Overview

ID MAG01634
Name HFD2_bin.21
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Eisenbacteria
Class RBG-16-71-46
Order RBG-16-71-46
Family RBG-16-71-46
Genus WS-11
Species
Assembly information
Completeness (%) 77.7
Contamination (%) 1.97
GC content (%) 73.0
N50 (bp) 43,366
Genome size (bp) 3,143,847

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2379

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1216337_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 1.75e-209 713.0
HFD2_k127_1216337_1 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000009369 222.0
HFD2_k127_1216337_2 Evidence 5 No homology to any previously reported sequences - - - 0.000000002142 59.0
HFD2_k127_1216337_3 Evidence 5 No homology to any previously reported sequences - - - 0.000003667 62.0
HFD2_k127_1263113_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 4.513e-254 802.0
HFD2_k127_1263113_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.178e-242 763.0
HFD2_k127_1263113_10 aconitate hydratase K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 319.0
HFD2_k127_1263113_11 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000161 303.0
HFD2_k127_1263113_12 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002232 290.0
HFD2_k127_1263113_13 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001567 262.0
HFD2_k127_1263113_14 phosphate acetyltransferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000005727 269.0
HFD2_k127_1263113_15 SMART Integrin alpha beta-propellor repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006068 283.0
HFD2_k127_1263113_16 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001208 274.0
HFD2_k127_1263113_17 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001027 256.0
HFD2_k127_1263113_18 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000691 236.0
HFD2_k127_1263113_19 DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000001659 203.0
HFD2_k127_1263113_2 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 529.0
HFD2_k127_1263113_20 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000003328 178.0
HFD2_k127_1263113_21 Phage integrase family - - - 0.000000000000000000000000000000000000000000004737 178.0
HFD2_k127_1263113_22 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000002112 171.0
HFD2_k127_1263113_23 Histidine kinase - - - 0.000000000000000000000000000000000000000312 170.0
HFD2_k127_1263113_24 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000007826 152.0
HFD2_k127_1263113_25 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000005032 138.0
HFD2_k127_1263113_26 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000001718 151.0
HFD2_k127_1263113_27 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000001954 138.0
HFD2_k127_1263113_28 - - - - 0.0000000000000000000000000000004989 140.0
HFD2_k127_1263113_29 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.000000000000000000000000000006022 137.0
HFD2_k127_1263113_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 453.0
HFD2_k127_1263113_30 tRNA (adenine(22)-N(1))-methyltransferase K06967 - 2.1.1.217 0.00000000000000000000000000005145 129.0
HFD2_k127_1263113_31 Histidine kinase K01768,K12132 - 2.7.11.1,4.6.1.1 0.0000000000000000000000000002719 118.0
HFD2_k127_1263113_32 peptidyl-tyrosine sulfation - - - 0.00000000000000000000001352 116.0
HFD2_k127_1263113_33 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.0000000000000000000002395 109.0
HFD2_k127_1263113_34 Putative regulatory protein - - - 0.000000000000000000001069 97.0
HFD2_k127_1263113_35 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000001561 109.0
HFD2_k127_1263113_36 RNA methyltransferase K09761 - 2.1.1.193 0.000000000000000000004146 102.0
HFD2_k127_1263113_37 PFAM Pilus assembly protein PilO K02664 - - 0.00000000000000001298 91.0
HFD2_k127_1263113_38 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002336 79.0
HFD2_k127_1263113_39 Fimbrial assembly protein (PilN) K02663 - - 0.000000000008312 78.0
HFD2_k127_1263113_4 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 404.0
HFD2_k127_1263113_40 Patatin phospholipase K07001 - - 0.00000000009175 74.0
HFD2_k127_1263113_41 - - - - 0.000000002187 66.0
HFD2_k127_1263113_42 Pfam:N_methyl_2 K02650 - - 0.000000004458 65.0
HFD2_k127_1263113_44 E-Z type HEAT repeats - - - 0.00000009533 64.0
HFD2_k127_1263113_45 Patatin-like phospholipase K07001 - - 0.00000009947 64.0
HFD2_k127_1263113_46 Colicin V production protein - - - 0.00003951 53.0
HFD2_k127_1263113_47 DNA integration - - - 0.0004679 46.0
HFD2_k127_1263113_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 391.0
HFD2_k127_1263113_6 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 GO:0000003,GO:0000160,GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007059,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0019954,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0023052,GO:0030436,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0034622,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042254,GO:0042255,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0043933,GO:0043934,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 367.0
HFD2_k127_1263113_7 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 374.0
HFD2_k127_1263113_8 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 320.0
HFD2_k127_1263113_9 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 345.0
HFD2_k127_1355567_0 Prokaryotic cytochrome b561 - - - 0.0 1158.0
HFD2_k127_1355567_1 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008835 542.0
HFD2_k127_1355567_10 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000002008 157.0
HFD2_k127_1355567_11 Part of a membrane complex involved in electron transport K03612 - - 0.00000000000000000000000000000004529 144.0
HFD2_k127_1355567_12 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169 - 1.2.7.1 0.000000000000000000000000000001714 140.0
HFD2_k127_1355567_13 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.00000000000000000000000271 120.0
HFD2_k127_1355567_14 5'-nucleotidase - - - 0.0000000000000007802 88.0
HFD2_k127_1355567_15 oxidoreductase, alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.000000001473 61.0
HFD2_k127_1355567_16 electron transfer activity K05337 - - 0.000007924 51.0
HFD2_k127_1355567_17 - - - - 0.0000259 53.0
HFD2_k127_1355567_18 Glycosyltransferase family 87 K13671 - - 0.00002907 57.0
HFD2_k127_1355567_19 4Fe-4S binding domain K02572 - - 0.0004865 51.0
HFD2_k127_1355567_2 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 451.0
HFD2_k127_1355567_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 370.0
HFD2_k127_1355567_4 Bacterial regulatory helix-turn-helix protein, lysR family K03717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009691 364.0
HFD2_k127_1355567_5 Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005304 349.0
HFD2_k127_1355567_6 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347,K03614 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 341.0
HFD2_k127_1355567_7 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009591 259.0
HFD2_k127_1355567_8 Belongs to the TPP enzyme family K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000001517 265.0
HFD2_k127_1355567_9 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000006973 244.0
HFD2_k127_1388990_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 595.0
HFD2_k127_1388990_1 helicase superfamily c-terminal domain K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 528.0
HFD2_k127_1388990_10 PFAM metal-dependent phosphohydrolase, HD sub domain K09163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001707 270.0
HFD2_k127_1388990_11 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001443 273.0
HFD2_k127_1388990_12 Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001041 267.0
HFD2_k127_1388990_13 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000001129 244.0
HFD2_k127_1388990_14 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000525 246.0
HFD2_k127_1388990_15 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000009594 223.0
HFD2_k127_1388990_16 endonuclease activity K07451 - - 0.00000000000000000000000000000000000000000000000001152 199.0
HFD2_k127_1388990_17 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000001012 192.0
HFD2_k127_1388990_18 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000000000000001511 150.0
HFD2_k127_1388990_19 ATPases associated with a variety of cellular activities K16785,K16786,K16787 - - 0.0000000000000000000000000000000000009929 158.0
HFD2_k127_1388990_2 Threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 356.0
HFD2_k127_1388990_20 Diguanylate cyclase - - - 0.0000000000000000000000000000002916 145.0
HFD2_k127_1388990_21 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000165 138.0
HFD2_k127_1388990_22 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530,K05788 - - 0.00000000000000000000000000004852 119.0
HFD2_k127_1388990_23 PFAM HAD-superfamily hydrolase, subfamily IB - - - 0.0000000000000000000000000008757 133.0
HFD2_k127_1388990_24 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000005529 114.0
HFD2_k127_1388990_25 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000938 121.0
HFD2_k127_1388990_26 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000004131 105.0
HFD2_k127_1388990_27 Tetratricopeptide repeat - - - 0.0000005826 63.0
HFD2_k127_1388990_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 317.0
HFD2_k127_1388990_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 323.0
HFD2_k127_1388990_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009716 309.0
HFD2_k127_1388990_6 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007664 317.0
HFD2_k127_1388990_7 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 290.0
HFD2_k127_1388990_8 Putative neutral zinc metallopeptidase K06973 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000669 284.0
HFD2_k127_1388990_9 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 282.0
HFD2_k127_1396572_0 PFAM ABC transporter related K06020 - 3.6.3.25 3.389e-253 792.0
HFD2_k127_1396572_1 Belongs to the MurCDEF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 599.0
HFD2_k127_1396572_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002149 260.0
HFD2_k127_1396572_11 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009684 257.0
HFD2_k127_1396572_12 Cupin domain K14977 - 3.5.3.26 0.000000000000000000000000000000000000000000000000000000000000002147 226.0
HFD2_k127_1396572_13 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000001384 228.0
HFD2_k127_1396572_14 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000006605 207.0
HFD2_k127_1396572_15 Belongs to the MurCDEF family - - - 0.000000000000000000000000000000000000000000000000000000124 216.0
HFD2_k127_1396572_16 membrane - - - 0.0000000000000000000000000000000000000000005544 166.0
HFD2_k127_1396572_17 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000007025 135.0
HFD2_k127_1396572_18 Pregnancy-associated plasma protein-A - - - 0.000000000000000000000000000001932 139.0
HFD2_k127_1396572_2 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 560.0
HFD2_k127_1396572_20 Protein of unknown function (DUF3175) - - - 0.0000000000000000000000000001035 127.0
HFD2_k127_1396572_21 SURF1 family K14998 - - 0.000000000000000000000000001008 122.0
HFD2_k127_1396572_22 endonuclease activity K07451 - - 0.000000000000000000000000001162 119.0
HFD2_k127_1396572_23 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.0000000000000000000000006103 106.0
HFD2_k127_1396572_24 - - - - 0.0000000000000000000006729 107.0
HFD2_k127_1396572_25 Laminin G domain - - - 0.00000000008888 75.0
HFD2_k127_1396572_26 - - - - 0.000005545 57.0
HFD2_k127_1396572_27 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00004989 52.0
HFD2_k127_1396572_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 549.0
HFD2_k127_1396572_4 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 542.0
HFD2_k127_1396572_5 6-phosphofructokinase activity K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 507.0
HFD2_k127_1396572_6 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 522.0
HFD2_k127_1396572_7 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 457.0
HFD2_k127_1396572_8 PFAM peptidase T2 asparaginase 2 K01444,K13051 - 3.4.19.5,3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 414.0
HFD2_k127_1396572_9 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003506 282.0
HFD2_k127_1420717_0 SMART Elongator protein 3 MiaB NifB - - - 2.27e-215 678.0
HFD2_k127_1420717_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 8.988e-206 682.0
HFD2_k127_1420717_10 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 401.0
HFD2_k127_1420717_11 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 400.0
HFD2_k127_1420717_12 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 416.0
HFD2_k127_1420717_13 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 366.0
HFD2_k127_1420717_14 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 368.0
HFD2_k127_1420717_15 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 363.0
HFD2_k127_1420717_16 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 364.0
HFD2_k127_1420717_17 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 314.0
HFD2_k127_1420717_18 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 298.0
HFD2_k127_1420717_19 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 312.0
HFD2_k127_1420717_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.273e-203 665.0
HFD2_k127_1420717_20 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001317 291.0
HFD2_k127_1420717_21 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000003024 234.0
HFD2_k127_1420717_22 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000001386 218.0
HFD2_k127_1420717_23 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000001217 214.0
HFD2_k127_1420717_24 Type II secretion system (T2SS), protein F K12511 - - 0.00000000000000000000000000000000000000000000000000000002996 209.0
HFD2_k127_1420717_25 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000003162 192.0
HFD2_k127_1420717_26 OsmC-like protein K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.000000000000000000000000000000000000000000001445 177.0
HFD2_k127_1420717_27 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000274 176.0
HFD2_k127_1420717_28 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000009529 183.0
HFD2_k127_1420717_29 Belongs to the GSP D family K02280 - - 0.00000000000000000000000000000000000000000001809 176.0
HFD2_k127_1420717_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 587.0
HFD2_k127_1420717_30 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000009308 163.0
HFD2_k127_1420717_31 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000006219 177.0
HFD2_k127_1420717_32 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000001784 160.0
HFD2_k127_1420717_33 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000001835 153.0
HFD2_k127_1420717_34 methyltransferase activity - - - 0.0000000000000000000000000000000000005639 148.0
HFD2_k127_1420717_35 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919,K16924 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000002302 155.0
HFD2_k127_1420717_36 SAF K02279 - - 0.00000000000000000000000000000000007923 145.0
HFD2_k127_1420717_37 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000007592 140.0
HFD2_k127_1420717_38 Cellulose biosynthesis protein BcsQ K02282 - - 0.0000000000000000000000000002013 130.0
HFD2_k127_1420717_39 Single-strand binding protein family K03111 - - 0.000000000000000000000000007067 115.0
HFD2_k127_1420717_4 Phosphoribosyl transferase domain K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 536.0
HFD2_k127_1420717_40 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000009668 116.0
HFD2_k127_1420717_41 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000001036 124.0
HFD2_k127_1420717_42 Cell Wall K01448 - 3.5.1.28 0.0000000000000000000000006075 122.0
HFD2_k127_1420717_43 Could be involved in septation K06412 - - 0.000000000000000000000001077 107.0
HFD2_k127_1420717_44 Glycogen recognition site of AMP-activated protein kinase - - - 0.000000000000000000000001873 111.0
HFD2_k127_1420717_45 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000002488 101.0
HFD2_k127_1420717_46 SnoaL-like domain - - - 0.000000000000000000005092 103.0
HFD2_k127_1420717_47 Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.0000000000000000002199 95.0
HFD2_k127_1420717_48 Aspartyl protease - - - 0.00000000000000001057 98.0
HFD2_k127_1420717_49 - - - - 0.0000000000000002807 91.0
HFD2_k127_1420717_5 type II secretion system protein E K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 509.0
HFD2_k127_1420717_50 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000009154 91.0
HFD2_k127_1420717_51 Modulates RecA activity K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000001683 86.0
HFD2_k127_1420717_52 - - - - 0.000000000002177 78.0
HFD2_k127_1420717_53 Magnesium chelatase, subunit ChlI K07391 - - 0.000000000002818 69.0
HFD2_k127_1420717_54 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000003012 75.0
HFD2_k127_1420717_55 Peptidylprolyl isomerase K01802,K03769 - 5.2.1.8 0.00000000004966 76.0
HFD2_k127_1420717_56 Archease protein family (MTH1598/TM1083) - - - 0.0000000005575 66.0
HFD2_k127_1420717_57 CAAX protease self-immunity K07052 - - 0.000000002371 68.0
HFD2_k127_1420717_58 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000001028 64.0
HFD2_k127_1420717_59 Pkd domain containing protein - - - 0.00000001782 66.0
HFD2_k127_1420717_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 482.0
HFD2_k127_1420717_60 Predicted membrane protein (DUF2232) - - - 0.00000002807 65.0
HFD2_k127_1420717_62 protein secretion - - - 0.00001258 59.0
HFD2_k127_1420717_63 protein trimerization - - - 0.00005466 56.0
HFD2_k127_1420717_64 Exodeoxyribonuclease III - - - 0.000107 56.0
HFD2_k127_1420717_65 TadE-like protein - - - 0.0001136 52.0
HFD2_k127_1420717_66 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0002086 51.0
HFD2_k127_1420717_67 transposase activity K07497 - - 0.0002199 50.0
HFD2_k127_1420717_7 Aldo/keto reductase family K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 481.0
HFD2_k127_1420717_8 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 450.0
HFD2_k127_1420717_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 428.0
HFD2_k127_1426485_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 546.0
HFD2_k127_1426485_1 FAD linked oxidase domain protein K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 445.0
HFD2_k127_1426485_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 308.0
HFD2_k127_1426485_3 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006331 261.0
HFD2_k127_1426485_4 cellulase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000004633 212.0
HFD2_k127_1426485_5 - - - - 0.000000000000000000000000000000000000000000000001389 181.0
HFD2_k127_1426485_6 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000002883 123.0
HFD2_k127_1426485_7 Esterase-like activity of phytase - - - 0.000001029 62.0
HFD2_k127_1426485_8 Cytochrome c - - - 0.00001312 55.0
HFD2_k127_1505505_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1338.0
HFD2_k127_1505505_1 Sortilin, neurotensin receptor 3, - - - 0.0 1276.0
HFD2_k127_1505505_10 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 389.0
HFD2_k127_1505505_11 imidazolonepropionase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 377.0
HFD2_k127_1505505_12 aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 381.0
HFD2_k127_1505505_13 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 302.0
HFD2_k127_1505505_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 299.0
HFD2_k127_1505505_15 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 289.0
HFD2_k127_1505505_16 conserved protein (COG2071) K09166 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009801 282.0
HFD2_k127_1505505_17 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008411 297.0
HFD2_k127_1505505_18 domain protein K13735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001125 281.0
HFD2_k127_1505505_19 enzyme related to lactoylglutathione lyase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003173 267.0
HFD2_k127_1505505_2 Bacterial protein of unknown function (DUF853) K06915 - - 1.287e-246 769.0
HFD2_k127_1505505_20 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000239 250.0
HFD2_k127_1505505_21 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000871 216.0
HFD2_k127_1505505_22 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000000000000000000000000000003347 201.0
HFD2_k127_1505505_23 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000002467 196.0
HFD2_k127_1505505_24 Domain of unknown function (DUF4956) - - - 0.000000000000000000000000000000000000000000000000000007538 208.0
HFD2_k127_1505505_25 pilus organization - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000002973 207.0
HFD2_k127_1505505_26 pilus organization - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000002555 192.0
HFD2_k127_1505505_27 VTC domain - - - 0.00000000000000000000000000000000000000000000000518 188.0
HFD2_k127_1505505_28 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000007506 191.0
HFD2_k127_1505505_29 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000001448 184.0
HFD2_k127_1505505_3 imidazolonepropionase activity K01443 - 3.5.1.25 1.147e-232 760.0
HFD2_k127_1505505_30 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000007918 172.0
HFD2_k127_1505505_31 - - - - 0.0000000000000000000000000000000000001671 148.0
HFD2_k127_1505505_32 - - - - 0.00000000000000000000000000000001015 131.0
HFD2_k127_1505505_33 PFAM Methyltransferase domain - - - 0.00000000000000000000000000000002315 136.0
HFD2_k127_1505505_34 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000005752 139.0
HFD2_k127_1505505_35 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000008296 124.0
HFD2_k127_1505505_37 Outer membrane efflux protein - - - 0.000000000000000000000001232 118.0
HFD2_k127_1505505_39 Purple acid Phosphatase, N-terminal domain - - - 0.0000000000000000000004222 114.0
HFD2_k127_1505505_4 peptidase K01415,K07386 - 3.4.24.71 4.727e-206 664.0
HFD2_k127_1505505_40 Putative zinc ribbon domain - - - 0.00000000000000000007515 91.0
HFD2_k127_1505505_41 - - - - 0.000000000000000004738 91.0
HFD2_k127_1505505_42 Thrombospondin type 3 repeat - - - 0.00000000003782 76.0
HFD2_k127_1505505_44 Cupredoxin-like domain - - - 0.000000003583 63.0
HFD2_k127_1505505_45 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000005133 63.0
HFD2_k127_1505505_46 Ferritin-like domain K03594 - 1.16.3.1 0.00000007905 63.0
HFD2_k127_1505505_47 - - - - 0.0000007783 59.0
HFD2_k127_1505505_48 Belongs to the ompA family - - - 0.000003737 59.0
HFD2_k127_1505505_49 calcium- and calmodulin-responsive adenylate cyclase activity K01179 - 3.2.1.4 0.00006883 56.0
HFD2_k127_1505505_5 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 3.585e-195 620.0
HFD2_k127_1505505_50 LVIVD repeat K01179 - 3.2.1.4 0.00007122 55.0
HFD2_k127_1505505_51 E1-E2 ATPase K17686 - 3.6.3.54 0.0002144 53.0
HFD2_k127_1505505_52 - - - - 0.0005182 53.0
HFD2_k127_1505505_6 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008321 627.0
HFD2_k127_1505505_7 pilus organization K02674,K07004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 611.0
HFD2_k127_1505505_8 metallocarboxypeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 450.0
HFD2_k127_1505505_9 Cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 414.0
HFD2_k127_1534037_0 Cytochrome C and Quinol oxidase polypeptide I - - - 7.916e-266 840.0
HFD2_k127_1534037_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.505e-252 814.0
HFD2_k127_1534037_10 cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000005293 159.0
HFD2_k127_1534037_11 3-beta hydroxysteroid dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000001146 162.0
HFD2_k127_1534037_12 PFAM Squalene phytoene synthase K00801 - 2.5.1.21 0.000000000000000000000000000000002812 150.0
HFD2_k127_1534037_13 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000007756 140.0
HFD2_k127_1534037_14 Oxidoreductase domain protein K18855 - 1.1.1.374 0.00000000000000000000000000000002352 145.0
HFD2_k127_1534037_15 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000006463 113.0
HFD2_k127_1534037_16 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000007406 100.0
HFD2_k127_1534037_18 E3 Ubiquitin ligase - - - 0.000000000000000343 88.0
HFD2_k127_1534037_19 Hsp20/alpha crystallin family - - - 0.000000000000003758 82.0
HFD2_k127_1534037_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008573 581.0
HFD2_k127_1534037_21 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000005275 76.0
HFD2_k127_1534037_22 - - - - 0.0000000003943 71.0
HFD2_k127_1534037_23 - - - - 0.0000000004574 61.0
HFD2_k127_1534037_24 - - - - 0.000000008923 69.0
HFD2_k127_1534037_25 - - - - 0.00000003728 67.0
HFD2_k127_1534037_26 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000008675 59.0
HFD2_k127_1534037_3 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 390.0
HFD2_k127_1534037_4 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009454 325.0
HFD2_k127_1534037_5 Cytochrome C oxidase subunit II, periplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003111 257.0
HFD2_k127_1534037_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000002725 261.0
HFD2_k127_1534037_7 Cytochrome c oxidase subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000007975 218.0
HFD2_k127_1534037_8 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000002494 183.0
HFD2_k127_1534037_9 Cytochrome c - - - 0.00000000000000000000000000000000000000000000002525 180.0
HFD2_k127_1600254_0 AMP-binding enzyme C-terminal domain - - - 1.545e-198 643.0
HFD2_k127_1600254_1 Beta-eliminating lyase K01667 - 4.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 609.0
HFD2_k127_1600254_10 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 352.0
HFD2_k127_1600254_11 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 311.0
HFD2_k127_1600254_12 Repeats in polycystic kidney disease 1 (PKD1) and other proteins K02674,K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 324.0
HFD2_k127_1600254_13 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001806 249.0
HFD2_k127_1600254_14 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000001959 234.0
HFD2_k127_1600254_15 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000007289 235.0
HFD2_k127_1600254_16 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000000000000000000000000000001735 205.0
HFD2_k127_1600254_17 3-hydroxyacyl-CoA dehydrogenase K00074 GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 1.1.1.157 0.0000000000000000000000000000000000000000000000001139 203.0
HFD2_k127_1600254_18 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000301 188.0
HFD2_k127_1600254_19 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000002164 162.0
HFD2_k127_1600254_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 492.0
HFD2_k127_1600254_20 PFAM PKD domain - - - 0.0000000000000000000000000000000007744 148.0
HFD2_k127_1600254_21 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000002296 128.0
HFD2_k127_1600254_22 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000004088 129.0
HFD2_k127_1600254_23 acetyltransferase - - - 0.00000000000000000000000000005978 131.0
HFD2_k127_1600254_24 acyl carrier protein - - - 0.00000000000000008528 96.0
HFD2_k127_1600254_25 peptidase activity, acting on L-amino acid peptides K01187,K01448,K07752 - 3.2.1.20,3.4.17.22,3.5.1.28 0.00000000007296 74.0
HFD2_k127_1600254_26 Hemerythrin HHE cation binding domain - - - 0.0000001478 62.0
HFD2_k127_1600254_27 Ami_3 K01448 - 3.5.1.28 0.0001729 53.0
HFD2_k127_1600254_28 - - - - 0.0001773 53.0
HFD2_k127_1600254_3 negative regulation of protein lipidation K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 510.0
HFD2_k127_1600254_4 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 460.0
HFD2_k127_1600254_5 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006848 451.0
HFD2_k127_1600254_6 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 463.0
HFD2_k127_1600254_7 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 422.0
HFD2_k127_1600254_8 Alanine dehydrogenase/PNT, C-terminal domain K07538 - 1.1.1.368 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 395.0
HFD2_k127_1600254_9 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 374.0
HFD2_k127_1601188_0 glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000004428 244.0
HFD2_k127_1601188_1 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000000008091 136.0
HFD2_k127_1601188_2 Acid phosphatase homologues - - - 0.000000000000000000008264 103.0
HFD2_k127_1601188_3 AAA domain - - - 0.00000000005243 77.0
HFD2_k127_1601188_5 COG4235 Cytochrome c biogenesis factor K02200 - - 0.00072 52.0
HFD2_k127_1786650_0 ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 501.0
HFD2_k127_1786650_1 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 365.0
HFD2_k127_1786650_10 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000003778 96.0
HFD2_k127_1786650_11 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000001143 63.0
HFD2_k127_1786650_12 Ribbon-helix-helix protein, copG family - - - 0.0007164 53.0
HFD2_k127_1786650_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 324.0
HFD2_k127_1786650_3 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002436 295.0
HFD2_k127_1786650_4 thymidine kinase activity K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000001482 238.0
HFD2_k127_1786650_5 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000001245 214.0
HFD2_k127_1786650_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000009549 200.0
HFD2_k127_1786650_7 Propeptide_C25 - - - 0.00000000000000000000000000000000000000000000001187 198.0
HFD2_k127_1786650_8 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000001291 142.0
HFD2_k127_1786650_9 Metallo-beta-lactamase superfamily - - - 0.00000000000000000001974 105.0
HFD2_k127_1858657_0 extracellular matrix structural constituent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 443.0
HFD2_k127_1858657_2 Serine hydrolase K07002 - - 0.00000000000000000000000000000000000000000000000000002034 192.0
HFD2_k127_1923923_0 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 391.0
HFD2_k127_1923923_1 PFAM ATP-binding region ATPase domain protein K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000006427 202.0
HFD2_k127_1970140_0 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000007817 161.0
HFD2_k127_1970140_1 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000002003 142.0
HFD2_k127_1970140_2 ArsR family transcriptional regulator - - - 0.0000000001394 66.0
HFD2_k127_1970140_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000003056 60.0
HFD2_k127_1970140_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00001652 57.0
HFD2_k127_2095746_0 MMPL family K03296 - - 0.0 1149.0
HFD2_k127_2095746_1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 7.291e-255 801.0
HFD2_k127_2095746_10 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 377.0
HFD2_k127_2095746_11 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 324.0
HFD2_k127_2095746_12 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 333.0
HFD2_k127_2095746_13 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 316.0
HFD2_k127_2095746_14 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005701 293.0
HFD2_k127_2095746_15 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007299 286.0
HFD2_k127_2095746_16 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001884 269.0
HFD2_k127_2095746_17 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000001146 255.0
HFD2_k127_2095746_18 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007393 259.0
HFD2_k127_2095746_19 Beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000004317 256.0
HFD2_k127_2095746_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 2.252e-194 642.0
HFD2_k127_2095746_20 Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000000000000000000000000000003723 229.0
HFD2_k127_2095746_21 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000104 242.0
HFD2_k127_2095746_22 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000003908 199.0
HFD2_k127_2095746_23 - - - - 0.000000000000000000000000000000000000000000000000000004983 198.0
HFD2_k127_2095746_24 Phosphoesterase family K21302 GO:0003674,GO:0003824,GO:0003993,GO:0004438,GO:0004805,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006139,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006742,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009109,GO:0009117,GO:0009166,GO:0009987,GO:0016310,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019203,GO:0019362,GO:0019364,GO:0019438,GO:0019439,GO:0019637,GO:0030258,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046486,GO:0046488,GO:0046496,GO:0046700,GO:0046834,GO:0046854,GO:0050189,GO:0050192,GO:0051186,GO:0051187,GO:0052744,GO:0052866,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072526,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.3.64 0.00000000000000000000000000000000000000000000000007014 200.0
HFD2_k127_2095746_26 Beta-galactosidase - - - 0.00000000000000000000000000000000000000001175 173.0
HFD2_k127_2095746_27 - - - - 0.0000000000000000000000000000000006754 141.0
HFD2_k127_2095746_28 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000008514 143.0
HFD2_k127_2095746_29 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000009697 106.0
HFD2_k127_2095746_3 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 580.0
HFD2_k127_2095746_30 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.00000000000007314 85.0
HFD2_k127_2095746_31 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000007528 81.0
HFD2_k127_2095746_32 BNR repeat-like domain - - - 0.0000000002695 74.0
HFD2_k127_2095746_33 - - - - 0.000000005768 70.0
HFD2_k127_2095746_34 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000239 64.0
HFD2_k127_2095746_35 cellulase activity - - - 0.000003244 60.0
HFD2_k127_2095746_36 FlgD Ig-like domain - - - 0.0001504 55.0
HFD2_k127_2095746_4 palmitoyl-(protein) hydrolase activity K06999,K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 520.0
HFD2_k127_2095746_5 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 488.0
HFD2_k127_2095746_6 Arginosuccinate synthase K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 486.0
HFD2_k127_2095746_7 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 397.0
HFD2_k127_2095746_8 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 381.0
HFD2_k127_2095746_9 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 380.0
HFD2_k127_219610_0 HAD-superfamily hydrolase, subfamily IA, variant 1 K07025 - - 0.00000000000000000000000000000001653 136.0
HFD2_k127_219610_1 - - - - 0.0000000000000000000000000000004692 143.0
HFD2_k127_219610_2 - - - - 0.0000000000000000000004074 114.0
HFD2_k127_219610_3 Transport and Golgi organisation 2 - - - 0.00000000000006001 82.0
HFD2_k127_219610_4 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K01083,K06131,K06915 - 3.1.3.8 0.0001474 54.0
HFD2_k127_227032_0 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 314.0
HFD2_k127_227032_1 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000001541 234.0
HFD2_k127_227032_2 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0000000000000000000000000000000000000001562 170.0
HFD2_k127_227032_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000001506 81.0
HFD2_k127_2299387_0 PFAM Peptidase S10, serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 586.0
HFD2_k127_2299387_1 Sortilin, neurotensin receptor 3, - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 502.0
HFD2_k127_2299387_10 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001847 287.0
HFD2_k127_2299387_11 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007887 254.0
HFD2_k127_2299387_12 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000001067 238.0
HFD2_k127_2299387_13 Phospholipid methyltransferase - - - 0.00000000000000000000000000002156 128.0
HFD2_k127_2299387_14 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000005361 117.0
HFD2_k127_2299387_15 Predicted integral membrane protein (DUF2269) - - - 0.00000000000000000000000005149 114.0
HFD2_k127_2299387_16 Roadblock/LC7 domain - - - 0.0000000000000000000000001393 112.0
HFD2_k127_2299387_17 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000006372 102.0
HFD2_k127_2299387_18 Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.000000000000000002881 94.0
HFD2_k127_2299387_19 Resolvase - - - 0.000002986 50.0
HFD2_k127_2299387_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 468.0
HFD2_k127_2299387_20 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0001663 48.0
HFD2_k127_2299387_3 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 454.0
HFD2_k127_2299387_4 Sortilin, neurotensin receptor 3, - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 467.0
HFD2_k127_2299387_5 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 349.0
HFD2_k127_2299387_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 347.0
HFD2_k127_2299387_7 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 323.0
HFD2_k127_2299387_8 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 307.0
HFD2_k127_2299387_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005846 275.0
HFD2_k127_2299391_0 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 430.0
HFD2_k127_2299391_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K00066 - 1.1.1.132,1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006596 429.0
HFD2_k127_2299391_10 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000008 102.0
HFD2_k127_2299391_11 HAD-hyrolase-like - - - 0.0000002687 64.0
HFD2_k127_2299391_2 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 404.0
HFD2_k127_2299391_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 377.0
HFD2_k127_2299391_4 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 323.0
HFD2_k127_2299391_5 Sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002801 244.0
HFD2_k127_2299391_6 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000001486 231.0
HFD2_k127_2299391_7 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000137 210.0
HFD2_k127_2299391_8 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000002143 166.0
HFD2_k127_2299391_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000004275 109.0
HFD2_k127_2431392_0 cellulose binding - - - 0.0 1324.0
HFD2_k127_2431392_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 624.0
HFD2_k127_2431392_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000004408 87.0
HFD2_k127_2529621_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 496.0
HFD2_k127_2529621_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 391.0
HFD2_k127_2529621_10 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000594 121.0
HFD2_k127_2529621_11 PFAM beta-lactamase domain protein - - - 0.00000000000000000006133 96.0
HFD2_k127_2529621_12 Periplasmic or secreted lipoprotein - - - 0.0000000000007158 80.0
HFD2_k127_2529621_13 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000009218 78.0
HFD2_k127_2529621_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 334.0
HFD2_k127_2529621_3 Sigma-54 interaction domain K02584,K07713,K15836,K21009 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004867 290.0
HFD2_k127_2529621_4 Cys/Met metabolism PLP-dependent enzyme K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000001675 269.0
HFD2_k127_2529621_5 cellulase activity - - - 0.0000000000000000000000000000000000000000000000000000005657 202.0
HFD2_k127_2529621_6 Belongs to the peptidase S11 family K01286,K07258,K07262 GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016043,GO:0016787,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0030203,GO:0032505,GO:0042221,GO:0042493,GO:0042597,GO:0043093,GO:0043170,GO:0044238,GO:0044464,GO:0045229,GO:0050896,GO:0051301,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564 3.4.16.4 0.00000000000000000000000000000000000000000000003209 184.0
HFD2_k127_2529621_7 NUDIX domain - - - 0.00000000000000000000000000000000000000000007643 167.0
HFD2_k127_2529621_8 membrane transporter protein K07090 - - 0.00000000000000000000000000000002038 138.0
HFD2_k127_2529621_9 oligosaccharyl transferase activity - - - 0.000000000000000000000000003427 129.0
HFD2_k127_2611832_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 564.0
HFD2_k127_2611832_1 BT1 family K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 544.0
HFD2_k127_2611832_10 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002409 271.0
HFD2_k127_2611832_11 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000001043 247.0
HFD2_k127_2611832_12 glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000002265 236.0
HFD2_k127_2611832_13 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000004422 236.0
HFD2_k127_2611832_14 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000002532 217.0
HFD2_k127_2611832_16 - - - - 0.0000000000000000000000000000000004461 138.0
HFD2_k127_2611832_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000007146 152.0
HFD2_k127_2611832_18 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000002598 128.0
HFD2_k127_2611832_19 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000000000000000004403 125.0
HFD2_k127_2611832_2 Nucleoside recognition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 512.0
HFD2_k127_2611832_20 Predicted membrane protein (DUF2079) - - - 0.0000000000000000000000002306 123.0
HFD2_k127_2611832_21 Protein of unknown function (DUF3303) - - - 0.000000000000000000001468 96.0
HFD2_k127_2611832_22 - - - - 0.000001836 59.0
HFD2_k127_2611832_23 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.000003607 60.0
HFD2_k127_2611832_24 - - - - 0.0000173 56.0
HFD2_k127_2611832_26 PFAM NHL repeat containing protein - - - 0.0001817 53.0
HFD2_k127_2611832_27 PFAM Anti-sigma-K factor RskA - - - 0.0008529 50.0
HFD2_k127_2611832_3 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 407.0
HFD2_k127_2611832_4 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 420.0
HFD2_k127_2611832_5 aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 372.0
HFD2_k127_2611832_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 340.0
HFD2_k127_2611832_7 galactose-1-phosphate K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 292.0
HFD2_k127_2611832_8 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006516 301.0
HFD2_k127_2611832_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008564 283.0
HFD2_k127_2638353_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 620.0
HFD2_k127_2638353_1 domain protein K02674,K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 550.0
HFD2_k127_2638353_10 iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000004088 196.0
HFD2_k127_2638353_11 undecaprenyl-phosphate glucose phosphotransferase activity K05946,K21303 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.187,2.7.8.40 0.0000000000000000000000000000000000000000000000000149 191.0
HFD2_k127_2638353_12 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000001654 193.0
HFD2_k127_2638353_13 hydrolase of the alpha beta K07018 - - 0.00000000000000000000000000000000000000000007748 176.0
HFD2_k127_2638353_14 manually curated - - - 0.00000000000000000000000000006222 121.0
HFD2_k127_2638353_15 Methyltransferase domain - - - 0.000000000000000000000000102 121.0
HFD2_k127_2638353_16 polysaccharide catabolic process K01179,K01218 - 3.2.1.4,3.2.1.78 0.000000000000000003036 96.0
HFD2_k127_2638353_17 PFAM Fibronectin, type III domain K01179,K06882 - 3.2.1.4 0.00000000000000006173 93.0
HFD2_k127_2638353_18 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000243 91.0
HFD2_k127_2638353_19 - - - - 0.000000000000003396 91.0
HFD2_k127_2638353_2 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 440.0
HFD2_k127_2638353_20 - - - - 0.000000000002148 79.0
HFD2_k127_2638353_21 long-chain fatty acid transporting porin activity - - - 0.000000007886 69.0
HFD2_k127_2638353_22 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0002422 53.0
HFD2_k127_2638353_3 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 383.0
HFD2_k127_2638353_4 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 381.0
HFD2_k127_2638353_5 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 351.0
HFD2_k127_2638353_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005006 286.0
HFD2_k127_2638353_7 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001022 259.0
HFD2_k127_2638353_8 Domain of unknown function (DUF3473) - - - 0.000000000000000000000000000000000000000000000000000000000000000009342 250.0
HFD2_k127_2638353_9 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000002208 235.0
HFD2_k127_2755191_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006637 503.0
HFD2_k127_2755191_1 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006095 417.0
HFD2_k127_2755191_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 338.0
HFD2_k127_2755191_3 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 325.0
HFD2_k127_2755191_4 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000000000000000000000000000000000000000253 207.0
HFD2_k127_2755191_5 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000004278 162.0
HFD2_k127_2755191_6 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000006816 120.0
HFD2_k127_2755191_7 oligosaccharyl transferase activity - - - 0.00000000000000000000000382 120.0
HFD2_k127_2755191_8 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000005028 64.0
HFD2_k127_279469_0 Helix-hairpin-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006386 269.0
HFD2_k127_279469_1 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02005 - - 0.000000002566 59.0
HFD2_k127_279469_2 universal stress protein - - - 0.0000008003 57.0
HFD2_k127_2869237_0 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002339 271.0
HFD2_k127_2869237_1 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000004121 205.0
HFD2_k127_2869237_2 CoA-binding domain protein - - - 0.0000000000000000000000009975 109.0
HFD2_k127_2869237_3 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.00000000000000001191 89.0
HFD2_k127_2908718_0 DnaB-like helicase C terminal domain K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000002765 201.0
HFD2_k127_2908718_1 Transcriptional regulator - - - 0.000000000000000000000000000000000001002 141.0
HFD2_k127_2908718_2 Glycosyl transferase, family 9 K02843 - - 0.000000000000000000000003576 106.0
HFD2_k127_2950771_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 1.206e-208 693.0
HFD2_k127_2950771_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.806e-195 651.0
HFD2_k127_2950771_10 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 321.0
HFD2_k127_2950771_11 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 307.0
HFD2_k127_2950771_12 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 313.0
HFD2_k127_2950771_13 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001368 271.0
HFD2_k127_2950771_14 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002666 275.0
HFD2_k127_2950771_15 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000001422 270.0
HFD2_k127_2950771_16 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000002327 247.0
HFD2_k127_2950771_17 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000555 245.0
HFD2_k127_2950771_18 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000001301 202.0
HFD2_k127_2950771_19 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000002616 190.0
HFD2_k127_2950771_2 Serine hydroxymethyltransferase K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 528.0
HFD2_k127_2950771_20 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000001823 187.0
HFD2_k127_2950771_21 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000001453 184.0
HFD2_k127_2950771_22 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000002004 171.0
HFD2_k127_2950771_23 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000003404 167.0
HFD2_k127_2950771_24 N-terminal domain of galactosyltransferase - - - 0.000000000000000000000000000000000000000000269 180.0
HFD2_k127_2950771_25 von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000000003415 179.0
HFD2_k127_2950771_26 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.0000000000000000000000000000000000000000323 166.0
HFD2_k127_2950771_27 Belongs to the SUA5 family K07566 GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000001096 162.0
HFD2_k127_2950771_28 Outer membrane protein assembly complex, YaeT protein K07277 - - 0.000000000000000000000000000000000001432 158.0
HFD2_k127_2950771_29 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000004921 136.0
HFD2_k127_2950771_3 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 524.0
HFD2_k127_2950771_30 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000001485 133.0
HFD2_k127_2950771_31 Oxygen tolerance - - - 0.000000000000000000000005737 120.0
HFD2_k127_2950771_32 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K20201 - 3.1.3.48,3.9.1.2 0.0000000000000000000002893 102.0
HFD2_k127_2950771_33 - - - - 0.0000000000003016 83.0
HFD2_k127_2950771_34 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000006978 73.0
HFD2_k127_2950771_35 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000008862 80.0
HFD2_k127_2950771_36 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000001324 68.0
HFD2_k127_2950771_37 - - - - 0.0001211 45.0
HFD2_k127_2950771_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 449.0
HFD2_k127_2950771_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 443.0
HFD2_k127_2950771_6 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 437.0
HFD2_k127_2950771_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 402.0
HFD2_k127_2950771_8 ATPase associated with various cellular K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 391.0
HFD2_k127_2950771_9 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 362.0
HFD2_k127_2958885_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1360.0
HFD2_k127_2958885_1 AAA domain - - - 0.0 1148.0
HFD2_k127_2958885_10 endonuclease activity K07451 - - 0.0000000000000000000000000008178 123.0
HFD2_k127_2958885_11 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.00005869 48.0
HFD2_k127_2958885_2 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 608.0
HFD2_k127_2958885_3 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 425.0
HFD2_k127_2958885_4 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 428.0
HFD2_k127_2958885_5 HlyD family secretion protein K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 335.0
HFD2_k127_2958885_6 Peptidase, S41 - - - 0.0000000000000000000000000000000000000000000000000000000000000002557 239.0
HFD2_k127_2958885_7 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000000004547 203.0
HFD2_k127_2958885_8 AcrB/AcrD/AcrF family K03296 - - 0.0000000000000000000000000000008614 140.0
HFD2_k127_2958885_9 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000003371 123.0
HFD2_k127_2960404_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.076e-220 709.0
HFD2_k127_2960404_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 565.0
HFD2_k127_2960404_10 Methyltransferase domain - - - 0.00000000000000000000000000000000003745 146.0
HFD2_k127_2960404_11 Belongs to the ComB family K05979 - 3.1.3.71 0.0000000000000000000000000000002247 132.0
HFD2_k127_2960404_12 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000001104 126.0
HFD2_k127_2960404_13 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000003003 119.0
HFD2_k127_2960404_14 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000001963 106.0
HFD2_k127_2960404_15 Protein of unknown function (DUF503) K09764 - - 0.00000000000000005085 85.0
HFD2_k127_2960404_16 WD40-like Beta Propeller Repeat - - - 0.000000002738 68.0
HFD2_k127_2960404_17 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00003343 56.0
HFD2_k127_2960404_2 Participates in both transcription termination and antitermination K02600 GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 432.0
HFD2_k127_2960404_3 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 317.0
HFD2_k127_2960404_4 Permease YjgP YjgQ family protein K07091,K11720 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 298.0
HFD2_k127_2960404_5 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000008404 244.0
HFD2_k127_2960404_6 Permease YjgP YjgQ K11720 - - 0.000000000000000000000000000000000000000000000000000000003294 226.0
HFD2_k127_2960404_7 Peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000001133 229.0
HFD2_k127_2960404_8 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000002097 201.0
HFD2_k127_2960404_9 PFAM Stage II sporulation protein E (SpoIIE) K07315 - 3.1.3.3 0.00000000000000000000000000000000000000006106 168.0
HFD2_k127_3010286_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1151.0
HFD2_k127_3010286_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 6.436e-225 726.0
HFD2_k127_3010286_2 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000002494 216.0
HFD2_k127_3010286_3 soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000001498 103.0
HFD2_k127_3010286_4 SMART Cold shock protein K03704 - - 0.0000000000000000001931 94.0
HFD2_k127_3010286_5 acyl-phosphate glycerol-3-phosphate acyltransferase activity K08591 - 2.3.1.15 0.00000000000000287 84.0
HFD2_k127_3010286_6 Tetratricopeptide repeats - - - 0.0000001345 66.0
HFD2_k127_3260480_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 1.864e-213 681.0
HFD2_k127_3260480_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 575.0
HFD2_k127_3260480_10 Transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 318.0
HFD2_k127_3260480_11 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002336 286.0
HFD2_k127_3260480_12 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003276 259.0
HFD2_k127_3260480_13 electron transfer activity K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000007791 254.0
HFD2_k127_3260480_14 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000001189 270.0
HFD2_k127_3260480_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000001351 248.0
HFD2_k127_3260480_16 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000003776 256.0
HFD2_k127_3260480_17 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000488 265.0
HFD2_k127_3260480_18 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000004685 222.0
HFD2_k127_3260480_19 MFS_1 like family - - - 0.000000000000000000000000000000000000000000000000000000000006993 225.0
HFD2_k127_3260480_2 ABC transporter transmembrane K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 577.0
HFD2_k127_3260480_20 - - - - 0.0000000000000000000000000000000000000000000000000000002159 207.0
HFD2_k127_3260480_21 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000006125 183.0
HFD2_k127_3260480_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000001247 178.0
HFD2_k127_3260480_23 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000297 171.0
HFD2_k127_3260480_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.000000000000000000000000000000000000000001726 158.0
HFD2_k127_3260480_25 Cupin domain - - - 0.0000000000000000000000000000000007857 138.0
HFD2_k127_3260480_26 C-terminal AAA-associated domain K02049 - - 0.000000000000000000000000000000001776 137.0
HFD2_k127_3260480_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000005758 130.0
HFD2_k127_3260480_28 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000005232 134.0
HFD2_k127_3260480_29 Tetratricopeptide repeat - - - 0.00000000000000000000000001329 129.0
HFD2_k127_3260480_3 ABC transporter K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 575.0
HFD2_k127_3260480_30 oligosaccharyl transferase activity - - - 0.0000000000000000000001224 114.0
HFD2_k127_3260480_31 MobA-like NTP transferase domain K03752 - 2.7.7.77 0.0000000001177 76.0
HFD2_k127_3260480_32 oligosaccharyl transferase activity - - - 0.0000000009222 73.0
HFD2_k127_3260480_4 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 527.0
HFD2_k127_3260480_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 501.0
HFD2_k127_3260480_6 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 458.0
HFD2_k127_3260480_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 437.0
HFD2_k127_3260480_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 389.0
HFD2_k127_3260480_9 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 376.0
HFD2_k127_348210_0 Nitrite and sulphite reductase 4Fe-4S domain K00366,K00392 - 1.7.7.1,1.8.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 497.0
HFD2_k127_348210_1 Formate nitrite - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 327.0
HFD2_k127_348210_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K01719,K01749,K02303,K13542,K13543 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.00000000000000000000000000000000000000000000000000003398 196.0
HFD2_k127_348210_3 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000947 156.0
HFD2_k127_3534323_0 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K12452,K13328 - 1.17.1.1,4.2.1.164 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 550.0
HFD2_k127_3534323_1 ADP-glyceromanno-heptose 6-epimerase activity K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 385.0
HFD2_k127_3534323_2 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 346.0
HFD2_k127_3534323_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002219 270.0
HFD2_k127_3534323_4 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000001121 230.0
HFD2_k127_3534323_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000004374 194.0
HFD2_k127_3534323_6 Tetratricopeptide repeat K11935 - - 0.0000000000000000000000000000000000007937 158.0
HFD2_k127_3534323_7 ECF sigma factor K03088 - - 0.000000000000000000000000000000003445 136.0
HFD2_k127_3534323_8 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000003128 137.0
HFD2_k127_3534323_9 AntiSigma factor - - - 0.00007197 55.0
HFD2_k127_3536569_0 Methionine synthase K00548 - 2.1.1.13 0.0 1282.0
HFD2_k127_3536569_10 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 478.0
HFD2_k127_3536569_11 amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 477.0
HFD2_k127_3536569_12 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 441.0
HFD2_k127_3536569_13 cellulose binding K00505 - 1.14.18.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 403.0
HFD2_k127_3536569_14 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006693 350.0
HFD2_k127_3536569_15 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K01501 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 350.0
HFD2_k127_3536569_16 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 344.0
HFD2_k127_3536569_17 PFAM metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 308.0
HFD2_k127_3536569_18 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 287.0
HFD2_k127_3536569_19 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002223 292.0
HFD2_k127_3536569_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1098.0
HFD2_k127_3536569_20 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006494 282.0
HFD2_k127_3536569_21 - - - - 0.00000000000000000000000000000000000000000000000000000000000005735 228.0
HFD2_k127_3536569_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000004547 228.0
HFD2_k127_3536569_23 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000001468 221.0
HFD2_k127_3536569_24 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000001465 209.0
HFD2_k127_3536569_25 - - - - 0.000000000000000000000000000000000000000000000000003522 204.0
HFD2_k127_3536569_26 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000008569 206.0
HFD2_k127_3536569_27 endonuclease activity K07451 - - 0.0000000000000000000000000000000000000000000001182 183.0
HFD2_k127_3536569_28 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000001776 152.0
HFD2_k127_3536569_29 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000002994 144.0
HFD2_k127_3536569_3 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1070.0
HFD2_k127_3536569_30 - - - - 0.000000000000001973 86.0
HFD2_k127_3536569_31 Endonuclease I K07004 - - 0.00000000002016 77.0
HFD2_k127_3536569_32 Phosphohistidine phosphatase, SixA K08296 - - 0.00000004023 61.0
HFD2_k127_3536569_33 endonuclease activity K07451 - - 0.0003485 46.0
HFD2_k127_3536569_4 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 0.0 1037.0
HFD2_k127_3536569_5 Glycosyl hydrolase 36 superfamily, catalytic domain - - - 1.208e-320 1047.0
HFD2_k127_3536569_6 TonB-dependent receptor - - - 3.088e-230 743.0
HFD2_k127_3536569_7 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 1.063e-206 657.0
HFD2_k127_3536569_8 Dienelactone hydrolase family - - - 8.674e-203 664.0
HFD2_k127_3536569_9 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 614.0
HFD2_k127_3588136_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.024e-194 638.0
HFD2_k127_3588136_1 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 496.0
HFD2_k127_3588136_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000009649 132.0
HFD2_k127_3588136_11 Domain of unknown function (DUF4160) - - - 0.00000000000000000000000000001474 125.0
HFD2_k127_3588136_12 Protein tyrosine kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000000000313 108.0
HFD2_k127_3588136_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000003131 110.0
HFD2_k127_3588136_14 Protein of unknown function (DUF2442) - - - 0.000000000000000000005131 94.0
HFD2_k127_3588136_15 Biotin-lipoyl like K01960,K01965,K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1,6.4.1.3,6.4.1.4 0.00000000000000002314 97.0
HFD2_k127_3588136_16 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000004982 82.0
HFD2_k127_3588136_18 PFAM Uncharacterised protein domain Spy-rel - - - 0.00007049 53.0
HFD2_k127_3588136_19 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006725,GO:0006732,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.0008741 42.0
HFD2_k127_3588136_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009414 451.0
HFD2_k127_3588136_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 383.0
HFD2_k127_3588136_4 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 363.0
HFD2_k127_3588136_5 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002858 247.0
HFD2_k127_3588136_6 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000002252 233.0
HFD2_k127_3588136_7 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000008175 212.0
HFD2_k127_3588136_8 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000001829 184.0
HFD2_k127_3588136_9 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000259 141.0
HFD2_k127_3613534_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000004094 164.0
HFD2_k127_3613534_1 CoA-binding protein K06929 - - 0.000000000000000000000000000000008898 141.0
HFD2_k127_3613534_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000001677 138.0
HFD2_k127_3613534_3 6-pyruvoyl tetrahydrobiopterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000001354 54.0
HFD2_k127_3621221_0 Peptidase family M41 K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0 1059.0
HFD2_k127_3621221_1 DEAD DEAH box helicase K06877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004516 611.0
HFD2_k127_3621221_10 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000003549 190.0
HFD2_k127_3621221_11 Uncharacterized ACR, COG1993 K06199,K09137 - - 0.000000000000000000000000000000000000000000000000001679 187.0
HFD2_k127_3621221_12 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000005448 199.0
HFD2_k127_3621221_13 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000008918 188.0
HFD2_k127_3621221_14 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000001342 191.0
HFD2_k127_3621221_15 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000001484 147.0
HFD2_k127_3621221_16 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000001331 125.0
HFD2_k127_3621221_17 DinB superfamily - - - 0.0000000000000000000000002217 111.0
HFD2_k127_3621221_18 Cold-shock protein - - - 0.00000000000000000000003599 108.0
HFD2_k127_3621221_19 Regulator of microtubule dynamics protein 3 - GO:0000922,GO:0005575,GO:0005622,GO:0005623,GO:0005819,GO:0005856,GO:0005874,GO:0005876,GO:0015630,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464,GO:0072686,GO:0097431,GO:0099080,GO:0099081,GO:0099512,GO:0099513 - 0.0000000000001878 80.0
HFD2_k127_3621221_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 507.0
HFD2_k127_3621221_20 PFAM Protein kinase - - - 0.00000000002601 76.0
HFD2_k127_3621221_3 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009189 492.0
HFD2_k127_3621221_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 425.0
HFD2_k127_3621221_5 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003554 411.0
HFD2_k127_3621221_6 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 316.0
HFD2_k127_3621221_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002637 280.0
HFD2_k127_3621221_8 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003209 281.0
HFD2_k127_3621221_9 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000008752 228.0
HFD2_k127_3655938_0 transcriptional regulator K07734 - - 0.00000000000000000000000000000000000000000000000000000002486 203.0
HFD2_k127_3655938_1 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000003189 182.0
HFD2_k127_3655938_2 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000001148 119.0
HFD2_k127_3655938_3 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000003311 83.0
HFD2_k127_379967_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 1.241e-217 703.0
HFD2_k127_379967_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 498.0
HFD2_k127_379967_10 endonuclease activity K07451 - - 0.00003435 52.0
HFD2_k127_379967_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006962 398.0
HFD2_k127_379967_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 337.0
HFD2_k127_379967_4 Belongs to the folylpolyglutamate synthase family K11754 GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000001979 229.0
HFD2_k127_379967_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000203 128.0
HFD2_k127_379967_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000004227 115.0
HFD2_k127_379967_7 - K02275,K17686 - 1.9.3.1,3.6.3.54 0.00000000000000000000000695 119.0
HFD2_k127_379967_8 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000001499 89.0
HFD2_k127_3848714_0 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 312.0
HFD2_k127_3848714_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 302.0
HFD2_k127_3848714_10 DUF167 K09131 - - 0.00000000000000002337 90.0
HFD2_k127_3848714_11 YGGT family K02221 - - 0.00000000000000004066 93.0
HFD2_k127_3848714_12 Transcriptional regulator antitoxin, MazE K07172 - - 0.0000000000003992 72.0
HFD2_k127_3848714_13 PFAM ATP-binding region, ATPase domain protein K04757 - 2.7.11.1 0.0000000000005127 77.0
HFD2_k127_3848714_2 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002928 254.0
HFD2_k127_3848714_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000002158 226.0
HFD2_k127_3848714_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000001257 192.0
HFD2_k127_3848714_5 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000001361 177.0
HFD2_k127_3848714_6 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.000000000000000000000000000000000000111 151.0
HFD2_k127_3848714_7 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000008297 140.0
HFD2_k127_3848714_8 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000005379 113.0
HFD2_k127_3848714_9 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000006917 102.0
HFD2_k127_3960938_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 328.0
HFD2_k127_3960938_1 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000008872 247.0
HFD2_k127_3960938_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08256 - 2.4.1.345,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000004635 247.0
HFD2_k127_3960938_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000002465 206.0
HFD2_k127_3960938_4 Diacylglycerol kinase catalytic domain (presumed) K07029 - 2.7.1.107 0.0000000000000000000000000000000000000000000001707 178.0
HFD2_k127_3960938_5 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.000000000000000000000000000000006361 149.0
HFD2_k127_3960938_6 Lipid A biosynthesis K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.0000000000000000000000000001008 127.0
HFD2_k127_3960938_7 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563,K13626 - - 0.000000000000001809 79.0
HFD2_k127_3960938_8 - - - - 0.0001275 51.0
HFD2_k127_3997785_0 Peptidase M3A and M3B thimet oligopeptidase F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 506.0
HFD2_k127_3997785_1 PFAM Peptidase M29, aminopeptidase II K19689 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 476.0
HFD2_k127_3997785_10 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000001818 227.0
HFD2_k127_3997785_11 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000001142 212.0
HFD2_k127_3997785_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000004859 178.0
HFD2_k127_3997785_13 Histidine kinase K14986 - 2.7.13.3 0.0000000000000000000000000000000000000003769 171.0
HFD2_k127_3997785_14 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000000000000000000000006031 137.0
HFD2_k127_3997785_16 - - - - 0.000000000000000000000000001709 117.0
HFD2_k127_3997785_17 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000002039 127.0
HFD2_k127_3997785_18 Glycosyl hydrolases family 32 N-terminal domain - - - 0.000000000000000000000005929 118.0
HFD2_k127_3997785_19 Tetratricopeptide repeat - - - 0.000000000000000000001716 100.0
HFD2_k127_3997785_2 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 434.0
HFD2_k127_3997785_20 - - - - 0.000000000000000000003011 99.0
HFD2_k127_3997785_21 Exopolysaccharide biosynthesis protein YbjH - - - 0.000000000000336 83.0
HFD2_k127_3997785_22 Papain-like cysteine protease AvrRpt2 - - - 0.0000000000006282 77.0
HFD2_k127_3997785_23 - - - - 0.00000000009055 70.0
HFD2_k127_3997785_24 nucleotide catabolic process K05996 - 3.4.17.18 0.0001428 55.0
HFD2_k127_3997785_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 383.0
HFD2_k127_3997785_4 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 366.0
HFD2_k127_3997785_5 PFAM Band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 336.0
HFD2_k127_3997785_6 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006546 339.0
HFD2_k127_3997785_7 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 293.0
HFD2_k127_3997785_8 PFAM Mandelate racemase muconate lactonizing protein K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000002417 258.0
HFD2_k127_3997785_9 BMC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005565 243.0
HFD2_k127_4417046_0 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 432.0
HFD2_k127_4417046_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000002277 104.0
HFD2_k127_4469546_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 475.0
HFD2_k127_4469546_1 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 475.0
HFD2_k127_4469546_10 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000000000009556 232.0
HFD2_k127_4469546_11 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000088 203.0
HFD2_k127_4469546_12 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000001305 185.0
HFD2_k127_4469546_13 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000005976 201.0
HFD2_k127_4469546_14 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000002231 171.0
HFD2_k127_4469546_15 MlaD protein K02067 - - 0.0000000000000000000000000000000000000007961 159.0
HFD2_k127_4469546_17 Protein of unknown function (DUF3224) - - - 0.0000000000000000000000000000006786 126.0
HFD2_k127_4469546_18 Fibronectin-binding protein A N-terminus (FbpA) K01153,K15524 - 3.1.21.3,3.2.1.170 0.000000000000000000000000015 125.0
HFD2_k127_4469546_2 Elongation factor Tu domain 2 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 461.0
HFD2_k127_4469546_20 - - - - 0.00000000000004119 85.0
HFD2_k127_4469546_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 452.0
HFD2_k127_4469546_4 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 336.0
HFD2_k127_4469546_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 326.0
HFD2_k127_4469546_6 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 318.0
HFD2_k127_4469546_7 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004392 277.0
HFD2_k127_4469546_8 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005833 248.0
HFD2_k127_4469546_9 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004378 236.0
HFD2_k127_4491077_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 611.0
HFD2_k127_4491077_1 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005593 280.0
HFD2_k127_4491077_2 Phosphodiester glycosidase - - - 0.00000000000000000000000000000000000000000000000002383 191.0
HFD2_k127_4491077_3 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000005188 194.0
HFD2_k127_4491077_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000001396 196.0
HFD2_k127_4491077_5 Cytochrome c - - - 0.00000000000000000000000000000000000000004053 159.0
HFD2_k127_4491077_6 B3/4 domain - - - 0.000000000000000000000000000000000136 147.0
HFD2_k127_4491077_7 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000006608 106.0
HFD2_k127_4491077_9 YacP-like NYN domain K06962 - - 0.00004157 53.0
HFD2_k127_4545866_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 8.075e-200 636.0
HFD2_k127_4545866_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 629.0
HFD2_k127_4545866_10 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000008497 224.0
HFD2_k127_4545866_11 trisaccharide binding K03556 - - 0.000000000000000000000000000000000000000000000000000001773 220.0
HFD2_k127_4545866_12 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000004166 205.0
HFD2_k127_4545866_13 Transmembrane protein 260 - - - 0.000000000000000000000000000000000000000000000003915 200.0
HFD2_k127_4545866_14 Lysophospholipase - GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704 - 0.000000000000000000000000000000000000000000004888 174.0
HFD2_k127_4545866_15 - - - - 0.000000000000000000000000000000000000000000004899 188.0
HFD2_k127_4545866_16 YceI-like domain - - - 0.0000000000000000000000000000000000001299 154.0
HFD2_k127_4545866_17 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000003344 139.0
HFD2_k127_4545866_18 Predicted membrane protein (DUF2079) - - - 0.00000000000000000000000000008676 135.0
HFD2_k127_4545866_19 - - - - 0.0000000000000000000000418 106.0
HFD2_k127_4545866_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 560.0
HFD2_k127_4545866_21 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000009424 98.0
HFD2_k127_4545866_22 ThiS family K03636 - - 0.0000000000003304 76.0
HFD2_k127_4545866_23 Belongs to the glycosyl hydrolase 31 family - - - 0.0000000000004802 83.0
HFD2_k127_4545866_25 Tetratricopeptide repeat - - - 0.000000000002483 76.0
HFD2_k127_4545866_26 Bacterial transcriptional activator domain - - - 0.000000000009511 79.0
HFD2_k127_4545866_27 LysM domain - - - 0.000002665 55.0
HFD2_k127_4545866_28 SPTR Peptidase S8 and S53 subtilisin kexin sedolisin K01113,K14645,K17713 - 3.1.3.1 0.000007347 60.0
HFD2_k127_4545866_29 cellulose binding K00505 - 1.14.18.1 0.00003416 55.0
HFD2_k127_4545866_3 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008956 555.0
HFD2_k127_4545866_30 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.0002316 45.0
HFD2_k127_4545866_4 DNA polymerase beta thumb K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 540.0
HFD2_k127_4545866_5 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 479.0
HFD2_k127_4545866_6 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000751 453.0
HFD2_k127_4545866_7 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 384.0
HFD2_k127_4545866_8 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000008625 234.0
HFD2_k127_4545866_9 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000003414 214.0
HFD2_k127_4567624_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 1.997e-271 845.0
HFD2_k127_4567624_1 electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 8.255e-203 645.0
HFD2_k127_4567624_10 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 447.0
HFD2_k127_4567624_100 DSBA-like thioredoxin domain - - - 0.0002569 51.0
HFD2_k127_4567624_11 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 415.0
HFD2_k127_4567624_12 PFAM Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 422.0
HFD2_k127_4567624_13 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 407.0
HFD2_k127_4567624_14 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 387.0
HFD2_k127_4567624_15 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 375.0
HFD2_k127_4567624_16 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 378.0
HFD2_k127_4567624_17 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 377.0
HFD2_k127_4567624_18 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 386.0
HFD2_k127_4567624_19 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 368.0
HFD2_k127_4567624_2 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 608.0
HFD2_k127_4567624_20 Arginase family K01476 - 3.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 359.0
HFD2_k127_4567624_21 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004078 374.0
HFD2_k127_4567624_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 364.0
HFD2_k127_4567624_23 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007991 345.0
HFD2_k127_4567624_24 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 357.0
HFD2_k127_4567624_25 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 342.0
HFD2_k127_4567624_26 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 347.0
HFD2_k127_4567624_27 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 337.0
HFD2_k127_4567624_28 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 317.0
HFD2_k127_4567624_29 Peptidase S9, prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 317.0
HFD2_k127_4567624_3 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 594.0
HFD2_k127_4567624_30 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 297.0
HFD2_k127_4567624_31 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 302.0
HFD2_k127_4567624_32 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001041 286.0
HFD2_k127_4567624_33 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001266 311.0
HFD2_k127_4567624_34 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008426 262.0
HFD2_k127_4567624_35 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000112 268.0
HFD2_k127_4567624_36 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000119 279.0
HFD2_k127_4567624_37 Transmembrane region of lysyl-tRNA synthetase K07027,K14205 - 2.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000003544 262.0
HFD2_k127_4567624_38 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000959 249.0
HFD2_k127_4567624_39 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000002272 245.0
HFD2_k127_4567624_4 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 592.0
HFD2_k127_4567624_40 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000001951 243.0
HFD2_k127_4567624_41 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000001323 227.0
HFD2_k127_4567624_42 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000001438 244.0
HFD2_k127_4567624_43 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000004277 225.0
HFD2_k127_4567624_44 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000002837 233.0
HFD2_k127_4567624_45 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000005419 229.0
HFD2_k127_4567624_46 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000758 233.0
HFD2_k127_4567624_47 metalloendopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000004813 223.0
HFD2_k127_4567624_48 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000005003 201.0
HFD2_k127_4567624_49 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000005504 206.0
HFD2_k127_4567624_5 DNA polymerase K02337,K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 560.0
HFD2_k127_4567624_50 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000000000002909 198.0
HFD2_k127_4567624_51 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000000001686 197.0
HFD2_k127_4567624_52 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.00000000000000000000000000000000000000000000000000000468 201.0
HFD2_k127_4567624_53 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000001603 200.0
HFD2_k127_4567624_54 - - - - 0.00000000000000000000000000000000000000000000000005379 183.0
HFD2_k127_4567624_55 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000006621 199.0
HFD2_k127_4567624_56 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000004954 175.0
HFD2_k127_4567624_57 BioY family K03523 - - 0.000000000000000000000000000000000000000000000006465 179.0
HFD2_k127_4567624_58 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000002513 186.0
HFD2_k127_4567624_59 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000001968 158.0
HFD2_k127_4567624_6 glucose-6-phosphate dehydrogenase activity K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000915 535.0
HFD2_k127_4567624_60 DinB family - - - 0.00000000000000000000000000000000000000005717 157.0
HFD2_k127_4567624_62 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000003779 141.0
HFD2_k127_4567624_63 PFAM Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000009811 158.0
HFD2_k127_4567624_64 nuclease activity - - - 0.000000000000000000000000000000000008466 142.0
HFD2_k127_4567624_65 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000002057 134.0
HFD2_k127_4567624_66 Molybdopterin converting factor, large subunit K03635 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.0000000000000000000000000000000003321 139.0
HFD2_k127_4567624_67 cell septum assembly - - - 0.000000000000000000000000000001612 135.0
HFD2_k127_4567624_68 Cold shock protein K03704 - - 0.00000000000000000000000000001494 118.0
HFD2_k127_4567624_69 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000005038 132.0
HFD2_k127_4567624_7 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 520.0
HFD2_k127_4567624_70 transcription factor binding K02584 - - 0.0000000000000000000000001564 115.0
HFD2_k127_4567624_71 - - - - 0.0000000000000000000000003362 121.0
HFD2_k127_4567624_72 Belongs to the ferrochelatase family K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000001955 121.0
HFD2_k127_4567624_73 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000615 110.0
HFD2_k127_4567624_74 CAAX protease self-immunity K07052 - - 0.00000000000000000000002369 113.0
HFD2_k127_4567624_75 PrcB C-terminal - - - 0.00000000000000000000005482 104.0
HFD2_k127_4567624_76 DoxX K15977 - - 0.000000000000000000000339 113.0
HFD2_k127_4567624_77 PA26 p53-induced protein (sestrin) - - - 0.0000000000000000000007896 102.0
HFD2_k127_4567624_78 Alpha beta hydrolase fold - - - 0.000000000000000000003182 104.0
HFD2_k127_4567624_79 positive regulation of growth - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000000000000003146 91.0
HFD2_k127_4567624_8 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 488.0
HFD2_k127_4567624_80 HEAT repeats - - - 0.000000000000000001029 101.0
HFD2_k127_4567624_81 - - - - 0.0000000000000001301 80.0
HFD2_k127_4567624_82 Catalytic LigB subunit of aromatic ring-opening dioxygenase K00455 - 1.13.11.15 0.0000000000000002993 93.0
HFD2_k127_4567624_83 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.000000000000002458 89.0
HFD2_k127_4567624_84 phosphate-selective porin O and P - - - 0.000000000000005018 88.0
HFD2_k127_4567624_85 repeat-containing protein - - - 0.0000000000001374 83.0
HFD2_k127_4567624_87 Helix-hairpin-helix motif - - - 0.0000000000004035 77.0
HFD2_k127_4567624_88 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000005465 79.0
HFD2_k127_4567624_89 STAS domain K04749 - - 0.000000000003966 71.0
HFD2_k127_4567624_9 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 473.0
HFD2_k127_4567624_90 - - - - 0.000000000007628 72.0
HFD2_k127_4567624_91 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000008291 74.0
HFD2_k127_4567624_92 GAF domain - - - 0.00000000112 68.0
HFD2_k127_4567624_93 - - - - 0.000000003498 68.0
HFD2_k127_4567624_94 Protein of unknown function, DUF255 - - - 0.00000001063 63.0
HFD2_k127_4567624_95 mannose-ethanolamine phosphotransferase activity - - - 0.00000003386 68.0
HFD2_k127_4567624_96 lactoylglutathione lyase activity K00941,K01724,K01759,K07032,K08234 - 2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5 0.0000001327 63.0
HFD2_k127_4567624_97 Belongs to the glycosyl hydrolase 13 family - - - 0.0000004662 57.0
HFD2_k127_4567624_98 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00001771 57.0
HFD2_k127_4567624_99 - - - - 0.00007336 56.0
HFD2_k127_4596142_0 M6 family metalloprotease domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 599.0
HFD2_k127_4596142_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 316.0
HFD2_k127_4596142_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 305.0
HFD2_k127_4596142_3 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000001516 247.0
HFD2_k127_4596142_4 regulation of translation K03530 - - 0.00000000000000000000000000002927 119.0
HFD2_k127_4596142_5 endonuclease activity K07451 - - 0.00000000000000000000001755 107.0
HFD2_k127_4596142_6 COG2199 FOG GGDEF domain - - - 0.000000000000000001754 102.0
HFD2_k127_4596142_7 - - - - 0.000000000000001047 91.0
HFD2_k127_4717484_0 iron-nicotianamine transmembrane transporter activity - - - 7e-322 1002.0
HFD2_k127_4717484_1 Ser Thr phosphatase family protein - - - 5.372e-297 976.0
HFD2_k127_4717484_10 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 367.0
HFD2_k127_4717484_11 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 375.0
HFD2_k127_4717484_12 symporter activity K03307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 348.0
HFD2_k127_4717484_13 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 334.0
HFD2_k127_4717484_14 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 322.0
HFD2_k127_4717484_15 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 316.0
HFD2_k127_4717484_16 A G-specific adenine glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 296.0
HFD2_k127_4717484_17 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001187 289.0
HFD2_k127_4717484_18 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006828 297.0
HFD2_k127_4717484_19 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000209 272.0
HFD2_k127_4717484_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01535,K01537 - 3.6.3.6,3.6.3.8 5.07e-245 787.0
HFD2_k127_4717484_20 Protein of unknown function (DUF3798) - - - 0.00000000000000000000000000000000000000000000000000000000002997 220.0
HFD2_k127_4717484_21 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000006172 207.0
HFD2_k127_4717484_22 COGs COG2912 conserved - - - 0.00000000000000000000000000000000000000000000000000000006166 207.0
HFD2_k127_4717484_23 domain protein K01179,K02238,K20276 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000007658 216.0
HFD2_k127_4717484_24 - - - - 0.000000000000000000000000000000000000000000000005734 196.0
HFD2_k127_4717484_25 PFAM secretion protein HlyD family protein K01993 - - 0.00000000000000000000000000000000000000000000003892 197.0
HFD2_k127_4717484_26 Rhomboid family - - - 0.000000000000000000000000000000000000000000003948 187.0
HFD2_k127_4717484_27 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000008895 147.0
HFD2_k127_4717484_28 peptidase activity - - - 0.0000000000000000000000000000000000118 153.0
HFD2_k127_4717484_29 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000135 153.0
HFD2_k127_4717484_3 cystathionine gamma-synthase activity K01739,K01740,K01760,K01761 - 2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8 1.132e-194 617.0
HFD2_k127_4717484_30 Belongs to the glutamate synthase family K00284 - 1.4.7.1 0.00000000000000000000000000000984 141.0
HFD2_k127_4717484_31 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000004034 124.0
HFD2_k127_4717484_32 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000009848 124.0
HFD2_k127_4717484_33 positive regulation of type IV pilus biogenesis K07343 - - 0.00000000000000000000000182 119.0
HFD2_k127_4717484_34 Phosphate acyltransferases - - - 0.0000000000000000001467 105.0
HFD2_k127_4717484_35 Acetyltransferase (GNAT) domain - - - 0.000000000000000001517 97.0
HFD2_k127_4717484_36 FAD linked oxidase domain protein - - - 0.000000000000438 83.0
HFD2_k127_4717484_37 Transposase, Mutator family - - - 0.00000000003078 64.0
HFD2_k127_4717484_38 Evidence 5 No homology to any previously reported sequences - - - 0.00000008575 64.0
HFD2_k127_4717484_39 Belongs to the peptidase S8 family - - - 0.000001129 63.0
HFD2_k127_4717484_4 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 572.0
HFD2_k127_4717484_40 Fibronectin type 3 domain - - - 0.000001253 63.0
HFD2_k127_4717484_41 cellulase activity - - - 0.000001576 61.0
HFD2_k127_4717484_42 4Fe-4S dicluster domain K11473 - - 0.000002963 61.0
HFD2_k127_4717484_43 Concanavalin A-like lectin/glucanases superfamily - - - 0.00001952 59.0
HFD2_k127_4717484_44 SMART Tetratricopeptide domain protein - - - 0.0006809 53.0
HFD2_k127_4717484_45 4Fe-4S dicluster domain - - - 0.0009693 53.0
HFD2_k127_4717484_5 oligopeptide transport K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 536.0
HFD2_k127_4717484_6 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 524.0
HFD2_k127_4717484_7 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 460.0
HFD2_k127_4717484_8 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 411.0
HFD2_k127_4717484_9 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 380.0
HFD2_k127_4720291_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 399.0
HFD2_k127_4720291_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000002492 214.0
HFD2_k127_4720291_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000002244 158.0
HFD2_k127_4774234_0 ERAP1-like C-terminal domain K01256,K01263 - 3.4.11.14,3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 572.0
HFD2_k127_4774234_1 PFAM aminotransferase, class I K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 529.0
HFD2_k127_4774234_10 Cys/Met metabolism PLP-dependent enzyme K01758,K01760 - 4.4.1.1,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 309.0
HFD2_k127_4774234_11 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007222 316.0
HFD2_k127_4774234_12 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000219 284.0
HFD2_k127_4774234_13 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000005814 242.0
HFD2_k127_4774234_14 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000001097 249.0
HFD2_k127_4774234_15 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000001454 233.0
HFD2_k127_4774234_16 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000001017 214.0
HFD2_k127_4774234_17 Glycoside hydrolase family 3 K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000001369 213.0
HFD2_k127_4774234_18 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000001533 204.0
HFD2_k127_4774234_19 GAF domain-containing protein K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000167 195.0
HFD2_k127_4774234_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 515.0
HFD2_k127_4774234_20 Peptidase family M3 K08602 - - 0.00000000000000000000000000000000000000000000001035 198.0
HFD2_k127_4774234_21 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000002533 183.0
HFD2_k127_4774234_22 Phage integrase family - - - 0.00000000000000000000000000000000000000000001029 169.0
HFD2_k127_4774234_23 lipid kinase activity - - - 0.00000000000000000000000000000000000000000007296 184.0
HFD2_k127_4774234_24 response regulator receiver - - - 0.000000000000000000000000000000000000000005924 178.0
HFD2_k127_4774234_25 Phospholipase/Carboxylesterase K01061 - 3.1.1.45 0.0000000000000000000000000000000000003255 149.0
HFD2_k127_4774234_26 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000004663 136.0
HFD2_k127_4774234_27 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000144 131.0
HFD2_k127_4774234_28 PFAM Methyltransferase type - - - 0.0000000000000000000006408 112.0
HFD2_k127_4774234_29 PFAM blue (type 1) copper domain protein - - - 0.000000000000000001506 98.0
HFD2_k127_4774234_3 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 496.0
HFD2_k127_4774234_30 PFAM Glycosyl hydrolase family 32 K01193 - 3.2.1.26 0.0000000000000002241 94.0
HFD2_k127_4774234_31 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000002003 85.0
HFD2_k127_4774234_32 Belongs to the glycosyl hydrolase 13 family - - - 0.0000001305 65.0
HFD2_k127_4774234_33 Methyltransferase domain - - - 0.0000007738 62.0
HFD2_k127_4774234_34 Tetratricopeptide repeat - - - 0.000007224 59.0
HFD2_k127_4774234_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 486.0
HFD2_k127_4774234_5 8-amino-7-oxononanoate synthase activity K00639,K00652 - 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 387.0
HFD2_k127_4774234_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009931 370.0
HFD2_k127_4774234_7 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 329.0
HFD2_k127_4774234_8 PFAM aminotransferase class V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 325.0
HFD2_k127_4774234_9 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 326.0
HFD2_k127_4824839_0 Protein of unknown function, DUF255 K06888 - - 2.896e-209 674.0
HFD2_k127_4824839_1 Type II IV secretion system protein K02454,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 527.0
HFD2_k127_4824839_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000001799 113.0
HFD2_k127_4824839_11 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000007866 78.0
HFD2_k127_4824839_2 Cytochrome c biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 479.0
HFD2_k127_4824839_3 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 478.0
HFD2_k127_4824839_4 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 370.0
HFD2_k127_4824839_5 Aspartyl protease - - - 0.000000000000000000000000000000000000000000000000000006096 213.0
HFD2_k127_4824839_6 endonuclease activity K07451 - - 0.00000000000000000000000000000000000000000000000005016 193.0
HFD2_k127_4824839_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000003071 192.0
HFD2_k127_4824839_8 Peptidase M50 - - - 0.00000000000000000000000000000000000000000006424 168.0
HFD2_k127_4824839_9 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000002703 164.0
HFD2_k127_489467_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 541.0
HFD2_k127_489467_1 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 488.0
HFD2_k127_489467_10 methylamine metabolic process - - - 0.000000000000004903 87.0
HFD2_k127_489467_11 metal cluster binding K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0000000004692 68.0
HFD2_k127_489467_2 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003103 482.0
HFD2_k127_489467_3 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01739,K01761 - 2.5.1.48,4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 470.0
HFD2_k127_489467_4 Belongs to the 5'-nucleotidase family - - - 0.000000000000000000000000000000000000005646 161.0
HFD2_k127_489467_5 - - - - 0.0000000000000000000000000000695 131.0
HFD2_k127_489467_6 endonuclease activity K07451 - - 0.0000000000000000000000009192 116.0
HFD2_k127_489467_7 Putative adhesin - - - 0.0000000000000000000245 105.0
HFD2_k127_489467_8 Polymer-forming cytoskeletal - - - 0.0000000000000002602 94.0
HFD2_k127_489467_9 Rhodanese Homology Domain - - - 0.000000000000001271 87.0
HFD2_k127_4964808_0 DNA topoisomerase II activity K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009432 517.0
HFD2_k127_4964808_1 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000434 266.0
HFD2_k127_4964808_2 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000009839 203.0
HFD2_k127_4964808_3 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000538 208.0
HFD2_k127_4964808_4 pfam abc K01990 - - 0.0000000000000000000000000000000000000000003894 181.0
HFD2_k127_4964808_5 EamA-like transporter family - - - 0.000000000000000000000000001619 123.0
HFD2_k127_5047022_0 Belongs to the ABC transporter superfamily K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 353.0
HFD2_k127_5047022_1 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.0000000000000000000000000000000002047 136.0
HFD2_k127_5047022_2 EamA-like transporter family - - - 0.000000000000003028 86.0
HFD2_k127_5336472_0 - - - - 3.796e-195 637.0
HFD2_k127_5336472_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 480.0
HFD2_k127_5336472_2 Integral membrane sensor signal transduction histidine kinase K07709,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003288 283.0
HFD2_k127_5336472_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000002743 226.0
HFD2_k127_5336472_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000007615 215.0
HFD2_k127_5336472_5 endonuclease activity K07451 - - 0.000000000000000000000000000127 122.0
HFD2_k127_5336472_6 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000003836 97.0
HFD2_k127_5388205_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 558.0
HFD2_k127_5388205_1 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 517.0
HFD2_k127_5388205_10 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002183 271.0
HFD2_k127_5388205_11 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000009872 221.0
HFD2_k127_5388205_12 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000003584 180.0
HFD2_k127_5388205_13 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000141 130.0
HFD2_k127_5388205_14 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000008546 109.0
HFD2_k127_5388205_15 ATP hydrolysis coupled proton transport - - - 0.00000000000000000167 100.0
HFD2_k127_5388205_16 GtrA-like protein K00995 - 2.7.8.5 0.0000000000000005848 82.0
HFD2_k127_5388205_17 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000007714 89.0
HFD2_k127_5388205_18 peptidyl-tyrosine sulfation - - - 0.00000000000006 85.0
HFD2_k127_5388205_19 zinc-ribbon domain - - - 0.00001161 55.0
HFD2_k127_5388205_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 448.0
HFD2_k127_5388205_20 Cell division protein FtsQ K03589 - - 0.00001647 58.0
HFD2_k127_5388205_21 antisigma factor binding K02066,K04749 - - 0.0002404 53.0
HFD2_k127_5388205_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 446.0
HFD2_k127_5388205_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 420.0
HFD2_k127_5388205_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 419.0
HFD2_k127_5388205_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 355.0
HFD2_k127_5388205_7 Penicillin-binding Protein dimerisation domain K03587,K08384,K08724,K12552,K12556 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 349.0
HFD2_k127_5388205_8 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003875 302.0
HFD2_k127_5388205_9 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000007933 288.0
HFD2_k127_5418440_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 5.315e-209 659.0
HFD2_k127_5418440_1 5'-nucleotidase K01081,K01119,K11751 - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 586.0
HFD2_k127_5418440_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000007354 256.0
HFD2_k127_5418440_11 tail specific protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001856 269.0
HFD2_k127_5418440_12 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003671 253.0
HFD2_k127_5418440_13 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002285 266.0
HFD2_k127_5418440_14 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000000000000000000000000000000000000000006393 243.0
HFD2_k127_5418440_15 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000003812 209.0
HFD2_k127_5418440_16 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000001044 211.0
HFD2_k127_5418440_17 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.00000000000000000000000000000000000000000000000000006628 197.0
HFD2_k127_5418440_18 Domains HisKA, HATPase_c - - - 0.0000000000000000000000000000000000000000006441 175.0
HFD2_k127_5418440_19 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000002656 151.0
HFD2_k127_5418440_2 transporter, DctM subunit K11690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 536.0
HFD2_k127_5418440_20 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000002404 122.0
HFD2_k127_5418440_21 Binds the 23S rRNA K02909 - - 0.0000000000000000001354 95.0
HFD2_k127_5418440_22 - - - - 0.000000000000000002182 94.0
HFD2_k127_5418440_23 long-chain fatty acid transporting porin activity - - - 0.0000000000008837 79.0
HFD2_k127_5418440_24 YbbR-like protein - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.00000000005848 76.0
HFD2_k127_5418440_25 protein conserved in bacteria - - - 0.0000000003114 73.0
HFD2_k127_5418440_26 transcriptional regulator, SARP family - - - 0.0001838 54.0
HFD2_k127_5418440_27 Tetratricopeptide repeat - - - 0.0005777 51.0
HFD2_k127_5418440_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 407.0
HFD2_k127_5418440_4 pyridine nucleotide-disulphide oxidoreductase dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 392.0
HFD2_k127_5418440_5 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 366.0
HFD2_k127_5418440_6 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 377.0
HFD2_k127_5418440_7 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 353.0
HFD2_k127_5418440_8 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004614 333.0
HFD2_k127_5418440_9 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001037 276.0
HFD2_k127_5498020_0 phosphorelay signal transduction system K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 364.0
HFD2_k127_5516773_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 9.461e-265 852.0
HFD2_k127_5516773_1 PFAM GlcNAc-PI de-N-acetylase - - - 9.823e-255 811.0
HFD2_k127_5516773_10 beta-glucosidase activity K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 364.0
HFD2_k127_5516773_11 Sterol carrier protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 364.0
HFD2_k127_5516773_12 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 375.0
HFD2_k127_5516773_13 amino acid activation for nonribosomal peptide biosynthetic process K17713,K20952 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 368.0
HFD2_k127_5516773_14 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 329.0
HFD2_k127_5516773_15 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004208 295.0
HFD2_k127_5516773_16 PFAM CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000000000000000003535 224.0
HFD2_k127_5516773_17 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000000004782 224.0
HFD2_k127_5516773_18 pilus organization K02674,K07004 - - 0.000000000000000000000000000000000000000000000000302 200.0
HFD2_k127_5516773_19 Tetratricopeptide repeat protein - - - 0.00000000000000000000000000000000000000000000000961 198.0
HFD2_k127_5516773_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 4.891e-204 649.0
HFD2_k127_5516773_20 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000001226 183.0
HFD2_k127_5516773_21 - - - - 0.00000000000000000000000000000000000000000000001805 197.0
HFD2_k127_5516773_22 - - - - 0.000000000000000000000000000000000000000000000142 194.0
HFD2_k127_5516773_23 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000006728 170.0
HFD2_k127_5516773_24 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000001599 186.0
HFD2_k127_5516773_25 CHRD domain - - - 0.00000000000000000000000000000000000000000001702 170.0
HFD2_k127_5516773_26 - - - - 0.000000000000000000000000000000000000000000266 167.0
HFD2_k127_5516773_27 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000001326 169.0
HFD2_k127_5516773_28 Tetratricopeptide repeat protein - - - 0.000000000000000000000000000000000000000007706 176.0
HFD2_k127_5516773_29 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000006995 156.0
HFD2_k127_5516773_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 618.0
HFD2_k127_5516773_30 amino acid activation for nonribosomal peptide biosynthetic process K17713,K20952 - - 0.000000000000000000000000000001045 140.0
HFD2_k127_5516773_31 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000001497 126.0
HFD2_k127_5516773_32 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000001805 111.0
HFD2_k127_5516773_33 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000003004 125.0
HFD2_k127_5516773_34 Photosynthetic reaction centre cytochrome C subunit - - - 0.00000000000000000001215 101.0
HFD2_k127_5516773_35 translation release factor activity K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000003495 89.0
HFD2_k127_5516773_36 - - - - 0.000000000008705 73.0
HFD2_k127_5516773_37 cellulase activity K01179,K01361,K13277,K21449 - 3.2.1.4,3.4.21.96 0.00000003166 65.0
HFD2_k127_5516773_38 Protein of unknown function (DUF3311) - - - 0.000003179 53.0
HFD2_k127_5516773_39 FlgD Ig-like domain - - - 0.000005986 59.0
HFD2_k127_5516773_4 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 665.0
HFD2_k127_5516773_40 cellulose binding - - - 0.000006486 60.0
HFD2_k127_5516773_41 Belongs to the glycosyl hydrolase 43 family - - - 0.00001199 59.0
HFD2_k127_5516773_42 Periplasmic copper-binding protein (NosD) - - - 0.0000149 57.0
HFD2_k127_5516773_43 Putative peptidoglycan binding domain K01388,K01394,K01402,K07763,K07994,K07999 - 3.4.24.17,3.4.24.34,3.4.24.7,3.4.24.80 0.00005202 55.0
HFD2_k127_5516773_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 582.0
HFD2_k127_5516773_6 acyl-CoA dehydrogenase activity K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 516.0
HFD2_k127_5516773_7 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 467.0
HFD2_k127_5516773_8 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 460.0
HFD2_k127_5516773_9 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 397.0
HFD2_k127_5531380_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 5.396e-231 758.0
HFD2_k127_5531380_1 Prolyl oligopeptidase family - - - 6.858e-210 674.0
HFD2_k127_5531380_10 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 422.0
HFD2_k127_5531380_11 Sortilin, neurotensin receptor 3, - - - 0.000000000000000000000000000000000000000000000000000000000000000004456 258.0
HFD2_k127_5531380_12 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000001042 232.0
HFD2_k127_5531380_13 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000002759 190.0
HFD2_k127_5531380_14 domain protein K02674,K07004 - - 0.0000000000000000000000000000000000000000000000125 198.0
HFD2_k127_5531380_15 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000002239 171.0
HFD2_k127_5531380_16 TPM domain K06872 - - 0.00000000000000000000000000000000004749 152.0
HFD2_k127_5531380_17 Psort location Cytoplasmic, score K09707 - - 0.000000000000000000000000000007004 124.0
HFD2_k127_5531380_18 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000006785 126.0
HFD2_k127_5531380_19 nucleotidyltransferase activity - - - 0.00000000000000003621 91.0
HFD2_k127_5531380_2 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 604.0
HFD2_k127_5531380_20 4Fe-4S single cluster domain K05337 - - 0.00001418 50.0
HFD2_k127_5531380_21 SMART PAS domain containing protein - - - 0.00005036 55.0
HFD2_k127_5531380_3 MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 563.0
HFD2_k127_5531380_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 563.0
HFD2_k127_5531380_5 Peptidase dimerisation domain K01436,K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 497.0
HFD2_k127_5531380_6 Ankyrin repeats (many copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 466.0
HFD2_k127_5531380_7 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 448.0
HFD2_k127_5531380_8 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 455.0
HFD2_k127_5531380_9 activity, protein serine threonine kinase activity, protein-tyrosine kinase activity, ATP binding, regulation of transcription, DNA-dependent, protein amino acid phosphorylation K08282 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 443.0
HFD2_k127_5606104_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 390.0
HFD2_k127_5606104_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005466 362.0
HFD2_k127_5606104_10 Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro K07025 - - 0.0000000000000000000003912 104.0
HFD2_k127_5606104_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000001448 65.0
HFD2_k127_5606104_12 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000002527 59.0
HFD2_k127_5606104_13 PFAM Peptidase M56, BlaR1 - - - 0.0003157 46.0
HFD2_k127_5606104_2 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 315.0
HFD2_k127_5606104_3 Metallopeptidase family M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000002896 272.0
HFD2_k127_5606104_4 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009175 258.0
HFD2_k127_5606104_5 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001477 248.0
HFD2_k127_5606104_6 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000001148 235.0
HFD2_k127_5606104_7 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000001816 199.0
HFD2_k127_5606104_8 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000001687 142.0
HFD2_k127_5606104_9 PFAM Cold-shock protein, DNA-binding K03704 - - 0.000000000000000000000000004241 116.0
HFD2_k127_5669545_0 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 2.882e-277 865.0
HFD2_k127_5669545_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008474 558.0
HFD2_k127_5669545_10 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 322.0
HFD2_k127_5669545_11 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 320.0
HFD2_k127_5669545_12 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002212 298.0
HFD2_k127_5669545_13 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000000004817 281.0
HFD2_k127_5669545_14 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005892 258.0
HFD2_k127_5669545_15 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000001686 243.0
HFD2_k127_5669545_16 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000003408 243.0
HFD2_k127_5669545_17 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000009281 204.0
HFD2_k127_5669545_18 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000003358 218.0
HFD2_k127_5669545_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000006926 197.0
HFD2_k127_5669545_2 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 506.0
HFD2_k127_5669545_20 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000007059 197.0
HFD2_k127_5669545_21 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000005203 190.0
HFD2_k127_5669545_22 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000008544 161.0
HFD2_k127_5669545_23 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000001211 165.0
HFD2_k127_5669545_24 RNA polymerase sigma factor K03088 - - 0.000000000000000000000000000000000001352 146.0
HFD2_k127_5669545_25 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000001101 154.0
HFD2_k127_5669545_26 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000001375 155.0
HFD2_k127_5669545_27 Belongs to the BshC family K22136 - - 0.0000000000000000000000000000000005767 149.0
HFD2_k127_5669545_28 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000001635 134.0
HFD2_k127_5669545_29 OmpA family K03640 - - 0.00000000000000000000000000000007082 143.0
HFD2_k127_5669545_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 474.0
HFD2_k127_5669545_30 Glutathione peroxidase K02199 - - 0.0000000000000000000000000009092 123.0
HFD2_k127_5669545_31 Tetratricopeptide repeat - - - 0.00000000000000000000000003961 126.0
HFD2_k127_5669545_32 Biopolymer transport protein ExbD/TolR K03560 - - 0.00000000000000000000001113 113.0
HFD2_k127_5669545_33 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000001672 93.0
HFD2_k127_5669545_34 Peptidase M56 - - - 0.0000000000000007613 91.0
HFD2_k127_5669545_35 energy transducer activity K03646,K03832 - - 0.0000000000000309 81.0
HFD2_k127_5669545_36 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.000000000005975 75.0
HFD2_k127_5669545_37 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000004746 66.0
HFD2_k127_5669545_38 Preprotein translocase SecG subunit K03075 - - 0.000000001371 68.0
HFD2_k127_5669545_39 Belongs to the peptidase S8 family - - - 0.0000007245 51.0
HFD2_k127_5669545_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 425.0
HFD2_k127_5669545_40 Alternative locus ID K00748 - 2.4.1.182 0.0008282 42.0
HFD2_k127_5669545_5 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 412.0
HFD2_k127_5669545_6 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 380.0
HFD2_k127_5669545_7 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 370.0
HFD2_k127_5669545_8 Glycosyl transferase 4-like K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 380.0
HFD2_k127_5669545_9 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 342.0
HFD2_k127_5693627_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0 1063.0
HFD2_k127_5693627_1 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 646.0
HFD2_k127_5693627_10 PFAM OsmC family protein K07397 - - 0.00000000000000000000006605 114.0
HFD2_k127_5693627_11 PFAM secretion protein HlyD family protein K03543 - - 0.000000000000000007925 98.0
HFD2_k127_5693627_12 lactoylglutathione lyase activity - - - 0.00000000000000002335 88.0
HFD2_k127_5693627_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008282 469.0
HFD2_k127_5693627_3 Mo-molybdopterin cofactor biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 317.0
HFD2_k127_5693627_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885,K15977 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000412 251.0
HFD2_k127_5693627_5 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000001099 236.0
HFD2_k127_5693627_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000009949 236.0
HFD2_k127_5693627_7 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000001409 222.0
HFD2_k127_5693627_8 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000002239 212.0
HFD2_k127_5693627_9 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000001801 207.0
HFD2_k127_5698552_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000003897 222.0
HFD2_k127_5698552_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000001036 201.0
HFD2_k127_5793776_0 cellulose binding - - - 2.904e-280 897.0
HFD2_k127_5793776_1 4Fe-4S binding domain - - - 5.135e-244 779.0
HFD2_k127_5793776_2 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 365.0
HFD2_k127_5793776_4 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000003122 156.0
HFD2_k127_5802971_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.801e-302 952.0
HFD2_k127_5802971_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.497e-264 831.0
HFD2_k127_5802971_10 Belongs to the ParA family K04562 - - 0.000000000000000000000000000000000000000000000000000004835 208.0
HFD2_k127_5802971_11 Belongs to the sigma-70 factor family K02405 - - 0.0000000000000000000000000000000000000000000000000007339 206.0
HFD2_k127_5802971_12 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000007423 193.0
HFD2_k127_5802971_13 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.00000000000000000000000000000000000000000000001211 199.0
HFD2_k127_5802971_14 Glycosyl transferase, family 2 K00721,K01912,K08301 - 2.4.1.83,6.2.1.30 0.000000000000000000000000000000000000000000001642 177.0
HFD2_k127_5802971_15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000002102 160.0
HFD2_k127_5802971_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000001087 151.0
HFD2_k127_5802971_17 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000001083 137.0
HFD2_k127_5802971_18 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000005387 141.0
HFD2_k127_5802971_19 enzyme binding K00567,K07443 - 2.1.1.63 0.0000000000000000000000000002168 126.0
HFD2_k127_5802971_2 PFAM UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 415.0
HFD2_k127_5802971_20 helix_turn_helix, Lux Regulon K14987 - - 0.0000000000000008694 87.0
HFD2_k127_5802971_21 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000002452 51.0
HFD2_k127_5802971_22 Two component regulator propeller - - - 0.0008592 53.0
HFD2_k127_5802971_3 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 349.0
HFD2_k127_5802971_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000013 272.0
HFD2_k127_5802971_5 Peptidase, S8 S53 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004375 263.0
HFD2_k127_5802971_6 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000002981 236.0
HFD2_k127_5802971_7 Peptidase, S8 S53 family - - - 0.00000000000000000000000000000000000000000000000000000000000000005398 252.0
HFD2_k127_5802971_8 Domain of unknown function (DUF4139) - - - 0.00000000000000000000000000000000000000000000000000000001173 215.0
HFD2_k127_5802971_9 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000003849 215.0
HFD2_k127_5849655_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.492e-257 802.0
HFD2_k127_5849655_1 Domain of unknown function (DUF5117) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 552.0
HFD2_k127_5849655_10 COG2143 Thioredoxin-related protein - - - 0.00000000000000000000000000001078 125.0
HFD2_k127_5849655_11 EXOIII K02342 - 2.7.7.7 0.000000000000000000000000002898 118.0
HFD2_k127_5849655_12 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000003882 90.0
HFD2_k127_5849655_13 B3/4 domain - - - 0.000000000001892 74.0
HFD2_k127_5849655_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000263 81.0
HFD2_k127_5849655_15 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000161 68.0
HFD2_k127_5849655_16 Domain of unknown function (DUF1929) - - - 0.0000009825 61.0
HFD2_k127_5849655_2 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 505.0
HFD2_k127_5849655_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 319.0
HFD2_k127_5849655_4 response regulator K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000001702 228.0
HFD2_k127_5849655_5 ATP cob(I)alamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000001967 188.0
HFD2_k127_5849655_6 Calcineurin-like phosphoesterase K07096 - - 0.0000000000000000000000000000000000000000000005256 179.0
HFD2_k127_5849655_7 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000006658 186.0
HFD2_k127_5849655_8 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000007527 137.0
HFD2_k127_5849655_9 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000002604 134.0
HFD2_k127_5852035_0 Cupredoxin-like domain K00376 - 1.7.2.4 1.547e-225 726.0
HFD2_k127_5852035_1 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 2.599e-225 751.0
HFD2_k127_5852035_10 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000002708 138.0
HFD2_k127_5852035_11 NnrS protein K07234 - - 0.000000000000000000000000003237 129.0
HFD2_k127_5852035_12 Cytochrome c - - - 0.0000000000000000002986 98.0
HFD2_k127_5852035_13 PFAM UspA domain protein K06149 - - 0.00000000000000008261 88.0
HFD2_k127_5852035_14 Lamin Tail Domain - - - 0.00000000000000116 91.0
HFD2_k127_5852035_15 cytochrome c K00406 - - 0.0000000000004277 80.0
HFD2_k127_5852035_16 Non-ribosomal peptide synthetase modules and related proteins - - - 0.000000009505 67.0
HFD2_k127_5852035_17 Two component regulator propeller - - - 0.00000002048 67.0
HFD2_k127_5852035_18 - - - - 0.0000007609 61.0
HFD2_k127_5852035_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 - 3.6.3.9 2.332e-216 709.0
HFD2_k127_5852035_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00124,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 325.0
HFD2_k127_5852035_4 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000003824 240.0
HFD2_k127_5852035_5 ABC transporter K01990,K19340 - - 0.000000000000000000000000000000000000000000000008604 188.0
HFD2_k127_5852035_6 ABC-2 family transporter protein K01992,K19341 - - 0.0000000000000000000000000000000000000002225 166.0
HFD2_k127_5852035_7 - - - - 0.000000000000000000000000000000000000001075 168.0
HFD2_k127_5852035_8 OsmC-like protein - - - 0.000000000000000000000000000000000009127 142.0
HFD2_k127_5852035_9 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000483 144.0
HFD2_k127_5859684_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 432.0
HFD2_k127_5859684_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005919 395.0
HFD2_k127_5859684_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000001553 86.0
HFD2_k127_5859684_11 Sporulation and spore germination - - - 0.0000002619 64.0
HFD2_k127_5859684_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008445 293.0
HFD2_k127_5859684_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000054 280.0
HFD2_k127_5859684_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000001403 194.0
HFD2_k127_5859684_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000001452 180.0
HFD2_k127_5859684_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000008565 154.0
HFD2_k127_5859684_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000006355 132.0
HFD2_k127_5859684_8 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000001194 108.0
HFD2_k127_5859684_9 iron dependent repressor K03709 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000007335 91.0
HFD2_k127_6082065_0 response regulator K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 405.0
HFD2_k127_6082065_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 308.0
HFD2_k127_6082065_10 Polymer-forming cytoskeletal - - - 0.00000006502 64.0
HFD2_k127_6082065_11 - - - - 0.0000258 54.0
HFD2_k127_6082065_12 Putative zinc-finger - - - 0.00009276 54.0
HFD2_k127_6082065_2 transcription factor binding K02584,K11914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 327.0
HFD2_k127_6082065_3 cellulase activity K06882 - - 0.00000000000000000000000000000000000000000000000000000003916 207.0
HFD2_k127_6082065_4 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000002717 183.0
HFD2_k127_6082065_5 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000001196 166.0
HFD2_k127_6082065_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000002507 153.0
HFD2_k127_6082065_7 surface antigen - - - 0.000000000000000000000003714 117.0
HFD2_k127_6082065_8 cell adhesion involved in biofilm formation - - - 0.00000000000000000001653 106.0
HFD2_k127_6082065_9 PFAM regulatory protein, ArsR K21903 - - 0.000000002234 66.0
HFD2_k127_6140392_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.119e-263 852.0
HFD2_k127_6140392_1 succinate dehydrogenase K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 8.309e-251 790.0
HFD2_k127_6140392_10 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 343.0
HFD2_k127_6140392_11 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 340.0
HFD2_k127_6140392_12 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 336.0
HFD2_k127_6140392_13 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 307.0
HFD2_k127_6140392_14 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004871 279.0
HFD2_k127_6140392_15 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003402 256.0
HFD2_k127_6140392_16 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000003286 247.0
HFD2_k127_6140392_17 Conserved hypothetical protein 698 - - - 0.000000000000000000000000000000000000000000000000000000000000000007063 237.0
HFD2_k127_6140392_18 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000000000000009023 220.0
HFD2_k127_6140392_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000007908 218.0
HFD2_k127_6140392_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 559.0
HFD2_k127_6140392_20 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000158 223.0
HFD2_k127_6140392_21 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000335 211.0
HFD2_k127_6140392_22 Peptidase family M23 K21471 GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000000001806 193.0
HFD2_k127_6140392_23 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000004286 198.0
HFD2_k127_6140392_24 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000004414 174.0
HFD2_k127_6140392_25 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000225 160.0
HFD2_k127_6140392_26 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000007255 169.0
HFD2_k127_6140392_27 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000001045 161.0
HFD2_k127_6140392_28 CoA binding domain K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000004634 141.0
HFD2_k127_6140392_29 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000006527 154.0
HFD2_k127_6140392_3 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 496.0
HFD2_k127_6140392_30 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000005317 151.0
HFD2_k127_6140392_31 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.00000000000000000000000000000000909 145.0
HFD2_k127_6140392_32 peptidyl-prolyl cis-trans isomerase activity K03769,K03771,K07533 - 5.2.1.8 0.0000000000000000000000000000001176 141.0
HFD2_k127_6140392_33 Histidine kinase - - - 0.0000000000000000000000000000002132 143.0
HFD2_k127_6140392_34 Belongs to the ompA family - - - 0.0000000000000000000000000000003529 134.0
HFD2_k127_6140392_35 Isoprenylcysteine carboxyl methyltransferase K16168 - - 0.0000000000000000000000000000007657 139.0
HFD2_k127_6140392_36 Exodeoxyribonuclease III - - - 0.000000000000000000000000000002348 139.0
HFD2_k127_6140392_37 Transposase, Mutator family - - - 0.00000000000000000000001366 102.0
HFD2_k127_6140392_38 PAS domain - - - 0.000000000000000000006122 93.0
HFD2_k127_6140392_4 PFAM metal-dependent phosphohydrolase, HD sub domain - GO:0003674,GO:0003824,GO:0004112,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009187,GO:0009214,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009607 414.0
HFD2_k127_6140392_40 BNR/Asp-box repeat - - - 0.00000000000000000005111 104.0
HFD2_k127_6140392_41 AraC-like ligand binding domain - - - 0.0000000000000000003862 103.0
HFD2_k127_6140392_42 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000547 85.0
HFD2_k127_6140392_43 PPIC-type PPIASE domain K01802,K03769 - 5.2.1.8 0.00000000000001836 87.0
HFD2_k127_6140392_44 methyltransferase K21459 - 2.1.1.301 0.00000000000008892 83.0
HFD2_k127_6140392_45 Belongs to the glycosyl hydrolase 13 family - - - 0.0000000000308 77.0
HFD2_k127_6140392_46 PFAM blue (type 1) copper domain protein - - - 0.00000000003495 74.0
HFD2_k127_6140392_47 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.000000009502 60.0
HFD2_k127_6140392_48 - - - - 0.00000005042 64.0
HFD2_k127_6140392_49 regulation of response to stimulus K06889,K09914 - - 0.00000005659 67.0
HFD2_k127_6140392_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 399.0
HFD2_k127_6140392_50 Endonuclease I - - - 0.00000009818 65.0
HFD2_k127_6140392_52 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000003527 58.0
HFD2_k127_6140392_53 TPR repeat-containing protein - - - 0.00001444 58.0
HFD2_k127_6140392_54 Cation transport ATPase K17686 - 3.6.3.54 0.00007723 49.0
HFD2_k127_6140392_55 Glycosyl transferase family 41 - - - 0.0001007 56.0
HFD2_k127_6140392_56 - - - - 0.0004048 53.0
HFD2_k127_6140392_6 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 380.0
HFD2_k127_6140392_7 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 374.0
HFD2_k127_6140392_8 Chalcone and stilbene synthases, N-terminal domain K16167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 361.0
HFD2_k127_6140392_9 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 353.0
HFD2_k127_6179169_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 6.931e-242 797.0
HFD2_k127_6179169_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 482.0
HFD2_k127_6179169_2 amino acid activation for nonribosomal peptide biosynthetic process K17713,K20952 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 420.0
HFD2_k127_6179169_3 Creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009795 321.0
HFD2_k127_6179169_4 Creatinase/Prolidase N-terminal domain K01271,K01274 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000001949 270.0
HFD2_k127_6179169_5 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000001685 267.0
HFD2_k127_6179169_6 endonuclease activity K07451 - - 0.000000000000000000000001299 112.0
HFD2_k127_6179169_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000456 113.0
HFD2_k127_622077_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 3.257e-302 949.0
HFD2_k127_622077_1 Major Facilitator Superfamily K02445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 584.0
HFD2_k127_622077_10 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 318.0
HFD2_k127_622077_11 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 304.0
HFD2_k127_622077_12 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 308.0
HFD2_k127_622077_13 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 295.0
HFD2_k127_622077_14 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001807 294.0
HFD2_k127_622077_15 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002181 291.0
HFD2_k127_622077_16 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007899 264.0
HFD2_k127_622077_17 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000101 273.0
HFD2_k127_622077_18 AAA ATPase K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005468 243.0
HFD2_k127_622077_19 Xanthine and CO dehydrogenases maturation factor XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000006308 250.0
HFD2_k127_622077_2 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 478.0
HFD2_k127_622077_20 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000001944 246.0
HFD2_k127_622077_21 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.0000000000000000000000000000000000000000000000000000000000005547 218.0
HFD2_k127_622077_22 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000006004 220.0
HFD2_k127_622077_23 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000008685 193.0
HFD2_k127_622077_24 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000004638 184.0
HFD2_k127_622077_25 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000009684 190.0
HFD2_k127_622077_26 CcmB protein K02193,K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.0000000000000000000000000000000000000000001566 169.0
HFD2_k127_622077_27 PFAM ABC transporter related K02193 - 3.6.3.41 0.0000000000000000000000000000000000003709 159.0
HFD2_k127_622077_28 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 0.000000000000000000000000000000000002003 142.0
HFD2_k127_622077_29 cellulose binding K12132 - 2.7.11.1 0.0000000000000000000000000000004373 143.0
HFD2_k127_622077_3 Cytochrome C assembly protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006998 464.0
HFD2_k127_622077_30 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - 0.00000000000000000000002306 105.0
HFD2_k127_622077_31 Rieske [2Fe-2S] domain - - - 0.00000000000000000000005286 111.0
HFD2_k127_622077_32 NifU-like domain - - - 0.0000000000000000000456 93.0
HFD2_k127_622077_33 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000001808 102.0
HFD2_k127_622077_35 - - - - 0.0000000000002026 73.0
HFD2_k127_622077_36 MobA-related protein K07141,K19190 - 1.1.1.328,2.7.7.76 0.000000000002981 80.0
HFD2_k127_622077_37 Domain of unknown function (DUF4114) - - - 0.0000000002315 70.0
HFD2_k127_622077_4 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 437.0
HFD2_k127_622077_5 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 421.0
HFD2_k127_622077_6 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 381.0
HFD2_k127_622077_7 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 356.0
HFD2_k127_622077_8 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004831 355.0
HFD2_k127_622077_9 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 343.0
HFD2_k127_6232110_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 488.0
HFD2_k127_6232110_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 434.0
HFD2_k127_6232110_10 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000099 310.0
HFD2_k127_6232110_11 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006367 302.0
HFD2_k127_6232110_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000003923 222.0
HFD2_k127_6232110_13 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000008448 202.0
HFD2_k127_6232110_14 Lumazine binding domain K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000000000002046 204.0
HFD2_k127_6232110_15 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000003526 197.0
HFD2_k127_6232110_16 methyltransferase - - - 0.000000000000000000000000000000000000000000000000004404 198.0
HFD2_k127_6232110_17 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000000001283 199.0
HFD2_k127_6232110_18 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000000000000000008114 156.0
HFD2_k127_6232110_19 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000165 167.0
HFD2_k127_6232110_2 Protein of unknown function (DUF2723) K16928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006306 397.0
HFD2_k127_6232110_20 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000001836 147.0
HFD2_k127_6232110_21 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000005489 142.0
HFD2_k127_6232110_22 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K07027 - - 0.00000000000000000000000000006429 130.0
HFD2_k127_6232110_23 Two component regulator propeller - - - 0.0000000000000000000000001252 124.0
HFD2_k127_6232110_24 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000006942 106.0
HFD2_k127_6232110_25 Polysaccharide biosynthesis protein - - - 0.00000000000000005526 95.0
HFD2_k127_6232110_26 Belongs to the 'phage' integrase family - - - 0.000000000000009415 85.0
HFD2_k127_6232110_27 Putative zinc-finger - - - 0.00000000001639 72.0
HFD2_k127_6232110_28 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000009884 61.0
HFD2_k127_6232110_29 COG0500 SAM-dependent methyltransferases - - - 0.000008254 58.0
HFD2_k127_6232110_3 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 356.0
HFD2_k127_6232110_4 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 338.0
HFD2_k127_6232110_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 338.0
HFD2_k127_6232110_6 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 322.0
HFD2_k127_6232110_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 312.0
HFD2_k127_6232110_8 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 308.0
HFD2_k127_6232110_9 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004916 291.0
HFD2_k127_6287770_0 AcrB/AcrD/AcrF family - - - 7.36e-307 983.0
HFD2_k127_6287770_1 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 1.741e-298 966.0
HFD2_k127_6287770_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000006091 85.0
HFD2_k127_6287770_11 Outer membrane efflux protein - - - 0.00000000003134 76.0
HFD2_k127_6287770_12 PFAM Cyclic nucleotide-binding - - - 0.000000258 64.0
HFD2_k127_6287770_13 - - - - 0.000004138 57.0
HFD2_k127_6287770_14 chloride channel K03281 - - 0.00001253 53.0
HFD2_k127_6287770_15 PFAM NHL repeat containing protein - - - 0.00003227 56.0
HFD2_k127_6287770_2 6-phosphofructokinase activity K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006164 590.0
HFD2_k127_6287770_3 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 478.0
HFD2_k127_6287770_4 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 394.0
HFD2_k127_6287770_5 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 390.0
HFD2_k127_6287770_6 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003629 261.0
HFD2_k127_6287770_7 Putative zinc-finger K03088 - - 0.000000000000000000000000000000000000000000000000875 191.0
HFD2_k127_6287770_8 Protein of unknown function (DUF2892) - - - 0.00000000000000000000004013 99.0
HFD2_k127_6287770_9 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000003398 104.0
HFD2_k127_6382780_0 Malate synthase K01638 - 2.3.3.9 2.925e-228 717.0
HFD2_k127_6382780_1 xanthine dehydrogenase activity - - - 8.012e-225 721.0
HFD2_k127_6382780_10 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K17722 - 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 455.0
HFD2_k127_6382780_11 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 447.0
HFD2_k127_6382780_12 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 392.0
HFD2_k127_6382780_13 Binding-protein-dependent transport system inner membrane component K15582 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 353.0
HFD2_k127_6382780_14 Binding-protein-dependent transport system inner membrane component K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 334.0
HFD2_k127_6382780_15 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 332.0
HFD2_k127_6382780_16 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 342.0
HFD2_k127_6382780_17 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 342.0
HFD2_k127_6382780_18 6-phosphogluconolactonase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 317.0
HFD2_k127_6382780_19 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000265 282.0
HFD2_k127_6382780_2 Malate synthase K01638 - 2.3.3.9 3.23e-206 651.0
HFD2_k127_6382780_20 Integrin alpha (beta-propellor repeats). - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007002 289.0
HFD2_k127_6382780_21 - - - - 0.000000000000000000000000000000000000000000000000000000000000000037 229.0
HFD2_k127_6382780_22 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000005855 241.0
HFD2_k127_6382780_23 CO dehydrogenase flavoprotein C-terminal domain K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000002839 215.0
HFD2_k127_6382780_24 Polysaccharide biosynthesis C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000002913 215.0
HFD2_k127_6382780_25 - - - - 0.00000000000000000000000000000000000000000000000000000005509 215.0
HFD2_k127_6382780_26 Phosphodiester glycosidase - - - 0.000000000000000000000000000000000000000000000000002545 194.0
HFD2_k127_6382780_27 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000006478 195.0
HFD2_k127_6382780_28 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000002544 153.0
HFD2_k127_6382780_29 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000001614 146.0
HFD2_k127_6382780_3 WD40-like Beta Propeller Repeat - - - 5.469e-206 679.0
HFD2_k127_6382780_30 CAAX protease self-immunity K07052 - - 0.000000000000000000000000002618 124.0
HFD2_k127_6382780_32 Trypsin-like serine protease K01337 - 3.4.21.50 0.00000000000000000001846 100.0
HFD2_k127_6382780_33 methyltransferase - - - 0.000000000000000001752 96.0
HFD2_k127_6382780_35 Hydrolase, NUDIX family K03574 - 3.6.1.55 0.00000000000000001643 89.0
HFD2_k127_6382780_37 Alkylmercury lyase - - - 0.0000000000001459 74.0
HFD2_k127_6382780_39 Alkylmercury lyase - - - 0.0000000001528 64.0
HFD2_k127_6382780_4 Amidohydrolase family K01464 - 3.5.2.2 4.983e-196 621.0
HFD2_k127_6382780_40 Membrane - - - 0.0000001339 60.0
HFD2_k127_6382780_42 ketosteroid isomerase - - - 0.0000009138 61.0
HFD2_k127_6382780_43 - - - - 0.000001297 55.0
HFD2_k127_6382780_44 - - - - 0.000002298 56.0
HFD2_k127_6382780_45 curli production assembly transport component CsgG - - - 0.000009553 58.0
HFD2_k127_6382780_46 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00004334 55.0
HFD2_k127_6382780_47 asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0001037 48.0
HFD2_k127_6382780_48 Hsp90 protein K04079 - - 0.0003664 53.0
HFD2_k127_6382780_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 3.323e-195 625.0
HFD2_k127_6382780_6 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 613.0
HFD2_k127_6382780_7 isocitrate dehydrogenase activity K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 534.0
HFD2_k127_6382780_8 Carbon-nitrogen hydrolase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 512.0
HFD2_k127_6382780_9 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 517.0
HFD2_k127_6403386_0 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 526.0
HFD2_k127_6403386_1 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 505.0
HFD2_k127_6403386_10 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000001455 190.0
HFD2_k127_6403386_11 Dihydrodipicolinate reductase, C-terminus K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000004348 178.0
HFD2_k127_6403386_12 PFAM N-acetylmuramoyl-L-alanine amidase, family 2 - - - 0.000000000000001229 84.0
HFD2_k127_6403386_13 amino acid activation for nonribosomal peptide biosynthetic process K01183 - 3.2.1.14 0.000000003285 70.0
HFD2_k127_6403386_14 Bacterial Ig-like domain - - - 0.00000001096 68.0
HFD2_k127_6403386_15 Binds directly to 16S ribosomal RNA K02968 - - 0.00000001661 61.0
HFD2_k127_6403386_16 Protein conserved in bacteria - - - 0.0000002951 60.0
HFD2_k127_6403386_17 NHL repeat - - - 0.00001705 57.0
HFD2_k127_6403386_2 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 512.0
HFD2_k127_6403386_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 468.0
HFD2_k127_6403386_4 helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 446.0
HFD2_k127_6403386_5 nucleic acid phosphodiester bond hydrolysis K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 419.0
HFD2_k127_6403386_6 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 366.0
HFD2_k127_6403386_7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000005207 271.0
HFD2_k127_6403386_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000508 253.0
HFD2_k127_6403386_9 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000367 247.0
HFD2_k127_6407918_0 Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 406.0
HFD2_k127_6407918_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000007905 172.0
HFD2_k127_6407918_2 Zinc ion binding K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.0000000000000002239 91.0
HFD2_k127_6407918_3 6 heme-binding sites - - - 0.00000000000000393 88.0
HFD2_k127_6407918_4 - - - - 0.0000001491 63.0
HFD2_k127_6407918_5 cAMP biosynthetic process K21008 - - 0.000006315 55.0
HFD2_k127_6407918_6 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0006794 49.0
HFD2_k127_6592668_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.069e-275 870.0
HFD2_k127_6592668_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 1.301e-233 736.0
HFD2_k127_6592668_10 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 402.0
HFD2_k127_6592668_11 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 368.0
HFD2_k127_6592668_12 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 344.0
HFD2_k127_6592668_13 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 295.0
HFD2_k127_6592668_14 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 308.0
HFD2_k127_6592668_15 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 287.0
HFD2_k127_6592668_16 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000005598 263.0
HFD2_k127_6592668_17 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005013 241.0
HFD2_k127_6592668_18 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000009148 255.0
HFD2_k127_6592668_19 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000007968 203.0
HFD2_k127_6592668_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 594.0
HFD2_k127_6592668_20 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000001633 194.0
HFD2_k127_6592668_21 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000000000000000000009252 159.0
HFD2_k127_6592668_22 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000003321 158.0
HFD2_k127_6592668_23 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000001464 158.0
HFD2_k127_6592668_24 - - - - 0.0000000000000000000000000000000003012 132.0
HFD2_k127_6592668_25 aminotransferase class I and II - - - 0.0000000000000000000000000000003927 136.0
HFD2_k127_6592668_26 Yqey-like protein K09117 - - 0.000000000000000000000000002097 120.0
HFD2_k127_6592668_27 MgtC family K07507 - - 0.000000000000000000000000004053 126.0
HFD2_k127_6592668_28 - - - - 0.000000000000000000002269 107.0
HFD2_k127_6592668_29 deoxyhypusine monooxygenase activity - - - 0.000000000000000008775 96.0
HFD2_k127_6592668_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009522 576.0
HFD2_k127_6592668_30 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.0000000000004432 81.0
HFD2_k127_6592668_31 cytochrome C K00406 - - 0.00000006571 61.0
HFD2_k127_6592668_32 SMART Tetratricopeptide repeat - - - 0.0000001532 64.0
HFD2_k127_6592668_4 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 482.0
HFD2_k127_6592668_5 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 476.0
HFD2_k127_6592668_6 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005112 451.0
HFD2_k127_6592668_7 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 428.0
HFD2_k127_6592668_8 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 404.0
HFD2_k127_6592668_9 PFAM Glycosyl transferase family 2 K00786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 401.0
HFD2_k127_6616569_0 Acetyl-CoA hydrolase/transferase N-terminal domain K01067 - 3.1.2.1 6.802e-218 684.0
HFD2_k127_6616569_1 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 550.0
HFD2_k127_6616569_2 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 382.0
HFD2_k127_6616569_3 PFAM Sodium sulphate symporter K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002515 296.0
HFD2_k127_6616569_4 Cold shock protein K03704 - - 0.0000000000000000000000000003997 113.0
HFD2_k127_6616569_5 - K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.000000000000000000000000005064 118.0
HFD2_k127_6616569_6 Beta-lactamase - - - 0.0000000000122 66.0
HFD2_k127_6691175_0 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 586.0
HFD2_k127_6691175_1 PFAM Type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 413.0
HFD2_k127_6691175_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000002889 186.0
HFD2_k127_6691175_3 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000001197 143.0
HFD2_k127_6691175_4 BlaR1 peptidase M56 - - - 0.00000000000000000004263 100.0
HFD2_k127_6691175_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000005914 78.0
HFD2_k127_6762586_0 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 571.0
HFD2_k127_6762586_1 Anthranilate synthase component I, N terminal region K01657,K01665,K13950 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 375.0
HFD2_k127_6762586_10 PFAM GlcNAc-PI de-N-acetylase K01463 - - 0.000000000000000000000000000000000000000001289 167.0
HFD2_k127_6762586_11 domain protein - - - 0.00000000000000000000000000000000000000001081 167.0
HFD2_k127_6762586_12 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000004742 167.0
HFD2_k127_6762586_13 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000002347 161.0
HFD2_k127_6762586_14 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000001306 143.0
HFD2_k127_6762586_15 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.000000000000000000000000000001124 141.0
HFD2_k127_6762586_16 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000005271 131.0
HFD2_k127_6762586_17 Cache domain - - - 0.000000000000000000000000006219 122.0
HFD2_k127_6762586_18 membrane transporter protein K07090 - - 0.00000000000000000000001052 117.0
HFD2_k127_6762586_19 PFAM AIG2 family protein - - - 0.00000000000000000000001134 108.0
HFD2_k127_6762586_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 372.0
HFD2_k127_6762586_20 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000219 106.0
HFD2_k127_6762586_3 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 348.0
HFD2_k127_6762586_4 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 324.0
HFD2_k127_6762586_5 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005489 290.0
HFD2_k127_6762586_6 photosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003098 261.0
HFD2_k127_6762586_7 protein conserved in bacteria K09797 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001062 248.0
HFD2_k127_6762586_8 alpha beta - - - 0.000000000000000000000000000000000000000000000000000007043 207.0
HFD2_k127_6762586_9 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001168 179.0
HFD2_k127_6767286_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 527.0
HFD2_k127_6767286_1 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 464.0
HFD2_k127_6767286_10 SMART Immunoglobulin C2 type - - - 0.0000000007419 70.0
HFD2_k127_6767286_11 Cobalt transport protein K16785 - - 0.000000005164 69.0
HFD2_k127_6767286_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
HFD2_k127_6767286_3 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000003161 276.0
HFD2_k127_6767286_4 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003238 272.0
HFD2_k127_6767286_5 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001543 260.0
HFD2_k127_6767286_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000007655 181.0
HFD2_k127_6767286_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000002676 190.0
HFD2_k127_6767286_8 FlgD Ig-like domain K21449 - - 0.000000000000000000000000000000000000000000004579 177.0
HFD2_k127_6767286_9 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000006199 135.0
HFD2_k127_6800422_0 Insulinase (Peptidase family M16) K07263 - - 5.911e-279 886.0
HFD2_k127_6800422_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 7.237e-265 850.0
HFD2_k127_6800422_10 Glycosyltransferase family 20 K16055 - 2.4.1.15,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 467.0
HFD2_k127_6800422_11 Belongs to the glycosyl hydrolase 57 family K22451 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 443.0
HFD2_k127_6800422_12 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 412.0
HFD2_k127_6800422_13 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 415.0
HFD2_k127_6800422_14 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 400.0
HFD2_k127_6800422_15 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 372.0
HFD2_k127_6800422_16 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 381.0
HFD2_k127_6800422_17 Catalyzes the reversible oxidation of malate to oxaloacetate K00016,K00024 - 1.1.1.27,1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 361.0
HFD2_k127_6800422_18 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 363.0
HFD2_k127_6800422_19 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 350.0
HFD2_k127_6800422_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.686e-214 680.0
HFD2_k127_6800422_20 PFAM aminotransferase class I and II K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 371.0
HFD2_k127_6800422_21 Sigma-54 factor, core binding domain K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 354.0
HFD2_k127_6800422_22 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 338.0
HFD2_k127_6800422_23 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 345.0
HFD2_k127_6800422_24 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 325.0
HFD2_k127_6800422_25 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 316.0
HFD2_k127_6800422_26 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 323.0
HFD2_k127_6800422_27 Threonine/Serine exporter, ThrE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 313.0
HFD2_k127_6800422_28 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 287.0
HFD2_k127_6800422_29 Belongs to the SIS family. GutQ KpsF subfamily K01627,K03281,K06041 - 2.5.1.55,5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001948 292.0
HFD2_k127_6800422_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 592.0
HFD2_k127_6800422_30 Deoxynucleoside kinase K15518 - 2.7.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000006205 265.0
HFD2_k127_6800422_31 succinyl-diaminopimelate desuccinylase K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000169 269.0
HFD2_k127_6800422_32 alginic acid biosynthetic process K07218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004233 291.0
HFD2_k127_6800422_33 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004325 272.0
HFD2_k127_6800422_34 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001766 272.0
HFD2_k127_6800422_35 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000005607 253.0
HFD2_k127_6800422_36 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000001881 245.0
HFD2_k127_6800422_37 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003738 226.0
HFD2_k127_6800422_38 cellulase activity - - - 0.0000000000000000000000000000000000000000000000000000001979 225.0
HFD2_k127_6800422_39 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000292 206.0
HFD2_k127_6800422_4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 580.0
HFD2_k127_6800422_40 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000001607 219.0
HFD2_k127_6800422_41 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.00000000000000000000000000000000000000000000000001899 206.0
HFD2_k127_6800422_42 Hit family K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000001558 183.0
HFD2_k127_6800422_43 Histidine kinase HAMP - - - 0.0000000000000000000000000000000000000000000000003102 190.0
HFD2_k127_6800422_44 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000000005112 156.0
HFD2_k127_6800422_45 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000002801 164.0
HFD2_k127_6800422_46 Thioredoxin-like - - - 0.000000000000000000000000000000000002125 151.0
HFD2_k127_6800422_47 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000003491 135.0
HFD2_k127_6800422_48 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000001428 141.0
HFD2_k127_6800422_49 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000001979 135.0
HFD2_k127_6800422_5 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 569.0
HFD2_k127_6800422_50 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000001141 126.0
HFD2_k127_6800422_51 PTS system, mannose-specific IID component K02796 - - 0.000000000000000000000000000003501 129.0
HFD2_k127_6800422_52 succinate dehydrogenase K00241 - - 0.00000000000000000000000000003368 129.0
HFD2_k127_6800422_53 YceI-like domain - - - 0.000000000000000000000000003688 132.0
HFD2_k127_6800422_54 PIN domain K07064 GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007 - 0.000000000000000000000004882 113.0
HFD2_k127_6800422_55 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000001886 107.0
HFD2_k127_6800422_56 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000001532 106.0
HFD2_k127_6800422_57 PTS system sorbose subfamily IIB component K19507 - - 0.00000000000000000001117 98.0
HFD2_k127_6800422_58 Belongs to the GcvT family K00605,K06980 - 2.1.2.10 0.00000000000000000001995 102.0
HFD2_k127_6800422_59 PFAM Glycosyl transferase family 4 K02851,K13007 - 2.7.8.33,2.7.8.35 0.0000000000000002474 94.0
HFD2_k127_6800422_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 551.0
HFD2_k127_6800422_60 Lipopolysaccharide-assembly, LptC-related - - - 0.0000000000009182 77.0
HFD2_k127_6800422_61 PEP-CTERM motif - - - 0.000000000001379 77.0
HFD2_k127_6800422_62 transferase activity, transferring glycosyl groups - - - 0.000000000004001 81.0
HFD2_k127_6800422_63 Belongs to the eIF-2B alpha beta delta subunits family - - - 0.000000000008878 78.0
HFD2_k127_6800422_64 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000001098 79.0
HFD2_k127_6800422_65 Protein of unknown function (DUF2723) - - - 0.00000000004301 76.0
HFD2_k127_6800422_66 self proteolysis K04771 - 3.4.21.107 0.0000000002265 75.0
HFD2_k127_6800422_67 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000003016 65.0
HFD2_k127_6800422_68 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000008987 62.0
HFD2_k127_6800422_69 Tetratricopeptide TPR_2 repeat protein - - - 0.00000001035 69.0
HFD2_k127_6800422_7 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 534.0
HFD2_k127_6800422_70 regulation of translation K05808,K05809 GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.00000001764 61.0
HFD2_k127_6800422_71 PFAM Cell envelope-related transcriptional attenuator domain - - - 0.00000006689 60.0
HFD2_k127_6800422_72 Protein of unknown function (DUF664) - - - 0.0000005313 61.0
HFD2_k127_6800422_73 Tetratricopeptide TPR_2 repeat protein - - - 0.000027 57.0
HFD2_k127_6800422_74 PTS system sorbose-specific iic component K02795,K19508 - - 0.00008333 56.0
HFD2_k127_6800422_75 PTS system, mannose fructose sorbose family, IIA subunit K02793 - 2.7.1.191 0.0001261 55.0
HFD2_k127_6800422_76 PFAM Conserved TM helix - - - 0.0001486 52.0
HFD2_k127_6800422_78 cellulose binding - - - 0.0004851 54.0
HFD2_k127_6800422_8 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 506.0
HFD2_k127_6800422_9 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006027 477.0
HFD2_k127_6838844_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1122.0
HFD2_k127_6838844_1 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002555 255.0
HFD2_k127_6838844_2 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002884 269.0
HFD2_k127_6838844_3 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000001346 211.0
HFD2_k127_6838844_4 PFAM Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000005108 173.0
HFD2_k127_6838844_5 - - - - 0.00000000006288 76.0
HFD2_k127_6838844_6 COG3209 Rhs family protein - - - 0.000000001407 71.0
HFD2_k127_6838844_7 - - - - 0.0000001009 53.0
HFD2_k127_6987963_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.329e-200 638.0
HFD2_k127_6987963_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 507.0
HFD2_k127_6987963_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 389.0
HFD2_k127_6987963_3 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002154 248.0
HFD2_k127_6987963_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000007233 246.0
HFD2_k127_6987963_5 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000007199 241.0
HFD2_k127_6987963_6 PFAM Kelch motif - - - 0.00000000001711 73.0
HFD2_k127_6987963_7 Methyl-accepting chemotaxis protein (MCP) signaling domain K03406 - - 0.0000002339 64.0
HFD2_k127_6987963_8 repeat protein - - - 0.00004177 57.0
HFD2_k127_7112675_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000001008 248.0
HFD2_k127_7112675_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000003698 117.0
HFD2_k127_7131678_0 Ribosomal protein S1 K02945,K03527,K12132 GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 3.493e-225 723.0
HFD2_k127_7131678_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.457e-204 681.0
HFD2_k127_7131678_10 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 359.0
HFD2_k127_7131678_11 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 347.0
HFD2_k127_7131678_12 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009201 351.0
HFD2_k127_7131678_13 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 319.0
HFD2_k127_7131678_14 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 301.0
HFD2_k127_7131678_15 COG601 ABC-type dipeptide oligopeptide nickel transport systems, permease components Amino acid transport and metabolism Inorganic ion transport and metabolism K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 308.0
HFD2_k127_7131678_16 aminopeptidase activity K07004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000729 310.0
HFD2_k127_7131678_17 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003401 287.0
HFD2_k127_7131678_18 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005024 299.0
HFD2_k127_7131678_19 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006124 300.0
HFD2_k127_7131678_2 Methylenetetrahydrofolate reductase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 612.0
HFD2_k127_7131678_20 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000002141 257.0
HFD2_k127_7131678_21 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - 0.00000000000000000000000000000000000000000000000000000000000000000004911 254.0
HFD2_k127_7131678_22 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000005994 231.0
HFD2_k127_7131678_23 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000001105 227.0
HFD2_k127_7131678_24 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000002224 218.0
HFD2_k127_7131678_25 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000001355 216.0
HFD2_k127_7131678_26 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000746 215.0
HFD2_k127_7131678_27 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000000000000001813 194.0
HFD2_k127_7131678_28 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000001152 198.0
HFD2_k127_7131678_29 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000001909 193.0
HFD2_k127_7131678_3 Aminotransferase class-III K03918,K07250,K20428 - 2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007813 514.0
HFD2_k127_7131678_30 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000005665 174.0
HFD2_k127_7131678_31 - - - - 0.00000000000000000000000000000000000000000000006553 177.0
HFD2_k127_7131678_32 glycosyl transferase - - - 0.0000000000000000000000000000000000002758 153.0
HFD2_k127_7131678_33 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000004154 151.0
HFD2_k127_7131678_34 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000003274 137.0
HFD2_k127_7131678_35 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000003749 145.0
HFD2_k127_7131678_36 BMC K04027 - - 0.000000000000000000000000000000009968 129.0
HFD2_k127_7131678_37 propanediol utilization protein - - - 0.00000000000000000000000000000001624 146.0
HFD2_k127_7131678_38 lysyltransferase activity K07027 - - 0.0000000000000000000000000000002937 144.0
HFD2_k127_7131678_39 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.00000000000000000000000000005278 127.0
HFD2_k127_7131678_4 Aldehyde dehydrogenase family K04021,K13922 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 492.0
HFD2_k127_7131678_40 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.0000000000000000000000002315 124.0
HFD2_k127_7131678_41 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530,K05788 - - 0.0000000000000000000000007581 109.0
HFD2_k127_7131678_42 EamA-like transporter family - - - 0.0000000000000000000000009269 115.0
HFD2_k127_7131678_43 regulatory protein, MerR - - - 0.00000000000000000003194 96.0
HFD2_k127_7131678_44 Ethanolamine utilisation protein EutN/carboxysome K04028 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.00000000000000000005586 97.0
HFD2_k127_7131678_45 Ethanolamine utilization protein EutN K04028 - - 0.0000000000000000000669 95.0
HFD2_k127_7131678_46 Domain of unknown function (DUF296) K06934 - - 0.000000000000000000215 104.0
HFD2_k127_7131678_47 Bacterial lipid A biosynthesis acyltransferase K02517,K22311 - 2.3.1.241,2.3.1.265 0.000000000000000000379 98.0
HFD2_k127_7131678_48 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000003064 92.0
HFD2_k127_7131678_49 BMC K04027 - - 0.000000000000000005738 87.0
HFD2_k127_7131678_5 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 460.0
HFD2_k127_7131678_50 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000001717 81.0
HFD2_k127_7131678_51 PFAM transposase IS3 IS911 family protein K07497 - - 0.0000000000000221 74.0
HFD2_k127_7131678_52 Ethanolamine utilisation protein EutN/carboxysome - - - 0.000000000006591 76.0
HFD2_k127_7131678_53 antisigma factor binding K04749 - - 0.00000003376 61.0
HFD2_k127_7131678_54 Regulatory protein, FmdB family - - - 0.0000002353 59.0
HFD2_k127_7131678_56 peptidyl-tyrosine sulfation - - - 0.000002495 62.0
HFD2_k127_7131678_58 - - - - 0.00008467 50.0
HFD2_k127_7131678_6 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 424.0
HFD2_k127_7131678_7 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 385.0
HFD2_k127_7131678_8 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 358.0
HFD2_k127_7131678_9 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 361.0
HFD2_k127_7163130_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1266.0
HFD2_k127_7163130_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 509.0
HFD2_k127_7163130_10 oligosaccharyl transferase activity - - - 0.00000000000000000000004405 115.0
HFD2_k127_7163130_11 amine dehydrogenase activity - - - 0.00000000001647 76.0
HFD2_k127_7163130_12 Lipopolysaccharide-assembly - - - 0.0000005482 58.0
HFD2_k127_7163130_13 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.000003144 59.0
HFD2_k127_7163130_2 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 429.0
HFD2_k127_7163130_3 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 423.0
HFD2_k127_7163130_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 356.0
HFD2_k127_7163130_5 Hexapeptide repeat of succinyl-transferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 303.0
HFD2_k127_7163130_6 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000001275 221.0
HFD2_k127_7163130_7 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000002545 199.0
HFD2_k127_7163130_8 Sensor diguanylate cyclase, GAF domain-containing - - - 0.0000000000000000000000000000000000000000000001887 181.0
HFD2_k127_7163130_9 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000016 153.0
HFD2_k127_7288840_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.972e-280 884.0
HFD2_k127_7288840_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 407.0
HFD2_k127_7288840_2 Aminotransferase class-V - GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 342.0
HFD2_k127_7288840_3 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00015,K00058,K16843 - 1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000049 287.0
HFD2_k127_7288840_4 - - - - 0.0000000000005034 71.0
HFD2_k127_730966_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.692e-214 683.0
HFD2_k127_730966_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.983e-209 667.0
HFD2_k127_730966_10 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 359.0
HFD2_k127_730966_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 353.0
HFD2_k127_730966_12 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 350.0
HFD2_k127_730966_13 Phospholipase D. Active site motifs. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 331.0
HFD2_k127_730966_14 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 317.0
HFD2_k127_730966_15 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 316.0
HFD2_k127_730966_16 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 289.0
HFD2_k127_730966_17 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000007612 262.0
HFD2_k127_730966_18 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000001272 253.0
HFD2_k127_730966_19 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000006004 229.0
HFD2_k127_730966_2 Pyridoxal-phosphate dependent enzyme - - - 5.318e-207 657.0
HFD2_k127_730966_20 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767 - 0.00000000000000000000000000000000000000000000000000000000505 205.0
HFD2_k127_730966_21 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.00000000000000000000000000000000000000000000000007649 193.0
HFD2_k127_730966_22 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000006336 143.0
HFD2_k127_730966_23 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000007153 158.0
HFD2_k127_730966_24 Acid phosphatase vanadium-dependent haloperoxidase related K09775 - - 0.00000000000000000000000000000000008439 138.0
HFD2_k127_730966_25 RDD family - - - 0.000000000000000000000000000000004024 136.0
HFD2_k127_730966_26 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000003488 121.0
HFD2_k127_730966_27 TM2 domain - - - 0.0000000000000000000001081 114.0
HFD2_k127_730966_28 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000002863 85.0
HFD2_k127_730966_29 - - - - 0.0000000000002428 80.0
HFD2_k127_730966_3 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 602.0
HFD2_k127_730966_30 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000006689 60.0
HFD2_k127_730966_31 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000708 60.0
HFD2_k127_730966_32 Protein of unknown function (DUF664) - - - 0.00001194 55.0
HFD2_k127_730966_33 Sulfotransferase family - - - 0.0000462 57.0
HFD2_k127_730966_4 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 554.0
HFD2_k127_730966_5 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 511.0
HFD2_k127_730966_6 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 505.0
HFD2_k127_730966_7 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 433.0
HFD2_k127_730966_8 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006183 390.0
HFD2_k127_730966_9 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 396.0
HFD2_k127_7360323_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1263.0
HFD2_k127_7360323_1 PFAM Glycosyl transferase family 2 - - - 6.825e-297 935.0
HFD2_k127_7360323_10 D12 class N6 adenine-specific DNA methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 411.0
HFD2_k127_7360323_11 3-beta hydroxysteroid dehydrogenase/isomerase family K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 379.0
HFD2_k127_7360323_12 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 389.0
HFD2_k127_7360323_13 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 335.0
HFD2_k127_7360323_14 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002955 226.0
HFD2_k127_7360323_15 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000007991 204.0
HFD2_k127_7360323_16 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000005637 209.0
HFD2_k127_7360323_17 endonuclease activity K07451 - - 0.00000000000000000000000000000000000000000000000002923 197.0
HFD2_k127_7360323_18 regulator of chromosome condensation, RCC1 - - - 0.0000000000000000000000000000000000000000000003316 194.0
HFD2_k127_7360323_19 Outer membrane protein beta-barrel family K16087,K16092 - - 0.000000000000000000000000000000000000000000000565 190.0
HFD2_k127_7360323_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 7.665e-241 775.0
HFD2_k127_7360323_21 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000000000004404 166.0
HFD2_k127_7360323_22 Phospholipid methyltransferase - - - 0.000000000000000000000000000000004306 137.0
HFD2_k127_7360323_23 Transposase (IS116 IS110 IS902 family) - - - 0.0000000000000000000000003082 118.0
HFD2_k127_7360323_24 Phosphotransferase enzyme family - - - 0.000000171 63.0
HFD2_k127_7360323_25 Protein of unknown function (DUF2723) K14340 - - 0.0000002096 64.0
HFD2_k127_7360323_26 fatty-acyl-CoA reductase (alcohol-forming) activity K01007,K18845 - 2.1.1.179,2.7.9.2 0.0000008393 62.0
HFD2_k127_7360323_27 Exodeoxyribonuclease III - - - 0.00002103 58.0
HFD2_k127_7360323_28 Phosphotransferase enzyme family - - - 0.000297 54.0
HFD2_k127_7360323_3 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 2.392e-239 761.0
HFD2_k127_7360323_4 lysine biosynthetic process via aminoadipic acid - - - 2.77e-217 705.0
HFD2_k127_7360323_5 Doubled CXXCH motif (Paired_CXXCH_1) - - - 7.65e-203 667.0
HFD2_k127_7360323_6 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 607.0
HFD2_k127_7360323_7 ABC-type multidrug transport system ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005975 607.0
HFD2_k127_7360323_8 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 551.0
HFD2_k127_7360323_9 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 427.0
HFD2_k127_7389023_0 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 399.0
HFD2_k127_7389023_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001263 283.0
HFD2_k127_7389023_2 thymidine kinase activity K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000001653 237.0
HFD2_k127_7389023_3 transposition, DNA-mediated K02342 - 2.7.7.7 0.00000000000000000000000000000000304 141.0
HFD2_k127_7444701_0 Glycosyl hydrolase family 92 - - - 1.501e-279 894.0
HFD2_k127_7444701_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 7.661e-250 792.0
HFD2_k127_7444701_10 cytochrome C peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 481.0
HFD2_k127_7444701_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 477.0
HFD2_k127_7444701_12 Belongs to the binding-protein-dependent transport system permease family K10544,K10547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 440.0
HFD2_k127_7444701_13 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 421.0
HFD2_k127_7444701_14 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 406.0
HFD2_k127_7444701_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 416.0
HFD2_k127_7444701_16 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 415.0
HFD2_k127_7444701_17 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 404.0
HFD2_k127_7444701_18 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 411.0
HFD2_k127_7444701_19 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 404.0
HFD2_k127_7444701_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 9.362e-239 765.0
HFD2_k127_7444701_20 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 368.0
HFD2_k127_7444701_21 TIGRFAM phosphate ABC transporter, phosphate-binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 370.0
HFD2_k127_7444701_22 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 339.0
HFD2_k127_7444701_23 inorganic phosphate transmembrane transporter activity K02037,K02038 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 327.0
HFD2_k127_7444701_24 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008247 325.0
HFD2_k127_7444701_25 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 332.0
HFD2_k127_7444701_26 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 315.0
HFD2_k127_7444701_27 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 304.0
HFD2_k127_7444701_28 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 302.0
HFD2_k127_7444701_29 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 288.0
HFD2_k127_7444701_3 Amino acid permease - - - 3.34e-198 638.0
HFD2_k127_7444701_30 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000004178 273.0
HFD2_k127_7444701_31 chlorophyll binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000005293 256.0
HFD2_k127_7444701_32 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000007014 241.0
HFD2_k127_7444701_33 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000181 261.0
HFD2_k127_7444701_34 PFAM PEBP family protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000000000532 239.0
HFD2_k127_7444701_35 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000000000000000000000000000000000000000000006603 238.0
HFD2_k127_7444701_36 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000006046 231.0
HFD2_k127_7444701_37 PhoQ Sensor K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000001028 235.0
HFD2_k127_7444701_38 Glycosyltransferase like family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000004612 231.0
HFD2_k127_7444701_39 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000008291 221.0
HFD2_k127_7444701_4 purine nucleobase transmembrane transporter activity K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 592.0
HFD2_k127_7444701_40 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000009201 213.0
HFD2_k127_7444701_41 endonuclease activity K07451 - - 0.0000000000000000000000000000000000000000000000001201 191.0
HFD2_k127_7444701_42 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.000000000000000000000000000000000000000000000000585 191.0
HFD2_k127_7444701_43 Multi-sensor signal transduction histidine kinase K07710 - 2.7.13.3 0.0000000000000000000000000000000000000000000004617 192.0
HFD2_k127_7444701_44 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000009835 176.0
HFD2_k127_7444701_45 TIGRFAM glycogen debranching enzyme - - - 0.000000000000000000000000000000000000000000339 181.0
HFD2_k127_7444701_46 Sterol carrier protein domain - - - 0.00000000000000000000000000000000000000001499 172.0
HFD2_k127_7444701_47 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000976 161.0
HFD2_k127_7444701_48 PAS domain - - - 0.00000000000000000000000000000000000000292 166.0
HFD2_k127_7444701_49 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000004265 147.0
HFD2_k127_7444701_5 ABC transporter K02056,K05776,K10441,K10542,K10545,K10548 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 571.0
HFD2_k127_7444701_50 Nitroreductase - - - 0.0000000000000000000000000000000001624 147.0
HFD2_k127_7444701_51 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000003473 147.0
HFD2_k127_7444701_52 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000005558 142.0
HFD2_k127_7444701_53 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.00000000000000000000000000000007577 134.0
HFD2_k127_7444701_54 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000002149 139.0
HFD2_k127_7444701_55 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000007628 135.0
HFD2_k127_7444701_56 Divergent polysaccharide deacetylase K09798 - - 0.000000000000000000000002914 118.0
HFD2_k127_7444701_57 Phospholipid methyltransferase - - - 0.00000000000000000000001267 115.0
HFD2_k127_7444701_58 TIGRFAM acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000000000000000001446 106.0
HFD2_k127_7444701_6 Glycosyl hydrolase family 47 K01230 - 3.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 526.0
HFD2_k127_7444701_60 Cytochrome c - - - 0.000000000000000000005942 97.0
HFD2_k127_7444701_61 acetyltransferase K06976 - - 0.0000000000000000001367 98.0
HFD2_k127_7444701_62 Tetratricopeptide repeat - - - 0.00000000000001818 89.0
HFD2_k127_7444701_63 Mut7-C RNAse domain K09122 - - 0.0000000000002306 83.0
HFD2_k127_7444701_65 AsmA-like C-terminal region - - - 0.00000000003833 77.0
HFD2_k127_7444701_66 - - - - 0.0000000002382 69.0
HFD2_k127_7444701_67 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000884 66.0
HFD2_k127_7444701_68 - - - - 0.000000004077 70.0
HFD2_k127_7444701_69 - - - - 0.00000001544 65.0
HFD2_k127_7444701_7 Uncharacterized protein conserved in bacteria (DUF2330) K00347,K21163 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 522.0
HFD2_k127_7444701_70 NQR2, RnfD, RnfE family - - - 0.00000001761 66.0
HFD2_k127_7444701_71 Dioxygenase - - - 0.00000002042 65.0
HFD2_k127_7444701_72 Aspartyl protease - - - 0.00000002043 67.0
HFD2_k127_7444701_73 Periplasmic or secreted lipoprotein - - - 0.00000003215 63.0
HFD2_k127_7444701_74 HEAT repeats - - - 0.0000002666 63.0
HFD2_k127_7444701_75 nucleotide catabolic process K05996 - 3.4.17.18 0.0000004967 61.0
HFD2_k127_7444701_76 - - - - 0.000007443 59.0
HFD2_k127_7444701_77 O-antigen ligase like membrane protein K02847 - - 0.0000137 58.0
HFD2_k127_7444701_78 Membrane - - - 0.00003575 53.0
HFD2_k127_7444701_79 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.00006954 56.0
HFD2_k127_7444701_8 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 497.0
HFD2_k127_7444701_80 haloacid dehalogenase-like hydrolase K17686 - 3.6.3.54 0.0003699 53.0
HFD2_k127_7444701_9 Periplasmic binding protein domain K10543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 461.0
HFD2_k127_7509659_0 Tricorn protease homolog - - - 0.0 1309.0
HFD2_k127_7509659_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.344e-270 856.0
HFD2_k127_7509659_10 Cytochrome b/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 300.0
HFD2_k127_7509659_11 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 305.0
HFD2_k127_7509659_12 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 309.0
HFD2_k127_7509659_13 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 297.0
HFD2_k127_7509659_14 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002097 289.0
HFD2_k127_7509659_15 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000005852 243.0
HFD2_k127_7509659_16 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001198 231.0
HFD2_k127_7509659_17 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000001037 198.0
HFD2_k127_7509659_18 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000000000000000000000000001987 156.0
HFD2_k127_7509659_19 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000002043 161.0
HFD2_k127_7509659_2 Cleaves the N-terminal amino acid of tripeptides K01258 - 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 502.0
HFD2_k127_7509659_20 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms - - - 0.0000000000000000000000000000000000004846 154.0
HFD2_k127_7509659_21 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000003063 135.0
HFD2_k127_7509659_22 DinB superfamily - - - 0.000000000000000000000000000000002006 137.0
HFD2_k127_7509659_23 iron ion binding - - - 0.00000000000000000000000002391 117.0
HFD2_k127_7509659_24 COG0463, glycosyltransferases involved in cell wall biogenesis - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000409 120.0
HFD2_k127_7509659_25 domain, Protein K02519,K03832 - - 0.00000000000000003317 96.0
HFD2_k127_7509659_26 Forkhead associated domain - - - 0.00000000000007934 83.0
HFD2_k127_7509659_27 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000001912 84.0
HFD2_k127_7509659_28 Rubrerythrin - - - 0.000000000385 70.0
HFD2_k127_7509659_29 Tetratricopeptide TPR_2 repeat protein - - - 0.00000001079 64.0
HFD2_k127_7509659_3 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 514.0
HFD2_k127_7509659_30 peptidyl-tyrosine sulfation - - - 0.0006114 53.0
HFD2_k127_7509659_4 Lipase maturation factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 495.0
HFD2_k127_7509659_5 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008587 474.0
HFD2_k127_7509659_6 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 447.0
HFD2_k127_7509659_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 422.0
HFD2_k127_7509659_8 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009953 402.0
HFD2_k127_7509659_9 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 387.0
HFD2_k127_76249_0 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007932 479.0
HFD2_k127_76249_1 NAD(P)H-binding K01784,K02473 - 5.1.3.2,5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 397.0
HFD2_k127_76249_2 Glycosyl transferase 4-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 383.0
HFD2_k127_76249_3 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 361.0
HFD2_k127_76249_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000008825 225.0
HFD2_k127_76249_5 Pfam Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000002011 198.0
HFD2_k127_76249_6 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000006828 186.0
HFD2_k127_76249_7 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000004511 152.0
HFD2_k127_76249_8 extracellular polysaccharide biosynthetic process K01153,K05789,K07011,K16554 - 3.1.21.3 0.0000000000000000000000000000000002602 146.0
HFD2_k127_76249_9 O-Antigen ligase - - - 0.0001376 54.0
HFD2_k127_7705259_0 Cytochrome b subunit of formate dehydrogenase-like protein - GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016002,GO:0016043,GO:0016491,GO:0016667,GO:0017144,GO:0019748,GO:0020037,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044550,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051259,GO:0051260,GO:0055114,GO:0065003,GO:0070206,GO:0070207,GO:0070813,GO:0070814,GO:0071840,GO:0097159,GO:1901363,GO:1903136 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 556.0
HFD2_k127_7705259_1 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007236 443.0
HFD2_k127_7705259_10 photosystem II stabilization K02237 - - 0.000000000000000000000000000000000000000002728 173.0
HFD2_k127_7705259_11 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000001539 159.0
HFD2_k127_7705259_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000005064 141.0
HFD2_k127_7705259_13 Metallo-beta-lactamase superfamily K02238 - - 0.000000000000000000000000000002649 136.0
HFD2_k127_7705259_14 Adagio protein K12115,K12117 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464 - 0.000000000000000008996 99.0
HFD2_k127_7705259_15 long-chain fatty acid transport protein K06076 - - 0.00000000000000008772 93.0
HFD2_k127_7705259_16 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000002564 93.0
HFD2_k127_7705259_17 - K01083 - 3.1.3.8 0.00000000000000299 91.0
HFD2_k127_7705259_18 response regulator, receiver K07776 - - 0.0000005755 58.0
HFD2_k127_7705259_19 Protein of unknown function (DUF2892) - - - 0.000001405 55.0
HFD2_k127_7705259_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005239 410.0
HFD2_k127_7705259_3 COGs COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 393.0
HFD2_k127_7705259_4 Helix-hairpin-helix motif K02237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 411.0
HFD2_k127_7705259_5 Belongs to the 5'-nucleotidase family K01081,K11751,K17224 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 381.0
HFD2_k127_7705259_6 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001643 306.0
HFD2_k127_7705259_7 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000007124 268.0
HFD2_k127_7705259_8 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000008785 205.0
HFD2_k127_7705259_9 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.00000000000000000000000000000000000000000000251 168.0
HFD2_k127_8034280_0 Transglycosylase K05366 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 618.0
HFD2_k127_8034280_1 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 497.0
HFD2_k127_8034280_10 PFAM MazG nucleotide pyrophosphohydrolase K02499,K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000008287 232.0
HFD2_k127_8034280_11 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000001133 186.0
HFD2_k127_8034280_12 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000007067 135.0
HFD2_k127_8034280_13 - - - - 0.000000000000000000000000000008758 121.0
HFD2_k127_8034280_15 - - - - 0.0000000000000008445 79.0
HFD2_k127_8034280_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 428.0
HFD2_k127_8034280_3 Pyrimidine nucleoside phosphorylase C-terminal domain K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008839 405.0
HFD2_k127_8034280_4 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 368.0
HFD2_k127_8034280_5 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 367.0
HFD2_k127_8034280_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 328.0
HFD2_k127_8034280_7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 305.0
HFD2_k127_8034280_8 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002762 275.0
HFD2_k127_8034280_9 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002378 273.0
HFD2_k127_8056050_0 peptidase K07386 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 565.0
HFD2_k127_8056050_1 Major facilitator Superfamily K08162,K08226,K16211 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 486.0
HFD2_k127_8056050_10 Outer membrane protein beta-barrel domain - - - 0.000525 51.0
HFD2_k127_8056050_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000098 458.0
HFD2_k127_8056050_3 RecQ zinc-binding K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 455.0
HFD2_k127_8056050_4 Mitochondrial biogenesis AIM24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 426.0
HFD2_k127_8056050_5 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000955 391.0
HFD2_k127_8056050_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000002159 218.0
HFD2_k127_8056050_7 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000004724 129.0
HFD2_k127_8056050_8 lyase activity - - - 0.0000000000000000000000006242 121.0
HFD2_k127_8056050_9 - K01286 - 3.4.16.4 0.0000000000000000000006972 106.0
HFD2_k127_8093447_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K03520 - 1.2.5.3 0.0 1114.0
HFD2_k127_8093447_1 Tricorn protease homolog K08676 - - 6.498e-296 947.0
HFD2_k127_8093447_10 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 373.0
HFD2_k127_8093447_11 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 334.0
HFD2_k127_8093447_12 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 306.0
HFD2_k127_8093447_13 Belongs to the ATCase OTCase family - GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 299.0
HFD2_k127_8093447_14 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000706 253.0
HFD2_k127_8093447_15 LysM domain - - - 0.00000000000000000000000000000000000000000000000000001494 197.0
HFD2_k127_8093447_16 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000009377 185.0
HFD2_k127_8093447_17 - - - - 0.00000000000000000000000000000000000003979 166.0
HFD2_k127_8093447_18 - - - - 0.0000000000000000000000000000000000003777 146.0
HFD2_k127_8093447_19 Penicillinase repressor - - - 0.00000000000000000000000000000002434 130.0
HFD2_k127_8093447_2 Sigma-54 interaction domain - - - 9.479e-197 637.0
HFD2_k127_8093447_20 - - - - 0.0000000000000000000000000000000438 146.0
HFD2_k127_8093447_21 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000007818 138.0
HFD2_k127_8093447_22 - - - - 0.0000000000000000000000000000116 122.0
HFD2_k127_8093447_23 - - - - 0.0000000000000000000000007581 109.0
HFD2_k127_8093447_24 endonuclease activity K07451 - - 0.00000000000000000000007458 109.0
HFD2_k127_8093447_25 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000003561 96.0
HFD2_k127_8093447_26 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000005132 96.0
HFD2_k127_8093447_27 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.000000007808 61.0
HFD2_k127_8093447_28 Domain of unknown function (DUF4920) - - - 0.000003511 61.0
HFD2_k127_8093447_3 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 610.0
HFD2_k127_8093447_30 Evidence 5 No homology to any previously reported sequences - - - 0.00001363 56.0
HFD2_k127_8093447_31 Sortilin, neurotensin receptor 3, - - - 0.00003149 56.0
HFD2_k127_8093447_32 - - - - 0.0002609 48.0
HFD2_k127_8093447_33 Tetratricopeptide repeat - - - 0.0009591 53.0
HFD2_k127_8093447_4 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 520.0
HFD2_k127_8093447_6 dihydroorotate dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 458.0
HFD2_k127_8093447_7 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 428.0
HFD2_k127_8093447_8 domain protein K02674,K07004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 393.0
HFD2_k127_8093447_9 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 379.0
HFD2_k127_8111922_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 6.302e-298 951.0
HFD2_k127_8111922_1 Sugar (and other) transporter K07058 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 590.0
HFD2_k127_8111922_10 FlgD Ig-like domain - - - 0.000000000000000000002058 110.0
HFD2_k127_8111922_12 alginic acid biosynthetic process K01729,K12287 - 4.2.2.3 0.00000000004934 76.0
HFD2_k127_8111922_13 membrane - - - 0.00000000006597 76.0
HFD2_k127_8111922_14 LVIVD repeat K01179 - 3.2.1.4 0.0000001422 54.0
HFD2_k127_8111922_2 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 503.0
HFD2_k127_8111922_3 Multicopper oxidase K06324 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 492.0
HFD2_k127_8111922_4 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000066 379.0
HFD2_k127_8111922_5 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 348.0
HFD2_k127_8111922_6 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 336.0
HFD2_k127_8111922_7 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006484 293.0
HFD2_k127_8111922_8 TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000001155 263.0
HFD2_k127_8111922_9 PFAM FAD linked oxidase domain protein K00104,K11472 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 0.0000000000000000000000000000000000006272 161.0
HFD2_k127_8157019_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 2.306e-312 975.0
HFD2_k127_8157019_1 TIGRFAM methylmalonyl-CoA mutase N-terminal domain K01848 - 5.4.99.2 3.507e-224 712.0
HFD2_k127_8157019_10 PFAM 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 372.0
HFD2_k127_8157019_11 undecaprenyl-phosphate glucose phosphotransferase activity K03606,K20997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 359.0
HFD2_k127_8157019_12 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 329.0
HFD2_k127_8157019_13 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 327.0
HFD2_k127_8157019_14 ArgK protein K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000985 290.0
HFD2_k127_8157019_15 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000006834 265.0
HFD2_k127_8157019_16 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.000000000000000000000000000000000000000000000000000000000000000000000002299 256.0
HFD2_k127_8157019_17 Monogalactosyldiacylglycerol (MGDG) synthase K03429 - 2.4.1.315 0.000000000000000000000000000000000000000000000000000000000000000000000009314 261.0
HFD2_k127_8157019_18 FIST C domain - GO:0008150,GO:0040007 - 0.00000000000000000000000000000000000000000000000000000000000000000000002308 258.0
HFD2_k127_8157019_19 Protein conserved in bacteria K06320 - - 0.00000000000000000000000000000000000000000000000000000000000000000002627 254.0
HFD2_k127_8157019_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008871 493.0
HFD2_k127_8157019_20 SdpI/YhfL protein family - - - 0.000000000000000000000000000000000000000000000000000000000000005523 232.0
HFD2_k127_8157019_21 WxcM-like, C-terminal K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000005381 215.0
HFD2_k127_8157019_22 - - - - 0.0000000000000000000000000000000000000000000000000000000001253 214.0
HFD2_k127_8157019_23 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000002111 207.0
HFD2_k127_8157019_24 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000008682 192.0
HFD2_k127_8157019_25 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000367 196.0
HFD2_k127_8157019_26 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000005438 177.0
HFD2_k127_8157019_27 polysaccharide export K01991 - - 0.00000000000000000000000000000000000000000004714 184.0
HFD2_k127_8157019_28 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000001716 176.0
HFD2_k127_8157019_29 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000000000000003421 150.0
HFD2_k127_8157019_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006826 469.0
HFD2_k127_8157019_30 Haem-binding domain - - - 0.000000000000000000000000000000000000002912 154.0
HFD2_k127_8157019_31 3-demethylubiquinone-9 3-O-methyltransferase activity K18827 - 2.1.1.294,2.7.1.181 0.00000000000000000000000000000000000001214 166.0
HFD2_k127_8157019_32 PFAM glycosyl transferase family 2 K20444 - - 0.0000000000000000000000000000000000001159 154.0
HFD2_k127_8157019_33 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000001305 138.0
HFD2_k127_8157019_34 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000004267 146.0
HFD2_k127_8157019_35 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000003324 129.0
HFD2_k127_8157019_36 regulatory protein, arsR - - - 0.0000000000000000000000001195 108.0
HFD2_k127_8157019_37 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000002638 119.0
HFD2_k127_8157019_38 amine oxidase - - - 0.0000000000000000000000004332 123.0
HFD2_k127_8157019_39 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.0000000000000000000001778 104.0
HFD2_k127_8157019_4 Acyl-CoA dehydrogenase, N-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 435.0
HFD2_k127_8157019_40 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000001348 99.0
HFD2_k127_8157019_42 Pfam Methyltransferase - - - 0.000000000000003262 87.0
HFD2_k127_8157019_43 PFAM Glycosyl transferase, group 1 K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.0000000000001259 84.0
HFD2_k127_8157019_44 O-Antigen ligase - - - 0.000000000002145 81.0
HFD2_k127_8157019_45 Belongs to the UPF0109 family K06960 - - 0.000000000016 73.0
HFD2_k127_8157019_46 - - - - 0.00000000003561 72.0
HFD2_k127_8157019_47 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.00000000006573 68.0
HFD2_k127_8157019_48 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000001235 74.0
HFD2_k127_8157019_49 Periplasmic component of the Tol biopolymer transport system K03641 - - 0.0000000003193 74.0
HFD2_k127_8157019_5 acyl-CoA dehydrogenase K00248,K22430 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108,1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 435.0
HFD2_k127_8157019_50 oligosaccharyl transferase activity - - - 0.000000007852 69.0
HFD2_k127_8157019_51 Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA) K03328,K16693 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000007442 58.0
HFD2_k127_8157019_52 - - - - 0.0006419 52.0
HFD2_k127_8157019_53 Tetratricopeptide TPR_2 repeat protein - - - 0.0008064 52.0
HFD2_k127_8157019_6 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 410.0
HFD2_k127_8157019_7 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46,4.2.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 385.0
HFD2_k127_8157019_8 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 382.0
HFD2_k127_8157019_9 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 368.0
HFD2_k127_817450_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 2.415e-297 928.0
HFD2_k127_817450_1 lysine biosynthetic process via aminoadipic acid - - - 9.601e-248 796.0
HFD2_k127_817450_10 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005821 349.0
HFD2_k127_817450_11 Cellulose biosynthesis protein BcsQ K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 324.0
HFD2_k127_817450_12 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006428 293.0
HFD2_k127_817450_13 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003899 293.0
HFD2_k127_817450_14 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000004397 294.0
HFD2_k127_817450_15 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000001402 248.0
HFD2_k127_817450_16 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000002033 257.0
HFD2_k127_817450_17 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000001749 241.0
HFD2_k127_817450_18 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000259 248.0
HFD2_k127_817450_19 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000004843 228.0
HFD2_k127_817450_2 lysine biosynthetic process via aminoadipic acid - - - 6.853e-243 779.0
HFD2_k127_817450_20 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001019 233.0
HFD2_k127_817450_21 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000001061 241.0
HFD2_k127_817450_22 GAF domain - - - 0.00000000000000000000000000000000000000000000000001096 199.0
HFD2_k127_817450_23 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors - - - 0.00000000000000000000000000000000000000000000000002503 207.0
HFD2_k127_817450_24 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000001631 190.0
HFD2_k127_817450_25 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000001658 197.0
HFD2_k127_817450_26 PFAM peptidase K16922 - - 0.00000000000000000000000000000000000000000000003616 194.0
HFD2_k127_817450_27 COGs COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000763 183.0
HFD2_k127_817450_28 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000005899 173.0
HFD2_k127_817450_29 - - - - 0.00000000000000000000000000000000000000000007424 172.0
HFD2_k127_817450_3 WD40 domain protein beta Propeller K12132 - 2.7.11.1 2.655e-238 766.0
HFD2_k127_817450_30 PFAM EamA-like transporter family - - - 0.000000000000000000000000000000000000000000902 170.0
HFD2_k127_817450_31 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.00000000000000000000000000000000000000009769 173.0
HFD2_k127_817450_32 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000007319 162.0
HFD2_k127_817450_33 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000142 158.0
HFD2_k127_817450_34 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 0.0000000000000000000000000000000000003262 160.0
HFD2_k127_817450_35 OmpA family K03286 - - 0.0000000000000000000000000000000000004703 155.0
HFD2_k127_817450_36 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000001867 102.0
HFD2_k127_817450_37 Specifically methylates the N7 position of guanine in position 535 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000001813 99.0
HFD2_k127_817450_38 lyase activity - - - 0.0000000000000000005098 102.0
HFD2_k127_817450_39 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000006915 96.0
HFD2_k127_817450_4 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000757 609.0
HFD2_k127_817450_40 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000001227 97.0
HFD2_k127_817450_41 Polymer-forming cytoskeletal - - - 0.00000000000000001946 89.0
HFD2_k127_817450_42 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000003179 89.0
HFD2_k127_817450_43 R3H domain protein K06346 - - 0.0000000000000006303 91.0
HFD2_k127_817450_44 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000861 66.0
HFD2_k127_817450_45 Transposase IS200 like K07491 - - 0.00000000002171 71.0
HFD2_k127_817450_46 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000005524 64.0
HFD2_k127_817450_47 - - - - 0.000002243 56.0
HFD2_k127_817450_48 NfeD-like C-terminal, partner-binding - - - 0.000003465 57.0
HFD2_k127_817450_49 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000169 57.0
HFD2_k127_817450_5 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 551.0
HFD2_k127_817450_50 Protein conserved in bacteria - - - 0.00001996 56.0
HFD2_k127_817450_51 belongs to the sigma-70 factor family, ECF subfamily - - - 0.00002044 53.0
HFD2_k127_817450_52 R3H domain protein K06346 - - 0.00002847 56.0
HFD2_k127_817450_53 exo-alpha-(2->6)-sialidase activity - - - 0.0001415 55.0
HFD2_k127_817450_54 - - - - 0.0004377 51.0
HFD2_k127_817450_6 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 406.0
HFD2_k127_817450_7 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 361.0
HFD2_k127_817450_8 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 380.0
HFD2_k127_817450_9 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 358.0
HFD2_k127_8177117_0 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 477.0
HFD2_k127_8177117_1 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 376.0
HFD2_k127_8177117_10 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000007273 121.0
HFD2_k127_8177117_11 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000001736 112.0
HFD2_k127_8177117_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.0000000000000000000004617 100.0
HFD2_k127_8177117_13 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000008016 87.0
HFD2_k127_8177117_14 Domain of unknown function (DUF4388) - - - 0.000000000007684 78.0
HFD2_k127_8177117_15 Lamin Tail Domain - - - 0.00000000005698 71.0
HFD2_k127_8177117_16 PFAM nucleic acid binding, OB-fold, tRNA - - - 0.0000001229 64.0
HFD2_k127_8177117_17 Sortase family - - - 0.000007508 57.0
HFD2_k127_8177117_18 Lamin Tail Domain - - - 0.0001685 54.0
HFD2_k127_8177117_2 phenylacetate-CoA ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 366.0
HFD2_k127_8177117_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002285 293.0
HFD2_k127_8177117_4 Acyl-CoA reductase (LuxC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000112 270.0
HFD2_k127_8177117_5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella K01195 - 3.2.1.31 0.000000000000000000000000000000000000000000000000000000000000000001091 253.0
HFD2_k127_8177117_6 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000002208 235.0
HFD2_k127_8177117_7 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000008566 221.0
HFD2_k127_8177117_8 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000008977 163.0
HFD2_k127_8177117_9 - - - - 0.0000000000000000000000001423 119.0
HFD2_k127_8185078_0 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000001972 180.0
HFD2_k127_8185078_1 transcriptional regulator K07734 - - 0.00000000000000000000000000000000000004064 146.0
HFD2_k127_8185078_2 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000002157 119.0
HFD2_k127_8207902_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 0.0 1246.0
HFD2_k127_8207902_1 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 1.273e-264 843.0
HFD2_k127_8207902_10 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 301.0
HFD2_k127_8207902_11 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 291.0
HFD2_k127_8207902_12 PFAM Iron permease FTR1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003171 272.0
HFD2_k127_8207902_13 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000001954 189.0
HFD2_k127_8207902_14 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000003653 183.0
HFD2_k127_8207902_15 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000002215 154.0
HFD2_k127_8207902_16 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000000000000000000000000000000005009 149.0
HFD2_k127_8207902_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000653 141.0
HFD2_k127_8207902_18 Efflux ABC transporter, permease protein K02004 - - 0.00000000000000000000000000003577 132.0
HFD2_k127_8207902_19 DNA-binding transcription factor activity - - - 0.000000000000000000000000002366 114.0
HFD2_k127_8207902_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 5.336e-201 653.0
HFD2_k127_8207902_20 Tetratricopeptide repeat - - - 0.0000000000000000000000005328 123.0
HFD2_k127_8207902_21 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000000000000006094 119.0
HFD2_k127_8207902_22 Outer membrane transport energization protein ExbB K03561 - - 0.0000000000000000001312 97.0
HFD2_k127_8207902_23 endonuclease activity K07451 - - 0.0000000000000000001348 94.0
HFD2_k127_8207902_24 transcriptional regulator K21903 - - 0.000000000000001014 83.0
HFD2_k127_8207902_25 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000001876 74.0
HFD2_k127_8207902_26 peptidyl-tyrosine sulfation - - - 0.000000008022 69.0
HFD2_k127_8207902_27 Protein conserved in bacteria K20274 - - 0.000001209 63.0
HFD2_k127_8207902_28 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000172 60.0
HFD2_k127_8207902_29 Outer membrane efflux protein - - - 0.00000624 59.0
HFD2_k127_8207902_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 654.0
HFD2_k127_8207902_30 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00006296 55.0
HFD2_k127_8207902_31 biopolymer transport protein K03559,K03560 - - 0.0001597 53.0
HFD2_k127_8207902_32 Biopolymer transport K03559 - - 0.0002141 51.0
HFD2_k127_8207902_33 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0002593 55.0
HFD2_k127_8207902_34 ompA family - - - 0.0008297 52.0
HFD2_k127_8207902_4 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 551.0
HFD2_k127_8207902_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 505.0
HFD2_k127_8207902_6 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 394.0
HFD2_k127_8207902_7 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009554 379.0
HFD2_k127_8207902_8 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 335.0
HFD2_k127_8207902_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 320.0
HFD2_k127_8211515_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 601.0
HFD2_k127_8211515_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 539.0
HFD2_k127_8211515_10 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000008165 236.0
HFD2_k127_8211515_11 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000006818 203.0
HFD2_k127_8211515_12 Glycosyl transferase family 2 K00721,K00786 - 2.4.1.83 0.00000000000000000000000000000000000000000000000006661 202.0
HFD2_k127_8211515_13 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000001659 181.0
HFD2_k127_8211515_14 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000004367 175.0
HFD2_k127_8211515_15 COG0438 Glycosyltransferase - - - 0.0000000000000000000000000000000000005845 158.0
HFD2_k127_8211515_16 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000005326 144.0
HFD2_k127_8211515_17 glycosyl transferase family 2 - - - 0.0000000000000000000000000003059 125.0
HFD2_k127_8211515_18 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000001422 126.0
HFD2_k127_8211515_19 PFAM polysaccharide export protein K01991 - - 0.0000000000000000000000001501 118.0
HFD2_k127_8211515_2 - Amino acid transport and metabolism K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 499.0
HFD2_k127_8211515_20 Polysaccharide biosynthesis protein - - - 0.0000000000000000000008535 112.0
HFD2_k127_8211515_21 -O-antigen K18814 - - 0.00000000000000000001156 106.0
HFD2_k127_8211515_22 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000000000001049 75.0
HFD2_k127_8211515_23 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000002768 74.0
HFD2_k127_8211515_24 Chain length determinant protein - - - 0.0000001565 64.0
HFD2_k127_8211515_25 polysaccharide biosynthetic process - - - 0.000003258 61.0
HFD2_k127_8211515_26 Psort location CytoplasmicMembrane, score - - - 0.00001499 58.0
HFD2_k127_8211515_27 Capsular exopolysaccharide family - - - 0.0002579 52.0
HFD2_k127_8211515_28 Polysaccharide biosynthesis protein - - - 0.0004308 53.0
HFD2_k127_8211515_3 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 408.0
HFD2_k127_8211515_4 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 354.0
HFD2_k127_8211515_5 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 351.0
HFD2_k127_8211515_6 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 306.0
HFD2_k127_8211515_7 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001501 273.0
HFD2_k127_8211515_8 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006175 252.0
HFD2_k127_8211515_9 protein methyltransferase activity K00568,K02687 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000135 237.0
HFD2_k127_8287778_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 504.0
HFD2_k127_8287778_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 482.0
HFD2_k127_8287778_2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 388.0
HFD2_k127_8287778_3 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000001019 172.0
HFD2_k127_8287778_4 Zinc metalloprotease (Elastase) - - - 0.000000000000000000000000000000000000000000002833 189.0
HFD2_k127_8287778_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000001316 167.0
HFD2_k127_8287778_6 iron-sulfur cluster assembly K07400 - - 0.000000000000000000000000000000000000008703 167.0
HFD2_k127_8287778_7 cell redox homeostasis K02199,K03671 - - 0.00000000000000000000000000000003844 132.0
HFD2_k127_8287778_8 cellulose binding - - - 0.000000000004443 80.0
HFD2_k127_8326996_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 591.0
HFD2_k127_8326996_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 436.0
HFD2_k127_8326996_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.00000000000000000000000009462 123.0
HFD2_k127_8326996_11 PFAM PEGA domain - - - 0.0000000000000006773 93.0
HFD2_k127_8326996_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 431.0
HFD2_k127_8326996_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006177 390.0
HFD2_k127_8326996_4 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 319.0
HFD2_k127_8326996_5 Transglycosylase SLT domain K08307,K12204 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001228 301.0
HFD2_k127_8326996_6 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000000001808 229.0
HFD2_k127_8326996_7 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000008474 214.0
HFD2_k127_8326996_8 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000000005733 184.0
HFD2_k127_8326996_9 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000001393 177.0
HFD2_k127_8328817_0 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.0 1354.0
HFD2_k127_8328817_1 Amylo-alpha-1,6-glucosidase - - - 1.73e-247 804.0
HFD2_k127_8328817_10 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000001738 197.0
HFD2_k127_8328817_11 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000001085 190.0
HFD2_k127_8328817_12 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000001799 187.0
HFD2_k127_8328817_13 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000003131 161.0
HFD2_k127_8328817_14 - - - - 0.0000000000000000000000000000000000002762 160.0
HFD2_k127_8328817_15 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000009371 117.0
HFD2_k127_8328817_16 - - - - 0.00000000000000001426 94.0
HFD2_k127_8328817_17 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.00000000000002822 86.0
HFD2_k127_8328817_18 - - - - 0.0000000000000677 83.0
HFD2_k127_8328817_19 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000007805 79.0
HFD2_k127_8328817_2 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 2.409e-242 777.0
HFD2_k127_8328817_3 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 552.0
HFD2_k127_8328817_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 364.0
HFD2_k127_8328817_5 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 289.0
HFD2_k127_8328817_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008561 310.0
HFD2_k127_8328817_7 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007071 290.0
HFD2_k127_8328817_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000001514 270.0
HFD2_k127_8328817_9 DNA-templated transcription, initiation - - - 0.000000000000000000000000000000000000000000000000000000000007967 221.0
HFD2_k127_8460178_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 575.0
HFD2_k127_8460178_1 MreB/Mbl protein K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 458.0
HFD2_k127_8460178_10 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007763 352.0
HFD2_k127_8460178_11 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 348.0
HFD2_k127_8460178_12 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 343.0
HFD2_k127_8460178_13 Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 327.0
HFD2_k127_8460178_14 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006275 317.0
HFD2_k127_8460178_15 Inositol monophosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 310.0
HFD2_k127_8460178_16 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 309.0
HFD2_k127_8460178_17 ATPases associated with a variety of cellular activities K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 304.0
HFD2_k127_8460178_18 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001153 298.0
HFD2_k127_8460178_19 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002279 262.0
HFD2_k127_8460178_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 480.0
HFD2_k127_8460178_20 Histidine biosynthesis protein K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000002065 274.0
HFD2_k127_8460178_21 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000001914 263.0
HFD2_k127_8460178_22 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000006738 252.0
HFD2_k127_8460178_23 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000002628 246.0
HFD2_k127_8460178_24 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.000000000000000000000000000000000000000000000000000000000000008491 224.0
HFD2_k127_8460178_25 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000002625 232.0
HFD2_k127_8460178_26 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000000000000002316 225.0
HFD2_k127_8460178_27 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000004298 233.0
HFD2_k127_8460178_28 Major intrinsic protein K06188 - - 0.00000000000000000000000000000000000000000000000000000000002129 213.0
HFD2_k127_8460178_29 M6 family metalloprotease domain protein - - - 0.0000000000000000000000000000000000000000000000000001727 213.0
HFD2_k127_8460178_3 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 444.0
HFD2_k127_8460178_30 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000002824 187.0
HFD2_k127_8460178_31 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.00000000000000000000000000000000000000000000007746 189.0
HFD2_k127_8460178_32 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.0000000000000000000000000000000000000000000003397 175.0
HFD2_k127_8460178_33 PFAM ABC transporter related K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000003051 179.0
HFD2_k127_8460178_34 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000001824 149.0
HFD2_k127_8460178_35 Peptidase M56 - - - 0.00000000000000000000000000000004715 140.0
HFD2_k127_8460178_36 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 0.0000000000000000000000000000001553 138.0
HFD2_k127_8460178_37 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000002846 117.0
HFD2_k127_8460178_38 ComF family K02242 - - 0.00000000000000000000000004388 123.0
HFD2_k127_8460178_39 Cell wall-associated hydrolase (invasion-associated protein) - - - 0.000000000000000000000008463 118.0
HFD2_k127_8460178_4 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 453.0
HFD2_k127_8460178_40 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000007476 100.0
HFD2_k127_8460178_41 PFAM Cobalt transport protein K02008 - - 0.00000000000000002314 95.0
HFD2_k127_8460178_42 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000003005 91.0
HFD2_k127_8460178_43 domain protein K21687 - - 0.0000000000002151 84.0
HFD2_k127_8460178_44 - - - - 0.000000000002818 69.0
HFD2_k127_8460178_45 rod shape-determining protein (MreD) K03571 - - 0.0000001061 64.0
HFD2_k127_8460178_46 - - - - 0.0000001804 63.0
HFD2_k127_8460178_47 Type II transport protein GspH K08084 - - 0.00008419 48.0
HFD2_k127_8460178_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 460.0
HFD2_k127_8460178_6 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 439.0
HFD2_k127_8460178_7 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005352 442.0
HFD2_k127_8460178_8 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 425.0
HFD2_k127_8460178_9 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007946 402.0
HFD2_k127_84845_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 453.0
HFD2_k127_84845_1 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 400.0
HFD2_k127_84845_2 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 381.0
HFD2_k127_84845_3 SCP-2 sterol transfer family - - - 0.00000000000000000000000000000000000000000000000000000000000003204 225.0
HFD2_k127_8508221_0 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 1.832e-246 777.0
HFD2_k127_8508221_1 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 587.0
HFD2_k127_8508221_10 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000001185 93.0
HFD2_k127_8508221_12 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000004776 64.0
HFD2_k127_8508221_2 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007084 398.0
HFD2_k127_8508221_3 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 341.0
HFD2_k127_8508221_4 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001623 283.0
HFD2_k127_8508221_5 SprB repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001687 286.0
HFD2_k127_8508221_6 ferredoxin-NADP+ reductase activity - - - 0.000000000000000000000000000000000000006333 160.0
HFD2_k127_8508221_8 - - - - 0.0000000000000000000000000002834 122.0
HFD2_k127_8508221_9 - - - - 0.00000000000000000001746 98.0
HFD2_k127_892689_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000008846 167.0
HFD2_k127_892689_1 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000007387 140.0
HFD2_k127_954007_0 Carbamoyl-phosphate synthetase large chain oligomerisation K01955 - 6.3.5.5 0.0 1208.0
HFD2_k127_954007_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 426.0
HFD2_k127_954007_10 Oxidoreductase NAD-binding domain K02823 - - 0.00000000000000000000000000000001033 148.0
HFD2_k127_954007_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000006208 129.0
HFD2_k127_954007_12 TonB-dependent receptor - - - 0.0003686 53.0
HFD2_k127_954007_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 406.0
HFD2_k127_954007_3 Belongs to the ATCase OTCase family K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 303.0
HFD2_k127_954007_4 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001106 287.0
HFD2_k127_954007_5 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000001329 257.0
HFD2_k127_954007_6 Zinc metalloprotease (Elastase) - - - 0.000000000000000000000000000000000000000000000000000000000000000003243 259.0
HFD2_k127_954007_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000003153 186.0
HFD2_k127_954007_8 LysE type translocator - - - 0.0000000000000000000000000000000000004287 158.0
HFD2_k127_954007_9 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000001669 154.0