.0000000000000000000000000000000000000000000000000000005295 202.0
HFD2_k127_1225343_14 TraB family K09973 - - 0.0000000000000000000000000000000000000000000002042 181.0
HFD2_k127_1225343_15 Domain of unknown function (DUF4810) - - - 0.0000000000000000000000000000003459 126.0
HFD2_k127_1225343_16 - - - - 0.000000000000000000000000000001225 128.0
HFD2_k127_1225343_17 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000000000002424 117.0
HFD2_k127_1225343_18 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000000002274 109.0
HFD2_k127_1225343_19 - - - - 0.00000000000000000000489 105.0
HFD2_k127_1225343_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 482.0
HFD2_k127_1225343_20 Late embryogenesis abundant protein - - - 0.000005968 55.0
HFD2_k127_1225343_3 FAD dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 441.0
HFD2_k127_1225343_4 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 404.0
HFD2_k127_1225343_5 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 406.0
HFD2_k127_1225343_6 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 373.0
HFD2_k127_1225343_7 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 363.0
HFD2_k127_1225343_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 299.0
HFD2_k127_1225343_9 nucleic acid binding K03698 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 303.0
HFD2_k127_132889_0 Pyruvate synthase K00169 - 1.2.7.1 7.909e-294 936.0
HFD2_k127_132889_1 helix_turn_helix, Lux Regulon - - - 8.625e-219 692.0
HFD2_k127_132889_10 peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 303.0
HFD2_k127_132889_11 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 315.0
HFD2_k127_132889_12 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005161 256.0
HFD2_k127_132889_13 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000007348 231.0
HFD2_k127_132889_14 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.0000000000000000000000000000000000000000000000000003736 195.0
HFD2_k127_132889_15 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000001815 179.0
HFD2_k127_132889_16 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.000000000000000000000000000000000000000000000004467 196.0
HFD2_k127_132889_17 trehalose biosynthetic process K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000003606 182.0
HFD2_k127_132889_18 ABC transporter K01995 - - 0.00000000000000000000000000000000000000005645 173.0
HFD2_k127_132889_19 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000001653 150.0
HFD2_k127_132889_2 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 393.0
HFD2_k127_132889_20 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000001189 155.0
HFD2_k127_132889_21 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000003322 136.0
HFD2_k127_132889_22 CBS domain K04767 - - 0.000000000000000000000000000000001252 137.0
HFD2_k127_132889_23 Major Facilitator Superfamily K08177 - - 0.00000000000000002863 85.0
HFD2_k127_132889_3 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 376.0
HFD2_k127_132889_4 oxidoreductase gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 360.0
HFD2_k127_132889_5 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 361.0
HFD2_k127_132889_6 PFAM peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 349.0
HFD2_k127_132889_7 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 357.0
HFD2_k127_132889_8 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 323.0
HFD2_k127_132889_9 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 325.0
HFD2_k127_1375408_0 General secretory system II, protein E domain protein K02652 - - 4.706e-233 734.0
HFD2_k127_1375408_1 SMART Elongator protein 3 MiaB NifB - - - 8.819e-212 685.0
HFD2_k127_1375408_10 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 509.0
HFD2_k127_1375408_11 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 466.0
HFD2_k127_1375408_12 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 436.0
HFD2_k127_1375408_13 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 435.0
HFD2_k127_1375408_14 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 424.0
HFD2_k127_1375408_15 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 410.0
HFD2_k127_1375408_16 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 382.0
HFD2_k127_1375408_17 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 359.0
HFD2_k127_1375408_18 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 331.0
HFD2_k127_1375408_19 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 300.0
HFD2_k127_1375408_2 Arginosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 7.225e-194 611.0
HFD2_k127_1375408_20 regulatory protein IclR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 294.0
HFD2_k127_1375408_21 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004464 276.0
HFD2_k127_1375408_22 PFAM ATP-binding region, ATPase domain protein K02668,K07708,K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003934 291.0
HFD2_k127_1375408_23 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001165 290.0
HFD2_k127_1375408_24 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002502 277.0
HFD2_k127_1375408_25 regulatory protein GntR HTH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000137 239.0
HFD2_k127_1375408_26 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000001248 239.0
HFD2_k127_1375408_27 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000001114 235.0
HFD2_k127_1375408_28 PFAM regulatory protein TetR K13770 - - 0.000000000000000000000000000000000000000000000000002532 189.0
HFD2_k127_1375408_29 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000001301 196.0
HFD2_k127_1375408_3 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 570.0
HFD2_k127_1375408_30 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000009302 183.0
HFD2_k127_1375408_31 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.0000000000000000000000000000000000000003894 165.0
HFD2_k127_1375408_32 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000001167 128.0
HFD2_k127_1375408_33 TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.000000000000000000000003126 118.0
HFD2_k127_1375408_34 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000003689 111.0
HFD2_k127_1375408_35 sigma factor antagonist activity K04757 - 2.7.11.1 0.0000000000000001405 94.0
HFD2_k127_1375408_36 transporter antisigma-factor antagonist STAS K04749,K06378 - - 0.000001671 55.0
HFD2_k127_1375408_4 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 559.0
HFD2_k127_1375408_5 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 550.0
HFD2_k127_1375408_6 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006091 550.0
HFD2_k127_1375408_7 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 527.0
HFD2_k127_1375408_8 Fe-S oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 531.0
HFD2_k127_1375408_9 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 512.0
HFD2_k127_1457029_0 Peptidase family U32 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 605.0
HFD2_k127_1457029_1 Chalcone and stilbene synthases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 438.0
HFD2_k127_1457029_10 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000003356 160.0
HFD2_k127_1457029_11 YceI-like domain - - - 0.00000000000000000000000000000003121 134.0
HFD2_k127_1457029_12 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000004167 126.0
HFD2_k127_1457029_13 Thioesterase superfamily - - - 0.0000000000000000000000000004403 128.0
HFD2_k127_1457029_14 Papain-like cysteine protease AvrRpt2 - - - 0.0000000000000000000000001807 115.0
HFD2_k127_1457029_15 Tetratricopeptide repeat - - - 0.0000000000000000000003414 110.0
HFD2_k127_1457029_16 Thioesterase K01075 - 3.1.2.23 0.000000000000000000003909 107.0
HFD2_k127_1457029_17 belongs to the Fur family K03711 - - 0.0000000000000001795 86.0
HFD2_k127_1457029_18 Putative zinc-finger - - - 0.0000000000005216 80.0
HFD2_k127_1457029_19 - - - - 0.000000004609 59.0
HFD2_k127_1457029_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 322.0
HFD2_k127_1457029_20 gas vesicle protein - - - 0.0000001192 57.0
HFD2_k127_1457029_3 SMART Elongator protein 3 MiaB NifB K07139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 314.0
HFD2_k127_1457029_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003419 279.0
HFD2_k127_1457029_5 penicillin-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001659 271.0
HFD2_k127_1457029_6 AAA domain, putative AbiEii toxin, Type IV TA system K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000002018 248.0
HFD2_k127_1457029_7 Zinc-uptake complex component A periplasmic K09815 - - 0.00000000000000000000000000000000000000000000000000000000424 215.0
HFD2_k127_1457029_8 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000005054 220.0
HFD2_k127_1457029_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000007998 155.0
HFD2_k127_1558304_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.134e-230 726.0
HFD2_k127_1558304_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 562.0
HFD2_k127_1558304_2 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 345.0
HFD2_k127_1558304_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 326.0
HFD2_k127_1558304_6 Polymer-forming cytoskeletal - - - 0.000000002365 61.0
HFD2_k127_1661891_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1140.0
HFD2_k127_1661891_1 4Fe-4S ferredoxin K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 293.0
HFD2_k127_1661891_2 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000002048 219.0
HFD2_k127_1661891_3 Mechanosensitive ion channel K03442 - - 0.00000000000000000000000000000000000000000000000000000001184 205.0
HFD2_k127_1661891_4 Polysulfide reductase - - - 0.0000000000000000000000000000000000000000000000000002657 212.0
HFD2_k127_1661891_5 PFAM Bacterial regulatory protein, Fis family K17763 - - 0.0000000000000000000000000000000000000000001626 182.0
HFD2_k127_1661891_6 photoreceptor activity K01120 - 3.1.4.17 0.00000000000000000000000000000000000000002081 175.0
HFD2_k127_1661891_7 Protein involved in formate dehydrogenase formation K02380 - - 0.000000000000000000000000000009129 134.0
HFD2_k127_1761276_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 2.413e-254 833.0
HFD2_k127_1761276_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 596.0
HFD2_k127_1761276_10 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000008416 271.0
HFD2_k127_1761276_11 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003738 261.0
HFD2_k127_1761276_12 4Fe-4S single cluster domain K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000005658 240.0
HFD2_k127_1761276_13 PFAM Isochorismatase K08281 - 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000811 211.0
HFD2_k127_1761276_14 Trypsin-like peptidase domain - - - 0.00000000000000000000000000000000000000000000000000001466 200.0
HFD2_k127_1761276_15 Catalyzes the transfer of a methyl group to L- homocysteine resulting in methionine formation. The physiological methyl donor is K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.0000000000000000000000000000000000000000000000000001736 202.0
HFD2_k127_1761276_16 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000001466 197.0
HFD2_k127_1761276_17 Magnesium chelatase, subunit ChlI K03404,K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000002311 173.0
HFD2_k127_1761276_18 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000003137 171.0
HFD2_k127_1761276_19 Base excision DNA repair protein, HhH-GPD family K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000003383 177.0
HFD2_k127_1761276_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 577.0
HFD2_k127_1761276_20 Major Facilitator - - - 0.000000000000000000000000000000000005269 152.0
HFD2_k127_1761276_21 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000001192 107.0
HFD2_k127_1761276_22 AsmA family - - - 0.000000000001412 81.0
HFD2_k127_1761276_23 Pfam:DUF1049 - - - 0.000008518 51.0
HFD2_k127_1761276_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 556.0
HFD2_k127_1761276_4 SMART ATPase, AAA type, core - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 499.0
HFD2_k127_1761276_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 432.0
HFD2_k127_1761276_6 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 409.0
HFD2_k127_1761276_7 THUMP K07444,K12297 - 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 398.0
HFD2_k127_1761276_8 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 399.0
HFD2_k127_1761276_9 Dimerisation domain of Zinc Transporter K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006629 269.0
HFD2_k127_1783386_0 Domain of unknown function (DUF3536) - - - 9.4e-320 1021.0
HFD2_k127_1783386_1 Alpha amylase, catalytic domain K06044 - 5.4.99.15 7.613e-313 985.0
HFD2_k127_1783386_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 2.417e-207 654.0
HFD2_k127_1783386_3 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 1.725e-199 633.0
HFD2_k127_1783386_4 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 321.0
HFD2_k127_1783386_5 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000222 241.0
HFD2_k127_1783386_7 BON domain - - - 0.0000000000000000000000000000000499 129.0
HFD2_k127_1783386_8 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000002197 54.0
HFD2_k127_1783386_9 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.00004633 46.0
HFD2_k127_1801930_0 associated with various cellular activities K03695,K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 524.0
HFD2_k127_1801930_1 Histidine kinase K10715,K20974 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 441.0
HFD2_k127_1801930_2 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 370.0
HFD2_k127_1801930_3 PFAM Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000001726 199.0
HFD2_k127_1801930_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000006686 118.0
HFD2_k127_1801930_5 cobalamin binding - - - 0.00005115 53.0
HFD2_k127_1816073_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1242.0
HFD2_k127_1816073_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1189.0
HFD2_k127_1816073_10 NeuB family K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 469.0
HFD2_k127_1816073_11 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 428.0
HFD2_k127_1816073_12 response regulator K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 399.0
HFD2_k127_1816073_13 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 380.0
HFD2_k127_1816073_14 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 367.0
HFD2_k127_1816073_15 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 329.0
HFD2_k127_1816073_16 carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 313.0
HFD2_k127_1816073_17 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 296.0
HFD2_k127_1816073_18 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 301.0
HFD2_k127_1816073_19 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000006971 261.0
HFD2_k127_1816073_2 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1176.0
HFD2_k127_1816073_20 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004414 258.0
HFD2_k127_1816073_21 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000142 249.0
HFD2_k127_1816073_22 PFAM Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001027 237.0
HFD2_k127_1816073_23 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000006422 244.0
HFD2_k127_1816073_24 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000206 193.0
HFD2_k127_1816073_25 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.00000000000000000000000000000000000000000000000007626 194.0
HFD2_k127_1816073_26 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000004488 198.0
HFD2_k127_1816073_27 HD domain - - - 0.0000000000000000000000000000000000000000000001668 194.0
HFD2_k127_1816073_28 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000001856 177.0
HFD2_k127_1816073_29 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000009122 158.0
HFD2_k127_1816073_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.214e-317 1013.0
HFD2_k127_1816073_30 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000002355 153.0
HFD2_k127_1816073_31 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000001153 160.0
HFD2_k127_1816073_32 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000006402 148.0
HFD2_k127_1816073_33 Single-strand binding protein family K03111 - - 0.00000000000000000000000000000000000001001 148.0
HFD2_k127_1816073_34 Universal stress protein K06149 - - 0.000000000000000000000000000000000003695 142.0
HFD2_k127_1816073_35 RES - - - 0.000000000000000000000000000000000006812 148.0
HFD2_k127_1816073_36 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000008 141.0
HFD2_k127_1816073_37 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000003956 147.0
HFD2_k127_1816073_38 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000002041 140.0
HFD2_k127_1816073_39 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000008655 119.0
HFD2_k127_1816073_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.017e-288 912.0
HFD2_k127_1816073_40 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000004437 115.0
HFD2_k127_1816073_41 Protein of unknown function (DUF2384) - - - 0.0000000000000000000000000005946 119.0
HFD2_k127_1816073_42 nucleic acid binding K01174 - 3.1.31.1 0.0000000000000000000000004736 117.0
HFD2_k127_1816073_43 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000001393 103.0
HFD2_k127_1816073_44 PIN domain - - - 0.00000000000000000000004634 105.0
HFD2_k127_1816073_45 GIY-YIG catalytic domain K07461 - - 0.000000000000000000001732 97.0
HFD2_k127_1816073_46 Pkd domain containing protein - - - 0.0000000000000000001354 95.0
HFD2_k127_1816073_47 Protein of unknown function (DUF507) - - - 0.000000000000000001592 90.0
HFD2_k127_1816073_48 Regulatory protein, FmdB family - - - 0.000000000000000002437 90.0
HFD2_k127_1816073_49 Protein of unknown function (DUF3047) - - - 0.00000000000000001475 84.0
HFD2_k127_1816073_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 5.682e-262 816.0
HFD2_k127_1816073_50 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000001689 85.0
HFD2_k127_1816073_51 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000001986 78.0
HFD2_k127_1816073_52 energy transducer activity K03832 - - 0.000000000000008766 85.0
HFD2_k127_1816073_54 Saccharopine dehydrogenase K00290 - 1.5.1.7 0.000000004255 68.0
HFD2_k127_1816073_55 - - - - 0.000002438 49.0
HFD2_k127_1816073_57 Protein of unknown function (DUF507) - - - 0.00001266 56.0
HFD2_k127_1816073_6 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009425 602.0
HFD2_k127_1816073_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 592.0
HFD2_k127_1816073_8 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 594.0
HFD2_k127_1816073_9 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 524.0
HFD2_k127_1830177_0 Aminotransferase K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 496.0
HFD2_k127_1830177_1 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 389.0
HFD2_k127_1830177_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000006007 184.0
HFD2_k127_1830177_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000001645 188.0
HFD2_k127_1830177_4 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000007548 170.0
HFD2_k127_1830177_5 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000001589 147.0
HFD2_k127_1848560_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 4.581e-219 690.0
HFD2_k127_1848560_1 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 2.144e-197 639.0
HFD2_k127_1848560_10 formate dehydrogenase (NAD+) activity K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 417.0
HFD2_k127_1848560_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 369.0
HFD2_k127_1848560_12 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 345.0
HFD2_k127_1848560_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000005575 227.0
HFD2_k127_1848560_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000008719 218.0
HFD2_k127_1848560_15 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000001027 218.0
HFD2_k127_1848560_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000005321 188.0
HFD2_k127_1848560_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000003313 181.0
HFD2_k127_1848560_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000001733 169.0
HFD2_k127_1848560_19 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000002992 181.0
HFD2_k127_1848560_2 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 6.635e-195 629.0
HFD2_k127_1848560_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000001933 147.0
HFD2_k127_1848560_21 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.000000000000000000000000000000000009566 139.0
HFD2_k127_1848560_22 PFAM peptidase U32 K08303 - - 0.00000000000000000000000000000000006443 148.0
HFD2_k127_1848560_23 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000119 136.0
HFD2_k127_1848560_24 thioesterase K07107 - - 0.000000000000000000000000000004504 123.0
HFD2_k127_1848560_25 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000001856 126.0
HFD2_k127_1848560_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000004508 110.0
HFD2_k127_1848560_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000001332 108.0
HFD2_k127_1848560_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000005628 105.0
HFD2_k127_1848560_29 - - - - 0.000000000003915 73.0
HFD2_k127_1848560_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 516.0
HFD2_k127_1848560_30 heat shock protein binding K03686,K04082,K05516 - - 0.00000000001192 70.0
HFD2_k127_1848560_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 516.0
HFD2_k127_1848560_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 474.0
HFD2_k127_1848560_6 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 450.0
HFD2_k127_1848560_7 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 449.0
HFD2_k127_1848560_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 434.0
HFD2_k127_1848560_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007865 421.0
HFD2_k127_1909804_0 Acetolactate synthase, large subunit K01652 - 2.2.1.6 1.142e-285 886.0
HFD2_k127_1909804_1 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 295.0
HFD2_k127_1909804_10 Aldo/keto reductase family - - - 0.000001225 51.0
HFD2_k127_1909804_11 - - - - 0.00001112 54.0
HFD2_k127_1909804_2 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001486 245.0
HFD2_k127_1909804_3 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000008135 238.0
HFD2_k127_1909804_4 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000375 231.0
HFD2_k127_1909804_5 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000007242 214.0
HFD2_k127_1909804_6 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000000000000000106 163.0
HFD2_k127_1909804_7 SnoaL-like polyketide cyclase - - - 0.000000000000006419 74.0
HFD2_k127_1909804_8 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.000000007071 57.0
HFD2_k127_1909804_9 Dehydrogenase K00004,K00008 - 1.1.1.14,1.1.1.303,1.1.1.4 0.00000002423 58.0
HFD2_k127_1943641_0 'glutamate synthase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 3.026e-216 682.0
HFD2_k127_1943641_1 Sugar (and other) transporter K08224 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 419.0
HFD2_k127_1943641_2 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000006332 233.0
HFD2_k127_1943641_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000009557 234.0
HFD2_k127_1943641_4 - - - - 0.0000000000000000000000000000000000000000000007705 181.0
HFD2_k127_1943641_5 - - - - 0.0000000000000000000000000000000000003371 145.0
HFD2_k127_1943641_6 Smr protein MutS2 - - - 0.00000000000001701 77.0
HFD2_k127_1943641_7 Dodecin K09165 - - 0.00000000001265 64.0
HFD2_k127_1943641_8 PFAM Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0000000003937 61.0
HFD2_k127_1943641_9 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000002462 52.0
HFD2_k127_1982768_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 309.0
HFD2_k127_1982768_1 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000001461 161.0
HFD2_k127_1982768_2 - - - - 0.000000000000000000000000000000000000000001966 172.0
HFD2_k127_1982768_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000001156 109.0
HFD2_k127_1982768_4 DoxX family K15977 - - 0.00000000000000000000005277 104.0
HFD2_k127_1982768_5 PFAM Methylene-tetrahydrofolate reductase C terminal - - - 0.000005126 52.0
HFD2_k127_20671_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.0 1090.0
HFD2_k127_20671_1 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 1.121e-287 891.0
HFD2_k127_20671_10 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 353.0
HFD2_k127_20671_11 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 339.0
HFD2_k127_20671_12 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 345.0
HFD2_k127_20671_13 PFAM filamentation induced by cAMP protein Fic - - - 0.00000000000000000000000000000000000000000000001446 184.0
HFD2_k127_20671_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000001638 182.0
HFD2_k127_20671_15 Protein of unknown function, DUF393 - - - 0.00000000000000000000000001421 116.0
HFD2_k127_20671_16 hydrogen uptake protein K03605 - - 0.000000000000000000000002702 117.0
HFD2_k127_20671_17 - - - - 0.000000000000000000000003377 107.0
HFD2_k127_20671_18 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000025 116.0
HFD2_k127_20671_19 Belongs to the universal stress protein A family - - - 0.00000000000000000000005928 105.0
HFD2_k127_20671_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 7.153e-212 672.0
HFD2_k127_20671_20 HupF/HypC family K04653 - - 0.0000000000000001138 85.0
HFD2_k127_20671_21 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000006677 70.0
HFD2_k127_20671_22 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000002734 65.0
HFD2_k127_20671_23 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000008228 76.0
HFD2_k127_20671_24 binding domain protein - - - 0.00000152 50.0
HFD2_k127_20671_25 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0005328 49.0
HFD2_k127_20671_3 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 7.476e-209 681.0
HFD2_k127_20671_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 591.0
HFD2_k127_20671_5 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 511.0
HFD2_k127_20671_6 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 495.0
HFD2_k127_20671_7 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 446.0
HFD2_k127_20671_8 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 406.0
HFD2_k127_20671_9 PFAM Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 364.0
HFD2_k127_2091258_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 571.0
HFD2_k127_2091258_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005896 560.0
HFD2_k127_2091258_10 PHB/PHA accumulation regulator DNA-binding domain - - - 0.00000000000000000000000000000000000001053 149.0
HFD2_k127_2091258_11 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0000000000000000000000000000000000007985 148.0
HFD2_k127_2091258_12 PFAM ROSMUCR transcriptional regulator - - - 0.0000000000000000000000000000002426 128.0
HFD2_k127_2091258_13 PFAM YbaK prolyl-tRNA synthetases associated domain - - - 0.0000000000000000000000001004 116.0
HFD2_k127_2091258_14 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000002523 114.0
HFD2_k127_2091258_15 - - - - 0.0000000000000000000001099 111.0
HFD2_k127_2091258_16 PFAM Phosphoglycerate mutase K08296 - - 0.000000000000000000007573 98.0
HFD2_k127_2091258_17 - - - - 0.0000000000000000001556 93.0
HFD2_k127_2091258_18 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.000002641 51.0
HFD2_k127_2091258_2 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 505.0
HFD2_k127_2091258_3 Two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 410.0
HFD2_k127_2091258_4 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 382.0
HFD2_k127_2091258_5 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 327.0
HFD2_k127_2091258_6 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 286.0
HFD2_k127_2091258_7 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 293.0
HFD2_k127_2091258_8 Metal-binding integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000812 259.0
HFD2_k127_2091258_9 Signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000006541 246.0
HFD2_k127_2096378_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 511.0
HFD2_k127_2096378_1 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008733 311.0
HFD2_k127_2096378_10 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000002967 177.0
HFD2_k127_2096378_11 COG1226 Kef-type K transport systems - - - 0.0000000000000000000000000000000003427 142.0
HFD2_k127_2096378_12 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000001392 102.0
HFD2_k127_2096378_2 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008771 295.0
HFD2_k127_2096378_3 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 291.0
HFD2_k127_2096378_4 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005329 267.0
HFD2_k127_2096378_5 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000003594 263.0
HFD2_k127_2096378_6 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000001615 246.0
HFD2_k127_2096378_7 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000003887 230.0
HFD2_k127_2096378_8 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000003353 207.0
HFD2_k127_2096378_9 ABC-type cobalamin Fe3 -siderophore transport system, ATPase component K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000004974 206.0
HFD2_k127_213075_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1177.0
HFD2_k127_213075_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.257e-272 850.0
HFD2_k127_213075_10 phenylalanine-tRNA ligase activity K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 420.0
HFD2_k127_213075_11 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 383.0
HFD2_k127_213075_12 Protein of unknown function (DUF512) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 351.0
HFD2_k127_213075_13 Ferrous iron transport protein B K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 345.0
HFD2_k127_213075_14 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 287.0
HFD2_k127_213075_15 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 286.0
HFD2_k127_213075_16 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002354 305.0
HFD2_k127_213075_17 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004958 279.0
HFD2_k127_213075_18 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003286 283.0
HFD2_k127_213075_19 GTP-binding GTPase Middle Region K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002826 289.0
HFD2_k127_213075_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 4.471e-248 779.0
HFD2_k127_213075_20 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000006254 204.0
HFD2_k127_213075_21 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000002441 194.0
HFD2_k127_213075_22 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000001835 170.0
HFD2_k127_213075_23 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000001255 151.0
HFD2_k127_213075_24 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000003654 153.0
HFD2_k127_213075_25 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000000000431 139.0
HFD2_k127_213075_26 Transcriptional regulator K13643 - - 0.0000000000000000000000000000000469 133.0
HFD2_k127_213075_27 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000001613 133.0
HFD2_k127_213075_28 - - - - 0.000000000000000000000000000391 127.0
HFD2_k127_213075_29 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000001035 109.0
HFD2_k127_213075_3 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 5.082e-213 672.0
HFD2_k127_213075_30 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000004582 76.0
HFD2_k127_213075_31 YbbR-like protein - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.0000000005713 68.0
HFD2_k127_213075_32 - - - - 0.000000005181 64.0
HFD2_k127_213075_33 competence protein ComEA helix-hairpin-helix repeat protein K02237 - - 0.00001069 55.0
HFD2_k127_213075_34 Virulence factor BrkB K07058 - - 0.00007733 56.0
HFD2_k127_213075_4 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.312e-211 669.0
HFD2_k127_213075_5 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 572.0
HFD2_k127_213075_6 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 564.0
HFD2_k127_213075_7 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 463.0
HFD2_k127_213075_8 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 444.0
HFD2_k127_213075_9 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 441.0
HFD2_k127_223076_0 Enoyl-CoA hydratase/isomerase K14469 - 1.3.1.84,4.2.1.116,6.2.1.36 0.000000000000000000000000000002037 143.0
HFD2_k127_223076_1 protocatechuate 3,4-dioxygenase activity K03381 - 1.13.11.1 0.000000000000000000000000003314 121.0
HFD2_k127_223076_2 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000007738 114.0
HFD2_k127_223076_3 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000001434 90.0
HFD2_k127_223076_4 - - - - 0.00000000000001526 77.0
HFD2_k127_223076_5 PFAM Integral membrane protein TerC - - - 0.00000000000002827 73.0
HFD2_k127_223076_6 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000000000001999 83.0
HFD2_k127_223076_7 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000346 82.0
HFD2_k127_223076_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0003328 44.0
HFD2_k127_2339991_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 6.477e-244 778.0
HFD2_k127_2339991_1 BadF/BadG/BcrA/BcrD ATPase family - - - 3.705e-224 701.0
HFD2_k127_2339991_10 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 380.0
HFD2_k127_2339991_11 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 379.0
HFD2_k127_2339991_12 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 301.0
HFD2_k127_2339991_13 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 292.0
HFD2_k127_2339991_14 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003765 253.0
HFD2_k127_2339991_15 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000002981 229.0
HFD2_k127_2339991_16 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000005983 214.0
HFD2_k127_2339991_17 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000003169 211.0
HFD2_k127_2339991_2 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 5.075e-221 707.0
HFD2_k127_2339991_3 Enoyl-CoA hydratase/isomerase K07539 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 8.08e-216 675.0
HFD2_k127_2339991_4 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 3.385e-211 678.0
HFD2_k127_2339991_5 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 541.0
HFD2_k127_2339991_6 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 475.0
HFD2_k127_2339991_7 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 446.0
HFD2_k127_2339991_8 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 401.0
HFD2_k127_2339991_9 KR domain K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 376.0
HFD2_k127_2660650_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.545e-223 719.0
HFD2_k127_2660650_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 4.376e-216 691.0
HFD2_k127_2660650_10 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000001223 234.0
HFD2_k127_2660650_11 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000279 237.0
HFD2_k127_2660650_12 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000001131 200.0
HFD2_k127_2660650_13 protein conserved in bacteria K09798 - - 0.000000000000000000000000000001802 132.0
HFD2_k127_2660650_14 LysM domain - - - 0.00000000000000000000004899 112.0
HFD2_k127_2660650_15 - - - - 0.0000000000000000000005428 105.0
HFD2_k127_2660650_16 ATPases associated with a variety of cellular activities - - - 0.00000000000000007276 89.0
HFD2_k127_2660650_17 Peptidase family M23 K21471 - - 0.00000000000002508 87.0
HFD2_k127_2660650_18 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000002127 72.0
HFD2_k127_2660650_19 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000001858 68.0
HFD2_k127_2660650_2 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 2.167e-206 663.0
HFD2_k127_2660650_20 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.00001172 58.0
HFD2_k127_2660650_3 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 445.0
HFD2_k127_2660650_4 response regulator K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 414.0
HFD2_k127_2660650_5 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009382 407.0
HFD2_k127_2660650_6 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 347.0
HFD2_k127_2660650_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 308.0
HFD2_k127_2660650_8 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001015 265.0
HFD2_k127_2660650_9 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000001734 246.0
HFD2_k127_2663076_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1062.0
HFD2_k127_2663076_1 Carbamoyl-phosphate synthetase large chain domain protein K01959,K01961 - 6.3.4.14,6.4.1.1,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 584.0
HFD2_k127_2663076_10 surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 331.0
HFD2_k127_2663076_11 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 314.0
HFD2_k127_2663076_12 ABC transporter, ATP-binding protein K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001642 280.0
HFD2_k127_2663076_13 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001708 271.0
HFD2_k127_2663076_14 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002383 273.0
HFD2_k127_2663076_15 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000005461 254.0
HFD2_k127_2663076_16 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000002715 263.0
HFD2_k127_2663076_17 histidine kinase, HAMP - - - 0.000000000000000000000000000000000000000000000000000000000000001358 237.0
HFD2_k127_2663076_18 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000001038 242.0
HFD2_k127_2663076_19 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000006049 226.0
HFD2_k127_2663076_2 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 585.0
HFD2_k127_2663076_20 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000001073 194.0
HFD2_k127_2663076_21 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000005964 205.0
HFD2_k127_2663076_22 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000005767 173.0
HFD2_k127_2663076_23 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000003453 184.0
HFD2_k127_2663076_24 PFAM Pilus assembly protein PilO K02664 - - 0.000000000000000000000000000000000000000003298 162.0
HFD2_k127_2663076_25 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000005588 173.0
HFD2_k127_2663076_26 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000001081 150.0
HFD2_k127_2663076_27 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000001155 154.0
HFD2_k127_2663076_28 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000007052 140.0
HFD2_k127_2663076_29 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000004082 136.0
HFD2_k127_2663076_3 Aminotransferase K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 484.0
HFD2_k127_2663076_30 response regulator - - - 0.000000000000000000000000000000000456 145.0
HFD2_k127_2663076_31 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000003894 132.0
HFD2_k127_2663076_32 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000003015 136.0
HFD2_k127_2663076_33 ATP-binding region ATPase domain protein, response regulator receiver, histidine kinase A domain protein - - - 0.0000000000000000000000003751 115.0
HFD2_k127_2663076_34 Pilus assembly protein, PilP K02665 - - 0.000000000000000000003563 100.0
HFD2_k127_2663076_35 Fimbrial assembly protein (PilN) K02663 - - 0.00000000000000000001896 99.0
HFD2_k127_2663076_36 Domain of unknown function (DUF1858) - - - 0.0000000000000000002499 89.0
HFD2_k127_2663076_37 PFAM helix-turn-helix domain protein - - - 0.00000000000000001726 86.0
HFD2_k127_2663076_38 Outer membrane efflux protein - - - 0.000000000000000139 94.0
HFD2_k127_2663076_39 membrane protein domain - - - 0.0000000000008483 74.0
HFD2_k127_2663076_4 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 461.0
HFD2_k127_2663076_40 Tetratricopeptide repeats - - - 0.0000000004632 72.0
HFD2_k127_2663076_41 Roadblock/LC7 domain - - - 0.000003922 57.0
HFD2_k127_2663076_5 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 441.0
HFD2_k127_2663076_6 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 407.0
HFD2_k127_2663076_7 type IV pilus secretin PilQ K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 428.0
HFD2_k127_2663076_8 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 403.0
HFD2_k127_2663076_9 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 323.0
HFD2_k127_2693179_0 FAD-dependent dehydrogenases - - - 1.289e-197 625.0
HFD2_k127_2693179_1 Rod shape-determining protein K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 513.0
HFD2_k127_2693179_10 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.00000000000000000000000000000000000000001028 168.0
HFD2_k127_2693179_11 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000005488 159.0
HFD2_k127_2693179_12 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000007817 158.0
HFD2_k127_2693179_13 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000001251 136.0
HFD2_k127_2693179_14 diguanylate cyclase activity K02000,K04767,K05847,K07168,K09137 - 3.6.3.32 0.0000000000000000000000000000007841 130.0
HFD2_k127_2693179_15 phage terminase small subunit - - - 0.00000000000000000000001203 104.0
HFD2_k127_2693179_16 Protein of unknown function (DUF1376) - - - 0.0000000000000004025 89.0
HFD2_k127_2693179_2 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 470.0
HFD2_k127_2693179_3 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 439.0
HFD2_k127_2693179_4 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 337.0
HFD2_k127_2693179_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006748 334.0
HFD2_k127_2693179_6 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 321.0
HFD2_k127_2693179_7 Phage capsid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001744 284.0
HFD2_k127_2693179_8 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000002168 243.0
HFD2_k127_2693179_9 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000002256 217.0
HFD2_k127_2709163_0 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 5.36e-225 703.0
HFD2_k127_2709163_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 416.0
HFD2_k127_2709163_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000003939 258.0
HFD2_k127_2709163_3 Protein of unknown function (DUF3455) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002566 248.0
HFD2_k127_2709163_4 - - - - 0.000000000000000000000000000000000000000001333 167.0
HFD2_k127_2709163_5 Domain of unknown function (DUF1820) - - - 0.000000000000000000000000000000004035 132.0
HFD2_k127_2709163_6 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000426 94.0
HFD2_k127_2709163_7 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000004538 91.0
HFD2_k127_2765486_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1031.0
HFD2_k127_2765486_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 499.0
HFD2_k127_2765486_10 adenylylsulfate kinase activity K00860,K00955 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000004854 157.0
HFD2_k127_2765486_11 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000000000000001377 150.0
HFD2_k127_2765486_12 FecR protein - - - 0.00000000000000000000000000000000000003352 163.0
HFD2_k127_2765486_13 Domain of unknown function (DUF1992) - - - 0.00000000000000000000000000000000000007841 151.0
HFD2_k127_2765486_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000002312 145.0
HFD2_k127_2765486_15 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.000000000000000000000000009808 126.0
HFD2_k127_2765486_16 Transcriptional regulator - - - 0.0000000000000000006318 90.0
HFD2_k127_2765486_17 - - - - 0.00000000000006224 78.0
HFD2_k127_2765486_18 - - - - 0.0000000000004659 78.0
HFD2_k127_2765486_2 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 392.0
HFD2_k127_2765486_3 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 376.0
HFD2_k127_2765486_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000003484 255.0
HFD2_k127_2765486_5 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000001356 230.0
HFD2_k127_2765486_6 PFAM Appr-1-p processing - - - 0.000000000000000000000000000000000000000000000000000001479 218.0
HFD2_k127_2765486_7 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000005265 188.0
HFD2_k127_2765486_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000004438 169.0
HFD2_k127_2765486_9 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000001818 182.0
HFD2_k127_2776195_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.06e-198 631.0
HFD2_k127_2776195_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 586.0
HFD2_k127_2776195_10 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 380.0
HFD2_k127_2776195_11 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 378.0
HFD2_k127_2776195_12 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 387.0
HFD2_k127_2776195_13 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 374.0
HFD2_k127_2776195_14 Conserved protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 354.0
HFD2_k127_2776195_15 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006645 342.0
HFD2_k127_2776195_16 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 333.0
HFD2_k127_2776195_17 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 334.0
HFD2_k127_2776195_18 ATPase associated with various cellular K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 303.0
HFD2_k127_2776195_19 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 308.0
HFD2_k127_2776195_2 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006354 578.0
HFD2_k127_2776195_20 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 305.0
HFD2_k127_2776195_21 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000476 279.0
HFD2_k127_2776195_22 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002434 256.0
HFD2_k127_2776195_23 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003058 265.0
HFD2_k127_2776195_24 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007506 249.0
HFD2_k127_2776195_25 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000001916 244.0
HFD2_k127_2776195_26 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000004984 214.0
HFD2_k127_2776195_27 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K13566 - 3.5.1.3 0.00000000000000000000000000000000000000000000000000000000001494 226.0
HFD2_k127_2776195_28 N,N-dimethylaniline monooxygenase activity K07222 - - 0.00000000000000000000000000000000000000000000000000003228 200.0
HFD2_k127_2776195_29 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000907 214.0
HFD2_k127_2776195_3 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 548.0
HFD2_k127_2776195_30 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000168 181.0
HFD2_k127_2776195_31 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000005391 192.0
HFD2_k127_2776195_32 - - - - 0.0000000000000000000000000000000000000000000001429 186.0
HFD2_k127_2776195_33 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000002881 177.0
HFD2_k127_2776195_34 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000009 164.0
HFD2_k127_2776195_35 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000002204 162.0
HFD2_k127_2776195_36 metallopeptidase activity K03630 - - 0.0000000000000000000000000000000000000001086 157.0
HFD2_k127_2776195_37 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000000000000000001227 169.0
HFD2_k127_2776195_38 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000003148 155.0
HFD2_k127_2776195_39 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000001495 147.0
HFD2_k127_2776195_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 544.0
HFD2_k127_2776195_40 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000008192 141.0
HFD2_k127_2776195_41 Ribosomal L27 protein K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000513 132.0
HFD2_k127_2776195_42 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000001019 136.0
HFD2_k127_2776195_43 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000002633 136.0
HFD2_k127_2776195_44 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000002702 123.0
HFD2_k127_2776195_45 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K20866 - 3.1.3.10 0.000000000000000000000000000005497 139.0
HFD2_k127_2776195_46 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000004664 129.0
HFD2_k127_2776195_47 Protein of unknown function DUF58 - - - 0.0000000000000000000000000007414 130.0
HFD2_k127_2776195_48 Phosphoribosyl transferase domain - - - 0.000000000000000000000000009288 121.0
HFD2_k127_2776195_49 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000001355 113.0
HFD2_k127_2776195_5 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005059 509.0
HFD2_k127_2776195_50 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000002916 96.0
HFD2_k127_2776195_51 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000508 89.0
HFD2_k127_2776195_52 - - - - 0.00000000000004481 75.0
HFD2_k127_2776195_53 Protein of unknown function (DUF3343) - - - 0.00000000001486 68.0
HFD2_k127_2776195_54 COG2104 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.000000000032 74.0
HFD2_k127_2776195_55 Protein of unknown function (DUF721) - - - 0.00000001159 64.0
HFD2_k127_2776195_56 E-Z type HEAT repeats - - - 0.0002017 51.0
HFD2_k127_2776195_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 484.0
HFD2_k127_2776195_7 Iron-only hydrogenase maturation rSAM protein HydG K03150 - 4.1.99.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 415.0
HFD2_k127_2776195_8 chelatase subunit ChlI K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 432.0
HFD2_k127_2776195_9 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 397.0
HFD2_k127_2812817_0 Radical SAM K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007872 458.0
HFD2_k127_2812817_1 E1-E2 ATPase K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 345.0
HFD2_k127_2812817_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 319.0
HFD2_k127_2812817_3 ATP-dependent DNA helicase activity K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002261 302.0
HFD2_k127_2812817_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001428 250.0
HFD2_k127_2812817_5 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.000000000000000000000000000000000000000000000000000000005763 222.0
HFD2_k127_2812817_6 Helix-turn-helix domain - - - 0.0000000000000000000000000000000001673 139.0
HFD2_k127_2812817_7 acetyltransferase K18815 - 2.3.1.82 0.00000000000000000000000000000004231 142.0
HFD2_k127_2812817_8 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000001641 124.0
HFD2_k127_2812817_9 exonuclease activity K16899 - 3.6.4.12 0.0000000000000000000000000006786 133.0
HFD2_k127_2818258_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 4.628e-253 788.0
HFD2_k127_2818258_1 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 582.0
HFD2_k127_2818258_2 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 608.0
HFD2_k127_2818258_3 FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 487.0
HFD2_k127_2818258_4 4Fe-4S dicluster domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000003463 252.0
HFD2_k127_2818258_5 Biotin-requiring enzyme - - - 0.00000000000000000000000000009767 126.0
HFD2_k127_2818258_6 Alpha beta hydrolase - - - 0.00000000008981 63.0
HFD2_k127_2823655_0 Signal peptide binding domain K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 548.0
HFD2_k127_2823655_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 481.0
HFD2_k127_2823655_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000005343 184.0
HFD2_k127_2823655_11 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000001507 182.0
HFD2_k127_2823655_12 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000003375 195.0
HFD2_k127_2823655_13 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000000006927 157.0
HFD2_k127_2823655_14 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000001506 149.0
HFD2_k127_2823655_15 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000113 116.0
HFD2_k127_2823655_16 RDD family - - - 0.00000000000000000000000203 108.0
HFD2_k127_2823655_17 Cell surface protein - - - 0.00000000000000000000000292 120.0
HFD2_k127_2823655_18 SpoVT / AbrB like domain - - - 0.0000000000000000000005473 96.0
HFD2_k127_2823655_19 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000009274 96.0
HFD2_k127_2823655_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 460.0
HFD2_k127_2823655_20 Belongs to the UPF0102 family K07460 - - 0.0000000000000000007642 90.0
HFD2_k127_2823655_21 NADPH-dependent FMN reductase K19784 - - 0.000000000000002608 75.0
HFD2_k127_2823655_22 - - - - 0.0006584 46.0
HFD2_k127_2823655_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 452.0
HFD2_k127_2823655_4 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 437.0
HFD2_k127_2823655_5 Peptidase dimerisation domain K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 373.0
HFD2_k127_2823655_6 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000006493 264.0
HFD2_k127_2823655_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004214 269.0
HFD2_k127_2823655_8 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000004136 213.0
HFD2_k127_2823655_9 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000000000000000000000000001097 211.0
HFD2_k127_2838347_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1073.0
HFD2_k127_2838347_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.69e-273 882.0
HFD2_k127_2838347_10 peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.0000000000000812 83.0
HFD2_k127_2838347_11 Transcriptional regulatory protein, C terminal - - - 0.0000000006944 61.0
HFD2_k127_2838347_12 Tetratricopeptide repeat protein - - - 0.0000744 57.0
HFD2_k127_2838347_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 377.0
HFD2_k127_2838347_3 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 322.0
HFD2_k127_2838347_4 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009272 312.0
HFD2_k127_2838347_5 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000003777 188.0
HFD2_k127_2838347_6 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000007878 139.0
HFD2_k127_2838347_7 PIN domain - - - 0.0000000000000000000000000000000001395 137.0
HFD2_k127_2838347_8 SpoVT / AbrB like domain - - - 0.0000000000000000002839 91.0
HFD2_k127_2838347_9 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.00000000000000173 87.0
HFD2_k127_2842835_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 1.046e-199 628.0
HFD2_k127_2842835_1 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 595.0
HFD2_k127_2842835_10 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000004014 228.0
HFD2_k127_2842835_11 - - - - 0.0000000000000000000000000000000000000000000000000000113 196.0
HFD2_k127_2842835_12 - - - - 0.00000000000000000000000000000000000000000000004111 179.0
HFD2_k127_2842835_13 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000000008659 171.0
HFD2_k127_2842835_14 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672,K21579 - 1.21.4.2,1.21.4.4 0.0000000000000000000000000000000004558 132.0
HFD2_k127_2842835_15 In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.00000000000000000000001447 103.0
HFD2_k127_2842835_16 Thioredoxin - - - 0.00000000000000005698 85.0
HFD2_k127_2842835_17 snoRNA binding - - - 0.00000001375 63.0
HFD2_k127_2842835_18 Putative MetA-pathway of phenol degradation - - - 0.00000003031 56.0
HFD2_k127_2842835_19 Glycine reductase complex selenoprotein A K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0004828 44.0
HFD2_k127_2842835_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K21577 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 537.0
HFD2_k127_2842835_3 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 510.0
HFD2_k127_2842835_4 PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits K10671 - 1.21.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 435.0
HFD2_k127_2842835_5 Glycine reductase complex component B subunit gamma K10672 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008978 417.0
HFD2_k127_2842835_6 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 379.0
HFD2_k127_2842835_7 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006623 402.0
HFD2_k127_2842835_8 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 384.0
HFD2_k127_2842835_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000003872 230.0
HFD2_k127_2849934_0 PFAM Type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 553.0
HFD2_k127_2849934_1 PFAM response regulator receiver K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 552.0
HFD2_k127_2849934_10 Glycine cleavage H-protein - - - 0.000000000000000000000000000000000000000000000076 177.0
HFD2_k127_2849934_11 metallopeptidase activity K06974 - - 0.0000000000000000000000000000000000000004961 154.0
HFD2_k127_2849934_12 PFAM General secretion pathway protein K K02460 - - 0.00000000000000000000000000000000004184 153.0
HFD2_k127_2849934_13 Transcription factor zinc-finger K09981 - - 0.0000000000000000000000000002476 117.0
HFD2_k127_2849934_14 Glycine cleavage H-protein - - - 0.000000000000000000000000005653 121.0
HFD2_k127_2849934_15 Glycine cleavage H-protein - - - 0.000000000000000000000000844 113.0
HFD2_k127_2849934_17 General secretion pathway protein K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.00000000000000568 87.0
HFD2_k127_2849934_18 General secretion pathway protein C K02452 - - 0.0000000000001697 81.0
HFD2_k127_2849934_19 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.0000008316 61.0
HFD2_k127_2849934_2 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 477.0
HFD2_k127_2849934_20 general secretion pathway protein K02456,K02457,K02458,K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000004184 54.0
HFD2_k127_2849934_22 Prokaryotic N-terminal methylation motif K02457 - - 0.00003212 55.0
HFD2_k127_2849934_3 Type II and III secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 438.0
HFD2_k127_2849934_4 HAMP domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 408.0
HFD2_k127_2849934_5 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 315.0
HFD2_k127_2849934_6 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002844 291.0
HFD2_k127_2849934_7 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000002507 236.0
HFD2_k127_2849934_8 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000001366 194.0
HFD2_k127_2849934_9 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000000004105 198.0
HFD2_k127_31807_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 568.0
HFD2_k127_31807_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 443.0
HFD2_k127_31807_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 321.0
HFD2_k127_31807_3 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003488 274.0
HFD2_k127_31807_4 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000121 109.0
HFD2_k127_31807_5 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000004315 101.0
HFD2_k127_31807_6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000134 100.0
HFD2_k127_3193660_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 6.557e-285 897.0
HFD2_k127_3193660_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 5.912e-249 784.0
HFD2_k127_3193660_10 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 334.0
HFD2_k127_3193660_11 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 310.0
HFD2_k127_3193660_12 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 306.0
HFD2_k127_3193660_13 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003025 284.0
HFD2_k127_3193660_14 Histidine kinase A domain protein K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009995 300.0
HFD2_k127_3193660_15 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000002571 240.0
HFD2_k127_3193660_16 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000003736 255.0
HFD2_k127_3193660_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000008994 172.0
HFD2_k127_3193660_18 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000000005642 164.0
HFD2_k127_3193660_19 EVE domain - - - 0.00000000000000000000000000000000000000001062 160.0
HFD2_k127_3193660_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 4.881e-247 781.0
HFD2_k127_3193660_20 Cobalamin biosynthesis protein cbiG - - - 0.00000000000000000000000000000000000000001411 166.0
HFD2_k127_3193660_21 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000004129 128.0
HFD2_k127_3193660_22 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000001734 120.0
HFD2_k127_3193660_23 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000004597 121.0
HFD2_k127_3193660_24 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000000000006605 113.0
HFD2_k127_3193660_25 Two component transcriptional regulator, winged helix family K02483,K07657 - - 0.00000000000000000005969 91.0
HFD2_k127_3193660_26 cheY-homologous receiver domain - - - 0.0000000000000000001675 94.0
HFD2_k127_3193660_27 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000557 89.0
HFD2_k127_3193660_28 Ribosomal protein L34 K02914 - - 0.0000000000001196 72.0
HFD2_k127_3193660_29 Magnesium chelatase, subunit ChlI K03404,K03405 - 6.6.1.1 0.0000000000006473 69.0
HFD2_k127_3193660_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.248e-242 763.0
HFD2_k127_3193660_30 ATP synthase B/B' CF(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000009098 70.0
HFD2_k127_3193660_31 domain, Protein - - - 0.00000000237 70.0
HFD2_k127_3193660_32 Putative zinc-finger - - - 0.00000007397 64.0
HFD2_k127_3193660_33 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000008603 63.0
HFD2_k127_3193660_34 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000006183 58.0
HFD2_k127_3193660_4 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 4.146e-233 759.0
HFD2_k127_3193660_5 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 548.0
HFD2_k127_3193660_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 477.0
HFD2_k127_3193660_7 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 481.0
HFD2_k127_3193660_8 Nucleotidyl transferase K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 404.0
HFD2_k127_3193660_9 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 381.0
HFD2_k127_3249514_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1041.0
HFD2_k127_3249514_1 Citrate lyase, alpha subunit (CitF) - - - 1.774e-275 863.0
HFD2_k127_3249514_10 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 364.0
HFD2_k127_3249514_11 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 346.0
HFD2_k127_3249514_12 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K09699 - 2.3.1.12,2.3.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 348.0
HFD2_k127_3249514_13 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 321.0
HFD2_k127_3249514_14 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 302.0
HFD2_k127_3249514_15 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 308.0
HFD2_k127_3249514_16 RecF/RecN/SMC N terminal domain K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 304.0
HFD2_k127_3249514_17 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 297.0
HFD2_k127_3249514_18 Amino acid amide ABC transporter ATP-binding protein 1, HAAT family K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 287.0
HFD2_k127_3249514_19 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000118 284.0
HFD2_k127_3249514_2 PFAM Aldehyde dehydrogenase - - - 2.928e-242 755.0
HFD2_k127_3249514_20 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000000000000000000000000000000000000000000000000000003096 207.0
HFD2_k127_3249514_21 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000659 191.0
HFD2_k127_3249514_22 Transketolase, pyrimidine binding domain K00167,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000001016 171.0
HFD2_k127_3249514_23 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000004998 182.0
HFD2_k127_3249514_24 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000005235 173.0
HFD2_k127_3249514_25 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.0000000000000000000000000000000000000001664 163.0
HFD2_k127_3249514_26 Could be involved in septation K06412 - - 0.000000000000000000000000000001357 123.0
HFD2_k127_3249514_27 Divergent 4Fe-4S mono-cluster K05337 - - 0.000000000000000000004157 95.0
HFD2_k127_3249514_28 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K14534 - 4.2.1.120,5.3.3.3 0.0000000000003999 71.0
HFD2_k127_3249514_29 Domain of unknown function (DUF1844) - - - 0.00000000006166 65.0
HFD2_k127_3249514_3 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 529.0
HFD2_k127_3249514_30 - - - - 0.0005539 53.0
HFD2_k127_3249514_4 AAA ATPase, central domain protein K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 490.0
HFD2_k127_3249514_5 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003697 490.0
HFD2_k127_3249514_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 483.0
HFD2_k127_3249514_7 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 454.0
HFD2_k127_3249514_8 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 430.0
HFD2_k127_3249514_9 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 391.0
HFD2_k127_3300979_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 564.0
HFD2_k127_3300979_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 535.0
HFD2_k127_3300979_2 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003723 295.0
HFD2_k127_3300979_3 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000004156 251.0
HFD2_k127_3300979_4 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000001482 182.0
HFD2_k127_3300979_5 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000168 183.0
HFD2_k127_3300979_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000001271 169.0
HFD2_k127_3300979_7 transglycosylase K08309 - - 0.0000000000000000000000001799 124.0
HFD2_k127_3300979_8 Xylose isomerase-like TIM barrel - - - 0.00000000000000000003441 101.0
HFD2_k127_3425499_0 1,4-alpha-glucan branching enzyme activity K00700,K01236 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18,3.2.1.141 0.0 1032.0
HFD2_k127_3425499_1 GTP-binding protein TypA K06207 - - 6.555e-251 793.0
HFD2_k127_3425499_10 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 330.0
HFD2_k127_3425499_11 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 342.0
HFD2_k127_3425499_12 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K01784,K10011 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 310.0
HFD2_k127_3425499_13 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 310.0
HFD2_k127_3425499_14 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006863 257.0
HFD2_k127_3425499_15 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002799 253.0
HFD2_k127_3425499_16 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000002498 207.0
HFD2_k127_3425499_17 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000003254 186.0
HFD2_k127_3425499_18 - - - - 0.0000000000000000000000000000000000002094 158.0
HFD2_k127_3425499_19 domain protein - - - 0.00000000000000000000000000000242 132.0
HFD2_k127_3425499_2 PFAM Polysulphide reductase, NrfD K00185 - - 3.183e-215 679.0
HFD2_k127_3425499_20 Calcineurin-like phosphoesterase - - - 0.00000000000000000001559 101.0
HFD2_k127_3425499_21 Rubrerythrin - - - 0.0000003437 59.0
HFD2_k127_3425499_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 565.0
HFD2_k127_3425499_4 PFAM 4Fe-4S K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 496.0
HFD2_k127_3425499_5 3-beta hydroxysteroid dehydrogenase/isomerase family K10011,K12449 - 1.1.1.305,2.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 472.0
HFD2_k127_3425499_6 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 442.0
HFD2_k127_3425499_7 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 385.0
HFD2_k127_3425499_8 4Fe-4S binding domain K08358 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 376.0
HFD2_k127_3425499_9 PFAM glycosyl transferase family 39 K07264 - 2.4.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 378.0
HFD2_k127_345775_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 2.311e-227 725.0
HFD2_k127_345775_1 Elongation factor Tu GTP binding domain K00956 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 612.0
HFD2_k127_345775_10 unfolded protein binding K04083 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 335.0
HFD2_k127_345775_11 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 300.0
HFD2_k127_345775_12 Domains HisKA, HATPase_c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001605 259.0
HFD2_k127_345775_13 Uncharacterized small protein (DUF2292) - - - 0.0000002356 53.0
HFD2_k127_345775_2 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 514.0
HFD2_k127_345775_3 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 521.0
HFD2_k127_345775_4 TIGRFAM sulfate adenylyltransferase, small subunit K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 440.0
HFD2_k127_345775_5 Sigma-54 interaction domain K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 440.0
HFD2_k127_345775_6 Binding-protein-dependent transport system inner membrane component K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 431.0
HFD2_k127_345775_7 Binding-protein-dependent transport system inner membrane component K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 405.0
HFD2_k127_345775_8 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 363.0
HFD2_k127_345775_9 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 341.0
HFD2_k127_349522_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.038e-209 665.0
HFD2_k127_349522_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.905e-198 625.0
HFD2_k127_349522_10 Domain of unknown function (DUF4124) K08309 - - 0.0000000000000000000000000000000000000000000000003533 181.0
HFD2_k127_349522_11 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000008136 158.0
HFD2_k127_349522_12 - - - - 0.0000000000000000000000000000000002806 135.0
HFD2_k127_349522_13 - - - - 0.0000000000000001124 88.0
HFD2_k127_349522_15 AIR synthase related protein, C-terminal domain K01952 - 6.3.5.3 0.0004828 44.0
HFD2_k127_349522_2 Glycosyltransferase Family 4 K08256 - 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 478.0
HFD2_k127_349522_3 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 396.0
HFD2_k127_349522_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 388.0
HFD2_k127_349522_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 342.0
HFD2_k127_349522_6 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 325.0
HFD2_k127_349522_7 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 319.0
HFD2_k127_349522_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000001137 215.0
HFD2_k127_349522_9 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.000000000000000000000000000000000000000000000000001589 187.0
HFD2_k127_3523960_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0 1024.0
HFD2_k127_3523960_1 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 607.0
HFD2_k127_3523960_10 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 409.0
HFD2_k127_3523960_11 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 390.0
HFD2_k127_3523960_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 348.0
HFD2_k127_3523960_13 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 342.0
HFD2_k127_3523960_14 uridine phosphorylase activity K00757 - 2.4.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 334.0
HFD2_k127_3523960_15 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 321.0
HFD2_k127_3523960_16 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 301.0
HFD2_k127_3523960_17 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 296.0
HFD2_k127_3523960_18 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 291.0
HFD2_k127_3523960_19 Belongs to the ABC transporter superfamily K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001164 299.0
HFD2_k127_3523960_2 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 607.0
HFD2_k127_3523960_20 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000005445 249.0
HFD2_k127_3523960_21 Extracellular solute-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000008253 231.0
HFD2_k127_3523960_22 sulfate transport system, permease K02047 - - 0.000000000000000000000000000000000000000000000000003197 194.0
HFD2_k127_3523960_23 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000000000000000004667 183.0
HFD2_k127_3523960_24 Histidine kinase K07709 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.000000000000000000000000000000000000000001105 174.0
HFD2_k127_3523960_25 DNA-binding transcription factor activity K03892 - - 0.00000000000000000000000000000000000005338 145.0
HFD2_k127_3523960_26 PFAM FeoA family protein K04758 - - 0.0000000000000000000000000000003609 123.0
HFD2_k127_3523960_27 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.000000000000000000000000000006548 123.0
HFD2_k127_3523960_28 - - - - 0.000000000000000000000000001106 121.0
HFD2_k127_3523960_29 PIN domain - - - 0.000000000000000000000000001447 118.0
HFD2_k127_3523960_3 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 578.0
HFD2_k127_3523960_30 Transcriptional regulator - - - 0.00000000000000000000000003145 113.0
HFD2_k127_3523960_31 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K16168 - - 0.0000000000000000000008254 95.0
HFD2_k127_3523960_32 - - - - 0.00000000000000003919 88.0
HFD2_k127_3523960_33 cellulase activity - - - 0.00000000000000183 90.0
HFD2_k127_3523960_34 PFAM FeoA family protein K04758 - - 0.000000000000002921 81.0
HFD2_k127_3523960_35 - - - - 0.00000000002443 75.0
HFD2_k127_3523960_37 - K07245 - - 0.000000002796 64.0
HFD2_k127_3523960_38 Belongs to the sulfur carrier protein TusA family - - - 0.000000005663 66.0
HFD2_k127_3523960_4 Pfam Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 541.0
HFD2_k127_3523960_40 - - - - 0.0000002529 61.0
HFD2_k127_3523960_41 Sigma-70, region 4 - - - 0.000003133 55.0
HFD2_k127_3523960_42 DNA-templated transcription, initiation K03088 - - 0.0000126 52.0
HFD2_k127_3523960_43 Transcriptional regulator, AbrB family - - - 0.00002568 49.0
HFD2_k127_3523960_45 protein conserved in bacteria - - - 0.0005638 48.0
HFD2_k127_3523960_5 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 520.0
HFD2_k127_3523960_6 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 451.0
HFD2_k127_3523960_7 response regulator K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 450.0
HFD2_k127_3523960_8 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 419.0
HFD2_k127_3523960_9 PFAM Cys Met metabolism K01739,K01760 - 2.5.1.48,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008909 419.0
HFD2_k127_3559219_0 Domain of unknown function (DUF4388) - - - 0.00000000000000000000005573 109.0
HFD2_k127_3559219_1 TIGRFAM MazG family protein K02428,K02499 - 3.6.1.66 0.00000000000000000000135 95.0
HFD2_k127_3559219_2 phosphate starvation-inducible protein PhoH K06217 - - 0.00000003876 63.0
HFD2_k127_3591907_0 PFAM response regulator receiver K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 541.0
HFD2_k127_3591907_1 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 487.0
HFD2_k127_3591907_10 - - - - 0.00000000000000308 79.0
HFD2_k127_3591907_2 Sugar (and other) transporter K08224 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 412.0
HFD2_k127_3591907_3 HAMP domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 385.0
HFD2_k127_3591907_4 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 311.0
HFD2_k127_3591907_5 Metal binding domain of Ada K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000009934 193.0
HFD2_k127_3591907_6 metallopeptidase activity K06974 - - 0.00000000000000000000000000000000000002956 149.0
HFD2_k127_3591907_7 Dodecin K09165 - - 0.0000000000000000000000002253 109.0
HFD2_k127_3591907_8 Glycine cleavage H-protein - - - 0.000000000000000000000000469 113.0
HFD2_k127_3591907_9 PFAM glycine cleavage H-protein - - - 0.00000000000000000000001833 109.0
HFD2_k127_367450_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1255.0
HFD2_k127_367450_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 552.0
HFD2_k127_367450_2 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 499.0
HFD2_k127_367450_3 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 349.0
HFD2_k127_367450_4 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000001128 198.0
HFD2_k127_367450_5 CoA-transferase family III - - - 0.000000000000000000000000000000000000358 145.0
HFD2_k127_367450_6 Tautomerase enzyme K01821 - 5.3.2.6 0.0000000000000000000000000001146 118.0
HFD2_k127_367450_7 metal cluster binding - - - 0.00000000000000000000000001974 117.0
HFD2_k127_367450_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000001146 91.0
HFD2_k127_367450_9 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000003653 58.0
HFD2_k127_3693462_0 PFAM Glu Leu Phe Val dehydrogenase K15371 - 1.4.1.2 0.0 1263.0
HFD2_k127_3693462_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.473e-298 941.0
HFD2_k127_3693462_10 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 306.0
HFD2_k127_3693462_11 transmembrane transport K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 302.0
HFD2_k127_3693462_12 regulatory protein TetR - - - 0.000000000000000000000000000000000000000000000000004116 188.0
HFD2_k127_3693462_13 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000006332 169.0
HFD2_k127_3693462_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000007814 129.0
HFD2_k127_3693462_15 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000003535 111.0
HFD2_k127_3693462_16 CGNR zinc finger - - - 0.0000000000000000000000006148 112.0
HFD2_k127_3693462_17 PFAM Cytochrome c, class I - - - 0.00000000000000000001168 93.0
HFD2_k127_3693462_18 Belongs to the universal stress protein A family - - - 0.0000000000000002687 86.0
HFD2_k127_3693462_19 Receptor family ligand binding region K01999 - - 0.000000000003344 81.0
HFD2_k127_3693462_2 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 487.0
HFD2_k127_3693462_20 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000006356 78.0
HFD2_k127_3693462_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 481.0
HFD2_k127_3693462_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 484.0
HFD2_k127_3693462_5 SMART helicase c2 K03722 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 472.0
HFD2_k127_3693462_6 DnaJ central domain K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 430.0
HFD2_k127_3693462_7 PFAM Radical SAM K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000969 353.0
HFD2_k127_3693462_8 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 332.0
HFD2_k127_3693462_9 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 316.0
HFD2_k127_3716813_0 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 479.0
HFD2_k127_3716813_1 Pkd domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006435 253.0
HFD2_k127_3716813_2 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000001086 221.0
HFD2_k127_3716813_4 - - - - 0.0000000002226 66.0
HFD2_k127_3756241_0 Receptor family ligand binding region K01999 - - 2.644e-208 655.0
HFD2_k127_3756241_1 Extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 575.0
HFD2_k127_3756241_10 amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 288.0
HFD2_k127_3756241_11 PFAM short-chain dehydrogenase reductase SDR K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000004716 238.0
HFD2_k127_3756241_12 Iron-containing alcohol dehydrogenase - - - 0.0000000000004024 83.0
HFD2_k127_3756241_2 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K14534 - 4.2.1.120,5.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 564.0
HFD2_k127_3756241_3 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 424.0
HFD2_k127_3756241_4 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483,K21726 - 1.14.13.166,1.14.13.29,1.14.14.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 394.0
HFD2_k127_3756241_5 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 373.0
HFD2_k127_3756241_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 378.0
HFD2_k127_3756241_7 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 343.0
HFD2_k127_3756241_8 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 333.0
HFD2_k127_3756241_9 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 293.0
HFD2_k127_3781193_0 PFAM Cys Met metabolism K01740 - 2.5.1.49 1.458e-216 679.0
HFD2_k127_3781193_1 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 507.0
HFD2_k127_3781193_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000002732 165.0
HFD2_k127_3781193_3 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.0000000000000000000000000000001024 129.0
HFD2_k127_3781193_4 PAS fold - - - 0.00000000272 64.0
HFD2_k127_3785651_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 475.0
HFD2_k127_3785651_1 PFAM Sodium sulphate symporter K03319,K11106 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 460.0
HFD2_k127_3785651_2 membrane protein, TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 452.0
HFD2_k127_3785651_3 Sodium:sulfate symporter transmembrane region K11106 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015297,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000002913 102.0
HFD2_k127_3785651_4 Belongs to the WrbA family K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.0000000000008017 68.0
HFD2_k127_3785651_5 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000002747 61.0
HFD2_k127_3815326_0 Glycosyltransferase family 20 K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.0 1067.0
HFD2_k127_3815326_1 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 475.0
HFD2_k127_3815326_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 462.0
HFD2_k127_3815326_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 463.0
HFD2_k127_3815326_4 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 402.0
HFD2_k127_3815326_5 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000815 394.0
HFD2_k127_3815326_6 PFAM ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 291.0
HFD2_k127_3815326_7 abc transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000001807 252.0
HFD2_k127_3815326_9 Rubrerythrin - - - 0.00003115 53.0
HFD2_k127_4065290_0 elongation factor Tu domain 2 protein K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 483.0
HFD2_k127_4065290_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 374.0
HFD2_k127_4065290_10 Transcriptional regulator, CarD family K07736 - - 0.0000000000000000000000000000000000000000000000000001033 196.0
HFD2_k127_4065290_11 TIGRFAM molybdenum cofactor synthesis domain - - - 0.0000000000000000000000000000000000000000000000000005984 190.0
HFD2_k127_4065290_12 MOSC domain - - - 0.00000000000000000000000000000000000000000000000002721 191.0
HFD2_k127_4065290_13 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000001463 135.0
HFD2_k127_4065290_14 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000004499 104.0
HFD2_k127_4065290_15 phosphorelay signal transduction system - - - 0.000000000000000000008441 101.0
HFD2_k127_4065290_16 PFAM GGDEF domain containing protein - - - 0.00000005851 65.0
HFD2_k127_4065290_17 SMART Tetratricopeptide repeat - - - 0.00000939 58.0
HFD2_k127_4065290_2 metal-dependent phosphohydrolase HD region K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 361.0
HFD2_k127_4065290_3 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 353.0
HFD2_k127_4065290_4 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 340.0
HFD2_k127_4065290_5 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 329.0
HFD2_k127_4065290_6 PFAM asparagine synthase K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 315.0
HFD2_k127_4065290_7 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001143 268.0
HFD2_k127_4065290_8 ThiF family K03148,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000003684 272.0
HFD2_k127_4065290_9 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002198 255.0
HFD2_k127_4104707_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 556.0
HFD2_k127_4104707_1 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 509.0
HFD2_k127_4104707_2 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000009653 102.0
HFD2_k127_4104707_3 Domain of unknown function (DUF4115) K15539 - - 0.000000000000000003547 97.0
HFD2_k127_4104707_4 Domain of unknown function (DUF1736) - - - 0.0000006982 56.0
HFD2_k127_4196960_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.913e-286 909.0
HFD2_k127_4196960_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 590.0
HFD2_k127_4196960_10 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000189 167.0
HFD2_k127_4196960_11 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000005524 93.0
HFD2_k127_4196960_12 Modulates RecA activity K03565 GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - 0.00000001067 63.0
HFD2_k127_4196960_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 528.0
HFD2_k127_4196960_3 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 502.0
HFD2_k127_4196960_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 394.0
HFD2_k127_4196960_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 380.0
HFD2_k127_4196960_6 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 319.0
HFD2_k127_4196960_7 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003375 283.0
HFD2_k127_4196960_8 PFAM ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005707 285.0
HFD2_k127_4196960_9 NAD dependent epimerase/dehydratase family K07535 - - 0.000000000000000000000000000000000000000000000000000000000000000000001108 250.0
HFD2_k127_4250118_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 1.664e-242 758.0
HFD2_k127_4250118_1 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.201e-221 696.0
HFD2_k127_4250118_10 PFAM Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000007658 173.0
HFD2_k127_4250118_11 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000001086 157.0
HFD2_k127_4250118_12 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000006047 146.0
HFD2_k127_4250118_13 Smr domain - - - 0.000000000000000000000000000001097 124.0
HFD2_k127_4250118_14 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000001801 136.0
HFD2_k127_4250118_15 Diguanylate cyclase - - - 0.00000000000000000000000000000569 133.0
HFD2_k127_4250118_16 membrane transporter protein K07090 - - 0.000000000000000000000000001465 117.0
HFD2_k127_4250118_17 Histidine kinase-like ATPases - - - 0.0000005415 51.0
HFD2_k127_4250118_2 elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 416.0
HFD2_k127_4250118_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 339.0
HFD2_k127_4250118_4 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 330.0
HFD2_k127_4250118_5 Dynamin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005658 323.0
HFD2_k127_4250118_6 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 319.0
HFD2_k127_4250118_7 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003068 281.0
HFD2_k127_4250118_8 NapC/NirT cytochrome c family, N-terminal region K15876 - - 0.00000000000000000000000000000000000000000000000000000000005518 222.0
HFD2_k127_4250118_9 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000007074 197.0
HFD2_k127_4368172_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1630.0
HFD2_k127_4368172_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 1.658e-307 975.0
HFD2_k127_4368172_10 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000005361 226.0
HFD2_k127_4368172_11 - - - - 0.0000000000000000000000000000000000000000000000000003572 192.0
HFD2_k127_4368172_12 transcription factor binding - - - 0.0000000000000000000000000003712 117.0
HFD2_k127_4368172_13 Histidine kinase - - - 0.000000000000000007161 99.0
HFD2_k127_4368172_2 Alpha amylase, C-terminal all-beta domain K00700 - 2.4.1.18 1.814e-279 883.0
HFD2_k127_4368172_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 490.0
HFD2_k127_4368172_4 CobB/CobQ-like glutamine amidotransferase domain K01952 GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0007275,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009555,GO:0009570,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0030554,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048229,GO:0048856,GO:0055046,GO:0097159,GO:0097367,GO:1901265,GO:1901363 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 397.0
HFD2_k127_4368172_5 ATP-binding region, ATPase domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 351.0
HFD2_k127_4368172_6 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 315.0
HFD2_k127_4368172_7 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 340.0
HFD2_k127_4368172_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 302.0
HFD2_k127_4368172_9 Histidine kinase A domain protein K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002339 287.0
HFD2_k127_4409719_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1114.0
HFD2_k127_4409719_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 625.0
HFD2_k127_4409719_10 sodium-dependent phosphate transmembrane transporter activity K03324 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000558 292.0
HFD2_k127_4409719_11 - - - - 0.00000000000000000000000001596 109.0
HFD2_k127_4409719_12 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000006103 107.0
HFD2_k127_4409719_13 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.0000000000000000000002509 112.0
HFD2_k127_4409719_14 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000008205 90.0
HFD2_k127_4409719_15 Domain of unknown function (DUF4115) K15539 - - 0.000000000008501 78.0
HFD2_k127_4409719_16 - - - - 0.000000002355 63.0
HFD2_k127_4409719_2 Domain of unknown function (DUF3552) K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 601.0
HFD2_k127_4409719_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 623.0
HFD2_k127_4409719_4 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 511.0
HFD2_k127_4409719_5 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 487.0
HFD2_k127_4409719_6 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 379.0
HFD2_k127_4409719_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 338.0
HFD2_k127_4409719_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 320.0
HFD2_k127_4409719_9 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 291.0
HFD2_k127_4439284_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 562.0
HFD2_k127_4439284_1 Cytochrome bd-type quinol oxidase subunit 1 K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 507.0
HFD2_k127_4439284_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 438.0
HFD2_k127_4439284_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 370.0
HFD2_k127_4439284_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 338.0
HFD2_k127_4439284_5 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 313.0
HFD2_k127_4439284_6 PFAM ABC transporter related K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 323.0
HFD2_k127_4439284_7 oxidase, subunit K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 289.0
HFD2_k127_4439284_8 A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002985 259.0
HFD2_k127_4439284_9 WYL domain K13573 - - 0.00000000000000000000000000000000006567 147.0
HFD2_k127_4554169_0 sigma factor activity K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 472.0
HFD2_k127_4554169_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 447.0
HFD2_k127_4554169_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001122 244.0
HFD2_k127_4554169_3 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000528 200.0
HFD2_k127_4554169_4 PFAM DGPFAETKE family protein - - - 0.0000000000000000000000000000000000000000000000001433 183.0
HFD2_k127_4554169_5 Domain of unknown function (DUF4149) - - - 0.0000000000003665 72.0
HFD2_k127_4666610_0 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 503.0
HFD2_k127_4666610_1 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 518.0
HFD2_k127_4666610_10 IMP dehydrogenase activity K04767 - - 0.00000000000000000000000000000000000000000001198 170.0
HFD2_k127_4666610_11 Nitroreductase family - - - 0.000000000000000000000000000000000004512 145.0
HFD2_k127_4666610_12 PFAM CBS domain - - - 0.00000000000000000000000000002712 132.0
HFD2_k127_4666610_13 Thioredoxin-like K02199 - - 0.00000000000000000000000000006284 122.0
HFD2_k127_4666610_14 - - - - 0.00000000000000000000000000361 120.0
HFD2_k127_4666610_15 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000000000002271 111.0
HFD2_k127_4666610_16 - - - - 0.0000000000000000001534 94.0
HFD2_k127_4666610_17 Nitrogen regulation K07712 - - 0.0000000000000002417 87.0
HFD2_k127_4666610_18 Ferredoxin - GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - 0.0000000000000006955 83.0
HFD2_k127_4666610_19 Tfp pilus assembly protein FimV - - - 0.0000000000001223 85.0
HFD2_k127_4666610_2 Beta-eliminating lyase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 441.0
HFD2_k127_4666610_21 PFAM Rhodanese domain protein - - - 0.00001218 54.0
HFD2_k127_4666610_22 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0001659 47.0
HFD2_k127_4666610_23 Helix-turn-helix domain - - - 0.0008077 46.0
HFD2_k127_4666610_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 402.0
HFD2_k127_4666610_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 306.0
HFD2_k127_4666610_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001848 287.0
HFD2_k127_4666610_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002975 258.0
HFD2_k127_4666610_7 DNA integration K14059 - - 0.00000000000000000000000000000000000000000000000000000000000001198 230.0
HFD2_k127_4666610_8 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000002863 218.0
HFD2_k127_4666610_9 assembly protein, NifU family K04488 - - 0.00000000000000000000000000000000000000000000000003956 197.0
HFD2_k127_4669830_0 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1669.0
HFD2_k127_4669830_1 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1653.0
HFD2_k127_4669830_10 PFAM Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 560.0
HFD2_k127_4669830_11 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 525.0
HFD2_k127_4669830_12 COG0277 FAD FMN-containing dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 503.0
HFD2_k127_4669830_13 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006819 497.0
HFD2_k127_4669830_14 HlyD family secretion protein K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 499.0
HFD2_k127_4669830_15 TOBE domain K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009423 376.0
HFD2_k127_4669830_16 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 357.0
HFD2_k127_4669830_17 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 351.0
HFD2_k127_4669830_18 glycerophosphodiester transmembrane transport K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 343.0
HFD2_k127_4669830_19 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000359 270.0
HFD2_k127_4669830_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 8.219e-311 964.0
HFD2_k127_4669830_20 intracellular protease K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000002173 234.0
HFD2_k127_4669830_21 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000001113 227.0
HFD2_k127_4669830_22 Yhs domain-containing protein - - - 0.00000000000000000000000000000000000000000000000005431 182.0
HFD2_k127_4669830_23 Flavin reductase like domain K00484,K16048 - 1.5.1.36 0.00000000000000000000001769 115.0
HFD2_k127_4669830_24 - - - - 0.00000000000000000002543 102.0
HFD2_k127_4669830_25 polyketide cyclase - - - 0.000000000000000000168 100.0
HFD2_k127_4669830_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 5.784e-299 925.0
HFD2_k127_4669830_4 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 7.08e-227 715.0
HFD2_k127_4669830_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11383 - 2.7.13.3 5.487e-224 710.0
HFD2_k127_4669830_6 PFAM response regulator receiver K11384 - - 1.445e-208 659.0
HFD2_k127_4669830_7 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 622.0
HFD2_k127_4669830_8 Major facilitator superfamily K08167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 610.0
HFD2_k127_4669830_9 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 563.0
HFD2_k127_47304_0 Aminoacyl-tRNA editing domain K01881 - 6.1.1.15 6.918e-222 720.0
HFD2_k127_47304_1 Tfp pilus assembly protein tip-associated adhesin K02674 - - 8.457e-207 690.0
HFD2_k127_47304_10 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000000003169 166.0
HFD2_k127_47304_11 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000001823 167.0
HFD2_k127_47304_12 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000002797 109.0
HFD2_k127_47304_13 sterol carrier protein - - - 0.000000000000000000001651 104.0
HFD2_k127_47304_14 self proteolysis - - - 0.000000000000000000003566 109.0
HFD2_k127_47304_15 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000001555 99.0
HFD2_k127_47304_16 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000002225 80.0
HFD2_k127_47304_17 - - - - 0.00000000000003018 82.0
HFD2_k127_47304_18 Prokaryotic N-terminal methylation motif K02671 - - 0.00000000001595 72.0
HFD2_k127_47304_2 CoA binding domain K01905,K22224 - 6.2.1.13 9.652e-196 635.0
HFD2_k127_47304_20 Prokaryotic N-terminal methylation motif - - - 0.00002368 54.0
HFD2_k127_47304_22 Prokaryotic N-terminal methylation motif K02671 - - 0.0003359 49.0
HFD2_k127_47304_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 450.0
HFD2_k127_47304_4 Belongs to the AlaDH PNT family K00259 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 361.0
HFD2_k127_47304_5 PFAM Silent information regulator protein Sir2 K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000576 270.0
HFD2_k127_47304_6 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000002144 228.0
HFD2_k127_47304_7 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000000000000003128 194.0
HFD2_k127_47304_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000003323 194.0
HFD2_k127_47304_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000004482 174.0
HFD2_k127_4831698_0 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 584.0
HFD2_k127_4831698_1 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 574.0
HFD2_k127_4831698_10 peroxiredoxin activity K01607 - 4.1.1.44 0.000000000000148 73.0
HFD2_k127_4831698_11 alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.00000000004846 66.0
HFD2_k127_4831698_12 Beta-lactamase superfamily domain - - - 0.0000001984 57.0
HFD2_k127_4831698_13 - - - - 0.000002317 58.0
HFD2_k127_4831698_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 570.0
HFD2_k127_4831698_3 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 529.0
HFD2_k127_4831698_4 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000001606 174.0
HFD2_k127_4831698_5 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000001008 154.0
HFD2_k127_4831698_6 Glycogen debranching enzyme - - - 0.000000000000000000000000000000000009156 139.0
HFD2_k127_4831698_7 - - - - 0.000000000000000000000000000002068 126.0
HFD2_k127_4831698_8 AraC-like ligand binding domain - - - 0.0000000000000000000000001657 116.0
HFD2_k127_4831698_9 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.000000000000001074 80.0
HFD2_k127_4903602_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 327.0
HFD2_k127_4903602_1 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 330.0
HFD2_k127_4903602_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 299.0
HFD2_k127_4903602_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000001924 204.0
HFD2_k127_4903602_4 Cytochrome c - - - 0.00000000000000000000000000000000000000000292 172.0
HFD2_k127_4903602_5 AraC-like ligand binding domain - - - 0.00000000000000000000000002022 112.0
HFD2_k127_4903602_6 2-Nitropropane dioxygenase - - - 0.0000000000000007524 83.0
HFD2_k127_5148830_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1194.0
HFD2_k127_5148830_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.216e-259 816.0
HFD2_k127_5148830_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 8.048e-236 741.0
HFD2_k127_5148830_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 385.0
HFD2_k127_5148830_4 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 353.0
HFD2_k127_5148830_5 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000000001114 220.0
HFD2_k127_5148830_6 CBS domain K04767 - - 0.0000000000000000000000003974 116.0
HFD2_k127_5148830_7 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000001839 116.0
HFD2_k127_5148830_8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000007449 86.0
HFD2_k127_5148830_9 - - - - 0.000000000000000003075 87.0
HFD2_k127_5215704_0 Fumarate reductase flavoprotein C-term K00239,K00244,K00278 GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 3.727e-259 810.0
HFD2_k127_5215704_1 Belongs to the peptidase S16 family - - - 3.75e-228 732.0
HFD2_k127_5215704_10 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001316 265.0
HFD2_k127_5215704_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000001349 251.0
HFD2_k127_5215704_12 Pfam Enoyl-CoA hydratase isomerase K13816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001697 254.0
HFD2_k127_5215704_13 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003839 241.0
HFD2_k127_5215704_14 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000009218 214.0
HFD2_k127_5215704_15 ACT domain protein K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.00000000000000000000000000000000000000000008833 163.0
HFD2_k127_5215704_16 Cache_2 - - - 0.000000000000000000000000000000000000001462 153.0
HFD2_k127_5215704_17 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00247 - - 0.0000000000000000000000000001726 117.0
HFD2_k127_5215704_18 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00246 - - 0.000000000000000000000000001779 117.0
HFD2_k127_5215704_19 response regulator, receiver K07814 - - 0.0000000489 56.0
HFD2_k127_5215704_2 PFAM Xanthine uracil vitamin C permease K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 600.0
HFD2_k127_5215704_20 Cold-shock protein K03704 - - 0.00002997 47.0
HFD2_k127_5215704_3 Histidine kinase K10715,K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 595.0
HFD2_k127_5215704_4 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 489.0
HFD2_k127_5215704_5 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 451.0
HFD2_k127_5215704_6 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 396.0
HFD2_k127_5215704_7 Succinate dehydrogenase fumarate reductase K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 348.0
HFD2_k127_5215704_8 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 358.0
HFD2_k127_5215704_9 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 283.0
HFD2_k127_5280453_0 nitric oxide reductase activity K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 577.0
HFD2_k127_5280453_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 524.0
HFD2_k127_5280453_10 Transcriptional regulatory protein, C terminal K07658 - - 0.000000000000000000000000000000000000000000000000000000000000000000001491 245.0
HFD2_k127_5280453_11 Protein of unknown function DUF47 K02039,K07220 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000005658 240.0
HFD2_k127_5280453_12 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000002104 213.0
HFD2_k127_5280453_13 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000007343 199.0
HFD2_k127_5280453_14 MGS-like domain K01734 - 4.2.3.3 0.0000000000000000000000000000000000000000002051 163.0
HFD2_k127_5280453_15 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000000000000000000000255 171.0
HFD2_k127_5280453_16 regulation of single-species biofilm formation K02342,K03763,K13573 - 2.7.7.7 0.000000000000000000000000000001516 126.0
HFD2_k127_5280453_17 Rubredoxin - - - 0.00000000000000000000000126 103.0
HFD2_k127_5280453_18 Rubrerythrin - - - 0.000000000007118 67.0
HFD2_k127_5280453_2 Chromate K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 483.0
HFD2_k127_5280453_3 GAF domain K02584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 452.0
HFD2_k127_5280453_4 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 422.0
HFD2_k127_5280453_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 334.0
HFD2_k127_5280453_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 332.0
HFD2_k127_5280453_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 316.0
HFD2_k127_5280453_8 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 327.0
HFD2_k127_5280453_9 TIGRFAM phosphate ABC transporter K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002192 295.0
HFD2_k127_5291823_0 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 520.0
HFD2_k127_5291823_1 MmgE PrpD family protein K01720 - 4.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 499.0
HFD2_k127_5299205_0 L-glutamate biosynthetic process K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2002.0
HFD2_k127_5299205_1 Peptidase family M1 domain - - - 1.734e-216 692.0
HFD2_k127_5299205_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 527.0
HFD2_k127_5299205_3 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 501.0
HFD2_k127_5299205_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 500.0
HFD2_k127_5299205_5 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 376.0
HFD2_k127_5299205_6 regulatory protein LysR K02019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 324.0
HFD2_k127_5299205_7 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 292.0
HFD2_k127_5299205_8 ABC transporter K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000001255 228.0
HFD2_k127_5299205_9 protocatechuate 3,4-dioxygenase activity K03381 - 1.13.11.1 0.000001894 53.0
HFD2_k127_5360755_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 442.0
HFD2_k127_5360755_1 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 426.0
HFD2_k127_5360755_10 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000006149 206.0
HFD2_k127_5360755_11 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000000003661 120.0
HFD2_k127_5360755_12 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000003435 101.0
HFD2_k127_5360755_13 heat shock protein binding - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000004106 87.0
HFD2_k127_5360755_14 - - - - 0.00000000000000519 84.0
HFD2_k127_5360755_16 - - - - 0.00000000005904 68.0
HFD2_k127_5360755_17 Peptidase family M48 - - - 0.0000000002887 74.0
HFD2_k127_5360755_2 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 349.0
HFD2_k127_5360755_3 Domain of unknown function (DUF4070) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 323.0
HFD2_k127_5360755_4 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007762 311.0
HFD2_k127_5360755_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 304.0
HFD2_k127_5360755_6 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001961 289.0
HFD2_k127_5360755_7 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004504 276.0
HFD2_k127_5360755_8 PFAM ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000001079 224.0
HFD2_k127_5360755_9 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000001386 233.0
HFD2_k127_5403644_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.338e-195 621.0
HFD2_k127_5403644_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008301 611.0
HFD2_k127_5403644_10 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 333.0
HFD2_k127_5403644_11 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009925 318.0
HFD2_k127_5403644_12 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 323.0
HFD2_k127_5403644_13 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 317.0
HFD2_k127_5403644_14 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 308.0
HFD2_k127_5403644_15 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 291.0
HFD2_k127_5403644_16 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 285.0
HFD2_k127_5403644_17 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000003743 262.0
HFD2_k127_5403644_18 PFAM Sulphate transporter K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004719 257.0
HFD2_k127_5403644_19 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.00000000000000000000000000000000000000000000007223 189.0
HFD2_k127_5403644_2 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 535.0
HFD2_k127_5403644_20 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000001485 181.0
HFD2_k127_5403644_21 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000001156 149.0
HFD2_k127_5403644_22 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000001035 128.0
HFD2_k127_5403644_23 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00652,K01935 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 0.00000000000000000000000000008286 133.0
HFD2_k127_5403644_24 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000000001167 96.0
HFD2_k127_5403644_25 Cytochrome c - - - 0.00000000000002467 85.0
HFD2_k127_5403644_26 CAAX protease self-immunity K07052 - - 0.000001111 59.0
HFD2_k127_5403644_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 492.0
HFD2_k127_5403644_4 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005564 466.0
HFD2_k127_5403644_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 438.0
HFD2_k127_5403644_6 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 419.0
HFD2_k127_5403644_7 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 401.0
HFD2_k127_5403644_8 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 368.0
HFD2_k127_5403644_9 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005657 344.0
HFD2_k127_5441465_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.915e-204 665.0
HFD2_k127_5441465_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 401.0
HFD2_k127_5441465_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000002569 216.0
HFD2_k127_5441465_11 phosphinothricin N-acetyltransferase activity - - - 0.0000000000000000000000000000000000000000002815 168.0
HFD2_k127_5441465_12 Domain of unknown function (DUF4442) - - - 0.0000000007263 66.0
HFD2_k127_5441465_13 Domain of unknown function (DUF1858) - - - 0.000002458 54.0
HFD2_k127_5441465_2 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 373.0
HFD2_k127_5441465_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 363.0
HFD2_k127_5441465_4 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007273 303.0
HFD2_k127_5441465_5 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 325.0
HFD2_k127_5441465_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 297.0
HFD2_k127_5441465_7 8 heme-binding sites - - - 0.0000000000000000000000000000000000000000000000000000000000000000002666 237.0
HFD2_k127_5441465_8 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000001271 211.0
HFD2_k127_5441465_9 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000002183 204.0
HFD2_k127_550309_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 445.0
HFD2_k127_550309_1 HlyD family secretion protein K07798,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 358.0
HFD2_k127_550309_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002545 271.0
HFD2_k127_550309_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000001267 237.0
HFD2_k127_550309_4 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000997 219.0
HFD2_k127_550309_5 Predicted membrane protein (DUF2318) - - - 0.000000000000000000000000000000001216 134.0
HFD2_k127_5523094_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1182.0
HFD2_k127_5523094_1 tRNA nucleotidyltransferase poly(A) polymerase K00974 - 2.7.7.72 5.613e-265 842.0
HFD2_k127_5523094_10 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 421.0
HFD2_k127_5523094_11 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 394.0
HFD2_k127_5523094_12 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 368.0
HFD2_k127_5523094_13 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 291.0
HFD2_k127_5523094_14 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 297.0
HFD2_k127_5523094_15 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 289.0
HFD2_k127_5523094_16 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001638 300.0
HFD2_k127_5523094_17 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 284.0
HFD2_k127_5523094_18 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001639 288.0
HFD2_k127_5523094_19 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000008491 224.0
HFD2_k127_5523094_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 4.101e-225 725.0
HFD2_k127_5523094_20 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000001542 220.0
HFD2_k127_5523094_21 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000003002 214.0
HFD2_k127_5523094_22 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000001826 222.0
HFD2_k127_5523094_23 Cytidylate kinase K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000002076 214.0
HFD2_k127_5523094_24 Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000853 179.0
HFD2_k127_5523094_25 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000327 182.0
HFD2_k127_5523094_26 bacterial (prokaryotic) histone like domain K05788 - - 0.0000000000000000000000000000003384 125.0
HFD2_k127_5523094_27 TIGRFAM phosphodiesterase, MJ0936 family K07095 - - 0.00000000000000000000000002747 126.0
HFD2_k127_5523094_28 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000004549 63.0
HFD2_k127_5523094_29 - - - - 0.000000007438 57.0
HFD2_k127_5523094_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 625.0
HFD2_k127_5523094_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 578.0
HFD2_k127_5523094_5 Major Facilitator Superfamily K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 510.0
HFD2_k127_5523094_6 2Fe-2S iron-sulfur cluster binding domain K00240,K00245 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009813 434.0
HFD2_k127_5523094_7 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 427.0
HFD2_k127_5523094_8 amino acid-binding ACT domain protein K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 434.0
HFD2_k127_5523094_9 TIGRFAM tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 413.0
HFD2_k127_5555753_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 596.0
HFD2_k127_5555753_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 455.0
HFD2_k127_5555753_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009337 450.0
HFD2_k127_5555753_3 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 375.0
HFD2_k127_5555753_4 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000000000000007177 178.0
HFD2_k127_5555753_5 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000000003394 156.0
HFD2_k127_561474_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 581.0
HFD2_k127_561474_1 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004216 283.0
HFD2_k127_561474_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000001686 205.0
HFD2_k127_5721896_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009978 484.0
HFD2_k127_5721896_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007543 393.0
HFD2_k127_5721896_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 359.0
HFD2_k127_5721896_3 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 308.0
HFD2_k127_5721896_4 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002835 271.0
HFD2_k127_5721896_5 Domain of unknown function (DUF1330) - - - 0.000000000000000000000000000000000000000000000002798 174.0
HFD2_k127_5721896_6 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000001156 170.0
HFD2_k127_5721896_7 - - - - 0.00000000000000000000000000000000003095 141.0
HFD2_k127_5800191_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000074 531.0
HFD2_k127_5800191_1 Putative methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 509.0
HFD2_k127_5800191_2 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 480.0
HFD2_k127_5800191_3 PFAM FeoA family protein K04758 - - 0.00000000000000000000000000000002769 127.0
HFD2_k127_5800191_4 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.000000000000000000000000000004986 123.0
HFD2_k127_5800191_6 PFAM FeoA family protein K04758 - - 0.00000000000000003384 85.0
HFD2_k127_5800191_8 Glycine cleavage H-protein - - - 0.00001506 47.0
HFD2_k127_59122_0 Putative citrate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 467.0
HFD2_k127_59122_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 365.0
HFD2_k127_59122_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 317.0
HFD2_k127_59122_3 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 290.0
HFD2_k127_59122_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001366 289.0
HFD2_k127_59122_5 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007462 273.0
HFD2_k127_59122_6 SURF4 family K15977 - - 0.0000000000000000000000000004501 117.0
HFD2_k127_59122_7 Universal stress protein family - - - 0.0000002954 61.0
HFD2_k127_59122_8 transcription activator, effector binding - - - 0.00004589 53.0
HFD2_k127_5968486_0 Heat shock 70 kDa protein K04043 - - 7.979e-282 878.0
HFD2_k127_5968486_1 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 505.0
HFD2_k127_5968486_2 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 372.0
HFD2_k127_5968486_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000002377 247.0
HFD2_k127_5968486_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000001759 194.0
HFD2_k127_5968486_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000001169 159.0
HFD2_k127_5968486_6 Histidine Phosphotransfer domain - - - 0.00000009795 59.0
HFD2_k127_5968486_7 Domain of unknown function (DUF1844) - - - 0.000003484 53.0
HFD2_k127_5980331_0 Bacterial membrane protein, YfhO - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 537.0
HFD2_k127_5980331_1 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006854 486.0
HFD2_k127_5980331_10 Type III secretion system lipoprotein chaperone (YscW) K09914 - - 0.0000000000000000009147 94.0
HFD2_k127_5980331_11 Ubiquinone biosynthesis O-methyltransferase - - - 0.0000000000273 76.0
HFD2_k127_5980331_12 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000004804 70.0
HFD2_k127_5980331_13 May be involved in cell division K05803 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0030674,GO:0044464,GO:0051301,GO:0060090,GO:0071944 - 0.000003565 60.0
HFD2_k127_5980331_14 peptidyl-prolyl cis-trans isomerase activity K03769,K03771 - 5.2.1.8 0.000007352 58.0
HFD2_k127_5980331_15 peptidyl-prolyl isomerase K03769 - 5.2.1.8 0.0002144 53.0
HFD2_k127_5980331_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000532 445.0
HFD2_k127_5980331_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 449.0
HFD2_k127_5980331_4 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000005971 253.0
HFD2_k127_5980331_5 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000001443 231.0
HFD2_k127_5980331_6 peroxiredoxin activity - - - 0.000000000000000000000000000000000000583 153.0
HFD2_k127_5980331_7 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000001634 127.0
HFD2_k127_5980331_8 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000004853 132.0
HFD2_k127_5980331_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000001386 106.0
HFD2_k127_6002734_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1337.0
HFD2_k127_6002734_1 Pfam SNARE associated Golgi protein - - - 1.845e-244 774.0
HFD2_k127_6002734_10 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002603 269.0
HFD2_k127_6002734_11 HAD-superfamily hydrolase subfamily IA, variant 3 K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000573 246.0
HFD2_k127_6002734_12 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000007544 248.0
HFD2_k127_6002734_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000002302 238.0
HFD2_k127_6002734_14 protein possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000000000000004791 175.0
HFD2_k127_6002734_15 Cupin domain - - - 0.0000000000000000000000000000000000000001905 155.0
HFD2_k127_6002734_16 Nucleoside recognition - - - 0.0000000000000000000000000004164 121.0
HFD2_k127_6002734_17 Nucleoside recognition - - - 0.0000000000000000000000324 113.0
HFD2_k127_6002734_18 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000001888 73.0
HFD2_k127_6002734_19 - - - - 0.000000000004518 76.0
HFD2_k127_6002734_2 O-methyltransferase activity - - - 1.292e-235 747.0
HFD2_k127_6002734_21 Protein of unknown function (DUF2889) - - - 0.0009893 51.0
HFD2_k127_6002734_3 Multicopper oxidase K06324 - 1.16.3.3 9.735e-231 736.0
HFD2_k127_6002734_4 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 624.0
HFD2_k127_6002734_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 529.0
HFD2_k127_6002734_6 Single cache domain 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 364.0
HFD2_k127_6002734_7 peptidase M29 K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 334.0
HFD2_k127_6002734_8 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 331.0
HFD2_k127_6002734_9 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000553 286.0
HFD2_k127_6140940_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1124.0
HFD2_k127_6140940_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.486e-253 790.0
HFD2_k127_6140940_10 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 501.0
HFD2_k127_6140940_11 Belongs to the EPSP synthase family. MurA subfamily K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009122 474.0
HFD2_k127_6140940_12 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 453.0
HFD2_k127_6140940_13 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 427.0
HFD2_k127_6140940_14 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 430.0
HFD2_k127_6140940_15 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 431.0
HFD2_k127_6140940_16 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 411.0
HFD2_k127_6140940_17 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 395.0
HFD2_k127_6140940_18 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 375.0
HFD2_k127_6140940_19 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 370.0
HFD2_k127_6140940_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.296e-238 752.0
HFD2_k127_6140940_20 Histidinol dehydrogenase K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008868 369.0
HFD2_k127_6140940_21 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 371.0
HFD2_k127_6140940_22 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 356.0
HFD2_k127_6140940_23 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009501 366.0
HFD2_k127_6140940_24 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 353.0
HFD2_k127_6140940_25 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 340.0
HFD2_k127_6140940_26 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 343.0
HFD2_k127_6140940_27 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 334.0
HFD2_k127_6140940_28 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 333.0
HFD2_k127_6140940_29 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 335.0
HFD2_k127_6140940_3 thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 3.567e-230 751.0
HFD2_k127_6140940_30 PFAM ABC transporter related K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 308.0
HFD2_k127_6140940_31 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 301.0
HFD2_k127_6140940_32 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 286.0
HFD2_k127_6140940_33 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 294.0
HFD2_k127_6140940_34 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005437 293.0
HFD2_k127_6140940_35 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000125 284.0
HFD2_k127_6140940_36 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000462 287.0
HFD2_k127_6140940_37 S4 RNA-binding domain K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001139 282.0
HFD2_k127_6140940_38 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005074 263.0
HFD2_k127_6140940_39 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000003233 259.0
HFD2_k127_6140940_4 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 9.927e-209 655.0
HFD2_k127_6140940_40 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000001393 254.0
HFD2_k127_6140940_41 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000001288 243.0
HFD2_k127_6140940_42 Protein of unknown function (DUF1385) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001457 252.0
HFD2_k127_6140940_43 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000001148 253.0
HFD2_k127_6140940_44 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000002616 239.0
HFD2_k127_6140940_45 TIGRFAM acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000001978 227.0
HFD2_k127_6140940_46 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000002808 240.0
HFD2_k127_6140940_47 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000001827 237.0
HFD2_k127_6140940_48 Ribosome recycling factor K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000001964 206.0
HFD2_k127_6140940_49 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000008533 202.0
HFD2_k127_6140940_5 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 609.0
HFD2_k127_6140940_50 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000003332 202.0
HFD2_k127_6140940_51 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000002214 201.0
HFD2_k127_6140940_52 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000003754 197.0
HFD2_k127_6140940_53 PFAM permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000000001545 193.0
HFD2_k127_6140940_54 PFAM permease YjgP YjgQ family protein K11720 - - 0.0000000000000000000000000000000000000000000000618 192.0
HFD2_k127_6140940_55 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000001973 179.0
HFD2_k127_6140940_56 Ribosomal protein K02871 GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0031974,GO:0032543,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0097159,GO:0098798,GO:0140053,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000005671 173.0
HFD2_k127_6140940_57 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000000000000001287 159.0
HFD2_k127_6140940_58 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000000002727 162.0
HFD2_k127_6140940_59 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000003005 162.0
HFD2_k127_6140940_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 610.0
HFD2_k127_6140940_60 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000004991 156.0
HFD2_k127_6140940_61 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000003639 144.0
HFD2_k127_6140940_62 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000001491 147.0
HFD2_k127_6140940_63 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000001007 143.0
HFD2_k127_6140940_64 Yqey-like protein K09117 - - 0.000000000000000000000000000000001739 134.0
HFD2_k127_6140940_65 NIF3 (NGG1p interacting factor 3) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000009472 135.0
HFD2_k127_6140940_66 PFAM PTS system mannose fructose sorbose family IID component K02796 - - 0.0000000000000000000000000000009512 137.0
HFD2_k127_6140940_67 PFAM PTS system fructose subfamily IIA component K02793 - 2.7.1.191 0.000000000000000000000000000001979 138.0
HFD2_k127_6140940_68 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000002166 124.0
HFD2_k127_6140940_69 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.0000000000000000000000000002366 124.0
HFD2_k127_6140940_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008208 618.0
HFD2_k127_6140940_70 PFAM PTS system sorbose subfamily IIB component K02794 - 2.7.1.191 0.000000000000000000000000001058 125.0
HFD2_k127_6140940_71 Binds the 23S rRNA K02909 - - 0.0000000000000000000000003721 106.0
HFD2_k127_6140940_72 PTS system sorbose-specific iic component K02795 - - 0.0000000000000000000000008554 117.0
HFD2_k127_6140940_73 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000005035 103.0
HFD2_k127_6140940_74 YtxH-like protein - - - 0.00000000000000000000004905 107.0
HFD2_k127_6140940_75 - - - - 0.00000000000000000000007767 100.0
HFD2_k127_6140940_76 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000001029 108.0
HFD2_k127_6140940_77 dihydromethanopterin reductase activity - - - 0.00000000000000000002389 92.0
HFD2_k127_6140940_78 EAL domain - - - 0.00000000000000000004959 102.0
HFD2_k127_6140940_79 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.1,2.4.2.2 0.0000000000000000002788 90.0
HFD2_k127_6140940_8 PEP-utilising enzyme, N-terminal K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 570.0
HFD2_k127_6140940_80 - - - - 0.000000000748 62.0
HFD2_k127_6140940_81 Protein of unknown function (DUF465) K09794 - - 0.00000001502 58.0
HFD2_k127_6140940_9 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 519.0
HFD2_k127_6151497_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K00344,K00966,K01840,K03431,K15778,K16881 - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 3.28e-284 896.0
HFD2_k127_6151497_1 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 2.015e-238 765.0
HFD2_k127_6151497_10 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 405.0
HFD2_k127_6151497_11 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 390.0
HFD2_k127_6151497_12 PFAM Band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 369.0
HFD2_k127_6151497_13 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 371.0
HFD2_k127_6151497_14 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 355.0
HFD2_k127_6151497_15 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 329.0
HFD2_k127_6151497_16 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 307.0
HFD2_k127_6151497_17 SMART PUA domain containing protein K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 301.0
HFD2_k127_6151497_18 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000674 302.0
HFD2_k127_6151497_19 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000151 280.0
HFD2_k127_6151497_2 Translation-initiation factor 2 K02519 - - 5.131e-236 755.0
HFD2_k127_6151497_20 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000001214 258.0
HFD2_k127_6151497_21 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000003422 224.0
HFD2_k127_6151497_22 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000003962 228.0
HFD2_k127_6151497_23 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000000004142 199.0
HFD2_k127_6151497_24 dUTPase K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000001439 188.0
HFD2_k127_6151497_25 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000003008 203.0
HFD2_k127_6151497_26 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000002788 177.0
HFD2_k127_6151497_27 PFAM Stage II sporulation K06381 - - 0.00000000000000000000000000000000000000000005313 183.0
HFD2_k127_6151497_28 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000007287 167.0
HFD2_k127_6151497_29 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000000000428 133.0
HFD2_k127_6151497_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 598.0
HFD2_k127_6151497_30 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000009968 129.0
HFD2_k127_6151497_31 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000000005719 114.0
HFD2_k127_6151497_32 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000001697 117.0
HFD2_k127_6151497_33 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000002946 106.0
HFD2_k127_6151497_34 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000001499 92.0
HFD2_k127_6151497_35 Protein of unknown function (DUF503) K09764 - - 0.0000000000003074 74.0
HFD2_k127_6151497_36 Protein of unknown function (DUF448) K07742 - - 0.0000003541 63.0
HFD2_k127_6151497_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 517.0
HFD2_k127_6151497_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 493.0
HFD2_k127_6151497_6 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 443.0
HFD2_k127_6151497_7 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 427.0
HFD2_k127_6151497_8 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 410.0
HFD2_k127_6151497_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 398.0
HFD2_k127_6163903_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 2.063e-243 758.0
HFD2_k127_6163903_1 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000005501 210.0
HFD2_k127_6163903_2 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000003813 197.0
HFD2_k127_6163903_3 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.000000000000000000000000000000000000000000003521 183.0
HFD2_k127_6163903_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000001716 160.0
HFD2_k127_6163903_5 TPM domain K06872 - - 0.00000000000000000000000000000000001151 145.0
HFD2_k127_6163903_6 nucleotidyltransferase activity - - - 0.0000000000000000000000083 110.0
HFD2_k127_6163903_7 RNA-binding protein containing a PIN domain - - - 0.0000000001656 70.0
HFD2_k127_6163903_8 gluconolactonase activity K08884 - 2.7.11.1 0.0000008572 61.0
HFD2_k127_6166878_0 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 511.0
HFD2_k127_6166878_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 460.0
HFD2_k127_6166878_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 397.0
HFD2_k127_6166878_3 HlyD family secretion protein K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000001717 231.0
HFD2_k127_6166878_4 UPF0126 domain - - - 0.00000000001665 73.0
HFD2_k127_6182239_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1072.0
HFD2_k127_6182239_1 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 2.426e-297 919.0
HFD2_k127_6182239_10 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 393.0
HFD2_k127_6182239_11 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 345.0
HFD2_k127_6182239_12 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 351.0
HFD2_k127_6182239_13 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 330.0
HFD2_k127_6182239_14 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 319.0
HFD2_k127_6182239_15 Metal-dependent phosphohydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003272 325.0
HFD2_k127_6182239_16 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002952 280.0
HFD2_k127_6182239_17 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001012 271.0
HFD2_k127_6182239_18 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000136 267.0
HFD2_k127_6182239_19 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009699 251.0
HFD2_k127_6182239_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006079 597.0
HFD2_k127_6182239_20 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000005363 236.0
HFD2_k127_6182239_21 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000003029 211.0
HFD2_k127_6182239_22 ATP cone domain K07738 - - 0.000000000000000000000000000000000000000000000000000000002425 206.0
HFD2_k127_6182239_23 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000006777 197.0
HFD2_k127_6182239_24 COG0698 Ribose 5-phosphate isomerase RpiB K01808 - 5.3.1.6 0.0000000000000000000000000000000000000004503 157.0
HFD2_k127_6182239_25 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000004136 123.0
HFD2_k127_6182239_26 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000006964 111.0
HFD2_k127_6182239_27 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000007601 102.0
HFD2_k127_6182239_28 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000004336 96.0
HFD2_k127_6182239_29 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000001192 74.0
HFD2_k127_6182239_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 580.0
HFD2_k127_6182239_30 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000007038 72.0
HFD2_k127_6182239_31 Phage integrase family K07358 - - 0.000000000004838 70.0
HFD2_k127_6182239_32 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.00000002864 66.0
HFD2_k127_6182239_34 PFAM Tetratricopeptide repeat - - - 0.0001948 54.0
HFD2_k127_6182239_35 PFAM Type II secretion system protein E K02652 - - 0.000286 52.0
HFD2_k127_6182239_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 575.0
HFD2_k127_6182239_5 PFAM Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 524.0
HFD2_k127_6182239_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 513.0
HFD2_k127_6182239_7 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 466.0
HFD2_k127_6182239_8 PCRF K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 399.0
HFD2_k127_6182239_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 395.0
HFD2_k127_6194803_0 FtsX-like permease family K02004 - - 1.824e-272 861.0
HFD2_k127_6194803_1 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 347.0
HFD2_k127_6194803_2 Cache_2 - - - 0.0000000000000000000000000000000000000000006072 169.0
HFD2_k127_6194803_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000008617 57.0
HFD2_k127_6210579_0 Glycosyl hydrolases family 15 - - - 1.121e-232 739.0
HFD2_k127_6210579_1 Sugar (and other) transporter K03446 - - 3.283e-200 637.0
HFD2_k127_6210579_10 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003151 295.0
HFD2_k127_6210579_11 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006301 289.0
HFD2_k127_6210579_12 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004958 267.0
HFD2_k127_6210579_13 Paraquat-inducible protein B - - - 0.0000000000000000000000000000000000000000000000000000000000000000001722 245.0
HFD2_k127_6210579_14 lysyl-tRNA synthetase K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000007115 240.0
HFD2_k127_6210579_15 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000001604 227.0
HFD2_k127_6210579_16 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000002236 213.0
HFD2_k127_6210579_17 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000001681 194.0
HFD2_k127_6210579_18 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000005686 198.0
HFD2_k127_6210579_19 Low affinity iron permease - - - 0.000000000000000000000000000000000000000000001158 169.0
HFD2_k127_6210579_2 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 599.0
HFD2_k127_6210579_20 paraquat-inducible protein A K03808 - - 0.00000000000000000000000000000000000000000001854 168.0
HFD2_k127_6210579_21 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000001939 176.0
HFD2_k127_6210579_22 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.00000000000000000000000000000000000000004715 158.0
HFD2_k127_6210579_23 GYD domain - - - 0.0000000000000000000000000000000000002067 144.0
HFD2_k127_6210579_24 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.00000000000000000000000000000001502 137.0
HFD2_k127_6210579_25 TIGRFAM cytochrome C family protein - - - 0.000000000000000000000000000004142 132.0
HFD2_k127_6210579_26 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000002174 121.0
HFD2_k127_6210579_27 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000001654 120.0
HFD2_k127_6210579_28 Protein of unknown function (DUF2628) - - - 0.00000000000000001243 90.0
HFD2_k127_6210579_29 enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000001209 94.0
HFD2_k127_6210579_3 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 579.0
HFD2_k127_6210579_30 - - - - 0.00000000000001589 76.0
HFD2_k127_6210579_31 Thioesterase superfamily K02614 - - 0.00000000003892 69.0
HFD2_k127_6210579_32 Class III cytochrome C family - - - 0.0000005674 56.0
HFD2_k127_6210579_33 CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.000002466 57.0
HFD2_k127_6210579_34 Putative zinc-finger - - - 0.0001853 53.0
HFD2_k127_6210579_35 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0003133 43.0
HFD2_k127_6210579_4 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 522.0
HFD2_k127_6210579_5 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 435.0
HFD2_k127_6210579_6 helix-turn-helix- domain containing protein, AraC type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 411.0
HFD2_k127_6210579_7 PFAM LOR SDH bifunctional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 412.0
HFD2_k127_6210579_8 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 394.0
HFD2_k127_6210579_9 HlyD membrane-fusion protein of T1SS K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 304.0
HFD2_k127_6216841_0 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 3.691e-268 850.0
HFD2_k127_6216841_1 alpha beta alpha domain I K01835 - 5.4.2.2 1.736e-254 802.0
HFD2_k127_6216841_10 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000007342 234.0
HFD2_k127_6216841_11 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000001101 246.0
HFD2_k127_6216841_12 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000004738 218.0
HFD2_k127_6216841_13 PFAM OmpA MotB domain protein - - - 0.000000000000000000000000000000000000000002611 162.0
HFD2_k127_6216841_14 COG494 NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair General function prediction only K01515 - 3.6.1.13 0.000000000000000000000000000000000000007806 152.0
HFD2_k127_6216841_15 Thiamine-binding protein - - - 0.00000000000000000000000000000000000222 139.0
HFD2_k127_6216841_16 - - - - 0.0000000000000000000000000000000008945 137.0
HFD2_k127_6216841_17 Membrane - - - 0.00000000000000000000000000000005099 130.0
HFD2_k127_6216841_18 PFAM FecR protein - - - 0.000000000000000000000000000005215 124.0
HFD2_k127_6216841_19 - - - - 0.000000000000007521 79.0
HFD2_k127_6216841_2 Chase2 domain K01768,K07814 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 509.0
HFD2_k127_6216841_20 - - - - 0.00000000000002394 81.0
HFD2_k127_6216841_21 - - - - 0.0000000000001107 79.0
HFD2_k127_6216841_22 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000002282 66.0
HFD2_k127_6216841_23 transferase activity, transferring acyl groups other than amino-acyl groups K03685 - 3.1.26.3 0.0000002191 60.0
HFD2_k127_6216841_24 Tetratricopeptide repeat - - - 0.000002638 59.0
HFD2_k127_6216841_3 PHP domain protein K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 471.0
HFD2_k127_6216841_4 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 325.0
HFD2_k127_6216841_5 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 308.0
HFD2_k127_6216841_6 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 287.0
HFD2_k127_6216841_7 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000001174 263.0
HFD2_k127_6216841_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000003215 264.0
HFD2_k127_6216841_9 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000007181 267.0
HFD2_k127_6259307_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298 - 1.10.3.10,1.9.3.1 2.929e-214 678.0
HFD2_k127_6259307_1 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 520.0
HFD2_k127_6259307_10 oxidase, subunit IV K02277 - 1.9.3.1 0.000000000000000000791 89.0
HFD2_k127_6259307_2 GTP cyclohydrolase I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 294.0
HFD2_k127_6259307_3 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009218 274.0
HFD2_k127_6259307_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002486 263.0
HFD2_k127_6259307_5 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000001094 209.0
HFD2_k127_6259307_6 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000005637 202.0
HFD2_k127_6259307_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000005403 177.0
HFD2_k127_6259307_8 Cytochrome oxidase assembly protein K02259 - - 0.00000000000000000000000003326 121.0
HFD2_k127_6259307_9 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000001102 105.0
HFD2_k127_6333709_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 1.611e-292 922.0
HFD2_k127_6333709_1 Conserved carboxylase domain K01958 - 6.4.1.1 4.844e-228 734.0
HFD2_k127_6333709_10 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 391.0
HFD2_k127_6333709_11 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 391.0
HFD2_k127_6333709_12 PFAM ABC transporter transmembrane region K06147,K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 390.0
HFD2_k127_6333709_13 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 373.0
HFD2_k127_6333709_14 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 343.0
HFD2_k127_6333709_15 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 305.0
HFD2_k127_6333709_16 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006459 280.0
HFD2_k127_6333709_17 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009544 275.0
HFD2_k127_6333709_18 Bacterial membrane protein, YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002425 280.0
HFD2_k127_6333709_19 TIGRFAM methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000111 228.0
HFD2_k127_6333709_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 572.0
HFD2_k127_6333709_20 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000002243 203.0
HFD2_k127_6333709_21 Including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000005997 148.0
HFD2_k127_6333709_22 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000005881 143.0
HFD2_k127_6333709_23 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000004037 119.0
HFD2_k127_6333709_25 - - - - 0.00001872 47.0
HFD2_k127_6333709_3 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 541.0
HFD2_k127_6333709_4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008763 528.0
HFD2_k127_6333709_5 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 520.0
HFD2_k127_6333709_6 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 500.0
HFD2_k127_6333709_7 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 484.0
HFD2_k127_6333709_8 ABC transporter transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 501.0
HFD2_k127_6333709_9 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 446.0
HFD2_k127_6343203_0 Aminotransferase class I and II K10206,K14261 GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 574.0
HFD2_k127_6343203_1 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 526.0
HFD2_k127_6343203_10 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 372.0
HFD2_k127_6343203_11 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 308.0
HFD2_k127_6343203_12 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000009841 199.0
HFD2_k127_6343203_13 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000001191 196.0
HFD2_k127_6343203_14 PFAM Pyruvate ketoisovalerate oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000000000001926 201.0
HFD2_k127_6343203_15 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000002355 169.0
HFD2_k127_6343203_16 Transcription regulator MerR DNA binding K21902 - - 0.000000000000000000000000000000000000001318 151.0
HFD2_k127_6343203_17 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.000000000000000000000000000001605 124.0
HFD2_k127_6343203_18 Plasmid stabilization system - - - 0.000000000000000000003168 96.0
HFD2_k127_6343203_19 4 iron, 4 sulfur cluster binding K00176 - 1.2.7.3 0.000000000000000000003763 94.0
HFD2_k127_6343203_2 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 486.0
HFD2_k127_6343203_20 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000004334 87.0
HFD2_k127_6343203_21 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.00000000000002518 75.0
HFD2_k127_6343203_3 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 478.0
HFD2_k127_6343203_4 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000997 456.0
HFD2_k127_6343203_5 Proposed homoserine kinase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 437.0
HFD2_k127_6343203_6 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 418.0
HFD2_k127_6343203_7 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 411.0
HFD2_k127_6343203_8 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 380.0
HFD2_k127_6343203_9 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 375.0
HFD2_k127_6448321_0 ATPase BadF BadG BcrA BcrD type - - - 1.459e-310 981.0
HFD2_k127_6448321_1 PFAM glycosyl transferase family 51 K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 574.0
HFD2_k127_6448321_10 Protein of unknown function (DUF2400) - - - 0.0000000000000000000000000000000000000000000000003244 194.0
HFD2_k127_6448321_11 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000001918 195.0
HFD2_k127_6448321_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000001098 172.0
HFD2_k127_6448321_13 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000002132 149.0
HFD2_k127_6448321_14 SAM-dependent methyltransferase - - - 0.0000000000000000000000000000000001658 141.0
HFD2_k127_6448321_15 TIGRFAM MJ0042 family finger-like protein - - - 0.00000000000000000000000007323 121.0
HFD2_k127_6448321_16 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000001136 104.0
HFD2_k127_6448321_17 PFAM ABC transporter K01995 - - 0.000000000000000000000716 96.0
HFD2_k127_6448321_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000009124 82.0
HFD2_k127_6448321_19 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.0000000000008209 72.0
HFD2_k127_6448321_2 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 419.0
HFD2_k127_6448321_3 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 394.0
HFD2_k127_6448321_4 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 347.0
HFD2_k127_6448321_5 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 346.0
HFD2_k127_6448321_6 ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 318.0
HFD2_k127_6448321_7 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 322.0
HFD2_k127_6448321_8 3-dehydroquinate synthase (EC 4.6.1.3) K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 304.0
HFD2_k127_6448321_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000002562 220.0
HFD2_k127_6540275_0 XFP C-terminal domain K01621 - 4.1.2.22,4.1.2.9 4.057e-245 760.0
HFD2_k127_6540275_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 9.486e-202 641.0
HFD2_k127_6540275_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 381.0
HFD2_k127_6540275_4 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003138 260.0
HFD2_k127_6570239_0 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 343.0
HFD2_k127_6570239_1 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008547 344.0
HFD2_k127_6570239_10 Glycosyl transferase family 2 - - - 0.00000000000000000000000005891 122.0
HFD2_k127_6570239_11 Methionine biosynthesis protein MetW - - - 0.000000000000003112 87.0
HFD2_k127_6570239_2 PFAM methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 340.0
HFD2_k127_6570239_3 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 325.0
HFD2_k127_6570239_4 Glycosyl transferase, family 2 K16555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 293.0
HFD2_k127_6570239_5 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001857 261.0
HFD2_k127_6570239_6 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002246 284.0
HFD2_k127_6570239_7 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000002449 212.0
HFD2_k127_6570239_8 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000002755 184.0
HFD2_k127_6570239_9 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000646 135.0
HFD2_k127_6582692_0 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 524.0
HFD2_k127_6582692_1 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 513.0
HFD2_k127_6582692_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 399.0
HFD2_k127_6582692_3 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002237 266.0
HFD2_k127_6675333_0 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 481.0
HFD2_k127_6675333_1 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 449.0
HFD2_k127_6675333_10 Rubrerythrin - - - 0.00000001036 64.0
HFD2_k127_6675333_11 Glutaredoxin K03676 - - 0.00000009362 55.0
HFD2_k127_6675333_12 Sigma-54 interaction domain - - - 0.0005701 51.0
HFD2_k127_6675333_2 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 413.0
HFD2_k127_6675333_3 Ferredoxin--NADP reductase K21567 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 308.0
HFD2_k127_6675333_4 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002286 246.0
HFD2_k127_6675333_5 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000003308 247.0
HFD2_k127_6675333_6 Glyoxalase-like domain K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000007004 177.0
HFD2_k127_6675333_7 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000001012 156.0
HFD2_k127_6675333_8 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000009262 107.0
HFD2_k127_6675333_9 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000003603 72.0
HFD2_k127_69004_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671,K22345 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9,4.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 369.0
HFD2_k127_69004_1 NUDIX domain K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000004722 230.0
HFD2_k127_69004_2 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000001621 215.0
HFD2_k127_69004_3 Rhodanese Homology Domain - - - 0.000000000000000000000000000005073 124.0
HFD2_k127_69004_4 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000001672 116.0
HFD2_k127_69004_5 Domain of unknown function (DUF4282) - - - 0.000002579 57.0
HFD2_k127_6904758_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 3.743e-197 648.0
HFD2_k127_6904758_1 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 588.0
HFD2_k127_6904758_10 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000001305 198.0
HFD2_k127_6904758_11 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000004076 174.0
HFD2_k127_6904758_12 - - - - 0.00000000000000000000000000000000000000000007008 166.0
HFD2_k127_6904758_13 Belongs to the skp family K06142 - - 0.00006939 56.0
HFD2_k127_6904758_14 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00008761 51.0
HFD2_k127_6904758_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 515.0
HFD2_k127_6904758_3 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 392.0
HFD2_k127_6904758_4 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 309.0
HFD2_k127_6904758_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 307.0
HFD2_k127_6904758_6 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 312.0
HFD2_k127_6904758_7 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 296.0
HFD2_k127_6904758_8 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001132 261.0
HFD2_k127_6904758_9 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000005909 259.0
HFD2_k127_7018729_0 Domain of unknown function (DUF4105) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 503.0
HFD2_k127_7018729_1 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 429.0
HFD2_k127_7018729_10 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000001034 55.0
HFD2_k127_7018729_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 353.0
HFD2_k127_7018729_3 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 325.0
HFD2_k127_7018729_4 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000003671 244.0
HFD2_k127_7018729_5 Putative bacterial lipoprotein (DUF799) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003426 242.0
HFD2_k127_7018729_6 Protein of unknown function (DUF3015) - - - 0.00000000000000000000000000000000000001614 159.0
HFD2_k127_7018729_7 Domain of unknown function (DUF4810) - - - 0.0000000000000000000000000000003545 127.0
HFD2_k127_7018729_9 - - - - 0.00000000000000000000000006946 110.0
HFD2_k127_7025813_0 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 464.0
HFD2_k127_7025813_1 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 320.0
HFD2_k127_7025813_2 PFAM Pilus assembly protein PilO K02664 - - 0.0000000000000000000000000000000001336 148.0
HFD2_k127_7025813_3 PFAM Fimbrial assembly family protein K02663 - - 0.00000000000000000000001214 113.0
HFD2_k127_7025813_4 PFAM type II and III secretion system protein K02666 - - 0.00000000000000000000006232 111.0
HFD2_k127_7025813_5 PFAM helix-turn-helix domain protein - - - 0.00000000000000197 80.0
HFD2_k127_7025813_6 Pilus assembly protein, PilP K02665 - - 0.0000000000004203 81.0
HFD2_k127_7026828_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 7.559e-231 736.0
HFD2_k127_7026828_1 Heavy metal translocating P-type atpase K01533,K17686 - 3.6.3.4,3.6.3.54 3.587e-220 708.0
HFD2_k127_7026828_10 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002521 249.0
HFD2_k127_7026828_11 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000000000000000009698 198.0
HFD2_k127_7026828_12 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000000000000006363 153.0
HFD2_k127_7026828_13 PFAM cytochrome c, class I K00406 - - 0.0000000000000000000000000000000000000000682 156.0
HFD2_k127_7026828_14 Domain of unknown function (DUF4304) - - - 0.000000000000000000000000000000000002746 142.0
HFD2_k127_7026828_15 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000000000000000000001942 140.0
HFD2_k127_7026828_16 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000004652 130.0
HFD2_k127_7026828_17 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.0000000000000000000000002347 112.0
HFD2_k127_7026828_18 FixH - - - 0.00000000000000001357 90.0
HFD2_k127_7026828_19 - - - - 0.000000000000008892 77.0
HFD2_k127_7026828_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 394.0
HFD2_k127_7026828_21 OsmC-like protein - - - 0.0000000001102 65.0
HFD2_k127_7026828_22 Cytochrome oxidase maturation protein - - - 0.000000005044 58.0
HFD2_k127_7026828_3 enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 378.0
HFD2_k127_7026828_4 PFAM cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 355.0
HFD2_k127_7026828_5 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 351.0
HFD2_k127_7026828_6 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 324.0
HFD2_k127_7026828_7 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003386 280.0
HFD2_k127_7026828_8 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000008592 253.0
HFD2_k127_7026828_9 COG0500 SAM-dependent methyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001331 259.0
HFD2_k127_7040196_0 TRAP transporter, 4TM 12TM fusion protein - - - 3.531e-194 628.0
HFD2_k127_7040196_1 helix_turn_helix, Lux Regulon K03556 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009808 424.0
HFD2_k127_7040196_2 TRAP transporter solute receptor, TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 372.0
HFD2_k127_7040196_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000001835 95.0
HFD2_k127_7040196_5 translation initiation factor activity - - - 0.0000001598 59.0
HFD2_k127_7119558_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 569.0
HFD2_k127_7119558_1 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 491.0
HFD2_k127_7119558_2 TOBE domain K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 371.0
HFD2_k127_7119558_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 357.0
HFD2_k127_7119558_4 glycerophosphodiester transmembrane transport K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 337.0
HFD2_k127_7119558_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001449 233.0
HFD2_k127_7119558_6 membrane transporter protein K07090 - - 0.00000000000000000000003225 112.0
HFD2_k127_7136566_0 Belongs to the aconitase IPM isomerase family K01682 - 4.2.1.3,4.2.1.99 0.0 1258.0
HFD2_k127_7136566_1 alpha amylase, catalytic region - - - 6.844e-219 689.0
HFD2_k127_7136566_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 396.0
HFD2_k127_7136566_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 353.0
HFD2_k127_7136566_4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 323.0
HFD2_k127_7136566_5 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002234 287.0
HFD2_k127_7136566_6 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000008187 217.0
HFD2_k127_7136566_7 Thioesterase K07107,K12500 - - 0.00000000000000000000000000000000000000000000000000000004291 202.0
HFD2_k127_7136566_8 Heavy-metal resistance - - - 0.000000000000000000000000008176 116.0
HFD2_k127_7136566_9 regulation of microtubule-based process K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.000000000002317 79.0
HFD2_k127_71493_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 2.02e-197 628.0
HFD2_k127_71493_1 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 542.0
HFD2_k127_71493_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 496.0
HFD2_k127_71493_3 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 461.0
HFD2_k127_71493_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 443.0
HFD2_k127_71493_5 - - - - 0.000000000000000000000000000005395 131.0
HFD2_k127_71493_6 Elongation factor SelB winged helix K03833 - - 0.000000000000000000000003061 110.0
HFD2_k127_71493_7 Rhomboid family - - - 0.0000000000000000000001777 111.0
HFD2_k127_7150322_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 1.147e-288 919.0
HFD2_k127_7150322_1 Doubled CXXCH motif (Paired_CXXCH_1) - - - 5.876e-282 881.0
HFD2_k127_7150322_10 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005525 282.0
HFD2_k127_7150322_11 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000419 278.0
HFD2_k127_7150322_12 glycosyl transferase family 8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009619 281.0
HFD2_k127_7150322_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004546 269.0
HFD2_k127_7150322_14 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000008344 237.0
HFD2_k127_7150322_15 Putative bacterial lipoprotein (DUF799) - - - 0.0000000000000000000000000000000000000000000000000000000000000000223 228.0
HFD2_k127_7150322_16 Glycosyl transferase family 2 K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000001156 233.0
HFD2_k127_7150322_17 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000004541 121.0
HFD2_k127_7150322_18 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000000000000000074 90.0
HFD2_k127_7150322_19 Y_Y_Y domain - - - 0.00000000000000007635 96.0
HFD2_k127_7150322_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 567.0
HFD2_k127_7150322_20 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000002386 69.0
HFD2_k127_7150322_21 radical SAM domain protein - - - 0.000000000689 70.0
HFD2_k127_7150322_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009266 512.0
HFD2_k127_7150322_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 475.0
HFD2_k127_7150322_5 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 415.0
HFD2_k127_7150322_6 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 387.0
HFD2_k127_7150322_7 PPIC-type PPIASE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 396.0
HFD2_k127_7150322_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 323.0
HFD2_k127_7150322_9 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 290.0
HFD2_k127_7150490_0 4Fe-4S dicluster domain K00184 - - 0.0 1038.0
HFD2_k127_7150490_1 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 6.085e-197 622.0
HFD2_k127_7150490_10 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 291.0
HFD2_k127_7150490_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 288.0
HFD2_k127_7150490_12 Calcineurin-like phosphoesterase K07096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 287.0
HFD2_k127_7150490_13 Cytochrome c K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001722 285.0
HFD2_k127_7150490_14 aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000004124 274.0
HFD2_k127_7150490_15 Type II secretion system K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 271.0
HFD2_k127_7150490_16 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001659 266.0
HFD2_k127_7150490_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009264 264.0
HFD2_k127_7150490_18 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000000000000000000000000000000000000000002403 241.0
HFD2_k127_7150490_19 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000001339 225.0
HFD2_k127_7150490_2 Polysulphide reductase, NrfD K00185 - - 1.326e-195 625.0
HFD2_k127_7150490_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000003093 241.0
HFD2_k127_7150490_21 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000854 226.0
HFD2_k127_7150490_22 Heavy-metal-associated domain K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000003183 213.0
HFD2_k127_7150490_23 Vitamin K epoxide reductase family - - - 0.0000000000000000000000000000000000000000000000000000000002575 216.0
HFD2_k127_7150490_24 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000004057 210.0
HFD2_k127_7150490_25 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000002269 201.0
HFD2_k127_7150490_26 - - - - 0.000000000000000000000000000000000000000000005715 175.0
HFD2_k127_7150490_27 Cytochrome c - - - 0.000000000000000000000000000000000004352 156.0
HFD2_k127_7150490_28 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000001546 138.0
HFD2_k127_7150490_29 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000001336 131.0
HFD2_k127_7150490_3 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 546.0
HFD2_k127_7150490_30 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000007392 131.0
HFD2_k127_7150490_31 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000175 128.0
HFD2_k127_7150490_32 HD domain - - - 0.000000000000000000007965 106.0
HFD2_k127_7150490_33 cellular modified histidine biosynthetic process - - - 0.00000000000000000003892 100.0
HFD2_k127_7150490_34 PFAM Fimbrial assembly K02461 - - 0.000000000000001046 90.0
HFD2_k127_7150490_35 Putative regulatory protein - - - 0.000000000001654 71.0
HFD2_k127_7150490_36 Cytochrome c K00425,K07245,K08738 - 1.10.3.14 0.00000000004103 76.0
HFD2_k127_7150490_37 type IV pilus modification protein PilV K02458 - - 0.0000000005242 70.0
HFD2_k127_7150490_38 pilus assembly protein PilW K02459 - - 0.00000004399 63.0
HFD2_k127_7150490_39 General secretion pathway protein H K02457 - - 0.00000009464 64.0
HFD2_k127_7150490_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005054 526.0
HFD2_k127_7150490_40 - K02463 - - 0.0002599 53.0
HFD2_k127_7150490_5 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 514.0
HFD2_k127_7150490_6 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 451.0
HFD2_k127_7150490_7 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006119 407.0
HFD2_k127_7150490_8 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007758 373.0
HFD2_k127_7150490_9 Bacterial type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 356.0
HFD2_k127_7159184_0 Cytochrome c554 and c-prime - - - 2.118e-242 757.0
HFD2_k127_7159184_1 Protein of unknown function (DUF3373) - - - 9.137e-194 621.0
HFD2_k127_7159184_3 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000008119 89.0
HFD2_k127_7159184_4 Transcriptional regulator - - - 0.00001629 48.0
HFD2_k127_7176421_0 surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 326.0
HFD2_k127_7176421_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000001145 241.0
HFD2_k127_7176421_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000004708 208.0
HFD2_k127_7176421_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000001178 109.0
HFD2_k127_7176421_4 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000004344 77.0
HFD2_k127_7292531_0 B12 binding domain K00548 - 2.1.1.13 0.0 1047.0
HFD2_k127_7292531_1 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 4.384e-283 882.0
HFD2_k127_7292531_10 Glycoprotease family K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 333.0
HFD2_k127_7292531_11 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 306.0
HFD2_k127_7292531_12 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005543 299.0
HFD2_k127_7292531_13 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000001328 271.0
HFD2_k127_7292531_14 Deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007075 248.0
HFD2_k127_7292531_15 Cytochrome c554 and c-prime K03620 - - 0.000000000000000000000000000000000000000000000000000000000000000000000045 270.0
HFD2_k127_7292531_16 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008731 256.0
HFD2_k127_7292531_17 PSP1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000006557 239.0
HFD2_k127_7292531_18 PFAM Cytochrome b(N-terminal) b6 petB - - - 0.0000000000000000000000000000000000000000000000000000000000004355 222.0
HFD2_k127_7292531_19 Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions K02635 GO:0005575,GO:0005622,GO:0005623,GO:0009512,GO:0009579,GO:0016020,GO:0032991,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464,GO:0070069 - 0.000000000000000000000000000000000000000000000000000000000002399 217.0
HFD2_k127_7292531_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.363e-263 856.0
HFD2_k127_7292531_20 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000003728 211.0
HFD2_k127_7292531_21 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000002819 205.0
HFD2_k127_7292531_22 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000002219 174.0
HFD2_k127_7292531_23 DNA polymerase III, delta subunit, C terminal K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000001307 174.0
HFD2_k127_7292531_24 Cytochrome b subunit of formate dehydrogenase-like protein - - - 0.000000000000000000000000000000000000000005145 166.0
HFD2_k127_7292531_25 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.000000000000000000000000000000000000001053 155.0
HFD2_k127_7292531_26 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000000000000000000000000000888 153.0
HFD2_k127_7292531_27 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000001045 159.0
HFD2_k127_7292531_28 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000001348 132.0
HFD2_k127_7292531_29 - - - - 0.000000000000000000000000000001422 128.0
HFD2_k127_7292531_3 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 2.455e-220 694.0
HFD2_k127_7292531_30 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000001098 127.0
HFD2_k127_7292531_31 Belongs to the Fur family K09825 - - 0.00000000000000000000006918 102.0
HFD2_k127_7292531_32 PFAM amidohydrolase K20810 - 3.5.4.40 0.0000000000000000000008934 104.0
HFD2_k127_7292531_33 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.000000000000000000006441 97.0
HFD2_k127_7292531_34 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000000003135 86.0
HFD2_k127_7292531_35 Rieske [2Fe-2S] domain - - - 0.000000000005985 75.0
HFD2_k127_7292531_36 TonB C terminal - - - 0.0002215 52.0
HFD2_k127_7292531_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 555.0
HFD2_k127_7292531_5 SMART Nucleotide binding protein, PINc K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 547.0
HFD2_k127_7292531_6 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 520.0
HFD2_k127_7292531_7 denitrification pathway K02569,K15876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008175 421.0
HFD2_k127_7292531_8 denitrification pathway K02569,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 368.0
HFD2_k127_7292531_9 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 334.0
HFD2_k127_7417885_0 response regulator K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 479.0
HFD2_k127_7417885_1 PAS domain K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 478.0
HFD2_k127_7417885_10 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000000000003484 158.0
HFD2_k127_7417885_11 COG NOG14600 non supervised orthologous group - - - 0.00000000000000000000000000000003325 125.0
HFD2_k127_7417885_12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000001925 128.0
HFD2_k127_7417885_13 Type II secretion system protein F domain-containing protein 1 K12510 - - 0.00000000000000000000008193 114.0
HFD2_k127_7417885_14 Protein of unknown function (DUF2905) - - - 0.000000000000000000003174 94.0
HFD2_k127_7417885_15 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.0000000000001942 82.0
HFD2_k127_7417885_16 Domain of unknown function (DUF4390) - - - 0.000000000001254 76.0
HFD2_k127_7417885_19 Type II secretion system (T2SS), protein F K12510 - - 0.00000007318 63.0
HFD2_k127_7417885_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 455.0
HFD2_k127_7417885_20 COG NOG14600 non supervised orthologous group - - - 0.0000003037 53.0
HFD2_k127_7417885_3 Type II IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 426.0
HFD2_k127_7417885_4 regulation of RNA biosynthetic process - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 317.0
HFD2_k127_7417885_5 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003622 292.0
HFD2_k127_7417885_6 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000004332 241.0
HFD2_k127_7417885_7 Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000000004472 210.0
HFD2_k127_7417885_8 Pilus formation protein N terminal region K02280 - - 0.0000000000000000000000000000000000000000000000000004281 203.0
HFD2_k127_7436655_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 5.074e-282 880.0
HFD2_k127_7436655_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 535.0
HFD2_k127_7436655_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 473.0
HFD2_k127_7436655_3 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 406.0
HFD2_k127_7436655_4 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 298.0
HFD2_k127_7436655_5 Flagellar hook protein flgE - - - 0.000000000000000000000000000000000000000000000000000000000002443 229.0
HFD2_k127_7436655_6 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000001154 224.0
HFD2_k127_7436655_7 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000001431 130.0
HFD2_k127_7436655_8 - - - - 0.0000000000000008957 83.0
HFD2_k127_7436655_9 RelB antitoxin K07473 - - 0.000000000000005063 81.0
HFD2_k127_7509079_0 CoA binding domain K09181 - - 0.0 1116.0
HFD2_k127_7509079_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain - - - 0.0 1070.0
HFD2_k127_7509079_10 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 475.0
HFD2_k127_7509079_11 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 416.0
HFD2_k127_7509079_12 PFAM Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 419.0
HFD2_k127_7509079_13 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074,K15016 - 1.1.1.157,1.1.1.35,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 419.0
HFD2_k127_7509079_14 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 392.0
HFD2_k127_7509079_15 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 356.0
HFD2_k127_7509079_16 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 351.0
HFD2_k127_7509079_17 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 325.0
HFD2_k127_7509079_18 ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000009239 229.0
HFD2_k127_7509079_19 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000001603 198.0
HFD2_k127_7509079_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.967e-231 731.0
HFD2_k127_7509079_20 Thioesterase K01075,K07107,K12073 - 3.1.2.23,3.1.2.28 0.00000000000003565 83.0
HFD2_k127_7509079_21 Belongs to the UPF0102 family K07460 - - 0.00006446 47.0
HFD2_k127_7509079_3 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 1.745e-230 719.0
HFD2_k127_7509079_4 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 8.292e-228 717.0
HFD2_k127_7509079_5 Belongs to the thiolase family - - - 6.627e-220 686.0
HFD2_k127_7509079_6 AMP-binding enzyme C-terminal domain - - - 3.61e-217 685.0
HFD2_k127_7509079_7 Alanine dehydrogenase/PNT, C-terminal domain K07538 - 1.1.1.368 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008277 580.0
HFD2_k127_7509079_8 Amino acid amide ABC transporter substrate-binding protein, HAAT family K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 541.0
HFD2_k127_7509079_9 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 511.0
HFD2_k127_7633075_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 3.541e-317 978.0
HFD2_k127_7633075_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005932 561.0
HFD2_k127_7633075_10 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 369.0
HFD2_k127_7633075_11 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 331.0
HFD2_k127_7633075_12 Quinohemoprotein amine dehydrogenase, alpha subunit domain II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 322.0
HFD2_k127_7633075_13 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 314.0
HFD2_k127_7633075_14 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003471 286.0
HFD2_k127_7633075_15 Radical SAM superfamily K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000255 287.0
HFD2_k127_7633075_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000405 274.0
HFD2_k127_7633075_17 Enoyl-(Acyl carrier protein) reductase K00059,K00068 - 1.1.1.100,1.1.1.140 0.0000000000000000000000000000000000000000000000000000000000000000000000156 253.0
HFD2_k127_7633075_18 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000003098 254.0
HFD2_k127_7633075_19 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000002477 218.0
HFD2_k127_7633075_2 PASTA domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 533.0
HFD2_k127_7633075_20 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000001332 214.0
HFD2_k127_7633075_21 Belongs to the pyrroline-5-carboxylate reductase family K00286 GO:0003674,GO:0003824,GO:0004735,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009651,GO:0016491,GO:0016645,GO:0016646,GO:0030312,GO:0044424,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.5.1.2 0.00000000000000000000000000000000000000000000000000000002874 211.0
HFD2_k127_7633075_22 Maf-like protein K06287 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000006191 170.0
HFD2_k127_7633075_23 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000001266 163.0
HFD2_k127_7633075_24 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000000000005127 158.0
HFD2_k127_7633075_25 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000003277 139.0
HFD2_k127_7633075_26 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000003237 134.0
HFD2_k127_7633075_27 Reverse transcriptase-like K03469,K06864,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.00000000000000000000000000000006456 133.0
HFD2_k127_7633075_28 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000002629 132.0
HFD2_k127_7633075_29 Essential cell division protein K03589 - - 0.000000000000000000000000000001706 131.0
HFD2_k127_7633075_3 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 502.0
HFD2_k127_7633075_30 YGGT family K02221 - - 0.000000000000000000000000000004446 122.0
HFD2_k127_7633075_31 - - - - 0.00000000000000000000000006375 113.0
HFD2_k127_7633075_32 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000001517 99.0
HFD2_k127_7633075_33 Belongs to the UPF0235 family K09131 - - 0.00000000000000000003594 97.0
HFD2_k127_7633075_34 Quinohemoprotein amine dehydrogenase - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000001152 89.0
HFD2_k127_7633075_35 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000004715 78.0
HFD2_k127_7633075_37 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00008937 55.0
HFD2_k127_7633075_38 cell division K03586 GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944 - 0.0005903 52.0
HFD2_k127_7633075_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 432.0
HFD2_k127_7633075_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 431.0
HFD2_k127_7633075_6 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 414.0
HFD2_k127_7633075_7 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 410.0
HFD2_k127_7633075_8 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 363.0
HFD2_k127_7633075_9 Mur ligase middle domain K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 363.0
HFD2_k127_7677286_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1688.0
HFD2_k127_7677286_1 PFAM Outer membrane efflux protein K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 604.0
HFD2_k127_7677286_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 504.0
HFD2_k127_7677286_3 PFAM Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 290.0
HFD2_k127_7677286_4 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.00000000000000006981 90.0
HFD2_k127_7719900_0 Capsule synthesis protein K07282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001374 258.0
HFD2_k127_7719900_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000002951 230.0
HFD2_k127_7719900_2 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000006341 215.0
HFD2_k127_7719900_3 LysM domain K01449,K19223 - 3.5.1.28 0.000000000000000000000000000000000000000000000000001624 194.0
HFD2_k127_7719900_4 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000001211 174.0
HFD2_k127_7719900_5 Amidohydrolase family K20810 - 3.5.4.40 0.00000000000000000000000000000000000023 150.0
HFD2_k127_7719900_6 DinB superfamily - - - 0.000000000006362 68.0
HFD2_k127_7722450_0 ABC-type branched-chain amino acid transport K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 542.0
HFD2_k127_7722450_1 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 389.0
HFD2_k127_7722450_2 transport system permease K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 353.0
HFD2_k127_7722450_3 Abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 304.0
HFD2_k127_7722450_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006073 287.0
HFD2_k127_7822025_0 Molybdopterin oxidoreductase Fe4S4 domain K00370 - 1.7.5.1 0.0 1940.0
HFD2_k127_7822025_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1293.0
HFD2_k127_7822025_10 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000001255 123.0
HFD2_k127_7822025_11 Cytochrome c - - - 0.0000000000000000006433 93.0
HFD2_k127_7822025_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000001022 61.0
HFD2_k127_7822025_13 PFAM Uncharacterised protein family UPF0150 - - - 0.000000006336 59.0
HFD2_k127_7822025_2 Nitrate reductase, beta subunit K00371,K17051 - 1.7.5.1 1.232e-224 705.0
HFD2_k127_7822025_3 Transporter K02575 - - 5.145e-196 620.0
HFD2_k127_7822025_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03753,K13818 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000001428 250.0
HFD2_k127_7822025_5 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
HFD2_k127_7822025_6 nitrate reductase activity K00370,K00374,K02575 GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000004719 251.0
HFD2_k127_7822025_7 PFAM ATP-binding region, ATPase domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000009356 187.0
HFD2_k127_7822025_8 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000001375 141.0
HFD2_k127_7822025_9 Nitrate reductase delta subunit K00373 - - 0.0000000000000000000000000000000003818 138.0
HFD2_k127_7845890_0 associated with various cellular activities K03695,K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 554.0
HFD2_k127_7845890_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 478.0
HFD2_k127_7845890_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K02405 - - 0.0000000000000000000000000000000000000000000000000000000000002288 221.0
HFD2_k127_7845890_11 Thioesterase K18700 - 3.1.2.29 0.0000000000000000000000000000000000000000000000000303 189.0
HFD2_k127_7845890_12 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000000000000000006862 183.0
HFD2_k127_7845890_13 RmuC family K09760 - - 0.0000000000000000000000000000000003368 146.0
HFD2_k127_7845890_14 Zincin-like metallopeptidase - - - 0.0000000000000000000000000000000221 131.0
HFD2_k127_7845890_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 488.0
HFD2_k127_7845890_3 phosphorelay signal transduction system K10941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 426.0
HFD2_k127_7845890_4 HlyD family secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 377.0
HFD2_k127_7845890_5 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 383.0
HFD2_k127_7845890_6 PFAM PfkB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 358.0
HFD2_k127_7845890_7 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 357.0
HFD2_k127_7845890_8 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000001096 280.0
HFD2_k127_7845890_9 PFAM Aminotransferase class I and II K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002069 259.0
HFD2_k127_7892346_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 495.0
HFD2_k127_7892346_1 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 284.0
HFD2_k127_7892346_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000001554 224.0
HFD2_k127_7892346_3 - - - - 0.000000000000000000000000000000000000001796 148.0
HFD2_k127_7892346_4 - - - - 0.00000000000000000000000000000000004105 147.0
HFD2_k127_7892346_5 membrane transporter protein K07090 - - 0.000000000000000000000000003116 115.0
HFD2_k127_7892346_6 - - - - 0.0000003262 52.0
HFD2_k127_7892346_7 Belongs to the 'phage' integrase family - - - 0.0002003 45.0
HFD2_k127_7894392_0 Pfam SNARE associated Golgi protein - - - 7.188e-247 781.0
HFD2_k127_7894392_1 Phospholipase D. Active site motifs. K06132 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 577.0
HFD2_k127_7894392_2 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 370.0
HFD2_k127_7894392_3 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001097 280.0
HFD2_k127_7894392_4 Zinc-binding dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001171 265.0
HFD2_k127_7894392_5 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007888 267.0
HFD2_k127_7894392_6 endonuclease exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000027 209.0
HFD2_k127_7894392_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000001082 185.0
HFD2_k127_7894392_8 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000001952 113.0
HFD2_k127_7894392_9 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.00000000000000000000003562 108.0
HFD2_k127_7895504_0 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 349.0
HFD2_k127_7895504_1 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000005984 249.0
HFD2_k127_7895504_10 Putative zinc-finger - - - 0.0004157 50.0
HFD2_k127_7895504_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000001037 179.0
HFD2_k127_7895504_3 PKD domain containing protein K01337,K20276,K21449 - 3.4.21.50 0.00000000000000000000000000000000000000000007107 177.0
HFD2_k127_7895504_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000004215 117.0
HFD2_k127_7895504_5 Domain of unknown function DUF302 - - - 0.000000000000000000000009207 107.0
HFD2_k127_7895504_6 Protein of unknown function (DUF2892) - - - 0.00000000000000001672 83.0
HFD2_k127_7895504_7 Rubrerythrin - - - 0.0000000000005499 76.0
HFD2_k127_7895504_8 Protein of unknown function (DUF3106) - - - 0.00002123 55.0
HFD2_k127_7895504_9 TIGRFAM regulatory protein, FmdB - - - 0.0003293 49.0
HFD2_k127_7897318_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 7.277e-290 904.0
HFD2_k127_7897318_1 NAD(P) transhydrogenase beta subunit K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 621.0
HFD2_k127_7897318_10 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 321.0
HFD2_k127_7897318_11 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 286.0
HFD2_k127_7897318_12 Major Facilitator Superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008288 291.0
HFD2_k127_7897318_13 AAA domain, putative AbiEii toxin, Type IV TA system K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006191 261.0
HFD2_k127_7897318_14 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000001548 233.0
HFD2_k127_7897318_15 - - - - 0.00000000000000000000000000000000000000000000000000000000007873 213.0
HFD2_k127_7897318_16 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000001423 198.0
HFD2_k127_7897318_17 intermembrane phospholipid transfer K07323 - - 0.00000000000000000000000000000000000000000000000000004444 194.0
HFD2_k127_7897318_18 Putative bacterial lipoprotein (DUF799) - - - 0.0000000000000000000000000000000000000000000000002759 186.0
HFD2_k127_7897318_19 PFAM Mammalian cell entry related domain protein K02067 - - 0.00000000000000000000000000000000000000000009757 175.0
HFD2_k127_7897318_2 PFAM Class II aldolase K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 578.0
HFD2_k127_7897318_20 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000171 147.0
HFD2_k127_7897318_21 spectrin binding - - - 0.00000000000000000000000000000000004716 152.0
HFD2_k127_7897318_22 NADP transhydrogenase K00324 - 1.6.1.2 0.0000000000000000000000000000003826 124.0
HFD2_k127_7897318_23 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.00000000000000000000000000001702 126.0
HFD2_k127_7897318_24 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.0000000000000000000000000003819 124.0
HFD2_k127_7897318_25 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000196 104.0
HFD2_k127_7897318_26 Dodecin K09165 - - 0.000000000000000000001352 98.0
HFD2_k127_7897318_27 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000002315 104.0
HFD2_k127_7897318_29 PFAM pentapeptide repeat protein - - - 0.00000000002798 75.0
HFD2_k127_7897318_3 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 537.0
HFD2_k127_7897318_30 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K13810 - 2.2.1.2,5.3.1.9 0.0000000002787 67.0
HFD2_k127_7897318_4 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 452.0
HFD2_k127_7897318_5 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 455.0
HFD2_k127_7897318_6 PFAM Alanine dehydrogenase PNT, C-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 399.0
HFD2_k127_7897318_7 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 379.0
HFD2_k127_7897318_8 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 362.0
HFD2_k127_7897318_9 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 323.0
HFD2_k127_7899112_0 bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 616.0
HFD2_k127_7899112_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 501.0
HFD2_k127_7899112_2 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000003336 175.0
HFD2_k127_7899112_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000001301 164.0
HFD2_k127_7899112_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000008133 149.0
HFD2_k127_7899437_0 TIGRFAM Ammonium transporter K03320 - - 5.699e-246 770.0
HFD2_k127_7899437_1 TIGRFAM iron-sulfur cluster binding protein K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 459.0
HFD2_k127_7899437_10 - - - - 0.00000000000000000004142 93.0
HFD2_k127_7899437_11 PFAM Uncharacterised ACR, YkgG family COG1556 K00782 - - 0.00000000000008932 81.0
HFD2_k127_7899437_12 thiamine diphosphate biosynthetic process K03154 - - 0.0000000004914 62.0
HFD2_k127_7899437_13 Cytochrome c - - - 0.0001267 49.0
HFD2_k127_7899437_2 PFAM NAD-dependent epimerase dehydratase K01784,K02473 - 5.1.3.2,5.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 401.0
HFD2_k127_7899437_3 Phosphoadenosine phosphosulfate reductase family K21947 - 2.8.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 325.0
HFD2_k127_7899437_4 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002986 275.0
HFD2_k127_7899437_5 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 273.0
HFD2_k127_7899437_6 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000003624 269.0
HFD2_k127_7899437_7 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000007113 174.0
HFD2_k127_7899437_8 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000003785 173.0
HFD2_k127_7899437_9 Transposase IS200 like - - - 0.000000000000000000000000000000000000000006176 167.0
HFD2_k127_7900361_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.186e-207 675.0
HFD2_k127_7900361_1 pfam fad - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 544.0
HFD2_k127_7900361_10 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000001609 157.0
HFD2_k127_7900361_11 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000006121 164.0
HFD2_k127_7900361_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000002056 124.0
HFD2_k127_7900361_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 516.0
HFD2_k127_7900361_3 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 439.0
HFD2_k127_7900361_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 435.0
HFD2_k127_7900361_5 nitrogen compound transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009796 343.0
HFD2_k127_7900361_6 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 338.0
HFD2_k127_7900361_7 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 330.0
HFD2_k127_7900361_8 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 331.0
HFD2_k127_7900361_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006426 242.0
HFD2_k127_7906557_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.128e-267 836.0
HFD2_k127_7906557_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 7.369e-261 822.0
HFD2_k127_7906557_10 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003833 276.0
HFD2_k127_7906557_11 Formyl transferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002378 258.0
HFD2_k127_7906557_12 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000003032 234.0
HFD2_k127_7906557_13 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000001403 194.0
HFD2_k127_7906557_14 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000001232 192.0
HFD2_k127_7906557_15 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000002286 183.0
HFD2_k127_7906557_16 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000003379 177.0
HFD2_k127_7906557_17 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000003943 167.0
HFD2_k127_7906557_18 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000005036 183.0
HFD2_k127_7906557_19 Domain of unknown function (DUF4416) - - - 0.00000000000000000000000000000000000000004233 166.0
HFD2_k127_7906557_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.555e-224 710.0
HFD2_k127_7906557_20 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000006059 155.0
HFD2_k127_7906557_21 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000008439 138.0
HFD2_k127_7906557_22 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000005982 102.0
HFD2_k127_7906557_23 Trm112p-like protein K09791 - - 0.0000000000000001237 80.0
HFD2_k127_7906557_24 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.000000000000002767 77.0
HFD2_k127_7906557_25 DUF218 domain - - - 0.0000000000004237 81.0
HFD2_k127_7906557_26 Protein of unknown function (DUF3108) - - - 0.00000000005393 75.0
HFD2_k127_7906557_27 Protein of unknown function (DUF3047) - - - 0.0006783 51.0
HFD2_k127_7906557_3 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 1.893e-206 666.0
HFD2_k127_7906557_4 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008552 505.0
HFD2_k127_7906557_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 502.0
HFD2_k127_7906557_6 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 411.0
HFD2_k127_7906557_7 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 396.0
HFD2_k127_7906557_8 PFAM outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 326.0
HFD2_k127_7906557_9 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000468 300.0
HFD2_k127_7910426_0 Fructose-1,6-bisphosphatase K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007917 566.0
HFD2_k127_7910426_1 Male sterility protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 346.0
HFD2_k127_7910426_2 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002608 280.0
HFD2_k127_7910426_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000133 113.0
HFD2_k127_7910426_4 - - - - 0.00000009365 57.0
HFD2_k127_7940416_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1489.0
HFD2_k127_7940416_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.391e-270 844.0
HFD2_k127_7940416_10 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 459.0
HFD2_k127_7940416_11 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 459.0
HFD2_k127_7940416_12 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 460.0
HFD2_k127_7940416_13 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 437.0
HFD2_k127_7940416_14 Ribosomal Proteins L2, C-terminal domain K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005212 403.0
HFD2_k127_7940416_15 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 374.0
HFD2_k127_7940416_16 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 370.0
HFD2_k127_7940416_17 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 355.0
HFD2_k127_7940416_18 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 340.0
HFD2_k127_7940416_19 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 315.0
HFD2_k127_7940416_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 5.281e-201 647.0
HFD2_k127_7940416_20 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 305.0
HFD2_k127_7940416_21 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008056 300.0
HFD2_k127_7940416_22 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 297.0
HFD2_k127_7940416_23 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001873 276.0
HFD2_k127_7940416_24 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000006735 273.0
HFD2_k127_7940416_25 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002164 250.0
HFD2_k127_7940416_26 TIGRFAM signal peptidase I K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000004483 248.0
HFD2_k127_7940416_27 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000449 241.0
HFD2_k127_7940416_28 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000003432 226.0
HFD2_k127_7940416_29 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000006614 229.0
HFD2_k127_7940416_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 5.507e-199 646.0
HFD2_k127_7940416_30 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000002188 229.0
HFD2_k127_7940416_31 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000001487 219.0
HFD2_k127_7940416_32 Mur ligase, middle domain protein K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000005071 231.0
HFD2_k127_7940416_33 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000009625 222.0
HFD2_k127_7940416_34 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000197 211.0
HFD2_k127_7940416_35 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000003257 210.0
HFD2_k127_7940416_36 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000003977 227.0
HFD2_k127_7940416_37 PFAM iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000000001098 207.0
HFD2_k127_7940416_38 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002816 205.0
HFD2_k127_7940416_39 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000007252 192.0
HFD2_k127_7940416_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 602.0
HFD2_k127_7940416_40 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000004641 189.0
HFD2_k127_7940416_41 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000009373 185.0
HFD2_k127_7940416_42 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000008529 171.0
HFD2_k127_7940416_43 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000001028 170.0
HFD2_k127_7940416_44 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000002601 159.0
HFD2_k127_7940416_45 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000009418 153.0
HFD2_k127_7940416_46 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000037 147.0
HFD2_k127_7940416_47 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000002153 144.0
HFD2_k127_7940416_48 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000000000000008385 136.0
HFD2_k127_7940416_49 Diguanylate cyclase - - - 0.0000000000000000000000000000000000129 156.0
HFD2_k127_7940416_5 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 556.0
HFD2_k127_7940416_50 Ribosomal proteins 50S L24/mitochondrial 39S L24 K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000003184 135.0
HFD2_k127_7940416_51 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000006634 124.0
HFD2_k127_7940416_52 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000001372 117.0
HFD2_k127_7940416_53 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000003187 118.0
HFD2_k127_7940416_54 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000002389 105.0
HFD2_k127_7940416_55 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000002411 111.0
HFD2_k127_7940416_56 'Cold-shock' DNA-binding domain K03704 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000716 96.0
HFD2_k127_7940416_57 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000002472 75.0
HFD2_k127_7940416_58 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000001667 73.0
HFD2_k127_7940416_59 Ribosomal protein L30p/L7e K02907 - - 0.00000000006393 71.0
HFD2_k127_7940416_6 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 546.0
HFD2_k127_7940416_60 PEGA domain - - - 0.00000001462 67.0
HFD2_k127_7940416_61 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000002216 54.0
HFD2_k127_7940416_62 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00002869 48.0
HFD2_k127_7940416_63 - - - - 0.000946 44.0
HFD2_k127_7940416_7 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 503.0
HFD2_k127_7940416_8 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 498.0
HFD2_k127_7940416_9 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 483.0
HFD2_k127_7940573_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1959.0
HFD2_k127_7940573_1 RNA polymerase beta subunit external 1 domain K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1773.0
HFD2_k127_7940573_10 Ribosomal protein L10 K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000397 138.0
HFD2_k127_7940573_11 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000004218 84.0
HFD2_k127_7940573_12 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000002472 75.0
HFD2_k127_7940573_13 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000000001485 72.0
HFD2_k127_7940573_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 8.162e-286 893.0
HFD2_k127_7940573_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 452.0
HFD2_k127_7940573_4 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 321.0
HFD2_k127_7940573_5 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000001395 247.0
HFD2_k127_7940573_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000005952 221.0
HFD2_k127_7940573_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000008257 214.0
HFD2_k127_7940573_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000006706 210.0
HFD2_k127_7940573_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000005705 161.0
HFD2_k127_7963539_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1517.0
HFD2_k127_7963539_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 440.0
HFD2_k127_7963539_2 HlyD family secretion protein K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 361.0
HFD2_k127_7963539_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000001755 224.0
HFD2_k127_7963539_4 Domain of unknown function (DUF4118) - - - 0.0000000000000000000001718 102.0
HFD2_k127_7963539_5 - - - - 0.00000000000000004565 89.0
HFD2_k127_7963539_6 - - - - 0.00000000000000639 75.0
HFD2_k127_7965240_0 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 497.0
HFD2_k127_7965240_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 506.0
HFD2_k127_7965240_2 PFAM Branched-chain amino acid transport system permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 439.0
HFD2_k127_7965240_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 383.0
HFD2_k127_7965240_4 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 364.0
HFD2_k127_7965240_5 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 343.0
HFD2_k127_7965240_6 4Fe-4S dicluster domain K00124 GO:0005575,GO:0005623,GO:0009326,GO:0032991,GO:0042597,GO:0044464,GO:1902494 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 308.0
HFD2_k127_7965240_7 Prokaryotic cytochrome b561 K00127 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002034 273.0
HFD2_k127_7965240_8 PFAM ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008907 247.0
HFD2_k127_7986749_0 4Fe-4S dicluster domain K18930 - - 0.0 1159.0
HFD2_k127_7986749_1 Pfam:DUF162 K18929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 552.0
HFD2_k127_7986749_10 branched-chain amino acid K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002924 270.0
HFD2_k127_7986749_11 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000003998 257.0
HFD2_k127_7986749_12 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000003029 245.0
HFD2_k127_7986749_13 abc transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000002664 228.0
HFD2_k127_7986749_14 LUD domain K00782 - - 0.00000000000000000000000000000000000000025 159.0
HFD2_k127_7986749_15 protocatechuate 3,4-dioxygenase activity K03381 - 1.13.11.1 0.00000000000000000000000000000003224 129.0
HFD2_k127_7986749_16 PFAM ATP-binding region ATPase domain protein - - - 0.0000418 49.0
HFD2_k127_7986749_2 Belongs to the bacterial solute-binding protein 3 family K02030,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 432.0
HFD2_k127_7986749_3 PFAM ABC transporter related K02028,K10004 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 413.0
HFD2_k127_7986749_4 (2R)-phospho-3-sulfolactate synthase (ComA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006162 420.0
HFD2_k127_7986749_5 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K10003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 362.0
HFD2_k127_7986749_6 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K10002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 349.0
HFD2_k127_7986749_7 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 332.0
HFD2_k127_7986749_8 Regulatory protein GntR HTH K05799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 305.0
HFD2_k127_7986749_9 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001272 278.0
HFD2_k127_7992132_0 DNA polymerase K02347 - - 2.298e-206 657.0
HFD2_k127_7992132_1 Amino acid permease - - - 4.504e-201 647.0
HFD2_k127_7992132_10 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 385.0
HFD2_k127_7992132_11 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 368.0
HFD2_k127_7992132_12 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 364.0
HFD2_k127_7992132_13 RmlD substrate binding domain K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 337.0
HFD2_k127_7992132_14 His Kinase A (phosphoacceptor) domain K10125 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 345.0
HFD2_k127_7992132_15 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 302.0
HFD2_k127_7992132_16 Inositol monophosphatase K01082,K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 295.0
HFD2_k127_7992132_17 PFAM glycosyl transferase family 9 K02841 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 293.0
HFD2_k127_7992132_18 Glycosyl transferase family 2 K13005 - 2.4.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001685 299.0
HFD2_k127_7992132_19 pfam abc K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007351 274.0
HFD2_k127_7992132_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 609.0
HFD2_k127_7992132_20 Glycosyl transferase, family 2 - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002556 271.0
HFD2_k127_7992132_21 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004369 258.0
HFD2_k127_7992132_22 Glycosyl transferase family 2 K12984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000224 249.0
HFD2_k127_7992132_23 cobalt ion transport K02007 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000002718 244.0
HFD2_k127_7992132_24 Glycosyltransferase family 10 (fucosyltransferase) C-term K20151 - 2.4.1.152,2.4.1.65 0.00000000000000000000000000000000000000000000000000000000000000000006526 243.0
HFD2_k127_7992132_25 Glycosyl transferase, family 9 K02841,K02843,K02847,K02849,K21003 - - 0.0000000000000000000000000000000000000000000000000000000000000002556 233.0
HFD2_k127_7992132_26 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.000000000000000000000000000000000000000000000001183 189.0
HFD2_k127_7992132_27 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000004631 169.0
HFD2_k127_7992132_28 phosphinothricin N-acetyltransferase activity - - - 0.00000000000000000000000000000000000000001198 160.0
HFD2_k127_7992132_29 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000001209 158.0
HFD2_k127_7992132_3 Mycolic acid cyclopropane synthetase K00574,K20238 - 2.1.1.317,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 532.0
HFD2_k127_7992132_30 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000006911 153.0
HFD2_k127_7992132_31 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000001972 141.0
HFD2_k127_7992132_32 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000003014 139.0
HFD2_k127_7992132_33 Cobalt transport protein K02008 - - 0.000000000000000000000000000000346 138.0
HFD2_k127_7992132_34 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000000000000000007499 123.0
HFD2_k127_7992132_35 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000002603 110.0
HFD2_k127_7992132_36 - - - - 0.0000000000000000003705 88.0
HFD2_k127_7992132_37 Rubrerythrin - - - 0.0000000000000000005672 93.0
HFD2_k127_7992132_38 Rubrerythrin - - - 0.000000000000002017 83.0
HFD2_k127_7992132_39 Cytochrome c554 and c-prime - - - 0.000000000000002448 85.0
HFD2_k127_7992132_4 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 521.0
HFD2_k127_7992132_40 cobalt ion transport K02009 - - 0.000000000000004726 87.0
HFD2_k127_7992132_41 Periplasmic protein TonB links inner and outer membranes K03832 - - 0.000000000009485 69.0
HFD2_k127_7992132_42 PFAM YcfA family protein - - - 0.0000000009256 63.0
HFD2_k127_7992132_43 PFAM Flavin reductase like domain - - - 0.0000001342 63.0
HFD2_k127_7992132_44 PFAM Methyltransferase type 11 - - - 0.000000447 62.0
HFD2_k127_7992132_45 uncharacterised conserved protein UCP017998 - - - 0.000002085 59.0
HFD2_k127_7992132_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 532.0
HFD2_k127_7992132_6 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 481.0
HFD2_k127_7992132_7 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 429.0
HFD2_k127_7992132_8 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 426.0
HFD2_k127_7992132_9 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 426.0
HFD2_k127_8278192_0 AcrB/AcrD/AcrF family - - - 0.0 1502.0
HFD2_k127_8278192_1 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 488.0
HFD2_k127_8278192_2 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 425.0
HFD2_k127_8278192_3 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 388.0
HFD2_k127_8278192_4 MlaD protein K06192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000038 254.0
HFD2_k127_8278192_5 ABC-type transport auxiliary lipoprotein component K09857 - - 0.000000000000000000000000000001611 128.0
HFD2_k127_8278192_6 Aldehyde ferredoxin oxidoreductase, N-terminal domain K11389 - 1.2.7.6 0.00000000000007347 71.0
HFD2_k127_8407223_0 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K00404,K15862 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 481.0
HFD2_k127_8407223_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 318.0
HFD2_k127_8407223_2 Domain of unknown function K00560 GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046073,GO:0046385,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.0000005554 51.0
HFD2_k127_8463083_0 Domain of Unknown Function (DUF748) - - - 2.467e-264 852.0
HFD2_k127_8463083_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.086e-218 706.0
HFD2_k127_8463083_2 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 456.0
HFD2_k127_8463083_3 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 386.0
HFD2_k127_8463083_4 ABC-2 type transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 346.0
HFD2_k127_8463083_5 Similarity to COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains(Evalue K21405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004834 262.0
HFD2_k127_8463083_6 chlorophyll binding K03286,K03640 - - 0.0000000000000000000000000000000000000000000000000000000009639 214.0
HFD2_k127_8463083_7 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.000000000000000000000000000000000000000000000000000002792 193.0
HFD2_k127_8541017_0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - 4.314e-223 713.0
HFD2_k127_8541017_1 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 611.0
HFD2_k127_8541017_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000001457 236.0
HFD2_k127_8541017_11 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000244 229.0
HFD2_k127_8541017_12 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000004044 202.0
HFD2_k127_8541017_13 Domain of unknown function - - - 0.000000000000000000000000000000000000000000001038 178.0
HFD2_k127_8541017_14 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000001335 184.0
HFD2_k127_8541017_15 PFAM LmbE family protein K18455 - 3.5.1.115 0.00000000000000000000000000000000000177 155.0
HFD2_k127_8541017_16 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000001035 112.0
HFD2_k127_8541017_17 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000001206 115.0
HFD2_k127_8541017_18 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000001394 99.0
HFD2_k127_8541017_2 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 580.0
HFD2_k127_8541017_3 CO dehydrogenase/acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 408.0
HFD2_k127_8541017_4 PFAM ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 369.0
HFD2_k127_8541017_5 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 351.0
HFD2_k127_8541017_6 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 308.0
HFD2_k127_8541017_7 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 297.0
HFD2_k127_8541017_8 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005145 281.0
HFD2_k127_8541017_9 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000308 252.0
HFD2_k127_857440_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 5.357e-246 771.0
HFD2_k127_857440_1 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 607.0
HFD2_k127_857440_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001346 267.0
HFD2_k127_857440_3 L,D-transpeptidase catalytic domain K16291 - - 0.0000000000000000000000000000000000000000000000037 186.0
HFD2_k127_857440_4 - - - - 0.00000000000000000000000000000000000000000000106 172.0
HFD2_k127_8601184_0 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 515.0
HFD2_k127_8601184_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 437.0
HFD2_k127_8601184_10 Belongs to the RtcB family K14415 - 6.5.1.3 0.0000000000000000000000001145 106.0
HFD2_k127_8601184_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 386.0
HFD2_k127_8601184_3 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00162,K00627 - 1.2.4.1,2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 354.0
HFD2_k127_8601184_4 cobalamin synthesis protein, P47K - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 326.0
HFD2_k127_8601184_5 Polypeptide deformylase K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000004788 199.0
HFD2_k127_8601184_6 helix_turn_helix, cAMP Regulatory protein K01420,K21563 - - 0.00000000000000000000000000000000000000000000000000004471 195.0
HFD2_k127_8601184_7 ACT domain K03567 - - 0.0000000000000000000000000000000000000000000000001005 184.0
HFD2_k127_8601184_8 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042,K18121 - 1.1.1.31,1.1.1.60,1.1.1.79 0.000000000000000000000000000000000000000000000002126 183.0
HFD2_k127_8601184_9 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000000000003484 166.0
HFD2_k127_883087_0 Belongs to the thiolase family K00626 - 2.3.1.9 2.049e-214 673.0
HFD2_k127_883087_1 Glycosyl hydrolase family 57 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 489.0
HFD2_k127_883087_10 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.0000000000000000000000000000000000000000000000000000000000008005 212.0
HFD2_k127_883087_11 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000597 191.0
HFD2_k127_883087_12 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000007172 208.0
HFD2_k127_883087_13 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000009761 200.0
HFD2_k127_883087_14 Protein conserved in bacteria - - - 0.000000000000002973 86.0
HFD2_k127_883087_15 Diguanylate cyclase - - - 0.0000000005201 73.0
HFD2_k127_883087_2 PFAM Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009338 460.0
HFD2_k127_883087_3 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 447.0
HFD2_k127_883087_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 433.0
HFD2_k127_883087_5 Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 375.0
HFD2_k127_883087_6 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 396.0
HFD2_k127_883087_7 TIGRFAM LAO AO transport system ATPase K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 345.0
HFD2_k127_883087_8 DNA polymerase alpha chain like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001283 256.0
HFD2_k127_883087_9 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000001053 241.0
HFD2_k127_918483_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 576.0
HFD2_k127_918483_1 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 512.0
HFD2_k127_918483_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 392.0
HFD2_k127_918483_3 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000718 275.0
HFD2_k127_918483_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000001726 160.0
HFD2_k127_918483_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000002783 59.0
HFD2_k127_936486_0 Large extracellular alpha-helical protein K06894 - - 0.0 2074.0
HFD2_k127_936486_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 9.464e-219 704.0
HFD2_k127_936486_10 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000001449 139.0
HFD2_k127_936486_11 - - - - 0.0000000000002434 72.0
HFD2_k127_936486_12 Putative regulatory protein - - - 0.00000000001245 66.0
HFD2_k127_936486_13 Extracellular repeat protein, HAF family - - - 0.00000001954 66.0
HFD2_k127_936486_2 SMART Elongator protein 3 MiaB NifB K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 553.0
HFD2_k127_936486_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007978 469.0
HFD2_k127_936486_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 419.0
HFD2_k127_936486_5 NAD(P)H-binding K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 308.0
HFD2_k127_936486_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 305.0
HFD2_k127_936486_7 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004338 276.0
HFD2_k127_936486_8 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000004818 252.0
HFD2_k127_936486_9 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000002264 192.0
HFD2_k127_961590_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 430.0
HFD2_k127_961590_1 PFAM Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000001022 204.0
HFD2_k127_961590_2 Thioesterase K18700 - 3.1.2.29 0.00000000000000000000000000000000000000000000000005674 182.0
HFD2_k127_961590_3 His Kinase A (phosphoacceptor) domain K10715 - 2.7.13.3 0.000000000000000000000000000000000003503 149.0
HFD2_k127_961590_4 radical SAM domain protein - - - 0.000000000000000000001284 110.0