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Overview

ID MAG01635
Name HFD2_bin.22
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Limnocylindria
Order Limnocylindrales
Family CSP1-4
Genus UBA5189
Species
Assembly information
Completeness (%) 82.41
Contamination (%) 1.79
GC content (%) 71.0
N50 (bp) 26,905
Genome size (bp) 2,911,365

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2498

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_10219_0 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 447.0
HFD2_k127_10219_1 Hemerythrin HHE cation binding domain - - - 0.0002416 44.0
HFD2_k127_1023577_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002402 227.0
HFD2_k127_1023577_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000001982 201.0
HFD2_k127_1023577_2 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.00000000000000000000000000000002132 133.0
HFD2_k127_1023577_3 YjbR - - - 0.00000000000000000000002607 101.0
HFD2_k127_1061135_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 446.0
HFD2_k127_1061135_1 PFAM ABC transporter related K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003026 377.0
HFD2_k127_1061135_2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000005973 243.0
HFD2_k127_1061135_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000004614 130.0
HFD2_k127_1099458_0 Malate synthase K01638 - 2.3.3.9 1.323e-227 716.0
HFD2_k127_1099458_1 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 503.0
HFD2_k127_1099458_10 OHCU decarboxylase - - - 0.000000000000000003232 98.0
HFD2_k127_1099458_2 PFAM amidohydrolase K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 324.0
HFD2_k127_1099458_3 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000001837 258.0
HFD2_k127_1099458_4 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000001348 203.0
HFD2_k127_1099458_5 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.0000000000000000000000000000000000000000000000005455 184.0
HFD2_k127_1099458_6 Protein of unknown function (DUF3830) - - - 0.0000000000000000000000000000000000000000007642 161.0
HFD2_k127_1099458_7 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000001217 120.0
HFD2_k127_1099458_8 - - - - 0.000000000000000000000000004891 125.0
HFD2_k127_1099458_9 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.00000000000000000000816 97.0
HFD2_k127_1150177_0 MgtE intracellular N domain K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 449.0
HFD2_k127_1150177_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 443.0
HFD2_k127_1150177_10 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000009551 220.0
HFD2_k127_1150177_11 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K12132 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.11.1,5.2.1.8 0.0000000000000000000000000000000000000000001721 164.0
HFD2_k127_1150177_12 AI-2E family transporter - - - 0.00000000000000000000000000000001074 143.0
HFD2_k127_1150177_13 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00000000000000000000000000007709 128.0
HFD2_k127_1150177_14 - - - - 0.000000000000000000000000004259 113.0
HFD2_k127_1150177_15 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000006587 121.0
HFD2_k127_1150177_16 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000003213 109.0
HFD2_k127_1150177_17 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000001072 98.0
HFD2_k127_1150177_18 hyperosmotic response K04065 - - 0.0000000000007461 79.0
HFD2_k127_1150177_19 Cold shock K03704 - - 0.0000000003628 68.0
HFD2_k127_1150177_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 423.0
HFD2_k127_1150177_20 deazaflavin-dependent nitroreductase family protein - - - 0.0000001281 62.0
HFD2_k127_1150177_21 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000009353 48.0
HFD2_k127_1150177_3 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 342.0
HFD2_k127_1150177_4 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 325.0
HFD2_k127_1150177_5 Belongs to the serpin family K13963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000672 295.0
HFD2_k127_1150177_6 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001766 280.0
HFD2_k127_1150177_7 Capsule synthesis protein, CapA K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000009721 256.0
HFD2_k127_1150177_8 CoA-transferase family III K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000615 228.0
HFD2_k127_1150177_9 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.00000000000000000000000000000000000000000000000000000000000009375 228.0
HFD2_k127_11761_0 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007976 391.0
HFD2_k127_11761_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 336.0
HFD2_k127_11761_2 peptidase - - - 0.0000000000000000000000000000000000000000000000000009315 203.0
HFD2_k127_11761_3 Protein conserved in bacteria - - - 0.00000000000000000000000000000000007011 140.0
HFD2_k127_11761_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000001585 138.0
HFD2_k127_11761_5 competence protein COMEC - - - 0.000000000000000000000008861 115.0
HFD2_k127_11761_6 F420H(2)-dependent quinone reductase - - - 0.0000000000000000006313 94.0
HFD2_k127_1177515_0 Glycogen debranching enzyme - - - 1.652e-194 630.0
HFD2_k127_1177515_1 Belongs to the thiolase family K00626,K02615 - 2.3.1.174,2.3.1.223,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 554.0
HFD2_k127_1177515_10 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000009825 191.0
HFD2_k127_1177515_11 Binding-protein-dependent transport system inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000005549 189.0
HFD2_k127_1177515_12 Phenylacetate-CoA oxygenase K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000001538 188.0
HFD2_k127_1177515_13 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000001421 192.0
HFD2_k127_1177515_14 Pfam:DUF59 K02612 - - 0.0000000000000000000000000000000000001343 158.0
HFD2_k127_1177515_15 Glycine betaine K05845 - - 0.000000000000000000000000000000007362 141.0
HFD2_k127_1177515_16 Belongs to the HesB IscA family K13628,K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00000000000000000000000000000001559 134.0
HFD2_k127_1177515_17 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000001056 134.0
HFD2_k127_1177515_18 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000003498 124.0
HFD2_k127_1177515_19 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000001175 123.0
HFD2_k127_1177515_2 Zn-dependent metallo-hydrolase RNA specificity domain K07577,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 483.0
HFD2_k127_1177515_20 - - - - 0.0000000000000000000002992 106.0
HFD2_k127_1177515_21 phenylacetate catabolic process K02610 - - 0.000000000000000001188 89.0
HFD2_k127_1177515_22 AAA ATPase domain - - - 0.00000000000005657 86.0
HFD2_k127_1177515_3 )-transporter K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 385.0
HFD2_k127_1177515_4 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 305.0
HFD2_k127_1177515_5 PFAM oxidoreductase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 285.0
HFD2_k127_1177515_6 Cys/Met metabolism PLP-dependent enzyme K11325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002311 284.0
HFD2_k127_1177515_7 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004691 288.0
HFD2_k127_1177515_8 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000000003818 218.0
HFD2_k127_1177515_9 Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000006162 192.0
HFD2_k127_1179939_0 ABC transporter K06147 - - 4.11e-245 775.0
HFD2_k127_1179939_1 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 8.574e-235 736.0
HFD2_k127_1179939_10 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 418.0
HFD2_k127_1179939_11 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 413.0
HFD2_k127_1179939_12 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 426.0
HFD2_k127_1179939_13 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 411.0
HFD2_k127_1179939_14 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 370.0
HFD2_k127_1179939_15 Exporter of polyketide antibiotics K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 381.0
HFD2_k127_1179939_16 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 362.0
HFD2_k127_1179939_17 Beta-ketoacyl synthase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 342.0
HFD2_k127_1179939_18 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 323.0
HFD2_k127_1179939_19 Methyltransferase type 11 K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 317.0
HFD2_k127_1179939_2 Adenosine/AMP deaminase K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 518.0
HFD2_k127_1179939_20 Belongs to the PstS family K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004881 317.0
HFD2_k127_1179939_21 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 308.0
HFD2_k127_1179939_22 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 309.0
HFD2_k127_1179939_23 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000866 312.0
HFD2_k127_1179939_24 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 293.0
HFD2_k127_1179939_25 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001851 279.0
HFD2_k127_1179939_26 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003188 279.0
HFD2_k127_1179939_27 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006002 277.0
HFD2_k127_1179939_28 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000001614 261.0
HFD2_k127_1179939_29 Malate/L-lactate dehydrogenase K00073 - 1.1.1.350 0.0000000000000000000000000000000000000000000000000000000000000002478 241.0
HFD2_k127_1179939_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 523.0
HFD2_k127_1179939_30 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000005055 243.0
HFD2_k127_1179939_31 TIGRFAM phosphate ABC transporter K02038 - - 0.000000000000000000000000000000000000000000000000000000000006485 229.0
HFD2_k127_1179939_32 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000006962 204.0
HFD2_k127_1179939_33 Isochorismatase family K08281 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 0.000000000000000000000000000000000000000000000000000002765 201.0
HFD2_k127_1179939_34 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000001415 200.0
HFD2_k127_1179939_35 geranylgeranyl reductase activity K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000002109 199.0
HFD2_k127_1179939_36 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000000000000000000000004687 196.0
HFD2_k127_1179939_37 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000003361 198.0
HFD2_k127_1179939_38 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000001084 184.0
HFD2_k127_1179939_39 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000006949 180.0
HFD2_k127_1179939_4 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005894 487.0
HFD2_k127_1179939_40 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000007065 169.0
HFD2_k127_1179939_41 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000009351 164.0
HFD2_k127_1179939_42 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000003382 154.0
HFD2_k127_1179939_43 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000001883 163.0
HFD2_k127_1179939_44 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000006656 163.0
HFD2_k127_1179939_45 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000006307 151.0
HFD2_k127_1179939_46 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000009142 140.0
HFD2_k127_1179939_47 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000009688 152.0
HFD2_k127_1179939_48 integral membrane protein - - - 0.0000000000000000000000000000004545 134.0
HFD2_k127_1179939_49 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000004171 119.0
HFD2_k127_1179939_5 PFAM Prolyl oligopeptidase family K01303 - 3.4.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 493.0
HFD2_k127_1179939_50 Endonuclease/Exonuclease/phosphatase family K18764 - 3.1.13.4 0.00000000000000000000000001402 119.0
HFD2_k127_1179939_51 Domain of unknown function (DUF4260) - - - 0.000000000000000000000002111 108.0
HFD2_k127_1179939_52 Protein of unknown function (DUF971) - - - 0.0000000000000000000004032 104.0
HFD2_k127_1179939_53 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000001009 102.0
HFD2_k127_1179939_54 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000008315 98.0
HFD2_k127_1179939_55 negative regulation of translational initiation K05554,K15885 - - 0.00000000000000000004802 97.0
HFD2_k127_1179939_56 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000007706 105.0
HFD2_k127_1179939_57 ATP-dependent DNA ligase K01971 - 6.5.1.1 0.0000000000000000001258 102.0
HFD2_k127_1179939_58 transcriptional regulator K03892 - - 0.0000000000000000003408 91.0
HFD2_k127_1179939_59 family transcriptional regulator K13652 - - 0.000000000000000171 87.0
HFD2_k127_1179939_6 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 481.0
HFD2_k127_1179939_60 PFAM OsmC family protein K07397 - - 0.0000000000000142 82.0
HFD2_k127_1179939_61 - - - - 0.000000000001547 74.0
HFD2_k127_1179939_62 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000563 70.0
HFD2_k127_1179939_63 metallopeptidase activity K01387 - 3.4.24.3 0.000000001002 70.0
HFD2_k127_1179939_64 - - - - 0.000000002107 64.0
HFD2_k127_1179939_65 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.000006149 59.0
HFD2_k127_1179939_67 - - - - 0.0001412 49.0
HFD2_k127_1179939_68 Hint domain - - - 0.0002154 53.0
HFD2_k127_1179939_7 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 469.0
HFD2_k127_1179939_8 purine-nucleoside phosphorylase activity K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 441.0
HFD2_k127_1179939_9 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009656 449.0
HFD2_k127_1229402_0 Proline racemase K01777 - 5.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 383.0
HFD2_k127_1229402_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 355.0
HFD2_k127_1229402_10 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000006925 69.0
HFD2_k127_1229402_11 Peptidoglycan-binding lysin domain - - - 0.00001496 58.0
HFD2_k127_1229402_2 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K04091 - 1.14.14.5 0.0000000000000000000000000000000000000000000000000000000000000000002633 241.0
HFD2_k127_1229402_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000009679 232.0
HFD2_k127_1229402_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000808 208.0
HFD2_k127_1229402_5 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000009178 213.0
HFD2_k127_1229402_6 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000007216 165.0
HFD2_k127_1229402_7 Superoxide dismutase K00518 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 0.0000000000000000000000000000000000000004157 159.0
HFD2_k127_1229402_8 SIS domain K00820 - 2.6.1.16 0.000000000001208 80.0
HFD2_k127_1229402_9 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000001334 73.0
HFD2_k127_123866_0 Putative glutamine amidotransferase K07114 - - 4.493e-203 666.0
HFD2_k127_123866_1 amine dehydrogenase activity - - - 2.24e-200 646.0
HFD2_k127_123866_10 COGs COG3367 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001535 295.0
HFD2_k127_123866_11 GMC oxidoreductase K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001692 287.0
HFD2_k127_123866_12 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006474 271.0
HFD2_k127_123866_13 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001452 265.0
HFD2_k127_123866_14 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007634 239.0
HFD2_k127_123866_15 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000001459 236.0
HFD2_k127_123866_16 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000003447 242.0
HFD2_k127_123866_18 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000003192 214.0
HFD2_k127_123866_19 N-4 methylation of cytosine K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000001919 203.0
HFD2_k127_123866_2 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 593.0
HFD2_k127_123866_20 ABC-2 family transporter protein - - - 0.00000000000000000000000000006021 132.0
HFD2_k127_123866_21 LysM domain - - - 0.000000000000000000000000001352 132.0
HFD2_k127_123866_22 geranylgeranyl reductase K21401 - 1.3.99.38 0.0000000000000000000000003025 118.0
HFD2_k127_123866_23 Alpha beta hydrolase - - - 0.00000000000000000000007355 109.0
HFD2_k127_123866_24 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000008172 81.0
HFD2_k127_123866_25 - - - - 0.0000000114 63.0
HFD2_k127_123866_26 Two component regulator propeller - - - 0.0000004876 61.0
HFD2_k127_123866_28 homolog of phage Mu protein gp47 - - - 0.000006384 57.0
HFD2_k127_123866_3 PFAM Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 440.0
HFD2_k127_123866_4 AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 414.0
HFD2_k127_123866_5 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 394.0
HFD2_k127_123866_6 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 388.0
HFD2_k127_123866_7 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 378.0
HFD2_k127_123866_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 346.0
HFD2_k127_123866_9 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 312.0
HFD2_k127_1239548_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087 504.0
HFD2_k127_1239548_1 PFAM regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 390.0
HFD2_k127_1239548_10 nitrite reductase [NAD(P)H] activity K05710 - - 0.00000000000000000000000001176 114.0
HFD2_k127_1239548_11 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000005606 76.0
HFD2_k127_1239548_12 ester cyclase - - - 0.00000000001495 73.0
HFD2_k127_1239548_13 Alternative locus ID - - - 0.00000000502 68.0
HFD2_k127_1239548_2 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 343.0
HFD2_k127_1239548_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009301 332.0
HFD2_k127_1239548_4 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005129 299.0
HFD2_k127_1239548_5 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009994 285.0
HFD2_k127_1239548_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.000000000000000000000000000000000000000000000000000000000000000404 223.0
HFD2_k127_1239548_7 PFAM Adenosine AMP deaminase K01488,K18286 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4,3.5.4.40 0.0000000000000000000000000000000000000000000000000005849 196.0
HFD2_k127_1239548_8 Calcineurin-like phosphoesterase K03547 - - 0.0000000000000000000000000001569 129.0
HFD2_k127_1239548_9 Probable zinc-ribbon domain - - - 0.000000000000000000000000002813 117.0
HFD2_k127_1419911_0 ATPases associated with a variety of cellular activities K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 430.0
HFD2_k127_1419911_1 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 320.0
HFD2_k127_1419911_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000192 220.0
HFD2_k127_1419911_11 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000429 170.0
HFD2_k127_1419911_12 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000153 128.0
HFD2_k127_1419911_13 muconolactone delta-isomerase K03464 - 5.3.3.4 0.00000000000000000000000000384 115.0
HFD2_k127_1419911_14 PFAM biotin lipoyl attachment domain-containing protein - - - 0.0000000000000000000000003515 106.0
HFD2_k127_1419911_15 Creatinine amidohydrolase - - - 0.00000000001954 77.0
HFD2_k127_1419911_16 metal-dependent hydrolase of the TIM-barrel fold - - - 0.0004391 44.0
HFD2_k127_1419911_17 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0004594 51.0
HFD2_k127_1419911_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002349 258.0
HFD2_k127_1419911_3 Branched-chain amino acid transport system / permease component K10440,K17206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007238 261.0
HFD2_k127_1419911_4 Branched-chain amino acid transport system / permease component K10440,K17206 - - 0.0000000000000000000000000000000000000000000000000000000000000000001215 258.0
HFD2_k127_1419911_5 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000001945 241.0
HFD2_k127_1419911_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000006142 237.0
HFD2_k127_1419911_7 PFAM catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000148 229.0
HFD2_k127_1419911_8 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000003195 230.0
HFD2_k127_1419911_9 Phosphotriesterase family K07048 - - 0.00000000000000000000000000000000000000000000000000000000000002123 241.0
HFD2_k127_1426659_0 Anticodon-binding domain of tRNA K01870 - 6.1.1.5 4.247e-278 872.0
HFD2_k127_1426659_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 346.0
HFD2_k127_1426659_10 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.000006985 59.0
HFD2_k127_1426659_2 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004196 283.0
HFD2_k127_1426659_3 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000003188 190.0
HFD2_k127_1426659_4 cell envelope-related transcriptional attenuator - - - 0.0000000000000000000000000000000000000007002 169.0
HFD2_k127_1426659_5 Belongs to the glycosyl hydrolase 3 family - - - 0.00000000000000000000000000000000003593 149.0
HFD2_k127_1426659_6 NUBPL iron-transfer P-loop NTPase K02282 - - 0.0000000000000000000000000000001876 143.0
HFD2_k127_1426659_7 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000003686 119.0
HFD2_k127_1426659_8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963,K03111,K15125 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000002184 107.0
HFD2_k127_1426659_9 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000001275 97.0
HFD2_k127_1436771_0 ribosylpyrimidine nucleosidase activity K01239,K01250,K10213 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 3.2.2.1,3.2.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 302.0
HFD2_k127_1436771_1 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002435 264.0
HFD2_k127_1436771_2 Allophanate hydrolase subunit 2 K06350 - - 0.0000000000000000000000000000000000000000000000000002629 201.0
HFD2_k127_1436771_3 Allophanate hydrolase subunit 1 - - - 0.00000000000000000000000000000000000000000006793 177.0
HFD2_k127_1436771_4 Protein of unknown function (DUF1003) - - - 0.000000000000000000001798 100.0
HFD2_k127_1436771_5 Oxidoreductase molybdopterin binding domain - - - 0.00000000000002598 78.0
HFD2_k127_1445624_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 532.0
HFD2_k127_1445624_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 472.0
HFD2_k127_1445624_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000001382 152.0
HFD2_k127_1445624_11 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000005569 134.0
HFD2_k127_1445624_12 May be required for sporulation K09762 - - 0.0000000000001097 83.0
HFD2_k127_1445624_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000002085 69.0
HFD2_k127_1445624_14 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000855 66.0
HFD2_k127_1445624_15 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.00004968 51.0
HFD2_k127_1445624_2 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 343.0
HFD2_k127_1445624_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K01919,K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 325.0
HFD2_k127_1445624_4 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007729 315.0
HFD2_k127_1445624_5 Displays ATPase and GTPase activities K06958 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000002596 252.0
HFD2_k127_1445624_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000001564 221.0
HFD2_k127_1445624_7 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000001318 216.0
HFD2_k127_1445624_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000009114 207.0
HFD2_k127_1445624_9 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000009155 198.0
HFD2_k127_1449585_0 PFAM zinc finger, SWIM domain protein - - - 0.00000000000000000000001042 104.0
HFD2_k127_1468291_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 434.0
HFD2_k127_1468291_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 447.0
HFD2_k127_1468291_2 tRNA binding K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 411.0
HFD2_k127_1468291_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000002625 227.0
HFD2_k127_1468291_4 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.00000000000000000000000000000000000000001518 154.0
HFD2_k127_1468291_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000006356 157.0
HFD2_k127_1468291_6 Regulates arginine biosynthesis genes K03402 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006355,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901605,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000163 118.0
HFD2_k127_1501764_0 Pyridoxal-phosphate dependent enzyme K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007181 407.0
HFD2_k127_1501764_1 Tryptophanyl-tRNA synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 340.0
HFD2_k127_1501764_2 Homoserine dehydrogenase K00003,K12524 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000006236 252.0
HFD2_k127_1501764_3 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000002901 222.0
HFD2_k127_1501764_4 AI-2E family transporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000003117 107.0
HFD2_k127_1501764_5 Pfam:DUF2029 - - - 0.0000000000006809 79.0
HFD2_k127_1501764_6 Non-essential cell division protein that could be required for efficient cell constriction - - - 0.00036 52.0
HFD2_k127_1502678_0 PIN domain K07064 - - 0.0000000000000000000000000000000005759 134.0
HFD2_k127_1502678_1 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.00000000000000000000002736 110.0
HFD2_k127_1502678_2 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656,K03657 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.00000000000001341 85.0
HFD2_k127_1502678_3 SnoaL-like domain - - - 0.00000000001137 65.0
HFD2_k127_1502678_4 positive regulation of growth - - - 0.000000002678 61.0
HFD2_k127_1649963_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 4.395e-202 656.0
HFD2_k127_1649963_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 614.0
HFD2_k127_1649963_10 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 389.0
HFD2_k127_1649963_11 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 382.0
HFD2_k127_1649963_12 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 383.0
HFD2_k127_1649963_13 Glutamate decarboxylase and related PLP-dependent K01580 - 4.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 353.0
HFD2_k127_1649963_14 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 306.0
HFD2_k127_1649963_15 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 303.0
HFD2_k127_1649963_16 COG0604 NADPH quinone reductase and related Zn-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 301.0
HFD2_k127_1649963_17 Serine threonine protein kinase involved in cell cycle control - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001366 297.0
HFD2_k127_1649963_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009714 263.0
HFD2_k127_1649963_19 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000002351 279.0
HFD2_k127_1649963_2 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 586.0
HFD2_k127_1649963_20 Putative sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004482 278.0
HFD2_k127_1649963_21 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001513 256.0
HFD2_k127_1649963_22 DNA glycosylase K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000293 237.0
HFD2_k127_1649963_23 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000001312 211.0
HFD2_k127_1649963_24 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000343 212.0
HFD2_k127_1649963_25 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000000009688 215.0
HFD2_k127_1649963_26 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000004281 216.0
HFD2_k127_1649963_27 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000004623 211.0
HFD2_k127_1649963_28 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000000000002214 212.0
HFD2_k127_1649963_3 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 540.0
HFD2_k127_1649963_30 PFAM Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000008618 187.0
HFD2_k127_1649963_31 PFAM DGPFAETKE family protein - - - 0.000000000000000000000000000000000000000000000000001243 186.0
HFD2_k127_1649963_32 Domain of unknown function (DUF1905) - - - 0.000000000000000000000000000000000000000000000000001629 186.0
HFD2_k127_1649963_33 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000002849 184.0
HFD2_k127_1649963_34 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000009133 175.0
HFD2_k127_1649963_35 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000007028 176.0
HFD2_k127_1649963_36 cyclic nucleotide binding - - - 0.000000000000000000000000000000000000000001627 177.0
HFD2_k127_1649963_37 PFAM Bacterial regulatory protein, arsR family - - - 0.00000000000000000000000000000000000000004087 154.0
HFD2_k127_1649963_38 PFAM Flavodoxin K03809 - 1.6.5.2 0.000000000000000000000000000000000000000287 159.0
HFD2_k127_1649963_39 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.00000000000000000000000000000000000003215 150.0
HFD2_k127_1649963_4 DEAD DEAH box helicase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 527.0
HFD2_k127_1649963_40 Aminoglycoside 2'-N-acetyltransferase K17840 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658 2.3.1.59 0.0000000000000000000000000000000000001211 150.0
HFD2_k127_1649963_41 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000002452 152.0
HFD2_k127_1649963_42 Protein of unknown function (DUF3037) - - - 0.0000000000000000000000000000000003101 140.0
HFD2_k127_1649963_43 YCII-related domain - - - 0.0000000000000000000000000000000364 129.0
HFD2_k127_1649963_44 TIGRFAM competence damage-inducible protein CinA K03742,K03743 - 3.5.1.42 0.0000000000000000000000000000001582 142.0
HFD2_k127_1649963_45 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000001009 127.0
HFD2_k127_1649963_46 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000004068 121.0
HFD2_k127_1649963_47 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000006708 128.0
HFD2_k127_1649963_48 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000005188 111.0
HFD2_k127_1649963_49 ThiS family - - - 0.00000000000000000000001451 105.0
HFD2_k127_1649963_5 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 501.0
HFD2_k127_1649963_50 Secreted repeat of unknown function - - - 0.00000000000000000000004247 108.0
HFD2_k127_1649963_51 FR47-like protein - - - 0.0000000000000000009187 96.0
HFD2_k127_1649963_52 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000189 89.0
HFD2_k127_1649963_53 Histidine kinase - - - 0.000000000000000008195 96.0
HFD2_k127_1649963_54 Cupin - - - 0.00000000000000008362 93.0
HFD2_k127_1649963_55 - K06197 - - 0.0000000000000003553 81.0
HFD2_k127_1649963_56 SnoaL-like domain - - - 0.000000000000003721 83.0
HFD2_k127_1649963_57 Domain of unknown function (DUF4115) - - - 0.00000000000005123 85.0
HFD2_k127_1649963_58 translation initiation factor activity - - - 0.0000000000009922 73.0
HFD2_k127_1649963_59 positive regulation of macromolecule biosynthetic process K03970,K03973 - - 0.000000000006227 76.0
HFD2_k127_1649963_6 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 486.0
HFD2_k127_1649963_60 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000005728 68.0
HFD2_k127_1649963_61 Major facilitator Superfamily - - - 0.0000002047 63.0
HFD2_k127_1649963_62 PFAM intradiol ring-cleavage dioxygenase - - - 0.000002823 52.0
HFD2_k127_1649963_63 - - - - 0.000004515 57.0
HFD2_k127_1649963_64 TadE-like protein - - - 0.00001526 54.0
HFD2_k127_1649963_65 TadE-like protein - - - 0.0001225 52.0
HFD2_k127_1649963_66 Putative Flp pilus-assembly TadE/G-like - - - 0.0002028 54.0
HFD2_k127_1649963_67 - - - - 0.0002199 52.0
HFD2_k127_1649963_7 FtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 478.0
HFD2_k127_1649963_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 466.0
HFD2_k127_1649963_9 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 454.0
HFD2_k127_165849_0 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 507.0
HFD2_k127_165849_1 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 478.0
HFD2_k127_165849_10 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002235 266.0
HFD2_k127_165849_11 SMART HNH nuclease - - - 0.00000000000000000000000000000000000000000000000000000000000002664 218.0
HFD2_k127_165849_12 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000009719 199.0
HFD2_k127_165849_13 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.000000000000000000000000000000000000000000000002594 179.0
HFD2_k127_165849_14 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000001036 190.0
HFD2_k127_165849_15 Response regulator receiver - - - 0.00000000000000000000000000000000000000000002507 173.0
HFD2_k127_165849_16 Histidine kinase A domain protein - - - 0.000000000000000000000000000000002115 147.0
HFD2_k127_165849_17 dna ligase - - - 0.00000007931 62.0
HFD2_k127_165849_18 Polymer-forming cytoskeletal - - - 0.000001073 62.0
HFD2_k127_165849_2 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 458.0
HFD2_k127_165849_3 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 379.0
HFD2_k127_165849_4 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 330.0
HFD2_k127_165849_5 Probable RNA and SrmB- binding site of polymerase A K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 332.0
HFD2_k127_165849_6 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 315.0
HFD2_k127_165849_7 Carbon-nitrogen hydrolase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000349 294.0
HFD2_k127_165849_8 Protein of unknown function (DUF1211) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006753 256.0
HFD2_k127_165849_9 Belongs to the glycerate kinase type-1 family K00865 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000006308 275.0
HFD2_k127_167672_0 Cell division protein FtsA K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 454.0
HFD2_k127_167672_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004306 284.0
HFD2_k127_174079_0 ABC transporter, transmembrane region K06147 - - 3.008e-265 851.0
HFD2_k127_174079_1 ABC transporter, transmembrane region K06147 - - 4.908e-214 680.0
HFD2_k127_174079_10 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.00000000000000000000000000001101 129.0
HFD2_k127_174079_11 Rieske 2Fe-2S - - - 0.000000000000000000000773 105.0
HFD2_k127_174079_12 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000002873 95.0
HFD2_k127_174079_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000002494 69.0
HFD2_k127_174079_14 Domain of unknown function (DUF309) K09763 - - 0.000000002564 66.0
HFD2_k127_174079_15 Kelch motif - - - 0.00000001963 67.0
HFD2_k127_174079_2 PFAM aminotransferase, class I K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 461.0
HFD2_k127_174079_3 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 377.0
HFD2_k127_174079_4 Exporter of polyketide antibiotics K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 373.0
HFD2_k127_174079_5 Cytochrome b/b6/petB K03891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 337.0
HFD2_k127_174079_6 'glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000025 231.0
HFD2_k127_174079_7 FR47-like protein K06976 - - 0.0000000000000000000000000000000000000000000000482 182.0
HFD2_k127_174079_8 phosphorelay signal transduction system K07667 - - 0.000000000000000000000000000000000002503 152.0
HFD2_k127_174079_9 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000000000004661 141.0
HFD2_k127_176211_0 Phosphofructokinase K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009042 443.0
HFD2_k127_176211_1 Alternative locus ID K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 317.0
HFD2_k127_176211_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000001939 236.0
HFD2_k127_176211_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000002788 125.0
HFD2_k127_176211_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000002538 104.0
HFD2_k127_176211_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000004474 85.0
HFD2_k127_1780518_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 7.995e-194 623.0
HFD2_k127_1780518_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 585.0
HFD2_k127_1780518_10 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000008124 204.0
HFD2_k127_1780518_11 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000253 194.0
HFD2_k127_1780518_12 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.00000000000000000000000000000000000000486 162.0
HFD2_k127_1780518_13 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000002213 154.0
HFD2_k127_1780518_14 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000001802 141.0
HFD2_k127_1780518_15 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000002899 136.0
HFD2_k127_1780518_16 Cupin 2, conserved barrel domain protein - - - 0.00000000000000008147 81.0
HFD2_k127_1780518_17 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000003537 58.0
HFD2_k127_1780518_18 PFAM Colicin V production protein K03558 - - 0.0003034 50.0
HFD2_k127_1780518_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 545.0
HFD2_k127_1780518_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 370.0
HFD2_k127_1780518_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 361.0
HFD2_k127_1780518_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 314.0
HFD2_k127_1780518_6 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 311.0
HFD2_k127_1780518_7 PFAM glycosyl transferase, family 51 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004644 299.0
HFD2_k127_1780518_8 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000002529 203.0
HFD2_k127_1780518_9 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000002091 201.0
HFD2_k127_1781097_0 PFAM Helicase conserved C-terminal domain K06877 - - 1.231e-242 769.0
HFD2_k127_1781097_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.234e-240 760.0
HFD2_k127_1781097_10 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.0000000000000000000000000000008114 139.0
HFD2_k127_1781097_11 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000006811 129.0
HFD2_k127_1781097_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 608.0
HFD2_k127_1781097_3 Peptidase dimerisation domain K01436,K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 494.0
HFD2_k127_1781097_4 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 305.0
HFD2_k127_1781097_5 Participates in initiation and elongation during chromosome replication K02314,K02316,K17680 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000009689 252.0
HFD2_k127_1781097_6 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000005902 245.0
HFD2_k127_1781097_7 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000007262 170.0
HFD2_k127_1781097_8 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000006041 164.0
HFD2_k127_1781097_9 phosphoesterase (MutT family) - - - 0.00000000000000000000000000000001826 136.0
HFD2_k127_1784665_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 557.0
HFD2_k127_1784665_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 479.0
HFD2_k127_1784665_10 Septum formation - - - 0.0000000000009182 77.0
HFD2_k127_1784665_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 421.0
HFD2_k127_1784665_3 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 384.0
HFD2_k127_1784665_4 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000762 369.0
HFD2_k127_1784665_5 PFAM Metallophosphoesterase K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003967 280.0
HFD2_k127_1784665_6 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000722 194.0
HFD2_k127_1784665_7 Cupin domain - - - 0.0000000000000000000000000000000000000000000000459 171.0
HFD2_k127_1784665_8 SnoaL-like domain K06893 - - 0.0000000000000000002346 93.0
HFD2_k127_1784665_9 Modulates RecA activity K03565 - - 0.000000000000002023 83.0
HFD2_k127_1804983_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 619.0
HFD2_k127_1804983_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 412.0
HFD2_k127_1804983_10 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 0.0000000000000000000000000000000000000000000000000000002089 207.0
HFD2_k127_1804983_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000001057 197.0
HFD2_k127_1804983_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000002184 192.0
HFD2_k127_1804983_13 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000001399 178.0
HFD2_k127_1804983_14 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000002159 181.0
HFD2_k127_1804983_15 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000001592 162.0
HFD2_k127_1804983_16 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001445 164.0
HFD2_k127_1804983_17 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000003614 166.0
HFD2_k127_1804983_18 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000003833 153.0
HFD2_k127_1804983_19 PFAM ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000006663 136.0
HFD2_k127_1804983_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 393.0
HFD2_k127_1804983_20 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000003521 138.0
HFD2_k127_1804983_21 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.000000000000000000000000000000003118 129.0
HFD2_k127_1804983_22 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000004383 110.0
HFD2_k127_1804983_23 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000003229 104.0
HFD2_k127_1804983_24 PFAM YbbR family protein - - - 0.000000000000000000002641 107.0
HFD2_k127_1804983_25 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000002953 85.0
HFD2_k127_1804983_26 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000001986 71.0
HFD2_k127_1804983_27 DNA binding - - - 0.000000002332 68.0
HFD2_k127_1804983_28 Ribosomal protein L30p/L7e K02907 - - 0.00000000401 62.0
HFD2_k127_1804983_29 Tetratricopeptide repeat - - - 0.0000006124 62.0
HFD2_k127_1804983_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 327.0
HFD2_k127_1804983_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 303.0
HFD2_k127_1804983_5 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004646 291.0
HFD2_k127_1804983_6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007999 271.0
HFD2_k127_1804983_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000006389 256.0
HFD2_k127_1804983_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002429 242.0
HFD2_k127_1804983_9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000008602 217.0
HFD2_k127_1817984_0 Sigma-54 interaction domain K03696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 443.0
HFD2_k127_1817984_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 425.0
HFD2_k127_1817984_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 407.0
HFD2_k127_1817984_3 SMART Nucleotide binding protein, PINc - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 307.0
HFD2_k127_1817984_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000001822 204.0
HFD2_k127_1817984_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.000000000000000000000000000000005507 134.0
HFD2_k127_1817984_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000515 82.0
HFD2_k127_1823043_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 413.0
HFD2_k127_1823043_1 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.000000000003755 75.0
HFD2_k127_1832100_0 Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 430.0
HFD2_k127_1832100_1 DegT/DnrJ/EryC1/StrS aminotransferase family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 399.0
HFD2_k127_1832100_10 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046570,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.109 0.000000000001678 72.0
HFD2_k127_1832100_11 SurA N-terminal domain K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.00000000271 70.0
HFD2_k127_1832100_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007519 275.0
HFD2_k127_1832100_3 TIGRFAM MazG family protein K02428,K02499 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000003142 241.0
HFD2_k127_1832100_4 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000003949 227.0
HFD2_k127_1832100_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000004249 173.0
HFD2_k127_1832100_6 Bacterial sugar transferase - - - 0.000000000000000000000000000000000000008885 157.0
HFD2_k127_1832100_7 PFAM O-Antigen K18814 - - 0.000000000000000000001352 111.0
HFD2_k127_1832100_8 PFAM O-Antigen ligase - - - 0.0000000000000000001737 102.0
HFD2_k127_1832100_9 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000006719 83.0
HFD2_k127_1864234_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.185e-240 769.0
HFD2_k127_1864234_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 5.549e-220 714.0
HFD2_k127_1864234_10 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 319.0
HFD2_k127_1864234_11 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 299.0
HFD2_k127_1864234_12 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 305.0
HFD2_k127_1864234_13 PFAM Sodium calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 296.0
HFD2_k127_1864234_14 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002425 289.0
HFD2_k127_1864234_15 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005954 256.0
HFD2_k127_1864234_16 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000002133 259.0
HFD2_k127_1864234_17 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000004658 237.0
HFD2_k127_1864234_18 PFAM DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000003251 198.0
HFD2_k127_1864234_19 lactoylglutathione lyase activity - - - 0.000000000000000000000000008275 115.0
HFD2_k127_1864234_2 GTP-binding protein TypA K06207 - - 2.68e-216 689.0
HFD2_k127_1864234_20 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000002671 111.0
HFD2_k127_1864234_21 Histidine kinase-like ATPases - - - 0.0000000000000000000006522 110.0
HFD2_k127_1864234_22 MobA-like NTP transferase domain K07141,K19190 - 1.1.1.328,2.7.7.76 0.0000501 55.0
HFD2_k127_1864234_23 - - - - 0.000051 54.0
HFD2_k127_1864234_3 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.274e-197 635.0
HFD2_k127_1864234_4 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 7.714e-195 634.0
HFD2_k127_1864234_5 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008006 398.0
HFD2_k127_1864234_6 Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 396.0
HFD2_k127_1864234_7 cell division - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 373.0
HFD2_k127_1864234_8 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 370.0
HFD2_k127_1864234_9 Aminotransferase class-V K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 366.0
HFD2_k127_1921512_0 - - - - 0.000000000000000000000000000000000000000000002161 186.0
HFD2_k127_1921512_1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000001962 104.0
HFD2_k127_1966866_0 DEAD DEAH box helicase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008873 508.0
HFD2_k127_1966866_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 480.0
HFD2_k127_1966866_10 abc transporter K01990 - - 0.000000000000000000000000000000000000000001024 162.0
HFD2_k127_1966866_11 PFAM DeoC LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000002455 161.0
HFD2_k127_1966866_12 PAC2 family - - - 0.000000000000000000000000000000000000009132 154.0
HFD2_k127_1966866_13 Putative sugar-binding domain - - - 0.0000000000000000000000000000000000004919 156.0
HFD2_k127_1966866_14 PFAM PTS system sorbose subfamily IIB component K02794 - 2.7.1.191 0.000000000000000000000000000000000006084 142.0
HFD2_k127_1966866_15 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000002003 143.0
HFD2_k127_1966866_16 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000001081 122.0
HFD2_k127_1966866_17 Protein of unknown function (DUF2089) - - - 0.00000000000000000000000000792 115.0
HFD2_k127_1966866_18 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000008877 119.0
HFD2_k127_1966866_19 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000002408 109.0
HFD2_k127_1966866_2 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 387.0
HFD2_k127_1966866_20 Alpha/beta hydrolase family K07020 - - 0.00000000000000002555 94.0
HFD2_k127_1966866_21 Glyoxalase-like domain - - - 0.00000000000000002931 86.0
HFD2_k127_1966866_22 PTS system fructose IIA component K02793 - 2.7.1.191 0.000000000003401 73.0
HFD2_k127_1966866_23 Putative stress-induced transcription regulator - - - 0.000000000004965 74.0
HFD2_k127_1966866_24 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676,K18917 - 1.20.4.3 0.000002217 58.0
HFD2_k127_1966866_25 Putative adhesin - - - 0.0001135 54.0
HFD2_k127_1966866_26 - - - - 0.0001534 52.0
HFD2_k127_1966866_3 PTS system mannose/fructose/sorbose family IID component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 298.0
HFD2_k127_1966866_4 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005233 263.0
HFD2_k127_1966866_5 PFAM ABC transporter related K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000001365 263.0
HFD2_k127_1966866_6 PFAM phosphotransferase system PTS sorbose-specific IIC subunit K02795 - - 0.000000000000000000000000000000000000000000000000000002244 206.0
HFD2_k127_1966866_7 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000003416 201.0
HFD2_k127_1966866_8 PFAM HhH-GPD family protein - - - 0.00000000000000000000000000000000000000000000001902 183.0
HFD2_k127_1990178_0 Exonuclease K07502 - - 0.00000000000000000000000000000000000000004627 171.0
HFD2_k127_1990178_1 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000003021 59.0
HFD2_k127_2005259_0 Sterol carrier protein domain - - - 0.000000000000000000000000000000000000007045 159.0
HFD2_k127_2005259_1 transcriptional regulator - - - 0.000000000000000000000001371 108.0
HFD2_k127_2005259_2 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000127 109.0
HFD2_k127_2030621_0 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 479.0
HFD2_k127_2030621_1 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000006382 248.0
HFD2_k127_2030621_2 - - - - 0.0000000000000000744 85.0
HFD2_k127_2030621_3 Antibiotic biosynthesis monooxygenase - - - 0.000000000424 70.0
HFD2_k127_2043615_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1068.0
HFD2_k127_2043615_1 FGGY family of carbohydrate kinases, N-terminal domain - - - 2.379e-207 657.0
HFD2_k127_2043615_10 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000006448 228.0
HFD2_k127_2043615_11 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000009319 216.0
HFD2_k127_2043615_12 Iron permease FTR1 K07243 - - 0.000000000000000000000000000000000000000000000000000005381 201.0
HFD2_k127_2043615_13 NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.000000000000000000000000000000000000000000000003199 189.0
HFD2_k127_2043615_14 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000006118 154.0
HFD2_k127_2043615_15 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000002651 153.0
HFD2_k127_2043615_16 Protein of unknown function (DUF3090) - - - 0.0000000000000000000000000000000000002778 147.0
HFD2_k127_2043615_17 Cupin domain - - - 0.0000000000000000000000000000000008052 136.0
HFD2_k127_2043615_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000001291 130.0
HFD2_k127_2043615_19 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.00000000000000000000000004238 126.0
HFD2_k127_2043615_2 Large extracellular alpha-helical protein K06894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 556.0
HFD2_k127_2043615_3 Cysteine desulfurase family protein, VC1184 subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 415.0
HFD2_k127_2043615_4 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 327.0
HFD2_k127_2043615_5 Acetylornithine deacetylase K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 299.0
HFD2_k127_2043615_6 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003038 293.0
HFD2_k127_2043615_7 Phosphatidylinositol - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001117 264.0
HFD2_k127_2043615_8 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002627 263.0
HFD2_k127_2043615_9 PFAM oxidoreductase molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001863 248.0
HFD2_k127_205353_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 1.049e-217 706.0
HFD2_k127_205353_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005378 605.0
HFD2_k127_205353_10 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002098 257.0
HFD2_k127_205353_11 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000002373 226.0
HFD2_k127_205353_12 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000001832 226.0
HFD2_k127_205353_13 (Rhomboid) family K07059 - - 0.00000000000000000000000000000000000000000000000000000000001185 218.0
HFD2_k127_205353_14 outer membrane autotransporter K12287,K12686 - - 0.0000000000000000000000000000000000000000000005336 188.0
HFD2_k127_205353_15 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000003835 185.0
HFD2_k127_205353_16 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000003166 153.0
HFD2_k127_205353_17 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000001057 153.0
HFD2_k127_205353_18 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000003046 140.0
HFD2_k127_205353_19 lipid A biosynthesis acyltransferase K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.0000000000000000000000000000008215 140.0
HFD2_k127_205353_2 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 575.0
HFD2_k127_205353_20 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.000000000000000000000000000003891 141.0
HFD2_k127_205353_21 PFAM single-stranded nucleic acid binding R3H domain protein K06346 - - 0.0000000000000000000000008243 122.0
HFD2_k127_205353_22 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000003454 120.0
HFD2_k127_205353_23 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000001877 108.0
HFD2_k127_205353_24 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000006809 100.0
HFD2_k127_205353_25 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000001995 89.0
HFD2_k127_205353_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000008141 87.0
HFD2_k127_205353_27 Membrane protein insertase, YidC Oxa1 family K03217 - - 0.0000000000005016 81.0
HFD2_k127_205353_28 Dystroglycan-type cadherin-like domains. - - - 0.0000000000007183 82.0
HFD2_k127_205353_29 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.000000000001049 77.0
HFD2_k127_205353_3 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 491.0
HFD2_k127_205353_30 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000113 76.0
HFD2_k127_205353_31 DNA-binding transcription factor activity K03892 - - 0.00000000001873 69.0
HFD2_k127_205353_32 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000001699 62.0
HFD2_k127_205353_33 protein serine/threonine phosphatase activity - - - 0.0000000001762 75.0
HFD2_k127_205353_34 Bacterial lipid A biosynthesis acyltransferase K02517,K22311 - 2.3.1.241,2.3.1.265 0.00000004294 66.0
HFD2_k127_205353_36 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000447 42.0
HFD2_k127_205353_4 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 459.0
HFD2_k127_205353_5 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 353.0
HFD2_k127_205353_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 342.0
HFD2_k127_205353_7 Glycosyl transferase 4-like domain K08256 - 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 312.0
HFD2_k127_205353_8 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 317.0
HFD2_k127_205353_9 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006676 295.0
HFD2_k127_2078138_0 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 606.0
HFD2_k127_2078138_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 351.0
HFD2_k127_2078138_10 Sortilin, neurotensin receptor 3, - - - 0.000006337 60.0
HFD2_k127_2078138_2 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000005494 227.0
HFD2_k127_2078138_3 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000009093 171.0
HFD2_k127_2078138_4 - - - - 0.00000000000000000000000000000000000151 146.0
HFD2_k127_2078138_5 AAA ATPase domain - - - 0.0000000000000000000000002607 108.0
HFD2_k127_2078138_7 - - - - 0.0000000000000001021 91.0
HFD2_k127_2078138_9 Protein of unknown function (DUF4242) - - - 0.0000004135 56.0
HFD2_k127_2098386_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 444.0
HFD2_k127_2098386_1 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 384.0
HFD2_k127_2098386_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 377.0
HFD2_k127_2098386_3 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009693 342.0
HFD2_k127_2098386_4 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001781 264.0
HFD2_k127_2098386_5 domain, Protein - - - 0.00000000000000000000000000000000000000000000002441 190.0
HFD2_k127_2098386_6 Transcriptional regulator - - - 0.0000000000000000000000000000009379 136.0
HFD2_k127_217773_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.349e-198 632.0
HFD2_k127_217773_1 Belongs to the aldehyde dehydrogenase family K00130 - 1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 513.0
HFD2_k127_217773_10 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000001584 145.0
HFD2_k127_217773_11 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000006872 136.0
HFD2_k127_217773_12 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000836 130.0
HFD2_k127_217773_13 ThiS family K03636 - - 0.00000000000000000001557 97.0
HFD2_k127_217773_14 - - - - 0.000000000000005609 85.0
HFD2_k127_217773_15 - - - - 0.00007211 49.0
HFD2_k127_217773_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 464.0
HFD2_k127_217773_3 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 448.0
HFD2_k127_217773_4 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008641 411.0
HFD2_k127_217773_5 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 376.0
HFD2_k127_217773_6 Dehydrogenase E1 component K00166 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006521 372.0
HFD2_k127_217773_7 endonuclease III K03575 - - 0.00000000000000000000000000000000000000000000000000000000001983 220.0
HFD2_k127_217773_8 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000001709 194.0
HFD2_k127_217773_9 Transcriptional regulator - - - 0.000000000000000000000000000000000006135 147.0
HFD2_k127_2198898_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 588.0
HFD2_k127_2198898_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 312.0
HFD2_k127_2198898_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000005641 261.0
HFD2_k127_2198898_3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000007249 235.0
HFD2_k127_2198898_4 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000002295 201.0
HFD2_k127_2198898_5 zinc metalloprotease K04771,K11749,K16922 GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 0.000000000000000000000000000000000000000000000006579 186.0
HFD2_k127_2198898_6 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000003245 145.0
HFD2_k127_2198898_7 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000005981 78.0
HFD2_k127_2288_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 516.0
HFD2_k127_2288_1 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000005324 240.0
HFD2_k127_2288_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000004475 63.0
HFD2_k127_2377346_0 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000005658 235.0
HFD2_k127_2377346_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000001991 222.0
HFD2_k127_2377346_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000004478 102.0
HFD2_k127_2377346_3 Belongs to the UPF0102 family K07460 - - 0.0000000001517 67.0
HFD2_k127_2396105_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 442.0
HFD2_k127_2396105_1 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000002772 206.0
HFD2_k127_2396105_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000001726 83.0
HFD2_k127_2396105_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000635 79.0
HFD2_k127_2396105_4 PIN domain - - - 0.0000000000008099 79.0
HFD2_k127_2396105_5 Ribbon-helix-helix protein, copG family - - - 0.0000000000429 66.0
HFD2_k127_2396105_6 Type I restriction-modification system methyltransferase subunit - - - 0.0000002772 62.0
HFD2_k127_2396105_7 COGs COG2452 site-specific integrase-resolvase - - - 0.0007259 45.0
HFD2_k127_250539_0 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 - 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 484.0
HFD2_k127_250539_1 PFAM PrpF protein K20451 - 5.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 389.0
HFD2_k127_250539_10 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000001123 227.0
HFD2_k127_250539_11 aspartate dehydrogenase activity K06989 - 1.4.1.21 0.0000000000000000000000000000000000000000000000000000000000212 223.0
HFD2_k127_250539_12 Domain of unknown function (DUF3291) - - - 0.00000000000000000000000000000000000000000001822 171.0
HFD2_k127_250539_13 FCD - - - 0.00000000000000000000000000000000000000000006424 168.0
HFD2_k127_250539_14 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000001082 175.0
HFD2_k127_250539_15 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000001568 149.0
HFD2_k127_250539_16 Asparaginase K01424 - 3.5.1.1 0.000000000000000000000000000000000012 138.0
HFD2_k127_250539_17 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000001422 148.0
HFD2_k127_250539_18 serine-type peptidase activity - - - 0.000000000000000000000000000000001942 143.0
HFD2_k127_250539_19 Methyltransferase K10218 - 4.1.3.17 0.000000000000000000000000000002355 138.0
HFD2_k127_250539_2 Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate and vanillate K01612,K16874 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 4.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006662 358.0
HFD2_k127_250539_20 NMT1/THI5 like K02051 - - 0.00000000000000000000000000333 124.0
HFD2_k127_250539_21 Catalyzes the conversion of maleate to fumarate K01799 - 5.2.1.1 0.000000000000000000005543 102.0
HFD2_k127_250539_22 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.000001043 61.0
HFD2_k127_250539_24 Protein of unknown function (DUF4242) - - - 0.000006537 52.0
HFD2_k127_250539_3 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 357.0
HFD2_k127_250539_4 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 302.0
HFD2_k127_250539_5 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 297.0
HFD2_k127_250539_6 Protein of unknown function DUF262 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003893 283.0
HFD2_k127_250539_7 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001263 265.0
HFD2_k127_250539_8 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001062 246.0
HFD2_k127_250539_9 L11 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000006654 228.0
HFD2_k127_2594818_0 Poly(3-hydroxybutyrate) depolymerase K03932 - - 0.00000000000000000000000000000000000000009535 165.0
HFD2_k127_2594818_1 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000949 122.0
HFD2_k127_2594818_2 - - - - 0.0003618 51.0
HFD2_k127_2594818_3 Coagulation factor 5 8 type domain protein - - - 0.0005773 53.0
HFD2_k127_2637564_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 1.362e-228 732.0
HFD2_k127_2637564_1 R3H domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 557.0
HFD2_k127_2637564_10 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000001425 229.0
HFD2_k127_2637564_11 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000001787 231.0
HFD2_k127_2637564_12 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000001589 204.0
HFD2_k127_2637564_13 SnoaL-like polyketide cyclase K15945 - - 0.00000000000000000000000000000000000000000000000000003518 195.0
HFD2_k127_2637564_14 MOSC domain containing protein K07140 - - 0.0000000000000000000000000000000000000000000000009957 190.0
HFD2_k127_2637564_15 Cyclic-di-AMP receptor - - - 0.000000000000000000000000000000006647 134.0
HFD2_k127_2637564_16 Diguanylate cyclase - - - 0.00000000000000000000000004043 120.0
HFD2_k127_2637564_17 Glyoxalase-like domain - - - 0.000000000000000000000000233 117.0
HFD2_k127_2637564_19 Belongs to the GbsR family - - - 0.0000000000000828 81.0
HFD2_k127_2637564_2 metallopeptidase activity K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 500.0
HFD2_k127_2637564_20 nUDIX hydrolase K01515,K03574,K03801,K08310 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008828,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019177,GO:0019438,GO:0019752,GO:0034641,GO:0042364,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0046872,GO:0047429,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.181,3.6.1.13,3.6.1.55,3.6.1.67 0.000000000000122 77.0
HFD2_k127_2637564_21 - - - - 0.00000003262 63.0
HFD2_k127_2637564_22 - - - - 0.00004076 56.0
HFD2_k127_2637564_3 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 458.0
HFD2_k127_2637564_4 Mycobacterial 4 TMS phage holin, superfamily IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 445.0
HFD2_k127_2637564_5 PFAM IMP dehydrogenase GMP reductase K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 377.0
HFD2_k127_2637564_6 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 302.0
HFD2_k127_2637564_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 299.0
HFD2_k127_2637564_8 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004986 277.0
HFD2_k127_2637564_9 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001302 265.0
HFD2_k127_2645206_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 5.5e-241 763.0
HFD2_k127_2652051_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 5.969e-248 796.0
HFD2_k127_2652051_1 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 1.408e-247 804.0
HFD2_k127_2652051_10 ABC transporter substrate-binding protein K10232 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 381.0
HFD2_k127_2652051_11 Cell cycle protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 352.0
HFD2_k127_2652051_12 PFAM Binding-protein-dependent transport system inner membrane component K02025,K10233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 318.0
HFD2_k127_2652051_13 ABC-type sugar transport system, permease component K10234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 304.0
HFD2_k127_2652051_14 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 328.0
HFD2_k127_2652051_15 ABC-type sugar transport system periplasmic component K10232 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 296.0
HFD2_k127_2652051_16 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003441 261.0
HFD2_k127_2652051_17 Periplasmic binding protein domain K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000006716 232.0
HFD2_k127_2652051_18 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - - 0.00000000000000000000000000000000000000000000000000000000000000109 248.0
HFD2_k127_2652051_19 PFAM penicillin-binding protein transpeptidase K05364 - - 0.000000000000000000000000000000000000000000000000000000000000001603 248.0
HFD2_k127_2652051_2 SMART alpha amylase catalytic sub domain K01187 - 3.2.1.20 2.34e-215 680.0
HFD2_k127_2652051_20 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000003678 218.0
HFD2_k127_2652051_21 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000007108 232.0
HFD2_k127_2652051_22 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000004248 220.0
HFD2_k127_2652051_23 helix_turn_helix, Lux Regulon K02479 - - 0.000000000000000000000000000000000000000000000000000000006576 206.0
HFD2_k127_2652051_24 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000001003 191.0
HFD2_k127_2652051_25 InterPro IPR014922 - - - 0.00000000000000000000000000000000000000000000000001373 188.0
HFD2_k127_2652051_26 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000000000001557 198.0
HFD2_k127_2652051_27 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000002038 157.0
HFD2_k127_2652051_28 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000001623 134.0
HFD2_k127_2652051_29 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000001479 137.0
HFD2_k127_2652051_3 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 507.0
HFD2_k127_2652051_30 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000002314 116.0
HFD2_k127_2652051_31 PFAM Forkhead-associated protein - - - 0.0000000000000000000000006271 117.0
HFD2_k127_2652051_32 Belongs to the phosphoglycerate mutase family K22305 - 3.1.3.3 0.000000000000000000000004378 115.0
HFD2_k127_2652051_33 Histidine kinase - - - 0.00000000000000000000001495 115.0
HFD2_k127_2652051_34 Protein of unknown function (DUF4446) - - - 0.00000000000000001095 92.0
HFD2_k127_2652051_35 HAD-hyrolase-like K07025 - - 0.000000000000003136 88.0
HFD2_k127_2652051_36 Putative regulatory protein - - - 0.0000000002 70.0
HFD2_k127_2652051_37 Virulence factor BrkB K07058 - - 0.00001082 58.0
HFD2_k127_2652051_38 helix_turn_helix, Lux Regulon K07684 - - 0.0001326 51.0
HFD2_k127_2652051_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 472.0
HFD2_k127_2652051_5 Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 439.0
HFD2_k127_2652051_6 ATPase associated with various cellular K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 425.0
HFD2_k127_2652051_7 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 431.0
HFD2_k127_2652051_8 COG3119 Arylsulfatase A and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 416.0
HFD2_k127_2652051_9 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 372.0
HFD2_k127_2655791_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 525.0
HFD2_k127_2655791_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 508.0
HFD2_k127_2655791_10 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 323.0
HFD2_k127_2655791_11 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 312.0
HFD2_k127_2655791_12 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K21210 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 308.0
HFD2_k127_2655791_13 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 307.0
HFD2_k127_2655791_14 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 302.0
HFD2_k127_2655791_15 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 303.0
HFD2_k127_2655791_16 PFAM N-acetylneuraminic acid synthase, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 295.0
HFD2_k127_2655791_17 O-Antigen ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001443 301.0
HFD2_k127_2655791_18 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000441 285.0
HFD2_k127_2655791_19 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000154 267.0
HFD2_k127_2655791_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 465.0
HFD2_k127_2655791_20 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001718 263.0
HFD2_k127_2655791_21 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001331 259.0
HFD2_k127_2655791_22 UDP-N-acetylglucosamine 2-epimerase activity K01791,K18429 GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016787,GO:0016798,GO:0044238,GO:0071704,GO:1901576 3.2.1.184,5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000001344 249.0
HFD2_k127_2655791_23 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000002486 237.0
HFD2_k127_2655791_24 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005172 247.0
HFD2_k127_2655791_25 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000001976 229.0
HFD2_k127_2655791_26 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000611 232.0
HFD2_k127_2655791_27 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000001576 215.0
HFD2_k127_2655791_28 Cytidylyltransferase K18431 - 2.7.7.82 0.00000000000000000000000000000000000000000000000000000000001915 214.0
HFD2_k127_2655791_29 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.0000000000000000000000000000000000000000000000000000000009915 211.0
HFD2_k127_2655791_3 LPS biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 419.0
HFD2_k127_2655791_30 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067,K01790,K19997 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008831,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 1.1.1.133,5.1.3.13,5.1.3.26 0.00000000000000000000000000000000000000000000000005143 191.0
HFD2_k127_2655791_31 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000005926 154.0
HFD2_k127_2655791_32 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000806 164.0
HFD2_k127_2655791_33 biotin acetyl-CoA-carboxylase ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000007375 160.0
HFD2_k127_2655791_34 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000001495 136.0
HFD2_k127_2655791_35 Diguanylate cyclase - - - 0.0000000000000000000000000000006998 140.0
HFD2_k127_2655791_36 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.0000000000000000000000007316 115.0
HFD2_k127_2655791_37 Sigma-70 region 2 K03088 - - 0.000000000000000000000002305 112.0
HFD2_k127_2655791_38 Pfam:DUF2029 - - - 0.00000000000000000001479 98.0
HFD2_k127_2655791_39 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000001785 97.0
HFD2_k127_2655791_4 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 400.0
HFD2_k127_2655791_40 - - - - 0.00000000000001876 87.0
HFD2_k127_2655791_41 COGs COG1215 Glycosyltransferase probably involved in cell wall biogenesis - - - 0.00000000001411 68.0
HFD2_k127_2655791_42 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000001314 63.0
HFD2_k127_2655791_5 Male sterility protein K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 378.0
HFD2_k127_2655791_6 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 377.0
HFD2_k127_2655791_7 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 368.0
HFD2_k127_2655791_8 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 360.0
HFD2_k127_2655791_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 339.0
HFD2_k127_2657452_0 RES domain - - - 0.00000000000000000000000000000000000000000862 169.0
HFD2_k127_2657452_1 - - - - 0.00000000000000000003713 97.0
HFD2_k127_266988_0 Abc transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005327 285.0
HFD2_k127_266988_1 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000002795 165.0
HFD2_k127_266988_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.0000000000004392 73.0
HFD2_k127_266988_3 sequence-specific DNA binding - - - 0.0002314 52.0
HFD2_k127_2675497_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 309.0
HFD2_k127_2675497_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005156 254.0
HFD2_k127_2675497_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000004679 204.0
HFD2_k127_2675497_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000002257 138.0
HFD2_k127_2675497_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000003062 126.0
HFD2_k127_2675497_5 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000001249 85.0
HFD2_k127_2675497_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000005285 63.0
HFD2_k127_2675497_7 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000007653 50.0
HFD2_k127_2701451_0 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 426.0
HFD2_k127_2701451_1 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007967 259.0
HFD2_k127_2701451_10 WD40-like Beta Propeller Repeat - - - 0.00000000004759 76.0
HFD2_k127_2701451_11 cellular response to starvation - GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - 0.0007364 48.0
HFD2_k127_2701451_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000003293 231.0
HFD2_k127_2701451_3 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000003998 221.0
HFD2_k127_2701451_4 Ndr family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000002633 209.0
HFD2_k127_2701451_5 transcriptional regulator K07734 - - 0.00000000000000000000000000000000000000000000000000001446 198.0
HFD2_k127_2701451_6 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000009596 160.0
HFD2_k127_2701451_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000006124 157.0
HFD2_k127_2701451_8 regulatory protein, arsR - - - 0.000000000000000000000000000000000000005897 147.0
HFD2_k127_2701451_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000003223 74.0
HFD2_k127_2719663_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 460.0
HFD2_k127_2719663_1 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 460.0
HFD2_k127_2719663_10 Involved in the tonB-independent uptake of proteins - - - 0.000000003343 67.0
HFD2_k127_2719663_2 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005168 379.0
HFD2_k127_2719663_3 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 368.0
HFD2_k127_2719663_4 Branched-chain amino acid transport system / permease component K10440,K10560 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 364.0
HFD2_k127_2719663_5 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 304.0
HFD2_k127_2719663_6 transferase activity, transferring glycosyl groups K21369 - 2.4.1.270 0.0000000000000000000000000000000000000000000000000000000000003964 220.0
HFD2_k127_2719663_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000003286 118.0
HFD2_k127_2719663_8 Histidine kinase - - - 0.000000000000000000000001 121.0
HFD2_k127_2719663_9 Periplasmic component of the Tol biopolymer transport system - - - 0.0000000000000002753 89.0
HFD2_k127_2727858_0 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000005283 249.0
HFD2_k127_2727858_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000002783 220.0
HFD2_k127_2727858_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000003549 198.0
HFD2_k127_2727858_3 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000564 165.0
HFD2_k127_2727858_4 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.0000000000000000000000000000000008947 140.0
HFD2_k127_2727858_5 Glycoprotease family - - - 0.0000000000002281 81.0
HFD2_k127_2727858_6 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000009442 61.0
HFD2_k127_2727858_7 - - - - 0.00000005988 66.0
HFD2_k127_2727858_8 Carbohydrate kinase - - - 0.0001567 54.0
HFD2_k127_2747901_0 ATPase family associated with various cellular activities (AAA) K03696 - - 1.136e-203 645.0
HFD2_k127_2747901_1 Ribosomal protein S1 K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 311.0
HFD2_k127_2755581_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 496.0
HFD2_k127_2755581_1 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000008002 262.0
HFD2_k127_2755581_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000003839 168.0
HFD2_k127_2755581_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000008474 140.0
HFD2_k127_2785504_0 PFAM Enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001219 288.0
HFD2_k127_2785504_1 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000001098 259.0
HFD2_k127_2785504_10 Protein of unknown function (DUF1444) - - - 0.000008293 58.0
HFD2_k127_2785504_2 TIGRFAM phenylacetate-CoA oxygenase, PaaG subunit K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000004675 229.0
HFD2_k127_2785504_3 PFAM phenylacetic acid catabolic family protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000005455 201.0
HFD2_k127_2785504_4 Amino acid permease - - - 0.0000000000000000000000000000000000000000001339 170.0
HFD2_k127_2785504_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000002748 150.0
HFD2_k127_2785504_6 PFAM flavin reductase domain protein, FMN-binding K16048 - - 0.00000000000000000000000000000000003484 143.0
HFD2_k127_2785504_7 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000006294 148.0
HFD2_k127_2785504_8 Alpha/beta hydrolase family - - - 0.000000000000000000009526 103.0
HFD2_k127_2785504_9 Ethyl tert-butyl ether degradation - - - 0.00000001498 66.0
HFD2_k127_2798712_0 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000002318 241.0
HFD2_k127_2798712_1 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000009982 217.0
HFD2_k127_2798712_2 Protein of unknown function (DUF1706) - - - 0.00000000000000000001278 98.0
HFD2_k127_2869601_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 335.0
HFD2_k127_2869601_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000004578 248.0
HFD2_k127_2869601_2 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000003987 182.0
HFD2_k127_2869601_3 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.00001455 56.0
HFD2_k127_2869601_4 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.0009685 48.0
HFD2_k127_2937070_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 607.0
HFD2_k127_2937070_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 561.0
HFD2_k127_2937070_2 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 466.0
HFD2_k127_2937070_3 DinB superfamily - - - 0.000000000000000000000004506 119.0
HFD2_k127_2937070_4 - - - - 0.00000000000000000001579 97.0
HFD2_k127_2937070_5 amine dehydrogenase activity - - - 0.0000000000000000003223 100.0
HFD2_k127_2937070_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000007707 91.0
HFD2_k127_2937070_7 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000002056 57.0
HFD2_k127_2937575_0 Flavin containing amine oxidoreductase - - - 1.421e-234 739.0
HFD2_k127_2937575_1 Aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 454.0
HFD2_k127_2937575_2 TIGRFAM phytoene desaturase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 440.0
HFD2_k127_2937575_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 402.0
HFD2_k127_2937575_4 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 347.0
HFD2_k127_2937575_5 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000004663 250.0
HFD2_k127_2937575_6 Abc transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000004812 200.0
HFD2_k127_2937575_7 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000002432 181.0
HFD2_k127_2937575_8 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000131 132.0
HFD2_k127_2937575_9 Protein of unknown function (DUF4242) - - - 0.000000000000000000000002771 110.0
HFD2_k127_3018144_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.164e-261 816.0
HFD2_k127_3018144_1 Belongs to the formate--tetrahydrofolate ligase family K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 1.474e-217 706.0
HFD2_k127_3018144_10 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000001361 263.0
HFD2_k127_3018144_11 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000001336 220.0
HFD2_k127_3018144_12 Zn peptidase - - - 0.0000000000000000000000000000000000000000000000000005261 201.0
HFD2_k127_3018144_13 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000001649 190.0
HFD2_k127_3018144_14 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000004465 202.0
HFD2_k127_3018144_15 membrane - - - 0.00000000000000000000000000000000000000000000166 188.0
HFD2_k127_3018144_16 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000329 169.0
HFD2_k127_3018144_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000006796 155.0
HFD2_k127_3018144_18 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000001725 145.0
HFD2_k127_3018144_19 NHL repeat containing protein - - - 0.0000000000000000000000000000003884 143.0
HFD2_k127_3018144_2 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 507.0
HFD2_k127_3018144_20 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000007321 128.0
HFD2_k127_3018144_21 PFAM Formiminotransferase-cyclodeaminase - - - 0.00000000000000000000000007056 116.0
HFD2_k127_3018144_22 Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000009116 101.0
HFD2_k127_3018144_23 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000001178 102.0
HFD2_k127_3018144_24 SnoaL-like domain - - - 0.000000000000000004034 91.0
HFD2_k127_3018144_25 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000008645 83.0
HFD2_k127_3018144_26 phosphinothricin N-acetyltransferase activity - - - 0.0000008513 59.0
HFD2_k127_3018144_27 Protein of unknown function (DUF1232) - - - 0.0000595 53.0
HFD2_k127_3018144_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 449.0
HFD2_k127_3018144_4 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 446.0
HFD2_k127_3018144_5 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 399.0
HFD2_k127_3018144_6 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K14161 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 369.0
HFD2_k127_3018144_7 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 354.0
HFD2_k127_3018144_8 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005819 333.0
HFD2_k127_3018144_9 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004601 296.0
HFD2_k127_3100580_0 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000000007527 216.0
HFD2_k127_3100580_1 Histidine kinase-like ATPases K07642 - 2.7.13.3 0.000000000000000000000000000000000002866 151.0
HFD2_k127_3100580_2 PFAM Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000004965 123.0
HFD2_k127_3161170_0 PFAM ABC transporter related K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 578.0
HFD2_k127_3161170_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 392.0
HFD2_k127_3161170_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000003473 259.0
HFD2_k127_3161170_3 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000006836 243.0
HFD2_k127_3161170_4 PFAM basic membrane lipoprotein K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000125 239.0
HFD2_k127_3161170_5 PFAM basic membrane lipoprotein K07335 - - 0.00000000000000000000000000000000000000000002283 181.0
HFD2_k127_3161170_6 CoA-binding protein K06929 - - 0.0000000000000000000000000000000001603 141.0
HFD2_k127_3161170_7 lipolytic protein G-D-S-L family - - - 0.0000005871 56.0
HFD2_k127_3264370_0 AAA domain, putative AbiEii toxin, Type IV TA system K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 461.0
HFD2_k127_3264370_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 387.0
HFD2_k127_3264370_10 Uncharacterized protein conserved in bacteria (DUF2334) K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000000003202 224.0
HFD2_k127_3264370_11 Transport permease protein K09694 - - 0.0000000000000000000000000000000000000000000000000000000000002014 223.0
HFD2_k127_3264370_12 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000002662 169.0
HFD2_k127_3264370_13 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000005267 170.0
HFD2_k127_3264370_14 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000005561 140.0
HFD2_k127_3264370_15 Yqey-like protein K09117 - - 0.00000000000000000000000000002246 124.0
HFD2_k127_3264370_16 Ribosomal protein S21 K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000001032 83.0
HFD2_k127_3264370_17 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000001511 83.0
HFD2_k127_3264370_18 PAP2 superfamily K19302 - 3.6.1.27 0.00000000004377 73.0
HFD2_k127_3264370_2 7TM-HD extracellular K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 368.0
HFD2_k127_3264370_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000903 357.0
HFD2_k127_3264370_4 Transport permease protein K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 325.0
HFD2_k127_3264370_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 316.0
HFD2_k127_3264370_6 Heat shock 70 kDa protein K04043 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:0051704,GO:0098630,GO:0098743,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 299.0
HFD2_k127_3264370_7 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001439 269.0
HFD2_k127_3264370_8 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004222 258.0
HFD2_k127_3264370_9 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000001516 247.0
HFD2_k127_3279519_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.361e-220 708.0
HFD2_k127_3279519_1 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate K01576,K01652 - 2.2.1.6,4.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 627.0
HFD2_k127_3279519_2 protein-phosphocysteine-sugar phosphotransferase activity K02782,K02783 - 2.7.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000372 253.0
HFD2_k127_3279519_3 PTS system glucitol sorbitol-specific K02783 GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 - 0.0000000000000000000000000000000000000000000000000000000000000000000003786 242.0
HFD2_k127_3279519_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000003155 189.0
HFD2_k127_3279519_5 Ion channel - - - 0.0000000000000000000000000000000000000000000002148 193.0
HFD2_k127_3279519_6 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000002472 175.0
HFD2_k127_3279519_7 Xanthine dehydrogenase K00087 - 1.17.1.4 0.0000000000000397 81.0
HFD2_k127_3279519_8 Glucitol operon activator protein (GutM) K02466 - - 0.0000005232 61.0
HFD2_k127_3289735_0 PFAM alpha amylase, catalytic K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 534.0
HFD2_k127_3289735_1 Alcohol dehydrogenase GroES-like domain K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 493.0
HFD2_k127_3289735_10 PDZ domain (Also known as DHR or GLGF) - - - 0.0000000000000000000000000000000000000000000000000000008568 210.0
HFD2_k127_3289735_11 Histidine kinase K07636,K07654 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.7.13.3 0.0000000000000000000000000000000000000000000006148 187.0
HFD2_k127_3289735_12 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000001387 154.0
HFD2_k127_3289735_13 spore germination - - - 0.000000000000000000000000000000000000656 152.0
HFD2_k127_3289735_14 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000008645 104.0
HFD2_k127_3289735_15 - - - - 0.00000000000000004972 96.0
HFD2_k127_3289735_16 Protein of unknown function (DUF3105) - - - 0.0000000000000002456 90.0
HFD2_k127_3289735_17 recombinase activity K07450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000002779 85.0
HFD2_k127_3289735_18 CarboxypepD_reg-like domain K13276 - - 0.00000006399 64.0
HFD2_k127_3289735_19 - - - - 0.0000002125 63.0
HFD2_k127_3289735_2 Cys/Met metabolism PLP-dependent enzyme K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 473.0
HFD2_k127_3289735_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.00008328 46.0
HFD2_k127_3289735_21 PFAM methyltransferase - - - 0.000184 51.0
HFD2_k127_3289735_3 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 342.0
HFD2_k127_3289735_4 PFAM Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 313.0
HFD2_k127_3289735_5 Pterin binding enzyme K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 291.0
HFD2_k127_3289735_6 periplasmic binding protein LacI transcriptional regulator K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000008016 264.0
HFD2_k127_3289735_7 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000008603 271.0
HFD2_k127_3289735_8 response regulator receiver K07658,K07668 - - 0.000000000000000000000000000000000000000000000000000000000000001556 226.0
HFD2_k127_3289735_9 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000002599 226.0
HFD2_k127_3322744_0 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002083 235.0
HFD2_k127_3322744_1 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000003713 204.0
HFD2_k127_3322744_2 Adenylate cyclase regulatory domain K01768 GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005504,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009268,GO:0009628,GO:0009975,GO:0009987,GO:0010851,GO:0010854,GO:0010855,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0030234,GO:0031279,GO:0031406,GO:0033293,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098772,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0003003 53.0
HFD2_k127_333435_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 2.585e-221 704.0
HFD2_k127_333435_1 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 414.0
HFD2_k127_333435_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000004417 165.0
HFD2_k127_333435_3 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000005123 118.0
HFD2_k127_333435_4 - - - - 0.00000000000188 75.0
HFD2_k127_333435_5 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000001348 68.0
HFD2_k127_3383523_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000001001 209.0
HFD2_k127_3383523_1 - - - - 0.0000000000000000000008934 104.0
HFD2_k127_3515335_0 glutamate synthase, alpha subunit domain protein K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 7.088e-294 949.0
HFD2_k127_3515335_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 2.097e-257 810.0
HFD2_k127_3515335_10 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 438.0
HFD2_k127_3515335_11 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 417.0
HFD2_k127_3515335_12 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 383.0
HFD2_k127_3515335_13 Creatinase/Prolidase N-terminal domain K01271,K01274 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 330.0
HFD2_k127_3515335_14 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 321.0
HFD2_k127_3515335_15 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 327.0
HFD2_k127_3515335_16 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 303.0
HFD2_k127_3515335_17 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001304 293.0
HFD2_k127_3515335_18 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002481 277.0
HFD2_k127_3515335_19 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005452 274.0
HFD2_k127_3515335_2 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 3.574e-211 689.0
HFD2_k127_3515335_20 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001224 285.0
HFD2_k127_3515335_21 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001489 264.0
HFD2_k127_3515335_22 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000002286 249.0
HFD2_k127_3515335_23 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000004516 241.0
HFD2_k127_3515335_24 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000006225 233.0
HFD2_k127_3515335_25 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000002829 171.0
HFD2_k127_3515335_26 PFAM GCN5-related N-acetyltransferase K03823 - 2.3.1.183 0.000000000000000000000000000000000000000002918 169.0
HFD2_k127_3515335_27 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351,K07245 - - 0.000000000000000000000000000000000000000004201 168.0
HFD2_k127_3515335_28 cytochrome c oxidase, subunit III K02276,K02299 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.0000000000000000000000000000000000003226 162.0
HFD2_k127_3515335_29 EamA-like transporter family - - - 0.000000000000000000000000000000000001276 151.0
HFD2_k127_3515335_3 Adenylyl cyclase class-3 4 guanylyl cyclase - - - 5.656e-206 688.0
HFD2_k127_3515335_30 I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B) K02275 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.0000000000000000000000000000000002615 150.0
HFD2_k127_3515335_31 Transport permease protein K01992 - - 0.00000000000000000000000000002084 133.0
HFD2_k127_3515335_32 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K05524 - - 0.0000000000000000000000000001691 120.0
HFD2_k127_3515335_34 periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily K02199 - - 0.000000000000000000000000007881 117.0
HFD2_k127_3515335_35 ECF sigma factor K03088 - - 0.00000000000000000000002932 107.0
HFD2_k127_3515335_36 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000009769 101.0
HFD2_k127_3515335_37 PFAM CBS domain containing protein - - - 0.000000000000000007384 90.0
HFD2_k127_3515335_38 DNA-binding protein K06204 - - 0.0000000000000009873 82.0
HFD2_k127_3515335_39 Family of unknown function (DUF5317) - - - 0.0000000000004767 79.0
HFD2_k127_3515335_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 3.088e-195 632.0
HFD2_k127_3515335_41 PFAM blue (type 1) copper domain protein - - - 0.000001169 60.0
HFD2_k127_3515335_43 response regulator, receiver - - - 0.00001542 54.0
HFD2_k127_3515335_44 Polyketide cyclase / dehydrase and lipid transport - - - 0.0001131 54.0
HFD2_k127_3515335_45 - - - - 0.0001376 51.0
HFD2_k127_3515335_5 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 499.0
HFD2_k127_3515335_6 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 527.0
HFD2_k127_3515335_7 4-Hydroxyphenylpyruvate dioxygenase K00457,K16421 GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27,1.13.11.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008422 495.0
HFD2_k127_3515335_8 Required for the activity of the bacterial periplasmic transport system of putrescine K02055 GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 491.0
HFD2_k127_3515335_9 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 471.0
HFD2_k127_3536166_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 298.0
HFD2_k127_3536166_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000009966 214.0
HFD2_k127_3536166_2 Luciferase-like monooxygenase - - - 0.00000000000001631 77.0
HFD2_k127_3549502_0 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 423.0
HFD2_k127_3549502_1 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 347.0
HFD2_k127_3549502_10 Domain of unknown function (DUF4349) - - - 0.00000000000000000000009421 111.0
HFD2_k127_3549502_11 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000111 114.0
HFD2_k127_3549502_12 COG3209 Rhs family protein - - - 0.00000000000002699 88.0
HFD2_k127_3549502_13 Protein of unknown function (DUF2630) - - - 0.0000000005633 67.0
HFD2_k127_3549502_14 cellulase activity K01224,K07004,K10440,K14274,K20276,K21449 - 3.2.1.89 0.000000001252 72.0
HFD2_k127_3549502_2 Binding-protein-dependent transport system inner membrane component K17317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000084 325.0
HFD2_k127_3549502_3 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000001705 245.0
HFD2_k127_3549502_4 Magnesium transport protein CorA K03284 - - 0.0000000000000000000000000000000000000000000003067 182.0
HFD2_k127_3549502_5 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000002614 169.0
HFD2_k127_3549502_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000652 136.0
HFD2_k127_3549502_7 DNA binding domain - - - 0.000000000000000000000000001218 119.0
HFD2_k127_3549502_8 WD40 domain protein beta Propeller K03641 - - 0.000000000000000000000000001427 121.0
HFD2_k127_3549502_9 Transcriptional regulator PadR-like family - - - 0.00000000000000000000001069 104.0
HFD2_k127_355754_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 344.0
HFD2_k127_355754_1 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000006507 214.0
HFD2_k127_355754_2 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000237 194.0
HFD2_k127_355754_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000001048 164.0
HFD2_k127_3575825_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1167.0
HFD2_k127_3575825_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 2.3e-201 654.0
HFD2_k127_3575825_10 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 445.0
HFD2_k127_3575825_11 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 423.0
HFD2_k127_3575825_12 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 409.0
HFD2_k127_3575825_13 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 428.0
HFD2_k127_3575825_14 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 419.0
HFD2_k127_3575825_15 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 398.0
HFD2_k127_3575825_16 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 402.0
HFD2_k127_3575825_17 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 379.0
HFD2_k127_3575825_18 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 366.0
HFD2_k127_3575825_19 Belongs to the GARS family K01945,K11788 GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 338.0
HFD2_k127_3575825_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 586.0
HFD2_k127_3575825_20 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 333.0
HFD2_k127_3575825_21 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 309.0
HFD2_k127_3575825_22 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 294.0
HFD2_k127_3575825_23 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006677 291.0
HFD2_k127_3575825_24 PFAM AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000131 297.0
HFD2_k127_3575825_25 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000021 270.0
HFD2_k127_3575825_26 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002659 262.0
HFD2_k127_3575825_27 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000001259 234.0
HFD2_k127_3575825_28 ABC-type dipeptide oligopeptide nickel transport K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000001785 232.0
HFD2_k127_3575825_29 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000002471 213.0
HFD2_k127_3575825_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 561.0
HFD2_k127_3575825_30 ABC transporter substrate-binding protein K02035 - - 0.00000000000000000000000000000000000000000000000000007228 210.0
HFD2_k127_3575825_31 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000001527 168.0
HFD2_k127_3575825_32 Rossmann-like domain - - - 0.00000000000000000000000000000000000000000003731 173.0
HFD2_k127_3575825_33 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000000000001728 171.0
HFD2_k127_3575825_34 NUDIX domain - - - 0.000000000000000000000000000000001269 139.0
HFD2_k127_3575825_35 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000004139 127.0
HFD2_k127_3575825_36 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000006901 119.0
HFD2_k127_3575825_37 Protein of unknown function (DUF1290) - - - 0.00000000000000000000000001154 112.0
HFD2_k127_3575825_38 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000001587 78.0
HFD2_k127_3575825_39 YGGT family K02221 - - 0.0000000000002782 72.0
HFD2_k127_3575825_4 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 504.0
HFD2_k127_3575825_40 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000209 77.0
HFD2_k127_3575825_41 Belongs to the UPF0235 family K09131 - - 0.00000000002098 75.0
HFD2_k127_3575825_42 peptidase - - - 0.000000992 61.0
HFD2_k127_3575825_43 POTRA domain, FtsQ-type K03589 - - 0.00004358 55.0
HFD2_k127_3575825_5 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008414 460.0
HFD2_k127_3575825_6 bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 462.0
HFD2_k127_3575825_7 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000872 448.0
HFD2_k127_3575825_8 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 435.0
HFD2_k127_3575825_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 433.0
HFD2_k127_3631717_0 FAD dependent oxidoreductase central domain - - - 5e-324 1012.0
HFD2_k127_3631717_1 FAD dependent oxidoreductase central domain K19191 - 1.5.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 432.0
HFD2_k127_3631717_10 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000004491 148.0
HFD2_k127_3631717_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000005819 115.0
HFD2_k127_3631717_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 377.0
HFD2_k127_3631717_3 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 317.0
HFD2_k127_3631717_4 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007391 274.0
HFD2_k127_3631717_5 Choline ethanolamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004187 265.0
HFD2_k127_3631717_6 TIGRFAM competence damage-inducible protein CinA N-terminal domain K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000001591 255.0
HFD2_k127_3631717_7 PFAM Inositol monophosphatase K01092,K05602 - 3.1.3.15,3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000034 222.0
HFD2_k127_3631717_8 Clp protease K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000004123 200.0
HFD2_k127_3631717_9 - - - - 0.00000000000000000000000000000000000002414 153.0
HFD2_k127_3636092_0 Alpha amylase, catalytic domain - - - 6.554e-251 809.0
HFD2_k127_3636092_1 Carbohydrate phosphorylase K00688,K00691 - 2.4.1.1,2.4.1.8 5.51e-198 640.0
HFD2_k127_3636092_10 UbiC transcription regulator-associated domain protein K03710 - - 0.000001232 60.0
HFD2_k127_3636092_2 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008896 560.0
HFD2_k127_3636092_3 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 414.0
HFD2_k127_3636092_4 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009953 333.0
HFD2_k127_3636092_5 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000007696 186.0
HFD2_k127_3636092_6 PASTA domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000009163 181.0
HFD2_k127_3636092_7 PFAM Cupin 2, conserved barrel - - - 0.0000000000000000000000002143 115.0
HFD2_k127_3636092_8 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000004482 117.0
HFD2_k127_3636092_9 PFAM amino acid-binding ACT domain protein - - - 0.00000000001805 73.0
HFD2_k127_3682282_0 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000108 239.0
HFD2_k127_3682282_1 PHP domain protein K07053 - 3.1.3.97 0.00000000000000000000000000000000001124 146.0
HFD2_k127_3698565_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 1.465e-296 929.0
HFD2_k127_3698565_1 Histidine kinase - - - 0.000000000000000000000001932 117.0
HFD2_k127_3703076_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.613e-229 721.0
HFD2_k127_3703076_1 TatD family K03424 - - 0.000000000000000000000000000000000000000001908 168.0
HFD2_k127_3703076_2 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000001178 166.0
HFD2_k127_3703076_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000003766 142.0
HFD2_k127_3703076_4 ECF sigma factor K03088 - - 0.0000000000000000000000000001631 122.0
HFD2_k127_3703076_5 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000002505 86.0
HFD2_k127_3703076_6 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000002858 83.0
HFD2_k127_3715814_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 4.289e-316 978.0
HFD2_k127_3715814_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 486.0
HFD2_k127_3715814_10 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 332.0
HFD2_k127_3715814_11 abc transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005764 304.0
HFD2_k127_3715814_12 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000001424 278.0
HFD2_k127_3715814_13 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000001499 235.0
HFD2_k127_3715814_14 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000001322 210.0
HFD2_k127_3715814_15 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000006795 205.0
HFD2_k127_3715814_16 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000008511 179.0
HFD2_k127_3715814_17 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000002202 177.0
HFD2_k127_3715814_18 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000005112 166.0
HFD2_k127_3715814_19 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000006439 172.0
HFD2_k127_3715814_2 Helix-hairpin-helix DNA-binding, class 1 K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009173 494.0
HFD2_k127_3715814_20 cell envelope-related transcriptional attenuator - - - 0.00000000000000000000000000000000000007078 160.0
HFD2_k127_3715814_21 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000002431 129.0
HFD2_k127_3715814_22 PFAM Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000004875 134.0
HFD2_k127_3715814_23 LysE type translocator - - - 0.00000000000000000000000003261 117.0
HFD2_k127_3715814_24 cyclic nucleotide binding K09766,K10914 - - 0.00000000000000000002661 99.0
HFD2_k127_3715814_25 Glucose / Sorbosone dehydrogenase - - - 0.000000000002757 80.0
HFD2_k127_3715814_26 Activator of hsp90 atpase 1 family protein - - - 0.0000000003101 72.0
HFD2_k127_3715814_27 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000003888 61.0
HFD2_k127_3715814_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 494.0
HFD2_k127_3715814_4 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 446.0
HFD2_k127_3715814_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 436.0
HFD2_k127_3715814_6 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 383.0
HFD2_k127_3715814_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 376.0
HFD2_k127_3715814_8 Sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 354.0
HFD2_k127_3715814_9 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 317.0
HFD2_k127_3735156_0 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000009213 138.0
HFD2_k127_3735156_1 ATP synthase F(0) sector subunit b K02109 - - 0.00000000000000000001048 99.0
HFD2_k127_3735156_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000379 63.0
HFD2_k127_3735156_3 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00001268 56.0
HFD2_k127_3746198_0 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 472.0
HFD2_k127_3746198_1 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 403.0
HFD2_k127_3746198_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000003067 264.0
HFD2_k127_3746198_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000002092 256.0
HFD2_k127_3746198_4 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000006075 234.0
HFD2_k127_3746198_5 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000002697 119.0
HFD2_k127_3746198_6 glutamate synthase, alpha subunit domain protein K00284 - 1.4.7.1 0.0000000000000000000000008516 110.0
HFD2_k127_3746198_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000281 98.0
HFD2_k127_3746198_8 ATP-binding region, ATPase domain protein - - - 0.00000000000002967 86.0
HFD2_k127_3818959_0 succinate dehydrogenase K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 4.422e-227 732.0
HFD2_k127_3818959_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 6.177e-208 657.0
HFD2_k127_3818959_10 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001616 286.0
HFD2_k127_3818959_11 Penicillin-binding Protein dimerisation domain K03587,K08384 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000002011 261.0
HFD2_k127_3818959_12 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000002069 245.0
HFD2_k127_3818959_13 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000007561 257.0
HFD2_k127_3818959_14 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000361 149.0
HFD2_k127_3818959_15 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000001243 142.0
HFD2_k127_3818959_16 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000002732 137.0
HFD2_k127_3818959_17 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.00000000000000000000000000000005395 139.0
HFD2_k127_3818959_18 phosphoglycerate mutase K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.0000000000000000000000000002309 122.0
HFD2_k127_3818959_19 IstB-like ATP binding protein - - - 0.00000000000000000000001876 108.0
HFD2_k127_3818959_2 PFAM isocitrate isopropylmalate dehydrogenase K00030,K07246 - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 486.0
HFD2_k127_3818959_20 META domain - - - 0.0002536 52.0
HFD2_k127_3818959_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 372.0
HFD2_k127_3818959_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 376.0
HFD2_k127_3818959_5 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 353.0
HFD2_k127_3818959_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 350.0
HFD2_k127_3818959_7 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 338.0
HFD2_k127_3818959_8 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 312.0
HFD2_k127_3818959_9 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005114 302.0
HFD2_k127_3834120_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000789 290.0
HFD2_k127_3834120_1 TIGRFAM Translation elongation factor K02355 - - 0.00000000000000000000000000000000000000000000000000000000000004009 217.0
HFD2_k127_3834120_2 Permeases of the drug metabolite transporter DMT superfamily - - - 0.0000000000000000000000000008381 113.0
HFD2_k127_3868377_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000007543 228.0
HFD2_k127_3868377_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000007821 213.0
HFD2_k127_3868377_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000002825 192.0
HFD2_k127_3868377_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000007796 98.0
HFD2_k127_3868377_4 N-acetylglucosaminylinositol deacetylase activity - - - 0.00000000000000001934 94.0
HFD2_k127_3868377_5 Acetylglucosaminylphosphatidylinositol deacetylase - - - 0.0005669 51.0
HFD2_k127_3885513_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.614e-224 733.0
HFD2_k127_3885513_1 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 468.0
HFD2_k127_3885513_10 Asparaginase - - - 0.0000009344 50.0
HFD2_k127_3885513_2 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 441.0
HFD2_k127_3885513_3 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 346.0
HFD2_k127_3885513_4 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004179 253.0
HFD2_k127_3885513_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.0000000000000000000000000000000000000000000000000000001571 203.0
HFD2_k127_3885513_6 2 iron, 2 sulfur cluster binding K03518,K07302 - 1.2.5.3,1.3.99.16 0.0000000000000000000000000000000000000000000000000003545 196.0
HFD2_k127_3885513_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000006594 190.0
HFD2_k127_3885513_8 carbon monoxide dehydrogenase subunit G K09386 - - 0.000000000000000001198 95.0
HFD2_k127_3885513_9 membrane transporter protein K07090 - - 0.00000000000003295 87.0
HFD2_k127_3903512_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.774e-229 717.0
HFD2_k127_3903512_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 624.0
HFD2_k127_3903512_10 Prephenate dehydratase K04518,K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000006645 233.0
HFD2_k127_3903512_11 ACT domain K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000009461 186.0
HFD2_k127_3903512_12 Colicin V production protein - - - 0.00000000000000000000000000000000000000005036 167.0
HFD2_k127_3903512_13 Domain of unknown function (DUF4332) - - - 0.000000000000000000000000000000001014 136.0
HFD2_k127_3903512_14 YCII-related domain - - - 0.000000000000000000000000000000001932 134.0
HFD2_k127_3903512_15 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000003846 121.0
HFD2_k127_3903512_16 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000006746 67.0
HFD2_k127_3903512_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 597.0
HFD2_k127_3903512_3 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 526.0
HFD2_k127_3903512_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 500.0
HFD2_k127_3903512_5 belongs to the sigma-70 factor family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 484.0
HFD2_k127_3903512_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000085 436.0
HFD2_k127_3903512_7 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 402.0
HFD2_k127_3903512_8 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 335.0
HFD2_k127_3903512_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000003403 230.0
HFD2_k127_3903795_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.419e-289 912.0
HFD2_k127_3903795_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 1.785e-268 841.0
HFD2_k127_3903795_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 407.0
HFD2_k127_3903795_3 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001358 260.0
HFD2_k127_3903795_4 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000003692 191.0
HFD2_k127_3903795_5 thiolester hydrolase activity K03186 - 2.5.1.129 0.000000000000000000000003722 110.0
HFD2_k127_3903795_6 DNA alkylation repair enzyme - - - 0.000002175 60.0
HFD2_k127_4004316_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 2.812e-211 673.0
HFD2_k127_4004316_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 488.0
HFD2_k127_4004316_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.00001109 55.0
HFD2_k127_4004316_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 376.0
HFD2_k127_4004316_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 306.0
HFD2_k127_4004316_4 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000303 247.0
HFD2_k127_4004316_5 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007434 250.0
HFD2_k127_4004316_6 cyclic nucleotide binding K10914 - - 0.000000000000000000000000009932 118.0
HFD2_k127_4004316_7 transcriptional regulator K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.00000000000000005347 88.0
HFD2_k127_4004316_8 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000444 67.0
HFD2_k127_4004316_9 PFAM thioesterase superfamily protein K07107 - - 0.000009161 49.0
HFD2_k127_4008418_0 Baseplate J-like protein - - - 1.53e-240 764.0
HFD2_k127_4008418_1 Phage tail sheath C-terminal domain K06907 - - 1.171e-218 691.0
HFD2_k127_4008418_10 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002954 278.0
HFD2_k127_4008418_11 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001331 261.0
HFD2_k127_4008418_12 Branched-chain amino acid transport system / permease component K10439,K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003539 254.0
HFD2_k127_4008418_13 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000008754 244.0
HFD2_k127_4008418_14 Bacterial regulatory proteins, luxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000002557 239.0
HFD2_k127_4008418_15 Protein of unknown function (DUF4255) - - - 0.000000000000000000000000000000000000000000000000000000000000001055 231.0
HFD2_k127_4008418_16 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain K03520,K11177 - 1.17.1.4,1.2.5.3 0.0000000000000000000000000000000000000000000000000000001505 198.0
HFD2_k127_4008418_17 - - - - 0.00000000000000000000000000000000000000000000000000000336 193.0
HFD2_k127_4008418_18 Phage baseplate assembly protein W K06903 - - 0.000000000000000000000000000000000000000000000000003272 191.0
HFD2_k127_4008418_19 Phage tail protein (Tail_P2_I) - - - 0.00000000000000000000000000000000000000000000000203 184.0
HFD2_k127_4008418_2 PFAM AAA ATPase central domain protein - - - 4.704e-197 644.0
HFD2_k127_4008418_20 PFAM Peptidoglycan-binding - - - 0.00000000000000000000000000000000000000001188 163.0
HFD2_k127_4008418_21 asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000004844 162.0
HFD2_k127_4008418_22 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000005434 153.0
HFD2_k127_4008418_23 regulatory protein GntR HTH - - - 0.000000000000000000000000000000000002863 154.0
HFD2_k127_4008418_24 phage tail protein - - - 0.00000000000000000000000000000000008208 137.0
HFD2_k127_4008418_25 Zinc finger domain - - - 0.0000000000000000000000000000001188 143.0
HFD2_k127_4008418_26 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000001829 132.0
HFD2_k127_4008418_27 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.000000000000000000000000000128 123.0
HFD2_k127_4008418_28 ABC-type sugar transport system periplasmic component K03549,K10439,K10910,K21429 GO:0006355,GO:0006810,GO:0008150,GO:0008643,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0060255,GO:0065007,GO:0071702,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000001492 129.0
HFD2_k127_4008418_29 PAS domain - - - 0.00000000000000000000001231 108.0
HFD2_k127_4008418_3 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 520.0
HFD2_k127_4008418_30 PAAR motif - - - 0.000000000000000000001389 104.0
HFD2_k127_4008418_31 Domain of unknown function (DUF296) - - - 0.000000000000000008884 93.0
HFD2_k127_4008418_32 WD40-like Beta Propeller Repeat - - - 0.00000000000000009528 93.0
HFD2_k127_4008418_33 - - - - 0.0000000000000005805 84.0
HFD2_k127_4008418_34 Domain of unknown function (DUF4157) - - - 0.000000000001562 81.0
HFD2_k127_4008418_4 PFAM transcriptional regulator domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 526.0
HFD2_k127_4008418_5 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 460.0
HFD2_k127_4008418_6 PFAM isocitrate isopropylmalate dehydrogenase K00052,K07246 - 1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 427.0
HFD2_k127_4008418_7 Rhs element Vgr protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 372.0
HFD2_k127_4008418_8 import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008605 363.0
HFD2_k127_4008418_9 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001228 291.0
HFD2_k127_4069401_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 526.0
HFD2_k127_4069401_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000005329 141.0
HFD2_k127_4069401_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000001714 130.0
HFD2_k127_4111757_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 385.0
HFD2_k127_4111757_1 Anticodon-binding domain of tRNA K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 316.0
HFD2_k127_4111757_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002495 291.0
HFD2_k127_4111757_3 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000005754 187.0
HFD2_k127_4111757_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000009649 105.0
HFD2_k127_419692_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.121e-235 752.0
HFD2_k127_419692_1 Type II/IV secretion system protein K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 545.0
HFD2_k127_419692_2 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000001588 147.0
HFD2_k127_419692_3 Sigma-70, region 4 K03088 - - 0.0000000000000000001889 96.0
HFD2_k127_431210_0 Sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002006 285.0
HFD2_k127_431210_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000002263 162.0
HFD2_k127_431210_2 Acetyltransferase (GNAT) domain - - - 0.000000000001159 81.0
HFD2_k127_431210_3 phosphatidylinositol metabolic process K13671 - - 0.000004128 59.0
HFD2_k127_431210_4 O-Antigen ligase - - - 0.0001988 55.0
HFD2_k127_4390181_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1032.0
HFD2_k127_4390181_1 PERMEase K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 605.0
HFD2_k127_4390181_10 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000009305 189.0
HFD2_k127_4390181_11 Acid phosphatase homologues - - - 0.0000000000000000000000000000000000000000000001654 176.0
HFD2_k127_4390181_12 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000001795 175.0
HFD2_k127_4390181_13 Major Facilitator Superfamily - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000002235 167.0
HFD2_k127_4390181_14 Oxidoreductase NAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000003946 159.0
HFD2_k127_4390181_15 Xanthine uracil vitamin C permease K06901 - - 0.00000000000000000000000000000000000004718 149.0
HFD2_k127_4390181_16 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000002393 146.0
HFD2_k127_4390181_17 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000001293 129.0
HFD2_k127_4390181_18 acetyltransferase K06975 - - 0.0000000000000000001556 93.0
HFD2_k127_4390181_19 Transglycosylase associated protein - - - 0.00000000000000002458 87.0
HFD2_k127_4390181_2 Succinyl-CoA synthetase, alpha subunit K02381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 530.0
HFD2_k127_4390181_20 Protein of unknown function (DUF2877) - - - 0.0000000000000004749 89.0
HFD2_k127_4390181_21 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000005229 83.0
HFD2_k127_4390181_3 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 455.0
HFD2_k127_4390181_4 spermidine synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 458.0
HFD2_k127_4390181_5 FdrA family K02381 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 405.0
HFD2_k127_4390181_6 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 352.0
HFD2_k127_4390181_7 PFAM Purine catabolism regulatory protein-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 333.0
HFD2_k127_4390181_8 oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 319.0
HFD2_k127_4390181_9 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 313.0
HFD2_k127_4415172_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 462.0
HFD2_k127_4415172_1 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 414.0
HFD2_k127_4415172_10 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000009277 190.0
HFD2_k127_4415172_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 3.1.26.3 0.0000000000000000000000000000000000000000000001108 177.0
HFD2_k127_4415172_12 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000007667 169.0
HFD2_k127_4415172_13 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000001995 163.0
HFD2_k127_4415172_14 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000001081 146.0
HFD2_k127_4415172_15 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000004887 113.0
HFD2_k127_4415172_16 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000002396 112.0
HFD2_k127_4415172_17 RNA methyltransferase, RsmD family K08316 - 2.1.1.171 0.000000000000000000000002116 110.0
HFD2_k127_4415172_18 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000007341 103.0
HFD2_k127_4415172_19 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000002159 109.0
HFD2_k127_4415172_2 PFAM Dak phosphatase K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 345.0
HFD2_k127_4415172_20 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000002603 102.0
HFD2_k127_4415172_21 Belongs to the UPF0109 family K06960 - - 0.0000000000000000002145 94.0
HFD2_k127_4415172_22 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - 0.0000000000000000003954 95.0
HFD2_k127_4415172_23 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000001475 84.0
HFD2_k127_4415172_24 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000664 88.0
HFD2_k127_4415172_25 Protein conserved in bacteria - - - 0.00000596 55.0
HFD2_k127_4415172_26 Protein of unknown function (DUF3352) - - - 0.00002396 58.0
HFD2_k127_4415172_27 Ribosomal L28 family K02902 - - 0.00002967 53.0
HFD2_k127_4415172_28 Asp23 family, cell envelope-related function - - - 0.0007702 51.0
HFD2_k127_4415172_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 306.0
HFD2_k127_4415172_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 295.0
HFD2_k127_4415172_5 RecF/RecN/SMC N terminal domain K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 321.0
HFD2_k127_4415172_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001158 291.0
HFD2_k127_4415172_7 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000001042 261.0
HFD2_k127_4415172_8 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000008518 212.0
HFD2_k127_4415172_9 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000004094 191.0
HFD2_k127_4426899_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 364.0
HFD2_k127_4426899_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 345.0
HFD2_k127_4426899_2 Cys Met metabolism K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 316.0
HFD2_k127_4426899_3 diguanylate cyclase - - - 0.0000000000000000000000000000000000000005532 167.0
HFD2_k127_4426899_4 Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions K02635 GO:0005575,GO:0005622,GO:0005623,GO:0009512,GO:0009579,GO:0016020,GO:0032991,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464,GO:0070069 - 0.0000000000000000000000006023 117.0
HFD2_k127_4426899_5 cytochrome c biogenesis protein K07399 - - 0.00000000000000000000000216 114.0
HFD2_k127_4431327_0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1322.0
HFD2_k127_4431327_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 8.087e-216 688.0
HFD2_k127_4431327_10 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 392.0
HFD2_k127_4431327_11 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 334.0
HFD2_k127_4431327_12 histidine kinase dimerisation and phosphoacceptor region K03406,K07673,K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001022 291.0
HFD2_k127_4431327_13 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001087 285.0
HFD2_k127_4431327_14 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000741 276.0
HFD2_k127_4431327_15 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000791 244.0
HFD2_k127_4431327_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001828 230.0
HFD2_k127_4431327_17 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000002873 220.0
HFD2_k127_4431327_18 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.00000000000000000000000000000000000000000000007028 182.0
HFD2_k127_4431327_19 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000002602 169.0
HFD2_k127_4431327_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 1.743e-194 621.0
HFD2_k127_4431327_20 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000002811 163.0
HFD2_k127_4431327_21 AAA ATPase domain - - - 0.0000000000000000000000000003272 133.0
HFD2_k127_4431327_22 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000001301 109.0
HFD2_k127_4431327_23 Sulfurtransferase TusA - - - 0.0000000000000000000001015 100.0
HFD2_k127_4431327_24 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000003501 89.0
HFD2_k127_4431327_25 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000002403 82.0
HFD2_k127_4431327_26 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000273 85.0
HFD2_k127_4431327_27 Transcriptional regulator - - - 0.0000000000000008657 86.0
HFD2_k127_4431327_28 Universal stress protein family - GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016208,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000001613 80.0
HFD2_k127_4431327_29 HupF/HypC family K04653 - - 0.000000008114 61.0
HFD2_k127_4431327_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K00823 - 2.6.1.19,4.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007396 530.0
HFD2_k127_4431327_30 spore germination K03605 - - 0.000004775 59.0
HFD2_k127_4431327_4 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 527.0
HFD2_k127_4431327_5 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 508.0
HFD2_k127_4431327_6 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 461.0
HFD2_k127_4431327_7 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 450.0
HFD2_k127_4431327_8 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 434.0
HFD2_k127_4431327_9 Acetokinase family K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 395.0
HFD2_k127_4443235_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 370.0
HFD2_k127_4443235_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 355.0
HFD2_k127_4443235_2 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 306.0
HFD2_k127_4443235_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000791 249.0
HFD2_k127_4443235_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000007342 220.0
HFD2_k127_4443235_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000735 202.0
HFD2_k127_4443235_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000001563 181.0
HFD2_k127_4443235_7 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000001309 153.0
HFD2_k127_4443235_8 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000002403 153.0
HFD2_k127_4443235_9 Pyridoxamine 5'-phosphate oxidase - - - 0.000000000000000000000002744 111.0
HFD2_k127_4462954_0 MMPL family K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 515.0
HFD2_k127_4462954_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 372.0
HFD2_k127_4462954_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 330.0
HFD2_k127_4462954_3 - - - - 0.0000000000000000000000000000000000000000000018 171.0
HFD2_k127_4462954_5 - - - - 0.00000000013 63.0
HFD2_k127_4464467_0 DNA primase, small subunit K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 612.0
HFD2_k127_4464467_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 376.0
HFD2_k127_4464467_11 Urate oxidase N-terminal - - - 0.00002097 54.0
HFD2_k127_4464467_12 ATP-binding protein K11710 - - 0.00008191 48.0
HFD2_k127_4464467_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002564 260.0
HFD2_k127_4464467_3 ABC 3 transport family K09819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003506 256.0
HFD2_k127_4464467_4 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000005139 223.0
HFD2_k127_4464467_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000683 225.0
HFD2_k127_4464467_6 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000004925 134.0
HFD2_k127_4464467_7 AI-2E family transporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000001508 117.0
HFD2_k127_4464467_8 - - - - 0.000000000000000000000001849 109.0
HFD2_k127_4464467_9 Polyketide cyclase / dehydrase and lipid transport - - - 0.00001312 55.0
HFD2_k127_4471939_0 TIGRFAM histidinol phosphate phosphatase HisJ family K04486 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15 0.00000000000000000000000000000000000000007361 163.0
HFD2_k127_4471939_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000005856 136.0
HFD2_k127_4495975_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 559.0
HFD2_k127_4495975_1 TrkA-N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 455.0
HFD2_k127_4495975_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000002181 199.0
HFD2_k127_4495975_11 PFAM YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000000007244 162.0
HFD2_k127_4495975_12 lysozyme - - - 0.0000000000000000000000000000000000008578 155.0
HFD2_k127_4495975_13 NADP transhydrogenase K00324 - 1.6.1.2 0.000000000000000000000000000001144 138.0
HFD2_k127_4495975_14 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000002168 126.0
HFD2_k127_4495975_15 AAA ATPase domain - - - 0.0000000000002282 80.0
HFD2_k127_4495975_2 PFAM alanine dehydrogenase PNT domain protein K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008036 419.0
HFD2_k127_4495975_3 Belongs to the N(4) N(6)-methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 344.0
HFD2_k127_4495975_4 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 330.0
HFD2_k127_4495975_5 Threonyl alanyl tRNA synthetase SAD K01872,K07050 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000003791 260.0
HFD2_k127_4495975_6 Glycosyl transferase, family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008269 251.0
HFD2_k127_4495975_7 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000003459 251.0
HFD2_k127_4495975_8 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00000000000000000000000000000000000000000000000000000000000000001087 237.0
HFD2_k127_4495975_9 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000002026 195.0
HFD2_k127_4526602_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 4.344e-232 732.0
HFD2_k127_4526602_1 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 538.0
HFD2_k127_4526602_10 Cellulose biosynthesis protein BcsQ K03496 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000006745 233.0
HFD2_k127_4526602_11 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000000000000000000000000000000000000000005752 234.0
HFD2_k127_4526602_12 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000002556 186.0
HFD2_k127_4526602_13 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000000000000000008052 187.0
HFD2_k127_4526602_14 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000001794 168.0
HFD2_k127_4526602_15 PFAM Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.000000000000000000000000000006836 123.0
HFD2_k127_4526602_16 regulation of RNA biosynthetic process - - - 0.00000000000000000000000000007569 123.0
HFD2_k127_4526602_17 RDD family - - - 0.000000000000000000000000002372 123.0
HFD2_k127_4526602_18 PFAM Phospholipid glycerol acyltransferase - - - 0.00000000000000000000004747 113.0
HFD2_k127_4526602_19 ACT domain protein - - - 0.000000000000000000004849 102.0
HFD2_k127_4526602_2 Mo-co oxidoreductase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 496.0
HFD2_k127_4526602_20 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000002878 103.0
HFD2_k127_4526602_21 F420H(2)-dependent quinone reductase - - - 0.000000000000000002113 101.0
HFD2_k127_4526602_22 UbiA prenyltransferase family - - - 0.000000000000000005925 94.0
HFD2_k127_4526602_23 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000005817 88.0
HFD2_k127_4526602_24 PspC domain K03973 - - 0.00000000000004585 81.0
HFD2_k127_4526602_25 Biotin-requiring enzyme - - - 0.00000000006004 76.0
HFD2_k127_4526602_26 membrane - - - 0.000002526 59.0
HFD2_k127_4526602_27 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0003393 50.0
HFD2_k127_4526602_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 437.0
HFD2_k127_4526602_4 Carbamoyl-phosphate synthetase large chain domain protein K01968 - 6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008951 413.0
HFD2_k127_4526602_5 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 336.0
HFD2_k127_4526602_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 316.0
HFD2_k127_4526602_7 TPM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001234 286.0
HFD2_k127_4526602_8 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005143 256.0
HFD2_k127_4526602_9 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000001656 238.0
HFD2_k127_4533927_0 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000009699 271.0
HFD2_k127_4533927_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000004841 146.0
HFD2_k127_4545908_0 PFAM Uncharacterised protein family UPF0182 K09118 - - 6.655e-200 659.0
HFD2_k127_4545908_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 580.0
HFD2_k127_4545908_10 Bacterial transferase hexapeptide - - - 0.000000000000000000000000000000000000000000000000001929 195.0
HFD2_k127_4545908_11 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000000000002494 195.0
HFD2_k127_4545908_12 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000002394 177.0
HFD2_k127_4545908_13 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000003417 149.0
HFD2_k127_4545908_14 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000002976 128.0
HFD2_k127_4545908_15 Double zinc ribbon - - - 0.00000000000000000000001879 108.0
HFD2_k127_4545908_16 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000006831 109.0
HFD2_k127_4545908_17 Putative lumazine-binding - - - 0.0000000000000000006631 94.0
HFD2_k127_4545908_18 transferase activity, transferring glycosyl groups - - - 0.0000000000000001465 93.0
HFD2_k127_4545908_19 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K03525 - 2.7.1.33 0.00000000001426 78.0
HFD2_k127_4545908_2 Cell division protein FtsA K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009547 454.0
HFD2_k127_4545908_20 Glycosyl transferases group 1 - - - 0.000000000399 74.0
HFD2_k127_4545908_21 O-antigen - - - 0.0000002783 63.0
HFD2_k127_4545908_22 CAAX protease self-immunity K07052 - - 0.00001147 57.0
HFD2_k127_4545908_23 signal transduction histidine kinase - - - 0.00001966 52.0
HFD2_k127_4545908_3 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 376.0
HFD2_k127_4545908_4 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000846 355.0
HFD2_k127_4545908_5 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 307.0
HFD2_k127_4545908_6 PFAM Glycosyl transferase family 2 K16557 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002434 268.0
HFD2_k127_4545908_7 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000001298 251.0
HFD2_k127_4545908_8 PFAM oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002388 248.0
HFD2_k127_4545908_9 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000002083 235.0
HFD2_k127_4620592_0 Asparagine synthase K01953 - 6.3.5.4 1.35e-226 718.0
HFD2_k127_4620592_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 394.0
HFD2_k127_4620592_2 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 373.0
HFD2_k127_4620592_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 343.0
HFD2_k127_4620592_4 transferase activity, transferring glycosyl groups K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000178 239.0
HFD2_k127_4643665_0 Carbamoyl-phosphate synthase K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 2.024e-284 915.0
HFD2_k127_4643665_1 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 442.0
HFD2_k127_4643665_10 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000005535 76.0
HFD2_k127_4643665_11 PFAM TadE family protein - - - 0.00000004685 62.0
HFD2_k127_4643665_2 MMPL family K06994,K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004439 425.0
HFD2_k127_4643665_3 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 352.0
HFD2_k127_4643665_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 339.0
HFD2_k127_4643665_5 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000002432 221.0
HFD2_k127_4643665_6 polysaccharide deacetylase - - - 0.00000000000000000000000000003957 131.0
HFD2_k127_4643665_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000002683 98.0
HFD2_k127_4643665_8 Right handed beta helix region - - - 0.00000000000000001626 94.0
HFD2_k127_4643665_9 Belongs to the 'phage' integrase family - - - 0.000000000000009259 81.0
HFD2_k127_471490_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 535.0
HFD2_k127_471490_1 aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000001512 156.0
HFD2_k127_471490_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000002383 88.0
HFD2_k127_4873442_0 helix_turn_helix, cAMP Regulatory protein K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.0000000000000000000000000000000000000000584 160.0
HFD2_k127_4873442_1 Transmembrane secretion effector - - - 0.00000000000000000000000000001899 137.0
HFD2_k127_4873442_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000615 110.0
HFD2_k127_4873442_3 PFAM thioesterase superfamily protein K07107 - - 0.000000000000000000001133 101.0
HFD2_k127_4873442_4 Cyclic nucleotide-monophosphate binding domain K04739 GO:0000086,GO:0000166,GO:0000278,GO:0000902,GO:0000904,GO:0001664,GO:0001674,GO:0001932,GO:0001933,GO:0001934,GO:0003008,GO:0003014,GO:0003091,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0005952,GO:0006082,GO:0006469,GO:0006629,GO:0006631,GO:0006928,GO:0006935,GO:0006950,GO:0006996,GO:0007049,GO:0007154,GO:0007165,GO:0007275,GO:0007346,GO:0007399,GO:0007409,GO:0007411,GO:0007596,GO:0007599,GO:0007610,GO:0007611,GO:0007612,GO:0007622,GO:0007623,GO:0007626,GO:0008150,GO:0008152,GO:0008603,GO:0009410,GO:0009605,GO:0009611,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010389,GO:0010562,GO:0010563,GO:0010564,GO:0010604,GO:0010605,GO:0010720,GO:0014070,GO:0015630,GO:0016020,GO:0016043,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019752,GO:0019866,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022008,GO:0022402,GO:0022406,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030104,GO:0030154,GO:0030182,GO:0030234,GO:0030291,GO:0030315,GO:0030425,GO:0030534,GO:0030551,GO:0030552,GO:0030554,GO:0031090,GO:0031175,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0031588,GO:0031625,GO:0031690,GO:0031698,GO:0031966,GO:0031967,GO:0031975,GO:0032147,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032870,GO:0032989,GO:0032990,GO:0032991,GO:0033673,GO:0033674,GO:0033762,GO:0034199,GO:0034236,GO:0035556,GO:0036094,GO:0036477,GO:0040011,GO:0042060,GO:0042220,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042330,GO:0042383,GO:0042493,GO:0042585,GO:0042592,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043025,GO:0043073,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043197,GO:0043198,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043279,GO:0043434,GO:0043436,GO:0043549,GO:0043900,GO:0043902,GO:0043933,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044297,GO:0044309,GO:0044389,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0044853,GO:0045121,GO:0045202,GO:0045471,GO:0045475,GO:0045595,GO:0045597,GO:0045787,GO:0045859,GO:0045860,GO:0045936,GO:0045937,GO:0046677,GO:0046983,GO:0048148,GO:0048149,GO:0048468,GO:0048471,GO:0048511,GO:0048512,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048871,GO:0048878,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050817,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051018,GO:0051094,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051248,GO:0051259,GO:0051291,GO:0051338,GO:0051347,GO:0051348,GO:0051445,GO:0051446,GO:0051640,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060271,GO:0060281,GO:0060282,GO:0060284,GO:0060359,GO:0061564,GO:0061695,GO:0065003,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0070925,GO:0071310,GO:0071375,GO:0071377,GO:0071417,GO:0071495,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0071944,GO:0072347,GO:0080090,GO:0090068,GO:0097159,GO:0097305,GO:0097332,GO:0097338,GO:0097367,GO:0097447,GO:0097458,GO:0097485,GO:0097546,GO:0097711,GO:0098589,GO:0098590,GO:0098772,GO:0098794,GO:0098805,GO:0098857,GO:0120025,GO:0120031,GO:0120036,GO:0120038,GO:0120039,GO:0140056,GO:1900193,GO:1900195,GO:1901265,GO:1901363,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901987,GO:1901990,GO:1902494,GO:1902749,GO:1902911,GO:1903047,GO:1903429,GO:1903431,GO:1903538,GO:1904146,GO:1905879,GO:1905881,GO:1990234,GO:2000241,GO:2000243,GO:2000479,GO:2000480 - 0.000000006635 70.0
HFD2_k127_4873442_5 Inverse autotransporter, beta-domain K13735 - - 0.00000003948 66.0
HFD2_k127_4956914_0 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000008459 150.0
HFD2_k127_4956914_1 family 25 K01185,K07273 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.17 0.00000001526 65.0
HFD2_k127_5001067_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 5.892e-209 658.0
HFD2_k127_5001067_1 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001948 259.0
HFD2_k127_5001067_2 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.000000000000000000000000000000000000000000000000000000000000000000000000007898 261.0
HFD2_k127_5001067_3 Molybdopterin oxidoreductase K00123 - 1.17.1.9 0.000000000000000000000000003245 114.0
HFD2_k127_501532_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 308.0
HFD2_k127_501532_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002687 255.0
HFD2_k127_501532_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000147 98.0
HFD2_k127_501532_3 - - - - 0.000000000000001053 79.0
HFD2_k127_5053389_0 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 314.0
HFD2_k127_5053389_1 Oxidoreductase molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009918 274.0
HFD2_k127_5053389_2 - - - - 0.0000000000000000418 85.0
HFD2_k127_506159_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 356.0
HFD2_k127_506159_1 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000007368 92.0
HFD2_k127_5204088_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000001311 159.0
HFD2_k127_5204088_1 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000003199 134.0
HFD2_k127_5204088_2 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000004065 117.0
HFD2_k127_5204088_3 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000001906 111.0
HFD2_k127_5204088_4 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.000000000000000000000002466 104.0
HFD2_k127_527270_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 4.237e-259 825.0
HFD2_k127_527270_1 PFAM carbohydrate kinase K00854 - 2.7.1.17 8.299e-204 645.0
HFD2_k127_527270_10 Dyp-type peroxidase family K07223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 344.0
HFD2_k127_527270_11 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 342.0
HFD2_k127_527270_12 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 328.0
HFD2_k127_527270_13 ROK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 310.0
HFD2_k127_527270_14 ABC transporter substrate-binding protein K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005766 290.0
HFD2_k127_527270_15 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004058 231.0
HFD2_k127_527270_16 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172,K00177 - 1.2.7.1,1.2.7.3 0.000000000000000000000000000000000000000000005713 177.0
HFD2_k127_527270_17 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000001667 175.0
HFD2_k127_527270_18 Capsule synthesis protein K07282 - - 0.000000000000000000000000000000000002496 145.0
HFD2_k127_527270_19 Protein of unknown function (DUF1440) - - - 0.00000000000000000000000000001799 123.0
HFD2_k127_527270_2 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531,K01537,K12952 - 3.6.3.2,3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000644 611.0
HFD2_k127_527270_20 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000113 104.0
HFD2_k127_527270_21 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.0000000000000000000008546 106.0
HFD2_k127_527270_22 4Fe-4S binding domain K00176 - 1.2.7.3 0.0000000000000000002532 91.0
HFD2_k127_527270_23 COG2017 Galactose mutarotase and related enzymes K01785 - 5.1.3.3 0.0000000000000000004039 98.0
HFD2_k127_527270_24 - - - - 0.0000000000004346 80.0
HFD2_k127_527270_25 Belongs to the universal stress protein A family - - - 0.0000000005912 71.0
HFD2_k127_527270_26 - - - - 0.0001375 53.0
HFD2_k127_527270_3 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 583.0
HFD2_k127_527270_4 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 557.0
HFD2_k127_527270_5 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 544.0
HFD2_k127_527270_6 Xaa-Pro aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 509.0
HFD2_k127_527270_7 Belongs to the binding-protein-dependent transport system permease family K10544 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005207 441.0
HFD2_k127_527270_8 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 402.0
HFD2_k127_527270_9 ABC transporter K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 357.0
HFD2_k127_5276227_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000631 545.0
HFD2_k127_5276227_1 Aldehyde dehydrogenase family K00130 - 1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 494.0
HFD2_k127_5276227_10 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 347.0
HFD2_k127_5276227_11 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 322.0
HFD2_k127_5276227_12 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008538 285.0
HFD2_k127_5276227_13 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000001074 237.0
HFD2_k127_5276227_14 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000483 237.0
HFD2_k127_5276227_15 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000003562 216.0
HFD2_k127_5276227_16 Psort location CytoplasmicMembrane, score 9.49 K02006,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000001022 204.0
HFD2_k127_5276227_17 phosphorelay sensor kinase activity K16923,K18967 - 2.7.7.65 0.0000000000000000000000000000000000000001642 165.0
HFD2_k127_5276227_18 Transcriptional regulator - - - 0.0000000000000000000000000000000000000003575 154.0
HFD2_k127_5276227_19 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000001443 149.0
HFD2_k127_5276227_2 Trimethylamine methyltransferase (MTTB) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 473.0
HFD2_k127_5276227_20 Cobalt transport protein K16785 - - 0.000000000000000000000000000000000009173 147.0
HFD2_k127_5276227_21 PFAM NUDIX domain - - - 0.00000000000000000000000000000000001236 148.0
HFD2_k127_5276227_22 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.000000000000000000000009329 114.0
HFD2_k127_5276227_23 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.00000000000000000000001045 108.0
HFD2_k127_5276227_24 ThiS family K03636 GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000006285 100.0
HFD2_k127_5276227_25 Sigma-70 region 2 K03088 GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000002315 104.0
HFD2_k127_5276227_26 - - - - 0.0000001777 56.0
HFD2_k127_5276227_27 transcriptional regulator K22491 - - 0.000001761 53.0
HFD2_k127_5276227_3 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 472.0
HFD2_k127_5276227_4 PFAM UBA THIF-type NAD FAD binding protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 467.0
HFD2_k127_5276227_5 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 356.0
HFD2_k127_5276227_6 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 351.0
HFD2_k127_5276227_7 PFAM TrkA-N domain K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 343.0
HFD2_k127_5276227_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 335.0
HFD2_k127_5276227_9 Inosine-uridine preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 335.0
HFD2_k127_5313455_0 Type II/IV secretion system protein K02283 - - 1.438e-203 642.0
HFD2_k127_5313455_1 DegT/DnrJ/EryC1/StrS aminotransferase family K13010,K19430 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 515.0
HFD2_k127_5313455_10 domain protein K14645,K20276 - - 0.0000000000000000000000000000000000000000000000000006606 212.0
HFD2_k127_5313455_11 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000001586 195.0
HFD2_k127_5313455_12 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000001791 202.0
HFD2_k127_5313455_13 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000002924 193.0
HFD2_k127_5313455_14 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000008587 183.0
HFD2_k127_5313455_15 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000003409 180.0
HFD2_k127_5313455_16 Pfam:DUF2029 - - - 0.000000000000000000000000000000000000000000009618 175.0
HFD2_k127_5313455_17 Pfam:DUF2029 - - - 0.00000000000000000000000000000000000000000003025 172.0
HFD2_k127_5313455_18 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000001337 171.0
HFD2_k127_5313455_19 PFAM glycosyl transferase family 2 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000002474 170.0
HFD2_k127_5313455_2 PFAM response regulator receiver K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 346.0
HFD2_k127_5313455_20 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07777 - 2.7.13.3 0.000000000000000000000000000000000000000604 163.0
HFD2_k127_5313455_21 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000001529 139.0
HFD2_k127_5313455_22 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000001389 139.0
HFD2_k127_5313455_24 competence protein - - - 0.000000000000000000000000000208 123.0
HFD2_k127_5313455_25 Histidine kinase K07777 - 2.7.13.3 0.0000000000000000000000000508 123.0
HFD2_k127_5313455_26 Pfam:DUF2029 - - - 0.00000000000000000000000005875 124.0
HFD2_k127_5313455_27 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000005813 99.0
HFD2_k127_5313455_28 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.00000000000000002774 87.0
HFD2_k127_5313455_29 CoA-binding domain - - - 0.00000000000000639 75.0
HFD2_k127_5313455_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 302.0
HFD2_k127_5313455_31 acetyltransferase K03789 - 2.3.1.128 0.000000000004908 77.0
HFD2_k127_5313455_32 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000003359 64.0
HFD2_k127_5313455_33 methyltransferase - - - 0.0000008895 61.0
HFD2_k127_5313455_34 Flp/Fap pilin component K02651 - - 0.00001369 49.0
HFD2_k127_5313455_35 Flp/Fap pilin component K02651 - - 0.00004721 48.0
HFD2_k127_5313455_36 Helix-turn-helix - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00005385 54.0
HFD2_k127_5313455_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 303.0
HFD2_k127_5313455_5 Peptidase inhibitor I9 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008765 313.0
HFD2_k127_5313455_7 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005196 263.0
HFD2_k127_5313455_8 Type II secretion system (T2SS), protein F K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000002522 250.0
HFD2_k127_5313455_9 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000000000000000000000000000034 222.0
HFD2_k127_5341815_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005692 431.0
HFD2_k127_5341815_1 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 GO:0003674,GO:0003824,GO:0004367,GO:0006072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0046167,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000681 293.0
HFD2_k127_5341815_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001881 255.0
HFD2_k127_5341815_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002157 263.0
HFD2_k127_5341815_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000003663 224.0
HFD2_k127_5341815_5 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000003267 211.0
HFD2_k127_5341815_6 RNA pseudouridylate synthase K06178,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000004729 156.0
HFD2_k127_5341815_7 transcriptional regulator - - - 0.000000000003781 76.0
HFD2_k127_5341815_8 - - - - 0.00001077 47.0
HFD2_k127_5439244_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.354e-249 778.0
HFD2_k127_5439244_1 Lantibiotic biosynthesis dehydratase C-term K20483 - - 3.724e-246 798.0
HFD2_k127_5439244_10 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008683 439.0
HFD2_k127_5439244_11 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 436.0
HFD2_k127_5439244_12 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 420.0
HFD2_k127_5439244_13 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 393.0
HFD2_k127_5439244_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 368.0
HFD2_k127_5439244_15 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 351.0
HFD2_k127_5439244_16 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 348.0
HFD2_k127_5439244_17 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 327.0
HFD2_k127_5439244_18 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 320.0
HFD2_k127_5439244_19 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 310.0
HFD2_k127_5439244_2 FeS assembly protein SufB K09014 - - 4.34e-207 655.0
HFD2_k127_5439244_20 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000303 284.0
HFD2_k127_5439244_21 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008505 284.0
HFD2_k127_5439244_22 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000004773 255.0
HFD2_k127_5439244_23 Lanthionine synthetase C-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001386 237.0
HFD2_k127_5439244_24 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000008969 199.0
HFD2_k127_5439244_25 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000004825 191.0
HFD2_k127_5439244_26 inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000009206 205.0
HFD2_k127_5439244_27 L-asparaginase II K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000003352 195.0
HFD2_k127_5439244_28 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000008433 196.0
HFD2_k127_5439244_29 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000792 194.0
HFD2_k127_5439244_3 Dihydropyrimidinase K01464 - 3.5.2.2 8.301e-196 620.0
HFD2_k127_5439244_30 pfam nudix - - - 0.0000000000000000000000000000000000000000000006312 174.0
HFD2_k127_5439244_31 TIGRFAM FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000006884 184.0
HFD2_k127_5439244_32 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000002135 162.0
HFD2_k127_5439244_33 PFAM OsmC family protein K04063 - - 0.0000000000000000000000000000000000000007227 152.0
HFD2_k127_5439244_34 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.0000000000000000000000000000000000000008129 160.0
HFD2_k127_5439244_35 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000002491 157.0
HFD2_k127_5439244_36 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000222 148.0
HFD2_k127_5439244_37 Histidine kinase - - - 0.000000000000000000000000000000000163 151.0
HFD2_k127_5439244_39 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000002982 139.0
HFD2_k127_5439244_4 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.135e-195 627.0
HFD2_k127_5439244_40 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000003292 139.0
HFD2_k127_5439244_42 SnoaL-like domain - - - 0.0000000000000002356 85.0
HFD2_k127_5439244_43 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000000000264 85.0
HFD2_k127_5439244_44 Sigma-70 region 2 K03088 - - 0.000000000000001058 85.0
HFD2_k127_5439244_45 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000002992 87.0
HFD2_k127_5439244_46 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000017 81.0
HFD2_k127_5439244_47 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.0000000000002116 79.0
HFD2_k127_5439244_48 Protein tyrosine kinase - - - 0.00000000000892 73.0
HFD2_k127_5439244_49 AhpC/TSA antioxidant enzyme - - - 0.00000000001318 74.0
HFD2_k127_5439244_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 555.0
HFD2_k127_5439244_50 STAS domain K06378 - - 0.00000162 55.0
HFD2_k127_5439244_6 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 537.0
HFD2_k127_5439244_7 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 506.0
HFD2_k127_5439244_8 N-terminal double-glycine peptidase domain K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 514.0
HFD2_k127_5439244_9 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 462.0
HFD2_k127_5473669_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - 0.0 1305.0
HFD2_k127_5473669_1 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 395.0
HFD2_k127_5473669_10 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000000000000000000000000000000002175 221.0
HFD2_k127_5473669_11 response regulator K02479 - - 0.0000000000000000000000000000000000000000000000000000006572 202.0
HFD2_k127_5473669_12 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000001521 214.0
HFD2_k127_5473669_14 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000001912 204.0
HFD2_k127_5473669_15 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000433 200.0
HFD2_k127_5473669_16 Peptidase A4 family - - - 0.00000000000000000000000000000000000000000000001182 181.0
HFD2_k127_5473669_17 Protein of unknown function (DUF664) - - - 0.000000000000000000000000000000000000000000003097 173.0
HFD2_k127_5473669_18 Peptidase MA superfamily - - - 0.000000000000000000000000000000000002405 157.0
HFD2_k127_5473669_19 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000006199 104.0
HFD2_k127_5473669_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 358.0
HFD2_k127_5473669_20 Serine aminopeptidase, S33 - - - 0.000000000000000000002937 108.0
HFD2_k127_5473669_21 Bacterial protein of unknown function (DUF881) - - - 0.0000000000000000002293 101.0
HFD2_k127_5473669_22 Domain of unknown function (DUF4342) - - - 0.0000000000000000003403 96.0
HFD2_k127_5473669_23 Bacterial protein of unknown function (DUF951) - - - 0.000000000000001899 89.0
HFD2_k127_5473669_24 - - - - 0.00000000000001168 84.0
HFD2_k127_5473669_25 Bacterial protein of unknown function (DUF881) - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000008642 84.0
HFD2_k127_5473669_26 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.0000000007193 71.0
HFD2_k127_5473669_28 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000001017 61.0
HFD2_k127_5473669_29 - - - - 0.000003769 57.0
HFD2_k127_5473669_3 PFAM Amidohydrolase 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 357.0
HFD2_k127_5473669_31 - - - - 0.0000617 55.0
HFD2_k127_5473669_33 Belongs to the peptidase S51 family - - - 0.0006682 51.0
HFD2_k127_5473669_4 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 331.0
HFD2_k127_5473669_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007994 290.0
HFD2_k127_5473669_6 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002668 258.0
HFD2_k127_5473669_7 deoxyhypusine monooxygenase activity K01932 - - 0.00000000000000000000000000000000000000000000000000000000000000003783 253.0
HFD2_k127_5473669_8 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000001861 220.0
HFD2_k127_5473669_9 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000001646 223.0
HFD2_k127_5495388_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000001554 189.0
HFD2_k127_5495388_1 AAA domain - - - 0.0000000000000009227 89.0
HFD2_k127_5497017_0 Right handed beta helix region - - - 0.000000000000000000000000000000000000000000000001951 185.0
HFD2_k127_5497017_1 BON domain K04065 - - 0.000000000007915 72.0
HFD2_k127_554406_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005148 272.0
HFD2_k127_554406_1 Histidine biosynthesis protein K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000189 172.0
HFD2_k127_554406_2 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000001527 164.0
HFD2_k127_554406_3 TIGRFAM TrpR like protein, YerC YecD - - - 0.00000000000000000002221 94.0
HFD2_k127_5553563_0 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000002117 198.0
HFD2_k127_5553563_1 Pfam:DUF2029 - - - 0.000000000000000000000000000000000000000005625 166.0
HFD2_k127_5553563_2 acetyltransferase - - - 0.0000000000000000007552 96.0
HFD2_k127_5553563_3 Protein involved in cellulose biosynthesis - - - 0.000000000000003558 78.0
HFD2_k127_5553563_4 oligosaccharyl transferase activity - - - 0.00000000000002582 86.0
HFD2_k127_5574124_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1037.0
HFD2_k127_5574124_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002778 278.0
HFD2_k127_5574124_2 Kelch motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000418 243.0
HFD2_k127_5574124_3 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000000000000000000000000006257 153.0
HFD2_k127_5574124_5 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000005074 117.0
HFD2_k127_5692632_0 Aminotransferase class-V - - - 4.479e-245 769.0
HFD2_k127_5692632_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 339.0
HFD2_k127_5692632_2 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008195 334.0
HFD2_k127_5697233_0 Bacterial low temperature requirement A protein (LtrA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 340.0
HFD2_k127_5697233_1 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000002049 191.0
HFD2_k127_5697233_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000006116 190.0
HFD2_k127_5697233_3 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000002605 153.0
HFD2_k127_5697233_4 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000007761 144.0
HFD2_k127_5697233_5 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000006702 68.0
HFD2_k127_5733336_0 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000006025 194.0
HFD2_k127_5733336_1 AAA ATPase domain - - - 0.0001418 54.0
HFD2_k127_5902674_0 Heat shock 70 kDa protein K04043 - - 1.336e-195 620.0
HFD2_k127_5902674_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 282.0
HFD2_k127_5902674_2 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005161 256.0
HFD2_k127_5902674_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001855 258.0
HFD2_k127_5902674_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000001025 125.0
HFD2_k127_5902674_5 CAAX protease self-immunity K07052 - - 0.00004345 54.0
HFD2_k127_5942284_0 RNase_H superfamily - - - 1.777e-288 927.0
HFD2_k127_5942284_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 3.777e-197 630.0
HFD2_k127_5942284_10 Transcriptional regulatory protein, C terminal K07667 - - 0.000000000000000000000000000000000000000000000000000000000001494 217.0
HFD2_k127_5942284_11 signal transduction protein containing a membrane domain an EAL and a GGDEF domain K21023 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000002643 220.0
HFD2_k127_5942284_12 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.00000000000000000000000000000000000000000001045 180.0
HFD2_k127_5942284_13 transferase activity, transferring glycosyl groups K21369 - 2.4.1.270 0.00000000000000000000000000000000000000000006103 178.0
HFD2_k127_5942284_14 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000004977 160.0
HFD2_k127_5942284_15 O-methyltransferase - - - 0.000000000000000000000000000000000005124 147.0
HFD2_k127_5942284_16 YCII-related domain - - - 0.000000000000000000000000000000007729 134.0
HFD2_k127_5942284_17 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000001301 127.0
HFD2_k127_5942284_18 - - - - 0.0000000000000000000000006916 108.0
HFD2_k127_5942284_19 Galactose oxidase, central domain - - - 0.000000000000000000002138 107.0
HFD2_k127_5942284_2 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 610.0
HFD2_k127_5942284_20 Methicillin resistance protein - - - 0.000000000000002127 89.0
HFD2_k127_5942284_21 PFAM Transglycosylase associated protein - - - 0.00000000000002278 76.0
HFD2_k127_5942284_22 exodeoxyribonuclease I activity - - - 0.000000000002184 76.0
HFD2_k127_5942284_24 Short C-terminal domain - - - 0.0000000001746 64.0
HFD2_k127_5942284_25 YGGT family - - - 0.000000002596 66.0
HFD2_k127_5942284_26 - - - - 0.00000263 54.0
HFD2_k127_5942284_3 N-terminal domain of (some) glycogen debranching enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 565.0
HFD2_k127_5942284_4 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 477.0
HFD2_k127_5942284_5 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 379.0
HFD2_k127_5942284_6 belongs to the sigma-70 factor family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 349.0
HFD2_k127_5942284_7 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000474 286.0
HFD2_k127_5942284_8 PFAM glycosyl transferase, family 51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002528 277.0
HFD2_k127_5942284_9 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000003962 228.0
HFD2_k127_5970902_0 E1-E2 ATPase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 611.0
HFD2_k127_5970902_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000001791 90.0
HFD2_k127_6110701_0 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 478.0
HFD2_k127_6110701_1 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 410.0
HFD2_k127_6110701_2 Belongs to the long-chain O-acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 401.0
HFD2_k127_6110701_3 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 367.0
HFD2_k127_6110701_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002908 277.0
HFD2_k127_6110701_5 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001272 250.0
HFD2_k127_6145950_0 ATPases associated with a variety of cellular activities K16785,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 336.0
HFD2_k127_6145950_1 hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004905 265.0
HFD2_k127_6145950_2 TOBE domain K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006254 250.0
HFD2_k127_6145950_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000001622 241.0
HFD2_k127_6145950_4 membrane K16925 - - 0.000000000000000000000000000000000003681 146.0
HFD2_k127_6153635_0 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 490.0
HFD2_k127_6153635_1 PFAM helix-turn-helix HxlR type - - - 0.00000000000000000000000000000000000000000000000000000005654 211.0
HFD2_k127_6153635_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000001196 207.0
HFD2_k127_6153635_3 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000001305 161.0
HFD2_k127_6153635_4 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000001151 151.0
HFD2_k127_6153635_5 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000005629 100.0
HFD2_k127_6153635_6 antibiotic catabolic process K13277 - - 0.0000000000000000006584 100.0
HFD2_k127_6153635_8 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000004445 66.0
HFD2_k127_6158840_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 373.0
HFD2_k127_6158840_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003358 277.0
HFD2_k127_6158840_2 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000001678 218.0
HFD2_k127_6162424_0 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 616.0
HFD2_k127_6162424_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 584.0
HFD2_k127_6162424_2 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005163 484.0
HFD2_k127_6162424_3 PFAM peptidase S58, DmpA K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 418.0
HFD2_k127_6162424_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000038 278.0
HFD2_k127_6162424_5 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.000000000000000000000000000000000000000000000000000000000003211 222.0
HFD2_k127_6162424_6 Domain of unknown function (DUF427) - - - 0.000000000000000000000000000000000000000000000000000000002117 205.0
HFD2_k127_6162424_7 Transcriptional regulatory protein, C terminal K02483,K07667 - - 0.0000000000000000000000000000000000000000000000000000001331 205.0
HFD2_k127_6162424_8 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000006104 103.0
HFD2_k127_6181023_0 Lipase maturation factor - - - 2.605e-195 623.0
HFD2_k127_6181023_1 belongs to the aldehyde dehydrogenase family K09472 - 1.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 623.0
HFD2_k127_6181023_10 glyoxalase III activity - - - 0.00000308 57.0
HFD2_k127_6181023_11 YGGT family - - - 0.000003599 55.0
HFD2_k127_6181023_2 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 506.0
HFD2_k127_6181023_3 Major intrinsic protein - - - 0.000000000000000000000000000000000000000000000000000000000002399 217.0
HFD2_k127_6181023_4 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000003914 154.0
HFD2_k127_6181023_5 VIT family - - - 0.000000000000000000000000007481 121.0
HFD2_k127_6181023_6 PFAM DinB family protein - - - 0.000000000000000000000007347 108.0
HFD2_k127_6181023_7 - - - - 0.00000000000000001027 93.0
HFD2_k127_6181023_8 sequence-specific DNA binding K01356,K22299 - 3.4.21.88 0.000000000000009597 78.0
HFD2_k127_6181023_9 PAC2 family - - - 0.000000000000057 74.0
HFD2_k127_6280625_0 DEAD/H associated K03724 - - 0.0 1507.0
HFD2_k127_6280625_1 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 0.0 1151.0
HFD2_k127_6280625_10 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000001825 160.0
HFD2_k127_6280625_11 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000508 128.0
HFD2_k127_6280625_12 Nudix hydrolase - - - 0.00000000000000000000000004172 124.0
HFD2_k127_6280625_13 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding - - - 0.0000000000000000001514 96.0
HFD2_k127_6280625_14 Tetratrico peptide repeat - - - 0.000000006512 61.0
HFD2_k127_6280625_15 Glutamine amidotransferases class-II - - - 0.00001513 57.0
HFD2_k127_6280625_2 Protein of unknown function, DUF255 K06888 - - 3.324e-205 679.0
HFD2_k127_6280625_3 DNA polymerase LigD, polymerase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 486.0
HFD2_k127_6280625_4 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 366.0
HFD2_k127_6280625_5 histone deacetylase K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 323.0
HFD2_k127_6280625_6 Peptidase family S51 K13282 - 3.4.15.6 0.00000000000000000000000000000000000000000000000000000000000000000000000009288 258.0
HFD2_k127_6280625_7 Belongs to the FPG family K05522 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000009402 216.0
HFD2_k127_6280625_8 PFAM DoxX family protein K16937 - 1.8.5.2 0.0000000000000000000000000000000000000000000000000000003932 203.0
HFD2_k127_6280625_9 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000002853 162.0
HFD2_k127_6328148_0 Histidine kinase - - - 0.000000000000000000000000000000001474 143.0
HFD2_k127_6328148_1 - - - - 0.00000000000000000000000000000001731 135.0
HFD2_k127_6340638_0 Phospholipase D. Active site motifs. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 367.0
HFD2_k127_6340638_1 Dual-action HEIGH metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005096 251.0
HFD2_k127_6340638_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000682 156.0
HFD2_k127_6340638_3 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000002445 153.0
HFD2_k127_6340638_4 Serine hydrolase - - - 0.000000000000000000000000000007921 133.0
HFD2_k127_6340638_5 DNA-binding transcriptional activator of the SARP family - - - 0.00000000000000000000001214 112.0
HFD2_k127_6340638_6 WD40 repeat, subgroup - - - 0.000000003238 67.0
HFD2_k127_6340638_7 Tetratricopeptide repeat - - - 0.000003313 60.0
HFD2_k127_6340638_9 Bacterial Ig-like domain (group 3) - - - 0.00007287 54.0
HFD2_k127_6372487_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 513.0
HFD2_k127_6372487_1 transferase K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000007003 239.0
HFD2_k127_6372487_2 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000155 150.0
HFD2_k127_6372487_3 HAD-superfamily hydrolase, subfamily IIB - - - 0.00000000000000000000000002241 118.0
HFD2_k127_6446510_0 Nucleotidyl transferase K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 467.0
HFD2_k127_6446510_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 345.0
HFD2_k127_6446510_10 Type IV leader peptidase family K02654 - 3.4.23.43 0.00000003757 65.0
HFD2_k127_6446510_11 nUDIX hydrolase - - - 0.00001898 55.0
HFD2_k127_6446510_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003207 296.0
HFD2_k127_6446510_3 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003177 253.0
HFD2_k127_6446510_4 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000007959 230.0
HFD2_k127_6446510_5 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000007955 226.0
HFD2_k127_6446510_6 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.0000000000000000000000000000000000000000000002285 179.0
HFD2_k127_6446510_7 dienelactone hydrolase - - - 0.00000000000000000000000000000000004335 147.0
HFD2_k127_6446510_8 SMART Peptidoglycan-binding LysM - - - 0.0000000000000000000000000000000003163 148.0
HFD2_k127_6446510_9 aminopeptidase N - - - 0.000000004165 69.0
HFD2_k127_6493736_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 521.0
HFD2_k127_6493736_1 PFAM AMP-dependent synthetase and ligase K01897,K18661 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005716 516.0
HFD2_k127_6493736_10 Flavodoxin domain K00230 - 1.3.5.3 0.000000000451 67.0
HFD2_k127_6493736_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000578 54.0
HFD2_k127_6493736_2 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008944 449.0
HFD2_k127_6493736_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000004093 239.0
HFD2_k127_6493736_4 Secretory lipase - - - 0.000000000000000000000000000000000000000000000005715 193.0
HFD2_k127_6493736_5 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000006809 135.0
HFD2_k127_6493736_6 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000002142 122.0
HFD2_k127_6493736_7 Domain of unknown function (DU1801) - - - 0.0000000000000008338 83.0
HFD2_k127_6493736_8 PFAM Transglycosylase-associated protein - - - 0.000000000000001929 82.0
HFD2_k127_6493736_9 integral membrane protein - - - 0.000000000000004056 88.0
HFD2_k127_652717_0 Pirin C-terminal cupin domain K06911 - - 0.0000000000000000000000000000000000000000006698 161.0
HFD2_k127_652717_1 Glycosyl hydrolases family 18 - - - 0.000000000000000004876 98.0
HFD2_k127_6567589_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 560.0
HFD2_k127_6567589_1 PFAM UvrD REP helicase K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 466.0
HFD2_k127_6591793_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 610.0
HFD2_k127_6591793_1 RNA ligase activity K14415,K18148 GO:0003674,GO:0003824,GO:0003909,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0030145,GO:0030312,GO:0033554,GO:0034641,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 558.0
HFD2_k127_6591793_10 Metallo-beta-lactamase superfamily - - - 0.00000000000000001965 85.0
HFD2_k127_6591793_11 Archease protein family (MTH1598/TM1083) - - - 0.000000006453 66.0
HFD2_k127_6591793_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 512.0
HFD2_k127_6591793_3 ATPases associated with a variety of cellular activities K10112,K10195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 418.0
HFD2_k127_6591793_4 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000271 277.0
HFD2_k127_6591793_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000007445 226.0
HFD2_k127_6591793_6 phosphoribosyltransferase K07100 - - 0.0000000000000000000000000000000000000000000000000000001487 211.0
HFD2_k127_6591793_7 Capsule synthesis protein K07282 - - 0.0000000000000000000000000000000000000000000000000000839 194.0
HFD2_k127_6591793_8 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000002731 145.0
HFD2_k127_6591793_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000003094 108.0
HFD2_k127_6600933_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000006364 170.0
HFD2_k127_6600933_1 PFAM PKD domain containing protein - - - 0.0000000000000000001975 103.0
HFD2_k127_6600933_2 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000005449 93.0
HFD2_k127_6604195_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 6.619e-271 867.0
HFD2_k127_6604195_1 Urease alpha-subunit, N-terminal domain K01428 - 3.5.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 473.0
HFD2_k127_6604195_10 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000128 134.0
HFD2_k127_6604195_11 acetyltransferase - - - 0.00000000000000000000000009598 119.0
HFD2_k127_6604195_12 Calx-beta domain - - - 0.000000000000000004711 100.0
HFD2_k127_6604195_2 regulation of response to stimulus K01126,K21449 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005849 498.0
HFD2_k127_6604195_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 386.0
HFD2_k127_6604195_4 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009647 269.0
HFD2_k127_6604195_5 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000001404 277.0
HFD2_k127_6604195_6 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000689 178.0
HFD2_k127_6604195_7 Belongs to the urease gamma subunit family K14048 - 3.5.1.5 0.000000000000000000000000000000000000000005059 161.0
HFD2_k127_6604195_8 DUF218 domain - - - 0.000000000000000000000000000000000000000008776 162.0
HFD2_k127_6604195_9 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.0000000000000000000000000000000000000003141 160.0
HFD2_k127_6621216_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 460.0
HFD2_k127_6621216_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 404.0
HFD2_k127_6621216_10 pfam nudix K01515 - 3.6.1.13 0.00000000000000000000000000000000000000002137 165.0
HFD2_k127_6621216_11 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000000000000000000000000000000005124 160.0
HFD2_k127_6621216_12 - - - - 0.0000000000000000000000000000000000001512 147.0
HFD2_k127_6621216_13 PFAM Cysteine-rich secretory protein family - - - 0.0000000000000000000002867 107.0
HFD2_k127_6621216_14 Sigma-70, region 4 - - - 0.00000000000000002676 90.0
HFD2_k127_6621216_15 aminopeptidase N - - - 0.000000000000007923 86.0
HFD2_k127_6621216_16 Tetratricopeptide repeat - - - 0.0000000009446 68.0
HFD2_k127_6621216_2 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 392.0
HFD2_k127_6621216_3 Amidohydrolase family K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 314.0
HFD2_k127_6621216_4 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004043 255.0
HFD2_k127_6621216_5 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000009512 249.0
HFD2_k127_6621216_6 Sporulation and spore germination - - - 0.0000000000000000000000000000000000000000000000000000000006113 218.0
HFD2_k127_6621216_7 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000809 215.0
HFD2_k127_6621216_8 aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - - 0.000000000000000000000000000000000000000000000001087 189.0
HFD2_k127_6621216_9 BioY family K03523 - - 0.0000000000000000000000000000000000000000000001274 175.0
HFD2_k127_6657078_0 ATP dependent DNA ligase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 569.0
HFD2_k127_6657078_1 Domain of unknown function (DUF4331) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007657 256.0
HFD2_k127_6657078_2 CHRD domain - - - 0.0000000000000000000000000000000003316 146.0
HFD2_k127_6657078_3 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000523 107.0
HFD2_k127_6657078_4 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000006343 79.0
HFD2_k127_6657078_5 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000001229 79.0
HFD2_k127_6666979_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 589.0
HFD2_k127_6666979_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000005542 187.0
HFD2_k127_6666979_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000004216 138.0
HFD2_k127_6666979_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000002647 80.0
HFD2_k127_6750560_0 Prolyl oligopeptidase family - - - 7.252e-262 824.0
HFD2_k127_6750560_1 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 518.0
HFD2_k127_6750560_10 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000001999 234.0
HFD2_k127_6750560_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001875 224.0
HFD2_k127_6750560_12 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000000000000000006089 205.0
HFD2_k127_6750560_13 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K00982,K03564 - 1.11.1.15,2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000007271 198.0
HFD2_k127_6750560_14 ECF-type riboflavin transporter, S component K16924 - - 0.00000000000000000000000000000000000000000001914 168.0
HFD2_k127_6750560_16 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000005801 179.0
HFD2_k127_6750560_17 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000001987 161.0
HFD2_k127_6750560_18 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000000005187 153.0
HFD2_k127_6750560_19 Thiamin pyrophosphokinase, vitamin B1 binding domain K00949 - 2.7.6.2 0.000000000000000000000000000000001074 139.0
HFD2_k127_6750560_2 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008731 481.0
HFD2_k127_6750560_20 YbaK prolyl-tRNA synthetase associated region - - - 0.000000000000000000000000000000005312 137.0
HFD2_k127_6750560_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000002566 107.0
HFD2_k127_6750560_22 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000002917 93.0
HFD2_k127_6750560_23 glycolate biosynthetic process K01091,K06019,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18,3.6.1.1 0.000000000000000002851 94.0
HFD2_k127_6750560_24 Domain of unknown function (DUF4395) - - - 0.000000000001934 75.0
HFD2_k127_6750560_25 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000006991 61.0
HFD2_k127_6750560_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 447.0
HFD2_k127_6750560_4 Rhodanese Homology Domain K01011 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 397.0
HFD2_k127_6750560_5 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 372.0
HFD2_k127_6750560_6 Cytochrome b K03887 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 324.0
HFD2_k127_6750560_7 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006333 287.0
HFD2_k127_6750560_8 Helix-turn-helix type 11 domain protein K13572 - - 0.000000000000000000000000000000000000000000000000000000000000000002393 238.0
HFD2_k127_6750560_9 transmembrane transporter activity K16785,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000003631 235.0
HFD2_k127_6800408_0 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 310.0
HFD2_k127_6800408_1 COG2041 Sulfite oxidase and related enzymes - - - 0.0000000000000000000000000000000000000000000000001716 192.0
HFD2_k127_6800408_2 Pfam Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000000000000007985 127.0
HFD2_k127_6800408_3 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000001233 81.0
HFD2_k127_685145_0 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 2.37e-225 731.0
HFD2_k127_685145_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 1.769e-220 699.0
HFD2_k127_685145_10 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 332.0
HFD2_k127_685145_11 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005129 306.0
HFD2_k127_685145_12 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001297 289.0
HFD2_k127_685145_13 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005735 282.0
HFD2_k127_685145_14 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007706 287.0
HFD2_k127_685145_15 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002947 284.0
HFD2_k127_685145_16 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001056 287.0
HFD2_k127_685145_17 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000001576 271.0
HFD2_k127_685145_18 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000001083 258.0
HFD2_k127_685145_19 TIGRFAM LAO AO transport system ATPase K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000292 263.0
HFD2_k127_685145_2 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 8.023e-194 617.0
HFD2_k127_685145_20 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001789 250.0
HFD2_k127_685145_21 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000001272 245.0
HFD2_k127_685145_22 EamA-like transporter family - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000003365 243.0
HFD2_k127_685145_23 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000001611 234.0
HFD2_k127_685145_24 NhaP-type Na H and K H K03316 - - 0.0000000000000000000000000000000000000000000000000000000000003941 231.0
HFD2_k127_685145_25 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000001628 206.0
HFD2_k127_685145_26 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000008555 194.0
HFD2_k127_685145_27 UbiA prenyltransferase family K02548 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.000000000000000000000000000000000000000000000000007294 204.0
HFD2_k127_685145_28 B12- binding domain protein K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000009345 181.0
HFD2_k127_685145_29 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000001686 181.0
HFD2_k127_685145_3 Acyl- CoA dehydrogenase type 2 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 564.0
HFD2_k127_685145_30 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000001998 156.0
HFD2_k127_685145_31 Nitroreductase family - - - 0.0000000000000000000000000000000000006483 149.0
HFD2_k127_685145_32 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000007371 143.0
HFD2_k127_685145_33 Transmembrane secretion effector - - - 0.00000000000000000000000000000001133 144.0
HFD2_k127_685145_34 PFAM luciferase-like K00320 - 1.5.98.2 0.0000000000000000000000000000009422 140.0
HFD2_k127_685145_35 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000254 127.0
HFD2_k127_685145_36 belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000003504 124.0
HFD2_k127_685145_37 Copper resistance protein CopC K14166 - - 0.00000000000000000000000000003741 135.0
HFD2_k127_685145_38 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000048 128.0
HFD2_k127_685145_4 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 507.0
HFD2_k127_685145_40 lactoylglutathione lyase activity - - - 0.0000000000000000000000000004107 123.0
HFD2_k127_685145_41 Zincin-like metallopeptidase - - - 0.000000000000000000000000001303 118.0
HFD2_k127_685145_42 Probable zinc-ribbon domain - - - 0.00000000000000000000000001459 119.0
HFD2_k127_685145_43 BAAT Acyl-CoA thioester hydrolase - - - 0.00000000000000000000000006361 124.0
HFD2_k127_685145_44 CAAX protease self-immunity K07052 - - 0.0000000000000000000000001807 115.0
HFD2_k127_685145_45 FR47-like protein - - - 0.000000000000000000000005373 108.0
HFD2_k127_685145_46 MFS/sugar transport protein - - - 0.0000000000000000000003736 111.0
HFD2_k127_685145_47 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006790,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019295,GO:0019296,GO:0044237,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0050545,GO:0051186,GO:0051188,GO:0071704,GO:1901576 4.1.1.79 0.000000000000000007418 89.0
HFD2_k127_685145_48 - - - - 0.00000000000000003116 91.0
HFD2_k127_685145_49 helix_turn_helix, Arsenical Resistance Operon Repressor K22042 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000832 83.0
HFD2_k127_685145_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 447.0
HFD2_k127_685145_51 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000004459 72.0
HFD2_k127_685145_52 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000001514 76.0
HFD2_k127_685145_53 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000002955 71.0
HFD2_k127_685145_54 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.0000000005224 72.0
HFD2_k127_685145_55 Helix-turn-helix domain - - - 0.000000001519 62.0
HFD2_k127_685145_56 Cold-Shock Protein K03704 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000805 65.0
HFD2_k127_685145_58 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.00000001901 66.0
HFD2_k127_685145_59 Receptor family ligand binding region - - - 0.0000008393 62.0
HFD2_k127_685145_6 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 471.0
HFD2_k127_685145_60 Acetyltransferase (GNAT) family - - - 0.000001047 61.0
HFD2_k127_685145_61 NMT1-like family K02051 - - 0.00001053 58.0
HFD2_k127_685145_62 membrane transporter protein - - - 0.00001745 55.0
HFD2_k127_685145_63 Divergent 4Fe-4S mono-cluster K05337 - - 0.00001791 49.0
HFD2_k127_685145_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 395.0
HFD2_k127_685145_8 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 392.0
HFD2_k127_685145_9 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 338.0
HFD2_k127_7036733_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.125e-221 727.0
HFD2_k127_7036733_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.822e-212 681.0
HFD2_k127_7036733_2 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 371.0
HFD2_k127_7036733_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000006786 205.0
HFD2_k127_7036733_4 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000003128 190.0
HFD2_k127_7036733_5 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000001252 126.0
HFD2_k127_7036733_6 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000004277 136.0
HFD2_k127_7036733_7 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000003394 111.0
HFD2_k127_7036733_8 Protein of unknown function (DUF448) K07742 - - 0.000000000000003023 83.0
HFD2_k127_7056224_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 392.0
HFD2_k127_7056224_1 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 375.0
HFD2_k127_7056224_10 Anti-sigma-K factor rskA - - - 0.000002901 60.0
HFD2_k127_7056224_2 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005346 303.0
HFD2_k127_7056224_3 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000231 242.0
HFD2_k127_7056224_4 ArsC family - - - 0.0000000000000000000000000000586 120.0
HFD2_k127_7056224_5 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.00000000000000000000000000007032 126.0
HFD2_k127_7056224_6 Secreted repeat of unknown function - - - 0.0000000000000000000000002981 115.0
HFD2_k127_7056224_7 Beta-Casp domain K07576 - - 0.0000000000000001726 82.0
HFD2_k127_7056224_8 Rieske [2Fe-2S] domain - - - 0.0000000000001886 79.0
HFD2_k127_7056224_9 Iron dependent repressor, N-terminal DNA binding domain - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000437 59.0
HFD2_k127_7096368_0 decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 516.0
HFD2_k127_7096368_1 Fe-S oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 522.0
HFD2_k127_7096368_10 MoeA C-terminal region (domain IV) K00963,K03750 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1,2.7.7.9 0.0006667 44.0
HFD2_k127_7096368_2 Acyl-CoA dehydrogenase, C-terminal domain K00248,K00249 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.3.8.1,1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 414.0
HFD2_k127_7096368_3 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000376 281.0
HFD2_k127_7096368_4 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000003064 224.0
HFD2_k127_7096368_5 electron transfer flavoprotein, alpha subunit K03522 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000002259 208.0
HFD2_k127_7096368_6 Electron transfer flavoprotein domain K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - 0.000000000000000000000000000000000000000000000000002074 192.0
HFD2_k127_7096368_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000003542 188.0
HFD2_k127_7096368_8 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000004534 159.0
HFD2_k127_7096368_9 TIGRFAM molybdenum cofactor synthesis domain K03635 - 2.8.1.12 0.0000000000000000000000000000000000000003812 156.0
HFD2_k127_7128578_0 Beta-eliminating lyase K01667 - 4.1.99.1 8.888e-231 721.0
HFD2_k127_7128578_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000677 301.0
HFD2_k127_7128578_2 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002395 267.0
HFD2_k127_7128578_3 3-methyladenine DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001534 261.0
HFD2_k127_7128578_4 COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000004117 184.0
HFD2_k127_7128578_5 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000001115 131.0
HFD2_k127_7128578_6 Lytic transglycolase - - - 0.0000000000000000001007 98.0
HFD2_k127_7128578_7 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000000001686 93.0
HFD2_k127_7128578_8 Uncharacterized conserved protein (DUF2277) - - - 0.00000000001066 76.0
HFD2_k127_7147658_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 550.0
HFD2_k127_7147658_1 Permease family K06901 GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 424.0
HFD2_k127_7147658_10 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000008124 242.0
HFD2_k127_7147658_11 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000003643 200.0
HFD2_k127_7147658_12 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000008576 201.0
HFD2_k127_7147658_13 DegV family - - - 0.00000000000000000000000000000000000000000000000006644 191.0
HFD2_k127_7147658_14 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000001121 135.0
HFD2_k127_7147658_15 AzlC protein - - - 0.0000000000000000000000000001674 124.0
HFD2_k127_7147658_16 - - - - 0.0006389 51.0
HFD2_k127_7147658_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 394.0
HFD2_k127_7147658_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 332.0
HFD2_k127_7147658_4 peptidase K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 359.0
HFD2_k127_7147658_5 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 321.0
HFD2_k127_7147658_6 Mur ligase middle domain K03802 - 6.3.2.29,6.3.2.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 331.0
HFD2_k127_7147658_7 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 299.0
HFD2_k127_7147658_8 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003197 289.0
HFD2_k127_7147658_9 DRTGG domain K06873 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005233 263.0
HFD2_k127_7169617_0 cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000002224 206.0
HFD2_k127_7169617_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000001224 160.0
HFD2_k127_7169617_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000002314 124.0
HFD2_k127_7186964_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 4.254e-198 675.0
HFD2_k127_7186964_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 560.0
HFD2_k127_7186964_10 - - - - 0.00000000000000718 76.0
HFD2_k127_7186964_11 PFAM Endonuclease exonuclease phosphatase K07004 - - 0.000000000007694 80.0
HFD2_k127_7186964_12 - - - - 0.000000004318 71.0
HFD2_k127_7186964_13 impB/mucB/samB family - - - 0.00000000993 61.0
HFD2_k127_7186964_14 - - - - 0.0000008032 55.0
HFD2_k127_7186964_15 rRNA binding K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0004045 50.0
HFD2_k127_7186964_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 494.0
HFD2_k127_7186964_3 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 459.0
HFD2_k127_7186964_4 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 424.0
HFD2_k127_7186964_5 Uridine phosphorylase K00757 - 2.4.2.3 0.000000000000000000000000000000000000000000000000000000000000000001849 237.0
HFD2_k127_7186964_6 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000002419 230.0
HFD2_k127_7186964_7 DinB family - - - 0.00000000000000000000000000000000000000006712 159.0
HFD2_k127_7186964_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000002356 164.0
HFD2_k127_7186964_9 Helix-turn-helix XRE-family like proteins K07729 - - 0.000000000000004136 79.0
HFD2_k127_7193439_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1090.0
HFD2_k127_7193439_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 7.334e-265 839.0
HFD2_k127_7193439_10 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 336.0
HFD2_k127_7193439_11 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009177 327.0
HFD2_k127_7193439_12 Belongs to the binding-protein-dependent transport system permease family K01998,K11955 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 318.0
HFD2_k127_7193439_13 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 318.0
HFD2_k127_7193439_14 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002103 286.0
HFD2_k127_7193439_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000006558 274.0
HFD2_k127_7193439_16 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000001013 235.0
HFD2_k127_7193439_17 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001138 241.0
HFD2_k127_7193439_18 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002935 239.0
HFD2_k127_7193439_19 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000002499 228.0
HFD2_k127_7193439_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 475.0
HFD2_k127_7193439_20 Heat shock protein DnaJ domain protein K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000001346 228.0
HFD2_k127_7193439_21 acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000001318 219.0
HFD2_k127_7193439_22 TrkA-C domain K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000001556 202.0
HFD2_k127_7193439_23 protein-phosphocysteine-sugar phosphotransferase activity K02782,K02783 - 2.7.1.198 0.000000000000000000000000000000000000000000000000000104 189.0
HFD2_k127_7193439_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000003324 199.0
HFD2_k127_7193439_25 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity K00991,K12506 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000003574 180.0
HFD2_k127_7193439_26 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000001214 178.0
HFD2_k127_7193439_27 NYN domain - - - 0.000000000000000000000000000000000001116 158.0
HFD2_k127_7193439_28 Cytidylate kinase-like family K00760 - 2.4.2.8 0.0000000000000000000000000000000003742 143.0
HFD2_k127_7193439_29 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000004716 144.0
HFD2_k127_7193439_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 481.0
HFD2_k127_7193439_30 Putative NAD(P)-binding K03499 - - 0.000000000000000000000000000002302 134.0
HFD2_k127_7193439_31 PTS system glucitol sorbitol-specific IIA component K02781 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0051179,GO:0051234,GO:0071702 2.7.1.198 0.00000000000000000000000000003542 124.0
HFD2_k127_7193439_32 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000003132 121.0
HFD2_k127_7193439_33 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000005422 128.0
HFD2_k127_7193439_34 GTP binding - - - 0.000000000000000000000000003466 124.0
HFD2_k127_7193439_35 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000002215 113.0
HFD2_k127_7193439_36 PFAM NUDIX hydrolase - - - 0.000000000000000000000001108 111.0
HFD2_k127_7193439_37 AMP binding - - - 0.00000000000000000000006913 106.0
HFD2_k127_7193439_38 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000002443 102.0
HFD2_k127_7193439_39 PFAM MerR family regulatory protein K13640 - - 0.0000000000000000000007388 100.0
HFD2_k127_7193439_4 PFAM Transketolase central region K21417 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 429.0
HFD2_k127_7193439_40 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000000005363 100.0
HFD2_k127_7193439_41 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000002077 95.0
HFD2_k127_7193439_42 PTS HPr component phosphorylation site K11189 - - 0.000000000000000004033 86.0
HFD2_k127_7193439_43 Acyl-ACP thioesterase - - - 0.00000000001419 76.0
HFD2_k127_7193439_44 - - - - 0.000000000323 68.0
HFD2_k127_7193439_45 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000003049 67.0
HFD2_k127_7193439_47 - - - - 0.00001613 53.0
HFD2_k127_7193439_5 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 401.0
HFD2_k127_7193439_6 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 404.0
HFD2_k127_7193439_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 360.0
HFD2_k127_7193439_8 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183,K11189 - 2.7.1.202,2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 365.0
HFD2_k127_7193439_9 Dehydrogenase E1 component K21416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 350.0
HFD2_k127_7198505_0 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 591.0
HFD2_k127_7198505_1 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 348.0
HFD2_k127_7198505_2 helix_turn_helix, mercury resistance K22491 - - 0.00000000000000000000000000000000000000000000000000000002603 205.0
HFD2_k127_7198505_3 Domain of unknown function (DUF378) K09779 - - 0.00000000001248 69.0
HFD2_k127_7211066_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 599.0
HFD2_k127_7211066_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 428.0
HFD2_k127_7211066_2 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 349.0
HFD2_k127_7211066_3 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004931 256.0
HFD2_k127_7211066_4 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768,K03320 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000002288 217.0
HFD2_k127_7211066_5 Involved in manganese homeostasis. Might activate the transcription of the mntABCD operon K03709 - - 0.0000000000000000000000000000000008454 143.0
HFD2_k127_7211494_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 482.0
HFD2_k127_7211494_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 392.0
HFD2_k127_7211494_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 377.0
HFD2_k127_7211494_3 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001411 264.0
HFD2_k127_7211494_4 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000009149 248.0
HFD2_k127_7211494_5 Glycosyl hydrolases family 25 K07273 - - 0.00000000000000000000000000000000000000353 158.0
HFD2_k127_7211494_6 Pfam:Pyridox_oxidase - - - 0.000000000000000000000001344 110.0
HFD2_k127_7211494_7 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase - - - 0.000000000000000000002094 104.0
HFD2_k127_7211494_8 - - - - 0.0000000000000092 77.0
HFD2_k127_7252013_0 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 337.0
HFD2_k127_7252013_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000006549 130.0
HFD2_k127_7252013_2 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000008191 119.0
HFD2_k127_7252013_3 Helix-turn-helix domain K07729 - - 0.0000000000000000009777 87.0
HFD2_k127_7252013_5 protein phosphatase 2C domain protein - - - 0.0000001097 58.0
HFD2_k127_7252013_6 Bacterial-like globin K06886 - - 0.0000004949 53.0
HFD2_k127_7252013_7 Predicted membrane protein (DUF2178) - - - 0.0000008887 57.0
HFD2_k127_7310837_0 FAD dependent oxidoreductase central domain - - - 0.0 1130.0
HFD2_k127_7310837_1 Domain of unknown function (DUF4445) - - - 2.195e-265 843.0
HFD2_k127_7310837_10 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 399.0
HFD2_k127_7310837_11 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 397.0
HFD2_k127_7310837_12 metallophosphoesterase K07096,K07496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 381.0
HFD2_k127_7310837_13 Prokaryotic acetaldehyde dehydrogenase, dimerisation K04073 - 1.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006671 387.0
HFD2_k127_7310837_14 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 363.0
HFD2_k127_7310837_15 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 345.0
HFD2_k127_7310837_16 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008334 351.0
HFD2_k127_7310837_17 Trimethylamine methyltransferase (MTTB) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 353.0
HFD2_k127_7310837_18 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 336.0
HFD2_k127_7310837_19 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 310.0
HFD2_k127_7310837_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.736e-195 634.0
HFD2_k127_7310837_20 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001114 290.0
HFD2_k127_7310837_21 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003645 288.0
HFD2_k127_7310837_22 Electron transfer flavoprotein, beta subunit K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001985 262.0
HFD2_k127_7310837_23 PFAM binding-protein-dependent transport systems inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006403 258.0
HFD2_k127_7310837_24 hydratase K18364 - 4.2.1.132,4.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000001276 242.0
HFD2_k127_7310837_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K16049 - 1.13.11.25 0.000000000000000000000000000000000000000000000000000000000000000001446 244.0
HFD2_k127_7310837_26 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000000000000000000000000000000000000002786 233.0
HFD2_k127_7310837_27 xanthine dehydrogenase activity K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000002808 239.0
HFD2_k127_7310837_28 Transcriptional regulator IclR - - - 0.0000000000000000000000000000000000000000000000000000000000007859 229.0
HFD2_k127_7310837_29 - - - - 0.0000000000000000000000000000000000000000000000000001412 195.0
HFD2_k127_7310837_3 Asparaginase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005167 606.0
HFD2_k127_7310837_30 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K00087,K03518 - 1.17.1.4,1.2.5.3 0.000000000000000000000000000000000000000000000000003754 189.0
HFD2_k127_7310837_31 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000006291 196.0
HFD2_k127_7310837_32 Myristoyl transferase K02051 - - 0.000000000000000000000000000000000000000003176 169.0
HFD2_k127_7310837_33 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000001247 156.0
HFD2_k127_7310837_34 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000001283 132.0
HFD2_k127_7310837_35 Virulence factor - - - 0.00000000000000000001135 104.0
HFD2_k127_7310837_36 PFAM Major Facilitator Superfamily - - - 0.00000000000001204 87.0
HFD2_k127_7310837_37 FCD - - - 0.000003515 57.0
HFD2_k127_7310837_38 Putative amidase domain - - - 0.0000595 53.0
HFD2_k127_7310837_4 Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009255 595.0
HFD2_k127_7310837_5 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 490.0
HFD2_k127_7310837_6 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 456.0
HFD2_k127_7310837_7 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 430.0
HFD2_k127_7310837_8 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 417.0
HFD2_k127_7310837_9 COG1410 Methionine synthase I cobalamin-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 423.0
HFD2_k127_7343364_0 Fructose-bisphosphate aldolase class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 441.0
HFD2_k127_7343364_1 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 384.0
HFD2_k127_7343364_10 Choline/ethanolamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000001032 231.0
HFD2_k127_7343364_11 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000005055 208.0
HFD2_k127_7343364_12 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000002296 201.0
HFD2_k127_7343364_13 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000000002182 171.0
HFD2_k127_7343364_14 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000003891 160.0
HFD2_k127_7343364_15 MobA-like NTP transferase domain - - - 0.000000000000000000001079 110.0
HFD2_k127_7343364_16 helix_turn_helix, Lux Regulon - - - 0.00000000000000000007669 103.0
HFD2_k127_7343364_17 Acetyltransferase (GNAT) family - - - 0.000000000000000009566 98.0
HFD2_k127_7343364_18 DREV methyltransferase - - - 0.000000000000009438 88.0
HFD2_k127_7343364_19 carbon monoxide dehydrogenase subunit G K09386 - - 0.00000000000001258 79.0
HFD2_k127_7343364_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 387.0
HFD2_k127_7343364_20 RDD family - - - 0.000000001913 66.0
HFD2_k127_7343364_21 - - - - 0.000000002025 65.0
HFD2_k127_7343364_22 - - - - 0.00002499 52.0
HFD2_k127_7343364_3 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 316.0
HFD2_k127_7343364_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000731 305.0
HFD2_k127_7343364_5 RsgA GTPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000014 311.0
HFD2_k127_7343364_6 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 304.0
HFD2_k127_7343364_7 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002509 284.0
HFD2_k127_7343364_8 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000384 277.0
HFD2_k127_7343364_9 response regulator K07668,K07775 - - 0.0000000000000000000000000000000000000000000000000000000000000001097 230.0
HFD2_k127_7446022_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001625 297.0
HFD2_k127_7446022_1 Belongs to the peptidase M50B family - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000186 176.0
HFD2_k127_7446022_2 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.00000000000000000000000000000004118 134.0
HFD2_k127_7446022_3 CsbD-like - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000009449 98.0
HFD2_k127_7446022_4 Dodecin - - - 0.000000000000000000004757 95.0
HFD2_k127_7446022_5 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000006066 86.0
HFD2_k127_7446022_7 PFAM CBS domain K07182 - - 0.000000000000001544 90.0
HFD2_k127_7446022_8 Protein of unknown function (DUF1461) - - - 0.0000001967 63.0
HFD2_k127_7446022_9 Domain of unknown function (DUF4332) - - - 0.00007255 53.0
HFD2_k127_7459519_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 359.0
HFD2_k127_7459519_1 Protein of unknown function (DUF1385) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009797 256.0
HFD2_k127_7459519_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000003822 185.0
HFD2_k127_7459519_3 Binds the 23S rRNA K02909 - - 0.0000000000000000000003885 107.0
HFD2_k127_7459519_4 Hydrolase - - - 0.000000006656 65.0
HFD2_k127_7459519_5 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000002248 56.0
HFD2_k127_756270_0 GMC oxidoreductase K00108 - 1.1.99.1 2.219e-279 867.0
HFD2_k127_756270_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007197 563.0
HFD2_k127_756270_10 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000008931 196.0
HFD2_k127_756270_11 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000005947 187.0
HFD2_k127_756270_12 PDZ DHR GLGF domain protein K04771 - 3.4.21.107 0.0000000000000000000000000000000000003096 160.0
HFD2_k127_756270_13 belongs to the glycosyl hydrolase 13 family K01176,K01208 GO:0005575,GO:0005576 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000000000000000000000003363 148.0
HFD2_k127_756270_14 FMN_bind - - - 0.000000000000000000004646 101.0
HFD2_k127_756270_15 Belongs to the UPF0312 family - - - 0.00000000000000000003747 104.0
HFD2_k127_756270_16 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000009663 61.0
HFD2_k127_756270_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 489.0
HFD2_k127_756270_3 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 407.0
HFD2_k127_756270_4 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 330.0
HFD2_k127_756270_5 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 311.0
HFD2_k127_756270_6 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008847 297.0
HFD2_k127_756270_7 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001272 263.0
HFD2_k127_756270_8 ApbE family - - - 0.0000000000000000000000000000000000000000000000000000000000000003509 242.0
HFD2_k127_756270_9 PFAM Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000004718 225.0
HFD2_k127_757400_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000006006 230.0
HFD2_k127_757400_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000001068 78.0
HFD2_k127_757400_2 flp pilus assembly protein CpaB K02279 - - 0.000005106 59.0
HFD2_k127_7666163_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 481.0
HFD2_k127_7666163_1 HRDC domain K03657 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 0.0002061 44.0
HFD2_k127_7898741_0 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005282 271.0
HFD2_k127_7898741_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002516 276.0
HFD2_k127_7898741_2 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily K00973,K02617 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000001261 209.0
HFD2_k127_7898741_3 PFAM polysaccharide biosynthesis protein - - - 0.0000000000000000000000479 113.0
HFD2_k127_7911729_0 Sodium/hydrogen exchanger family K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009072 351.0
HFD2_k127_7911729_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000001519 217.0
HFD2_k127_7911729_2 translation initiation factor activity K06996 - - 0.00000000000000003658 96.0
HFD2_k127_7911729_3 Calcineurin-like phosphoesterase - - - 0.0000000008311 70.0
HFD2_k127_7911729_4 Ppx GppA phosphatase family protein K01524 - 3.6.1.11,3.6.1.40 0.000000001044 72.0
HFD2_k127_8014770_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 2.48e-318 996.0
HFD2_k127_8014770_1 carboxylic acid catabolic process K18334 - 4.2.1.68 9.149e-221 692.0
HFD2_k127_8014770_10 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 293.0
HFD2_k127_8014770_11 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001884 273.0
HFD2_k127_8014770_12 gntR family K05799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008407 247.0
HFD2_k127_8014770_13 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000002825 173.0
HFD2_k127_8014770_14 Repeat of unknown function (DUF346) - - - 0.00000000000000000000000000000000000000002193 158.0
HFD2_k127_8014770_15 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000002413 136.0
HFD2_k127_8014770_16 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000388 127.0
HFD2_k127_8014770_17 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000001341 112.0
HFD2_k127_8014770_18 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000005846 115.0
HFD2_k127_8014770_19 COG1555 DNA uptake protein and related DNA-binding K02237 - - 0.0000000000000000000001707 108.0
HFD2_k127_8014770_2 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005861 580.0
HFD2_k127_8014770_20 Putative stress-induced transcription regulator - - - 0.000000000000000000006001 100.0
HFD2_k127_8014770_21 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000005024 101.0
HFD2_k127_8014770_22 Phosphotransferase enzyme family - - - 0.0000000000002069 83.0
HFD2_k127_8014770_23 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00001103 58.0
HFD2_k127_8014770_25 Domain of unknown function (DU1801) - - - 0.0007966 51.0
HFD2_k127_8014770_3 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 522.0
HFD2_k127_8014770_4 Branched-chain amino acid transport system / permease component K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 428.0
HFD2_k127_8014770_5 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 397.0
HFD2_k127_8014770_6 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 367.0
HFD2_k127_8014770_7 amidohydrolase K07046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 321.0
HFD2_k127_8014770_8 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 315.0
HFD2_k127_8014770_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 309.0
HFD2_k127_8053077_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 346.0
HFD2_k127_8053077_1 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - - 0.00000003978 54.0
HFD2_k127_8053077_2 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.00001603 57.0
HFD2_k127_8058920_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 601.0
HFD2_k127_8058920_1 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 443.0
HFD2_k127_8058920_2 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 378.0
HFD2_k127_8058920_3 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000642 306.0
HFD2_k127_8058920_4 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000009529 170.0
HFD2_k127_8058920_5 ABC transporter - - - 0.00000000000000000000000000000000000000006729 173.0
HFD2_k127_8058920_6 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000268 159.0
HFD2_k127_8058920_7 Glycogen debranching enzyme - - - 0.00000009599 65.0
HFD2_k127_8092385_0 CHAD - - - 0.00000000000000000000000000000000001101 156.0
HFD2_k127_8092385_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0000000000000000000000000000000001076 138.0
HFD2_k127_8092385_2 phosphohistidine phosphatase, SixA K08296 - - 0.00000000003 73.0
HFD2_k127_8133575_0 Tetratricopeptide repeat - - - 1.408e-219 721.0
HFD2_k127_8133575_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 368.0
HFD2_k127_8133575_2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658,K09699 - 2.3.1.12,2.3.1.168,2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 325.0
HFD2_k127_8133575_3 Belongs to the globin family - - - 0.00000000000000000000000000000007512 134.0
HFD2_k127_8133575_4 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000002953 138.0
HFD2_k127_8133575_5 Globin - - - 0.00000000000000000004381 98.0
HFD2_k127_8133575_6 Molybdopterin binding aldehyde oxidase and xanthine dehydrogenase K16877 - 1.3.99.8 0.0000000002988 73.0
HFD2_k127_8133575_7 hydrolase activity, hydrolyzing O-glycosyl compounds K00690,K01187,K01206,K01215,K01226,K17624 - 2.4.1.7,3.2.1.20,3.2.1.51,3.2.1.70,3.2.1.93,3.2.1.97 0.0000000303 67.0
HFD2_k127_8200436_0 PFAM Mandelate racemase muconate lactonizing K01684 - 4.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 568.0
HFD2_k127_8200436_1 Glycosyl hydrolase family 1 K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 541.0
HFD2_k127_8200436_10 Uroporphyrinogen decarboxylase (URO-D) K01599,K14080 - 2.1.1.246,4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 369.0
HFD2_k127_8200436_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 385.0
HFD2_k127_8200436_12 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 366.0
HFD2_k127_8200436_13 Aldo keto reductase K00064 - 1.1.1.122 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 349.0
HFD2_k127_8200436_14 mandelate racemase muconate lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 343.0
HFD2_k127_8200436_15 helix_turn _helix lactose operon repressor K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 337.0
HFD2_k127_8200436_16 gluconolactonase activity K01053,K02352 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 330.0
HFD2_k127_8200436_17 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 324.0
HFD2_k127_8200436_18 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 312.0
HFD2_k127_8200436_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 303.0
HFD2_k127_8200436_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 486.0
HFD2_k127_8200436_20 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 299.0
HFD2_k127_8200436_21 Belongs to the binding-protein-dependent transport system permease family K10440,K17206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006824 296.0
HFD2_k127_8200436_22 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009704 293.0
HFD2_k127_8200436_23 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003009 285.0
HFD2_k127_8200436_24 Phosphotriesterase related K07048 GO:0008150,GO:0009888,GO:0009987,GO:0030154,GO:0030855,GO:0032502,GO:0048856,GO:0048869,GO:0060429 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007227 286.0
HFD2_k127_8200436_25 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003304 277.0
HFD2_k127_8200436_26 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008064 286.0
HFD2_k127_8200436_27 transcriptional regulator K02444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000184 266.0
HFD2_k127_8200436_28 MlrC C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000494 268.0
HFD2_k127_8200436_29 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004201 251.0
HFD2_k127_8200436_3 mandelate racemase muconate lactonizing K18983 - 5.5.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005611 457.0
HFD2_k127_8200436_30 dihydrodipicolinate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000006084 246.0
HFD2_k127_8200436_31 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001012 244.0
HFD2_k127_8200436_32 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000006566 245.0
HFD2_k127_8200436_33 ABC transporter K02056,K10554 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000001127 233.0
HFD2_k127_8200436_34 (ABC) transporter K10554 - - 0.000000000000000000000000000000000000000000000000000000000000002838 231.0
HFD2_k127_8200436_35 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000003224 223.0
HFD2_k127_8200436_36 cobalamin binding - - - 0.000000000000000000000000000000000000000000000000000000000009671 217.0
HFD2_k127_8200436_37 methionine synthase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000001737 220.0
HFD2_k127_8200436_38 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.00000000000000000000000000000000000000000000000000000001325 212.0
HFD2_k127_8200436_39 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000001761 215.0
HFD2_k127_8200436_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983 - 5.5.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 448.0
HFD2_k127_8200436_40 Belongs to the binding-protein-dependent transport system permease family K10440,K17206 - - 0.00000000000000000000000000000000000000000000000000003747 202.0
HFD2_k127_8200436_41 Branched-chain amino acid transport system / permease component K10440,K10560 - - 0.00000000000000000000000000000000000000000000000000009977 206.0
HFD2_k127_8200436_42 KR domain - - - 0.0000000000000000000000000000000000000000000000000002183 199.0
HFD2_k127_8200436_43 Binding-protein-dependent transport system inner membrane component K17236 - - 0.0000000000000000000000000000000000000000000000000009125 203.0
HFD2_k127_8200436_44 carbohydrate transport K17234 - - 0.000000000000000000000000000000000000000000000000004404 205.0
HFD2_k127_8200436_45 Binding-protein-dependent transport system inner membrane component K02025,K10189 - - 0.000000000000000000000000000000000000000000000000009161 191.0
HFD2_k127_8200436_46 Enoyl-(Acyl carrier protein) reductase K00059,K00065 - 1.1.1.100,1.1.1.127 0.00000000000000000000000000000000000000000000000001279 196.0
HFD2_k127_8200436_47 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000006436 191.0
HFD2_k127_8200436_48 Periplasmic binding protein domain K10439 - - 0.0000000000000000000000000000000000000000000000001971 190.0
HFD2_k127_8200436_49 alcohol dehydrogenase K00153 - 1.1.1.306 0.0000000000000000000000000000000000000000000000621 182.0
HFD2_k127_8200436_5 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 435.0
HFD2_k127_8200436_50 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000001936 180.0
HFD2_k127_8200436_51 KR domain - - - 0.0000000000000000000000000000000000000000000002785 176.0
HFD2_k127_8200436_52 COG0395 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000003609 181.0
HFD2_k127_8200436_53 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000001783 176.0
HFD2_k127_8200436_54 Periplasmic binding protein domain K02529 - - 0.00000000000000000000000000000000000000000007018 176.0
HFD2_k127_8200436_55 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000002097 166.0
HFD2_k127_8200436_56 Enoyl-(Acyl carrier protein) reductase K00046 - 1.1.1.69 0.0000000000000000000000000000000000000002031 160.0
HFD2_k127_8200436_57 PFAM short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000194 154.0
HFD2_k127_8200436_58 PFAM short-chain dehydrogenase reductase SDR K00068,K03366,K08261 - 1.1.1.140,1.1.1.304,1.1.1.76,1.1.99.21 0.0000000000000000000000000000000000004117 150.0
HFD2_k127_8200436_59 Protein of unknown function (DUF1638) - - - 0.000000000000000000000000000000000001359 151.0
HFD2_k127_8200436_6 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 424.0
HFD2_k127_8200436_60 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000003466 142.0
HFD2_k127_8200436_61 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000001816 138.0
HFD2_k127_8200436_62 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000008976 140.0
HFD2_k127_8200436_63 Amidohydrolase - - - 0.000000000000000000000000000007752 120.0
HFD2_k127_8200436_64 Lipocalin-like domain - - - 0.000000000000000000000000001329 126.0
HFD2_k127_8200436_65 L-rhamnose mutarotase K03534 - 5.1.3.32 0.00000000000000000000000002628 117.0
HFD2_k127_8200436_66 Endoribonuclease L-PSP - - - 0.00000000000000000000000003211 112.0
HFD2_k127_8200436_67 PFAM Neutral alkaline nonlysosomal ceramidase - - - 0.00000000000000000000003775 115.0
HFD2_k127_8200436_68 Converts the aldose L-fucose into the corresponding ketose L-fuculose K01804 - 5.3.1.4 0.0000000000000000000001208 112.0
HFD2_k127_8200436_69 Periplasmic binding protein domain K10439 - - 0.000000000000000000001244 108.0
HFD2_k127_8200436_7 transferase K07749,K18702 - 2.8.3.16,2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 419.0
HFD2_k127_8200436_70 Periplasmic binding protein domain K02058 - - 0.00000000000000000003341 106.0
HFD2_k127_8200436_71 Involved in the anomeric conversion of L-rhamnose K03534 - 5.1.3.32 0.000000000000000004119 87.0
HFD2_k127_8200436_72 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000002456 81.0
HFD2_k127_8200436_73 L-rhamnose mutarotase K03534 - 5.1.3.32 0.00000001209 64.0
HFD2_k127_8200436_74 Periplasmic binding protein domain K10439,K10552 - - 0.000008651 58.0
HFD2_k127_8200436_8 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 429.0
HFD2_k127_8200436_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 394.0
HFD2_k127_8471117_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 346.0
HFD2_k127_8471117_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000004653 252.0
HFD2_k127_8512466_0 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 479.0
HFD2_k127_8512466_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 420.0
HFD2_k127_8512466_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 310.0
HFD2_k127_8512466_3 Glutamine amidotransferase of anthranilate synthase K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000004323 220.0
HFD2_k127_8512466_4 YjbR - - - 0.0000001844 63.0
HFD2_k127_8598922_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 2.778e-221 697.0
HFD2_k127_8598922_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000004236 246.0
HFD2_k127_8598922_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000005382 242.0
HFD2_k127_8606264_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.789e-252 798.0
HFD2_k127_8606264_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 7.665e-249 779.0
HFD2_k127_8606264_10 Major facilitator Superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000006877 209.0
HFD2_k127_8606264_11 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000005399 175.0
HFD2_k127_8606264_12 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000002843 179.0
HFD2_k127_8606264_13 galactose-6-phosphate isomerase activity K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000004765 175.0
HFD2_k127_8606264_14 Rieske-like [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000003431 168.0
HFD2_k127_8606264_15 Belongs to the carbohydrate kinase PfkB family - - - 0.000000000000000000000000000000000000002556 159.0
HFD2_k127_8606264_16 PNKP adenylyltransferase domain, ligase domain K01090 - 3.1.3.16 0.0000000000000000000000000000000007771 140.0
HFD2_k127_8606264_17 Putative Phosphatase - - - 0.000000000000000000000000000001143 132.0
HFD2_k127_8606264_18 TIGRFAM 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000001256 124.0
HFD2_k127_8606264_19 Glucose-6-phosphate dehydrogenase subunit - - - 0.00000000000000000000001701 118.0
HFD2_k127_8606264_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 601.0
HFD2_k127_8606264_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000001322 93.0
HFD2_k127_8606264_21 Cyclic-di-AMP receptor - - - 0.00000000004211 70.0
HFD2_k127_8606264_22 - - - - 0.0000005346 59.0
HFD2_k127_8606264_24 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.0001666 55.0
HFD2_k127_8606264_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 579.0
HFD2_k127_8606264_4 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 442.0
HFD2_k127_8606264_5 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 383.0
HFD2_k127_8606264_6 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 352.0
HFD2_k127_8606264_7 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 301.0
HFD2_k127_8606264_8 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009556 287.0
HFD2_k127_8606264_9 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000002738 235.0
HFD2_k127_881048_0 xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 622.0
HFD2_k127_881048_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 422.0
HFD2_k127_881048_10 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000704 231.0
HFD2_k127_881048_11 PFAM Pyridoxal-dependent decarboxylase conserved domain K01580,K01593,K13745 - 4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86 0.0000000000000000000000000000000000000000000000000000000000007381 231.0
HFD2_k127_881048_12 Methionine synthase B12-binding module cap domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001376 214.0
HFD2_k127_881048_13 membrane - - - 0.0000000000000000000000000000000000000000000000000000001301 203.0
HFD2_k127_881048_14 [2Fe-2S] binding domain K03518,K19819 - 1.2.5.3,1.5.99.4 0.000000000000000000000000000000000000000000000000007156 191.0
HFD2_k127_881048_15 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000002724 181.0
HFD2_k127_881048_16 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000003932 172.0
HFD2_k127_881048_17 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000006182 175.0
HFD2_k127_881048_18 PFAM major facilitator superfamily MFS_1 K03449 - - 0.000000000000000000000000000000000000001333 164.0
HFD2_k127_881048_19 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000001223 123.0
HFD2_k127_881048_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 399.0
HFD2_k127_881048_20 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000002264 114.0
HFD2_k127_881048_21 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000539 94.0
HFD2_k127_881048_22 Rdx family K07401 - - 0.00000000006138 68.0
HFD2_k127_881048_23 - - - - 0.00008243 56.0
HFD2_k127_881048_3 PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 353.0
HFD2_k127_881048_4 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 343.0
HFD2_k127_881048_5 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 322.0
HFD2_k127_881048_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 304.0
HFD2_k127_881048_7 Homocysteine S-methyltransferase K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000305 281.0
HFD2_k127_881048_8 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000002945 269.0
HFD2_k127_881048_9 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000003494 258.0
HFD2_k127_908862_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 419.0
HFD2_k127_908862_1 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 383.0
HFD2_k127_908862_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 357.0
HFD2_k127_908862_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009943 310.0
HFD2_k127_908862_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000001024 219.0
HFD2_k127_908862_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000009501 167.0
HFD2_k127_908862_6 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.0000000000000000004187 88.0
HFD2_k127_908862_7 PFAM Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000003459 68.0
HFD2_k127_948890_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 362.0
HFD2_k127_948890_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002863 290.0
HFD2_k127_948890_10 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000001948 154.0
HFD2_k127_948890_12 PFAM membrane-flanked domain - - - 0.000000000000000000003675 107.0
HFD2_k127_948890_13 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000004508 104.0
HFD2_k127_948890_14 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000007984 83.0
HFD2_k127_948890_15 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000002948 85.0
HFD2_k127_948890_16 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000001987 65.0
HFD2_k127_948890_17 mRNA catabolic process - - - 0.000000003249 68.0
HFD2_k127_948890_18 cell division - - - 0.0000001288 54.0
HFD2_k127_948890_19 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00009764 46.0
HFD2_k127_948890_2 Belongs to the 'phage' integrase family. XerC subfamily K04763 GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003073 268.0
HFD2_k127_948890_3 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000001913 240.0
HFD2_k127_948890_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000004144 231.0
HFD2_k127_948890_5 Creatinase/Prolidase N-terminal domain K01262,K01271,K08326 GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000001371 226.0
HFD2_k127_948890_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000001577 185.0
HFD2_k127_948890_7 - - - - 0.0000000000000000000000000000000000000000001289 174.0
HFD2_k127_948890_8 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000001137 174.0
HFD2_k127_948890_9 Peptidase M50 - - - 0.00000000000000000000000000000000000000002201 161.0
HFD2_k127_974052_0 Dienelactone hydrolase family - - - 1.157e-194 640.0
HFD2_k127_974052_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 550.0
HFD2_k127_974052_10 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000003157 177.0
HFD2_k127_974052_11 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000922 137.0
HFD2_k127_974052_12 FR47-like protein - - - 0.00000000000000000000001803 117.0
HFD2_k127_974052_2 adenosylhomocysteinase activity K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 546.0
HFD2_k127_974052_3 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007651 417.0
HFD2_k127_974052_4 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 415.0
HFD2_k127_974052_5 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 365.0
HFD2_k127_974052_6 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 355.0
HFD2_k127_974052_7 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 317.0
HFD2_k127_974052_8 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000003236 227.0
HFD2_k127_974052_9 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000002602 189.0
HFD2_k127_98761_0 Lysine-2,3-aminomutase K01843 - 5.4.3.2 1.189e-218 691.0
HFD2_k127_98761_1 PFAM MMPL domain protein K06994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 595.0
HFD2_k127_98761_10 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002745 256.0
HFD2_k127_98761_11 L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000002165 231.0
HFD2_k127_98761_12 Histidine kinase K07642 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000005758 222.0
HFD2_k127_98761_13 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000417 192.0
HFD2_k127_98761_14 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000006935 173.0
HFD2_k127_98761_15 Inhibitor of apoptosis-promoting Bax1 K06890,K19416 - - 0.00000000000000000000000000000000000000000468 168.0
HFD2_k127_98761_16 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000005885 151.0
HFD2_k127_98761_17 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000006939 141.0
HFD2_k127_98761_18 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000001069 133.0
HFD2_k127_98761_19 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.000000000000000000000000000004653 122.0
HFD2_k127_98761_2 Multicopper oxidase K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009058 492.0
HFD2_k127_98761_20 DSBA-like thioredoxin domain - - - 0.000000000000000000000001704 113.0
HFD2_k127_98761_21 ABC-2 family transporter protein K01992 - - 0.0000000000000000000008168 108.0
HFD2_k127_98761_22 PFAM Vitamin K epoxide reductase - - - 0.0000000000001242 78.0
HFD2_k127_98761_23 Pfam:DUF59 - - - 0.0000000000001293 76.0
HFD2_k127_98761_24 transcriptional regulator, Rrf2 family K13643 - - 0.000000000003296 73.0
HFD2_k127_98761_25 Negative regulatory protein YxlE - - - 0.000000000008134 70.0
HFD2_k127_98761_26 Protein of unknown function (DUF433) - - - 0.0000004201 59.0
HFD2_k127_98761_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 454.0
HFD2_k127_98761_4 COG0475 Kef-type K transport systems, membrane components K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009515 432.0
HFD2_k127_98761_5 COG0147 Anthranilate para-aminobenzoate synthases component I K01665 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 355.0
HFD2_k127_98761_6 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 364.0
HFD2_k127_98761_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001631 280.0
HFD2_k127_98761_8 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001236 263.0
HFD2_k127_98761_9 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004843 267.0