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Overview

ID MAG01639
Name HFD2_bin.27
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family SG8-39
Genus JAABQT01
Species
Assembly information
Completeness (%) 87.44
Contamination (%) 3.17
GC content (%) 69.0
N50 (bp) 17,323
Genome size (bp) 2,941,581

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3035

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1020779_0 AMP-binding enzyme K12508 - 6.2.1.34 3.202e-205 654.0
HFD2_k127_1020779_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K00481 - 1.14.13.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 543.0
HFD2_k127_1020779_10 Endoribonuclease L-PSP - - - 0.00000000000000000000000006007 119.0
HFD2_k127_1020779_11 (Lipo)protein - - - 0.00000000000000002174 88.0
HFD2_k127_1020779_12 (Lipo)protein - - - 0.00000000000001138 82.0
HFD2_k127_1020779_13 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000001368 58.0
HFD2_k127_1020779_2 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 535.0
HFD2_k127_1020779_3 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 415.0
HFD2_k127_1020779_4 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 380.0
HFD2_k127_1020779_5 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000000000000000000000000000000004339 212.0
HFD2_k127_1020779_6 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000000000002858 203.0
HFD2_k127_1020779_7 protocatechuate 3,4-dioxygenase activity K03381 - 1.13.11.1 0.0000000000000000000000000000000000000000000000000000002608 201.0
HFD2_k127_1020779_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000002316 120.0
HFD2_k127_1020779_9 Thioesterase superfamily K01075 - 3.1.2.23 0.00000000000000000000000002733 126.0
HFD2_k127_1136542_0 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.00000000000000000000000000000000000000000000000007458 188.0
HFD2_k127_1136542_1 Putative esterase - - - 0.0000000000000000000000000000000000000008819 153.0
HFD2_k127_1136542_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000301 116.0
HFD2_k127_1203167_0 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 576.0
HFD2_k127_1203167_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 483.0
HFD2_k127_1203167_2 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 430.0
HFD2_k127_1203167_3 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000031 168.0
HFD2_k127_1203167_4 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.00000000000000000000000000000000000005027 147.0
HFD2_k127_1203167_5 Succinate dehydrogenase hydrophobic membrane anchor protein K00242 - - 0.000000000000000000000000000000000009122 147.0
HFD2_k127_1219014_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 5.496e-316 974.0
HFD2_k127_1276869_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1313.0
HFD2_k127_1276869_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 396.0
HFD2_k127_1276869_10 Thioesterase - - - 0.000000000000000000000000003088 127.0
HFD2_k127_1276869_11 Protein of unknown function (DUF1090) - - - 0.0000000001173 70.0
HFD2_k127_1276869_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 361.0
HFD2_k127_1276869_3 PFAM NnrS family protein K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 349.0
HFD2_k127_1276869_4 Protein of unknown function (DUF2914) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009996 282.0
HFD2_k127_1276869_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006398 271.0
HFD2_k127_1276869_6 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006849 244.0
HFD2_k127_1276869_7 Cupin 2, conserved barrel - - - 0.000000000000000000000000000000000000000000002181 167.0
HFD2_k127_1276869_8 Universal stress protein - - - 0.0000000000000000000000000000000001716 138.0
HFD2_k127_1276869_9 universal stress protein - - - 0.00000000000000000000000000001374 128.0
HFD2_k127_136274_0 Oxidoreductase domain protein - - - 5.745e-205 646.0
HFD2_k127_136274_1 succinate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 584.0
HFD2_k127_136274_10 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 329.0
HFD2_k127_136274_11 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 288.0
HFD2_k127_136274_12 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009576 288.0
HFD2_k127_136274_13 COG0235, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002274 293.0
HFD2_k127_136274_14 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001268 269.0
HFD2_k127_136274_15 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001222 245.0
HFD2_k127_136274_16 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002564 248.0
HFD2_k127_136274_17 4-carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000002307 184.0
HFD2_k127_136274_18 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.000000000000000000000000000000000000000004972 173.0
HFD2_k127_136274_2 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 566.0
HFD2_k127_136274_20 peptidyl-tyrosine sulfation - - - 0.00000000002721 71.0
HFD2_k127_136274_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 561.0
HFD2_k127_136274_4 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 550.0
HFD2_k127_136274_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 536.0
HFD2_k127_136274_6 Aminotransferase K09758 - 4.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 526.0
HFD2_k127_136274_7 Zinc-binding dehydrogenase K00001,K19745 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 504.0
HFD2_k127_136274_8 Phospholipase D Transphosphatidylase K06132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 484.0
HFD2_k127_136274_9 Sodium/calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 367.0
HFD2_k127_138923_0 Ammonium Transporter K03320 - - 1.726e-219 692.0
HFD2_k127_138923_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000981 614.0
HFD2_k127_138923_10 Thioesterase superfamily - - - 0.000000000000000000000001651 109.0
HFD2_k127_138923_11 Membrane fusogenic activity K09806 - - 0.00000000000000004201 83.0
HFD2_k127_138923_2 protocatechuate 3,4-dioxygenase, beta subunit' K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 363.0
HFD2_k127_138923_3 3-carboxy-cis,cis-muconate cycloisomerase K01857 - 5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 358.0
HFD2_k127_138923_4 fumarylacetoacetate (FAA) hydrolase K16165 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009167 283.0
HFD2_k127_138923_5 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000002609 264.0
HFD2_k127_138923_6 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002416 250.0
HFD2_k127_138923_7 protocatechuate 3,4-dioxygenase, alpha K00448 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000000004421 241.0
HFD2_k127_138923_8 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000558 254.0
HFD2_k127_138923_9 Belongs to the P(II) protein family K04752 - - 0.000000000000000000000000000000000000000000000000000000001322 203.0
HFD2_k127_1408649_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 5.208e-312 972.0
HFD2_k127_1408649_1 MgsA AAA+ ATPase C terminal K07478 - - 3.564e-194 619.0
HFD2_k127_1408649_10 Transcriptional regulator crp fnr family K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002852 252.0
HFD2_k127_1408649_11 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000000000000000000000000003785 212.0
HFD2_k127_1408649_12 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000001659 201.0
HFD2_k127_1408649_13 Smr protein MutS2 - - - 0.000000000000000000000000000000000000000000000000004987 186.0
HFD2_k127_1408649_14 FecR protein - - - 0.00000000000000000000000000000000000000000000001309 179.0
HFD2_k127_1408649_15 carbon starvation protein CstA K06200 - - 0.000000000000004324 80.0
HFD2_k127_1408649_16 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000002361 63.0
HFD2_k127_1408649_17 receptor - - - 0.00002741 48.0
HFD2_k127_1408649_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 589.0
HFD2_k127_1408649_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 575.0
HFD2_k127_1408649_4 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007635 526.0
HFD2_k127_1408649_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 499.0
HFD2_k127_1408649_6 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 440.0
HFD2_k127_1408649_7 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 378.0
HFD2_k127_1408649_8 carbon starvation protein CstA K06200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 332.0
HFD2_k127_1408649_9 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 305.0
HFD2_k127_1428101_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 6.242e-263 829.0
HFD2_k127_1428101_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 522.0
HFD2_k127_1428101_2 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 482.0
HFD2_k127_1428101_3 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 357.0
HFD2_k127_1428101_4 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 354.0
HFD2_k127_1428101_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000634 82.0
HFD2_k127_1459752_0 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 621.0
HFD2_k127_1459752_1 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 546.0
HFD2_k127_1459752_2 thymidine phosphorylase K00758 - 2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 344.0
HFD2_k127_1459752_3 cytochrome c oxidase, cbb3-type, subunit II K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 329.0
HFD2_k127_1459752_4 FixH K09926 - - 0.0000000000000000000000000000000000001295 145.0
HFD2_k127_1459752_5 - - - - 0.000000000000000000000002504 111.0
HFD2_k127_1459752_6 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0000000002805 62.0
HFD2_k127_1504700_0 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 574.0
HFD2_k127_1504700_1 Tartrate dehydrogenase K07246 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 497.0
HFD2_k127_1504700_2 Permeases of the drug metabolite transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 327.0
HFD2_k127_1504700_3 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000000000000000000000000353 206.0
HFD2_k127_1504700_4 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000008088 180.0
HFD2_k127_1504700_5 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000003211 169.0
HFD2_k127_1504700_6 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000007016 81.0
HFD2_k127_15165_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 584.0
HFD2_k127_15165_1 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 332.0
HFD2_k127_15165_2 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000001029 218.0
HFD2_k127_15165_3 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000002481 155.0
HFD2_k127_1516863_0 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 9.23e-198 626.0
HFD2_k127_1516863_1 Nitronate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 429.0
HFD2_k127_1516863_2 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 406.0
HFD2_k127_1516863_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 358.0
HFD2_k127_1516863_4 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 334.0
HFD2_k127_1516863_5 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000001242 232.0
HFD2_k127_157117_0 COG4618 ABC-type protease lipase transport system, ATPase and permease components K16299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 496.0
HFD2_k127_157117_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000003263 129.0
HFD2_k127_157117_2 type I secretion membrane fusion K02022,K12537 - - 0.0000000000000000000000000001502 120.0
HFD2_k127_1578232_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1697.0
HFD2_k127_1578232_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1388.0
HFD2_k127_1578232_10 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006306 372.0
HFD2_k127_1578232_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 349.0
HFD2_k127_1578232_12 Oxidative deamination of D-amino acids - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 354.0
HFD2_k127_1578232_13 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 319.0
HFD2_k127_1578232_14 Protein of unknown function (DUF1571) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 317.0
HFD2_k127_1578232_15 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 294.0
HFD2_k127_1578232_16 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007748 281.0
HFD2_k127_1578232_17 TIGRFAM TRAP transporter solute receptor, TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000012 279.0
HFD2_k127_1578232_18 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000006304 267.0
HFD2_k127_1578232_19 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000001517 240.0
HFD2_k127_1578232_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 1.751e-240 749.0
HFD2_k127_1578232_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000001188 219.0
HFD2_k127_1578232_21 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000009901 229.0
HFD2_k127_1578232_22 SpoIIAA-like - - - 0.000000000000000000000000000000000000000000000001231 177.0
HFD2_k127_1578232_23 transcriptional regulator K07734 - - 0.000000000000000000000000000000000000000000000001921 190.0
HFD2_k127_1578232_24 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000000000000000000000000756 177.0
HFD2_k127_1578232_25 oxidation-reduction process K09022 - 3.5.99.10 0.00000000000000000000000000000000000000001895 155.0
HFD2_k127_1578232_26 membrane K15977 - - 0.0000000000000000000000000000000000000001889 153.0
HFD2_k127_1578232_27 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000001287 145.0
HFD2_k127_1578232_28 Protein of unknown function (DUF2799) - - - 0.0000000000000000000000000000929 123.0
HFD2_k127_1578232_29 translation initiation factor activity - - - 0.0000000000000000000000000007367 132.0
HFD2_k127_1578232_3 Transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 612.0
HFD2_k127_1578232_30 PFAM GYD family protein - - - 0.000000000000000000000000005753 116.0
HFD2_k127_1578232_31 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000001748 112.0
HFD2_k127_1578232_32 Protein of unknown function (DUF1161) - - - 0.0000000000000001567 81.0
HFD2_k127_1578232_33 TonB-dependent receptor - - - 0.0008446 50.0
HFD2_k127_1578232_4 FAD binding domain K20940 - 1.14.13.218 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 516.0
HFD2_k127_1578232_5 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 480.0
HFD2_k127_1578232_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K10621 - 1.13.11.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 409.0
HFD2_k127_1578232_7 Histidine kinase K07638 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 407.0
HFD2_k127_1578232_8 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007556 387.0
HFD2_k127_1578232_9 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 361.0
HFD2_k127_1647302_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 3.167e-231 730.0
HFD2_k127_1647302_1 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 457.0
HFD2_k127_1647302_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 417.0
HFD2_k127_1647302_3 aminopeptidase K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 342.0
HFD2_k127_1647302_4 FAD binding domain K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008699 260.0
HFD2_k127_1647302_5 Bacterial regulatory protein, Fis family K03557 - - 0.00000000000000000000007819 102.0
HFD2_k127_1696347_0 Fumarate reductase flavoprotein C-term - - - 1.072e-254 797.0
HFD2_k127_1696347_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 9.831e-235 729.0
HFD2_k127_1696347_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000003044 204.0
HFD2_k127_1696347_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000234 155.0
HFD2_k127_1696347_12 Preprotein translocase subunit SecG K03075 - - 0.00000000000000000000000000000002505 130.0
HFD2_k127_1696347_13 Fumarate reductase subunit C - - - 0.00000000000000000000000000001237 131.0
HFD2_k127_1696347_14 Fumarate reductase subunit D - - - 0.00000000000001712 82.0
HFD2_k127_1696347_15 Dehydrogenase E1 component K21416 - - 0.000000000001206 71.0
HFD2_k127_1696347_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 502.0
HFD2_k127_1696347_3 C4-dicarboxylate transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 501.0
HFD2_k127_1696347_4 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 442.0
HFD2_k127_1696347_5 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 341.0
HFD2_k127_1696347_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 315.0
HFD2_k127_1696347_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 304.0
HFD2_k127_1696347_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000004966 270.0
HFD2_k127_1696347_9 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000007247 246.0
HFD2_k127_1717441_0 Protein of unknown function - - - 2.145e-276 894.0
HFD2_k127_1717441_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.177e-273 866.0
HFD2_k127_1717441_10 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000324 281.0
HFD2_k127_1717441_11 Protein of unknown function (DUF2889) - - - 0.00000000000000000000000000000000000000000000000000000000002595 215.0
HFD2_k127_1717441_12 Protein of unknown function (DUF3047) - - - 0.00000000000000000000000000000000000000000000000000000164 202.0
HFD2_k127_1717441_13 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000001216 166.0
HFD2_k127_1717441_14 Transcriptional regulator - - - 0.00000000000000000000001579 103.0
HFD2_k127_1717441_15 Zinc-finger domain - - - 0.0000000000000000001096 102.0
HFD2_k127_1717441_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 4.69e-212 669.0
HFD2_k127_1717441_3 FAD dependent oxidoreductase K00111 - 1.1.5.3 1.247e-202 644.0
HFD2_k127_1717441_4 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 4.035e-202 669.0
HFD2_k127_1717441_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 523.0
HFD2_k127_1717441_6 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 482.0
HFD2_k127_1717441_7 heptosyltransferase II K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 362.0
HFD2_k127_1717441_8 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 323.0
HFD2_k127_1717441_9 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006734 279.0
HFD2_k127_1749076_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1470.0
HFD2_k127_1749076_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007714 397.0
HFD2_k127_1749076_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 343.0
HFD2_k127_1749076_3 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 299.0
HFD2_k127_1749076_4 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000007928 223.0
HFD2_k127_1749076_5 Putative regulatory protein - - - 0.0000000000000000000000001375 112.0
HFD2_k127_1749076_6 Bacterial regulatory proteins, tetR family K16137 - - 0.000000000000000000001109 98.0
HFD2_k127_1765956_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 391.0
HFD2_k127_1765956_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000001497 191.0
HFD2_k127_1765956_2 Belongs to the phosphoglycerate mutase family K15634 - 5.4.2.12 0.0000000000000000000004327 110.0
HFD2_k127_1799333_0 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 525.0
HFD2_k127_1799333_1 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 501.0
HFD2_k127_1799333_2 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 426.0
HFD2_k127_1799333_3 3-5 exonuclease K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 364.0
HFD2_k127_1799333_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 302.0
HFD2_k127_1799333_5 TIGRFAM rfaE bifunctional protein K03272,K21344 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000007784 265.0
HFD2_k127_1799333_6 PFAM Transglycosylase-associated protein - - - 0.00000000000000000000000000000006909 126.0
HFD2_k127_1799333_7 Protein of unknown function (DUF3185) - - - 0.000000000000000000000004061 102.0
HFD2_k127_1825478_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 1.261e-203 642.0
HFD2_k127_1825478_1 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 462.0
HFD2_k127_1825478_10 Bacterial regulatory proteins, tetR family K05501 - - 0.000000000000000000000000000000000000000000000000000000000000567 215.0
HFD2_k127_1825478_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000002311 151.0
HFD2_k127_1825478_12 4Fe-4S binding domain - - - 0.0000000000000000000000005139 117.0
HFD2_k127_1825478_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 446.0
HFD2_k127_1825478_3 Zinc-uptake complex component A periplasmic K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 376.0
HFD2_k127_1825478_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 347.0
HFD2_k127_1825478_5 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 316.0
HFD2_k127_1825478_6 ABC-3 protein K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006261 290.0
HFD2_k127_1825478_7 peptidase, M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002174 275.0
HFD2_k127_1825478_8 Pyrimidine 5''-nucleotidase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000002204 238.0
HFD2_k127_1825478_9 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000003598 216.0
HFD2_k127_1825676_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.401e-281 871.0
HFD2_k127_1825676_1 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 1.638e-251 789.0
HFD2_k127_1825676_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 407.0
HFD2_k127_1825676_11 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 357.0
HFD2_k127_1825676_12 response regulator K02483,K07666,K07774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 347.0
HFD2_k127_1825676_13 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000887 281.0
HFD2_k127_1825676_14 PFAM histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000008763 278.0
HFD2_k127_1825676_15 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001492 269.0
HFD2_k127_1825676_16 luxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001633 256.0
HFD2_k127_1825676_17 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000005274 182.0
HFD2_k127_1825676_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000008893 168.0
HFD2_k127_1825676_19 endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000001052 169.0
HFD2_k127_1825676_2 RecG wedge domain K03655 - 3.6.4.12 5.368e-217 698.0
HFD2_k127_1825676_20 Belongs to the N-Me-Phe pilin family K02650,K02655 - - 0.000000000000000000000000000000000000000415 154.0
HFD2_k127_1825676_21 SapC - - - 0.0000000000000000000000000000000000009993 149.0
HFD2_k127_1825676_22 response regulator K08083 - - 0.0000000000000000000000000000000009087 134.0
HFD2_k127_1825676_23 TPR repeat - - - 0.0000000000000000000000000004696 117.0
HFD2_k127_1825676_24 phosphorelay signal transduction system - - - 0.0000000000000000000503 100.0
HFD2_k127_1825676_3 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 8.384e-200 638.0
HFD2_k127_1825676_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 538.0
HFD2_k127_1825676_5 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 518.0
HFD2_k127_1825676_6 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 512.0
HFD2_k127_1825676_7 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 548.0
HFD2_k127_1825676_8 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 427.0
HFD2_k127_1825676_9 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 434.0
HFD2_k127_1827970_0 AMP-binding enzyme C-terminal domain K00666 - - 2.2e-262 826.0
HFD2_k127_1827970_1 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 567.0
HFD2_k127_1827970_10 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002469 272.0
HFD2_k127_1827970_11 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006345 267.0
HFD2_k127_1827970_12 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003577 255.0
HFD2_k127_1827970_13 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000008771 229.0
HFD2_k127_1827970_14 MaoC like domain K18290 - 4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000002776 217.0
HFD2_k127_1827970_15 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000002917 198.0
HFD2_k127_1827970_16 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000002755 170.0
HFD2_k127_1827970_17 META domain K03929 - - 0.0000000000000000000000000000000000000000001742 166.0
HFD2_k127_1827970_18 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000004277 168.0
HFD2_k127_1827970_19 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000006538 136.0
HFD2_k127_1827970_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 483.0
HFD2_k127_1827970_3 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 454.0
HFD2_k127_1827970_4 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 427.0
HFD2_k127_1827970_5 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 415.0
HFD2_k127_1827970_6 abc transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 376.0
HFD2_k127_1827970_7 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 370.0
HFD2_k127_1827970_8 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 331.0
HFD2_k127_1827970_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 294.0
HFD2_k127_18320_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.765e-197 626.0
HFD2_k127_18320_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 577.0
HFD2_k127_18320_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003709 276.0
HFD2_k127_18320_11 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002166 243.0
HFD2_k127_18320_12 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004328 238.0
HFD2_k127_18320_13 Required for insertion of 4Fe-4S clusters K15724 - - 0.00000000000000000000000000000000000000000000000000000000000009974 214.0
HFD2_k127_18320_14 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000002136 210.0
HFD2_k127_18320_15 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000000005344 197.0
HFD2_k127_18320_16 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000003018 173.0
HFD2_k127_18320_17 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000000000000000002929 171.0
HFD2_k127_18320_18 - - - - 0.0000000000000000000000000000000000000000005287 169.0
HFD2_k127_18320_19 Redoxin domain protein - - - 0.000000000000000000000000000000001578 143.0
HFD2_k127_18320_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 546.0
HFD2_k127_18320_20 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000001637 80.0
HFD2_k127_18320_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 510.0
HFD2_k127_18320_4 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 412.0
HFD2_k127_18320_5 sulfite oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 404.0
HFD2_k127_18320_6 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities K00842,K14155 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 377.0
HFD2_k127_18320_7 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 372.0
HFD2_k127_18320_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 355.0
HFD2_k127_18320_9 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 320.0
HFD2_k127_1839386_0 Protein of unknown function (DUF1254) - - - 2.723e-293 903.0
HFD2_k127_1839386_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - 8.098e-200 639.0
HFD2_k127_1839386_10 - - - - 0.000000000000000000000000000000000000000005591 160.0
HFD2_k127_1839386_11 - - - - 0.000000000000000000000000000000000002046 145.0
HFD2_k127_1839386_12 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000004477 107.0
HFD2_k127_1839386_13 lipid carrier protein - - - 0.000000000000000000007593 96.0
HFD2_k127_1839386_2 membrane protein, terc - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 494.0
HFD2_k127_1839386_3 Peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 479.0
HFD2_k127_1839386_4 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 390.0
HFD2_k127_1839386_5 Peptidase U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 339.0
HFD2_k127_1839386_6 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003201 272.0
HFD2_k127_1839386_7 diguanylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000013 246.0
HFD2_k127_1839386_8 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.00000000000000000000000000000000000000000000000000000005934 204.0
HFD2_k127_1839386_9 Formylmethanofuran dehydrogenase, subunit e - - - 0.0000000000000000000000000000000000000000000000000000007705 199.0
HFD2_k127_1851914_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.883e-227 708.0
HFD2_k127_1851914_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 6.547e-197 623.0
HFD2_k127_1851914_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000003465 132.0
HFD2_k127_1851914_2 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006071 518.0
HFD2_k127_1851914_3 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 464.0
HFD2_k127_1851914_4 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009469 464.0
HFD2_k127_1851914_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 437.0
HFD2_k127_1851914_6 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 336.0
HFD2_k127_1851914_7 cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 306.0
HFD2_k127_1851914_8 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000002631 236.0
HFD2_k127_1851914_9 phosphate transport system permease K02038 - - 0.000000000000000000000000000000000003391 140.0
HFD2_k127_1876660_0 FMN-dependent dehydrogenase K00101 GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010204,GO:0016999,GO:0017000,GO:0017144,GO:0023052,GO:0031347,GO:0031349,GO:0042579,GO:0042742,GO:0042743,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0045088,GO:0045089,GO:0048518,GO:0048583,GO:0048584,GO:0050665,GO:0050776,GO:0050778,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0072593,GO:0080134,GO:0098542,GO:1903409 1.1.2.3 4.273e-216 675.0
HFD2_k127_1876660_1 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 599.0
HFD2_k127_1876660_10 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000001476 146.0
HFD2_k127_1876660_11 glutathione transferase activity K00799 - 2.5.1.18 0.000000000000000000000000000000000679 138.0
HFD2_k127_1876660_12 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000573 124.0
HFD2_k127_1876660_13 rhamnose metabolic process - - - 0.00000000000000000000000000008377 120.0
HFD2_k127_1876660_15 Uncharacterized ACR, COG1678 - - - 0.00000000000000000000005568 108.0
HFD2_k127_1876660_16 Uncharacterized ACR, COG1678 K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000001749 108.0
HFD2_k127_1876660_17 Pkd domain containing protein - - - 0.000000000000000000000359 106.0
HFD2_k127_1876660_19 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000001867 84.0
HFD2_k127_1876660_2 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 558.0
HFD2_k127_1876660_20 cytochrome c - - - 0.000000000000001121 84.0
HFD2_k127_1876660_21 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000003937 61.0
HFD2_k127_1876660_22 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0007497 46.0
HFD2_k127_1876660_3 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 355.0
HFD2_k127_1876660_4 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 331.0
HFD2_k127_1876660_5 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 336.0
HFD2_k127_1876660_6 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 294.0
HFD2_k127_1876660_7 s cog2930 - - - 0.000000000000000000000000000000000000000000000000000000000000000001326 241.0
HFD2_k127_1876660_8 Predicted membrane protein (DUF2127) - - - 0.00000000000000000000000000000000000000000000000000000005816 206.0
HFD2_k127_1876660_9 - - - - 0.000000000000000000000000000000000000000001212 172.0
HFD2_k127_1898506_0 PFAM Cytochrome c oxidase, subunit I K02274 - 1.9.3.1 1.007e-261 816.0
HFD2_k127_1898506_1 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008323 376.0
HFD2_k127_1898506_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002085 283.0
HFD2_k127_1898506_3 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004365 267.0
HFD2_k127_1898506_4 PFAM electron transport protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000002691 244.0
HFD2_k127_1898506_5 Cytochrome b(N-terminal)/b6/petB - - - 0.000000000000000000000000000000000000000000006124 165.0
HFD2_k127_1898506_6 - - - - 0.0000000000002151 71.0
HFD2_k127_1898506_7 Uncharacterized conserved protein (DUF2249) - - - 0.00000001691 66.0
HFD2_k127_1960249_0 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 576.0
HFD2_k127_1960249_1 COG2801 Transposase and inactivated derivatives K07497 - - 0.00000000000000000000000000001916 122.0
HFD2_k127_1960249_2 DDE superfamily endonuclease - - - 0.000000000000003212 76.0
HFD2_k127_1966885_0 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 8.851e-221 696.0
HFD2_k127_1966885_1 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 604.0
HFD2_k127_1966885_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 448.0
HFD2_k127_1966885_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 306.0
HFD2_k127_1966885_4 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000002336 228.0
HFD2_k127_1966885_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000002042 158.0
HFD2_k127_1966885_6 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000001691 133.0
HFD2_k127_1966885_7 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000001222 125.0
HFD2_k127_1966885_8 general secretion pathway protein - - - 0.00001286 48.0
HFD2_k127_1967788_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 5.294e-230 737.0
HFD2_k127_1967788_1 e3 binding domain K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 452.0
HFD2_k127_1967788_10 Universal stress protein - - - 0.00000000000000000001131 108.0
HFD2_k127_1967788_11 Pfam Response regulator receiver - - - 0.000000000000000008735 89.0
HFD2_k127_1967788_2 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 449.0
HFD2_k127_1967788_3 PFAM ATP-binding region, ATPase domain protein K02486 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 317.0
HFD2_k127_1967788_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 298.0
HFD2_k127_1967788_5 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 294.0
HFD2_k127_1967788_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000003218 228.0
HFD2_k127_1967788_7 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000004038 193.0
HFD2_k127_1967788_8 COG1233 Phytoene dehydrogenase and related proteins K09516,K09835 - 1.3.99.23,5.2.1.13 0.0000000000000000000000000000000000000000000002726 173.0
HFD2_k127_1967788_9 acyl carrier protein - - - 0.000000000000000000002268 100.0
HFD2_k127_1968822_0 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 511.0
HFD2_k127_1968822_1 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002032 246.0
HFD2_k127_1968822_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000001519 71.0
HFD2_k127_198359_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 339.0
HFD2_k127_198359_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000196 104.0
HFD2_k127_2010787_0 TatD related DNase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 509.0
HFD2_k127_2010787_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K19969 - 4.2.3.152,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 497.0
HFD2_k127_2010787_2 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 432.0
HFD2_k127_2010787_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 424.0
HFD2_k127_2010787_4 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009239 317.0
HFD2_k127_2010787_5 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 293.0
HFD2_k127_2010787_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003023 273.0
HFD2_k127_2010787_7 Transmembrane family 220, helix - - - 0.000007103 54.0
HFD2_k127_2010787_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0001254 50.0
HFD2_k127_2022160_0 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1053.0
HFD2_k127_2022160_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 2.725e-273 849.0
HFD2_k127_2022160_10 YMGG-like Gly-zipper - - - 0.000000000000000000000000000000000000000000000000000000000002109 215.0
HFD2_k127_2022160_11 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000001605 229.0
HFD2_k127_2022160_12 PFAM regulatory protein, MarR - - - 0.0000000000000000000000000000000000000000000000000000005577 196.0
HFD2_k127_2022160_13 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000007419 175.0
HFD2_k127_2022160_14 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000009651 178.0
HFD2_k127_2022160_15 PFAM Cell wall hydrolase - - - 0.000000000000000000002202 107.0
HFD2_k127_2022160_16 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000002109 91.0
HFD2_k127_2022160_17 Domain of unknown function (DU1801) - - - 0.0000000000000000001253 94.0
HFD2_k127_2022160_18 O COG3187 Heat shock protein - - - 0.000004452 58.0
HFD2_k127_2022160_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K08295 - 6.2.1.32 2.83e-232 738.0
HFD2_k127_2022160_3 ribosomal rna small subunit methyltransferase - - - 3.652e-202 640.0
HFD2_k127_2022160_4 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 451.0
HFD2_k127_2022160_5 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 379.0
HFD2_k127_2022160_6 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 328.0
HFD2_k127_2022160_7 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000838 283.0
HFD2_k127_2022160_8 Membrane K08984 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002345 272.0
HFD2_k127_2022160_9 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000001115 248.0
HFD2_k127_2031164_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 1.575e-195 628.0
HFD2_k127_2031164_1 Glutaredoxin-family domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 424.0
HFD2_k127_2031164_2 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 341.0
HFD2_k127_2031164_3 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 336.0
HFD2_k127_2031164_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 317.0
HFD2_k127_2031164_5 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001391 249.0
HFD2_k127_2031164_6 Flavin reductase like domain - - - 0.0000000000000000000000000000000002553 139.0
HFD2_k127_2032247_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1227.0
HFD2_k127_2032247_1 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 597.0
HFD2_k127_2032247_10 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000000009727 182.0
HFD2_k127_2032247_11 Modulates RecA activity K03565 - - 0.000000000000000000002347 100.0
HFD2_k127_2032247_12 - - - - 0.0000000000008622 74.0
HFD2_k127_2032247_13 Sulfite exporter TauE/SafE K07090 - - 0.000000000002161 77.0
HFD2_k127_2032247_14 Belongs to the CinA family K03743 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 0.00000003113 55.0
HFD2_k127_2032247_15 Sel1-like repeats. - - - 0.000002752 54.0
HFD2_k127_2032247_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 555.0
HFD2_k127_2032247_3 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 434.0
HFD2_k127_2032247_4 Dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 410.0
HFD2_k127_2032247_5 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 398.0
HFD2_k127_2032247_6 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 381.0
HFD2_k127_2032247_7 auxin efflux carrier K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000336 290.0
HFD2_k127_2032247_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001955 250.0
HFD2_k127_2032247_9 PFAM NUDIX hydrolase K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000001272 204.0
HFD2_k127_2060657_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 2.043e-305 960.0
HFD2_k127_2060657_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 509.0
HFD2_k127_2060657_10 PFAM Mammalian cell entry related domain protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000002217 228.0
HFD2_k127_2060657_11 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000491 213.0
HFD2_k127_2060657_12 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000007002 217.0
HFD2_k127_2060657_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000003536 166.0
HFD2_k127_2060657_14 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000000000000000000000001319 175.0
HFD2_k127_2060657_15 MerR HTH family regulatory protein K18997 - - 0.000000000000000000000003141 113.0
HFD2_k127_2060657_16 Protein of unknown function (DUF3301) - - - 0.0000000000000000000002561 100.0
HFD2_k127_2060657_17 - - - - 0.0000000976 57.0
HFD2_k127_2060657_2 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 486.0
HFD2_k127_2060657_3 heat shock protein DnaJ K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 453.0
HFD2_k127_2060657_4 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 458.0
HFD2_k127_2060657_5 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 406.0
HFD2_k127_2060657_6 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 394.0
HFD2_k127_2060657_7 Abc transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 372.0
HFD2_k127_2060657_8 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 349.0
HFD2_k127_2060657_9 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000001546 218.0
HFD2_k127_2127010_0 ATP cone domain K21636 - 1.1.98.6 0.0 1140.0
HFD2_k127_2127010_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.372e-230 722.0
HFD2_k127_2127010_2 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000522 467.0
HFD2_k127_2127010_3 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 433.0
HFD2_k127_2127010_4 COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 361.0
HFD2_k127_2127010_5 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000713 215.0
HFD2_k127_2179272_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 343.0
HFD2_k127_2179272_1 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 326.0
HFD2_k127_2179272_2 CoA binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000001255 231.0
HFD2_k127_2179272_3 - - - - 0.00000000000000000000000000000000000000000000000002466 187.0
HFD2_k127_2179272_4 Thioesterase superfamily protein - - - 0.0000000000000000004199 100.0
HFD2_k127_2196357_0 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 579.0
HFD2_k127_2196357_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007215 359.0
HFD2_k127_2196357_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 291.0
HFD2_k127_2275333_0 Belongs to the thiolase family K00626 - 2.3.1.9 1.799e-204 646.0
HFD2_k127_2275333_1 acyl-CoA dehydrogenase K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 571.0
HFD2_k127_2275333_2 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007878 511.0
HFD2_k127_2291211_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 3.232e-208 674.0
HFD2_k127_2291211_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000972 282.0
HFD2_k127_2291211_2 Universal stress protein family - - - 0.000000000000000000000000000000000000000000006443 167.0
HFD2_k127_2296139_0 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 539.0
HFD2_k127_2296139_1 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 500.0
HFD2_k127_2296139_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000007865 149.0
HFD2_k127_2296139_11 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000001095 115.0
HFD2_k127_2296139_12 DinB superfamily - - - 0.000001013 52.0
HFD2_k127_2296139_13 Dioxygenases related to 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.000004891 55.0
HFD2_k127_2296139_2 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 436.0
HFD2_k127_2296139_3 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 415.0
HFD2_k127_2296139_4 TRAP transporter solute receptor TAXI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 368.0
HFD2_k127_2296139_5 Catechol dioxygenase N terminus K04098 - 1.13.11.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 348.0
HFD2_k127_2296139_6 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 345.0
HFD2_k127_2296139_7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000006404 269.0
HFD2_k127_2296139_8 protocatechuate 3,4-dioxygenase, beta subunit K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000002981 239.0
HFD2_k127_2296139_9 protocatechuate 3,4-dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000007251 175.0
HFD2_k127_2304576_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.125e-301 947.0
HFD2_k127_2304576_1 Exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 535.0
HFD2_k127_2304576_2 TIGRFAM type I secretion membrane fusion protein, HlyD K02022,K11003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 479.0
HFD2_k127_2304576_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 355.0
HFD2_k127_2304576_4 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.000000000000000000000000000000000000000000000000000000000000006759 221.0
HFD2_k127_2304576_5 phosphohistidine phosphatase K08296 - - 0.00000000000000000000000000000000000000000902 158.0
HFD2_k127_2304576_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000005673 93.0
HFD2_k127_233295_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 2457.0
HFD2_k127_233295_1 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 495.0
HFD2_k127_233295_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000006633 267.0
HFD2_k127_233295_3 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.0000000000000000003501 102.0
HFD2_k127_236374_0 ATPase (P-type) K01535 - 3.6.3.6 0.0 1174.0
HFD2_k127_236374_1 Tripartite tricarboxylate transporter TctA family - - - 4.312e-228 715.0
HFD2_k127_236374_10 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001383 278.0
HFD2_k127_236374_11 Adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000006991 252.0
HFD2_k127_236374_12 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000000000005992 217.0
HFD2_k127_236374_13 NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000001983 186.0
HFD2_k127_236374_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000002965 194.0
HFD2_k127_236374_15 oxidation-reduction process - - - 0.00000000000000000000000000000000000000000000000006569 181.0
HFD2_k127_236374_16 Biopolymer transport protein ExbD TolR K03559 - - 0.000000000000000000000000000000000000000000772 160.0
HFD2_k127_236374_17 - - - - 0.00000000000000000000000000000000000000003323 160.0
HFD2_k127_236374_18 ACT domain protein K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.000000000000000000000000000000000001189 143.0
HFD2_k127_236374_19 Anti-sigma-K factor rskA - - - 0.000000000000000000000000000000000005551 153.0
HFD2_k127_236374_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 426.0
HFD2_k127_236374_20 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000008191 119.0
HFD2_k127_236374_21 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000008014 113.0
HFD2_k127_236374_22 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000001866 97.0
HFD2_k127_236374_23 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000001134 89.0
HFD2_k127_236374_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 384.0
HFD2_k127_236374_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 332.0
HFD2_k127_236374_5 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 314.0
HFD2_k127_236374_6 haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 317.0
HFD2_k127_236374_7 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 326.0
HFD2_k127_236374_8 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 310.0
HFD2_k127_236374_9 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 289.0
HFD2_k127_2454929_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1310.0
HFD2_k127_2454929_1 pilus assembly protein tip-associated adhesin K02674 - - 3.199e-271 894.0
HFD2_k127_2454929_10 Pilus assembly protein PilX - - - 0.0000000000000000000000006687 121.0
HFD2_k127_2454929_11 Histidine kinase - - - 0.00000000000000000000001333 105.0
HFD2_k127_2454929_12 type IV pilus modification protein PilV K02671 - - 0.0000000000000007273 83.0
HFD2_k127_2454929_13 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000004197 70.0
HFD2_k127_2454929_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 481.0
HFD2_k127_2454929_3 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 324.0
HFD2_k127_2454929_4 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000002817 242.0
HFD2_k127_2454929_5 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000009813 171.0
HFD2_k127_2454929_6 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000002267 161.0
HFD2_k127_2454929_7 Type II transport protein GspH K08084 - - 0.000000000000000000000000000000000000000006471 169.0
HFD2_k127_2454929_8 General secretion pathway protein K02459,K02672,K02680 - - 0.0000000000000000000000000000000000000009423 166.0
HFD2_k127_2454929_9 Tfp pilus assembly protein K02655 - - 0.0000000000000000000000001931 113.0
HFD2_k127_2469527_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K04116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 550.0
HFD2_k127_2469527_1 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 473.0
HFD2_k127_2469527_2 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 365.0
HFD2_k127_2469527_3 KR domain K07535 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 349.0
HFD2_k127_2469527_4 histidine kinase HAMP region domain protein K03406,K07216 - - 0.00000000000001396 81.0
HFD2_k127_2469527_5 Acetyltransferase (GNAT) family - - - 0.00000001415 57.0
HFD2_k127_2479706_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1333.0
HFD2_k127_2479706_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 530.0
HFD2_k127_2479706_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 512.0
HFD2_k127_2479706_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 466.0
HFD2_k127_2479706_4 chorismate mutase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 420.0
HFD2_k127_2479706_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009683 403.0
HFD2_k127_2479706_6 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006278 310.0
HFD2_k127_2479706_7 OmpA family K03286 - - 0.00000000000000000000000000004141 123.0
HFD2_k127_2481974_0 MlaD protein K02067 - - 0.00000000000000000000000000000001133 144.0
HFD2_k127_2481974_1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000005228 133.0
HFD2_k127_2481974_2 ABC transporter - - - 0.0000006358 62.0
HFD2_k127_2498155_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 4.199e-209 680.0
HFD2_k127_2498155_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 539.0
HFD2_k127_2498155_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 488.0
HFD2_k127_2498155_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 359.0
HFD2_k127_2498155_4 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000005245 195.0
HFD2_k127_2498155_5 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000007853 212.0
HFD2_k127_2498155_6 ChrR Cupin-like domain - - - 0.00000000000000000000000000000000000000000000000007167 181.0
HFD2_k127_2498155_7 membrane - - - 0.00000000000000000000000000000000000000001008 171.0
HFD2_k127_2526107_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 327.0
HFD2_k127_2526107_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 310.0
HFD2_k127_2526107_2 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000000000000005681 221.0
HFD2_k127_2526107_3 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000004375 219.0
HFD2_k127_2526107_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000000000007239 124.0
HFD2_k127_2575031_0 Amidohydrolase family - - - 2.621e-225 709.0
HFD2_k127_2575031_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 496.0
HFD2_k127_2575031_2 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 382.0
HFD2_k127_2575031_3 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007031 265.0
HFD2_k127_2575031_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004227 258.0
HFD2_k127_2575031_5 KR domain K13774 - - 0.000000000000000000000000000000000000000000000000000000001882 216.0
HFD2_k127_2575031_6 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000009941 200.0
HFD2_k127_2575031_7 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000002018 158.0
HFD2_k127_2575031_8 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000000000000000000000001236 148.0
HFD2_k127_2575031_9 O-methyltransferase K21460 - 2.1.1.304 0.00000000000000000001529 96.0
HFD2_k127_259540_0 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 425.0
HFD2_k127_259540_1 methyltransferase activity - - - 0.0000000000000000000000000000000000000002229 158.0
HFD2_k127_259540_2 Short-chain dehydrogenase reductase Sdr - - - 0.0000000000000000000000000001473 119.0
HFD2_k127_259540_3 Tripartite tricarboxylate transporter TctB family - - - 0.00000000001036 70.0
HFD2_k127_2641747_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 544.0
HFD2_k127_2641747_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 551.0
HFD2_k127_2641747_10 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K03438,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000001328 237.0
HFD2_k127_2641747_11 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000003205 160.0
HFD2_k127_2641747_12 Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000008521 139.0
HFD2_k127_2641747_13 thioesterase K07107 - - 0.0000000000000000000000000000000001041 141.0
HFD2_k127_2641747_14 OmpA-like transmembrane domain - - - 0.0003002 53.0
HFD2_k127_2641747_15 TonB C terminal K03646 - - 0.0004065 53.0
HFD2_k127_2641747_2 Aldehyde dehydrogenase family K00141 - 1.2.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 497.0
HFD2_k127_2641747_3 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 374.0
HFD2_k127_2641747_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 376.0
HFD2_k127_2641747_5 Beta-lactamase class C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 344.0
HFD2_k127_2641747_6 MotA TolQ ExbB proton channel family K03561,K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 313.0
HFD2_k127_2641747_7 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001694 254.0
HFD2_k127_2641747_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002431 270.0
HFD2_k127_2641747_9 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000004817 244.0
HFD2_k127_2679397_0 Aminotransferase class I and II K14261 - - 1.867e-225 702.0
HFD2_k127_2679397_1 homoserine dehydrogenase K00003 - 1.1.1.3 8.524e-200 651.0
HFD2_k127_2679397_10 PFAM formyl transferase domain protein K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 340.0
HFD2_k127_2679397_11 Redoxin K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000005325 231.0
HFD2_k127_2679397_12 Small Multidrug Resistance protein - - - 0.00000000000000000000000000000000000000000000001669 175.0
HFD2_k127_2679397_13 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000004695 139.0
HFD2_k127_2679397_2 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 1.937e-195 617.0
HFD2_k127_2679397_3 Nad-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 553.0
HFD2_k127_2679397_4 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 549.0
HFD2_k127_2679397_5 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 512.0
HFD2_k127_2679397_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 445.0
HFD2_k127_2679397_7 Glycosyl transferase family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 419.0
HFD2_k127_2679397_8 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 372.0
HFD2_k127_2679397_9 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 364.0
HFD2_k127_2741429_0 FAD linked oxidase domain protein K06911 - - 2.676e-297 930.0
HFD2_k127_2741429_1 transport system fused permease components - - - 6.362e-229 725.0
HFD2_k127_2741429_10 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002685 267.0
HFD2_k127_2741429_11 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001306 255.0
HFD2_k127_2741429_12 2-Keto-4-pentenoate hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001433 245.0
HFD2_k127_2741429_13 Protein of unknown function (DUF1223) - - - 0.0000000000000000000000000000000000000000000000000000000000009722 219.0
HFD2_k127_2741429_14 high-affinity ferrous iron transmembrane transporter activity K07243 - - 0.00000000000000000000000000000000000000000000001826 179.0
HFD2_k127_2741429_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000001014 132.0
HFD2_k127_2741429_16 spectrin binding - - - 0.0000000000000007928 93.0
HFD2_k127_2741429_17 NfeD-like C-terminal, partner-binding - - - 0.0000000000005658 76.0
HFD2_k127_2741429_18 Hemin uptake protein - - - 0.00001976 48.0
HFD2_k127_2741429_19 DNA-sulfur modification-associated - - - 0.00004578 55.0
HFD2_k127_2741429_2 CoA-transferase family III K18289 - 2.8.3.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 487.0
HFD2_k127_2741429_3 SMART band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 387.0
HFD2_k127_2741429_4 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009294 378.0
HFD2_k127_2741429_5 luciferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 367.0
HFD2_k127_2741429_6 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K22229 - 1.1.1.215 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 346.0
HFD2_k127_2741429_7 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 324.0
HFD2_k127_2741429_8 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 310.0
HFD2_k127_2741429_9 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 290.0
HFD2_k127_2760643_0 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 387.0
HFD2_k127_2760643_1 Class ii aldolase K01628,K03077 - 4.1.2.17,5.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 329.0
HFD2_k127_2760643_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 331.0
HFD2_k127_2760643_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001783 296.0
HFD2_k127_2760643_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000001511 255.0
HFD2_k127_2798578_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 598.0
HFD2_k127_2798578_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 514.0
HFD2_k127_2798578_2 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005805 281.0
HFD2_k127_2798578_3 CHASE3 domain - - - 0.00000000000003096 73.0
HFD2_k127_2798578_4 - - - - 0.00000004805 58.0
HFD2_k127_2811961_0 Putative Na+/H+ antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 476.0
HFD2_k127_2811961_1 Cupin 2, conserved barrel domain protein K21700 - - 0.0000000000000000000000000000003534 126.0
HFD2_k127_2811961_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000001726 75.0
HFD2_k127_2822263_0 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003467 248.0
HFD2_k127_2826096_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 581.0
HFD2_k127_2826096_1 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 571.0
HFD2_k127_2826096_2 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 365.0
HFD2_k127_2826096_3 Ferredoxin K05337 - - 0.000000000000000000000000000000000000001572 149.0
HFD2_k127_2826096_4 Methylmuconolactone methyl-isomerase - - - 0.000000000000000000000000000004142 130.0
HFD2_k127_2827950_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 361.0
HFD2_k127_2827950_1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000001694 126.0
HFD2_k127_2830648_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 9.579e-261 815.0
HFD2_k127_2830648_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 450.0
HFD2_k127_2830648_2 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002283 262.0
HFD2_k127_2830648_3 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000112 214.0
HFD2_k127_2830648_4 - - - - 0.0000000000000000000000000000000000000000000000002026 180.0
HFD2_k127_2830648_5 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000005978 178.0
HFD2_k127_2830648_6 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000009203 113.0
HFD2_k127_2860527_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1442.0
HFD2_k127_2860527_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1193.0
HFD2_k127_2860527_10 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 345.0
HFD2_k127_2860527_11 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 331.0
HFD2_k127_2860527_12 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 344.0
HFD2_k127_2860527_13 CO dehydrogenase flavoprotein C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 318.0
HFD2_k127_2860527_14 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 315.0
HFD2_k127_2860527_15 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K10715 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 304.0
HFD2_k127_2860527_16 Proline racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009257 271.0
HFD2_k127_2860527_17 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001275 261.0
HFD2_k127_2860527_18 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000001828 269.0
HFD2_k127_2860527_19 asparaginase K01424,K13051 GO:0003674,GO:0003824,GO:0004067,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008798,GO:0010467,GO:0016485,GO:0016540,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.19.5,3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002376 263.0
HFD2_k127_2860527_2 Hydantoinase/oxoprolinase - - - 1.145e-286 905.0
HFD2_k127_2860527_20 COG2202 FOG PAS PAC domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000124 267.0
HFD2_k127_2860527_21 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000002454 264.0
HFD2_k127_2860527_22 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001529 249.0
HFD2_k127_2860527_23 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006105 252.0
HFD2_k127_2860527_24 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003288 239.0
HFD2_k127_2860527_25 Macrocin-O-methyltransferase (TylF) K05303 - - 0.000000000000000000000000000000000000000000000000000000000000000003384 240.0
HFD2_k127_2860527_26 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000001123 251.0
HFD2_k127_2860527_27 AsmA-like C-terminal region - - - 0.00000000000000000000000000000000000000000001678 188.0
HFD2_k127_2860527_28 Bacterial DNA polymerase III alpha subunit K14162 - 2.7.7.7 0.000000000000000000000000000000000001006 140.0
HFD2_k127_2860527_29 cheY-homologous receiver domain - - - 0.00000000000000000000000000001127 132.0
HFD2_k127_2860527_3 Hydantoinase B/oxoprolinase - - - 5.722e-284 880.0
HFD2_k127_2860527_30 PFAM Hpt domain protein - - - 0.000000000000000000008783 95.0
HFD2_k127_2860527_31 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000003642 102.0
HFD2_k127_2860527_33 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.000000005121 62.0
HFD2_k127_2860527_4 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 2.467e-258 810.0
HFD2_k127_2860527_5 COG1180 Pyruvate-formate lyase-activating enzyme K20449 - 1.3.7.1 3.751e-235 734.0
HFD2_k127_2860527_6 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 584.0
HFD2_k127_2860527_7 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 553.0
HFD2_k127_2860527_8 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 406.0
HFD2_k127_2860527_9 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 394.0
HFD2_k127_2872945_0 GTP-binding protein K06207 - - 3.41e-314 971.0
HFD2_k127_2872945_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 2.204e-310 957.0
HFD2_k127_2872945_10 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 416.0
HFD2_k127_2872945_11 histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 414.0
HFD2_k127_2872945_12 Rhodanese Homology Domain K06917 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 386.0
HFD2_k127_2872945_13 Permease, YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 376.0
HFD2_k127_2872945_14 Permease YjgP YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 366.0
HFD2_k127_2872945_15 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 346.0
HFD2_k127_2872945_16 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008276 312.0
HFD2_k127_2872945_17 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 331.0
HFD2_k127_2872945_18 NADPH-dependent FMN reductase K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 301.0
HFD2_k127_2872945_19 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 302.0
HFD2_k127_2872945_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 6.792e-248 777.0
HFD2_k127_2872945_20 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000001377 271.0
HFD2_k127_2872945_21 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005118 256.0
HFD2_k127_2872945_22 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000001463 277.0
HFD2_k127_2872945_23 Acetolactate synthase small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000005244 256.0
HFD2_k127_2872945_24 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000007041 233.0
HFD2_k127_2872945_25 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000002872 218.0
HFD2_k127_2872945_26 dna polymerase III (Chi subunit) K02339 - 2.7.7.7 0.00000000000000000000000000000000005865 148.0
HFD2_k127_2872945_27 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000001503 124.0
HFD2_k127_2872945_28 ThiS family - - - 0.0000000000000000000000000003105 117.0
HFD2_k127_2872945_29 RDD family - - - 0.000000000000000000000000004372 119.0
HFD2_k127_2872945_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 604.0
HFD2_k127_2872945_30 Protein of unknown function (DUF3106) - - - 0.0000000000000000000000009359 110.0
HFD2_k127_2872945_31 transcriptional regulator - - - 0.0000000000000002246 82.0
HFD2_k127_2872945_32 Protein of unknown function (DUF3619) - - - 0.00000000000004433 77.0
HFD2_k127_2872945_4 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 565.0
HFD2_k127_2872945_5 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003724 544.0
HFD2_k127_2872945_6 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000594 551.0
HFD2_k127_2872945_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 503.0
HFD2_k127_2872945_8 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 477.0
HFD2_k127_2872945_9 PFAM Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 472.0
HFD2_k127_2908361_0 Cytochrome D1 heme domain K15864 - 1.7.2.1,1.7.99.1 1.593e-296 918.0
HFD2_k127_2908361_1 Cytochrome c554 and c-prime - - - 2.197e-240 769.0
HFD2_k127_2908361_2 Two-component sensor kinase N-terminal K07645 - 2.7.13.3 0.00000000000000000000000000000000001383 141.0
HFD2_k127_2908361_3 Cytochrome c K08738 - - 0.0000000000000000000000000000003074 126.0
HFD2_k127_2908361_4 Uncharacterized conserved protein (DUF2249) - - - 0.00001872 47.0
HFD2_k127_2916218_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 6.647e-239 751.0
HFD2_k127_2916218_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 552.0
HFD2_k127_2916218_10 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 356.0
HFD2_k127_2916218_11 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 365.0
HFD2_k127_2916218_12 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 313.0
HFD2_k127_2916218_13 VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009148 264.0
HFD2_k127_2916218_14 ATPase activity, coupled to transmembrane movement of substances - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003531 252.0
HFD2_k127_2916218_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007049 262.0
HFD2_k127_2916218_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000005614 243.0
HFD2_k127_2916218_17 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000002835 216.0
HFD2_k127_2916218_18 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.00000000000000000000000000000000000000000000000000000000001996 215.0
HFD2_k127_2916218_19 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000007249 208.0
HFD2_k127_2916218_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 559.0
HFD2_k127_2916218_21 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000001545 168.0
HFD2_k127_2916218_22 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000008246 156.0
HFD2_k127_2916218_23 general secretion pathway protein - - - 0.000000000000000000000000000000003709 147.0
HFD2_k127_2916218_24 Belongs to the BolA IbaG family - - - 0.000000000000000000000001653 117.0
HFD2_k127_2916218_25 - - - - 0.0000000000000001445 87.0
HFD2_k127_2916218_26 - - - - 0.00000000000001345 85.0
HFD2_k127_2916218_27 transporter antisigma-factor antagonist STAS K07122 - - 0.00000000007309 74.0
HFD2_k127_2916218_3 type II secretion system protein K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 500.0
HFD2_k127_2916218_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006344 486.0
HFD2_k127_2916218_5 Type II and III secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 464.0
HFD2_k127_2916218_6 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 466.0
HFD2_k127_2916218_7 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008707 406.0
HFD2_k127_2916218_8 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 391.0
HFD2_k127_2916218_9 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 364.0
HFD2_k127_2992500_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1285.0
HFD2_k127_2992500_1 TIGRFAM ATP-dependent Clp protease ATP-binding subunit clpA K03694 - - 0.0 1188.0
HFD2_k127_2992500_10 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 494.0
HFD2_k127_2992500_11 Domain of unknown function DUF21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 451.0
HFD2_k127_2992500_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 446.0
HFD2_k127_2992500_13 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 430.0
HFD2_k127_2992500_14 PFAM FAD linked oxidase domain protein K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 410.0
HFD2_k127_2992500_15 ATPase (AAA superfamily) K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 389.0
HFD2_k127_2992500_16 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 382.0
HFD2_k127_2992500_17 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 367.0
HFD2_k127_2992500_18 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 353.0
HFD2_k127_2992500_19 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 344.0
HFD2_k127_2992500_2 Isocitrate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 2.536e-222 696.0
HFD2_k127_2992500_20 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 334.0
HFD2_k127_2992500_21 Xylose isomerase-like TIM barrel K01816 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0008903,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019752,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0046983,GO:0071704 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 329.0
HFD2_k127_2992500_22 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 289.0
HFD2_k127_2992500_23 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 283.0
HFD2_k127_2992500_24 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006881 267.0
HFD2_k127_2992500_25 PFAM Cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002658 268.0
HFD2_k127_2992500_26 Formyl transferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000005015 264.0
HFD2_k127_2992500_27 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000015 259.0
HFD2_k127_2992500_28 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006533 243.0
HFD2_k127_2992500_29 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000000002325 236.0
HFD2_k127_2992500_3 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 9.978e-216 680.0
HFD2_k127_2992500_30 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000003723 227.0
HFD2_k127_2992500_31 Cytochrome c, class I - - - 0.00000000000000000000000000000000000000000000000000004556 199.0
HFD2_k127_2992500_32 Phasin protein - - - 0.000000000000000000000000000000000000000000000000005071 186.0
HFD2_k127_2992500_33 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000001845 179.0
HFD2_k127_2992500_34 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000004151 165.0
HFD2_k127_2992500_35 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000002201 166.0
HFD2_k127_2992500_36 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000001136 119.0
HFD2_k127_2992500_37 Cytochrome c, class I - - - 0.00000000000000000000004721 101.0
HFD2_k127_2992500_38 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000162 95.0
HFD2_k127_2992500_39 Protein of unknown function (DUF3108) - - - 0.00000000000000000993 94.0
HFD2_k127_2992500_4 type II secretion system protein K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 600.0
HFD2_k127_2992500_40 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000002658 86.0
HFD2_k127_2992500_41 Cold shock protein K03704 - - 0.00000000000007684 73.0
HFD2_k127_2992500_42 COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000001203 65.0
HFD2_k127_2992500_43 Cold shock protein K03704 - - 0.0000000002117 61.0
HFD2_k127_2992500_5 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005297 600.0
HFD2_k127_2992500_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 597.0
HFD2_k127_2992500_7 PFAM fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 558.0
HFD2_k127_2992500_8 Flavocytochrome c sulphide dehydrogenase, flavin-binding K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 518.0
HFD2_k127_2992500_9 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 504.0
HFD2_k127_300078_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 1.801e-269 866.0
HFD2_k127_300078_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 514.0
HFD2_k127_300078_2 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004067 368.0
HFD2_k127_300078_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000174 203.0
HFD2_k127_300078_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000000000000004423 190.0
HFD2_k127_300078_5 PFAM regulatory protein, MerR - - - 0.0000000000000000000000000000000000000000000000008976 177.0
HFD2_k127_300078_6 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000000000000000001229 175.0
HFD2_k127_300078_7 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000004224 173.0
HFD2_k127_300078_8 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000009195 90.0
HFD2_k127_300078_9 dehydrogenase - - - 0.0002123 47.0
HFD2_k127_3007373_0 sulfite reductase, dissimilatory-type alpha subunit K11180 - 1.8.99.5 4.089e-225 703.0
HFD2_k127_3007373_1 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 2.356e-215 672.0
HFD2_k127_3007373_10 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000000000000000000000004019 194.0
HFD2_k127_3007373_11 Sulfur relay protein TusC DsrF K07236 - - 0.0000000000000000000000000000000000000000000000002651 185.0
HFD2_k127_3007373_12 - - - - 0.0000000000000000000000000000000000000000000000005412 190.0
HFD2_k127_3007373_13 Sulfurtransferase TusA - - - 0.0000000000000000000000000000000000000000000001826 178.0
HFD2_k127_3007373_14 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000004675 161.0
HFD2_k127_3007373_15 DsrH like protein K07237 - - 0.00000000000000000000000000000000005654 138.0
HFD2_k127_3007373_16 part of a sulfur-relay system K11179 - - 0.00000000000000000000000000000001607 130.0
HFD2_k127_3007373_17 Sulfurtransferase TusA K04085 - - 0.00000000000000000000000000000004243 128.0
HFD2_k127_3007373_18 part of a sulfur-relay system K11179 - - 0.0000000000000000000000000000004169 138.0
HFD2_k127_3007373_19 Cas6 Crispr - - - 0.000000000000000000000000000003785 128.0
HFD2_k127_3007373_2 4Fe-4S dicluster domain - - - 5.71e-204 652.0
HFD2_k127_3007373_20 - - - - 0.0000000000000000001468 91.0
HFD2_k127_3007373_21 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000007538 86.0
HFD2_k127_3007373_22 SCP-2 sterol transfer family - - - 0.00000000003845 66.0
HFD2_k127_3007373_3 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 469.0
HFD2_k127_3007373_4 Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007835 365.0
HFD2_k127_3007373_5 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 327.0
HFD2_k127_3007373_6 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 295.0
HFD2_k127_3007373_7 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000474 255.0
HFD2_k127_3007373_8 part of a sulfur-relay system K11179 - - 0.0000000000000000000000000000000000000000000000000000001312 196.0
HFD2_k127_3007373_9 sulfur relay protein TusD DsrE K07235 - - 0.0000000000000000000000000000000000000000000000000000001457 208.0
HFD2_k127_3035365_0 Domain of unknown function (DUF3394) - - - 1.174e-297 927.0
HFD2_k127_3035365_1 Fumarate reductase flavoprotein C-term K00239,K00244 - 1.3.5.1,1.3.5.4 1.017e-278 865.0
HFD2_k127_3035365_10 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 448.0
HFD2_k127_3035365_11 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 443.0
HFD2_k127_3035365_12 pdz dhr glgf - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 444.0
HFD2_k127_3035365_13 phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 447.0
HFD2_k127_3035365_14 Tartrate K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 435.0
HFD2_k127_3035365_15 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 420.0
HFD2_k127_3035365_16 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 387.0
HFD2_k127_3035365_17 Tyrosine recombinase XerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 368.0
HFD2_k127_3035365_18 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 353.0
HFD2_k127_3035365_19 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 344.0
HFD2_k127_3035365_2 D-galactarate dehydratase K16846,K16850 - 4.2.1.7,4.4.1.24 3.663e-208 657.0
HFD2_k127_3035365_20 Belongs to the LDH2 MDH2 oxidoreductase family K13609,K16844 - 1.1.1.338,1.5.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000864 347.0
HFD2_k127_3035365_21 Fumarase C-terminus K01678,K03780 - 4.2.1.2,4.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005207 327.0
HFD2_k127_3035365_22 Histidine kinase K07673 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 334.0
HFD2_k127_3035365_23 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 343.0
HFD2_k127_3035365_24 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 330.0
HFD2_k127_3035365_25 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 310.0
HFD2_k127_3035365_26 oxidoreductase FAD NAD(P)-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002319 281.0
HFD2_k127_3035365_27 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004489 290.0
HFD2_k127_3035365_28 response regulator K07684 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003911 272.0
HFD2_k127_3035365_29 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.00000000000000000000000000000000000000000000000000000000000000000008016 233.0
HFD2_k127_3035365_3 Peptidase family M1 domain - - - 4.426e-206 679.0
HFD2_k127_3035365_30 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000001248 239.0
HFD2_k127_3035365_31 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000133 231.0
HFD2_k127_3035365_32 - - - - 0.000000000000000000000000000000000000000000000000000000002476 209.0
HFD2_k127_3035365_33 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000002504 210.0
HFD2_k127_3035365_34 Conserved Protein - - - 0.000000000000000000000000000000000000000000000000000000003882 209.0
HFD2_k127_3035365_35 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000000001515 194.0
HFD2_k127_3035365_36 Alkaline phosphatase K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000003578 192.0
HFD2_k127_3035365_37 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000007319 192.0
HFD2_k127_3035365_38 Haem-degrading - - - 0.000000000000000000000000000000000000000000000000001149 189.0
HFD2_k127_3035365_39 COG0350 Methylated DNA-protein cysteine methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000001856 170.0
HFD2_k127_3035365_4 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 573.0
HFD2_k127_3035365_40 acetyltransferase - - - 0.0000000000000000000000000000000000000003839 160.0
HFD2_k127_3035365_41 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000001645 132.0
HFD2_k127_3035365_42 4Fe-4S binding domain K00184 - - 0.000000000000000000000000000005492 119.0
HFD2_k127_3035365_43 succinate dehydrogenase K00247 - - 0.0000000000000000000000000002373 123.0
HFD2_k127_3035365_44 succinate dehydrogenase K00246 - - 0.0000000000000000000000000003749 126.0
HFD2_k127_3035365_45 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000005652 124.0
HFD2_k127_3035365_46 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 0.000000000009747 68.0
HFD2_k127_3035365_48 - - - - 0.0001846 49.0
HFD2_k127_3035365_5 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 518.0
HFD2_k127_3035365_6 N-terminal domain of oxidoreductase K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 477.0
HFD2_k127_3035365_7 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005252 471.0
HFD2_k127_3035365_8 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 467.0
HFD2_k127_3035365_9 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 464.0
HFD2_k127_304274_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 1.613e-256 806.0
HFD2_k127_304274_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 1.591e-254 790.0
HFD2_k127_304274_10 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000003364 280.0
HFD2_k127_304274_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001073 244.0
HFD2_k127_304274_12 glycosyl transferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000008756 233.0
HFD2_k127_304274_13 Protein of unknown function (DUF3025) - - - 0.00000000000000000000000000000000000000000000000007218 198.0
HFD2_k127_304274_14 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000001201 147.0
HFD2_k127_304274_15 HIRAN - - - 0.000000000000000000000000000000004809 132.0
HFD2_k127_304274_16 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000000000001095 124.0
HFD2_k127_304274_17 PAS fold - - - 0.0001057 51.0
HFD2_k127_304274_2 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 611.0
HFD2_k127_304274_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 575.0
HFD2_k127_304274_4 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 540.0
HFD2_k127_304274_5 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 499.0
HFD2_k127_304274_6 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006682 485.0
HFD2_k127_304274_7 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 417.0
HFD2_k127_304274_8 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001632 282.0
HFD2_k127_304274_9 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001107 303.0
HFD2_k127_3047209_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1219.0
HFD2_k127_3047209_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 519.0
HFD2_k127_3047209_10 Thioesterase - - - 0.0000000000000000000000000000000000000001355 158.0
HFD2_k127_3047209_11 transcriptional regulator - - - 0.00000000000000000000000001513 111.0
HFD2_k127_3047209_2 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 505.0
HFD2_k127_3047209_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 385.0
HFD2_k127_3047209_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 359.0
HFD2_k127_3047209_5 COG0437 Fe-S-cluster-containing hydrogenase components 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 335.0
HFD2_k127_3047209_6 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
HFD2_k127_3047209_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004964 271.0
HFD2_k127_3047209_8 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000002966 162.0
HFD2_k127_3047209_9 DMSO reductase anchor subunit (DmsC) K18363 - - 0.0000000000000000000000000000000000000000297 169.0
HFD2_k127_3050097_0 MltA-interacting protein MipA K07274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 416.0
HFD2_k127_3050097_1 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 396.0
HFD2_k127_3050097_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 366.0
HFD2_k127_3050097_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000007523 166.0
HFD2_k127_3219383_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1513.0
HFD2_k127_3219383_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 394.0
HFD2_k127_3219383_2 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000002986 177.0
HFD2_k127_3219383_3 - - - - 0.00000000000000000000000000000000000000123 152.0
HFD2_k127_3219383_4 - - - - 0.00000000000000000000000002781 117.0
HFD2_k127_3219383_5 - - - - 0.00000004143 59.0
HFD2_k127_3233324_0 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 510.0
HFD2_k127_3233324_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 476.0
HFD2_k127_3233324_10 Flavoprotein involved in K transport K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000176 280.0
HFD2_k127_3233324_11 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001761 278.0
HFD2_k127_3233324_12 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002087 278.0
HFD2_k127_3233324_13 Nitrile hydratase K01721,K20807 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000001659 260.0
HFD2_k127_3233324_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000139 199.0
HFD2_k127_3233324_15 Membrane dipeptidase (Peptidase family M19) - - - 0.00000000000000000000000000000000000000000000000003632 202.0
HFD2_k127_3233324_16 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000000000000000000000007309 145.0
HFD2_k127_3233324_17 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000002225 106.0
HFD2_k127_3233324_18 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.0000000000000000000003629 100.0
HFD2_k127_3233324_2 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 434.0
HFD2_k127_3233324_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 378.0
HFD2_k127_3233324_4 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 379.0
HFD2_k127_3233324_5 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 351.0
HFD2_k127_3233324_6 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003666 338.0
HFD2_k127_3233324_7 Secretion protein K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 299.0
HFD2_k127_3233324_8 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000785 299.0
HFD2_k127_3233324_9 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001703 280.0
HFD2_k127_3269066_0 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 2.246e-196 623.0
HFD2_k127_3269066_1 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 597.0
HFD2_k127_3269066_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 510.0
HFD2_k127_3269066_3 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 447.0
HFD2_k127_3269066_4 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 402.0
HFD2_k127_3269066_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 322.0
HFD2_k127_3269066_6 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001328 297.0
HFD2_k127_3269066_7 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000007927 226.0
HFD2_k127_3269066_8 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000001925 133.0
HFD2_k127_3284654_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 494.0
HFD2_k127_3284654_1 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 466.0
HFD2_k127_3284654_2 abc transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006075 322.0
HFD2_k127_3284654_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 311.0
HFD2_k127_3284654_4 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 291.0
HFD2_k127_3284654_5 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003115 287.0
HFD2_k127_3284654_6 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001516 264.0
HFD2_k127_3284654_7 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000006074 252.0
HFD2_k127_3284654_8 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001337 233.0
HFD2_k127_3284654_9 - - - - 0.00000000000000000000000000000000000000000000000000000000009522 212.0
HFD2_k127_3377480_0 PFAM carboxyl transferase - - - 1.63e-221 718.0
HFD2_k127_3377480_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 6.776e-206 667.0
HFD2_k127_3377480_10 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 330.0
HFD2_k127_3377480_11 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 287.0
HFD2_k127_3377480_12 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007448 279.0
HFD2_k127_3377480_13 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001002 281.0
HFD2_k127_3377480_14 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.0000000000000000000000000000000000000000000000622 172.0
HFD2_k127_3377480_15 Biotin carboxyl carrier protein K02160 - - 0.00008771 51.0
HFD2_k127_3377480_2 Extracellular ligand-binding receptor K01999 - - 1.833e-197 622.0
HFD2_k127_3377480_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 573.0
HFD2_k127_3377480_4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009507 543.0
HFD2_k127_3377480_5 CoA binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 537.0
HFD2_k127_3377480_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 488.0
HFD2_k127_3377480_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 451.0
HFD2_k127_3377480_8 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 383.0
HFD2_k127_3377480_9 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 355.0
HFD2_k127_3417745_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 1.129e-261 828.0
HFD2_k127_3417745_1 PFAM isocitrate lyase and phosphorylmutase K01637 - 4.1.3.1 1.122e-222 698.0
HFD2_k127_3417745_10 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 472.0
HFD2_k127_3417745_11 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 408.0
HFD2_k127_3417745_12 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 388.0
HFD2_k127_3417745_13 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 345.0
HFD2_k127_3417745_14 Membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 337.0
HFD2_k127_3417745_15 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 293.0
HFD2_k127_3417745_16 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005614 282.0
HFD2_k127_3417745_17 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001933 244.0
HFD2_k127_3417745_18 - - - - 0.00000000000000000000000000000000000000000001449 177.0
HFD2_k127_3417745_19 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000001641 165.0
HFD2_k127_3417745_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 4.792e-222 702.0
HFD2_k127_3417745_20 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000000000251 162.0
HFD2_k127_3417745_21 integral membrane protein K02221 - - 0.0000000000000000000000000000000000008503 156.0
HFD2_k127_3417745_22 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000003427 130.0
HFD2_k127_3417745_23 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000001147 130.0
HFD2_k127_3417745_24 PFAM PTS system fructose subfamily IIA component K02821 - 2.7.1.194 0.00000000000000000000000000000001396 142.0
HFD2_k127_3417745_26 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000004045 124.0
HFD2_k127_3417745_27 Belongs to the UPF0235 family K09131 - - 0.000000000000001313 89.0
HFD2_k127_3417745_28 - - - - 0.00000000000003282 82.0
HFD2_k127_3417745_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.478e-219 689.0
HFD2_k127_3417745_4 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 1.221e-213 681.0
HFD2_k127_3417745_5 Rod shape-determining protein MreB K03569 - - 2.18e-201 634.0
HFD2_k127_3417745_6 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.032e-199 643.0
HFD2_k127_3417745_7 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 570.0
HFD2_k127_3417745_8 Major facilitator superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 560.0
HFD2_k127_3417745_9 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 496.0
HFD2_k127_3468131_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 1.899e-198 658.0
HFD2_k127_3468131_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 8.465e-196 619.0
HFD2_k127_3468131_10 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 448.0
HFD2_k127_3468131_11 Mg2 and Co2 transporter CorC K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 390.0
HFD2_k127_3468131_12 Membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 388.0
HFD2_k127_3468131_13 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 378.0
HFD2_k127_3468131_14 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 340.0
HFD2_k127_3468131_15 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 339.0
HFD2_k127_3468131_16 Ubiquinone biosynthesis hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 320.0
HFD2_k127_3468131_17 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 298.0
HFD2_k127_3468131_18 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001836 286.0
HFD2_k127_3468131_19 PFAM Glutamine amidotransferase class-I K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000739 286.0
HFD2_k127_3468131_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 593.0
HFD2_k127_3468131_20 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004412 271.0
HFD2_k127_3468131_21 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000000003882 200.0
HFD2_k127_3468131_22 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000003515 208.0
HFD2_k127_3468131_23 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615 4.4.1.5 0.00000000000000000000000000000000000000000000000000003071 203.0
HFD2_k127_3468131_24 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000005218 146.0
HFD2_k127_3468131_25 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.00000000000000000000000000000003021 130.0
HFD2_k127_3468131_3 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 585.0
HFD2_k127_3468131_4 SMART Tetratricopeptide domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 580.0
HFD2_k127_3468131_5 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 496.0
HFD2_k127_3468131_6 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 487.0
HFD2_k127_3468131_7 phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 472.0
HFD2_k127_3468131_8 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 459.0
HFD2_k127_3468131_9 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 443.0
HFD2_k127_3507345_0 B12 binding domain K00548 - 2.1.1.13 0.0 1684.0
HFD2_k127_3507345_1 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 1.113e-220 716.0
HFD2_k127_3507345_10 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000001968 224.0
HFD2_k127_3507345_11 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000001924 209.0
HFD2_k127_3507345_12 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000001357 187.0
HFD2_k127_3507345_13 Small membrane protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000003678 136.0
HFD2_k127_3507345_14 Belongs to the Smg family K03747 - - 0.000000000000000000000000000001208 139.0
HFD2_k127_3507345_2 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 2.918e-200 634.0
HFD2_k127_3507345_3 PFAM TrkA-N domain protein K03499 - - 1.46e-197 632.0
HFD2_k127_3507345_4 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 429.0
HFD2_k127_3507345_5 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 426.0
HFD2_k127_3507345_6 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009276 424.0
HFD2_k127_3507345_7 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 391.0
HFD2_k127_3507345_8 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 353.0
HFD2_k127_3507345_9 PFAM Peptidoglycan-binding LysM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 347.0
HFD2_k127_3578323_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1062.0
HFD2_k127_3578323_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 2.637e-267 852.0
HFD2_k127_3578323_2 Aminotransferase class I and II K00832 - 2.6.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 560.0
HFD2_k127_3578323_3 membrane - - - 0.0000000000008425 72.0
HFD2_k127_3585584_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005672 558.0
HFD2_k127_3585584_1 Belongs to the ABC transporter superfamily K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 422.0
HFD2_k127_3585584_2 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 404.0
HFD2_k127_3585584_3 Oligopeptide/dipeptide transporter, C-terminal region K02031,K15583,K15587 - 3.6.3.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 347.0
HFD2_k127_3585584_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000008629 138.0
HFD2_k127_362586_0 PFAM Tannase and feruloyl esterase - - - 2.673e-202 646.0
HFD2_k127_362586_1 Domain of unknown function (DUF4139) - - - 2.897e-196 622.0
HFD2_k127_362586_10 Lactoylglutathione lyase - - - 0.00000000000000000000000000000000000000000000000005197 182.0
HFD2_k127_362586_11 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000001825 130.0
HFD2_k127_362586_12 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000008646 123.0
HFD2_k127_362586_14 carbohydrate transport K11688,K17836 - 3.5.2.6 0.0000000003254 69.0
HFD2_k127_362586_15 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000001305 57.0
HFD2_k127_362586_2 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 572.0
HFD2_k127_362586_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 337.0
HFD2_k127_362586_4 Sir2 family K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 312.0
HFD2_k127_362586_5 Aldo/keto reductase family K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 310.0
HFD2_k127_362586_6 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005916 282.0
HFD2_k127_362586_7 Protein of unknown function (DUF2848) - - - 0.000000000000000000000000000000000000000000000000000000000000000001641 252.0
HFD2_k127_362586_8 MarR family - - - 0.000000000000000000000000000000000000000000000000000001309 196.0
HFD2_k127_362586_9 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000003043 186.0
HFD2_k127_3642530_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1251.0
HFD2_k127_3642530_1 extracellular solute-binding protein - - - 4.66e-288 914.0
HFD2_k127_3642530_10 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009339 384.0
HFD2_k127_3642530_11 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 346.0
HFD2_k127_3642530_12 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 323.0
HFD2_k127_3642530_13 squalene-associated FAD-dependent desaturase K21677 - 1.17.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 301.0
HFD2_k127_3642530_14 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000009586 132.0
HFD2_k127_3642530_15 - - - - 0.000000000009063 74.0
HFD2_k127_3642530_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 4.793e-218 681.0
HFD2_k127_3642530_3 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 611.0
HFD2_k127_3642530_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 539.0
HFD2_k127_3642530_5 peptidylprolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 543.0
HFD2_k127_3642530_6 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 496.0
HFD2_k127_3642530_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 473.0
HFD2_k127_3642530_8 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 410.0
HFD2_k127_3642530_9 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009789 400.0
HFD2_k127_3643644_0 ABC transporter transmembrane region K06147 - - 2.173e-247 781.0
HFD2_k127_3643644_1 AcyL-CoA dehydrogenase K06445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 524.0
HFD2_k127_3643644_2 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 523.0
HFD2_k127_3643644_3 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 317.0
HFD2_k127_3643644_4 Belongs to the peptidase S11 family K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001242 267.0
HFD2_k127_3643644_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000002257 227.0
HFD2_k127_3643644_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000006206 169.0
HFD2_k127_3650950_0 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 381.0
HFD2_k127_3650950_1 PFAM isochorismatase hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000002873 228.0
HFD2_k127_3650950_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000001008 190.0
HFD2_k127_3650950_3 Phenylacetic acid degradation protein PaaY K02617 - - 0.000000000000000000000000000000003878 131.0
HFD2_k127_3673266_0 4Fe-4S dicluster domain - - - 0.0 1223.0
HFD2_k127_3673266_1 Belongs to the IlvD Edd family - - - 4.51e-274 852.0
HFD2_k127_3673266_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 482.0
HFD2_k127_3673266_11 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 430.0
HFD2_k127_3673266_12 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008263 394.0
HFD2_k127_3673266_13 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008842 377.0
HFD2_k127_3673266_14 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009593 361.0
HFD2_k127_3673266_15 Thioredoxin-like K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 356.0
HFD2_k127_3673266_16 Histidine kinase K07641 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 363.0
HFD2_k127_3673266_17 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008153 326.0
HFD2_k127_3673266_18 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 320.0
HFD2_k127_3673266_19 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 327.0
HFD2_k127_3673266_2 Protein of unknown function, DUF255 K06888 - - 2.136e-252 796.0
HFD2_k127_3673266_20 Peptidase_C39 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 315.0
HFD2_k127_3673266_21 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 312.0
HFD2_k127_3673266_22 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 308.0
HFD2_k127_3673266_23 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 302.0
HFD2_k127_3673266_24 membrane transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 293.0
HFD2_k127_3673266_25 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 286.0
HFD2_k127_3673266_26 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001719 298.0
HFD2_k127_3673266_27 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003055 297.0
HFD2_k127_3673266_28 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003425 254.0
HFD2_k127_3673266_29 cytochrome - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009879 242.0
HFD2_k127_3673266_3 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 598.0
HFD2_k127_3673266_30 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000003214 228.0
HFD2_k127_3673266_31 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000002375 217.0
HFD2_k127_3673266_32 Bacterial protein of unknown function (DUF924) - - - 0.000000000000000000000000000000000000000000000000000002512 197.0
HFD2_k127_3673266_33 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000004352 195.0
HFD2_k127_3673266_34 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000008251 193.0
HFD2_k127_3673266_35 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000000000000000007402 175.0
HFD2_k127_3673266_36 macromolecule glycosylation - GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000001728 165.0
HFD2_k127_3673266_37 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000000003529 151.0
HFD2_k127_3673266_38 Cytochrome c K08738 - - 0.00000000000000000000000000002962 124.0
HFD2_k127_3673266_39 Cytochrome C' - - - 0.00000000000000000000008975 104.0
HFD2_k127_3673266_4 PFAM Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 546.0
HFD2_k127_3673266_40 - - - - 0.00000000000000001404 94.0
HFD2_k127_3673266_41 Histidine kinase - - - 0.0000000004892 72.0
HFD2_k127_3673266_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 516.0
HFD2_k127_3673266_6 III protein, CoA-transferase family K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 511.0
HFD2_k127_3673266_7 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007174 508.0
HFD2_k127_3673266_8 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 494.0
HFD2_k127_3673266_9 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007027 495.0
HFD2_k127_3714837_0 acyl-CoA dehydrogenase K06445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 511.0
HFD2_k127_3714837_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000001386 201.0
HFD2_k127_3740716_0 Flavin-binding monooxygenase-like - - - 1.354e-233 731.0
HFD2_k127_3740716_1 Acyclic terpene utilisation family protein AtuA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 539.0
HFD2_k127_3740716_2 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 522.0
HFD2_k127_3740716_3 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 331.0
HFD2_k127_3740716_4 KR domain K00076,K08081 - 1.1.1.159,1.1.1.206 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 324.0
HFD2_k127_3740716_5 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006673 268.0
HFD2_k127_3740716_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000283 228.0
HFD2_k127_3740716_7 - - - - 0.00000000000000000000000000006817 129.0
HFD2_k127_3740716_8 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.00000000000000001865 85.0
HFD2_k127_3758303_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 514.0
HFD2_k127_3758303_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000002321 218.0
HFD2_k127_3758303_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000002876 195.0
HFD2_k127_3758303_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000954 191.0
HFD2_k127_3758303_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000003123 183.0
HFD2_k127_3758303_5 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000002978 132.0
HFD2_k127_3758303_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000001377 86.0
HFD2_k127_3784807_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 547.0
HFD2_k127_3784807_1 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 481.0
HFD2_k127_3784807_2 NUDIX hydrolase - - - 0.00000000000000000000000000000000000003249 146.0
HFD2_k127_3784807_3 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000001257 145.0
HFD2_k127_3784807_4 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000004869 109.0
HFD2_k127_3807659_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1144.0
HFD2_k127_3807659_1 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002533 287.0
HFD2_k127_3807659_2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.000000000000000000000000000000000000000000000001021 183.0
HFD2_k127_3807659_3 Domain of unknown function (DUF4156) - - - 0.000000000000000003598 89.0
HFD2_k127_3807659_4 Unextendable partial coding region - - - 0.00000000001478 64.0
HFD2_k127_3807659_5 - - - - 0.00000000001826 76.0
HFD2_k127_3825973_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 385.0
HFD2_k127_3825973_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000002479 229.0
HFD2_k127_3860221_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.116e-235 741.0
HFD2_k127_3860221_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 481.0
HFD2_k127_3860221_10 Tetratricopeptide repeat - - - 0.0000000000000001641 79.0
HFD2_k127_3860221_2 Peptidase M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 436.0
HFD2_k127_3860221_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 413.0
HFD2_k127_3860221_4 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 400.0
HFD2_k127_3860221_5 abc transporter K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 310.0
HFD2_k127_3860221_6 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001452 288.0
HFD2_k127_3860221_7 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001245 244.0
HFD2_k127_3860221_8 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000005151 201.0
HFD2_k127_3860221_9 iron ion homeostasis - - - 0.00000000000000000000000000000000000000000004029 174.0
HFD2_k127_3874199_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01907 - 6.2.1.1,6.2.1.16 2.947e-261 822.0
HFD2_k127_3874199_1 PFAM ABC transporter K02471 - - 2.258e-205 653.0
HFD2_k127_3874199_10 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000000000000000000004714 196.0
HFD2_k127_3874199_11 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000001178 153.0
HFD2_k127_3874199_12 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000001471 139.0
HFD2_k127_3874199_13 Bacterial regulatory proteins, tetR family K16137 - - 0.000000000000000000000000000001427 124.0
HFD2_k127_3874199_14 cobalamin (vitamin B12) biosynthesis CbiX protein K03795 - 4.99.1.3 0.00000000000000000000000000004806 126.0
HFD2_k127_3874199_2 ABC transporter K10004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 403.0
HFD2_k127_3874199_3 Bacterial periplasmic substrate-binding proteins K02030,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 375.0
HFD2_k127_3874199_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 346.0
HFD2_k127_3874199_5 With GltJLPS and GadC for glutamate and GltJLP, DctA and DcuAB for aspartate is involved in the transport of glutamate and aspartate K10002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 327.0
HFD2_k127_3874199_6 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 333.0
HFD2_k127_3874199_7 ABC transporter permease K02029,K10003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 324.0
HFD2_k127_3874199_8 2-phospho-L-lactate transferase K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 290.0
HFD2_k127_3874199_9 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000008843 227.0
HFD2_k127_387744_0 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 346.0
HFD2_k127_387744_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000189 286.0
HFD2_k127_387744_2 IPP transferase K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000002269 201.0
HFD2_k127_387744_3 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000005614 78.0
HFD2_k127_3890236_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 4.069e-287 897.0
HFD2_k127_3890236_1 glycolate oxidase iron-sulfur subunit K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001012 281.0
HFD2_k127_3890236_2 SMART PAS domain containing protein - - - 0.0000000000000000000000000000005417 141.0
HFD2_k127_3917114_0 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 487.0
HFD2_k127_3917114_1 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 378.0
HFD2_k127_3917114_2 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000001422 246.0
HFD2_k127_3917114_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000004783 224.0
HFD2_k127_3917114_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000003397 191.0
HFD2_k127_3917114_5 Protein of unknown function (DUF1428) - - - 0.000000000000000000000000000000000000000000000005917 174.0
HFD2_k127_3917114_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000002159 179.0
HFD2_k127_3917114_7 Belongs to the UPF0311 family - - - 0.0000000000000000000000000000000000000000003854 162.0
HFD2_k127_3917114_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000329 130.0
HFD2_k127_3917114_9 PFAM Activator of Hsp90 ATPase - - - 0.000000000000001308 89.0
HFD2_k127_3928391_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1182.0
HFD2_k127_3928391_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 464.0
HFD2_k127_3928391_10 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003327 268.0
HFD2_k127_3928391_11 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007172 260.0
HFD2_k127_3928391_12 PFAM Metal-dependent phosphohydrolase, HD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001325 271.0
HFD2_k127_3928391_13 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000306 249.0
HFD2_k127_3928391_14 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000000000000000000000000000000000000000003232 248.0
HFD2_k127_3928391_15 cyclic nucleotide binding K01420 - - 0.00000000000000000000000000000000000000000000000000000000000001658 224.0
HFD2_k127_3928391_16 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.0000000000000000000000000000000000000000000000000000000000007836 216.0
HFD2_k127_3928391_17 sensor diguanylate cyclase phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000001382 228.0
HFD2_k127_3928391_18 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000417 192.0
HFD2_k127_3928391_19 - - - - 0.00000000000000000000000000000000000000000000006286 181.0
HFD2_k127_3928391_2 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 416.0
HFD2_k127_3928391_20 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000002375 108.0
HFD2_k127_3928391_3 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 389.0
HFD2_k127_3928391_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 381.0
HFD2_k127_3928391_5 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 381.0
HFD2_k127_3928391_6 Sensor protein, DUF3365, HAMP and PAS domain-containing, heme-binding K05962 - 2.7.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 372.0
HFD2_k127_3928391_7 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 374.0
HFD2_k127_3928391_8 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 365.0
HFD2_k127_3928391_9 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 331.0
HFD2_k127_3941243_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 336.0
HFD2_k127_3941243_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000001579 228.0
HFD2_k127_3941243_2 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000779 221.0
HFD2_k127_3941243_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000846 68.0
HFD2_k127_3982752_0 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 2.654e-244 773.0
HFD2_k127_3982752_1 pfkB family carbohydrate kinase K00852,K00856 - 2.7.1.15,2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 443.0
HFD2_k127_3982752_2 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006224 264.0
HFD2_k127_3982752_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000576 191.0
HFD2_k127_3982752_4 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000102 189.0
HFD2_k127_3982752_5 Histidine triad (Hit) protein K02503 - - 0.00000000000000000000000000000000000000000000184 172.0
HFD2_k127_3982752_6 - - - - 0.000000000000000000000000000000000000000000009332 171.0
HFD2_k127_3982752_7 Protein of unknown function (DUF3426) - - - 0.0000000000000000000000000000000000000206 160.0
HFD2_k127_3982752_8 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.00000000000000000000000000000000006036 134.0
HFD2_k127_3982752_9 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.0000000000000000000000003802 106.0
HFD2_k127_4024994_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008628 574.0
HFD2_k127_4024994_1 Protein of unknown function (DUF3141) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 500.0
HFD2_k127_4024994_2 PFAM phosphate acetyl butaryl transferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 472.0
HFD2_k127_4024994_3 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000001267 79.0
HFD2_k127_4158104_0 succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 5.756e-231 726.0
HFD2_k127_4158104_1 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 553.0
HFD2_k127_4158104_10 LemA family K03744 - - 0.00000000000000000000000000000000000000001358 155.0
HFD2_k127_4158104_11 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000003059 144.0
HFD2_k127_4158104_12 LemA family K03744 - - 0.000000000000000000000003714 117.0
HFD2_k127_4158104_13 Ring hydroxylating subunit beta family protein 1 - - - 0.000000000000000000000007575 117.0
HFD2_k127_4158104_2 FAD linked oxidase domain protein K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 447.0
HFD2_k127_4158104_3 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 407.0
HFD2_k127_4158104_4 ATP ADP translocase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 391.0
HFD2_k127_4158104_5 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 326.0
HFD2_k127_4158104_6 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 337.0
HFD2_k127_4158104_7 LysR family transcription regulator protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004885 265.0
HFD2_k127_4158104_9 Pfam Cupin - - - 0.00000000000000000000000000000000000000000000000000006434 192.0
HFD2_k127_4237733_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 4.714e-221 691.0
HFD2_k127_4237733_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.115e-206 648.0
HFD2_k127_4237733_10 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000256 250.0
HFD2_k127_4237733_11 colicin V production K03558 - - 0.00000000000000000000000002898 114.0
HFD2_k127_4237733_12 PFAM Sporulation domain protein K03749 - - 0.00000000000000000003745 98.0
HFD2_k127_4237733_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 558.0
HFD2_k127_4237733_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000998 539.0
HFD2_k127_4237733_4 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 461.0
HFD2_k127_4237733_5 LysM domain K08086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 452.0
HFD2_k127_4237733_6 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 435.0
HFD2_k127_4237733_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 365.0
HFD2_k127_4237733_8 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 344.0
HFD2_k127_4237733_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 302.0
HFD2_k127_4287479_0 Formate dehydrogenase subunit alpha - - - 0.0 1213.0
HFD2_k127_4287479_1 General secretory system II protein E domain protein K02454,K02652,K12276 - - 0.0 1120.0
HFD2_k127_4287479_10 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 486.0
HFD2_k127_4287479_11 PFAM formyl transferase domain protein K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 427.0
HFD2_k127_4287479_12 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 407.0
HFD2_k127_4287479_13 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 374.0
HFD2_k127_4287479_14 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 355.0
HFD2_k127_4287479_15 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 351.0
HFD2_k127_4287479_16 (FHA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 305.0
HFD2_k127_4287479_17 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001157 282.0
HFD2_k127_4287479_18 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008746 269.0
HFD2_k127_4287479_19 membrane protein, terc - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005186 245.0
HFD2_k127_4287479_2 Belongs to the TPP enzyme family K01577 - 4.1.1.8 0.0 1003.0
HFD2_k127_4287479_20 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000008664 162.0
HFD2_k127_4287479_21 Tfp pilus assembly protein, major pilin PilA K02650 - - 0.0000000000000000000000000000000000001402 151.0
HFD2_k127_4287479_22 Phosphopantetheine attachment site - - - 0.000000000000000000000000000005626 126.0
HFD2_k127_4287479_23 Belongs to the universal stress protein A family - - - 0.0000000000000000004688 92.0
HFD2_k127_4287479_3 serine threonine protein kinase K12132 - 2.7.11.1 8.4e-322 1022.0
HFD2_k127_4287479_4 CHASE2 K01768 - 4.6.1.1 2.891e-288 903.0
HFD2_k127_4287479_5 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 7.183e-284 880.0
HFD2_k127_4287479_6 Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00122 - 1.17.1.9 1.057e-264 834.0
HFD2_k127_4287479_7 Tripartite tricarboxylate transporter TctA family K07793 - - 4.641e-245 766.0
HFD2_k127_4287479_8 metal-dependent phosphohydrolase HD sub domain - - - 1.621e-236 743.0
HFD2_k127_4287479_9 CoA-transferase family III K07749,K14471,K14472 - 2.8.3.16,2.8.3.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 588.0
HFD2_k127_4290145_0 AcrB/AcrD/AcrF family - - - 0.0 1264.0
HFD2_k127_4290145_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1197.0
HFD2_k127_4290145_10 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 452.0
HFD2_k127_4290145_11 VWA domain containing CoxE-like protein K07161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 447.0
HFD2_k127_4290145_12 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 427.0
HFD2_k127_4290145_13 histidine kinase HAMP region domain protein K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 373.0
HFD2_k127_4290145_14 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 363.0
HFD2_k127_4290145_15 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 365.0
HFD2_k127_4290145_16 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 361.0
HFD2_k127_4290145_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 350.0
HFD2_k127_4290145_18 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 342.0
HFD2_k127_4290145_19 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 320.0
HFD2_k127_4290145_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.716e-290 906.0
HFD2_k127_4290145_20 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 308.0
HFD2_k127_4290145_21 Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001489 276.0
HFD2_k127_4290145_22 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007375 291.0
HFD2_k127_4290145_23 molybdenum cofactor K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001053 272.0
HFD2_k127_4290145_24 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001608 273.0
HFD2_k127_4290145_25 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002786 274.0
HFD2_k127_4290145_26 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000008911 267.0
HFD2_k127_4290145_27 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000003337 244.0
HFD2_k127_4290145_28 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000000000000006608 230.0
HFD2_k127_4290145_29 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000000005561 200.0
HFD2_k127_4290145_3 NADH ubiquinone plastoquinone (Complex I) - - - 4.07e-270 862.0
HFD2_k127_4290145_30 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000006927 199.0
HFD2_k127_4290145_31 carbon monoxide dehydrogenase K09386 - - 0.00000000000000000000000000000000000000000000000001209 187.0
HFD2_k127_4290145_32 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000000405 145.0
HFD2_k127_4290145_33 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000106 118.0
HFD2_k127_4290145_34 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000884 113.0
HFD2_k127_4290145_35 CHASE2 K01768 - 4.6.1.1 0.0000001248 61.0
HFD2_k127_4290145_4 NADH Ubiquinone plastoquinone (Complex I) K12141 - - 1.792e-237 753.0
HFD2_k127_4290145_5 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 581.0
HFD2_k127_4290145_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 554.0
HFD2_k127_4290145_7 General function prediction only K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 552.0
HFD2_k127_4290145_8 With GlrK is part of a two-component signal transduction system regulating glmY K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 534.0
HFD2_k127_4290145_9 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 454.0
HFD2_k127_4369562_0 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 2.178e-257 803.0
HFD2_k127_4369562_1 Tripartite tricarboxylate transporter TctA family K07793 - - 8.174e-218 687.0
HFD2_k127_4369562_10 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000001806 197.0
HFD2_k127_4369562_11 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000002444 185.0
HFD2_k127_4369562_12 - - - - 0.0000000000000000000000000000000000000000000000003669 181.0
HFD2_k127_4369562_13 TraB family K00657,K09973 - 2.3.1.57 0.0000000000000000000000000000000000000000000000003695 187.0
HFD2_k127_4369562_14 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000000000000000000000000002725 168.0
HFD2_k127_4369562_15 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000000001036 141.0
HFD2_k127_4369562_16 DsrE/DsrF-like family K09004 - - 0.00000000000000000000001214 106.0
HFD2_k127_4369562_17 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000001153 100.0
HFD2_k127_4369562_18 - - - - 0.00000000000001271 74.0
HFD2_k127_4369562_2 PUA-like domain K00958 - 2.7.7.4 9.369e-199 629.0
HFD2_k127_4369562_3 Conserved hypothetical protein 698 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 510.0
HFD2_k127_4369562_4 reductase, alpha subunit K00394 - 1.8.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 487.0
HFD2_k127_4369562_5 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 449.0
HFD2_k127_4369562_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 404.0
HFD2_k127_4369562_7 PFAM conserved K07795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 331.0
HFD2_k127_4369562_8 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007052 301.0
HFD2_k127_4369562_9 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000289 239.0
HFD2_k127_4425127_0 Penicillin amidase K01434 - 3.5.1.11 5.493e-285 899.0
HFD2_k127_4425127_1 PHB de-polymerase C-terminus K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 520.0
HFD2_k127_4425127_2 NAD(P)H-binding - - - 0.00000000000000000000000427 105.0
HFD2_k127_4430264_0 GDP-mannose 4,6 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 589.0
HFD2_k127_4430264_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 542.0
HFD2_k127_4430264_10 TIGRFAM methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000000000000000002766 218.0
HFD2_k127_4430264_11 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000003223 168.0
HFD2_k127_4430264_12 Belongs to the NAD(P)-dependent epimerase dehydratase family - - - 0.00000000000000000000000000000000000000005524 160.0
HFD2_k127_4430264_13 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K02021,K11085 - - 0.0000000000000000000000000000000002247 133.0
HFD2_k127_4430264_14 Methyltransferase domain - - - 0.0000000000000000000001054 99.0
HFD2_k127_4430264_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 464.0
HFD2_k127_4430264_3 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 454.0
HFD2_k127_4430264_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 321.0
HFD2_k127_4430264_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001463 275.0
HFD2_k127_4430264_6 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000002382 251.0
HFD2_k127_4430264_7 glycosyl transferase family 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004278 256.0
HFD2_k127_4430264_8 Glycosyl transferase, family 2 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000000000000000000000000000000000000000000000007721 254.0
HFD2_k127_4430264_9 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000005415 227.0
HFD2_k127_4437006_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 5.897e-259 803.0
HFD2_k127_4437006_1 CHASE2 K01768 - 4.6.1.1 9.189e-198 643.0
HFD2_k127_4437006_10 membrane-bound metal-dependent K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 325.0
HFD2_k127_4437006_11 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 314.0
HFD2_k127_4437006_12 N-Acetylmuramoyl-L-alanine amidase K12287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 322.0
HFD2_k127_4437006_13 Lipid A Biosynthesis K02517,K12974 - 2.3.1.241,2.3.1.242 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 296.0
HFD2_k127_4437006_14 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 304.0
HFD2_k127_4437006_15 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 299.0
HFD2_k127_4437006_16 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002526 308.0
HFD2_k127_4437006_17 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000002189 273.0
HFD2_k127_4437006_18 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000000000000000000000000002853 235.0
HFD2_k127_4437006_19 membrane K08972 - - 0.0000000000000000000000000000000006744 147.0
HFD2_k127_4437006_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008383 593.0
HFD2_k127_4437006_20 OmpA-like transmembrane domain - - - 0.00000000000000000002849 97.0
HFD2_k127_4437006_21 Sh3 type 3 domain protein - - - 0.000000001029 70.0
HFD2_k127_4437006_22 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000001188 64.0
HFD2_k127_4437006_3 serine-type endopeptidase activity K04772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 516.0
HFD2_k127_4437006_4 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 460.0
HFD2_k127_4437006_5 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 464.0
HFD2_k127_4437006_6 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 414.0
HFD2_k127_4437006_7 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 396.0
HFD2_k127_4437006_8 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007105 375.0
HFD2_k127_4437006_9 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 342.0
HFD2_k127_4482926_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1380.0
HFD2_k127_4482926_1 Peptidase family M3 K01414 - 3.4.24.70 1.196e-315 977.0
HFD2_k127_4482926_10 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 469.0
HFD2_k127_4482926_11 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 384.0
HFD2_k127_4482926_12 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 337.0
HFD2_k127_4482926_13 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 339.0
HFD2_k127_4482926_14 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 302.0
HFD2_k127_4482926_15 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002545 254.0
HFD2_k127_4482926_16 RNA methyltransferase K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000004217 236.0
HFD2_k127_4482926_17 Bacterial protein of unknown function (DUF898) - - - 0.0000000000000000000000000000000000000000000000000000000000006875 224.0
HFD2_k127_4482926_18 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000000000000001452 169.0
HFD2_k127_4482926_19 AraC-like ligand binding domain - - - 0.00000000000000000000000000004337 130.0
HFD2_k127_4482926_2 Dehydratase family K13875 - 4.2.1.25 9.092e-262 812.0
HFD2_k127_4482926_20 Domain of unknown function (DUF4124) - - - 0.000000000000000000000000003767 128.0
HFD2_k127_4482926_21 - - - - 0.0000000000000000002923 92.0
HFD2_k127_4482926_3 Belongs to the malate synthase family K01638 - 2.3.3.9 5.169e-247 771.0
HFD2_k127_4482926_4 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 5.046e-232 728.0
HFD2_k127_4482926_5 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 2.078e-227 713.0
HFD2_k127_4482926_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 627.0
HFD2_k127_4482926_7 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 586.0
HFD2_k127_4482926_8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 530.0
HFD2_k127_4482926_9 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 505.0
HFD2_k127_4489008_0 PFAM acyl-CoA dehydrogenase domain protein K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 549.0
HFD2_k127_4489008_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 480.0
HFD2_k127_4489008_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 406.0
HFD2_k127_4489008_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000005646 243.0
HFD2_k127_44891_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 8.006e-237 741.0
HFD2_k127_44891_1 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 499.0
HFD2_k127_44891_10 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 400.0
HFD2_k127_44891_11 A G-specific K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 357.0
HFD2_k127_44891_12 Platelet-activating factor acetylhydrolase, isoform II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 336.0
HFD2_k127_44891_13 Putative methyltransferase K03439 - 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000048 281.0
HFD2_k127_44891_14 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000002853 280.0
HFD2_k127_44891_15 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002439 270.0
HFD2_k127_44891_16 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000003968 244.0
HFD2_k127_44891_17 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000009928 228.0
HFD2_k127_44891_18 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000000000000144 205.0
HFD2_k127_44891_19 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000001262 112.0
HFD2_k127_44891_2 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 486.0
HFD2_k127_44891_20 ThiS family K03154 - - 0.00000000000000000236 89.0
HFD2_k127_44891_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 480.0
HFD2_k127_44891_4 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 482.0
HFD2_k127_44891_5 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008144 468.0
HFD2_k127_44891_6 N-terminal TM domain of oligopeptide transport permease C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 453.0
HFD2_k127_44891_7 AsmA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 436.0
HFD2_k127_44891_8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 436.0
HFD2_k127_44891_9 5'-nucleotidase K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 402.0
HFD2_k127_4491359_0 FAD dependent oxidoreductase - - - 1.488e-208 654.0
HFD2_k127_4491359_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000004145 130.0
HFD2_k127_4494817_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 9.538e-244 783.0
HFD2_k127_4494817_1 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 389.0
HFD2_k127_4494817_10 PFAM CBS domain containing protein - - - 0.00000000000000000000001658 113.0
HFD2_k127_4494817_11 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 0.0008146 43.0
HFD2_k127_4494817_2 (ABC) transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 353.0
HFD2_k127_4494817_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008916 350.0
HFD2_k127_4494817_4 Formate/nitrite transporter K02598,K21993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 336.0
HFD2_k127_4494817_5 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008205 268.0
HFD2_k127_4494817_6 phosphoribosyltransferase K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002378 258.0
HFD2_k127_4494817_7 ribosomal large subunit export from nucleus - - - 0.000000000000000000000000000000000000000000000000000000000004149 217.0
HFD2_k127_4494817_8 Adenylylsulfate kinase K00860 - 2.7.1.25 0.0000000000000000000000000000000000001064 149.0
HFD2_k127_4494817_9 dksA traR - - - 0.0000000000000000000000000000002278 127.0
HFD2_k127_4498867_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 8.963e-221 698.0
HFD2_k127_4498867_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 604.0
HFD2_k127_4498867_10 Nicotinamidase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 319.0
HFD2_k127_4498867_11 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008604 309.0
HFD2_k127_4498867_12 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 297.0
HFD2_k127_4498867_13 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007225 281.0
HFD2_k127_4498867_14 COG0642 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003958 275.0
HFD2_k127_4498867_15 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000006087 227.0
HFD2_k127_4498867_16 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000003845 220.0
HFD2_k127_4498867_17 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000006261 219.0
HFD2_k127_4498867_18 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000000000002308 205.0
HFD2_k127_4498867_19 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000001286 188.0
HFD2_k127_4498867_2 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 532.0
HFD2_k127_4498867_20 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000001328 173.0
HFD2_k127_4498867_21 Thioesterase superfamily K10806 - - 0.000000000000000000000000000000000000000000003877 168.0
HFD2_k127_4498867_22 Tautomerase enzyme - - - 0.0000000000000000000000000000000000000008412 162.0
HFD2_k127_4498867_23 COGs COG4446 conserved - - - 0.000000000000000000000000000000000000002928 151.0
HFD2_k127_4498867_24 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000001065 155.0
HFD2_k127_4498867_25 PFAM FecR protein K03832 - - 0.000000000000000000000002735 118.0
HFD2_k127_4498867_26 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00219,K01069 - 1.3.1.34,3.1.2.6 0.0000000000000000000001331 99.0
HFD2_k127_4498867_27 Tetratricopeptide repeat - - - 0.0000000000000000005903 100.0
HFD2_k127_4498867_28 sensor histidine kinase response regulator - - - 0.00000000000000001357 90.0
HFD2_k127_4498867_3 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 450.0
HFD2_k127_4498867_30 Protein of unknown function (DUF465) - - - 0.000000000009702 70.0
HFD2_k127_4498867_4 PFAM short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 417.0
HFD2_k127_4498867_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 422.0
HFD2_k127_4498867_6 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 402.0
HFD2_k127_4498867_7 Alpha/beta hydrolase family K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 391.0
HFD2_k127_4498867_8 7TM diverse intracellular signalling - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 400.0
HFD2_k127_4498867_9 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 326.0
HFD2_k127_4506465_0 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 386.0
HFD2_k127_4506465_1 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005671 310.0
HFD2_k127_4506465_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006709 285.0
HFD2_k127_4506465_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001427 259.0
HFD2_k127_4506465_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000001514 241.0
HFD2_k127_4506465_5 FecR protein - - - 0.000000000000000000000000000000000001337 149.0
HFD2_k127_4506465_6 FecR protein - - - 0.0000000000000000000000000000000002085 145.0
HFD2_k127_4506465_7 - - - - 0.000000000000000000001441 94.0
HFD2_k127_4506465_8 Domain of unknown function (DUF4124) - - - 0.00002189 53.0
HFD2_k127_4511012_0 Peptidase family M48 - - - 6.827e-255 799.0
HFD2_k127_4511012_1 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 389.0
HFD2_k127_4511012_2 Phospholipase, patatin family K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 352.0
HFD2_k127_4511012_3 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000003192 182.0
HFD2_k127_4511012_4 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000001573 177.0
HFD2_k127_4511012_5 lyase activity K01387,K03301 - 3.4.24.3 0.0000000000000000000000000000000000000000000001776 191.0
HFD2_k127_4511012_6 Domain of unknown function (DUF202) K00389 - - 0.0000000000000000000000000000000000000001811 153.0
HFD2_k127_4534103_0 pfam abc - - - 3.901e-243 763.0
HFD2_k127_4534103_1 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 402.0
HFD2_k127_4534103_2 PFAM Cold-shock protein, DNA-binding K03704 - - 0.000000000000000000000000000138 116.0
HFD2_k127_4534103_3 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000005001 74.0
HFD2_k127_4534103_4 helix_turn_helix, Lux Regulon K07684,K07693 - - 0.000000006329 63.0
HFD2_k127_455735_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.414e-225 704.0
HFD2_k127_455735_1 oxidase, subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009503 563.0
HFD2_k127_455735_2 Carbon-nitrogen hydrolase K01501 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 409.0
HFD2_k127_455735_3 cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 380.0
HFD2_k127_455735_4 PD-(D/E)XK nuclease superfamily K01144 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 297.0
HFD2_k127_455735_5 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003862 261.0
HFD2_k127_455735_6 Glyoxalase bleomycin resistance - - - 0.000000000000000000000000000000000000000000000000000007542 192.0
HFD2_k127_455735_7 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000000000000000000007481 188.0
HFD2_k127_455735_8 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000006054 185.0
HFD2_k127_455735_9 PFAM Transglycosylase associated protein - - - 0.000000005175 60.0
HFD2_k127_4583864_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1049.0
HFD2_k127_4583864_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1039.0
HFD2_k127_4583864_10 RNA cap guanine-N2 methyltransferase K07320 - 2.1.1.298 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009697 290.0
HFD2_k127_4583864_11 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004381 268.0
HFD2_k127_4583864_12 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000000000003195 231.0
HFD2_k127_4583864_13 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000002604 228.0
HFD2_k127_4583864_14 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000376 215.0
HFD2_k127_4583864_15 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 0.000000000000000000000000000000000000000000000000000000002945 201.0
HFD2_k127_4583864_16 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000002169 185.0
HFD2_k127_4583864_17 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000001499 129.0
HFD2_k127_4583864_18 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.000000000000000000000000000003054 132.0
HFD2_k127_4583864_19 - - - - 0.000000000002353 69.0
HFD2_k127_4583864_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 2.502e-244 772.0
HFD2_k127_4583864_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 9.175e-216 683.0
HFD2_k127_4583864_4 PFAM Aminotransferase class I and II K14267 - 2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 524.0
HFD2_k127_4583864_5 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 503.0
HFD2_k127_4583864_6 twitching motility protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 453.0
HFD2_k127_4583864_7 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 421.0
HFD2_k127_4583864_8 Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 402.0
HFD2_k127_4583864_9 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 339.0
HFD2_k127_4630366_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 617.0
HFD2_k127_4630366_1 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 486.0
HFD2_k127_4630366_10 Belongs to the methyltransferase superfamily K07444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008611 274.0
HFD2_k127_4630366_11 VanZ like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000456 256.0
HFD2_k127_4630366_12 Alpha beta K07018 - - 0.000000000000000000000000000000000000000000000000000000000000007768 240.0
HFD2_k127_4630366_13 Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000001921 213.0
HFD2_k127_4630366_14 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000001746 181.0
HFD2_k127_4630366_15 Ferredoxin - - - 0.00000000000000000000000000000000000000000000001336 172.0
HFD2_k127_4630366_16 PFAM Sterol-binding domain protein K03690 - - 0.0000000000000000000000000000405 124.0
HFD2_k127_4630366_17 Domain of unknown function (DUF4345) - - - 0.0000000000000000000003083 100.0
HFD2_k127_4630366_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 480.0
HFD2_k127_4630366_3 PFAM ABC transporter related K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 437.0
HFD2_k127_4630366_4 Signal transduction histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 398.0
HFD2_k127_4630366_5 Pfam Binding-protein-dependent transport systems inner membrane component K02054,K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 371.0
HFD2_k127_4630366_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 369.0
HFD2_k127_4630366_7 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 336.0
HFD2_k127_4630366_8 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 341.0
HFD2_k127_4630366_9 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007584 273.0
HFD2_k127_4641285_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 462.0
HFD2_k127_4641285_1 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 462.0
HFD2_k127_4641285_2 AMP-binding enzyme C-terminal domain K00666,K20034 - 6.2.1.44 0.00000000000000000000000000000000000000000014 170.0
HFD2_k127_4641285_3 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.0000000000000000000000000002253 128.0
HFD2_k127_4649652_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 501.0
HFD2_k127_4649652_1 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 445.0
HFD2_k127_4649652_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 439.0
HFD2_k127_4649652_3 Peptidase family M23 K08259 - 3.4.24.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 330.0
HFD2_k127_4649652_4 - - - - 0.000006884 49.0
HFD2_k127_4649652_5 Protein of unknown function (DUF721) - - - 0.00004539 53.0
HFD2_k127_4671839_0 glycolate oxidase subunit GlcD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 539.0
HFD2_k127_4671839_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007872 318.0
HFD2_k127_4671839_2 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 301.0
HFD2_k127_4671839_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000577 286.0
HFD2_k127_4671839_4 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002419 270.0
HFD2_k127_4671839_5 ABC-type branched-chain amino acid transport K01999 - - 0.0000000000000000000000000001009 132.0
HFD2_k127_4671839_6 Thioesterase superfamily - - - 0.00000000000000000000000006292 125.0
HFD2_k127_4671839_7 Methyltransferase domain - - - 0.0000000000000000156 87.0
HFD2_k127_4671839_8 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000001874 66.0
HFD2_k127_4671839_9 Mycolic acid cyclopropane synthetase - - - 0.0003166 44.0
HFD2_k127_4676451_0 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 333.0
HFD2_k127_4676451_1 GIY-YIG type nucleases (URI domain) K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000004722 184.0
HFD2_k127_4676451_2 arginine transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000369 172.0
HFD2_k127_4676451_3 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000004793 71.0
HFD2_k127_4743724_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0 1172.0
HFD2_k127_4743724_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 9.019e-308 952.0
HFD2_k127_4743724_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 424.0
HFD2_k127_4743724_11 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 374.0
HFD2_k127_4743724_12 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 366.0
HFD2_k127_4743724_13 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 336.0
HFD2_k127_4743724_14 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000000000000000000000000001348 221.0
HFD2_k127_4743724_15 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000008433 196.0
HFD2_k127_4743724_16 ATP synthase B/B' CF(0) K02109 - - 0.000000000000000000000000000000000000000000000001225 178.0
HFD2_k127_4743724_17 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000002459 164.0
HFD2_k127_4743724_18 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000000008148 143.0
HFD2_k127_4743724_19 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000004387 114.0
HFD2_k127_4743724_2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 6.8e-291 904.0
HFD2_k127_4743724_20 ATP synthase I chain K02116 - - 0.0000000000000000000103 96.0
HFD2_k127_4743724_21 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000003598 73.0
HFD2_k127_4743724_22 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000001765 61.0
HFD2_k127_4743724_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.561e-199 632.0
HFD2_k127_4743724_4 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 597.0
HFD2_k127_4743724_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 563.0
HFD2_k127_4743724_6 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 502.0
HFD2_k127_4743724_7 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 489.0
HFD2_k127_4743724_8 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 454.0
HFD2_k127_4743724_9 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 452.0
HFD2_k127_4771565_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.14e-233 727.0
HFD2_k127_4771565_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 541.0
HFD2_k127_4771565_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000004414 209.0
HFD2_k127_4771565_11 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000001142 203.0
HFD2_k127_4771565_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000001706 191.0
HFD2_k127_4771565_13 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000001082 190.0
HFD2_k127_4771565_14 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000000000002802 183.0
HFD2_k127_4771565_15 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000008571 164.0
HFD2_k127_4771565_16 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000002364 149.0
HFD2_k127_4771565_17 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000001007 143.0
HFD2_k127_4771565_18 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000029 134.0
HFD2_k127_4771565_19 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000003369 91.0
HFD2_k127_4771565_2 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 365.0
HFD2_k127_4771565_20 Ribosomal protein L30 K02907 - - 0.0000000000000000008532 95.0
HFD2_k127_4771565_21 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000003433 69.0
HFD2_k127_4771565_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 342.0
HFD2_k127_4771565_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 297.0
HFD2_k127_4771565_5 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 285.0
HFD2_k127_4771565_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005868 256.0
HFD2_k127_4771565_7 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001399 240.0
HFD2_k127_4771565_8 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000000000001549 226.0
HFD2_k127_4771565_9 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000009532 224.0
HFD2_k127_4781430_0 Participates in both transcription termination and antitermination K02600 - - 9.037e-222 702.0
HFD2_k127_4781430_1 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 1.613e-207 651.0
HFD2_k127_4781430_10 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008268 276.0
HFD2_k127_4781430_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001344 263.0
HFD2_k127_4781430_12 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000000000000004512 212.0
HFD2_k127_4781430_13 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000005285 174.0
HFD2_k127_4781430_14 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000002274 168.0
HFD2_k127_4781430_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.129e-196 627.0
HFD2_k127_4781430_3 D-amino acid dehydrogenase K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 458.0
HFD2_k127_4781430_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 359.0
HFD2_k127_4781430_5 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 352.0
HFD2_k127_4781430_6 SMART phosphoesterase PHP domain protein K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 332.0
HFD2_k127_4781430_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 322.0
HFD2_k127_4781430_8 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 308.0
HFD2_k127_4781430_9 Belongs to the SUA5 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002086 281.0
HFD2_k127_4809480_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.623e-230 750.0
HFD2_k127_4809480_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 3.553e-224 718.0
HFD2_k127_4809480_10 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 319.0
HFD2_k127_4809480_11 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 317.0
HFD2_k127_4809480_12 SMP-30/Gluconolaconase/LRE-like region K13874,K14274 - 3.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 317.0
HFD2_k127_4809480_13 carboxylic acid catabolic process K01856 - 5.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 315.0
HFD2_k127_4809480_14 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008281 283.0
HFD2_k127_4809480_15 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001798 261.0
HFD2_k127_4809480_16 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000001826 241.0
HFD2_k127_4809480_17 Methyl-transferase K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000005879 202.0
HFD2_k127_4809480_18 LemA family - - - 0.000000000000000000000000000000000000000000000004342 189.0
HFD2_k127_4809480_19 - - - - 0.00004683 51.0
HFD2_k127_4809480_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 7.453e-211 669.0
HFD2_k127_4809480_3 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 561.0
HFD2_k127_4809480_4 L-lactate dehydrogenase K00101,K00104 - 1.1.2.3,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 549.0
HFD2_k127_4809480_5 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 421.0
HFD2_k127_4809480_6 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 380.0
HFD2_k127_4809480_7 mechanosensitive ion channel K03442 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 344.0
HFD2_k127_4809480_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 345.0
HFD2_k127_4809480_9 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 332.0
HFD2_k127_4828638_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1005.0
HFD2_k127_4828638_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 541.0
HFD2_k127_4828638_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001739 261.0
HFD2_k127_4828638_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000001157 191.0
HFD2_k127_4828638_4 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000001277 195.0
HFD2_k127_4828638_5 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000002448 89.0
HFD2_k127_4874178_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 411.0
HFD2_k127_4874178_1 oxidoreductase K04090 - 1.2.7.8 0.000000000000000000000000000000000000000000000004692 174.0
HFD2_k127_4941027_0 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 3.678e-286 883.0
HFD2_k127_4941027_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.787e-265 828.0
HFD2_k127_4941027_10 PFAM fumarylacetoacetate (FAA) hydrolase K18336 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 403.0
HFD2_k127_4941027_11 Transcriptional regulator K21703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 340.0
HFD2_k127_4941027_12 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 329.0
HFD2_k127_4941027_13 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 316.0
HFD2_k127_4941027_14 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 297.0
HFD2_k127_4941027_15 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007971 273.0
HFD2_k127_4941027_16 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000207 284.0
HFD2_k127_4941027_17 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006678 246.0
HFD2_k127_4941027_18 PFAM Ribulose bisphosphate carboxylase, small chain K01602 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000002477 197.0
HFD2_k127_4941027_19 RDD family - - - 0.00000000000000000002954 105.0
HFD2_k127_4941027_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.023e-223 704.0
HFD2_k127_4941027_20 Belongs to the IlvD Edd family K13875 - 4.2.1.25 0.000000000000000002659 96.0
HFD2_k127_4941027_21 Ankyrin repeat - - - 0.0000008746 61.0
HFD2_k127_4941027_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 1.27e-203 642.0
HFD2_k127_4941027_4 catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 563.0
HFD2_k127_4941027_5 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 543.0
HFD2_k127_4941027_6 TIGRFAM amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 521.0
HFD2_k127_4941027_7 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K01086,K03841 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 486.0
HFD2_k127_4941027_8 Phosphoribulokinase K00855 - 2.7.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 484.0
HFD2_k127_4941027_9 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 440.0
HFD2_k127_4954365_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1253.0
HFD2_k127_4954365_1 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 563.0
HFD2_k127_4954365_10 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007032 305.0
HFD2_k127_4954365_11 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002786 293.0
HFD2_k127_4954365_12 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000009614 271.0
HFD2_k127_4954365_13 Dioxygenases related to 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000009536 229.0
HFD2_k127_4954365_14 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.00000000000000000000000000000000000000000000000000000002376 216.0
HFD2_k127_4954365_15 Glutathione S-transferase K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000006012 167.0
HFD2_k127_4954365_16 Acyl-CoA synthetase (NDP forming) - - - 0.0000000000000000001678 99.0
HFD2_k127_4954365_17 EamA-like transporter family - - - 0.0000000002486 71.0
HFD2_k127_4954365_2 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 552.0
HFD2_k127_4954365_3 Outer membrane efflux protein K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 545.0
HFD2_k127_4954365_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 531.0
HFD2_k127_4954365_5 maleylacetate reductase K00217 - 1.3.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 456.0
HFD2_k127_4954365_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 404.0
HFD2_k127_4954365_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 417.0
HFD2_k127_4954365_8 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 332.0
HFD2_k127_4954365_9 response regulator receiver K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 299.0
HFD2_k127_4983844_0 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1440.0
HFD2_k127_4983844_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 361.0
HFD2_k127_4983844_2 Phospholipase A1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008703 312.0
HFD2_k127_4983844_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000001158 166.0
HFD2_k127_5129347_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 3.105e-205 645.0
HFD2_k127_5129347_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 567.0
HFD2_k127_5129347_2 Belongs to the peptidase S1C family K04691,K04772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009592 477.0
HFD2_k127_5129347_3 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 373.0
HFD2_k127_5129347_4 Belongs to the GST superfamily K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 326.0
HFD2_k127_5129347_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001388 254.0
HFD2_k127_5129347_6 Cytochrome C1 family K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003326 267.0
HFD2_k127_5129347_7 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000001975 217.0
HFD2_k127_5129347_8 stringent starvation protein b K03600 - - 0.000000000000000000000000000000000000000006036 158.0
HFD2_k127_514192_0 Histidine Phosphotransfer domain K02487,K06596 - - 2.729e-245 786.0
HFD2_k127_514192_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 446.0
HFD2_k127_514192_2 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 423.0
HFD2_k127_514192_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 342.0
HFD2_k127_514192_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 302.0
HFD2_k127_514192_5 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000005601 206.0
HFD2_k127_52415_0 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 395.0
HFD2_k127_52415_1 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 387.0
HFD2_k127_52415_2 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 355.0
HFD2_k127_52415_3 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 363.0
HFD2_k127_52415_4 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 348.0
HFD2_k127_52415_5 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 297.0
HFD2_k127_52415_6 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001754 292.0
HFD2_k127_52415_7 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.00000001124 67.0
HFD2_k127_5266735_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 392.0
HFD2_k127_5266735_1 Bacterial periplasmic substrate-binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001319 280.0
HFD2_k127_5271600_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 466.0
HFD2_k127_5271600_1 fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001263 255.0
HFD2_k127_5271600_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000005459 123.0
HFD2_k127_5271600_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.000002515 51.0
HFD2_k127_5289270_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008261 610.0
HFD2_k127_5289270_1 Protein of unknown function (DUF993) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006888 537.0
HFD2_k127_5289270_2 Mandelate Racemase Muconate Lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 477.0
HFD2_k127_5289270_3 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001005 298.0
HFD2_k127_5289270_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000001619 229.0
HFD2_k127_5289270_5 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000004683 210.0
HFD2_k127_5289270_6 NMT1/THI5 like - - - 0.0000000000000000000000000000000000000009155 151.0
HFD2_k127_5296797_0 PFAM transposase, mutator K07493 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008962 330.0
HFD2_k127_5309082_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.969e-289 897.0
HFD2_k127_5309082_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 3.57e-227 712.0
HFD2_k127_5309082_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007821 395.0
HFD2_k127_5309082_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 385.0
HFD2_k127_5309082_12 oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 380.0
HFD2_k127_5309082_13 Sigma-70 factor, region 1.2 K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 356.0
HFD2_k127_5309082_14 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005492 357.0
HFD2_k127_5309082_15 Belongs to the aldehyde dehydrogenase family K00141 - 1.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 366.0
HFD2_k127_5309082_16 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 323.0
HFD2_k127_5309082_17 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 328.0
HFD2_k127_5309082_18 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 305.0
HFD2_k127_5309082_19 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007371 278.0
HFD2_k127_5309082_2 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 569.0
HFD2_k127_5309082_20 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006926 261.0
HFD2_k127_5309082_21 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000005192 250.0
HFD2_k127_5309082_22 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000008509 237.0
HFD2_k127_5309082_23 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000003689 241.0
HFD2_k127_5309082_24 Involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000002322 237.0
HFD2_k127_5309082_25 oxidase assembly K02258 - - 0.00000000000000000000000000000000000000000000000000000000000000004918 230.0
HFD2_k127_5309082_26 Transcriptional regulator, AraC family - - - 0.0000000000000000000000000000000000000000000000000000000000000002158 232.0
HFD2_k127_5309082_27 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000007568 223.0
HFD2_k127_5309082_28 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000002869 223.0
HFD2_k127_5309082_29 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000000000000000000000001826 186.0
HFD2_k127_5309082_3 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 550.0
HFD2_k127_5309082_30 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000003553 172.0
HFD2_k127_5309082_31 SURF1 family - - - 0.000000000000000000000000000000000000000000006975 170.0
HFD2_k127_5309082_32 signal sequence binding - - - 0.0000000000000000000000000000000000000000001229 165.0
HFD2_k127_5309082_33 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000001435 126.0
HFD2_k127_5309082_34 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.00000000000004463 76.0
HFD2_k127_5309082_35 Protein of unknown function (DUF2909) - - - 0.000000000356 65.0
HFD2_k127_5309082_36 Pfam:DUF1602 - - - 0.000000006949 61.0
HFD2_k127_5309082_37 - - - - 0.0003504 43.0
HFD2_k127_5309082_38 Integral membrane protein (DUF2244) - - - 0.0005921 45.0
HFD2_k127_5309082_39 Protein of unknown function (DUF2970) - - - 0.0008198 50.0
HFD2_k127_5309082_4 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 523.0
HFD2_k127_5309082_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 512.0
HFD2_k127_5309082_6 SMART Tetratricopeptide domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007387 491.0
HFD2_k127_5309082_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 466.0
HFD2_k127_5309082_8 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 458.0
HFD2_k127_5309082_9 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 405.0
HFD2_k127_5322770_0 Amidohydrolase K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 484.0
HFD2_k127_5322770_1 Divalent cation transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 467.0
HFD2_k127_5322770_2 COG3119 Arylsulfatase A and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 401.0
HFD2_k127_5322770_3 ERAP1-like C-terminal domain K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 392.0
HFD2_k127_5322770_4 CBS domain - - - 0.00000000000000000000000000000000000000000996 170.0
HFD2_k127_5349577_0 Periplasmic binding protein K01999 - - 3.387e-195 615.0
HFD2_k127_5349577_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652,K12673 - 2.2.1.6,2.5.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 615.0
HFD2_k127_5349577_10 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 347.0
HFD2_k127_5349577_11 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 314.0
HFD2_k127_5349577_12 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002577 257.0
HFD2_k127_5349577_13 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007321 251.0
HFD2_k127_5349577_14 Domain of unknown function (DUF1932) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002951 245.0
HFD2_k127_5349577_15 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000001363 199.0
HFD2_k127_5349577_16 4,5-dihydroxyphthalate decarboxylase - - - 0.00000000000000000000000000000000000000000006779 176.0
HFD2_k127_5349577_17 domain, Protein K00703,K07082 - 2.4.1.21 0.00000000000000000002708 96.0
HFD2_k127_5349577_18 4,5-dihydroxyphthalate decarboxylase - - - 0.00000000000172 68.0
HFD2_k127_5349577_2 CoA binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 629.0
HFD2_k127_5349577_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 599.0
HFD2_k127_5349577_4 PFAM MmgE PrpD family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 582.0
HFD2_k127_5349577_5 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 471.0
HFD2_k127_5349577_6 LysR substrate binding domain K13794,K19338 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 462.0
HFD2_k127_5349577_7 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 387.0
HFD2_k127_5349577_8 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 366.0
HFD2_k127_5349577_9 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 363.0
HFD2_k127_5369389_0 TonB-dependent Receptor Plug Domain K02014 - - 1.323e-197 644.0
HFD2_k127_5369389_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 593.0
HFD2_k127_5369389_10 Acetyltransferase (GNAT) domain K03828 - - 0.00000000000000000000000001778 115.0
HFD2_k127_5369389_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 417.0
HFD2_k127_5369389_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 322.0
HFD2_k127_5369389_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 316.0
HFD2_k127_5369389_5 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 295.0
HFD2_k127_5369389_6 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001697 273.0
HFD2_k127_5369389_7 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0000000000000000000000000000000000000000000006629 168.0
HFD2_k127_5369389_8 cytochrome - - - 0.000000000000000000000000000000000000006685 152.0
HFD2_k127_5369389_9 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - 0.00000000000000000000000000000000000005047 145.0
HFD2_k127_5374380_0 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006654 584.0
HFD2_k127_5374380_1 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008696 570.0
HFD2_k127_5374380_2 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 316.0
HFD2_k127_5381977_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0 1057.0
HFD2_k127_5381977_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 555.0
HFD2_k127_5381977_10 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000001673 221.0
HFD2_k127_5381977_11 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000709 213.0
HFD2_k127_5381977_12 Solute carrier family 35 - - - 0.0000000000000000000000000000000000000000000000006481 186.0
HFD2_k127_5381977_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000001316 179.0
HFD2_k127_5381977_14 FAD binding domain K00480 - 1.14.13.1 0.00000000000000000000000000000000000003554 146.0
HFD2_k127_5381977_15 Voltage-dependent anion channel K03304 - - 0.0000000000000000000000000000000000004772 157.0
HFD2_k127_5381977_16 Protein of unknown function (DUF4240) - - - 0.0000000000000000000000001852 115.0
HFD2_k127_5381977_17 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000004209 110.0
HFD2_k127_5381977_2 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 531.0
HFD2_k127_5381977_3 Dehydrogenase K00031,K00052,K07246 GO:0006082,GO:0006575,GO:0006732,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016053,GO:0019297,GO:0019298,GO:0019752,GO:0032787,GO:0042398,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 1.1.1.42,1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 433.0
HFD2_k127_5381977_4 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009694 401.0
HFD2_k127_5381977_5 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002427 373.0
HFD2_k127_5381977_6 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004927 350.0
HFD2_k127_5381977_7 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002047 294.0
HFD2_k127_5381977_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005654 274.0
HFD2_k127_5381977_9 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006408 265.0
HFD2_k127_5388044_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1652.0
HFD2_k127_5388044_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K12276 - - 6.465e-249 780.0
HFD2_k127_5388044_10 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001987 248.0
HFD2_k127_5388044_11 Domain of unknown function DUF108 K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000111 240.0
HFD2_k127_5388044_12 type IV pilus modification protein PilV K10927 - - 0.00000000000000000000000000000000000000000001586 173.0
HFD2_k127_5388044_13 prepilin-type N-terminal cleavage methylation K12285 - - 0.000000000000000000000000000000000000002286 158.0
HFD2_k127_5388044_14 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000000000000000002423 149.0
HFD2_k127_5388044_15 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K12280 - - 0.0000000000000000000000000000000008825 143.0
HFD2_k127_5388044_16 Tetratricopeptide repeat K12284 - - 0.0000000000000000000000002462 119.0
HFD2_k127_5388044_17 type II secretion system protein K K12286 - - 0.0000000000000000006075 99.0
HFD2_k127_5388044_18 - K12281 - - 0.00000000000004909 79.0
HFD2_k127_5388044_19 Tfp pilus assembly protein FimT K10926 - - 0.0000000000002072 77.0
HFD2_k127_5388044_2 type II and III secretion system protein K02453,K12282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 518.0
HFD2_k127_5388044_20 general secretion pathway protein K02456 - - 0.0000000000002572 79.0
HFD2_k127_5388044_21 Prokaryotic N-terminal methylation motif K10924 - - 0.0000000006695 65.0
HFD2_k127_5388044_23 O-Antigen ligase K18814 - - 0.000004823 59.0
HFD2_k127_5388044_3 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 482.0
HFD2_k127_5388044_4 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 438.0
HFD2_k127_5388044_5 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 426.0
HFD2_k127_5388044_6 AAA domain K02450,K12283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 353.0
HFD2_k127_5388044_7 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 314.0
HFD2_k127_5388044_8 Pilus assembly protein K12279 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001282 270.0
HFD2_k127_5388044_9 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002291 267.0
HFD2_k127_5404823_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 2.001e-203 643.0
HFD2_k127_5404823_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 411.0
HFD2_k127_5404823_2 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 402.0
HFD2_k127_5404823_3 PFAM class II aldolase adducin family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 296.0
HFD2_k127_5404823_4 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000000000000008042 196.0
HFD2_k127_5404823_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000008211 197.0
HFD2_k127_5404823_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000523 173.0
HFD2_k127_5404823_7 LTXXQ motif family protein - - - 0.0000000000000000000000000000005845 128.0
HFD2_k127_5422844_0 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007459 585.0
HFD2_k127_5422844_1 DEAD DEAH box helicase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 503.0
HFD2_k127_5422844_10 - - - - 0.0000000000000000000001998 104.0
HFD2_k127_5422844_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 419.0
HFD2_k127_5422844_3 PFAM Short-chain dehydrogenase reductase SDR K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 340.0
HFD2_k127_5422844_4 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000668 261.0
HFD2_k127_5422844_5 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000001958 233.0
HFD2_k127_5422844_6 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000765 209.0
HFD2_k127_5422844_7 PFAM transport-associated - - - 0.0000000000000000000000000000000000000000000000000000008482 205.0
HFD2_k127_5422844_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000483 141.0
HFD2_k127_5422844_9 Tetratricopeptide repeat - - - 0.000000000000000000000000009787 117.0
HFD2_k127_5429221_0 Sulfatase - - - 3.022e-224 712.0
HFD2_k127_5429221_1 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 512.0
HFD2_k127_5429221_10 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000001393 198.0
HFD2_k127_5429221_11 PBP superfamily domain - - - 0.0000000000000000000000000000000000000000000000001006 190.0
HFD2_k127_5429221_12 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000000000000000007202 155.0
HFD2_k127_5429221_13 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000007313 160.0
HFD2_k127_5429221_14 Uncharacterized ACR, COG1993 - - - 0.0000000000000000000000000000000000007555 141.0
HFD2_k127_5429221_15 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000001956 113.0
HFD2_k127_5429221_16 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000000000001022 108.0
HFD2_k127_5429221_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 457.0
HFD2_k127_5429221_3 Bacterial extracellular solute-binding protein K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 415.0
HFD2_k127_5429221_4 Superoxide dismutase K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 366.0
HFD2_k127_5429221_5 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 297.0
HFD2_k127_5429221_6 ABC transporter K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002734 284.0
HFD2_k127_5429221_7 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009674 286.0
HFD2_k127_5429221_8 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000001016 235.0
HFD2_k127_5429221_9 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000000000000000000000000000000000000000000000005625 230.0
HFD2_k127_5470096_0 GXGXG motif K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2336.0
HFD2_k127_5470096_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1272.0
HFD2_k127_5470096_10 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 475.0
HFD2_k127_5470096_11 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 409.0
HFD2_k127_5470096_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 319.0
HFD2_k127_5470096_13 MgtC family K07507 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001756 274.0
HFD2_k127_5470096_14 Pilus assembly protein PilO K02664 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000479 254.0
HFD2_k127_5470096_15 Shikimate kinase K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000000000209 226.0
HFD2_k127_5470096_16 Domain of unknown function (DUF4396) - - - 0.0000000000000000000000000000000000000000000000000000000000008967 214.0
HFD2_k127_5470096_17 fimbrial biogenesis protein PilN K02663 - - 0.00000000000000000000000000000000000000000000000000000001551 210.0
HFD2_k127_5470096_18 PFAM Blue (type 1) copper domain - - - 0.0000000000000000000000000000000000000000000000756 173.0
HFD2_k127_5470096_19 helix_turn_helix, mercury resistance K19591 - - 0.0000000000000000000000000000000000000000000004084 171.0
HFD2_k127_5470096_2 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 8.131e-295 925.0
HFD2_k127_5470096_20 pilus assembly protein PilP K02665 - - 0.000000000000000000000000000000000000000000003763 169.0
HFD2_k127_5470096_21 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000001451 164.0
HFD2_k127_5470096_22 Belongs to the frataxin K06202 - - 0.00000000000000000000000000000007401 133.0
HFD2_k127_5470096_23 Heavy-metal-associated domain K07213 - - 0.0000000000000001753 83.0
HFD2_k127_5470096_24 Copper binding periplasmic protein CusF - - - 0.000000000000007102 77.0
HFD2_k127_5470096_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 5.171e-284 884.0
HFD2_k127_5470096_4 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 5.312e-276 869.0
HFD2_k127_5470096_5 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 1.111e-241 758.0
HFD2_k127_5470096_6 type II and III secretion system protein K02666 - - 9.039e-240 765.0
HFD2_k127_5470096_7 Oxidoreductase - - - 4.064e-211 671.0
HFD2_k127_5470096_8 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 531.0
HFD2_k127_5470096_9 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 501.0
HFD2_k127_5473925_0 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 8.218e-293 906.0
HFD2_k127_5473925_1 twitching motility protein K02670 - - 8.594e-204 638.0
HFD2_k127_5473925_10 - - - - 0.0000000000000000000002164 97.0
HFD2_k127_5473925_11 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000000000008118 97.0
HFD2_k127_5473925_2 twitching motility protein K02669 - - 8.414e-196 617.0
HFD2_k127_5473925_3 Belongs to the methyltransferase superfamily K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 444.0
HFD2_k127_5473925_4 PFAM ABC transporter related K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 415.0
HFD2_k127_5473925_5 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 339.0
HFD2_k127_5473925_6 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 291.0
HFD2_k127_5473925_7 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004487 258.0
HFD2_k127_5473925_8 Uncharacterised protein family (UPF0093) K08973 - - 0.00000000000000000000000000000000000000000000000000000000001001 209.0
HFD2_k127_5578051_0 dead deah K03724 - - 6.187e-316 986.0
HFD2_k127_5625671_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 6.012e-307 948.0
HFD2_k127_5625671_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 538.0
HFD2_k127_5625671_10 MOSC N-terminal beta barrel domain K07140 - - 0.000000000000000000000000000000000000000002102 166.0
HFD2_k127_5625671_11 Protein of unknown function (DUF2946) - - - 0.0000000000000000000000000000000000002343 148.0
HFD2_k127_5625671_12 Ribonuclease K01167 - 3.1.27.3 0.00000000000000000000000000001121 128.0
HFD2_k127_5625671_13 (barnase) inhibitor - - - 0.000000000000000000001626 99.0
HFD2_k127_5625671_2 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 430.0
HFD2_k127_5625671_3 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 314.0
HFD2_k127_5625671_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004207 254.0
HFD2_k127_5625671_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000001193 222.0
HFD2_k127_5625671_6 dehydratase - - - 0.000000000000000000000000000000000000000000000000000003929 198.0
HFD2_k127_5625671_7 2-phosphosulfolactate phosphatase activity K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.000000000000000000000000000000000000000000000000000007648 205.0
HFD2_k127_5625671_8 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000003954 198.0
HFD2_k127_5625671_9 NUDIX domain K08310 - 3.6.1.67 0.000000000000000000000000000000000000000000000007251 177.0
HFD2_k127_565714_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 460.0
HFD2_k127_565714_1 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 299.0
HFD2_k127_565714_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000009259 258.0
HFD2_k127_565714_3 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000000101 211.0
HFD2_k127_565714_4 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000008342 124.0
HFD2_k127_565714_5 response to heat K07090 - - 0.00000000000000000000000004726 117.0
HFD2_k127_5703477_0 Malic enzyme K00029 - 1.1.1.40 0.0 1055.0
HFD2_k127_5703477_1 PFAM Peptidase M48 K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 501.0
HFD2_k127_5703477_10 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000175 100.0
HFD2_k127_5703477_11 - - - - 0.000000000000000001291 102.0
HFD2_k127_5703477_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 449.0
HFD2_k127_5703477_3 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 418.0
HFD2_k127_5703477_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 331.0
HFD2_k127_5703477_5 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 284.0
HFD2_k127_5703477_6 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000001608 216.0
HFD2_k127_5703477_7 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000007216 164.0
HFD2_k127_5703477_8 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381,K00392 - 1.8.1.2,1.8.7.1 0.00000000000000000000000000000000000000000002284 164.0
HFD2_k127_5703477_9 - - - - 0.00000000000000000000006747 111.0
HFD2_k127_5708773_0 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 8.164e-223 698.0
HFD2_k127_5708773_1 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 612.0
HFD2_k127_5708773_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 549.0
HFD2_k127_5708773_3 - - - - 0.000000000000000000000000000000000000000000000000000001307 213.0
HFD2_k127_5708773_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000268 188.0
HFD2_k127_5708773_5 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000001532 175.0
HFD2_k127_5708773_6 carboxylic ester hydrolase activity - - - 0.000000000001218 77.0
HFD2_k127_5802597_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1013.0
HFD2_k127_5802597_1 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 1.584e-285 888.0
HFD2_k127_5802597_10 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000000000000002449 190.0
HFD2_k127_5802597_11 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000007928 188.0
HFD2_k127_5802597_12 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.000000000000000000000000000000000000000000001288 184.0
HFD2_k127_5802597_13 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000011 168.0
HFD2_k127_5802597_14 FeS assembly protein IscX - - - 0.00000000000000000000000002564 115.0
HFD2_k127_5802597_15 - - - - 0.00001001 53.0
HFD2_k127_5802597_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K11745,K11747 - - 1.595e-232 734.0
HFD2_k127_5802597_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 1.018e-204 651.0
HFD2_k127_5802597_4 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003467 357.0
HFD2_k127_5802597_5 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 343.0
HFD2_k127_5802597_6 serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 293.0
HFD2_k127_5802597_7 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003538 242.0
HFD2_k127_5802597_8 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.0000000000000000000000000000000000000000000000000000000000000002822 224.0
HFD2_k127_5802597_9 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000005002 203.0
HFD2_k127_5830884_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 515.0
HFD2_k127_5830884_1 hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 509.0
HFD2_k127_5830884_2 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 471.0
HFD2_k127_5830884_3 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 422.0
HFD2_k127_5830884_4 esterase K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 287.0
HFD2_k127_5830884_5 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000002516 243.0
HFD2_k127_5830884_6 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 0.0000000000000000000001169 98.0
HFD2_k127_5853805_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 573.0
HFD2_k127_5853805_1 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 351.0
HFD2_k127_5853805_2 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000001827 104.0
HFD2_k127_5853805_3 membrane - - - 0.0000000001596 70.0
HFD2_k127_587306_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 325.0
HFD2_k127_587306_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005304 303.0
HFD2_k127_587306_2 - - - - 0.000000000000000000000000001989 124.0
HFD2_k127_5883461_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 8.033e-228 717.0
HFD2_k127_5883461_1 TonB dependent receptor K02014 - - 2.403e-208 671.0
HFD2_k127_5883461_10 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000001704 113.0
HFD2_k127_5883461_11 O-Antigen ligase - - - 0.00000000000000000000009211 111.0
HFD2_k127_5883461_12 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000007429 86.0
HFD2_k127_5883461_13 - - - - 0.0000000009289 61.0
HFD2_k127_5883461_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 528.0
HFD2_k127_5883461_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 364.0
HFD2_k127_5883461_4 Glycosyltransferase family 9 (heptosyltransferase) K02849 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 341.0
HFD2_k127_5883461_5 Glycosyltransferase family 25 (LPS biosynthesis protein) K07270 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 293.0
HFD2_k127_5883461_6 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005258 227.0
HFD2_k127_5883461_7 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000001422 222.0
HFD2_k127_5883461_8 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000000000003309 192.0
HFD2_k127_5883461_9 cell division protein - - - 0.0000000000000000000000000000000000000000002334 168.0
HFD2_k127_593186_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001323 238.0
HFD2_k127_593186_1 4Fe-4S dicluster domain K00338,K02573,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000003518 147.0
HFD2_k127_593186_2 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.0000000000000000004367 98.0
HFD2_k127_61583_0 cytochrome - - - 9.842e-223 720.0
HFD2_k127_61583_1 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 593.0
HFD2_k127_61583_2 radical SAM protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 545.0
HFD2_k127_61583_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 284.0
HFD2_k127_61583_4 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002285 273.0
HFD2_k127_6185287_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01577,K01652,K03852 - 2.2.1.6,2.3.3.15,4.1.1.8 2.058e-238 743.0
HFD2_k127_6185287_1 Periplasmic binding protein LacI transcriptional regulator K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 354.0
HFD2_k127_6185287_2 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 319.0
HFD2_k127_6185287_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002001 265.0
HFD2_k127_6187977_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 2.739e-215 708.0
HFD2_k127_6187977_1 PFAM extracellular solute-binding protein, family 5 K02035 - - 1.574e-194 621.0
HFD2_k127_6187977_10 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 387.0
HFD2_k127_6187977_11 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001129 264.0
HFD2_k127_6187977_12 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000008481 253.0
HFD2_k127_6187977_13 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000006671 241.0
HFD2_k127_6187977_14 Protein of unknown function (DUF3833) - - - 0.0000000000000000000000000000000000000000000000000000000000000000289 232.0
HFD2_k127_6187977_15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000089 163.0
HFD2_k127_6187977_16 SnoaL-like domain K01822 - 5.3.3.1 0.0000000000000000000000000000000000000000315 167.0
HFD2_k127_6187977_17 PFAM Sporulation domain protein - - - 0.000000000000000000000000001053 121.0
HFD2_k127_6187977_18 GDSL-like Lipase/Acylhydrolase - - - 0.000000001476 61.0
HFD2_k127_6187977_2 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 594.0
HFD2_k127_6187977_3 PFAM extracellular solute-binding protein family 1 K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 535.0
HFD2_k127_6187977_4 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006323 524.0
HFD2_k127_6187977_5 transport system, periplasmic component K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 436.0
HFD2_k127_6187977_6 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816,K10111,K10112 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009797 443.0
HFD2_k127_6187977_7 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 423.0
HFD2_k127_6187977_8 PFAM binding-protein-dependent transport systems inner membrane component K05814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 424.0
HFD2_k127_6187977_9 probably responsible for the translocation of the substrate across the membrane K02026,K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 420.0
HFD2_k127_6211006_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 609.0
HFD2_k127_6211006_1 PFAM Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000821 512.0
HFD2_k127_6211006_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 399.0
HFD2_k127_6211006_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 327.0
HFD2_k127_6211006_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001149 281.0
HFD2_k127_6211006_5 squalene-associated FAD-dependent desaturase - - - 0.00000000000000000003331 93.0
HFD2_k127_6211006_6 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000007315 63.0
HFD2_k127_6214829_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 475.0
HFD2_k127_6214829_1 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 473.0
HFD2_k127_6214829_10 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000002948 262.0
HFD2_k127_6214829_11 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000165 252.0
HFD2_k127_6214829_12 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000003039 213.0
HFD2_k127_6214829_13 SWI complex, BAF60b domains - - - 0.0000000000000000000000000000000001501 136.0
HFD2_k127_6214829_14 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000001593 85.0
HFD2_k127_6214829_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 471.0
HFD2_k127_6214829_3 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 402.0
HFD2_k127_6214829_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 391.0
HFD2_k127_6214829_5 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 369.0
HFD2_k127_6214829_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 363.0
HFD2_k127_6214829_7 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 383.0
HFD2_k127_6214829_8 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 331.0
HFD2_k127_6214829_9 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001295 267.0
HFD2_k127_6216487_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 4.142e-251 803.0
HFD2_k127_6216487_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 3.004e-218 717.0
HFD2_k127_6216487_10 Glutathione S-Transferase K00799 GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000003664 252.0
HFD2_k127_6216487_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000008936 222.0
HFD2_k127_6216487_12 CoA-binding protein K06929 - - 0.0000000000000000000000000000000000000000000000000000000000008768 236.0
HFD2_k127_6216487_13 NIPSNAP - - - 0.0000000000000000000000000000000000000000000005666 169.0
HFD2_k127_6216487_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000003078 166.0
HFD2_k127_6216487_15 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000001714 142.0
HFD2_k127_6216487_16 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000003393 143.0
HFD2_k127_6216487_17 Bacterial extracellular solute-binding proteins, family 3 K02030 - - 0.000000000000000000000000005333 116.0
HFD2_k127_6216487_19 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000005094 74.0
HFD2_k127_6216487_2 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 8.044e-218 693.0
HFD2_k127_6216487_20 - - - - 0.000000001766 68.0
HFD2_k127_6216487_21 Putative aminopeptidase - - - 0.00000003504 59.0
HFD2_k127_6216487_3 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.595e-206 649.0
HFD2_k127_6216487_4 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 448.0
HFD2_k127_6216487_5 Zinc-binding dehydrogenase K12957,K13953,K19961 - 1.1.1.1,1.1.1.258 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 383.0
HFD2_k127_6216487_6 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 348.0
HFD2_k127_6216487_7 Carboxylesterase family K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 325.0
HFD2_k127_6216487_8 Macrocin-O-methyltransferase (TylF) K05303,K15996 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0030769,GO:0032259,GO:0044237,GO:0044249 2.1.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 296.0
HFD2_k127_6216487_9 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002745 263.0
HFD2_k127_6265891_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 1.237e-274 852.0
HFD2_k127_6265891_1 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 1.378e-241 768.0
HFD2_k127_6265891_2 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 520.0
HFD2_k127_6265891_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005497 500.0
HFD2_k127_6265891_4 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 451.0
HFD2_k127_6265891_5 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 298.0
HFD2_k127_6265891_6 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008172 269.0
HFD2_k127_6265891_7 Pfam Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000006726 213.0
HFD2_k127_6265891_8 Thioesterase superfamily - - - 0.00000000000005977 74.0
HFD2_k127_6265891_9 Protein of unknown function (DUF1289) K06938 - - 0.0000004396 63.0
HFD2_k127_6307621_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 3.565e-306 961.0
HFD2_k127_6307621_1 Bacterial extracellular solute-binding protein K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 577.0
HFD2_k127_6307621_10 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001132 250.0
HFD2_k127_6307621_11 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002839 239.0
HFD2_k127_6307621_12 Universal stress protein UspA - - - 0.000000000000000000000000000000000000000000000000000000000004833 228.0
HFD2_k127_6307621_13 - - - - 0.0000000000000000000000000000001301 141.0
HFD2_k127_6307621_14 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000000417 91.0
HFD2_k127_6307621_15 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000009089 63.0
HFD2_k127_6307621_2 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 548.0
HFD2_k127_6307621_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 540.0
HFD2_k127_6307621_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 517.0
HFD2_k127_6307621_5 COG3839 ABC-type sugar transport systems, ATPase components K05816 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 443.0
HFD2_k127_6307621_6 ABC-type sugar transport system, permease component K05815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 426.0
HFD2_k127_6307621_7 ABC-type sugar K02025,K05814,K10118,K17242,K17245 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 413.0
HFD2_k127_6307621_8 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 412.0
HFD2_k127_6307621_9 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 330.0
HFD2_k127_6314484_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 5.564e-196 618.0
HFD2_k127_6314484_1 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K00480,K22270 - 1.14.13.1,1.14.13.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 386.0
HFD2_k127_6314484_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001194 284.0
HFD2_k127_6314484_3 COG1943 Transposase and inactivated derivatives K07491 - - 0.0000000000000000000000000000000000000000000000000000000000003681 235.0
HFD2_k127_6314484_4 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000001254 160.0
HFD2_k127_6314484_5 lactoylglutathione lyase activity K08234 - - 0.0000000000000000000000000000000009642 138.0
HFD2_k127_6324690_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1197.0
HFD2_k127_6324690_1 in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence K06020 GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 7.551e-216 683.0
HFD2_k127_6324690_10 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008945 274.0
HFD2_k127_6324690_11 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000006821 242.0
HFD2_k127_6324690_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000000000000000000000000000000001043 222.0
HFD2_k127_6324690_13 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000000000000000000000000000000002234 207.0
HFD2_k127_6324690_14 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000008325 195.0
HFD2_k127_6324690_15 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000001236 184.0
HFD2_k127_6324690_16 PFAM MaoC domain protein dehydratase - - - 0.0000000000000000000000007279 106.0
HFD2_k127_6324690_17 - - - - 0.000000000000005674 78.0
HFD2_k127_6324690_18 Belongs to the ompA family K03286 - - 0.00001573 58.0
HFD2_k127_6324690_2 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 574.0
HFD2_k127_6324690_3 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 520.0
HFD2_k127_6324690_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 525.0
HFD2_k127_6324690_5 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 435.0
HFD2_k127_6324690_6 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 391.0
HFD2_k127_6324690_7 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 325.0
HFD2_k127_6324690_8 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 306.0
HFD2_k127_6324690_9 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000081 289.0
HFD2_k127_6393342_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 5.207e-200 650.0
HFD2_k127_6393342_1 Single-stranded-DNA-specific exonuclease K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 610.0
HFD2_k127_6393342_10 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000001363 236.0
HFD2_k127_6393342_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000002109 229.0
HFD2_k127_6393342_12 - - - - 0.0000000000000000000000000000000000000000000000000000000187 199.0
HFD2_k127_6393342_13 ZIP Zinc transporter K07238 - - 0.00000000000000000000000000000000000000000000000000001473 199.0
HFD2_k127_6393342_14 protein conserved in bacteria K09984 - - 0.000000000000000000000000000000000000000000000000000103 187.0
HFD2_k127_6393342_15 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000001379 183.0
HFD2_k127_6393342_16 Glycine zipper 2TM domain - - - 0.000000000000000000000000000000496 131.0
HFD2_k127_6393342_17 KTSC domain - - - 0.000000000004356 68.0
HFD2_k127_6393342_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 535.0
HFD2_k127_6393342_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 518.0
HFD2_k127_6393342_4 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 446.0
HFD2_k127_6393342_5 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 381.0
HFD2_k127_6393342_6 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 331.0
HFD2_k127_6393342_7 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008122 269.0
HFD2_k127_6393342_8 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003714 264.0
HFD2_k127_6393342_9 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001165 244.0
HFD2_k127_6419066_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 6.001e-216 703.0
HFD2_k127_6419066_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 393.0
HFD2_k127_6419066_2 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000006766 205.0
HFD2_k127_6444700_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1242.0
HFD2_k127_6444700_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0 1116.0
HFD2_k127_6444700_10 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000573 275.0
HFD2_k127_6444700_11 lipopolysaccharide heptosyltransferase I K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006364 291.0
HFD2_k127_6444700_12 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002217 282.0
HFD2_k127_6444700_13 epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008509 270.0
HFD2_k127_6444700_14 PFAM glycosyl transferase family 4 K13007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003559 266.0
HFD2_k127_6444700_15 Bacterial transcriptional repressor C-terminal K09017 - - 0.00000000000000000000000000000000000000000000000000000000000000003397 229.0
HFD2_k127_6444700_16 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000000000003223 201.0
HFD2_k127_6444700_17 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000001991 171.0
HFD2_k127_6444700_18 Sigma-54 interaction domain K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000002598 157.0
HFD2_k127_6444700_19 PFAM Rhodanese domain protein - - - 0.0000000000000000000000000000000003686 140.0
HFD2_k127_6444700_2 TIGRFAM glutamine synthetase, type I K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 2.048e-247 769.0
HFD2_k127_6444700_20 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000002713 112.0
HFD2_k127_6444700_3 CoA-binding domain - - - 7.446e-218 696.0
HFD2_k127_6444700_4 RmlD substrate binding domain K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 439.0
HFD2_k127_6444700_5 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 426.0
HFD2_k127_6444700_6 type I secretion outer membrane protein, TolC K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 422.0
HFD2_k127_6444700_7 3-Deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 401.0
HFD2_k127_6444700_8 Glycosyl transferase family 2 K12984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 348.0
HFD2_k127_6444700_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 323.0
HFD2_k127_6450638_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.88e-298 929.0
HFD2_k127_6450638_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 1.258e-285 884.0
HFD2_k127_6450638_10 CoA binding domain - - - 0.00000000000000000000001518 102.0
HFD2_k127_6450638_2 Acyl-CoA dehydrogenase N terminal K20035 - - 6.417e-252 789.0
HFD2_k127_6450638_3 Electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 449.0
HFD2_k127_6450638_4 MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 434.0
HFD2_k127_6450638_5 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 393.0
HFD2_k127_6450638_6 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001697 277.0
HFD2_k127_6450638_7 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000001815 203.0
HFD2_k127_6450638_8 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000000008075 162.0
HFD2_k127_6450638_9 Thioesterase superfamily K07107 - - 0.0000000000000000000000000000000005331 140.0
HFD2_k127_6510917_0 DNA polymerase K02337 - 2.7.7.7 0.0 1409.0
HFD2_k127_6510917_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1157.0
HFD2_k127_6510917_10 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003973 539.0
HFD2_k127_6510917_11 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 535.0
HFD2_k127_6510917_12 Histidine Phosphotransfer domain K10715 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 555.0
HFD2_k127_6510917_13 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008807 469.0
HFD2_k127_6510917_14 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 481.0
HFD2_k127_6510917_15 Mediates influx of magnesium ions K03284,K16074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 449.0
HFD2_k127_6510917_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 452.0
HFD2_k127_6510917_17 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 414.0
HFD2_k127_6510917_18 HD domain K13815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 392.0
HFD2_k127_6510917_19 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 390.0
HFD2_k127_6510917_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 5.664e-290 900.0
HFD2_k127_6510917_20 Queuosine biosynthesis protein K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000717 389.0
HFD2_k127_6510917_21 Pfam Enoyl-CoA hydratase isomerase K13816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 346.0
HFD2_k127_6510917_22 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 317.0
HFD2_k127_6510917_23 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007543 313.0
HFD2_k127_6510917_24 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 286.0
HFD2_k127_6510917_25 Deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 286.0
HFD2_k127_6510917_26 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001344 267.0
HFD2_k127_6510917_27 Iron-containing redox enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009181 245.0
HFD2_k127_6510917_28 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001701 255.0
HFD2_k127_6510917_29 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000001471 234.0
HFD2_k127_6510917_3 Glucose inhibited division protein A - - - 8.05e-226 707.0
HFD2_k127_6510917_30 - - - - 0.000000000000000000000000000000000000000000000000000000000004311 217.0
HFD2_k127_6510917_31 COG0210 Superfamily I DNA and RNA helicases K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000005347 199.0
HFD2_k127_6510917_32 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000005515 194.0
HFD2_k127_6510917_33 Protein of unknown function (DUF1643) - - - 0.000000000000000000000000000000000000000000000000000197 195.0
HFD2_k127_6510917_34 TIGRFAM DnaA regulatory inactivator Hda K10763 - - 0.000000000000000000000000000000000000000000000000007506 187.0
HFD2_k127_6510917_35 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000001377 184.0
HFD2_k127_6510917_36 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000001614 165.0
HFD2_k127_6510917_37 preprotein translocase subunit YajC K03210 - - 0.0000000000000000000000000000000000001568 143.0
HFD2_k127_6510917_38 alpha beta - - - 0.00000000000000000000000000000000004533 155.0
HFD2_k127_6510917_39 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000002202 124.0
HFD2_k127_6510917_4 ABC transporter C-terminal domain K15738 - - 3.017e-223 713.0
HFD2_k127_6510917_40 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000001096 113.0
HFD2_k127_6510917_41 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000001458 87.0
HFD2_k127_6510917_42 Helix-turn-helix domain - - - 0.00000000000007055 76.0
HFD2_k127_6510917_43 FAD binding domain K09828 - 1.3.1.72 0.000000000007628 72.0
HFD2_k127_6510917_5 Tripartite ATP-independent periplasmic transporter, DctM component - - - 5.64e-198 625.0
HFD2_k127_6510917_6 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 1.837e-196 624.0
HFD2_k127_6510917_7 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 605.0
HFD2_k127_6510917_8 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 603.0
HFD2_k127_6510917_9 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 558.0
HFD2_k127_6521467_0 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 7.292e-204 645.0
HFD2_k127_6521467_1 III protein, CoA-transferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 476.0
HFD2_k127_6521467_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 392.0
HFD2_k127_6521467_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 397.0
HFD2_k127_6521467_4 Taurine catabolism dioxygenase TauD, TfdA family K06912 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 358.0
HFD2_k127_6521467_5 PFAM conserved - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 360.0
HFD2_k127_6551547_0 Methyl-accepting chemotaxis protein K02660 - - 4.314e-209 671.0
HFD2_k127_6551547_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006946 463.0
HFD2_k127_6551547_2 Histidine kinase K02487,K06596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 431.0
HFD2_k127_6551547_3 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 406.0
HFD2_k127_6551547_4 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000007659 203.0
HFD2_k127_6551547_5 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000000000000000000007092 183.0
HFD2_k127_6551547_6 GrpE K03687 - - 0.00000000000000000000000000000000000000000001924 169.0
HFD2_k127_6551547_7 Chemotaxis signal transduction protein K02659 - - 0.00000000000000000000000000000000000004407 158.0
HFD2_k127_6570823_0 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001474 276.0
HFD2_k127_6570823_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001519 265.0
HFD2_k127_6570823_2 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005905 244.0
HFD2_k127_6570823_3 - - - - 0.000000000000000000579 95.0
HFD2_k127_6570823_4 Predicted membrane protein (DUF2306) - - - 0.00000007341 54.0
HFD2_k127_6570823_5 2TM domain - - - 0.00001476 48.0
HFD2_k127_661229_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 546.0
HFD2_k127_661229_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 357.0
HFD2_k127_6671207_0 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001321 255.0
HFD2_k127_6671207_1 regulator of disulfide bond formation K07397 - - 0.0000000000000000000000000000000000000000000000000000000000000003474 222.0
HFD2_k127_6671207_2 - - - - 0.000000000000000000000000000000000009685 141.0
HFD2_k127_6693344_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 7.977e-205 648.0
HFD2_k127_6693344_1 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000005535 153.0
HFD2_k127_6703992_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 2.536e-262 822.0
HFD2_k127_6703992_1 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 510.0
HFD2_k127_6703992_2 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 471.0
HFD2_k127_6703992_3 COG1233 Phytoene dehydrogenase and related proteins K09516,K09835 - 1.3.99.23,5.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006211 299.0
HFD2_k127_6715418_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 2.036e-286 893.0
HFD2_k127_6715418_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 460.0
HFD2_k127_6715418_2 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 420.0
HFD2_k127_6715418_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 305.0
HFD2_k127_673124_0 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 1.712e-236 748.0
HFD2_k127_673124_1 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 379.0
HFD2_k127_673124_2 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001834 282.0
HFD2_k127_673124_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002319 258.0
HFD2_k127_673124_4 Protein of unknown function DUF58 - - - 0.000000000000000000000000000008863 126.0
HFD2_k127_6766696_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1384.0
HFD2_k127_6766696_1 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.697e-244 764.0
HFD2_k127_6766696_2 Citrate synthase, C-terminal domain K01659 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 0.0000000000000002797 78.0
HFD2_k127_6766696_3 Protein of unknown function (DUF3460) - - - 0.0000000001683 65.0
HFD2_k127_6776695_0 PLD-like domain K06132 - - 1.138e-206 661.0
HFD2_k127_6776695_1 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 401.0
HFD2_k127_6776695_10 biosynthesis - - - 0.00000000000000000000000000000000003773 136.0
HFD2_k127_6776695_11 Domain of unknown function (DUF4405) - - - 0.000000000000000000000000000008369 121.0
HFD2_k127_6776695_2 Dehydrogenase K15054 - 1.1.99.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 409.0
HFD2_k127_6776695_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 304.0
HFD2_k127_6776695_4 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004183 228.0
HFD2_k127_6776695_5 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000008423 220.0
HFD2_k127_6776695_6 Belongs to the PsiE family K13256 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000001924 209.0
HFD2_k127_6776695_7 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000000000000000000000000003975 211.0
HFD2_k127_6776695_8 DinB family - - - 0.000000000000000000000000000000000000000000000000000000002691 204.0
HFD2_k127_6776695_9 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000001023 207.0
HFD2_k127_678564_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 568.0
HFD2_k127_678564_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 321.0
HFD2_k127_678564_2 PFAM Integrase, catalytic core, phage - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 295.0
HFD2_k127_678564_3 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000001191 192.0
HFD2_k127_678564_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000005419 173.0
HFD2_k127_678564_5 TonB C terminal K03646 - - 0.000000000000000000000000000000001509 136.0
HFD2_k127_6813321_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 424.0
HFD2_k127_6813321_1 Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily K00001,K00344 - 1.1.1.1,1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 400.0
HFD2_k127_6813321_2 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000004687 221.0
HFD2_k127_6813321_3 glutaminyl-tRNA synthetase K01886 - 6.1.1.18 0.0000000000000000000000000000000000000000000000000000000001215 206.0
HFD2_k127_6813321_4 MarR family - - - 0.0000000000000000000000000000001963 129.0
HFD2_k127_6813321_5 Rhodanese Homology Domain - - - 0.00000000000000000000000000006794 123.0
HFD2_k127_6813321_6 Rubrerythrin - - - 0.0000000000000000003192 95.0
HFD2_k127_6813321_7 Rubrerythrin - - - 0.0001163 51.0
HFD2_k127_6882569_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1143.0
HFD2_k127_6882569_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.562e-299 928.0
HFD2_k127_6882569_10 CHASE2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 527.0
HFD2_k127_6882569_11 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 501.0
HFD2_k127_6882569_12 leucyl aminopeptidase, aminopeptidase T K18028 - 1.13.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 488.0
HFD2_k127_6882569_13 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 475.0
HFD2_k127_6882569_14 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 454.0
HFD2_k127_6882569_15 4Fe-4S ferredoxin iron-sulfur binding domain protein K21834 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 453.0
HFD2_k127_6882569_16 Methionine aminopeptidase K01265 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 442.0
HFD2_k127_6882569_17 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006522 450.0
HFD2_k127_6882569_18 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 440.0
HFD2_k127_6882569_19 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009277 424.0
HFD2_k127_6882569_2 Surface antigen K07277 - - 1.878e-294 926.0
HFD2_k127_6882569_20 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 412.0
HFD2_k127_6882569_21 peptidase, S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 409.0
HFD2_k127_6882569_22 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 409.0
HFD2_k127_6882569_23 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 398.0
HFD2_k127_6882569_24 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 407.0
HFD2_k127_6882569_25 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 399.0
HFD2_k127_6882569_26 Malonyl CoA-acyl carrier protein transacylase K00645,K15355 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 389.0
HFD2_k127_6882569_27 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 385.0
HFD2_k127_6882569_28 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 373.0
HFD2_k127_6882569_29 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 383.0
HFD2_k127_6882569_3 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 8.003e-271 857.0
HFD2_k127_6882569_30 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 369.0
HFD2_k127_6882569_31 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 362.0
HFD2_k127_6882569_32 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 364.0
HFD2_k127_6882569_33 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 361.0
HFD2_k127_6882569_34 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 355.0
HFD2_k127_6882569_35 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 355.0
HFD2_k127_6882569_36 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 351.0
HFD2_k127_6882569_37 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 354.0
HFD2_k127_6882569_38 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 340.0
HFD2_k127_6882569_39 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 340.0
HFD2_k127_6882569_4 Class II Aldolase and Adducin N-terminal domain - - - 1.444e-265 839.0
HFD2_k127_6882569_40 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 323.0
HFD2_k127_6882569_41 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 309.0
HFD2_k127_6882569_42 Sigma E regulatory protein, MucB RseB K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002532 283.0
HFD2_k127_6882569_43 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001056 281.0
HFD2_k127_6882569_44 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001288 267.0
HFD2_k127_6882569_45 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001215 255.0
HFD2_k127_6882569_46 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002845 251.0
HFD2_k127_6882569_47 S-adenosylmethionine-dependent methyltransferase, YraL family K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000001423 243.0
HFD2_k127_6882569_48 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000006526 239.0
HFD2_k127_6882569_49 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000001159 238.0
HFD2_k127_6882569_5 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.201e-234 732.0
HFD2_k127_6882569_50 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000006735 234.0
HFD2_k127_6882569_51 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000002803 231.0
HFD2_k127_6882569_52 Haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000009123 231.0
HFD2_k127_6882569_53 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001117 229.0
HFD2_k127_6882569_54 DNA polymerase III, delta' K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000355 226.0
HFD2_k127_6882569_55 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000000000000000000000003261 217.0
HFD2_k127_6882569_56 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000001044 223.0
HFD2_k127_6882569_57 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000073 203.0
HFD2_k127_6882569_58 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000005861 199.0
HFD2_k127_6882569_59 nitrate reductase activity - - - 0.00000000000000000000000000000000000000000000000000000006122 203.0
HFD2_k127_6882569_6 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 3.983e-227 717.0
HFD2_k127_6882569_60 Belongs to the skp family K06142 - - 0.0000000000000000000000000000000000000000000000000000001946 199.0
HFD2_k127_6882569_61 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000009372 205.0
HFD2_k127_6882569_62 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000366 191.0
HFD2_k127_6882569_63 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000554 180.0
HFD2_k127_6882569_64 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000001679 181.0
HFD2_k127_6882569_65 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000005053 183.0
HFD2_k127_6882569_66 n-acetyltransferase - - - 0.000000000000000000000000000000000000000000745 168.0
HFD2_k127_6882569_67 OmpA family - - - 0.000000000000000000000000000000000000001015 154.0
HFD2_k127_6882569_68 rieske 2fe-2s - - - 0.00000000000000000000000000000000000001218 149.0
HFD2_k127_6882569_69 FecR protein - - - 0.00000000000000000000000000000000000003945 147.0
HFD2_k127_6882569_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 4.732e-217 678.0
HFD2_k127_6882569_70 Protein of unknown function (DUF1178) - - - 0.0000000000000000000000000000000000001173 146.0
HFD2_k127_6882569_71 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000005334 135.0
HFD2_k127_6882569_72 Oligoketide cyclase lipid transport protein - - - 0.000000000000000000000000000000001618 135.0
HFD2_k127_6882569_73 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000001213 125.0
HFD2_k127_6882569_74 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000001484 115.0
HFD2_k127_6882569_75 STAS domain K06378 - - 0.000000000000000000000000001881 116.0
HFD2_k127_6882569_76 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.0000000000000000000008543 108.0
HFD2_k127_6882569_77 Domain of unknown function (DUF4845) - - - 0.000000000000000001021 92.0
HFD2_k127_6882569_78 Histidine kinase-like ATPase domain - - - 0.0000000000000001138 85.0
HFD2_k127_6882569_79 Anti sigma-E protein RseA, N-terminal domain K03597 - - 0.0000000000000001223 88.0
HFD2_k127_6882569_8 Acyl-CoA dehydrogenase, C-terminal domain - - - 2.251e-209 656.0
HFD2_k127_6882569_80 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000003052 79.0
HFD2_k127_6882569_81 Glutaredoxin-like domain (DUF836) - - - 0.00000000000002182 76.0
HFD2_k127_6882569_82 Domain of unknown function (DUF4124) - - - 0.00000000000002209 80.0
HFD2_k127_6882569_84 Domain of unknown function (DUF4936) - - - 0.000000001653 64.0
HFD2_k127_6882569_9 Belongs to the peptidase S1C family K04771 - 3.4.21.107 6.887e-194 617.0
HFD2_k127_690535_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 510.0
HFD2_k127_690535_1 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 443.0
HFD2_k127_690535_2 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 422.0
HFD2_k127_690535_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007431 367.0
HFD2_k127_690535_4 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 359.0
HFD2_k127_690535_5 Protein of unknown function (DUF3302) - - - 0.0000000000000000000000000000000001248 141.0
HFD2_k127_690535_7 Tetratricopeptide repeat - - - 0.0001597 55.0
HFD2_k127_690535_8 metallophosphoesterase - - - 0.0009593 44.0
HFD2_k127_6919726_0 Flavin-binding monooxygenase-like K07222 - - 6.388e-253 795.0
HFD2_k127_6919726_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 1.176e-197 621.0
HFD2_k127_6919726_10 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000003601 180.0
HFD2_k127_6919726_11 Glutaredoxin - - - 0.00000000000000000000000000000000000000000000001328 173.0
HFD2_k127_6919726_12 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000002516 173.0
HFD2_k127_6919726_13 - - - - 0.00000000000000000000000000000000000002054 157.0
HFD2_k127_6919726_14 HNH nucleases - - - 0.0000000000000000000000000000000000002253 143.0
HFD2_k127_6919726_15 HIT domain K19710 - 2.7.7.53 0.0000000000000000000000000000000000007567 149.0
HFD2_k127_6919726_16 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000005097 119.0
HFD2_k127_6919726_17 nuclease - - - 0.00000000000000000002492 102.0
HFD2_k127_6919726_18 PIN domain - - - 0.0000000000000000004216 98.0
HFD2_k127_6919726_19 Protein of unknown function (DUF3293) - - - 0.000000000000000002631 93.0
HFD2_k127_6919726_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 498.0
HFD2_k127_6919726_20 CAAX amino terminal protease family K07052 - - 0.00005853 54.0
HFD2_k127_6919726_3 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 454.0
HFD2_k127_6919726_4 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 445.0
HFD2_k127_6919726_5 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 397.0
HFD2_k127_6919726_6 Quinone oxidoreductase K00001,K00344 - 1.1.1.1,1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 359.0
HFD2_k127_6919726_7 SMART metal-dependent phosphohydrolase, HD region K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000201 256.0
HFD2_k127_6919726_8 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000004332 273.0
HFD2_k127_6919726_9 3'-5' exonuclease - - - 0.000000000000000000000000000000000000000000000000007719 187.0
HFD2_k127_6980966_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 451.0
HFD2_k127_6980966_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 336.0
HFD2_k127_6980966_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006154 316.0
HFD2_k127_6980966_3 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002224 282.0
HFD2_k127_6980966_4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000001478 169.0
HFD2_k127_6980966_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000002381 158.0
HFD2_k127_6980966_6 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000004046 140.0
HFD2_k127_6980966_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000006885 106.0
HFD2_k127_7031017_0 AAA domain - - - 1.303e-281 891.0
HFD2_k127_7031017_1 DNA polymerase beta thumb - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 607.0
HFD2_k127_7031017_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 500.0
HFD2_k127_7031017_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 378.0
HFD2_k127_7031017_4 - - - - 0.00000000000000000000000000001919 121.0
HFD2_k127_7031017_5 response to stress - - - 0.00001092 58.0
HFD2_k127_7031017_6 - - - - 0.00002173 48.0
HFD2_k127_7031017_7 MltA-interacting MipA family protein K07274 - - 0.00002858 56.0
HFD2_k127_7080756_0 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 582.0
HFD2_k127_7080756_1 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 290.0
HFD2_k127_7080756_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000003172 49.0
HFD2_k127_7080756_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0003851 45.0
HFD2_k127_7114652_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 3.727e-269 855.0
HFD2_k127_7114652_1 AMP-binding enzyme C-terminal domain K00666 - - 2.776e-245 773.0
HFD2_k127_7114652_10 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000002459 207.0
HFD2_k127_7114652_11 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000000001803 188.0
HFD2_k127_7114652_12 LysR substrate binding domain - - - 0.00000000000000000000000000000005434 133.0
HFD2_k127_7114652_13 - - - - 0.000000000000000000000000000009395 123.0
HFD2_k127_7114652_14 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000001264 120.0
HFD2_k127_7114652_15 Belongs to the universal stress protein A family - - - 0.00000000000003825 85.0
HFD2_k127_7114652_2 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 4.348e-226 713.0
HFD2_k127_7114652_3 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 425.0
HFD2_k127_7114652_4 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 418.0
HFD2_k127_7114652_5 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 402.0
HFD2_k127_7114652_6 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 380.0
HFD2_k127_7114652_7 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006025 350.0
HFD2_k127_7114652_8 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 326.0
HFD2_k127_7114652_9 membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008901 274.0
HFD2_k127_7135415_0 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000007588 185.0
HFD2_k127_7135415_1 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000004953 172.0
HFD2_k127_7135415_2 Protein of unknown function, DUF - - - 0.0000000000000000000000000000000000000003772 155.0
HFD2_k127_7135415_3 Copper binding periplasmic protein CusF - - - 0.0000000000000000001393 89.0
HFD2_k127_7136001_0 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 2.792e-213 677.0
HFD2_k127_7136001_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 507.0
HFD2_k127_7136001_2 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 477.0
HFD2_k127_7136001_3 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 378.0
HFD2_k127_7136001_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007955 273.0
HFD2_k127_7136001_5 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002134 245.0
HFD2_k127_7136001_6 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000004322 161.0
HFD2_k127_7142520_0 PFAM AMP-dependent synthetase and ligase K00666 - - 8.662e-283 894.0
HFD2_k127_7142520_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 2.819e-238 743.0
HFD2_k127_7142520_10 COG0526 Thiol-disulfide isomerase and thioredoxins K03671 - - 0.0000000000000000000000000000000000004005 149.0
HFD2_k127_7142520_11 OsmC-like protein - - - 0.0000000000000000000000000000000002898 138.0
HFD2_k127_7142520_12 PFAM PspC domain K03973 - - 0.000000000000000000189 99.0
HFD2_k127_7142520_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.176e-196 627.0
HFD2_k127_7142520_3 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 440.0
HFD2_k127_7142520_4 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 359.0
HFD2_k127_7142520_5 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 309.0
HFD2_k127_7142520_6 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002188 264.0
HFD2_k127_7142520_7 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000002513 216.0
HFD2_k127_7142520_8 Archease protein family (MTH1598/TM1083) - - - 0.000000000000000000000000000000000000000000000000000006927 192.0
HFD2_k127_7142520_9 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000001069 156.0
HFD2_k127_7161885_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 1.357e-261 817.0
HFD2_k127_7161885_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 1.112e-246 778.0
HFD2_k127_7161885_10 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001817 280.0
HFD2_k127_7161885_11 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002126 284.0
HFD2_k127_7161885_12 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000007964 270.0
HFD2_k127_7161885_13 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005443 256.0
HFD2_k127_7161885_14 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001731 255.0
HFD2_k127_7161885_15 Protein of unknown function (DUF3501) - - - 0.000000000000000000000000000000000000000000000000000000000000000009661 234.0
HFD2_k127_7161885_16 COG0739 Membrane proteins related to metalloendopeptidases K06194 - - 0.0000000000000000000000000000000000000000000000000000000000005748 225.0
HFD2_k127_7161885_17 PFAM regulatory protein, MerR - - - 0.0000000000000000000000000000000000000000000000001285 179.0
HFD2_k127_7161885_18 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000000006533 176.0
HFD2_k127_7161885_19 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000002436 180.0
HFD2_k127_7161885_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 4.496e-201 649.0
HFD2_k127_7161885_20 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000003106 154.0
HFD2_k127_7161885_21 CNP1-like family - - - 0.000000000000000000000000000000000001566 156.0
HFD2_k127_7161885_22 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000000006379 136.0
HFD2_k127_7161885_3 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008659 569.0
HFD2_k127_7161885_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 524.0
HFD2_k127_7161885_5 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 478.0
HFD2_k127_7161885_6 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 437.0
HFD2_k127_7161885_7 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 424.0
HFD2_k127_7161885_8 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 367.0
HFD2_k127_7161885_9 Transglycosylase SLT domain K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 303.0
HFD2_k127_7215612_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K00481 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0030312,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.14.13.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 364.0
HFD2_k127_7215612_1 trisaccharide binding - - - 0.00000000000000000000007556 102.0
HFD2_k127_7215612_2 Domain of unknown function (DU1801) - - - 0.00000000000004791 83.0
HFD2_k127_7247939_0 MMPL family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004716 503.0
HFD2_k127_7247939_1 Belongs to the beta-ketoacyl-ACP synthases family K00647,K09458 - 2.3.1.179,2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000001532 259.0
HFD2_k127_7247939_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000002376 73.0
HFD2_k127_7254167_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1002.0
HFD2_k127_7254167_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000001604 131.0
HFD2_k127_7276250_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008138 580.0
HFD2_k127_7276250_1 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000093 372.0
HFD2_k127_7276250_10 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.00000000000000000000128 96.0
HFD2_k127_7276250_11 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.000000000000005883 78.0
HFD2_k127_7276250_2 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 337.0
HFD2_k127_7276250_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 319.0
HFD2_k127_7276250_4 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.00000000000000000000000000000000000000000000000000000000000004589 217.0
HFD2_k127_7276250_5 PFAM peptidase S16 lon domain protein K07157 - - 0.0000000000000000000000000000000000000000000079 180.0
HFD2_k127_7276250_6 ribosomal subunit interface protein K05808 - - 0.00000000000000000000000000000000004305 139.0
HFD2_k127_7276250_7 OstA-like protein K09774 - - 0.00000000000000000000000000001153 130.0
HFD2_k127_7276250_8 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000000000000000000000003317 115.0
HFD2_k127_7276250_9 Phosphate starvation-inducible protein, PSIF - - - 0.00000000000000000000007807 106.0
HFD2_k127_7351403_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007733 479.0
HFD2_k127_7351403_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 428.0
HFD2_k127_7351403_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000004205 70.0
HFD2_k127_7368161_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 580.0
HFD2_k127_7368161_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000002117 264.0
HFD2_k127_7368161_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000005684 214.0
HFD2_k127_7369703_0 elongation factor G K02355 - - 1.787e-285 893.0
HFD2_k127_7369703_1 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 357.0
HFD2_k127_7369703_2 GDP-mannose 4,6 dehydratase K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004809 300.0
HFD2_k127_7369703_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001641 284.0
HFD2_k127_7369703_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001366 254.0
HFD2_k127_7369703_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000118 224.0
HFD2_k127_7369703_6 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000007282 109.0
HFD2_k127_7369703_7 Domain of unknown function (DUF4340) - - - 0.00000002233 68.0
HFD2_k127_7408612_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.684e-199 625.0
HFD2_k127_7408612_1 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000004356 192.0
HFD2_k127_7408612_2 rRNA binding K02988 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - 0.0000000000000000001167 88.0
HFD2_k127_7408612_3 Ribosomal protein L30 K02907 - - 0.0000000000000000002048 88.0
HFD2_k127_7447574_0 FAD linked oxidase domain protein - - - 0.0 1716.0
HFD2_k127_7447574_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1146.0
HFD2_k127_7447574_2 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 392.0
HFD2_k127_7447574_3 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 334.0
HFD2_k127_7447574_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 325.0
HFD2_k127_7447574_5 Protein of unknown function (DUF4197) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001485 259.0
HFD2_k127_7447574_6 - - - - 0.000000000000000000000000000000000000000000000000002924 202.0
HFD2_k127_7447574_7 Protein of unknown function (DUF2782) - - - 0.000000000000005589 81.0
HFD2_k127_7472395_0 coenzyme F390 K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004069 396.0
HFD2_k127_7472395_1 - - - - 0.0000000000000000000000000000000000000000000000000006114 196.0
HFD2_k127_7511631_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 6.899e-220 690.0
HFD2_k127_7511631_1 Heat shock 70 kDa protein K04043 - - 1.372e-209 657.0
HFD2_k127_7511631_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 593.0
HFD2_k127_7511631_3 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000000000000000000003585 218.0
HFD2_k127_7511631_4 Extracellular liganD-binding receptor - - - 0.0000000000000000000000000000000000000000000000006004 190.0
HFD2_k127_7569803_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 2.608e-198 632.0
HFD2_k127_7890092_0 amino acid K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 587.0
HFD2_k127_7890092_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 464.0
HFD2_k127_7890092_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009815 434.0
HFD2_k127_7890092_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 430.0
HFD2_k127_7890092_4 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 374.0
HFD2_k127_7890092_5 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000001494 217.0
HFD2_k127_7890092_6 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000259 153.0
HFD2_k127_78930_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 410.0
HFD2_k127_78930_1 (ABC) transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 365.0
HFD2_k127_78930_2 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 353.0
HFD2_k127_78930_3 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000003299 205.0
HFD2_k127_78930_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000007829 157.0
HFD2_k127_7918139_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1311.0
HFD2_k127_7918139_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 4.867e-198 627.0
HFD2_k127_7918139_10 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000001301 199.0
HFD2_k127_7918139_11 Forkhead associated domain - - - 0.000000000000000000000000000000000000000000000000000000412 204.0
HFD2_k127_7918139_12 riboflavin synthase, alpha K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000004757 213.0
HFD2_k127_7918139_13 NMT1-like family - - - 0.000000000000000000000000000000000000000000000005486 184.0
HFD2_k127_7918139_14 Protein of unknown function (DUF3455) - - - 0.00000000000000000000000000000000000000000000007439 174.0
HFD2_k127_7918139_15 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000004677 155.0
HFD2_k127_7918139_16 Etoposide-induced protein 2.4 (EI24) - - - 0.000000000000000000000000000000000000000387 168.0
HFD2_k127_7918139_17 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000004064 136.0
HFD2_k127_7918139_18 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000004277 147.0
HFD2_k127_7918139_19 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000000006875 123.0
HFD2_k127_7918139_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 468.0
HFD2_k127_7918139_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 456.0
HFD2_k127_7918139_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 389.0
HFD2_k127_7918139_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 355.0
HFD2_k127_7918139_6 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 310.0
HFD2_k127_7918139_7 Belongs to the RNA methyltransferase TrmD family K00554 GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 305.0
HFD2_k127_7918139_8 Thiopurine S-methyltransferase (TPMT) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001998 281.0
HFD2_k127_7918139_9 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000001927 212.0
HFD2_k127_796465_0 AMP-dependent synthetase and ligase K01897 - 6.2.1.3 3.85e-259 815.0
HFD2_k127_796465_1 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 498.0
HFD2_k127_796465_2 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 377.0
HFD2_k127_796465_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000002929 210.0
HFD2_k127_7976206_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.42e-284 885.0
HFD2_k127_7976206_1 Orn/Lys/Arg decarboxylase, C-terminal domain K01583 - 4.1.1.19 1.91e-284 887.0
HFD2_k127_7976206_10 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 502.0
HFD2_k127_7976206_11 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 491.0
HFD2_k127_7976206_12 Type I GTP cyclohydrolase folE2 K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 415.0
HFD2_k127_7976206_13 Polyprenyl synthetase K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 391.0
HFD2_k127_7976206_14 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 353.0
HFD2_k127_7976206_15 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 317.0
HFD2_k127_7976206_16 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 299.0
HFD2_k127_7976206_17 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001342 267.0
HFD2_k127_7976206_18 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005041 280.0
HFD2_k127_7976206_19 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000001673 239.0
HFD2_k127_7976206_2 Belongs to the argininosuccinate synthase family. Type 2 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 8.169e-235 745.0
HFD2_k127_7976206_20 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000717 217.0
HFD2_k127_7976206_21 - - - - 0.000000000000000000000000000000000000000000000000000000000004122 216.0
HFD2_k127_7976206_22 Cytochrome c mono- and diheme variants - - - 0.000000000000000000000000000000000000000000000000006378 186.0
HFD2_k127_7976206_23 Aspartyl protease K06985 - - 0.0000000000000000000000000000000000000000000000001822 184.0
HFD2_k127_7976206_24 MAPEG family - - - 0.000000000000000000000000000000000000000000000004834 177.0
HFD2_k127_7976206_25 atpase or kinase K06925 - - 0.000000000000000000000000000000000000000000001007 169.0
HFD2_k127_7976206_26 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000000000000000429 157.0
HFD2_k127_7976206_27 DsrC like protein - - - 0.000000000000000000000000000000000000001419 149.0
HFD2_k127_7976206_28 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000000000000001612 144.0
HFD2_k127_7976206_29 ERAD pathway - - - 0.00000000000000000000000000000000001291 153.0
HFD2_k127_7976206_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 5.021e-213 673.0
HFD2_k127_7976206_30 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000214 87.0
HFD2_k127_7976206_31 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000002564 83.0
HFD2_k127_7976206_32 Tripartite tricarboxylate transporter family receptor - - - 0.000000005181 59.0
HFD2_k127_7976206_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 4.749e-202 655.0
HFD2_k127_7976206_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 8.973e-194 612.0
HFD2_k127_7976206_6 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000591 548.0
HFD2_k127_7976206_7 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 558.0
HFD2_k127_7976206_8 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 541.0
HFD2_k127_7976206_9 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 503.0
HFD2_k127_7982774_0 Transmembrane secretion effector - - - 1.682e-252 794.0
HFD2_k127_7982774_1 Aldehyde dehydrogenase K00128,K00130 - 1.2.1.3,1.2.1.8 4.446e-217 684.0
HFD2_k127_7982774_2 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007982 599.0
HFD2_k127_7982774_3 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00001,K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 503.0
HFD2_k127_7982774_4 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 384.0
HFD2_k127_7982774_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 364.0
HFD2_k127_7982774_6 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000137 227.0
HFD2_k127_8003444_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1564.0
HFD2_k127_8003444_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K21308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 466.0
HFD2_k127_8003444_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004764 336.0
HFD2_k127_8003444_3 reductase beta subunit K00395 - 1.8.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 311.0
HFD2_k127_8003444_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000000000000000002785 218.0
HFD2_k127_8003444_5 reductase, alpha subunit K00394 - 1.8.99.2 0.0000008507 51.0
HFD2_k127_8008876_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 2.877e-205 655.0
HFD2_k127_8008876_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 416.0
HFD2_k127_8008876_2 KR domain K07535 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 295.0
HFD2_k127_8008876_3 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000000278 183.0
HFD2_k127_8008876_4 Rubrerythrin - - - 0.00000000000000000000000000000000159 146.0
HFD2_k127_8008876_5 Putative regulatory protein - - - 0.000000000000000000002222 99.0
HFD2_k127_8012770_0 cation transport ATPase K01533 - 3.6.3.4 2.075e-201 661.0
HFD2_k127_8012770_1 ABC-type transport system, involved in lipoprotein release, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 543.0
HFD2_k127_8012770_2 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 394.0
HFD2_k127_8012770_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 347.0
HFD2_k127_8012770_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 329.0
HFD2_k127_8012770_5 Outer membrane lipoprotein-sorting protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009959 331.0
HFD2_k127_8012770_6 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000004507 208.0
HFD2_k127_8012770_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000692 152.0
HFD2_k127_8012770_8 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000008131 144.0
HFD2_k127_8012770_9 cytochrome oxidase maturation protein cbb3-type - - - 0.000000000004667 70.0
HFD2_k127_8019844_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 543.0
HFD2_k127_8019844_1 Beta-eliminating lyase K01620,K20801 GO:0003674,GO:0003824,GO:0004793,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008732,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050179,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.1.2.48,4.1.2.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 402.0
HFD2_k127_8019844_2 PFAM Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 297.0
HFD2_k127_8019844_3 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000002354 263.0
HFD2_k127_8019844_4 Domain of unknown function (DUF4337) - - - 0.0000000000000000000000000000000000000000000002182 184.0
HFD2_k127_8019844_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000001446 110.0
HFD2_k127_8019844_6 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0001073 46.0
HFD2_k127_8044654_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 5.652e-239 762.0
HFD2_k127_8044654_1 transporter K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 525.0
HFD2_k127_8044654_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 511.0
HFD2_k127_8044654_3 TIGRFAM TonB family protein K03832 - - 0.0000000004804 70.0
HFD2_k127_8077823_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 366.0
HFD2_k127_8077823_1 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001429 284.0
HFD2_k127_8077823_2 Two component transcriptional regulator, LuxR family K13041 - - 0.0000000000000000000000000000000000000000000000000000000000002162 219.0
HFD2_k127_8077823_3 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000001005 209.0
HFD2_k127_8077823_4 Putative Na+/H+ antiporter - - - 0.000000000000000000000000003894 111.0
HFD2_k127_8123435_0 D-aminoacylase domain protein K06015 - 3.5.1.81 4.017e-220 691.0
HFD2_k127_8123435_1 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 469.0
HFD2_k127_8123435_10 MAPEG family - - - 0.0000000000000000000000000002395 118.0
HFD2_k127_8123435_12 Belongs to the UPF0173 family - - - 0.0001461 47.0
HFD2_k127_8123435_2 VWA domain containing CoxE-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 370.0
HFD2_k127_8123435_3 May be involved in the transport of PQQ or its precursor to the periplasm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 370.0
HFD2_k127_8123435_4 Inner membrane protein involved in colicin E2 resistance K06143 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 348.0
HFD2_k127_8123435_5 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002821 274.0
HFD2_k127_8123435_6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141,K19190 - 1.1.1.328,2.7.7.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003554 273.0
HFD2_k127_8123435_7 ATPase MipZ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001117 272.0
HFD2_k127_8123435_8 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000008374 222.0
HFD2_k127_8123435_9 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000000004352 122.0
HFD2_k127_8165790_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.437e-245 769.0
HFD2_k127_8165790_1 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 612.0
HFD2_k127_8165790_2 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 557.0
HFD2_k127_8165790_3 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 364.0
HFD2_k127_8165790_4 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001384 268.0
HFD2_k127_8165790_5 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000007128 185.0
HFD2_k127_8165790_6 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.000000000000000000000000000000000000000000004181 164.0
HFD2_k127_8165790_7 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000005318 156.0
HFD2_k127_8165790_8 - - - - 0.00000000000000000000001501 111.0
HFD2_k127_8205989_0 Sugar (and other) transporter - - - 1.633e-246 771.0
HFD2_k127_8205989_1 Transport of potassium into the cell K03549 - - 3.14e-243 766.0
HFD2_k127_8205989_10 - - - - 0.00000000000000000001607 104.0
HFD2_k127_8205989_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.999e-196 618.0
HFD2_k127_8205989_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 574.0
HFD2_k127_8205989_4 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 336.0
HFD2_k127_8205989_5 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 298.0
HFD2_k127_8205989_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000001446 217.0
HFD2_k127_8205989_7 COG2202 FOG PAS PAC domain - - - 0.0000000000000000000000000000000000000000000000000000000005166 231.0
HFD2_k127_8205989_8 response regulator K13041 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000166 201.0
HFD2_k127_8205989_9 Cold shock protein K03704 - - 0.0000000000000000000000001833 122.0
HFD2_k127_8314027_0 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009127 597.0
HFD2_k127_8314027_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 535.0
HFD2_k127_8314027_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 402.0
HFD2_k127_8314027_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000002341 228.0
HFD2_k127_8314027_4 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000001173 161.0
HFD2_k127_8314027_5 helix_turn_helix, Lux Regulon - - - 0.000002906 59.0
HFD2_k127_8316911_0 AMP-binding enzyme K01895 - 6.2.1.1 6.672e-243 760.0
HFD2_k127_8316911_1 Tripartite tricarboxylate transporter TctA family K07793 - - 2.449e-230 722.0
HFD2_k127_8316911_10 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000001564 199.0
HFD2_k127_8316911_11 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000004579 205.0
HFD2_k127_8316911_12 MaoC like domain - - - 0.0000000000000000000000000000000000000000000004132 170.0
HFD2_k127_8316911_13 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000006014 188.0
HFD2_k127_8316911_15 - - - - 0.0000000000000000000000007374 119.0
HFD2_k127_8316911_2 PFAM Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 467.0
HFD2_k127_8316911_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 454.0
HFD2_k127_8316911_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 446.0
HFD2_k127_8316911_5 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003899 407.0
HFD2_k127_8316911_6 LysR substrate binding domain protein K04761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 388.0
HFD2_k127_8316911_7 (Lipo)protein K07287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 361.0
HFD2_k127_8316911_8 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 301.0
HFD2_k127_8316911_9 Nudix N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001557 276.0
HFD2_k127_8360884_0 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 527.0
HFD2_k127_8360884_1 COG0444 ABC-type dipeptide oligopeptide nickel transport system, ATPase component K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 495.0
HFD2_k127_8360884_10 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000004577 229.0
HFD2_k127_8360884_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000002658 214.0
HFD2_k127_8360884_12 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000001432 207.0
HFD2_k127_8360884_13 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000001131 196.0
HFD2_k127_8360884_14 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000001863 205.0
HFD2_k127_8360884_15 Electron transfer DM13 - - - 0.0000000000000000000000000000000000000000000000005106 191.0
HFD2_k127_8360884_16 - - - - 0.00000000000000000000000000000000000005596 151.0
HFD2_k127_8360884_17 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000001284 104.0
HFD2_k127_8360884_18 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000009392 83.0
HFD2_k127_8360884_19 beta-mannosidase K01192 - 3.2.1.25 0.0002845 52.0
HFD2_k127_8360884_2 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 493.0
HFD2_k127_8360884_3 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 460.0
HFD2_k127_8360884_4 Succinylglutamate desuccinylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 359.0
HFD2_k127_8360884_5 Extradiol ring-cleavage dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 348.0
HFD2_k127_8360884_6 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 308.0
HFD2_k127_8360884_7 probably involved in intracellular septation K06190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004252 252.0
HFD2_k127_8360884_8 peptidylprolyl isomerase K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000004921 258.0
HFD2_k127_8360884_9 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000003844 237.0
HFD2_k127_8381515_0 SNARE associated Golgi protein - - - 2.376e-321 997.0
HFD2_k127_8381515_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 542.0
HFD2_k127_8381515_10 response to abiotic stimulus - - - 0.00000000000000000008351 100.0
HFD2_k127_8381515_11 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000002492 87.0
HFD2_k127_8381515_2 PFAM ATPase family associated with various cellular activities (AAA) K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 415.0
HFD2_k127_8381515_3 Dolichyl-phosphate-mannose-protein mannosyltransferase K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008257 391.0
HFD2_k127_8381515_4 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 308.0
HFD2_k127_8381515_5 Glycosyl transferase group 2 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003306 249.0
HFD2_k127_8381515_6 Thioesterase superfamily protein - - - 0.00000000000000000000000000000000000000000000000007183 181.0
HFD2_k127_8381515_7 - - - - 0.00000000000000000000000000000000000000008246 156.0
HFD2_k127_8381515_8 - - - - 0.000000000000000000000000000000000001329 144.0
HFD2_k127_8381515_9 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000001651 141.0
HFD2_k127_8394936_0 Dihydroorotase, multifunctional complex type K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 563.0
HFD2_k127_8394936_1 PFAM DNA photolyase FAD-binding K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 541.0
HFD2_k127_8394936_10 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000002575 207.0
HFD2_k127_8394936_11 Pyrimidine operon attenuation protein uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000009915 193.0
HFD2_k127_8394936_12 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000009415 190.0
HFD2_k127_8394936_13 Methyl-accepting chemotaxis protein K02660 - - 0.00000000000000000000000000000000000000000000000001971 198.0
HFD2_k127_8394936_14 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000818 122.0
HFD2_k127_8394936_15 Belongs to the UPF0250 family K09158 - - 0.0000000000000000000000000003132 121.0
HFD2_k127_8394936_16 BON domain - - - 0.000000000000000000000816 102.0
HFD2_k127_8394936_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 505.0
HFD2_k127_8394936_3 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 504.0
HFD2_k127_8394936_4 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 430.0
HFD2_k127_8394936_5 Aminotransferase class IV K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 361.0
HFD2_k127_8394936_6 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004078 279.0
HFD2_k127_8394936_7 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005798 269.0
HFD2_k127_8394936_8 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000001683 229.0
HFD2_k127_8394936_9 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000003583 238.0
HFD2_k127_8406818_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 1.483e-213 677.0
HFD2_k127_8406818_1 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 2.595e-195 614.0
HFD2_k127_8406818_10 Nad-dependent epimerase dehydratase K22025 - 1.1.1.410 0.000000001448 60.0
HFD2_k127_8406818_2 PFAM Short-chain dehydrogenase reductase SDR K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 394.0
HFD2_k127_8406818_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 360.0
HFD2_k127_8406818_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 338.0
HFD2_k127_8406818_5 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 330.0
HFD2_k127_8406818_6 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 329.0
HFD2_k127_8406818_7 ZIP Zinc transporter K16267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 297.0
HFD2_k127_8406818_8 synthesis repressor, PhaR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003771 252.0
HFD2_k127_8406818_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000001139 237.0
HFD2_k127_8414856_0 Transport of potassium into the cell K03549 - - 1.222e-266 834.0
HFD2_k127_8414856_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 5.582e-264 824.0
HFD2_k127_8414856_10 PFAM Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002967 254.0
HFD2_k127_8414856_11 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000003117 240.0
HFD2_k127_8414856_12 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000002929 225.0
HFD2_k127_8414856_13 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000008926 184.0
HFD2_k127_8414856_14 Predicted metal-dependent hydrolase K07044 - - 0.00000000000000000000002687 113.0
HFD2_k127_8414856_15 TIGRFAM pentapeptide MXKDX repeat protein - - - 0.00000375 55.0
HFD2_k127_8414856_2 Domain of Unknown Function (DUF748) - - - 8.86e-227 736.0
HFD2_k127_8414856_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 1.795e-194 612.0
HFD2_k127_8414856_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 542.0
HFD2_k127_8414856_5 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 418.0
HFD2_k127_8414856_6 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 409.0
HFD2_k127_8414856_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 411.0
HFD2_k127_8414856_8 CRP FNR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 344.0
HFD2_k127_8414856_9 Cytochrome b/b6/petB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 301.0
HFD2_k127_8439622_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 546.0
HFD2_k127_8439622_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008416 513.0
HFD2_k127_8439622_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 358.0
HFD2_k127_8439622_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 325.0
HFD2_k127_8439622_4 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 298.0
HFD2_k127_8439622_5 Glycosyl Transferase - - - 0.000000000000000000000000000000000000000000000000000000000000001257 235.0
HFD2_k127_8439622_6 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000003108 198.0
HFD2_k127_8439622_7 Beta-ketoacyl synthase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000002925 188.0
HFD2_k127_8439622_8 dehydratase - - - 0.0000000000000000000000000000001294 138.0
HFD2_k127_8442478_0 Alpha beta hydrolase - - - 1.224e-263 822.0
HFD2_k127_8442478_1 poly(R)-hydroxyalkanoic acid synthase K03821 - - 4.57e-251 799.0
HFD2_k127_8442478_10 CDP-alcohol phosphatidyltransferase K00995 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000003665 220.0
HFD2_k127_8442478_11 Thioesterase K07107,K12500 - - 0.0000000000000000000000000000000000000000000000000005952 197.0
HFD2_k127_8442478_12 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000619 177.0
HFD2_k127_8442478_13 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000005043 165.0
HFD2_k127_8442478_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000007634 149.0
HFD2_k127_8442478_15 thiolester hydrolase activity K17362 - - 0.00000000000000000000000003021 124.0
HFD2_k127_8442478_16 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0001746 44.0
HFD2_k127_8442478_17 - - - - 0.0004348 51.0
HFD2_k127_8442478_2 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 3.338e-202 642.0
HFD2_k127_8442478_3 Belongs to the thiolase family K00626 - 2.3.1.9 3.516e-195 616.0
HFD2_k127_8442478_4 Dual specificity phosphatase, catalytic domain K01090 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 494.0
HFD2_k127_8442478_5 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 485.0
HFD2_k127_8442478_6 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007755 438.0
HFD2_k127_8442478_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 394.0
HFD2_k127_8442478_8 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007471 288.0
HFD2_k127_8442478_9 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001505 258.0
HFD2_k127_8564183_0 DNA internalization-related competence protein ComEC Rec2 K02238 - - 1.849e-214 689.0
HFD2_k127_8564183_1 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 548.0
HFD2_k127_8564183_10 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 286.0
HFD2_k127_8564183_11 Belongs to the MtfA family K09933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002371 264.0
HFD2_k127_8564183_12 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005348 263.0
HFD2_k127_8564183_13 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006398 248.0
HFD2_k127_8564183_14 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000001912 185.0
HFD2_k127_8564183_15 COG0655 Multimeric flavodoxin WrbA - - - 0.000000000000000000000000000000000005198 151.0
HFD2_k127_8564183_16 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000001297 134.0
HFD2_k127_8564183_17 Dodecin K09165 - - 0.000000000000000000004668 96.0
HFD2_k127_8564183_18 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07226 - - 0.00000000000000000003759 95.0
HFD2_k127_8564183_2 Major Facilitator Superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 566.0
HFD2_k127_8564183_3 Disulphide bond corrector protein DsbC K04084,K08344 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 554.0
HFD2_k127_8564183_4 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 466.0
HFD2_k127_8564183_5 PFAM secretion protein HlyD family protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 397.0
HFD2_k127_8564183_6 Sodium/hydrogen exchanger family K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 396.0
HFD2_k127_8564183_7 Patatin-like phospholipase K06900 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 357.0
HFD2_k127_8564183_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 344.0
HFD2_k127_8564183_9 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009537 296.0
HFD2_k127_8603150_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.204e-236 736.0
HFD2_k127_8603150_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000003866 83.0
HFD2_k127_8618769_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1206.0
HFD2_k127_8618769_1 DNA helicase K03657 - 3.6.4.12 7.811e-300 942.0
HFD2_k127_8618769_10 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000006302 262.0
HFD2_k127_8618769_11 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006345 251.0
HFD2_k127_8618769_12 Sporulation related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002422 239.0
HFD2_k127_8618769_13 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000009391 244.0
HFD2_k127_8618769_14 Acetyltransferase (GNAT) domain K03829 - - 0.00000000000000000000000000000000000000000000000000000000000000216 227.0
HFD2_k127_8618769_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000008272 222.0
HFD2_k127_8618769_16 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000000000000000000000000000000000000000000000001189 209.0
HFD2_k127_8618769_17 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.00000000000000000000000000000000000000006413 154.0
HFD2_k127_8618769_18 membrane - - - 0.00000000000000000000000000000000000001868 148.0
HFD2_k127_8618769_19 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.0000000000000000000000000000000001938 150.0
HFD2_k127_8618769_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 6.497e-229 720.0
HFD2_k127_8618769_20 KR domain K00059,K03793 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 0.0000000000000000000003154 98.0
HFD2_k127_8618769_21 Autotransporter beta-domain - - - 0.00000000000000007198 95.0
HFD2_k127_8618769_22 Protein of unknown function (DUF2905) - - - 0.0000000000002749 73.0
HFD2_k127_8618769_23 PFAM FecR protein - - - 0.00000000001167 74.0
HFD2_k127_8618769_3 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 610.0
HFD2_k127_8618769_4 Soluble lytic murein transglycosylase L domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008379 522.0
HFD2_k127_8618769_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 409.0
HFD2_k127_8618769_6 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 362.0
HFD2_k127_8618769_7 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 318.0
HFD2_k127_8618769_8 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 317.0
HFD2_k127_8618769_9 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 319.0
HFD2_k127_8642558_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 9.187e-290 900.0
HFD2_k127_8642558_1 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.000000000000000000000000000000000000000000000000001982 191.0
HFD2_k127_8657496_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 2.149e-204 642.0
HFD2_k127_8657496_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 563.0
HFD2_k127_8657496_10 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000004111 50.0
HFD2_k127_8657496_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 376.0
HFD2_k127_8657496_3 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002154 266.0
HFD2_k127_8657496_4 - - - - 0.0000000000000000000000000000000000000000003669 165.0
HFD2_k127_8657496_5 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000005045 143.0
HFD2_k127_8657496_6 - - - - 0.00000000000000000000000000000000001017 148.0
HFD2_k127_8657496_7 - - - - 0.0000000000000000000000000000001048 128.0
HFD2_k127_8657496_8 sulfur carrier activity K04085 - - 0.0000000000000000000000002923 111.0
HFD2_k127_8657496_9 Protein of unknown function (DUF3567) - - - 0.00000000001207 69.0
HFD2_k127_8754614_0 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 368.0
HFD2_k127_8754614_1 Histidine kinase K02482,K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 369.0
HFD2_k127_8754614_2 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 340.0
HFD2_k127_8754614_3 response regulator receiver K13041 - - 0.00000000000000000000000000000000000000000000000000000000000001726 222.0
HFD2_k127_8754614_4 - - - - 0.000000000000000000000000000000000000003544 156.0
HFD2_k127_8754614_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000001027 104.0
HFD2_k127_8754614_6 TIGRFAM 6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000002645 68.0
HFD2_k127_902155_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 4.672e-284 883.0
HFD2_k127_902155_1 Belongs to the peptidase M16 family K07263 - - 6.696e-282 892.0
HFD2_k127_902155_10 cephalosporin hydroxylase - - - 0.000000000000000000000000000000000000000000000000003017 194.0
HFD2_k127_902155_11 OsmC-like protein K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.00000000000000000000000000000000000000000000002853 183.0
HFD2_k127_902155_12 PFAM Cytochrome c, class I - - - 0.0000000000000000000000000032 130.0
HFD2_k127_902155_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000008127 109.0
HFD2_k127_902155_14 - - - - 0.000000000000422 80.0
HFD2_k127_902155_15 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000305 55.0
HFD2_k127_902155_2 VWA domain containing CoxE-like protein K09989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008047 580.0
HFD2_k127_902155_3 Major facilitator Superfamily K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 532.0
HFD2_k127_902155_4 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 478.0
HFD2_k127_902155_5 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 499.0
HFD2_k127_902155_6 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 335.0
HFD2_k127_902155_7 Spermine/spermidine synthase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008783 276.0
HFD2_k127_902155_8 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000001029 220.0
HFD2_k127_902155_9 PFAM extracellular solute-binding protein family 3 K02030,K09969,K10001 - - 0.00000000000000000000000000000000000000000000000000000005504 219.0
HFD2_k127_906061_0 DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 331.0
HFD2_k127_906061_1 SCP-2 sterol transfer family - - - 0.00000000000000000000000000000000000000000000000000000000000007285 218.0
HFD2_k127_906061_2 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000005007 209.0
HFD2_k127_906061_3 4Fe-4S binding domain K21308 - - 0.0000000000000000000000000000000000000000000000008372 175.0
HFD2_k127_906061_4 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000005464 141.0
HFD2_k127_91662_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 2.273e-215 675.0
HFD2_k127_91662_1 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 413.0
HFD2_k127_91662_2 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 399.0
HFD2_k127_91662_3 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 397.0
HFD2_k127_91662_4 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 299.0
HFD2_k127_91662_5 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000739 103.0
HFD2_k127_91662_6 protein conserved in bacteria K09937 - - 0.000000000000000001054 86.0
HFD2_k127_922354_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 605.0
HFD2_k127_922354_1 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 541.0
HFD2_k127_922354_10 TIGRFAM filamentous haemagglutinin family outer membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007025 421.0
HFD2_k127_922354_11 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005884 368.0
HFD2_k127_922354_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 364.0
HFD2_k127_922354_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 337.0
HFD2_k127_922354_14 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 331.0
HFD2_k127_922354_15 PFAM Acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 306.0
HFD2_k127_922354_16 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001241 242.0
HFD2_k127_922354_17 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000000000000000000000004024 194.0
HFD2_k127_922354_18 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000001804 194.0
HFD2_k127_922354_19 PFAM FMN-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000116 188.0
HFD2_k127_922354_2 Transketolase, C-terminal domain K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 534.0
HFD2_k127_922354_20 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000004979 177.0
HFD2_k127_922354_21 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000003004 181.0
HFD2_k127_922354_22 Protein of unknown function (DUF1304) K08987 - - 0.000000000000000000000000000000000000000002057 160.0
HFD2_k127_922354_23 biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000008079 167.0
HFD2_k127_922354_24 domain, Protein - - - 0.00000000000000000000000000000000000002416 168.0
HFD2_k127_922354_25 - - - - 0.0000000000000000000000002755 117.0
HFD2_k127_922354_26 signal transduction histidine kinase - - - 0.000000000000000000000001476 119.0
HFD2_k127_922354_28 Outer membrane protein beta-barrel domain - - - 0.000000000000000001988 93.0
HFD2_k127_922354_29 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000002354 96.0
HFD2_k127_922354_3 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 533.0
HFD2_k127_922354_30 Outer membrane protein beta-barrel domain - - - 0.00000000000000005692 88.0
HFD2_k127_922354_32 - - - - 0.00000000003225 67.0
HFD2_k127_922354_33 - - - - 0.0000000008166 61.0
HFD2_k127_922354_34 - - - - 0.0000009973 51.0
HFD2_k127_922354_36 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00001491 56.0
HFD2_k127_922354_37 Protein of unknown function (DUF3617) - - - 0.0000691 53.0
HFD2_k127_922354_38 Autotransporter beta-domain - - - 0.00008711 57.0
HFD2_k127_922354_4 PFAM monooxygenase FAD-binding K20940 - 1.14.13.218 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 511.0
HFD2_k127_922354_5 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 506.0
HFD2_k127_922354_6 Integral membrane protein TerC family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 455.0
HFD2_k127_922354_7 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 432.0
HFD2_k127_922354_8 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 424.0
HFD2_k127_922354_9 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 382.0
HFD2_k127_943877_0 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1367.0
HFD2_k127_943877_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1071.0
HFD2_k127_943877_10 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 572.0
HFD2_k127_943877_11 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 516.0
HFD2_k127_943877_12 PFAM AFG1-family ATPase K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007626 442.0
HFD2_k127_943877_13 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 430.0
HFD2_k127_943877_14 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 425.0
HFD2_k127_943877_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 400.0
HFD2_k127_943877_16 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000698 395.0
HFD2_k127_943877_17 Pyruvate carboxyltransferase K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 387.0
HFD2_k127_943877_18 PFAM NMT1 THI5 like domain protein K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 359.0
HFD2_k127_943877_19 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 303.0
HFD2_k127_943877_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 2.231e-315 981.0
HFD2_k127_943877_20 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 284.0
HFD2_k127_943877_21 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003743 295.0
HFD2_k127_943877_22 UPF0114 protein - - - 0.000000000000000000000000000000000000000000000000000000000000001902 236.0
HFD2_k127_943877_23 Exonuclease - - - 0.000000000000000000000000000000000000000008335 164.0
HFD2_k127_943877_24 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000000001905 154.0
HFD2_k127_943877_25 Haem-degrading - - - 0.00000000000000000000000000000000005322 141.0
HFD2_k127_943877_26 Haem-degrading - - - 0.00000000000000000000000000000001658 139.0
HFD2_k127_943877_27 - - - - 0.00000000000000000000000000001535 117.0
HFD2_k127_943877_28 membrane - - - 0.0000000000000000000000000001674 119.0
HFD2_k127_943877_29 - - - - 0.000000000000000002529 88.0
HFD2_k127_943877_3 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01908 - 6.2.1.17 8.626e-293 925.0
HFD2_k127_943877_31 Flavinator of succinate dehydrogenase K09159 - - 0.0000000007963 70.0
HFD2_k127_943877_33 - - - - 0.0000004663 51.0
HFD2_k127_943877_4 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.019e-263 823.0
HFD2_k127_943877_5 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.049e-262 817.0
HFD2_k127_943877_6 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.794e-233 726.0
HFD2_k127_943877_7 Dehydrogenase K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 2.949e-215 678.0
HFD2_k127_943877_8 DNA polymerase III is a complex multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3 to 5 exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 590.0
HFD2_k127_943877_9 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 557.0
HFD2_k127_944426_0 PFAM AMP-dependent synthetase and ligase K00666,K01897 - 6.2.1.3 1.892e-216 685.0
HFD2_k127_944426_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008749 447.0
HFD2_k127_944426_2 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 390.0
HFD2_k127_944426_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 374.0
HFD2_k127_944426_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003602 274.0
HFD2_k127_944426_5 Glutathione S-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007278 237.0
HFD2_k127_944426_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001648 228.0
HFD2_k127_944426_7 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000001274 242.0
HFD2_k127_944426_8 - - - - 0.00000000000000000000000000000000006066 150.0
HFD2_k127_944426_9 Pfam:DUF461 K09796 - - 0.000000000000000000000000000001136 128.0
HFD2_k127_944792_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1012.0
HFD2_k127_944792_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 541.0
HFD2_k127_944792_10 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.0000001336 62.0
HFD2_k127_944792_2 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 523.0
HFD2_k127_944792_3 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 513.0
HFD2_k127_944792_4 acyl-CoA transferases carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 449.0
HFD2_k127_944792_5 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 396.0
HFD2_k127_944792_6 SCP-2 sterol transfer family - - - 0.0000000000000000000000000000000000000000000000000000000000006791 218.0
HFD2_k127_944792_7 NnrU protein - - - 0.000000000000000000000000000000000000000000001083 174.0
HFD2_k127_944792_8 Thioesterase - - - 0.000000000000000000000000000000000000006082 149.0
HFD2_k127_944792_9 CHAD - - - 0.0000000000000000009785 97.0
HFD2_k127_950800_0 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006654 477.0
HFD2_k127_950800_1 Dihydroorotate dehydrogenase K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 413.0
HFD2_k127_950800_10 Part of a membrane complex involved in electron transport K03616 - - 0.000000000000000000000244 111.0
HFD2_k127_950800_2 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 353.0
HFD2_k127_950800_3 FES K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 315.0
HFD2_k127_950800_4 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 295.0
HFD2_k127_950800_5 plastoquinol--plastocyanin reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006917 264.0
HFD2_k127_950800_6 PFAM Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001321 254.0
HFD2_k127_950800_7 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000002003 253.0
HFD2_k127_950800_8 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000005843 231.0
HFD2_k127_950800_9 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000005265 188.0
HFD2_k127_985926_0 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 341.0
HFD2_k127_985926_1 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 304.0
HFD2_k127_985926_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000007077 216.0
HFD2_k127_985926_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000006419 177.0
HFD2_k127_98823_0 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 1.941e-303 942.0
HFD2_k127_98823_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007319 634.0
HFD2_k127_98823_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 445.0
HFD2_k127_98823_3 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 305.0
HFD2_k127_98823_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000001352 216.0
HFD2_k127_98824_0 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 3.119e-306 953.0
HFD2_k127_98824_1 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 0.000000000000000000000007175 101.0
HFD2_k127_997801_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 542.0
HFD2_k127_997801_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 448.0
HFD2_k127_997801_2 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 460.0
HFD2_k127_997801_3 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 321.0
HFD2_k127_997801_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009026 286.0
HFD2_k127_997801_5 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000000000000000000000000001349 237.0
HFD2_k127_997801_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000007997 243.0
HFD2_k127_997801_7 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000003692 158.0