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Overview

ID MAG01643
Name HFD2_bin.31
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class JACRHJ01
Order JACRHJ01
Family JACRHJ01
Genus
Species
Assembly information
Completeness (%) 79.33
Contamination (%) 2.01
GC content (%) 56.0
N50 (bp) 8,056
Genome size (bp) 1,878,830

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1875

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1035778_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0 1037.0
HFD2_k127_1035778_1 Conserved hypothetical protein 698 - - - 1.012e-213 672.0
HFD2_k127_1035778_10 Conserved hypothetical protein 698 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001937 258.0
HFD2_k127_1035778_11 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000009216 222.0
HFD2_k127_1035778_12 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000001409 184.0
HFD2_k127_1035778_13 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000000006119 167.0
HFD2_k127_1035778_14 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000005572 153.0
HFD2_k127_1035778_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000000000000000000000595 150.0
HFD2_k127_1035778_16 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.000000000000000000000000000000000001712 140.0
HFD2_k127_1035778_17 PFAM response regulator receiver K22010 - - 0.0000000000000000000000000000000001796 139.0
HFD2_k127_1035778_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000003189 127.0
HFD2_k127_1035778_19 Domain of unknown function DUF302 - - - 0.0000000000000000000001395 109.0
HFD2_k127_1035778_2 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 1.639e-213 687.0
HFD2_k127_1035778_20 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.00000000000000000001934 95.0
HFD2_k127_1035778_21 - - - - 0.000000001455 62.0
HFD2_k127_1035778_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 583.0
HFD2_k127_1035778_4 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 553.0
HFD2_k127_1035778_5 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 490.0
HFD2_k127_1035778_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 436.0
HFD2_k127_1035778_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 402.0
HFD2_k127_1035778_8 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 323.0
HFD2_k127_1035778_9 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002155 255.0
HFD2_k127_1059927_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.209e-278 869.0
HFD2_k127_1059927_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007489 324.0
HFD2_k127_1059927_2 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 303.0
HFD2_k127_1059927_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003502 280.0
HFD2_k127_1059927_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002713 277.0
HFD2_k127_1059927_5 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000006991 209.0
HFD2_k127_1066859_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.458e-305 947.0
HFD2_k127_1066859_1 glycolate transport K14393 - - 1.397e-239 752.0
HFD2_k127_1066859_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 320.0
HFD2_k127_1066859_3 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000001947 213.0
HFD2_k127_1066859_4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000009367 145.0
HFD2_k127_1066859_5 Protein of unknown function, DUF485 - - - 0.00000000000000000000000001897 111.0
HFD2_k127_1066859_6 PFAM PBS lyase HEAT-like repeat - - - 0.0000000000000000000000001792 123.0
HFD2_k127_1066859_7 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000007427 81.0
HFD2_k127_1066859_8 Phosphate-selective porin O and P - - - 0.0000000000001989 83.0
HFD2_k127_106885_0 cytochrome C peroxidase - - - 2.71e-213 673.0
HFD2_k127_106885_1 Anthranilate synthase component I K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 386.0
HFD2_k127_106885_2 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005776 291.0
HFD2_k127_106885_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000001612 246.0
HFD2_k127_106885_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000008774 239.0
HFD2_k127_106885_5 superoxide reductase activity K05919 - 1.15.1.2 0.0000000000000000000000000000000000000000000000000006442 185.0
HFD2_k127_106885_6 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000001852 180.0
HFD2_k127_106885_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000001115 86.0
HFD2_k127_1121326_0 Efflux ABC transporter, permease protein K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004188 258.0
HFD2_k127_1121326_1 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000002096 220.0
HFD2_k127_1121326_2 NosL K19342 - - 0.000000000002555 74.0
HFD2_k127_1121326_3 Domain of unknown function (DUF4418) - - - 0.0000007424 56.0
HFD2_k127_1121767_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 434.0
HFD2_k127_1121767_1 SMART Elongator protein 3 MiaB NifB K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 297.0
HFD2_k127_1121767_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 303.0
HFD2_k127_1121767_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000004039 246.0
HFD2_k127_1128219_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 496.0
HFD2_k127_1128219_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 425.0
HFD2_k127_1128219_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 381.0
HFD2_k127_1128219_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000983 203.0
HFD2_k127_1128219_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000002487 111.0
HFD2_k127_1128219_5 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000608 67.0
HFD2_k127_1128219_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000001121 63.0
HFD2_k127_115768_0 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 377.0
HFD2_k127_115768_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009778 352.0
HFD2_k127_115768_2 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000008234 133.0
HFD2_k127_1231571_0 Domain of unknown function (DUF4143) K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 547.0
HFD2_k127_1231571_1 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 411.0
HFD2_k127_1231571_2 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007225 254.0
HFD2_k127_1231571_3 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001642 225.0
HFD2_k127_1231571_4 RNA recognition motif - - - 0.000000000007779 66.0
HFD2_k127_1264111_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 8.445e-269 848.0
HFD2_k127_1264111_1 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 311.0
HFD2_k127_1264111_2 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000002486 151.0
HFD2_k127_1264111_3 Outer membrane lipoprotein - - - 0.000000000000000000000000001069 126.0
HFD2_k127_1264111_4 TIGRFAM TonB family C-terminal domain K03832 - - 0.000000007406 66.0
HFD2_k127_12666_0 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 383.0
HFD2_k127_12666_1 DNA polymerase alpha chain like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005497 278.0
HFD2_k127_12666_2 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0000000000000000000000000000000000001968 153.0
HFD2_k127_12666_3 cell envelope organization K05807,K08309 - - 0.0000000000000000003159 101.0
HFD2_k127_1267437_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.496e-280 886.0
HFD2_k127_1267437_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 332.0
HFD2_k127_1267437_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000969 263.0
HFD2_k127_1267437_3 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000000003377 210.0
HFD2_k127_1267437_4 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000002578 162.0
HFD2_k127_1267437_5 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.00000000000000000000000000000000000000003833 156.0
HFD2_k127_1267437_6 PilX N-terminal - - - 0.000001571 61.0
HFD2_k127_1360319_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 363.0
HFD2_k127_1360319_1 PFAM Bacterial protein of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 338.0
HFD2_k127_1360319_2 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.000000000000000000000000000000000000000000000004271 179.0
HFD2_k127_1419983_0 PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 3.49e-265 835.0
HFD2_k127_1419983_1 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 3.512e-245 774.0
HFD2_k127_1419983_2 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0000000000000000000000000000000000006565 141.0
HFD2_k127_1419983_3 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.000000000004158 66.0
HFD2_k127_1423076_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.789e-245 767.0
HFD2_k127_1423076_1 SIS domain K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 421.0
HFD2_k127_1423076_2 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008227 350.0
HFD2_k127_1423076_3 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 287.0
HFD2_k127_1423076_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004331 280.0
HFD2_k127_1423076_5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000008523 197.0
HFD2_k127_1423076_6 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000008662 153.0
HFD2_k127_1428325_0 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 497.0
HFD2_k127_1428325_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003374 275.0
HFD2_k127_1428325_2 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001851 242.0
HFD2_k127_1428325_3 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000726 69.0
HFD2_k127_1455230_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 442.0
HFD2_k127_1455230_1 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000006186 188.0
HFD2_k127_1455230_2 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) K07652 - 2.7.13.3 0.0000000000000000000000000000000000000004788 169.0
HFD2_k127_1455230_3 Haloacid dehalogenase-like hydrolase K20866 - 3.1.3.10 0.00000000000000000000000000000000001082 143.0
HFD2_k127_1469312_0 Seven times multi-haem cytochrome CxxCH - - - 0.0000000000000000000000000000000000000006158 156.0
HFD2_k127_1469312_1 Psort location Cytoplasmic, score 8.87 - - - 0.00000000000000000000000000000000000279 147.0
HFD2_k127_1469312_2 Ami_3 K01448 - 3.5.1.28 0.0000000000000000001067 102.0
HFD2_k127_1487976_0 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 463.0
HFD2_k127_1487976_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 296.0
HFD2_k127_1487976_2 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000009494 256.0
HFD2_k127_1487976_3 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001878 243.0
HFD2_k127_1487976_4 glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000002214 201.0
HFD2_k127_1487976_5 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000003376 193.0
HFD2_k127_1487976_6 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000002149 192.0
HFD2_k127_1490856_0 7TM-HD extracellular K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 415.0
HFD2_k127_1490856_1 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 380.0
HFD2_k127_1490856_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 371.0
HFD2_k127_1490856_3 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 364.0
HFD2_k127_1490856_4 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.00000000000000000000000000000000000000000000000000000009375 202.0
HFD2_k127_1490856_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K03474,K03595,K07042 GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 0.000000000000000000000000000001453 126.0
HFD2_k127_1490856_6 Roadblock/LC7 domain - - - 0.000000000000000005527 87.0
HFD2_k127_1490856_7 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000002168 81.0
HFD2_k127_1490856_8 TIGRFAM cytochrome C family protein - - - 0.000000000000004682 79.0
HFD2_k127_1499955_0 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 410.0
HFD2_k127_1499955_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 351.0
HFD2_k127_1499955_2 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 321.0
HFD2_k127_1499955_3 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000001376 221.0
HFD2_k127_1499955_4 EamA-like transporter family - - - 0.000000000000000000000001942 108.0
HFD2_k127_1499955_5 COG0457 FOG TPR repeat - - - 0.00000001169 62.0
HFD2_k127_158908_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 560.0
HFD2_k127_158908_1 SMART Nucleotide binding protein, PINc K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 415.0
HFD2_k127_158908_2 - - - - 0.00000000000000000000000000000000000005266 155.0
HFD2_k127_158908_3 Predicted membrane protein (DUF2318) - - - 0.00000000000000003969 86.0
HFD2_k127_1590906_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 2.405e-242 762.0
HFD2_k127_1590906_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 413.0
HFD2_k127_1590906_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 370.0
HFD2_k127_1590906_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 338.0
HFD2_k127_1590906_4 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 315.0
HFD2_k127_1590906_5 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 270.0
HFD2_k127_1590906_6 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000001439 145.0
HFD2_k127_1590906_7 Polymer-forming cytoskeletal - - - 0.00000000000000000000001881 104.0
HFD2_k127_1604207_0 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 368.0
HFD2_k127_1604207_1 Outer membrane lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000001198 253.0
HFD2_k127_1604207_2 Proline dehydrogenase K00318 GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0046983,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 - 0.000000000000000000000000000000000000000000000000004226 192.0
HFD2_k127_1604207_3 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000003916 140.0
HFD2_k127_1604207_4 COG1413 FOG HEAT repeat K22221 - - 0.000000005381 67.0
HFD2_k127_1604207_5 signal peptide protein - - - 0.00000001947 68.0
HFD2_k127_1604207_6 protein, histidine kinase HAMP region domain protein - - - 0.0001803 53.0
HFD2_k127_1608626_0 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 477.0
HFD2_k127_1608626_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000006521 258.0
HFD2_k127_1608626_10 - - - - 0.000000000000000000000000000202 118.0
HFD2_k127_1608626_11 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000000000000000003584 117.0
HFD2_k127_1608626_12 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000002 100.0
HFD2_k127_1608626_13 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000007532 89.0
HFD2_k127_1608626_14 sulfur carrier activity - GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.000000000000001889 79.0
HFD2_k127_1608626_15 phosphorelay signal transduction system K03413,K07315,K13924 - 2.1.1.80,3.1.1.61,3.1.3.3 0.00000000000008224 77.0
HFD2_k127_1608626_16 DsrE/DsrF-like family - - - 0.00000000001028 69.0
HFD2_k127_1608626_17 Domain of Unknown function (DUF542) K07322 - - 0.00000000004039 65.0
HFD2_k127_1608626_18 DsrE/DsrF-like family K07236 - - 0.000000002547 65.0
HFD2_k127_1608626_19 4Fe-4S binding domain - - - 0.0000002439 53.0
HFD2_k127_1608626_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001604 245.0
HFD2_k127_1608626_21 tRNA wobble position uridine thiolation K07237 GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - 0.00002911 49.0
HFD2_k127_1608626_3 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000005977 241.0
HFD2_k127_1608626_4 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000001652 240.0
HFD2_k127_1608626_5 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000002023 219.0
HFD2_k127_1608626_6 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000178 171.0
HFD2_k127_1608626_7 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000001617 137.0
HFD2_k127_1608626_8 DivIVA protein K04074 - - 0.0000000000000000000000000000003465 127.0
HFD2_k127_1608626_9 YGGT family K02221 - - 0.0000000000000000000000000000006629 124.0
HFD2_k127_1624370_0 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 2.271e-241 769.0
HFD2_k127_1624370_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000002924 245.0
HFD2_k127_1624370_2 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000000000000008347 188.0
HFD2_k127_1624370_3 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000001088 117.0
HFD2_k127_1636613_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 1.032e-200 649.0
HFD2_k127_1636613_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 366.0
HFD2_k127_1636613_2 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000295 291.0
HFD2_k127_1636613_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000004165 228.0
HFD2_k127_1636613_4 MoaC family K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000003908 199.0
HFD2_k127_1636613_5 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000751 92.0
HFD2_k127_1636613_6 glutamine-fructose-6-phosphate transaminase (isomerizing) activity K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.000000000000000008475 83.0
HFD2_k127_1636613_7 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0001627 51.0
HFD2_k127_1699426_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 553.0
HFD2_k127_1699426_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 319.0
HFD2_k127_1699426_2 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000005515 198.0
HFD2_k127_1699426_3 ResB family K07399 - - 0.0000000000000000000000000000000000000000003028 174.0
HFD2_k127_1699426_4 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.000000000000000000000000000000000000000007346 165.0
HFD2_k127_1699426_6 alginic acid biosynthetic process - - - 0.0000000000000000000000002773 114.0
HFD2_k127_1699426_7 HEAT repeat - - - 0.00000000002317 67.0
HFD2_k127_1729970_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 524.0
HFD2_k127_1729970_1 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 417.0
HFD2_k127_1729970_2 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 369.0
HFD2_k127_1729970_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 317.0
HFD2_k127_1729970_4 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000149 289.0
HFD2_k127_1729970_5 response regulator - - - 0.0000000000000000000000000000000000000000000000001403 190.0
HFD2_k127_1729970_6 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.00000000000000000005958 104.0
HFD2_k127_1729970_7 Domain of unknown function (DUF4388) - - - 0.0000000107 65.0
HFD2_k127_1729970_8 Short C-terminal domain - - - 0.00041 49.0
HFD2_k127_1739437_0 CBS domain containing protein K00974 - 2.7.7.72 3.44e-238 755.0
HFD2_k127_1739437_1 integrase domain protein SAM domain protein K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009718 322.0
HFD2_k127_1739437_2 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000001982 226.0
HFD2_k127_1755319_0 ABC transporter K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 377.0
HFD2_k127_1755319_1 WbqC-like protein family - - - 0.000000000000000000000000000000000000000000000000000000000004623 213.0
HFD2_k127_1755319_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000002905 201.0
HFD2_k127_1755319_3 Transport permease protein K09690 - - 0.000000000000000000000000000000000000000000000001773 187.0
HFD2_k127_1755319_4 Winged helix-turn-helix DNA-binding - - - 0.00000000000000000000000000000000000000001303 165.0
HFD2_k127_1755319_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.00000000000000000000000000000005185 135.0
HFD2_k127_1755319_6 spore germination - - - 0.0000000000000000000000000008525 124.0
HFD2_k127_1782723_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 9.756e-210 664.0
HFD2_k127_1782723_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 314.0
HFD2_k127_1782723_2 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000012 182.0
HFD2_k127_1782723_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000003405 171.0
HFD2_k127_1782723_4 Cytochrome c - - - 0.00000000000000000000000000003657 118.0
HFD2_k127_1782723_5 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000002359 113.0
HFD2_k127_1782723_6 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000001183 53.0
HFD2_k127_1804611_0 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 461.0
HFD2_k127_1804611_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 454.0
HFD2_k127_1804611_2 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 444.0
HFD2_k127_1804611_3 Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 397.0
HFD2_k127_1804611_4 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000001399 266.0
HFD2_k127_1804611_5 molybdenum cofactor - - - 0.000000000000000000000000000000000000000000000000000000000001269 214.0
HFD2_k127_1804611_6 MOSC domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000006469 210.0
HFD2_k127_1804611_7 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000001539 184.0
HFD2_k127_1804611_8 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000009416 181.0
HFD2_k127_180896_0 Polysulphide reductase, NrfD - - - 2.348e-200 631.0
HFD2_k127_180896_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 422.0
HFD2_k127_180896_2 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000006983 226.0
HFD2_k127_180896_3 Rubrerythrin - - - 0.000001248 57.0
HFD2_k127_1823584_0 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 503.0
HFD2_k127_1823584_1 TIGRFAM cytochrome C family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 463.0
HFD2_k127_1823584_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 378.0
HFD2_k127_1823584_3 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 306.0
HFD2_k127_1823584_4 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001781 292.0
HFD2_k127_1823584_5 Belongs to the SUA5 family K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000006674 166.0
HFD2_k127_1823584_6 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000008688 129.0
HFD2_k127_1823584_7 RDD family - - - 0.0000000000000000000003573 104.0
HFD2_k127_1823584_8 - - - - 0.0008692 46.0
HFD2_k127_1862342_0 TIGRFAM Ammonium transporter K03320 - - 7.736e-246 770.0
HFD2_k127_1862342_1 nitrogenase component I, alpha chain K02586 - 1.18.6.1 5.573e-235 735.0
HFD2_k127_1862342_2 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 607.0
HFD2_k127_1862342_3 arsenite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 578.0
HFD2_k127_1862342_4 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588,K04037,K11333 - 1.18.6.1,1.3.7.14,1.3.7.15,1.3.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 469.0
HFD2_k127_1862342_5 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 367.0
HFD2_k127_1862342_6 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000003461 173.0
HFD2_k127_1862342_7 - - - - 0.0000000000000000000000000000000003321 132.0
HFD2_k127_1862459_0 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 373.0
HFD2_k127_1862459_1 Belongs to the acetokinase family K00929 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 341.0
HFD2_k127_1862459_2 cytochrome C family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 296.0
HFD2_k127_1862459_3 phosphate butyryltransferase K00634 GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747,GO:0050182 2.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000001581 254.0
HFD2_k127_1862459_4 - - - - 0.00000000000000000000000000000000004969 134.0
HFD2_k127_1862459_5 GHKL domain K13598 - 2.7.13.3 0.0000000000000000000000000000000001448 145.0
HFD2_k127_1862459_6 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000000000000000000000000001365 149.0
HFD2_k127_1862459_7 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.00000000000000000000000000001359 123.0
HFD2_k127_1862459_8 - - - - 0.00000000005481 73.0
HFD2_k127_1910165_0 cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 367.0
HFD2_k127_1910165_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 369.0
HFD2_k127_1910165_2 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002922 305.0
HFD2_k127_1910165_3 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000002317 240.0
HFD2_k127_1910165_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000008854 190.0
HFD2_k127_1910165_5 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000000000000004116 157.0
HFD2_k127_1910165_6 - - - - 0.0000000000000000000000000000000000000002975 170.0
HFD2_k127_1910165_7 HEAT repeat - - - 0.000000000000000000000000000000000000102 154.0
HFD2_k127_1936647_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 9.023e-313 977.0
HFD2_k127_1936647_1 PFAM SPFH domain Band 7 family - - - 0.00000000000000000000000001732 113.0
HFD2_k127_1936647_2 Psort location Cytoplasmic, score - - - 0.000000000000000009091 97.0
HFD2_k127_1936647_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000008054 63.0
HFD2_k127_1936647_4 - - - - 0.000000004404 60.0
HFD2_k127_1941331_0 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 317.0
HFD2_k127_1941331_1 Cytochrome b/b6/petB K03887 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005565 243.0
HFD2_k127_1941331_2 ferrous iron binding K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000000007843 212.0
HFD2_k127_1941331_3 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.000000000000000000000001688 109.0
HFD2_k127_1941331_5 Mor transcription activator family - - - 0.0000000000001284 74.0
HFD2_k127_1941331_6 protein phosphatase 2C domain protein K01090,K20074 - 3.1.3.16 0.000006437 49.0
HFD2_k127_1952277_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000008997 216.0
HFD2_k127_1952277_1 hopanoid biosynthesis associated protein HpnK - - - 0.000000000000000000000000000000000000000000000000000000002374 210.0
HFD2_k127_1952277_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000008463 162.0
HFD2_k127_1952277_3 PFAM Polynucleotide adenylyltransferase region K00974 - 2.7.7.72 0.00000000000000000000000004659 115.0
HFD2_k127_1995664_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 312.0
HFD2_k127_1995664_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000004729 238.0
HFD2_k127_1995664_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000272 199.0
HFD2_k127_1995664_3 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000007257 83.0
HFD2_k127_1995664_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000467 74.0
HFD2_k127_1995664_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.0000002252 56.0
HFD2_k127_1996632_0 Fumarate reductase flavoprotein C-term K00239 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.5.1,1.3.5.4 3.454e-275 856.0
HFD2_k127_1996632_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 390.0
HFD2_k127_1996632_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 381.0
HFD2_k127_1996632_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 331.0
HFD2_k127_1996632_4 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000000008892 159.0
HFD2_k127_1996632_5 - - - - 0.0000000004147 68.0
HFD2_k127_1996632_6 4Fe-4S binding domain - - - 0.000005466 51.0
HFD2_k127_2012764_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 3.966e-202 644.0
HFD2_k127_2012764_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 568.0
HFD2_k127_2012764_10 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - 0.000000000000000006272 92.0
HFD2_k127_2012764_11 Orn Lys Arg decarboxylase major K01582,K01585 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.1.1.18,4.1.1.19 0.0000000000000002826 81.0
HFD2_k127_2012764_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 391.0
HFD2_k127_2012764_3 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000001488 248.0
HFD2_k127_2012764_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000001121 237.0
HFD2_k127_2012764_5 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000002962 211.0
HFD2_k127_2012764_6 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000002234 203.0
HFD2_k127_2012764_7 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000001648 114.0
HFD2_k127_2012764_8 Psort location Cytoplasmic, score 8.96 K01163 - - 0.00000000000000000000000002694 110.0
HFD2_k127_2012764_9 - - - - 0.000000000000000003471 87.0
HFD2_k127_2112672_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 464.0
HFD2_k127_2112672_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 426.0
HFD2_k127_2112672_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 322.0
HFD2_k127_2112672_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000001354 250.0
HFD2_k127_2112672_4 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000000000000001324 245.0
HFD2_k127_2112672_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07651 - 2.7.13.3 0.00000000000000000000000000000000000000000002163 181.0
HFD2_k127_2112672_6 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000001084 155.0
HFD2_k127_2112672_7 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000005696 125.0
HFD2_k127_2112672_8 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000378 94.0
HFD2_k127_2112672_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000155 69.0
HFD2_k127_2168406_0 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 497.0
HFD2_k127_2168406_1 Peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 352.0
HFD2_k127_2168406_2 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000001776 239.0
HFD2_k127_2168406_3 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000002006 208.0
HFD2_k127_2168406_4 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000001304 201.0
HFD2_k127_2168406_5 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000009943 111.0
HFD2_k127_2206190_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.309e-212 684.0
HFD2_k127_2206190_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 355.0
HFD2_k127_2206190_2 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000005548 223.0
HFD2_k127_2206190_3 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000001995 138.0
HFD2_k127_2206190_4 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000001144 135.0
HFD2_k127_2206190_5 membrane - - - 0.00000000000000000000000000022 118.0
HFD2_k127_2256573_0 PLD-like domain K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 405.0
HFD2_k127_2256573_1 methylamine metabolic process K15977 - - 0.00000000000000000000000000000000000000000000000000000000006355 206.0
HFD2_k127_2256573_2 Papain family cysteine protease - - - 0.000000000000000000000000000000000000000000000000000003765 219.0
HFD2_k127_2256573_3 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000007914 168.0
HFD2_k127_2256573_4 cellulase activity - - - 0.000000000000000003597 101.0
HFD2_k127_2256573_5 Domain of unknown function (DUF4082) - - - 0.000000005771 70.0
HFD2_k127_2256573_6 secreted protein K14475 - - 0.00000003709 61.0
HFD2_k127_2260347_0 Elongator protein 3, MiaB family, Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 432.0
HFD2_k127_2260347_1 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 405.0
HFD2_k127_2260347_10 Divergent 4Fe-4S mono-cluster K05337 - - 0.00000000000000001277 84.0
HFD2_k127_2260347_11 PFAM dihydropteroate synthase, DHPS K15023 - 2.1.1.258 0.00000000000000001991 93.0
HFD2_k127_2260347_12 PFAM Carboxymuconolactone decarboxylase - - - 0.000000000000000216 83.0
HFD2_k127_2260347_13 - - - - 0.000000000000001808 78.0
HFD2_k127_2260347_14 chorismate binding enzyme K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.000000000000004415 75.0
HFD2_k127_2260347_2 galactose-1-phosphate K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 379.0
HFD2_k127_2260347_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 308.0
HFD2_k127_2260347_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 306.0
HFD2_k127_2260347_5 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000002738 258.0
HFD2_k127_2260347_6 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000001614 244.0
HFD2_k127_2260347_7 deoxyribose-phosphate aldolase activity K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000003447 226.0
HFD2_k127_2260347_8 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000003385 220.0
HFD2_k127_2260347_9 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000000001961 103.0
HFD2_k127_2280209_0 S1, RNA binding domain K06959 - - 0.0 1042.0
HFD2_k127_2280209_1 PFAM ABC transporter K01990,K13926 - - 2.548e-209 658.0
HFD2_k127_2280209_2 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005874 582.0
HFD2_k127_2317964_0 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 499.0
HFD2_k127_2317964_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 334.0
HFD2_k127_2317964_2 MgtE intracellular N domain - - - 0.0000000000000000000000000000000000009834 144.0
HFD2_k127_2317964_3 Belongs to the ompA family K03286 - - 0.0000000000000000000008861 101.0
HFD2_k127_2317964_4 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000218 97.0
HFD2_k127_2317964_5 PFAM Nucleotidyltransferase domain K07075 - - 0.0000000000000000001237 91.0
HFD2_k127_2317964_6 Belongs to the ompA family K03286 - - 0.000009185 54.0
HFD2_k127_2339748_0 FAD binding domain K00278 - 1.4.3.16 4.182e-195 621.0
HFD2_k127_2339748_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008551 587.0
HFD2_k127_2339748_2 binding-protein-dependent transport systems inner membrane component K02033,K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 407.0
HFD2_k127_2339748_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000002571 230.0
HFD2_k127_2339748_4 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000000000000000000000004522 171.0
HFD2_k127_2339748_5 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000002044 147.0
HFD2_k127_2339748_6 COG0784 FOG CheY-like receiver - - - 0.00000000000000000000000003999 114.0
HFD2_k127_237588_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 2.492e-231 724.0
HFD2_k127_237588_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 7.977e-200 633.0
HFD2_k127_237588_2 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003857 271.0
HFD2_k127_237588_3 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005762 246.0
HFD2_k127_241825_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 9.873e-301 941.0
HFD2_k127_241825_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.871e-206 649.0
HFD2_k127_241825_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 334.0
HFD2_k127_241825_3 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005251 313.0
HFD2_k127_241825_4 PFAM MscS Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000003491 135.0
HFD2_k127_241825_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000041 105.0
HFD2_k127_241825_6 deacetylase K22278 - 3.5.1.104 0.00000000000000000005602 94.0
HFD2_k127_2433518_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 398.0
HFD2_k127_2433518_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000006004 254.0
HFD2_k127_2433518_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.000000000000000000000000000000000000000000000000000000002408 205.0
HFD2_k127_2433518_3 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000001047 107.0
HFD2_k127_2442885_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005048 533.0
HFD2_k127_2442885_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 429.0
HFD2_k127_2467673_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 327.0
HFD2_k127_2467673_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000001568 214.0
HFD2_k127_2467673_2 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000004259 207.0
HFD2_k127_2467673_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000002842 168.0
HFD2_k127_2467673_4 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000005144 163.0
HFD2_k127_2467673_5 Tetratricopeptide repeat K05807 - - 0.000000000000000000000000000000000000000008977 163.0
HFD2_k127_2467673_6 4Fe-4S binding domain - - - 0.000000000000000000004666 94.0
HFD2_k127_2467673_7 Rhs family - - - 0.000000000000000000025 101.0
HFD2_k127_2467673_8 Hep Hag repeat protein - - - 0.00000000000000000003238 106.0
HFD2_k127_2505649_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008712 411.0
HFD2_k127_2505649_1 transmembrane transporter activity K02007,K02008 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 324.0
HFD2_k127_2505649_2 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001744 267.0
HFD2_k127_2505649_3 PFAM ApbE family K09740 - - 0.00000000000000000000000000000000000000000000000000000000000005124 222.0
HFD2_k127_2505649_4 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.0000000000001184 78.0
HFD2_k127_2544_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 387.0
HFD2_k127_2544_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000005873 172.0
HFD2_k127_2544_2 PFAM Metallophosphoesterase K09769 - - 0.00000000000000000000000000000002996 127.0
HFD2_k127_2550430_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 8.355e-200 628.0
HFD2_k127_2550430_1 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 505.0
HFD2_k127_2550430_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 385.0
HFD2_k127_2550430_3 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000009052 186.0
HFD2_k127_2570374_0 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 366.0
HFD2_k127_2570374_1 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000001744 263.0
HFD2_k127_2570374_2 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000004474 166.0
HFD2_k127_2570374_3 methyltransferase activity - - - 0.000000001332 65.0
HFD2_k127_2594778_0 PFAM magnesium chelatase ChlI subunit K07391 - - 5.847e-211 667.0
HFD2_k127_2594778_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 615.0
HFD2_k127_2594778_10 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000000000000000003907 184.0
HFD2_k127_2594778_11 LysE type translocator - - - 0.00000000000000000000000000000000000000000000003216 177.0
HFD2_k127_2594778_12 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000007028 182.0
HFD2_k127_2594778_13 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000002727 177.0
HFD2_k127_2594778_14 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000006041 131.0
HFD2_k127_2594778_15 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000007873 126.0
HFD2_k127_2594778_16 PFAM 4Fe-4S K00176 - 1.2.7.3 0.0000000000000005609 80.0
HFD2_k127_2594778_17 cell adhesion involved in biofilm formation - - - 0.0000000004664 71.0
HFD2_k127_2594778_18 COGs COG1716 FOG FHA domain - - - 0.0000003193 56.0
HFD2_k127_2594778_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 515.0
HFD2_k127_2594778_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 458.0
HFD2_k127_2594778_4 RecF/RecN/SMC N terminal domain K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 434.0
HFD2_k127_2594778_5 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 383.0
HFD2_k127_2594778_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 377.0
HFD2_k127_2594778_7 histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001965 286.0
HFD2_k127_2594778_8 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000001533 237.0
HFD2_k127_2594778_9 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000000002158 191.0
HFD2_k127_2598273_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586,K05366 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 560.0
HFD2_k127_2598273_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 417.0
HFD2_k127_2598273_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009366 312.0
HFD2_k127_2598273_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 309.0
HFD2_k127_2598273_4 Tetratricopeptide repeat - - - 0.000000000000000000001895 100.0
HFD2_k127_2598273_5 Histidine kinase A domain protein - - - 0.000000000000000000008191 94.0
HFD2_k127_2598273_6 Tetratricopeptide repeat - - - 0.00000000000000000001 99.0
HFD2_k127_2598273_7 Nucleotidyltransferase domain - - - 0.0000004763 53.0
HFD2_k127_2662037_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1962.0
HFD2_k127_2662037_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1596.0
HFD2_k127_2662037_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 426.0
HFD2_k127_2662037_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000005136 237.0
HFD2_k127_2662037_4 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000002307 224.0
HFD2_k127_2662037_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000006483 177.0
HFD2_k127_2662037_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000001288 150.0
HFD2_k127_2667788_0 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005374 254.0
HFD2_k127_2667788_1 denitrification pathway K02569,K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000002939 238.0
HFD2_k127_2667788_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000746 141.0
HFD2_k127_2667788_3 regulatory protein, FmdB family - - - 0.0000000000000000000006219 98.0
HFD2_k127_2667788_4 PFAM NHL repeat containing protein - - - 0.00000000000000001228 91.0
HFD2_k127_270080_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 394.0
HFD2_k127_270080_1 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 329.0
HFD2_k127_270080_2 - - - - 0.0000000000000000000000000000000000674 145.0
HFD2_k127_270080_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840 GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.8 0.00000000000000000004866 90.0
HFD2_k127_270080_4 PFAM pyridoxamine 5'-phosphate K07006 - - 0.0000000000000001057 85.0
HFD2_k127_2726699_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 301.0
HFD2_k127_2726699_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001232 280.0
HFD2_k127_2726699_2 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001076 234.0
HFD2_k127_2726699_3 PFAM sulfatase - - - 0.000000000000000000000000000000000000000000000001978 195.0
HFD2_k127_2726699_4 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000006812 175.0
HFD2_k127_2726699_5 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000006128 165.0
HFD2_k127_2726699_6 Methyltransferase domain - - - 0.0000000000000004474 89.0
HFD2_k127_2726699_7 Psort location CytoplasmicMembrane, score - - - 0.0000005318 54.0
HFD2_k127_2726699_8 Domain of unknown function (DUF1736) - - - 0.0001641 52.0
HFD2_k127_2736807_0 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 485.0
HFD2_k127_2736807_1 chemotaxis K03408 - - 0.0000000000000000000000000000000000000001481 156.0
HFD2_k127_2747165_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 466.0
HFD2_k127_2747165_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 297.0
HFD2_k127_2747165_2 PFAM Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004646 282.0
HFD2_k127_2747165_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000001843 194.0
HFD2_k127_286376_0 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 395.0
HFD2_k127_286376_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 329.0
HFD2_k127_286376_2 PFAM HPP family K07168 - - 0.000000000000000000000000000000000000000000000000000000000000000000001445 244.0
HFD2_k127_286376_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000002239 141.0
HFD2_k127_286376_4 PFAM CBS domain - - - 0.00000000000000000000000000000004701 132.0
HFD2_k127_286376_5 4'-phosphopantetheinyl transferase superfamily K00997 - 2.7.8.7 0.0000000000000000000000000000004352 126.0
HFD2_k127_286376_6 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000122 100.0
HFD2_k127_2975072_0 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 600.0
HFD2_k127_2975072_1 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 515.0
HFD2_k127_2975072_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 329.0
HFD2_k127_2975072_3 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001418 276.0
HFD2_k127_2975072_4 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000006004 170.0
HFD2_k127_2975072_5 Conserved hypothetical protein 95 - - - 0.0000000000000000000000000000000000001671 148.0
HFD2_k127_2975072_6 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000005279 108.0
HFD2_k127_2975072_7 Tetratricopeptide TPR_2 repeat protein K12600 - - 0.0000000000000001747 93.0
HFD2_k127_2975072_8 thiamine biosynthesis protein ThiS K03154 - - 0.0000000004272 63.0
HFD2_k127_307293_0 glutamate synthase (NADPH), homotetrameric K00123,K00266 - 1.17.1.9,1.4.1.13,1.4.1.14 3.89e-251 797.0
HFD2_k127_307293_1 TIGRFAM sulfite reductase, dissimilatory-type beta subunit K11181 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 524.0
HFD2_k127_307293_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 503.0
HFD2_k127_307293_3 sulfur carrier activity - - - 0.0000000000000000002793 90.0
HFD2_k127_307293_5 Rubrerythrin - - - 0.0006305 51.0
HFD2_k127_3109826_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 4.024e-238 754.0
HFD2_k127_3109826_1 GTP-binding protein TypA K06207 - - 5.766e-237 749.0
HFD2_k127_3109826_11 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000004455 70.0
HFD2_k127_3109826_2 Domain of unknown function (DUF3463) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 415.0
HFD2_k127_3109826_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 338.0
HFD2_k127_3109826_4 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 301.0
HFD2_k127_3109826_5 intermembrane phospholipid transfer K07323 - - 0.00000000000000000000000000000000000000000000000000000000000000531 222.0
HFD2_k127_3109826_6 SAM-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000001832 193.0
HFD2_k127_3109826_7 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000001299 186.0
HFD2_k127_3109826_8 Permease MlaE K02066 - - 0.00000000000000000000000000000000000001221 146.0
HFD2_k127_3109826_9 PFAM NHL repeat containing protein - - - 0.000000000000000000000000004095 120.0
HFD2_k127_3143716_0 phosphorelay signal transduction system K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 530.0
HFD2_k127_3143716_1 PFAM type II secretion system K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 510.0
HFD2_k127_3143716_2 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 352.0
HFD2_k127_3143716_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 291.0
HFD2_k127_3143716_4 -O-antigen K02847,K13009,K16705 GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000009445 245.0
HFD2_k127_3143716_5 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0000000000000000000000000003706 121.0
HFD2_k127_3143716_6 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000008692 121.0
HFD2_k127_3143716_7 Type IV pilin PilA K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000000000000000000081 96.0
HFD2_k127_3149415_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 552.0
HFD2_k127_3149415_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 385.0
HFD2_k127_3149415_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 322.0
HFD2_k127_3149415_3 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000000000000000000000000000000000003858 234.0
HFD2_k127_3149415_4 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000001641 173.0
HFD2_k127_3149415_5 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000199 166.0
HFD2_k127_3149415_6 Domain of unknown function (DUF296) - - - 0.00000000000000000000000000000000000007517 146.0
HFD2_k127_3149415_7 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000001815 157.0
HFD2_k127_3149415_8 Nad-dependent epimerase dehydratase - - - 0.00000000000000003137 92.0
HFD2_k127_3149415_9 - - - - 0.0001689 46.0
HFD2_k127_3188870_0 phosphorelay signal transduction system K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 423.0
HFD2_k127_3188870_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 334.0
HFD2_k127_3188870_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000001344 213.0
HFD2_k127_3188870_3 12 heme-binding sites - - - 0.000000000000000000000000000000000000000000000000000203 203.0
HFD2_k127_3188870_4 PFAM 4Fe-4S binding domain K00184,K08358 - - 0.0000000000000000000000000000000000000008403 151.0
HFD2_k127_3188870_5 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000003599 140.0
HFD2_k127_3207087_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 4.033e-210 661.0
HFD2_k127_3207087_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 607.0
HFD2_k127_3207087_10 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000003359 211.0
HFD2_k127_3207087_11 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000115 167.0
HFD2_k127_3207087_12 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000002067 147.0
HFD2_k127_3207087_13 Metallo-beta-lactamase - - - 0.00000000000000008761 80.0
HFD2_k127_3207087_14 cellulase activity - - - 0.00001491 56.0
HFD2_k127_3207087_2 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 602.0
HFD2_k127_3207087_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 589.0
HFD2_k127_3207087_4 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 579.0
HFD2_k127_3207087_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 415.0
HFD2_k127_3207087_6 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 308.0
HFD2_k127_3207087_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009073 291.0
HFD2_k127_3207087_8 Belongs to the TrpC family K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000105 253.0
HFD2_k127_3207087_9 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000001288 221.0
HFD2_k127_3208488_0 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 323.0
HFD2_k127_3208488_1 Fumarase C C-terminus K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000005458 178.0
HFD2_k127_3253389_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 4.852e-197 622.0
HFD2_k127_3253389_1 YbbR-like protein - - - 0.0000000000000000000000000225 116.0
HFD2_k127_3291743_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.22e-307 974.0
HFD2_k127_3291743_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001345 267.0
HFD2_k127_3291743_2 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000000000000000000000000000000000000000001523 226.0
HFD2_k127_3291743_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000001602 203.0
HFD2_k127_3291743_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000005866 204.0
HFD2_k127_3291743_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000005648 165.0
HFD2_k127_3291743_6 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000002846 106.0
HFD2_k127_3291743_7 - - - - 0.0000001051 57.0
HFD2_k127_3301660_0 4 iron, 4 sulfur cluster binding - - - 6.927e-243 773.0
HFD2_k127_3301660_1 - - - - 0.00000000000000001443 87.0
HFD2_k127_330610_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 591.0
HFD2_k127_330610_1 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.0000000000000000000000001182 110.0
HFD2_k127_330610_2 transcriptional regulator K07726 - - 0.000000000000000000000433 98.0
HFD2_k127_330610_3 - - - - 0.00001655 49.0
HFD2_k127_330610_4 - - - - 0.0000344 48.0
HFD2_k127_3316203_0 MazG family K02428,K02499 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 299.0
HFD2_k127_3316203_1 ATP binding cassette transporter ABC protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001336 282.0
HFD2_k127_3316203_2 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.0000000000000000000004308 104.0
HFD2_k127_3316203_3 - - - - 0.00000000000005382 78.0
HFD2_k127_3316203_4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000001414 80.0
HFD2_k127_3316203_5 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00008611 53.0
HFD2_k127_332538_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005821 542.0
HFD2_k127_332538_1 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000005699 259.0
HFD2_k127_332538_2 ribose 5-phosphate isomerase B K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000006704 199.0
HFD2_k127_332538_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000001374 195.0
HFD2_k127_332538_4 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000004871 168.0
HFD2_k127_3347332_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 590.0
HFD2_k127_3347332_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 283.0
HFD2_k127_3347332_2 Putative inner membrane exporter, YdcZ K09936 - - 0.000000000000000000000000000000000000002518 151.0
HFD2_k127_3347332_3 - - - - 0.0000000001709 68.0
HFD2_k127_3347332_4 - - - - 0.00000731 51.0
HFD2_k127_3376212_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003337 262.0
HFD2_k127_3376212_1 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000001129 203.0
HFD2_k127_3376212_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000158 155.0
HFD2_k127_3376212_3 Glycosyl transferase 4-like domain - - - 0.000000007251 67.0
HFD2_k127_3391015_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 557.0
HFD2_k127_3391015_1 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000003647 214.0
HFD2_k127_3391015_2 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.000000000000000000000000000000000000000002062 162.0
HFD2_k127_3391015_3 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000514 144.0
HFD2_k127_3416274_0 PFAM type II secretion system protein E K02283,K03609 - - 4.691e-195 617.0
HFD2_k127_3416274_1 ATPase with chaperone activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 547.0
HFD2_k127_3416274_10 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000002839 111.0
HFD2_k127_3416274_11 Putative Tad-like Flp pilus-assembly - - - 0.00000000006158 75.0
HFD2_k127_3416274_12 TadE-like protein - - - 0.00000052 57.0
HFD2_k127_3416274_13 PFAM Flp Fap pilin component K02651 - - 0.000003812 51.0
HFD2_k127_3416274_14 PFAM Flp Fap pilin component K02651 - - 0.0000197 50.0
HFD2_k127_3416274_15 TadE-like protein - - - 0.0001564 51.0
HFD2_k127_3416274_2 DNA polymerase A domain K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 547.0
HFD2_k127_3416274_3 Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001562 285.0
HFD2_k127_3416274_4 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007165 254.0
HFD2_k127_3416274_5 Pilus formation protein N terminal region K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001761 260.0
HFD2_k127_3416274_6 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000606 253.0
HFD2_k127_3416274_7 Flp pilus assembly protein K12511 - - 0.000000000000000000000000000000000000000000000000000000000000009177 227.0
HFD2_k127_3416274_8 TIGRFAM Flp pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000003782 218.0
HFD2_k127_3416274_9 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000001557 145.0
HFD2_k127_3418878_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 4.617e-290 902.0
HFD2_k127_3418878_1 LexA-binding, inner membrane-associated putative hydrolase - - - 0.000000000000000000000000000000000000000000000000000000377 198.0
HFD2_k127_3418878_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000001641 172.0
HFD2_k127_3418878_4 - - - - 0.000000000000000001102 93.0
HFD2_k127_3471612_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000009825 119.0
HFD2_k127_3471612_1 Flavin containing amine oxidoreductase K09835 - 5.2.1.13 0.000000000000000000002898 108.0
HFD2_k127_3471612_2 Domain of unknown function (DUF4410) - - - 0.00000000000000000004802 97.0
HFD2_k127_3471612_3 Flavin containing amine oxidoreductase - - - 0.0000000006852 71.0
HFD2_k127_3471612_4 Amidohydrolase K22213 - 4.1.1.52 0.00000005405 59.0
HFD2_k127_3483235_0 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000411 496.0
HFD2_k127_3483235_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 336.0
HFD2_k127_3483235_2 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000005754 188.0
HFD2_k127_3483235_3 Histidine kinase K07651 - 2.7.13.3 0.000000000000000000000000000000000000000000000000005373 200.0
HFD2_k127_3483235_4 Histidine kinase K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000008044 187.0
HFD2_k127_3483235_5 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000001575 176.0
HFD2_k127_3483235_6 energy transducer activity K03832 - - 0.0000000000000000000002268 108.0
HFD2_k127_3483235_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000111 87.0
HFD2_k127_3488009_0 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 313.0
HFD2_k127_3488009_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000006386 214.0
HFD2_k127_3488009_2 Cys-tRNA(Pro) hydrolase activity K03976,K19055 - - 0.00000000000000000000000000000000000000000317 160.0
HFD2_k127_3488009_3 Thioesterase superfamily - - - 0.0000000000000000000000000000005432 127.0
HFD2_k127_3493099_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 1.054e-289 904.0
HFD2_k127_3493099_1 Pfam Copper resistance K07245 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 484.0
HFD2_k127_3493099_2 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 456.0
HFD2_k127_3493099_3 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 378.0
HFD2_k127_3493099_4 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 312.0
HFD2_k127_3493099_5 SURF4 family K15977 - - 0.00000000000000000000000000000000000000003394 156.0
HFD2_k127_3493099_6 response to copper ion K07156 - - 0.00000000000002041 78.0
HFD2_k127_3493099_7 Histidine kinase - - - 0.00000005049 54.0
HFD2_k127_3493099_8 PilZ domain - - - 0.0004405 51.0
HFD2_k127_3533134_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 5.875e-204 645.0
HFD2_k127_3533134_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 396.0
HFD2_k127_3533134_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 382.0
HFD2_k127_3533134_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 362.0
HFD2_k127_3533134_4 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 342.0
HFD2_k127_3533134_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000002212 272.0
HFD2_k127_3533134_6 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000009244 203.0
HFD2_k127_3533134_7 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000000000000000000000000000000000004629 172.0
HFD2_k127_3533134_8 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000000000000000000000000000000003208 148.0
HFD2_k127_3533134_9 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000007204 138.0
HFD2_k127_3539103_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 3.374e-215 683.0
HFD2_k127_3539103_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 294.0
HFD2_k127_3539103_2 PFAM Tetratricopeptide repeat - - - 0.0005888 46.0
HFD2_k127_3574443_0 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 454.0
HFD2_k127_3574443_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005773,GO:0005774,GO:0006950,GO:0006970,GO:0006995,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009267,GO:0009268,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010446,GO:0016020,GO:0016491,GO:0016638,GO:0016639,GO:0017076,GO:0030554,GO:0031090,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043562,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0046686,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0051716,GO:0055114,GO:0071496,GO:0097159,GO:0097367,GO:0098588,GO:0098805,GO:1901265,GO:1901363 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 447.0
HFD2_k127_3574443_2 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 340.0
HFD2_k127_3574443_3 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006188 278.0
HFD2_k127_3574443_4 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000007118 231.0
HFD2_k127_3574443_5 - - - - 0.00000000000000000000002393 108.0
HFD2_k127_3601297_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 384.0
HFD2_k127_3601297_1 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000179 278.0
HFD2_k127_3601297_2 Belongs to the UPF0109 family K06960 - - 0.0000000000000000000000000000001682 125.0
HFD2_k127_3601297_3 SAM-dependent RNA methyltransferase - - - 0.000000000000000000000000000002699 122.0
HFD2_k127_3601297_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000003363 128.0
HFD2_k127_3601297_5 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000007769 114.0
HFD2_k127_3611779_0 Acyl-CoA synthetase (NDP forming) K09181 - - 1.149e-234 745.0
HFD2_k127_3611779_1 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 364.0
HFD2_k127_3611779_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 345.0
HFD2_k127_3611779_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 307.0
HFD2_k127_3611779_4 DRTGG domain K13788 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 303.0
HFD2_k127_3611779_5 response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 307.0
HFD2_k127_3611779_6 Response regulator receiver domain K03413 - - 0.00000000000000000000000000000000000000000000005654 171.0
HFD2_k127_3611779_7 HEAT repeat - - - 0.0000000000000000000000000000006254 135.0
HFD2_k127_3611779_8 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000000004224 124.0
HFD2_k127_3623343_0 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000001113 222.0
HFD2_k127_3623343_1 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000003654 220.0
HFD2_k127_3623343_2 Lysin motif - - - 0.0000000000000000000000001034 118.0
HFD2_k127_3623343_3 - - - - 0.00000000000000000506 86.0
HFD2_k127_3623343_4 phosphate-selective porin O and P - - - 0.0000000000000006557 90.0
HFD2_k127_3623343_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000001683 71.0
HFD2_k127_3678630_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 580.0
HFD2_k127_3678630_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 543.0
HFD2_k127_3678630_2 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 398.0
HFD2_k127_3678630_3 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004596 274.0
HFD2_k127_3678630_4 Phosphomethylpyrimidine kinase K00868,K00941,K03147,K21219 GO:0008150,GO:0040007 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000003809 258.0
HFD2_k127_3678630_5 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000003492 245.0
HFD2_k127_3678630_6 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000001779 175.0
HFD2_k127_3678630_7 Bacterial regulatory protein, Fis family K02481 - - 0.0000000000000000000000002525 109.0
HFD2_k127_3678630_8 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000006317 96.0
HFD2_k127_3728402_0 oxidase, subunit K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 537.0
HFD2_k127_3728402_1 oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 357.0
HFD2_k127_3728402_2 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 337.0
HFD2_k127_3728402_3 S-layer homology domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002441 267.0
HFD2_k127_3728402_4 Phosphoesterase RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000005049 238.0
HFD2_k127_3728402_5 Psort location Cytoplasmic, score K19824 - - 0.00000000000000000000000000000000000000000000000000000000004732 208.0
HFD2_k127_3728402_6 Belongs to the Fur family K03711,K09825 - - 0.00000000000000000000000000000000000000000000003622 173.0
HFD2_k127_3755877_0 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000001444 150.0
HFD2_k127_3755877_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000000000000000000005575 143.0
HFD2_k127_3755877_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000001609 139.0
HFD2_k127_3860543_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 448.0
HFD2_k127_3860543_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K05551 - 2.3.1.235,2.3.1.260 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 421.0
HFD2_k127_3860543_10 NADPH-dependent FMN reductase - - - 0.00000000000000009916 89.0
HFD2_k127_3860543_11 Amidohydrolase K03392 - 4.1.1.45 0.000000001998 65.0
HFD2_k127_3860543_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000002118 61.0
HFD2_k127_3860543_13 Virulence activator alpha C-term - - - 0.000001334 57.0
HFD2_k127_3860543_14 - - - - 0.00000695 52.0
HFD2_k127_3860543_15 - - - - 0.0000197 50.0
HFD2_k127_3860543_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 301.0
HFD2_k127_3860543_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000876 272.0
HFD2_k127_3860543_4 peptidase U32 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007621 272.0
HFD2_k127_3860543_5 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002644 256.0
HFD2_k127_3860543_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000192 178.0
HFD2_k127_3860543_7 negative regulation of translational initiation K05554,K14670 - - 0.00000000000000000000000000000000009342 137.0
HFD2_k127_3860543_8 Domain of unknown function (DUF4115) - - - 0.0000000000000000005463 97.0
HFD2_k127_3860543_9 PFAM Tetratricopeptide repeat - - - 0.0000000000000000009744 95.0
HFD2_k127_386853_0 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000003952 222.0
HFD2_k127_386853_1 Response regulator receiver domain - - - 0.000000000000000005289 86.0
HFD2_k127_3939206_0 Anticodon-binding domain of tRNA K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 552.0
HFD2_k127_3939206_1 stage 0 sporulation protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001543 257.0
HFD2_k127_3939206_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000005027 176.0
HFD2_k127_3939206_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000001559 154.0
HFD2_k127_3952589_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 7.855e-296 922.0
HFD2_k127_3952589_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 484.0
HFD2_k127_3952589_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000003047 193.0
HFD2_k127_3952589_3 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000005109 149.0
HFD2_k127_3952589_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000001826 113.0
HFD2_k127_3952589_5 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000518 101.0
HFD2_k127_3952589_6 Predicted membrane protein (DUF2232) - - - 0.00000000000000000001182 103.0
HFD2_k127_3952589_7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000002486 81.0
HFD2_k127_3952589_8 - - - - 0.0000000001619 74.0
HFD2_k127_395844_0 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000009803 235.0
HFD2_k127_395844_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000004357 225.0
HFD2_k127_395844_2 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000001326 89.0
HFD2_k127_395844_3 O-Antigen ligase K02847,K13009 - - 0.000000000000000004087 99.0
HFD2_k127_3965034_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 2.817e-195 616.0
HFD2_k127_3965034_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 481.0
HFD2_k127_3965034_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 376.0
HFD2_k127_3965034_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 303.0
HFD2_k127_3965034_4 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 310.0
HFD2_k127_3965034_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 294.0
HFD2_k127_3965034_7 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000003879 162.0
HFD2_k127_3973854_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 561.0
HFD2_k127_3973854_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 345.0
HFD2_k127_3973854_2 PFAM iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000000001237 206.0
HFD2_k127_4052875_0 Flavoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 366.0
HFD2_k127_4052875_1 proteolysis - - - 0.000000000000000000000000000009894 136.0
HFD2_k127_4052875_2 - - - - 0.0000002199 52.0
HFD2_k127_4092340_0 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002319 281.0
HFD2_k127_4092340_1 Protein of unknown function (DUF1698) - - - 0.000000000000000000000000000000000000000000000005865 184.0
HFD2_k127_4092340_2 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000000001661 174.0
HFD2_k127_4092340_3 Methyltransferase domain - - - 0.0000000000000000000000000000001046 135.0
HFD2_k127_4094976_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008165 283.0
HFD2_k127_4094976_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000001437 229.0
HFD2_k127_4094976_10 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000005278 66.0
HFD2_k127_4094976_2 CHASE K02488,K21009 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000002419 208.0
HFD2_k127_4094976_3 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000002308 185.0
HFD2_k127_4094976_4 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000003566 179.0
HFD2_k127_4094976_5 SurA N-terminal domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000001053 184.0
HFD2_k127_4094976_6 peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.00000000000000000000000000000000000000000000205 177.0
HFD2_k127_4094976_8 PFAM Tetratricopeptide repeat - - - 0.000000000000000000007049 104.0
HFD2_k127_4130426_0 TIGRFAM formate dehydrogenase, alpha subunit K00336,K05299 - 1.17.1.10,1.6.5.3 2.926e-215 698.0
HFD2_k127_4130426_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 507.0
HFD2_k127_4130426_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 499.0
HFD2_k127_4130426_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001212 233.0
HFD2_k127_4130426_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000006494 198.0
HFD2_k127_4130426_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000007167 181.0
HFD2_k127_4130426_6 NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000002192 148.0
HFD2_k127_4134631_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 2.145e-194 612.0
HFD2_k127_4134631_1 PFAM Na Picotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 408.0
HFD2_k127_4134631_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 301.0
HFD2_k127_4134631_3 6,7-dimethyl-8-ribityllumazine synthase K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000008265 219.0
HFD2_k127_4165833_0 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000006839 232.0
HFD2_k127_4165833_1 Signal transduction histidine kinase K07777 - 2.7.13.3 0.00000000000000000000000000000000000000007647 171.0
HFD2_k127_4196360_0 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 342.0
HFD2_k127_4196360_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000006198 134.0
HFD2_k127_4196360_2 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000005612 100.0
HFD2_k127_4226728_0 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 524.0
HFD2_k127_4226728_1 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 310.0
HFD2_k127_4226728_2 - - - - 0.0000000000000000357 86.0
HFD2_k127_42604_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 589.0
HFD2_k127_42604_1 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 378.0
HFD2_k127_42604_2 COG0006 Xaa-Pro aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 327.0
HFD2_k127_42604_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006054 273.0
HFD2_k127_42604_4 TIGRFAM phosphomethylpyrimidine kinase K00941,K14153 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000003991 220.0
HFD2_k127_42604_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000001374 197.0
HFD2_k127_42604_6 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000006485 159.0
HFD2_k127_4265885_0 metal-dependent hydrolase with the TIM-barrel fold - - - 1.223e-284 884.0
HFD2_k127_4265885_1 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 558.0
HFD2_k127_4265885_2 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 306.0
HFD2_k127_4265885_3 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 295.0
HFD2_k127_4265885_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002571 239.0
HFD2_k127_4265885_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000385 229.0
HFD2_k127_4265885_6 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.00000000000000000000000000000000000000005041 153.0
HFD2_k127_4265885_7 Antibiotic biosynthesis monooxygenase K09932 - - 0.00000000000000000000000000000000000002396 164.0
HFD2_k127_428796_0 Amino acid permease - - - 1.311e-258 812.0
HFD2_k127_428796_1 Amino acid permease - - - 7.783e-246 775.0
HFD2_k127_428796_2 Putative member of DMT superfamily (DUF486) - - - 0.0000000000000000000000000000000000000000000003431 169.0
HFD2_k127_4329582_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 612.0
HFD2_k127_4329582_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 441.0
HFD2_k127_4329582_2 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 291.0
HFD2_k127_4329582_3 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000001007 150.0
HFD2_k127_4329582_4 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.00000000000000000000000000000000000008042 152.0
HFD2_k127_4406635_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.926e-212 670.0
HFD2_k127_4406635_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.0000000000000000000000000000000000000000000000004683 183.0
HFD2_k127_4406635_2 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.0000000000000003027 84.0
HFD2_k127_442217_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1769.0
HFD2_k127_442217_1 Cache domain - - - 5.954e-220 697.0
HFD2_k127_442217_10 proton-transporting ATP synthase activity, rotational mechanism K02115 - - 0.0000000000000000000000000001963 125.0
HFD2_k127_442217_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000003797 95.0
HFD2_k127_442217_12 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000003874 78.0
HFD2_k127_442217_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000588 68.0
HFD2_k127_442217_14 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000002268 61.0
HFD2_k127_442217_2 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 6.711e-197 623.0
HFD2_k127_442217_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008809 537.0
HFD2_k127_442217_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 522.0
HFD2_k127_442217_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008817 515.0
HFD2_k127_442217_6 Transcriptional regulator K18136 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003348 268.0
HFD2_k127_442217_7 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000004138 227.0
HFD2_k127_442217_8 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000004352 198.0
HFD2_k127_442217_9 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000003027 195.0
HFD2_k127_443885_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 608.0
HFD2_k127_443885_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 607.0
HFD2_k127_443885_10 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008118 306.0
HFD2_k127_443885_11 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
HFD2_k127_443885_12 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000003031 226.0
HFD2_k127_443885_13 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000001352 218.0
HFD2_k127_443885_14 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000004486 139.0
HFD2_k127_443885_15 Radical SAM domain protein - - - 0.00000000000000000000000001431 112.0
HFD2_k127_443885_16 Evidence 5 No homology to any previously reported sequences - - - 0.000000003494 63.0
HFD2_k127_443885_17 Cell division protein FtsQ K03589 - - 0.00000003335 64.0
HFD2_k127_443885_18 Tubulin/FtsZ family, GTPase domain - - - 0.00003516 54.0
HFD2_k127_443885_2 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 494.0
HFD2_k127_443885_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 458.0
HFD2_k127_443885_4 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 464.0
HFD2_k127_443885_5 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 425.0
HFD2_k127_443885_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 412.0
HFD2_k127_443885_7 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 363.0
HFD2_k127_443885_8 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 342.0
HFD2_k127_443885_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004091 332.0
HFD2_k127_4482326_0 phosphorelay signal transduction system K02584,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 475.0
HFD2_k127_4482326_1 cell redox homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002144 272.0
HFD2_k127_4482326_2 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000009058 235.0
HFD2_k127_4482326_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000001406 93.0
HFD2_k127_4487026_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 8.259e-205 647.0
HFD2_k127_4487026_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 6.328e-199 631.0
HFD2_k127_4487026_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008574 302.0
HFD2_k127_4487026_3 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000001068 182.0
HFD2_k127_4487026_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000004831 124.0
HFD2_k127_4487026_5 Protein conserved in bacteria - - - 0.00000000000000000000000008619 110.0
HFD2_k127_4518044_0 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000004725 226.0
HFD2_k127_4518044_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000004783 222.0
HFD2_k127_4518044_2 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000001069 171.0
HFD2_k127_4539604_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.006e-224 711.0
HFD2_k127_4539604_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 545.0
HFD2_k127_4539604_2 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 491.0
HFD2_k127_4539604_3 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 376.0
HFD2_k127_4539604_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074,K12257 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 338.0
HFD2_k127_4539604_5 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002422 259.0
HFD2_k127_4539604_6 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001849 244.0
HFD2_k127_4539604_7 RNA recognition motif - - - 0.0000000000000000000000000000003381 126.0
HFD2_k127_4539604_8 - - - - 0.0000000000000002119 82.0
HFD2_k127_457605_0 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 345.0
HFD2_k127_457605_1 Ion transport 2 domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000004509 207.0
HFD2_k127_457605_2 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000005534 130.0
HFD2_k127_457605_3 Transcriptional regulator, MerR family - - - 0.000000000000000000000000000008087 123.0
HFD2_k127_4637730_0 TIGRFAM cysteine desulfurase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 428.0
HFD2_k127_4637730_1 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 366.0
HFD2_k127_4637730_2 CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein) - - - 0.00000000000000000000000000000000000000000000000000000003134 206.0
HFD2_k127_4637730_3 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000001775 134.0
HFD2_k127_4637730_5 peptidyl-tyrosine sulfation - - - 0.0006163 49.0
HFD2_k127_4673231_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 483.0
HFD2_k127_4673231_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 350.0
HFD2_k127_4673231_2 PFAM cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000008265 219.0
HFD2_k127_4785200_0 transporter antisigma-factor antagonist STAS K03321 - - 2.575e-226 715.0
HFD2_k127_4785200_1 cell redox homeostasis - - - 3.901e-210 662.0
HFD2_k127_4785200_10 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000009744 241.0
HFD2_k127_4785200_11 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
HFD2_k127_4785200_12 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000001208 162.0
HFD2_k127_4785200_13 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000002141 149.0
HFD2_k127_4785200_14 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000002731 101.0
HFD2_k127_4785200_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 611.0
HFD2_k127_4785200_3 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009249 418.0
HFD2_k127_4785200_4 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 402.0
HFD2_k127_4785200_5 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 330.0
HFD2_k127_4785200_6 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 309.0
HFD2_k127_4785200_7 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 306.0
HFD2_k127_4785200_8 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 296.0
HFD2_k127_4785200_9 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000006003 251.0
HFD2_k127_4789098_0 Belongs to the DegT DnrJ EryC1 family K12452 - 1.17.1.1 3.021e-241 750.0
HFD2_k127_4789098_1 PFAM NAD-dependent epimerase dehydratase K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 552.0
HFD2_k127_4789098_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000008313 160.0
HFD2_k127_4789098_3 Nucleotidyl transferase K00978 - 2.7.7.33 0.000000000000000008923 83.0
HFD2_k127_4851099_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 447.0
HFD2_k127_4851099_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009096 298.0
HFD2_k127_4851099_2 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 293.0
HFD2_k127_4851099_3 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005314 274.0
HFD2_k127_4851099_4 outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000408 203.0
HFD2_k127_4851099_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000001421 198.0
HFD2_k127_4851099_6 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000008377 113.0
HFD2_k127_4851099_7 Bacterial regulatory proteins, tetR family K13770 - - 0.000000000000000000811 94.0
HFD2_k127_4851099_8 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.00000000000000000207 90.0
HFD2_k127_4851099_9 Cytochrome c - - - 0.000001139 62.0
HFD2_k127_4854820_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 560.0
HFD2_k127_4854820_1 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009308 246.0
HFD2_k127_4854820_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000002046 145.0
HFD2_k127_4854820_3 - - - - 0.0000001391 55.0
HFD2_k127_4868748_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.0 1311.0
HFD2_k127_4868748_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 409.0
HFD2_k127_4868748_2 PFAM Cytochrome b5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005505 290.0
HFD2_k127_4868748_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000004576 206.0
HFD2_k127_4868748_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000582 198.0
HFD2_k127_4868748_5 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000008317 144.0
HFD2_k127_4868748_6 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000002742 102.0
HFD2_k127_4868748_7 Methyltransferase FkbM domain - - - 0.000000000000000001926 96.0
HFD2_k127_4868748_8 Domain of unknown function (DUF4911) - - - 0.0000000004727 63.0
HFD2_k127_4902113_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007655 301.0
HFD2_k127_4902113_1 Transport permease protein K01992 - - 0.00000000000000000007515 91.0
HFD2_k127_4902113_2 ThiS-like ubiquitin K03148 - 2.7.7.73 0.000000007478 58.0
HFD2_k127_4912395_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 6.879e-218 691.0
HFD2_k127_4912395_1 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 503.0
HFD2_k127_4912395_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 478.0
HFD2_k127_4912395_3 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000002404 232.0
HFD2_k127_4912395_4 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000002014 193.0
HFD2_k127_4912395_5 Isochorismatase family K08281 - 3.5.1.19 0.00000000000000000000000000000000000000000000000000001106 194.0
HFD2_k127_4912395_6 Protein of unknown function (DUF1318) - - - 0.0000000000000000000000000000000000001064 149.0
HFD2_k127_4912395_7 Thiamine-binding protein - - - 0.0000000000000000000000000000004859 126.0
HFD2_k127_4964215_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 7.099e-299 927.0
HFD2_k127_4964215_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 542.0
HFD2_k127_4964215_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 541.0
HFD2_k127_4964215_3 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 526.0
HFD2_k127_4964215_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 475.0
HFD2_k127_4964215_5 e3 binding domain K00627,K00658 - 2.3.1.12,2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 351.0
HFD2_k127_4964215_6 radical SAM domain protein - - - 0.000000000000000000006683 96.0
HFD2_k127_4964215_7 Phosphopantetheine attachment site - - - 0.00000000000000000008496 91.0
HFD2_k127_497414_0 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001345 294.0
HFD2_k127_497414_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000006647 233.0
HFD2_k127_4997186_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 476.0
HFD2_k127_4997186_1 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 301.0
HFD2_k127_4997186_2 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000004959 192.0
HFD2_k127_4997186_3 Thiamine-binding protein - - - 0.00000000000000000000000000006585 121.0
HFD2_k127_4997186_4 protein involved in outer membrane biogenesis K07289 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.000009668 57.0
HFD2_k127_5001346_0 Belongs to the carbamoyltransferase HypF family K04656 - - 4.662e-232 742.0
HFD2_k127_5001346_1 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K00533,K05922,K06281 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 568.0
HFD2_k127_5001346_2 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 408.0
HFD2_k127_5001346_3 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004594 292.0
HFD2_k127_5001346_4 hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000000000003346 159.0
HFD2_k127_5001346_5 Prokaryotic cytochrome b561 K03620 - - 0.0000000000000000000000000000309 125.0
HFD2_k127_5001346_6 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000002969 117.0
HFD2_k127_5033398_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 563.0
HFD2_k127_5033398_1 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 449.0
HFD2_k127_5033398_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 430.0
HFD2_k127_5033398_3 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 403.0
HFD2_k127_5033398_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 394.0
HFD2_k127_5033398_5 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 312.0
HFD2_k127_5033398_6 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000006061 194.0
HFD2_k127_5033398_7 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000004858 183.0
HFD2_k127_5033398_8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000003696 91.0
HFD2_k127_5119636_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 2.979e-202 646.0
HFD2_k127_5119636_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 523.0
HFD2_k127_5119636_10 CAAX protease self-immunity K07052 - - 0.00000000007479 70.0
HFD2_k127_5119636_2 Trypsin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 409.0
HFD2_k127_5119636_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 363.0
HFD2_k127_5119636_4 Conserved protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005213 347.0
HFD2_k127_5119636_5 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000001843 256.0
HFD2_k127_5119636_6 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001923 244.0
HFD2_k127_5119636_7 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000006771 169.0
HFD2_k127_5119636_8 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.00000000000000000000000000000000000000005595 160.0
HFD2_k127_5119636_9 Protein of unknown function (DUF721) - - - 0.000000000000007746 82.0
HFD2_k127_5132297_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1135.0
HFD2_k127_5132297_1 Major facilitator Superfamily - - - 0.0000000000000000000000721 99.0
HFD2_k127_5134611_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 8.15e-320 993.0
HFD2_k127_5134611_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 7.304e-274 852.0
HFD2_k127_5134611_10 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000001573 126.0
HFD2_k127_5134611_11 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000000001909 118.0
HFD2_k127_5134611_12 Protein of unknown function (DUF465) K09794 - - 0.00000000007685 65.0
HFD2_k127_5134611_2 Dehydratase family K01687 - 4.2.1.9 3.21e-248 777.0
HFD2_k127_5134611_3 Peptidase family U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 559.0
HFD2_k127_5134611_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 479.0
HFD2_k127_5134611_5 Uncharacterized protein conserved in bacteria (DUF2087) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005662 265.0
HFD2_k127_5134611_6 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000002403 243.0
HFD2_k127_5134611_7 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000001595 208.0
HFD2_k127_5134611_8 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000008918 188.0
HFD2_k127_5134611_9 negative regulation of translational initiation K05554,K15885 - - 0.000000000000000000000000000000000000002665 151.0
HFD2_k127_5137198_0 Permease YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 290.0
HFD2_k127_5137198_1 PFAM permease YjgP YjgQ family protein K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001265 273.0
HFD2_k127_5137198_3 - - - - 0.00000000000000000000006477 100.0
HFD2_k127_5149369_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.484e-219 691.0
HFD2_k127_5149369_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000002019 122.0
HFD2_k127_5159008_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1181.0
HFD2_k127_5159008_1 HELICc2 K03722 - 3.6.4.12 2.478e-241 771.0
HFD2_k127_5159008_10 PFAM OsmC family protein K04063 - - 0.0000000000000000000000000000000000000000000000000000005053 195.0
HFD2_k127_5159008_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000001407 158.0
HFD2_k127_5159008_12 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000001313 136.0
HFD2_k127_5159008_13 helix_turn_helix gluconate operon transcriptional repressor K03710 - - 0.0000000000000000000000000001571 125.0
HFD2_k127_5159008_14 PFAM Colicin V production K03558 - - 0.00000000007852 70.0
HFD2_k127_5159008_15 Putative zinc- or iron-chelating domain - - - 0.00000000009544 70.0
HFD2_k127_5159008_16 - - - - 0.00000265 59.0
HFD2_k127_5159008_2 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 419.0
HFD2_k127_5159008_3 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 413.0
HFD2_k127_5159008_4 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009783 402.0
HFD2_k127_5159008_5 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 404.0
HFD2_k127_5159008_6 PFAM Dehydrogenase, E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 376.0
HFD2_k127_5159008_7 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 380.0
HFD2_k127_5159008_8 Glycosyl hydrolases family 15 K07190 - - 0.000000000000000000000000000000000000000000000000000000000000000007259 243.0
HFD2_k127_5159008_9 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000009085 223.0
HFD2_k127_5168198_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.848e-241 760.0
HFD2_k127_5168198_1 PFAM Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000003101 211.0
HFD2_k127_5168198_2 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000000000000000000009507 173.0
HFD2_k127_5168198_3 Binds the 23S rRNA K02909 - - 0.000000000000000000000000002431 113.0
HFD2_k127_5178970_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 592.0
HFD2_k127_5178970_1 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 484.0
HFD2_k127_5178970_2 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 459.0
HFD2_k127_5178970_3 Polysaccharide biosynthesis protein K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001363 277.0
HFD2_k127_5178970_4 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000002429 242.0
HFD2_k127_5178970_5 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000004088 151.0
HFD2_k127_5178970_6 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000003101 57.0
HFD2_k127_5258005_0 Eco57I restriction-modification methylase - - - 1.83e-270 861.0
HFD2_k127_5258005_1 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 454.0
HFD2_k127_5258005_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000002723 232.0
HFD2_k127_5258005_3 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000006419 74.0
HFD2_k127_527223_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.676e-277 866.0
HFD2_k127_527223_1 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 481.0
HFD2_k127_527223_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000005947 211.0
HFD2_k127_527223_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000000001007 170.0
HFD2_k127_527223_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000003657 118.0
HFD2_k127_527223_5 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000005695 70.0
HFD2_k127_5289527_0 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1163.0
HFD2_k127_5289527_1 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000006646 199.0
HFD2_k127_5289527_2 methyl-accepting chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000002769 182.0
HFD2_k127_5289527_3 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000006976 83.0
HFD2_k127_5289527_4 Lipopolysaccharide-assembly - - - 0.0000001154 60.0
HFD2_k127_5306381_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 293.0
HFD2_k127_5306381_1 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 292.0
HFD2_k127_5306381_2 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000005609 239.0
HFD2_k127_5306381_3 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000000001115 131.0
HFD2_k127_533593_0 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 486.0
HFD2_k127_533593_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000005906 219.0
HFD2_k127_533593_2 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000003734 142.0
HFD2_k127_5490806_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 384.0
HFD2_k127_5490806_1 Belongs to the RuBisCO large chain family K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 353.0
HFD2_k127_5490806_10 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.00000001202 59.0
HFD2_k127_5490806_2 PFAM PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001213 256.0
HFD2_k127_5490806_3 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000003976 234.0
HFD2_k127_5490806_4 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.0000000000000000000000000000000000000000000000000317 193.0
HFD2_k127_5490806_5 Chromate transporter K07240 - - 0.0000000000000000000000000000000001059 143.0
HFD2_k127_5490806_6 Chromate transporter K07240 - - 0.0000000000000000000000000000008117 130.0
HFD2_k127_5490806_7 belongs to the thioredoxin family K03671,K03672 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.8 0.00000000000000000000000000006755 121.0
HFD2_k127_5490806_8 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.0000000000000000000000000001304 128.0
HFD2_k127_5490806_9 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000008118 79.0
HFD2_k127_5516428_0 PFAM DNA polymerase beta domain protein region K07076 - - 0.0000000000000003489 85.0
HFD2_k127_5516428_1 Unextendable partial coding region - - - 0.00000000000001207 74.0
HFD2_k127_5516428_2 Protein of unknown function DUF86 - - - 0.0000000000001163 77.0
HFD2_k127_5516428_3 - - - - 0.0000003597 53.0
HFD2_k127_559479_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.713e-208 657.0
HFD2_k127_559479_1 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 371.0
HFD2_k127_559479_2 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 364.0
HFD2_k127_559479_3 Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 351.0
HFD2_k127_559479_4 methylated-DNA- protein -cysteine S-methyltransferase K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 294.0
HFD2_k127_5692059_0 MltA specific insert domain K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 312.0
HFD2_k127_5692059_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000002043 227.0
HFD2_k127_5692059_2 HD domain - - - 0.00000000000000000000008403 108.0
HFD2_k127_5754954_0 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 402.0
HFD2_k127_5754954_1 metallopeptidase activity K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 330.0
HFD2_k127_5754954_2 N-terminal domain of unknown function (DUF4140) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 307.0
HFD2_k127_5754954_3 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein - - - 0.00000000002517 75.0
HFD2_k127_5782292_0 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000008772 216.0
HFD2_k127_5782292_1 Ribonuclease H K03469 - 3.1.26.4 0.000000000000000000000000000000000002929 144.0
HFD2_k127_5782292_2 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000001632 109.0
HFD2_k127_5782292_3 capsule polysaccharide biosynthetic process K13687 GO:0008150,GO:0040007 - 0.0001228 55.0
HFD2_k127_5789543_0 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002266 281.0
HFD2_k127_5789543_1 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003154 262.0
HFD2_k127_5789543_3 Dinitrogenase iron-molybdenum cofactor - - - 0.00000000000004268 77.0
HFD2_k127_5789543_4 Protein of unknown function (DUF3373) - - - 0.00000006728 58.0
HFD2_k127_57956_0 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 396.0
HFD2_k127_57956_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000009654 236.0
HFD2_k127_57956_2 PFAM DoxX K15977 - - 0.0000000000000000000000000000000000000000002717 162.0
HFD2_k127_57956_3 amine dehydrogenase activity - - - 0.000000000000000000000000000000000004397 141.0
HFD2_k127_5800312_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 4.003e-278 865.0
HFD2_k127_5800312_1 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 1.491e-239 751.0
HFD2_k127_5800312_2 NAD(P)H dehydrogenase (quinone) K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 295.0
HFD2_k127_5800312_3 GNAT family acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001445 230.0
HFD2_k127_5806219_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 1.936e-231 732.0
HFD2_k127_5806219_1 NAD dependent epimerase dehydratase family K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 383.0
HFD2_k127_5806219_2 Methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003257 250.0
HFD2_k127_5806219_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000009535 201.0
HFD2_k127_5806219_4 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000006452 121.0
HFD2_k127_5808965_0 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 469.0
HFD2_k127_5808965_1 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 376.0
HFD2_k127_5808965_2 Methylenetetrahydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 363.0
HFD2_k127_5808965_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 348.0
HFD2_k127_5808965_4 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 322.0
HFD2_k127_5808965_5 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 312.0
HFD2_k127_5808965_6 Domain of unknown function (DUF2520) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002158 280.0
HFD2_k127_5808965_7 AAA domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002538 272.0
HFD2_k127_5808965_8 electron transfer activity K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000000289 229.0
HFD2_k127_5808965_9 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000001221 190.0
HFD2_k127_5811524_0 Aldehyde dehydrogenase family K22187 - - 7.667e-196 621.0
HFD2_k127_5811524_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007715 565.0
HFD2_k127_5811524_2 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 536.0
HFD2_k127_5811524_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 487.0
HFD2_k127_5811524_4 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 365.0
HFD2_k127_5811524_5 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006036 276.0
HFD2_k127_5811524_6 O-methyltransferase, family 2 - - - 0.00000000000000000000000000000000000000000002593 174.0
HFD2_k127_5811524_7 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.000000000000000000000000000000000000000004155 156.0
HFD2_k127_5811524_8 Nucleotidyltransferase domain - - - 0.0000000000000000000000000007661 115.0
HFD2_k127_5823035_0 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 411.0
HFD2_k127_5823035_1 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000941 224.0
HFD2_k127_5823035_2 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000003498 150.0
HFD2_k127_5823035_3 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000001046 139.0
HFD2_k127_5882016_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 321.0
HFD2_k127_5882016_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000001302 208.0
HFD2_k127_5882016_2 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.0000000000000000000000000000000002512 136.0
HFD2_k127_5882016_3 Rieske [2Fe-2S] domain K02636 - 1.10.9.1 0.000000000000000001431 91.0
HFD2_k127_589048_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.689e-209 657.0
HFD2_k127_589048_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 571.0
HFD2_k127_589048_10 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000127 162.0
HFD2_k127_589048_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000003257 85.0
HFD2_k127_589048_12 cell cycle K05589,K12065,K13052 - - 0.0000000002065 65.0
HFD2_k127_589048_2 Glycosyl hydrolase family 57 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 489.0
HFD2_k127_589048_3 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 464.0
HFD2_k127_589048_4 pyridine nucleotide-disulphide oxidoreductase dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 419.0
HFD2_k127_589048_5 PFAM ABC transporter related K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 314.0
HFD2_k127_589048_6 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 299.0
HFD2_k127_589048_7 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005669 272.0
HFD2_k127_589048_8 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001865 276.0
HFD2_k127_589048_9 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000000000000000000000000000000005881 194.0
HFD2_k127_5968374_0 B12 binding domain - - - 0.000000000000000000000000000000005709 136.0
HFD2_k127_5968374_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000002727 135.0
HFD2_k127_5996084_0 phosphate ion binding K02040 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 389.0
HFD2_k127_5996084_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 351.0
HFD2_k127_5996084_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008027 325.0
HFD2_k127_5996084_3 TIGRFAM phosphate ABC transporter K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007683 282.0
HFD2_k127_5996084_4 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001588 268.0
HFD2_k127_5996084_5 PFAM EamA-like transporter family - - - 0.000000000000000000004026 104.0
HFD2_k127_5996084_6 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.0000005564 55.0
HFD2_k127_6016918_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000003166 204.0
HFD2_k127_6016918_1 Cache domain - - - 0.00000000000000001773 82.0
HFD2_k127_6016918_2 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000004943 87.0
HFD2_k127_6016918_3 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000009479 62.0
HFD2_k127_6070325_0 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 445.0
HFD2_k127_6070325_1 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 399.0
HFD2_k127_6070325_2 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 346.0
HFD2_k127_6070325_3 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 336.0
HFD2_k127_6070325_4 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000004406 224.0
HFD2_k127_6070325_5 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000001766 177.0
HFD2_k127_6070325_6 protein flavinylation K03734 - 2.7.1.180 0.0000000000000000000000000003551 117.0
HFD2_k127_6070930_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 357.0
HFD2_k127_6070930_1 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 315.0
HFD2_k127_6070930_2 extracellular polysaccharide biosynthetic process K00568,K03561,K07011,K20444 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000002903 139.0
HFD2_k127_6070930_3 Bacterial membrane protein YfhO - - - 0.000000000000000000002885 100.0
HFD2_k127_6070930_4 Membrane - - - 0.000000000002579 79.0
HFD2_k127_6082310_0 Pyridine nucleotide-disulphide oxidoreductase K15022 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.17.1.10 3.785e-243 766.0
HFD2_k127_6082310_1 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 477.0
HFD2_k127_6082310_10 sulfur carrier activity - - - 0.0000000000000000002669 90.0
HFD2_k127_6082310_2 AMMECR1 K06990,K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 362.0
HFD2_k127_6082310_3 Evidence 4 Homologs of previously reported genes of K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004006 261.0
HFD2_k127_6082310_4 Tetrapyrrole (Corrin/Porphyrin) Methylases K01719,K01749,K02303,K13542,K13543 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000008218 254.0
HFD2_k127_6082310_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000008157 237.0
HFD2_k127_6082310_6 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000002722 190.0
HFD2_k127_6082310_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000002352 117.0
HFD2_k127_6082310_8 DsrC like protein K11179 - - 0.0000000000000000000000000211 112.0
HFD2_k127_6082310_9 OsmC-like protein K07397 - - 0.0000000000000000000000002073 111.0
HFD2_k127_6114501_0 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 473.0
HFD2_k127_6114501_1 4 iron, 4 sulfur cluster binding K02574 - - 0.0000000000000000000000000000000000000000000000000000142 199.0
HFD2_k127_6114501_2 MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000007915 187.0
HFD2_k127_6114501_3 TonB C terminal K03832 - - 0.0000000000000000000002155 106.0
HFD2_k127_6114501_4 biopolymer transport protein K03559 - - 0.0000000000000000000007818 99.0
HFD2_k127_6114501_5 COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component K02003 - - 0.0001392 51.0
HFD2_k127_6146734_0 Elongation factor Tu domain 2 K02355 - - 6.631e-226 715.0
HFD2_k127_6146734_1 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 447.0
HFD2_k127_6146734_10 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000005434 207.0
HFD2_k127_6146734_11 Cobalamin-5-phosphate synthase K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000003409 181.0
HFD2_k127_6146734_12 PFAM Cobinamide kinase cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000006583 164.0
HFD2_k127_6146734_13 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000007428 155.0
HFD2_k127_6146734_14 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000002231 125.0
HFD2_k127_6146734_15 regulatory protein, MerR - - - 0.000000000000000000000000526 108.0
HFD2_k127_6146734_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 412.0
HFD2_k127_6146734_3 Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L- methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by K22466 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 391.0
HFD2_k127_6146734_4 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 310.0
HFD2_k127_6146734_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009328 291.0
HFD2_k127_6146734_6 FtsZ-dependent cytokinesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002587 264.0
HFD2_k127_6146734_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000001385 263.0
HFD2_k127_6146734_9 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000003411 215.0
HFD2_k127_6157228_0 Conserved carboxylase domain K01958 - 6.4.1.1 0.0 1065.0
HFD2_k127_6157228_1 acetyl-CoA carboxylase, biotin carboxylase K01965 - 6.4.1.3 1.801e-234 733.0
HFD2_k127_6157228_2 IMG reference gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 407.0
HFD2_k127_6157228_3 IMG reference gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 326.0
HFD2_k127_6157228_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000004095 233.0
HFD2_k127_623070_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 289.0
HFD2_k127_623070_1 Signal transduction histidine kinase, nitrogen specific, NtrB K07708,K10942 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003513 269.0
HFD2_k127_623070_2 thiolester hydrolase activity K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000004188 179.0
HFD2_k127_623070_3 glycolate biosynthetic process K01560,K07025 - 3.8.1.2 0.0000000000000000000000000000000000000007007 158.0
HFD2_k127_623070_4 PilZ domain - - - 0.00000000000000000000000719 109.0
HFD2_k127_623070_5 - - - - 0.000000000000000009357 86.0
HFD2_k127_623070_6 YHS domain - - - 0.0000001163 55.0
HFD2_k127_623070_7 Gaf domain - - - 0.000001796 54.0
HFD2_k127_623070_8 PFAM VanZ family protein - - - 0.000008735 54.0
HFD2_k127_6245763_0 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002368 280.0
HFD2_k127_6245763_1 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001303 263.0
HFD2_k127_6245763_2 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000000000000000000000000000000000000000000000000000000009581 228.0
HFD2_k127_6245763_3 signal sequence binding K07152 - - 0.000000000000000000000000000000000000000000000000001486 193.0
HFD2_k127_6245763_4 Von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000004756 148.0
HFD2_k127_6245763_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.000000000000003214 79.0
HFD2_k127_6245763_6 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000006084 84.0
HFD2_k127_6269096_0 B12 binding domain K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 385.0
HFD2_k127_6269096_1 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 380.0
HFD2_k127_6269096_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 338.0
HFD2_k127_6269096_3 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008403 308.0
HFD2_k127_6269096_4 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000722 253.0
HFD2_k127_6269096_5 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000001677 207.0
HFD2_k127_6269096_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000003651 191.0
HFD2_k127_6269096_7 Rhodanese Homology Domain - - - 0.00000000000000000004264 93.0
HFD2_k127_6269096_8 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000002745 87.0
HFD2_k127_6293061_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.533e-259 828.0
HFD2_k127_6293061_1 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 429.0
HFD2_k127_6293061_2 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000003311 266.0
HFD2_k127_6293061_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000002544 236.0
HFD2_k127_6293061_4 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000003759 151.0
HFD2_k127_6293061_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000006036 134.0
HFD2_k127_6293061_6 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000001351 124.0
HFD2_k127_6293061_7 Protein of unknown function (DUF503) K09764 - - 0.000000000000000000000000004636 112.0
HFD2_k127_6293061_8 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.000000000000000000000001083 105.0
HFD2_k127_6293061_9 ribosomal protein L7Ae L30e S12e Gadd45 K07742 - - 0.0000000000000000000007719 102.0
HFD2_k127_6347841_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 409.0
HFD2_k127_6347841_1 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000001207 179.0
HFD2_k127_6347841_2 monooxygenase activity - - - 0.000000000000000000000000000000004291 132.0
HFD2_k127_6347841_3 alginic acid biosynthetic process - - - 0.00000000000000000000000000000002359 141.0
HFD2_k127_6347841_4 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000166 108.0
HFD2_k127_6347841_5 alginic acid biosynthetic process - - - 0.0000000001332 66.0
HFD2_k127_6347841_6 O-Antigen ligase - - - 0.00002192 53.0
HFD2_k127_6362_0 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 562.0
HFD2_k127_6362_1 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 375.0
HFD2_k127_6362_2 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 328.0
HFD2_k127_6362_3 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000004821 198.0
HFD2_k127_6362_4 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000003269 72.0
HFD2_k127_6362_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K01406 - 3.4.24.40 0.000000005664 71.0
HFD2_k127_6362_6 Ami_2 - - - 0.0000002017 66.0
HFD2_k127_6362_7 Glycosyltransferase 36 associated - - - 0.000695 46.0
HFD2_k127_6367008_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 482.0
HFD2_k127_6367008_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 379.0
HFD2_k127_6367008_2 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 295.0
HFD2_k127_6367008_3 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000007599 162.0
HFD2_k127_6367008_4 PFAM Tetratricopeptide repeat - - - 0.00000000000002811 83.0
HFD2_k127_6408909_0 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 407.0
HFD2_k127_6408909_1 Elongator protein 3, MiaB family, Radical SAM K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 331.0
HFD2_k127_6408909_2 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001753 254.0
HFD2_k127_6408909_3 PFAM Binding-protein-dependent transport system inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000001342 239.0
HFD2_k127_6408909_4 ABC transporter K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000008462 238.0
HFD2_k127_6409929_0 Heat shock 70 kDa protein K04043 - - 2.631e-264 819.0
HFD2_k127_6409929_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 392.0
HFD2_k127_6409929_2 HrcA protein C terminal domain K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 338.0
HFD2_k127_6409929_3 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 325.0
HFD2_k127_6409929_4 ABC transporter K02003,K09814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000503 254.0
HFD2_k127_6409929_5 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000006022 238.0
HFD2_k127_6409929_6 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000001343 183.0
HFD2_k127_6409929_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.000000000000000000000000000000000002907 145.0
HFD2_k127_6432799_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 585.0
HFD2_k127_6432799_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 486.0
HFD2_k127_6432799_2 Haloacid dehalogenase-like hydrolase K20866 - 3.1.3.10 0.00000000000000000000000000000000007078 141.0
HFD2_k127_6449007_0 - - - - 0.000000000000000006466 91.0
HFD2_k127_6449007_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000001686 68.0
HFD2_k127_6449007_2 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0005997 43.0
HFD2_k127_6462911_0 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008363 266.0
HFD2_k127_6462911_1 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000001511 161.0
HFD2_k127_6462911_2 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000009023 144.0
HFD2_k127_6462911_3 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000000692 114.0
HFD2_k127_6462911_4 ATPases associated with a variety of cellular activities K02006 - - 0.00000000000000000000000004471 110.0
HFD2_k127_6462911_5 Phosphate-starvation-inducible E - - - 0.00000000007909 69.0
HFD2_k127_6462911_6 Cobalt transport protein K02008 - - 0.00001306 56.0
HFD2_k127_6524738_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 593.0
HFD2_k127_6524738_1 glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 515.0
HFD2_k127_6524738_2 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000003166 270.0
HFD2_k127_6524738_3 transmembrane transport - - - 0.0000000000000000000000000000001205 132.0
HFD2_k127_6524738_4 Thioredoxin-like K02199,K03671 - - 0.0000000000000000000007621 99.0
HFD2_k127_6528933_0 TIGRFAM Arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 415.0
HFD2_k127_6528933_1 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 353.0
HFD2_k127_6528933_2 Methylates ribosomal protein L11 K02687 - - 0.000000000000000000000000000000000000007652 156.0
HFD2_k127_6575327_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009236 617.0
HFD2_k127_6575327_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000001124 261.0
HFD2_k127_6575327_2 Formiminotransferase-cyclodeaminase - - - 0.000000000000000000000000000000000000000000609 166.0
HFD2_k127_6636991_0 Nickel-dependent hydrogenase K00436,K14126 - 1.12.1.2,1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 486.0
HFD2_k127_6636991_1 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 325.0
HFD2_k127_6636991_2 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003039 261.0
HFD2_k127_6636991_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000001139 242.0
HFD2_k127_6636991_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004414 226.0
HFD2_k127_6636991_5 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000009153 213.0
HFD2_k127_6636991_6 PFAM Cyclic nucleotide-binding domain - - - 0.00000000000003686 78.0
HFD2_k127_6649370_0 Biotin-protein ligase, N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000804 311.0
HFD2_k127_6649370_1 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001211 279.0
HFD2_k127_6649370_2 transferase activity, transferring glycosyl groups - - - 0.00000000004218 69.0
HFD2_k127_6661505_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 2.763e-205 660.0
HFD2_k127_6661505_1 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 574.0
HFD2_k127_6661505_10 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0000000000000000000000000000000000000000000006196 169.0
HFD2_k127_6661505_11 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000002192 148.0
HFD2_k127_6661505_12 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000000000295 111.0
HFD2_k127_6661505_13 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.0000000000000000009148 87.0
HFD2_k127_6661505_14 structural constituent of ribosome K02911 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000009532 86.0
HFD2_k127_6661505_15 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000001733 78.0
HFD2_k127_6661505_2 electron transfer flavoprotein, alpha subunit K03522,K22432 - 1.3.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 457.0
HFD2_k127_6661505_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 417.0
HFD2_k127_6661505_4 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 403.0
HFD2_k127_6661505_5 electron transfer activity K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 327.0
HFD2_k127_6661505_6 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 314.0
HFD2_k127_6661505_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000002753 252.0
HFD2_k127_6661505_8 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000001712 241.0
HFD2_k127_6661505_9 Endoribonuclease L-PSP K09022 GO:0003674,GO:0003824,GO:0016787,GO:0019239 3.5.99.10 0.0000000000000000000000000000000000000000000001022 171.0
HFD2_k127_6671803_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 5.019e-223 698.0
HFD2_k127_6671803_1 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 521.0
HFD2_k127_6671803_2 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 358.0
HFD2_k127_6671803_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.00000000000000000000000000000000000000000001008 166.0
HFD2_k127_670973_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 578.0
HFD2_k127_670973_1 HAF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 338.0
HFD2_k127_670973_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001131 271.0
HFD2_k127_670973_3 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000001053 228.0
HFD2_k127_670973_4 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000000000000001584 213.0
HFD2_k127_670973_5 NapC/NirT cytochrome c family, N-terminal region - - - 0.0000000000000000000000000000000000159 148.0
HFD2_k127_670973_6 amine dehydrogenase activity - - - 0.000000000000000000000000000000003972 145.0
HFD2_k127_670973_7 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000925 87.0
HFD2_k127_670973_8 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000000000001068 76.0
HFD2_k127_670973_9 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.00000000578 68.0
HFD2_k127_6711646_0 His Kinase A (phosphoacceptor) domain K02484,K07636,K07768 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 408.0
HFD2_k127_6711646_1 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 389.0
HFD2_k127_6711646_2 PFAM response regulator receiver K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000279 265.0
HFD2_k127_6711646_3 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000001835 220.0
HFD2_k127_6711646_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000006679 204.0
HFD2_k127_6735766_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 1.583e-210 661.0
HFD2_k127_6735766_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000515 528.0
HFD2_k127_6735766_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009443 349.0
HFD2_k127_6743702_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 471.0
HFD2_k127_6743702_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 477.0
HFD2_k127_6743702_11 PFAM response regulator receiver K02483 - - 0.00000000003763 69.0
HFD2_k127_6743702_12 Tetratricopeptide repeat - - - 0.00000003533 64.0
HFD2_k127_6743702_13 Belongs to the HesB IscA family K13628,K15724 - - 0.0000001618 57.0
HFD2_k127_6743702_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 359.0
HFD2_k127_6743702_3 PFAM cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 287.0
HFD2_k127_6743702_4 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000003456 226.0
HFD2_k127_6743702_5 Maf-like protein K00014,K03215,K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 1.1.1.25,2.1.1.190 0.000000000000000000000000000000000000000000000000557 181.0
HFD2_k127_6743702_6 SMART Nucleotide binding protein, PINc K07175 - - 0.000000000000000000000000000000000000000001663 156.0
HFD2_k127_6743702_7 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000002001 138.0
HFD2_k127_6743702_9 Protein of unknown function (DUF3467) - - - 0.0000000000000000003696 91.0
HFD2_k127_6800456_0 COGs COG4383 Mu-like prophage protein gp29 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007242 364.0
HFD2_k127_6800456_1 COGs COG4397 Mu-like prophage major head subunit gpT - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009811 287.0
HFD2_k127_6800456_2 COGs COG4388 Mu-like prophage I protein - - - 0.00000000000000000000000000000000000000000000000000000004803 205.0
HFD2_k127_6800456_3 - - - - 0.000000000000000000000000000002777 124.0
HFD2_k127_6853129_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 362.0
HFD2_k127_6853129_1 PFAM Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000008951 250.0
HFD2_k127_6853129_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.000000000000000000000000000000000000000000000000000000000002101 211.0
HFD2_k127_6923468_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 489.0
HFD2_k127_6923468_1 PFAM Pyruvate carboxyltransferase K02594 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 411.0
HFD2_k127_6923468_10 4Fe-4S dicluster domain - - - 0.00000000000000000000000002571 110.0
HFD2_k127_6923468_11 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000001475 84.0
HFD2_k127_6923468_12 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00007494 46.0
HFD2_k127_6923468_2 Elongator protein 3, MiaB family, Radical SAM K02585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 333.0
HFD2_k127_6923468_3 PFAM Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007284 280.0
HFD2_k127_6923468_4 ABC transporter K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000002648 251.0
HFD2_k127_6923468_5 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000002428 214.0
HFD2_k127_6923468_6 Nitrogen regulatory protein P-II K02589 - - 0.00000000000000000000000000000000000000000005461 162.0
HFD2_k127_6923468_7 Dinitrogenase iron-molybdenum cofactor K02596 - - 0.000000000000000000000000000000000000000006655 158.0
HFD2_k127_6923468_8 PFAM NifQ family protein K15790 - - 0.0000000000000000000000000000000007155 134.0
HFD2_k127_6923468_9 Nitrogen regulatory protein P-II K02590 - - 0.000000000000000000000000000001623 129.0
HFD2_k127_6928714_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.069e-234 748.0
HFD2_k127_6928714_1 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000001236 144.0
HFD2_k127_6991_0 Peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008289 550.0
HFD2_k127_6991_1 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 353.0
HFD2_k127_6991_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000001225 193.0
HFD2_k127_6991_3 Phospholipid methyltransferase - - - 0.0000000000000000000000000000002057 134.0
HFD2_k127_7003833_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 5.102e-202 643.0
HFD2_k127_7003833_1 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 1.234e-199 632.0
HFD2_k127_7003833_10 - - - - 0.00001336 48.0
HFD2_k127_7003833_2 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 403.0
HFD2_k127_7003833_3 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 349.0
HFD2_k127_7003833_4 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 295.0
HFD2_k127_7003833_5 Fic/DOC family K04095 - - 0.0000000000000000000000000000000000000000000000000000000000000000003438 235.0
HFD2_k127_7003833_6 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000001405 205.0
HFD2_k127_7003833_7 Domain of unknown function (DUF4412) - - - 0.0000000000000000000000000000007056 130.0
HFD2_k127_7003833_8 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000000002437 90.0
HFD2_k127_7003833_9 COG1361 S-layer domain - - - 0.000007264 52.0
HFD2_k127_7008951_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 345.0
HFD2_k127_7008951_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 310.0
HFD2_k127_7008951_2 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 292.0
HFD2_k127_7008951_3 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003085 252.0
HFD2_k127_7008951_4 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000001685 229.0
HFD2_k127_7008951_5 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000000000000000000000000000000000000000000002593 210.0
HFD2_k127_7008951_6 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.00000000000000000000000000000000000000000000001895 179.0
HFD2_k127_7021421_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 429.0
HFD2_k127_7021421_1 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 375.0
HFD2_k127_7021421_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 354.0
HFD2_k127_7021421_3 Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000008392 201.0
HFD2_k127_7021421_4 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000006303 158.0
HFD2_k127_7021421_5 amine dehydrogenase activity - - - 0.00000000000000000000000000000004367 141.0
HFD2_k127_7095640_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 457.0
HFD2_k127_7095640_1 Dehydrogenase E1 component K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 386.0
HFD2_k127_7095640_10 Transketolase, central region K00615 - 2.2.1.1 0.000000000000000000000000000000000006831 138.0
HFD2_k127_7095640_11 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811,K09812 GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 - 0.00000000000000000000000000000906 129.0
HFD2_k127_7095640_12 - - - - 0.00000000000000000000000000001312 121.0
HFD2_k127_7095640_13 - - - - 0.0000000000001284 72.0
HFD2_k127_7095640_14 BON domain K04065 - - 0.00000000001137 65.0
HFD2_k127_7095640_16 Endonuclease/Exonuclease/phosphatase family - - - 0.0000023 59.0
HFD2_k127_7095640_2 Transketolase K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 285.0
HFD2_k127_7095640_3 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002918 268.0
HFD2_k127_7095640_4 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001449 247.0
HFD2_k127_7095640_5 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000001032 239.0
HFD2_k127_7095640_6 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000199 246.0
HFD2_k127_7095640_8 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000009048 162.0
HFD2_k127_7095640_9 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000000000000000000000002274 156.0
HFD2_k127_715980_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0 1205.0
HFD2_k127_715980_1 phosphorelay signal transduction system K02584,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004028 250.0
HFD2_k127_715980_2 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000001056 241.0
HFD2_k127_715980_3 Bacteriophage CI repressor helix-turn-helix domain - - - 0.00000006116 60.0
HFD2_k127_715980_4 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000006267 57.0
HFD2_k127_715980_5 PFAM UspA domain protein - - - 0.000009414 53.0
HFD2_k127_7221694_0 CO dehydrogenase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 306.0
HFD2_k127_7221694_1 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000007671 154.0
HFD2_k127_7221694_2 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000001261 151.0
HFD2_k127_7225217_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 6.371e-248 780.0
HFD2_k127_7225217_1 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000162 215.0
HFD2_k127_7225217_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000005224 201.0
HFD2_k127_7240085_0 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 3.782e-196 634.0
HFD2_k127_7240085_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 472.0
HFD2_k127_7240085_2 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 343.0
HFD2_k127_7240085_3 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 322.0
HFD2_k127_7240085_4 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004662 282.0
HFD2_k127_7240085_5 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006302 274.0
HFD2_k127_7240085_6 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000005293 190.0
HFD2_k127_7240085_7 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000000000000000000000000000000649 194.0
HFD2_k127_7240085_8 cAMP biosynthetic process - - - 0.00000000000000000006331 105.0
HFD2_k127_7252784_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 565.0
HFD2_k127_7252784_1 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 449.0
HFD2_k127_7252784_2 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 356.0
HFD2_k127_7252784_3 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000146 280.0
HFD2_k127_7252784_4 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000000005072 232.0
HFD2_k127_7252784_5 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000009506 242.0
HFD2_k127_7252784_6 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000001359 219.0
HFD2_k127_7252784_7 12 heme-binding sites - - - 0.00000000000000000001138 97.0
HFD2_k127_7252784_8 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000003071 91.0
HFD2_k127_7252784_9 - - - - 0.0000001186 53.0
HFD2_k127_7284284_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 514.0
HFD2_k127_7284284_1 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 512.0
HFD2_k127_7284284_2 Modulates RecA activity K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000002378 89.0
HFD2_k127_7300214_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 342.0
HFD2_k127_7300214_1 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 326.0
HFD2_k127_7300214_2 Isocitrate isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 303.0
HFD2_k127_7300214_3 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K14696 - - 0.000000000000000000000000000000000000000000001733 177.0
HFD2_k127_732637_0 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 456.0
HFD2_k127_732637_1 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002596 265.0
HFD2_k127_732637_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000009805 98.0
HFD2_k127_7362035_0 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006107 510.0
HFD2_k127_7362035_1 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004964 271.0
HFD2_k127_7362035_2 RecF/RecN/SMC N terminal domain K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004147 252.0
HFD2_k127_7362035_3 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000006774 141.0
HFD2_k127_7362035_4 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000007981 124.0
HFD2_k127_7362035_5 cell redox homeostasis - - - 0.0000000000000000000005639 98.0
HFD2_k127_7362035_6 PFAM Thioredoxin K03671 - - 0.000000000000000000006961 97.0
HFD2_k127_7387502_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 616.0
HFD2_k127_7387502_1 RNA helicase K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 344.0
HFD2_k127_7387502_2 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 303.0
HFD2_k127_7403918_0 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 323.0
HFD2_k127_7403918_1 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 321.0
HFD2_k127_7403918_2 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000000000000000000000000000000001126 215.0
HFD2_k127_7403918_3 sodium-dependent phosphate transmembrane transporter activity K14683 - - 0.0000000000000000000000007204 111.0
HFD2_k127_7419927_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 519.0
HFD2_k127_7419927_1 PFAM Thiamine pyrophosphate K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 441.0
HFD2_k127_7419927_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 411.0
HFD2_k127_7419927_3 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001181 278.0
HFD2_k127_7419927_4 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000001589 237.0
HFD2_k127_7419927_5 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000008372 232.0
HFD2_k127_7419927_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000461 138.0
HFD2_k127_7419927_7 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.0000000000000000000000000000000000808 138.0
HFD2_k127_7419927_8 Fibronectin type III domain protein - - - 0.000000000000000000000005843 118.0
HFD2_k127_742141_0 spermidine synthase activity - - - 7.75e-254 807.0
HFD2_k127_742141_1 Signal transduction histidine kinase, nitrogen specific, NtrB K07708,K10942 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001476 269.0
HFD2_k127_7428984_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 351.0
HFD2_k127_7428984_1 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 336.0
HFD2_k127_7428984_2 Tetratricopeptide repeat - - - 0.00008955 49.0
HFD2_k127_7455491_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1172.0
HFD2_k127_7455491_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 368.0
HFD2_k127_7455491_10 tRNA_anti-like - - - 0.0003381 48.0
HFD2_k127_7455491_2 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 302.0
HFD2_k127_7455491_3 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000003477 269.0
HFD2_k127_7455491_4 TIGRFAM phosphodiesterase, MJ0936 - - - 0.000000000000000000000000000000000000000000000000000000009736 209.0
HFD2_k127_7455491_5 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000000000000000000000000000000369 141.0
HFD2_k127_7455491_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000004461 141.0
HFD2_k127_7455491_7 4Fe-4S binding domain - - - 0.000000000000000000000000000000002646 137.0
HFD2_k127_7455491_8 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000002184 127.0
HFD2_k127_7455491_9 - - - - 0.0000000000000000002793 90.0
HFD2_k127_7470289_0 Glycosyltransferase like family 2 K07011,K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 589.0
HFD2_k127_7470289_1 Sulfatase - - - 0.000000000000000000000000000000000000002112 159.0
HFD2_k127_7470289_2 Glycosyltransferase WbsX - - - 0.000000000000000003362 89.0
HFD2_k127_7503690_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 512.0
HFD2_k127_7503690_1 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 399.0
HFD2_k127_7503690_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003357 224.0
HFD2_k127_7503690_3 - - - - 0.00000000000000000000000000000000000000000000000000000000001759 216.0
HFD2_k127_7503690_4 - - - - 0.0000000000000000000000000000000000000000000000000008005 197.0
HFD2_k127_7503690_5 PQQ enzyme repeat - - - 0.00000000000000000000000000000008786 141.0
HFD2_k127_7503690_6 alginic acid biosynthetic process - - - 0.0000000000000000000000000000005161 138.0
HFD2_k127_7503690_7 HEPN domain - - - 0.000000000000000000000000008541 113.0
HFD2_k127_7503690_8 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000000000001101 111.0
HFD2_k127_7503690_9 Putative nucleotidyltransferase DUF294 - - - 0.0003668 48.0
HFD2_k127_7528224_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 454.0
HFD2_k127_7528224_1 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001258 276.0
HFD2_k127_7528224_2 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000004536 218.0
HFD2_k127_7528224_3 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000001608 180.0
HFD2_k127_7528224_4 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000002952 171.0
HFD2_k127_7528224_5 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.0000000000000000000000008075 106.0
HFD2_k127_7528224_6 O-Antigen Polymerase K18814 - - 0.00000000007384 72.0
HFD2_k127_7528224_7 Domain of unknown function (DUF1972) - - - 0.000000004507 68.0
HFD2_k127_7528224_8 Right handed beta helix region - - - 0.00005792 56.0
HFD2_k127_7573756_0 symporter activity K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 505.0
HFD2_k127_7573756_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 295.0
HFD2_k127_7573756_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000009792 223.0
HFD2_k127_7573756_3 GAF domain - - - 0.00000000000000000000000000000000000000000000000000003751 201.0
HFD2_k127_7573756_4 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000005042 94.0
HFD2_k127_7574001_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 535.0
HFD2_k127_7574001_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000002256 226.0
HFD2_k127_7680436_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 432.0
HFD2_k127_7680436_1 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000009076 228.0
HFD2_k127_7680436_2 Late embryogenesis abundant protein - - - 0.0000002551 59.0
HFD2_k127_7681732_0 Belongs to the CarB family K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 507.0
HFD2_k127_7681732_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 389.0
HFD2_k127_7681732_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000000000000000002202 220.0
HFD2_k127_7681732_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000001926 196.0
HFD2_k127_7681732_4 5'-nucleotidase - - - 0.0000000001426 70.0
HFD2_k127_7697108_0 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 381.0
HFD2_k127_7697108_1 SMART PAS domain containing protein - - - 0.00000000000000007959 93.0
HFD2_k127_7697108_2 sequence-specific DNA binding - - - 0.000000000421 66.0
HFD2_k127_7706708_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 370.0
HFD2_k127_7734897_0 Histidine kinase K20974 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005486 286.0
HFD2_k127_7734897_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000005598 235.0
HFD2_k127_7734897_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000001685 179.0
HFD2_k127_7734897_3 Glycosyl transferase family 2 K07011 - - 0.0000000001461 64.0
HFD2_k127_7757355_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 372.0
HFD2_k127_7757355_1 PFAM Uncharacterised protein family UPF0150 K18843 - - 0.00000000000000000000000000000005455 130.0
HFD2_k127_7757355_2 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000005637 81.0
HFD2_k127_7769247_0 Asparaginase K01424,K13051 - 3.4.19.5,3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000001138 235.0
HFD2_k127_7769247_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000005838 146.0
HFD2_k127_7769247_2 Domain of Unknown Function (DUF748) - - - 0.0000000000000000006028 89.0
HFD2_k127_7769247_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000001582 64.0
HFD2_k127_7797268_0 amine oxidase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 387.0
HFD2_k127_7797268_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738,K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000001099 209.0
HFD2_k127_7797268_2 ATP-binding region, ATPase domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000608 200.0
HFD2_k127_7797268_3 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000000004833 168.0
HFD2_k127_7797268_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000000000000000000000003552 143.0
HFD2_k127_7797268_5 rubredoxin - - - 0.0000000000000000000000001738 106.0
HFD2_k127_7818252_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 395.0
HFD2_k127_7818252_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 322.0
HFD2_k127_7818252_10 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000001353 113.0
HFD2_k127_7818252_11 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000004425 112.0
HFD2_k127_7818252_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000001002 84.0
HFD2_k127_7818252_13 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000467 74.0
HFD2_k127_7818252_2 Ribosomal protein L3 K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000915 256.0
HFD2_k127_7818252_3 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000008536 226.0
HFD2_k127_7818252_4 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000244 229.0
HFD2_k127_7818252_5 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000005678 197.0
HFD2_k127_7818252_6 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000005858 181.0
HFD2_k127_7818252_7 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000001645 141.0
HFD2_k127_7818252_8 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000002203 136.0
HFD2_k127_7818252_9 its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000172 135.0
HFD2_k127_7822414_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000792 594.0
HFD2_k127_7822414_1 PFAM regulatory protein, MarR - - - 0.00000000000000000000000000002579 120.0
HFD2_k127_7822414_2 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000009614 98.0
HFD2_k127_7822414_3 - - - - 0.000001591 59.0
HFD2_k127_7833506_0 nitric oxide dioxygenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008573 317.0
HFD2_k127_7833506_1 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000003454 206.0
HFD2_k127_7833506_10 Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c - GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.00000000000008027 83.0
HFD2_k127_7833506_11 peptidyl-tyrosine sulfation - - - 0.000000000006239 77.0
HFD2_k127_7833506_12 cellulase activity K01181 - 3.2.1.8 0.00000000004544 76.0
HFD2_k127_7833506_13 zinc ion binding - - - 0.000000003949 69.0
HFD2_k127_7833506_14 NHL repeat - GO:0000932,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0017151,GO:0019899,GO:0032991,GO:0035770,GO:0036464,GO:0040034,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0045962,GO:0050789,GO:0050793,GO:0060293,GO:0065007,GO:1990904 - 0.0000007547 59.0
HFD2_k127_7833506_2 denitrification pathway K00380 - 1.8.1.2 0.00000000000000000000000000000000000000000002207 184.0
HFD2_k127_7833506_3 NHL repeat - - - 0.000000000000000000000000000000004838 146.0
HFD2_k127_7833506_4 denitrification pathway K00380 - 1.8.1.2 0.0000000000000000000000000000002615 143.0
HFD2_k127_7833506_5 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.0000000000000000000000000009045 131.0
HFD2_k127_7833506_6 Peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.000000000000000000004473 108.0
HFD2_k127_7833506_7 COG0607 Rhodanese-related sulfurtransferase K03406,K21028 - 2.8.1.11 0.0000000000000000000682 94.0
HFD2_k127_7833506_8 Putative bacterial lipoprotein (DUF799) K21008 - - 0.0000000000000002353 89.0
HFD2_k127_7833506_9 cellulase activity - - - 0.000000000000004563 89.0
HFD2_k127_7836711_0 SPFH domain / Band 7 family - - - 4.613e-272 854.0
HFD2_k127_7836711_1 PAS domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 296.0
HFD2_k127_7837124_0 - - - - 0.00000000000000000000000000000001448 136.0
HFD2_k127_7837124_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000364 111.0
HFD2_k127_7837124_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.0001125 48.0
HFD2_k127_7862551_0 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 360.0
HFD2_k127_7862551_1 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000001695 218.0
HFD2_k127_7862551_3 Bacterial lipid A biosynthesis acyltransferase - - - 0.00001748 56.0
HFD2_k127_7875648_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.203e-244 769.0
HFD2_k127_7875648_1 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 505.0
HFD2_k127_7875648_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 460.0
HFD2_k127_7875648_3 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000522 196.0
HFD2_k127_7884512_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 2.162e-223 706.0
HFD2_k127_7884512_1 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 559.0
HFD2_k127_7884512_2 Fe-S oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 390.0
HFD2_k127_7884512_3 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006151 295.0
HFD2_k127_7884512_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000002536 271.0
HFD2_k127_7884512_5 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000001714 202.0
HFD2_k127_7884512_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000001735 108.0
HFD2_k127_7889627_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.204e-293 922.0
HFD2_k127_7889627_1 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005867 245.0
HFD2_k127_7889627_2 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.000002905 53.0
HFD2_k127_794968_0 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 402.0
HFD2_k127_794968_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K22024 - 1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 347.0
HFD2_k127_794968_10 RNA-binding S4 domain protein - - - 0.00000000000000000000569 94.0
HFD2_k127_794968_11 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0004613 51.0
HFD2_k127_794968_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000004185 258.0
HFD2_k127_794968_3 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000003059 241.0
HFD2_k127_794968_4 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000000000000000005045 187.0
HFD2_k127_794968_5 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000002446 194.0
HFD2_k127_794968_6 PFAM Cupin - - - 0.00000000000000000000000000000000000000000002973 163.0
HFD2_k127_794968_7 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000000000000000000000000000002601 156.0
HFD2_k127_794968_8 serine-type endopeptidase activity K04771,K08372 - 3.4.21.107 0.000000000000000000000000000000000000005895 151.0
HFD2_k127_794968_9 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000009998 109.0
HFD2_k127_7964703_0 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 470.0
HFD2_k127_7964703_1 Family 5 K02035,K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 378.0
HFD2_k127_7964703_2 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 289.0
HFD2_k127_7964703_3 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000004106 186.0
HFD2_k127_7964703_4 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000144 144.0
HFD2_k127_7977252_0 Elongator protein 3, MiaB family, Radical SAM - - - 3.648e-199 630.0
HFD2_k127_7977252_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000003144 209.0
HFD2_k127_7977252_2 Protein of unknown function (DUF2892) - - - 0.00000000000000001398 86.0
HFD2_k127_7991447_0 sensor histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 315.0
HFD2_k127_7991447_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001001 230.0
HFD2_k127_7991447_2 ATP-binding region, ATPase domain protein domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001835 239.0
HFD2_k127_7993088_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 454.0
HFD2_k127_7993088_1 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000448 264.0
HFD2_k127_7993088_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005825 259.0
HFD2_k127_7993088_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001645 244.0
HFD2_k127_7993088_4 phosphorelay sensor kinase activity K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000009504 225.0
HFD2_k127_7993088_5 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000001268 220.0
HFD2_k127_7993088_6 AraC-like ligand binding domain - - - 0.0000000000000000000000000000000000000008786 151.0
HFD2_k127_7993434_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1049.0
HFD2_k127_7993434_1 Signal transduction histidine kinase - - - 0.000000000000000000000000000000005125 140.0
HFD2_k127_7993434_2 Tetratricopeptide repeat - - - 0.0000000000000000001515 94.0
HFD2_k127_7993434_3 TPR repeat-containing protein - - - 0.0000000000000001218 87.0
HFD2_k127_7996006_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 542.0
HFD2_k127_7996006_1 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 520.0
HFD2_k127_7996006_10 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000003992 192.0
HFD2_k127_7996006_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000003059 180.0
HFD2_k127_7996006_12 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000000000002923 156.0
HFD2_k127_7996006_13 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000006936 149.0
HFD2_k127_7996006_14 nucleotidyltransferase activity - - - 0.0000000000000000000000000001125 124.0
HFD2_k127_7996006_15 TPR repeat-containing protein - - - 0.00000000000000000007817 100.0
HFD2_k127_7996006_17 - - - - 0.0000000000000001225 83.0
HFD2_k127_7996006_18 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.000000000000004092 81.0
HFD2_k127_7996006_19 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000002976 66.0
HFD2_k127_7996006_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 327.0
HFD2_k127_7996006_20 nitrogen fixation - - - 0.00000000008566 67.0
HFD2_k127_7996006_21 peroxiredoxin activity K01607 - 4.1.1.44 0.00000001252 59.0
HFD2_k127_7996006_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 - 3.1.11.2,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007791 286.0
HFD2_k127_7996006_4 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000001067 240.0
HFD2_k127_7996006_5 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000214 223.0
HFD2_k127_7996006_6 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000173 206.0
HFD2_k127_7996006_7 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000002087 203.0
HFD2_k127_7996006_8 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000000000000000314 200.0
HFD2_k127_7996006_9 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000193 198.0
HFD2_k127_8005765_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1134.0
HFD2_k127_8005765_1 endonuclease III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005476 264.0
HFD2_k127_8005765_2 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000002944 211.0
HFD2_k127_8005765_3 Cold shock K03704 - - 0.0000000000000000000000001212 107.0
HFD2_k127_8005765_4 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000002975 80.0
HFD2_k127_8018568_0 RNA polymerases D K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 400.0
HFD2_k127_8018568_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 308.0
HFD2_k127_8018568_10 Nucleotidyltransferase domain K07075 - - 0.0000001267 58.0
HFD2_k127_8018568_2 HDIG domain protein K06950 - - 0.0000000000000000000000000000000000000000000000000000000002837 207.0
HFD2_k127_8018568_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001784 199.0
HFD2_k127_8018568_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000004161 192.0
HFD2_k127_8018568_5 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000004081 160.0
HFD2_k127_8018568_6 Phosphoesterase K07095 - - 0.0000000000000000000000000000000000000003029 154.0
HFD2_k127_8018568_7 Protein of unknown function DUF86 - - - 0.000000000000000000000000000002963 123.0
HFD2_k127_8018568_8 TIGRFAM histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000022 94.0
HFD2_k127_8018568_9 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000001125 70.0
HFD2_k127_8050553_0 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000001218 116.0
HFD2_k127_8050553_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000001637 94.0
HFD2_k127_8050553_2 Psort location CytoplasmicMembrane, score - - - 0.000000000000655 80.0
HFD2_k127_8050553_3 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000001576 66.0
HFD2_k127_8050553_4 mRNA binding K07339 - - 0.00000000009717 64.0
HFD2_k127_80847_0 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 462.0
HFD2_k127_80847_1 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 398.0
HFD2_k127_8143304_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 434.0
HFD2_k127_8143304_1 PFAM Transketolase central region K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 377.0
HFD2_k127_8143304_10 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000108 86.0
HFD2_k127_8143304_11 periplasmic or secreted lipoprotein - - - 0.00000000003381 66.0
HFD2_k127_8143304_2 Tryptophanyl-tRNA synthetase K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 378.0
HFD2_k127_8143304_3 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 349.0
HFD2_k127_8143304_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 310.0
HFD2_k127_8143304_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000001941 223.0
HFD2_k127_8143304_6 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000000163 230.0
HFD2_k127_8143304_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000009171 209.0
HFD2_k127_8143304_8 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000001561 121.0
HFD2_k127_8143304_9 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000001839 115.0
HFD2_k127_8148692_0 Predicted permease - - - 0.00000000000000000000000000000000000000000000000000005654 199.0
HFD2_k127_8148692_1 Tetrapyrrole (Corrin/Porphyrin) Methylases - - - 0.00000000000000000000000000000000000000000000000001244 190.0
HFD2_k127_8148692_2 peptidase U32 - - - 0.0000000000000000000000000000037 130.0
HFD2_k127_8148692_3 Peptidase family U32 - - - 0.00000000000000000001704 96.0
HFD2_k127_8148692_4 COG NOG19146 non supervised orthologous group - - - 0.000000000000003954 85.0
HFD2_k127_8148692_5 Right handed beta helix region - - - 0.0000000001204 69.0
HFD2_k127_8153124_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 318.0
HFD2_k127_8153124_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 308.0
HFD2_k127_8153124_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 306.0
HFD2_k127_8153124_4 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000001963 110.0
HFD2_k127_8153124_5 hydrolase, family 25 - - - 0.00002307 55.0
HFD2_k127_8153949_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.055e-238 748.0
HFD2_k127_8153949_1 PFAM Rh family protein ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 594.0
HFD2_k127_8153949_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 516.0
HFD2_k127_8153949_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 388.0
HFD2_k127_8153949_4 Alternative locus ID - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001345 275.0
HFD2_k127_8153949_5 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000003384 194.0
HFD2_k127_8153949_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000001173 155.0
HFD2_k127_8153949_7 PFAM histidine kinase, HAMP region domain protein K03406 - - 0.00000000002973 67.0
HFD2_k127_8153949_8 thiolester hydrolase activity K06889 - - 0.0000000005568 69.0
HFD2_k127_8209202_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 510.0
HFD2_k127_8209202_1 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 361.0
HFD2_k127_8209202_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 357.0
HFD2_k127_8209202_3 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.00000000000000000000000000000000003231 137.0
HFD2_k127_8265859_0 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 395.0
HFD2_k127_8265859_1 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 394.0
HFD2_k127_8265859_2 HD domain - - - 0.000000000000000000000000000000000000000000000000000347 200.0
HFD2_k127_8265859_3 Belongs to the GbsR family - - - 0.0000000000000000000000000000000000003627 146.0
HFD2_k127_8265859_4 antisigma factor binding - - - 0.0000000000003387 76.0
HFD2_k127_8265859_5 - - - - 0.00003882 56.0
HFD2_k127_8265859_6 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.0004736 53.0
HFD2_k127_8273196_0 Type II and III secretion system protein K02666 - - 0.00000000000000000000000000000000000000000000000000000001714 222.0
HFD2_k127_8273196_1 Pilus assembly protein, PilP K02665 - - 0.00000000001291 74.0
HFD2_k127_8273196_2 COG3166 Tfp pilus assembly protein PilN K02663 - - 0.000000648 58.0
HFD2_k127_8273196_3 Pilus assembly protein PilO K02664 - - 0.0000008644 58.0
HFD2_k127_8316836_0 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 416.0
HFD2_k127_8316836_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.0000000000000000000000000001775 118.0
HFD2_k127_8327643_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 8.083e-235 736.0
HFD2_k127_8327643_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 558.0
HFD2_k127_8327643_2 PFAM secretion protein HlyD family protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 385.0
HFD2_k127_8327643_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008343 351.0
HFD2_k127_8327643_4 PFAM 2-hydroxyglutaryl-CoA dehydratase D-component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008797 330.0
HFD2_k127_8327643_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000004012 256.0
HFD2_k127_8327643_6 - - - - 0.0000000000000000000000000000002291 128.0
HFD2_k127_8340642_0 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 452.0
HFD2_k127_8340642_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000001162 230.0
HFD2_k127_8340642_2 heat shock protein binding - - - 0.000000000000008867 78.0
HFD2_k127_8377178_0 helicase superfamily c-terminal domain K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 521.0
HFD2_k127_8377178_1 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 487.0
HFD2_k127_8377178_2 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 375.0
HFD2_k127_8377178_3 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 352.0
HFD2_k127_8377178_4 electron transport complex, RnfABCDGE type, B subunit K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002104 284.0
HFD2_k127_8377178_5 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001688 243.0
HFD2_k127_8377178_6 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000005677 231.0
HFD2_k127_8377178_7 Part of a membrane complex involved in electron transport K03612 - - 0.0000000000000000000000000000000000933 141.0
HFD2_k127_8381507_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 1.924e-204 646.0
HFD2_k127_8381507_1 Tellurite resistance protein TehB - - - 0.00000000000000000000000000001532 119.0
HFD2_k127_840328_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 359.0
HFD2_k127_840328_1 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000002056 203.0
HFD2_k127_840328_2 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.0000000000000000000000000000000000000000002288 166.0
HFD2_k127_840328_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000265 164.0
HFD2_k127_840328_4 MotA/TolQ/ExbB proton channel family K03561,K03562 - - 0.000000000000000000000000000000000000003836 153.0
HFD2_k127_840328_5 - - - - 0.000000000000000000000000000000000001691 144.0
HFD2_k127_840328_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000001381 99.0
HFD2_k127_840328_7 Biopolymer transport protein ExbD TolR K03559 - - 0.000000000000000002865 89.0
HFD2_k127_840328_8 - - - - 0.0000001812 61.0
HFD2_k127_84178_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 320.0
HFD2_k127_84178_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000007291 226.0
HFD2_k127_84178_2 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000009131 214.0
HFD2_k127_84178_3 zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000000000000000002758 207.0
HFD2_k127_84178_4 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000002233 154.0
HFD2_k127_84178_5 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.00000000000000000214 87.0
HFD2_k127_84178_8 Belongs to the peptidase M16 family - - - 0.0001855 52.0
HFD2_k127_8423594_0 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 482.0
HFD2_k127_8423594_1 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000006566 183.0
HFD2_k127_8423594_2 Universal stress protein K06149 - - 0.0000000000000000000000001516 111.0
HFD2_k127_8423594_3 response regulator receiver K13599 - - 0.0000000000000000007959 95.0
HFD2_k127_8471283_0 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 1.052e-195 617.0
HFD2_k127_8471283_1 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 563.0
HFD2_k127_8471283_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 531.0
HFD2_k127_8471283_3 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 509.0
HFD2_k127_8471283_4 Metalloenzyme superfamily K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 486.0
HFD2_k127_8471283_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 350.0
HFD2_k127_8471283_6 Ankyrin repeat protein - - - 0.000000000000000000000000000000000000005001 153.0
HFD2_k127_8471283_7 cation transport ATPase K01537 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 0.0000000000005268 71.0
HFD2_k127_8484112_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1112.0
HFD2_k127_8484112_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 5.176e-205 651.0
HFD2_k127_8484112_10 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000238 94.0
HFD2_k127_8484112_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000004458 84.0
HFD2_k127_8484112_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 366.0
HFD2_k127_8484112_3 ATPases associated with a variety of cellular activities K01990,K11050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 361.0
HFD2_k127_8484112_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 301.0
HFD2_k127_8484112_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000001216 274.0
HFD2_k127_8484112_6 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002348 259.0
HFD2_k127_8484112_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000001245 186.0
HFD2_k127_8484112_8 Transport permease protein K01992 - - 0.00000000000000000000000000000000000001913 150.0
HFD2_k127_8484112_9 Preprotein translocase SecG subunit K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000007701 100.0
HFD2_k127_8484272_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 587.0
HFD2_k127_8484272_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 299.0
HFD2_k127_8484272_10 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000004873 79.0
HFD2_k127_8484272_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003501 270.0
HFD2_k127_8484272_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000004029 224.0
HFD2_k127_8484272_4 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000003043 218.0
HFD2_k127_8484272_5 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000002201 209.0
HFD2_k127_8484272_6 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000002929 188.0
HFD2_k127_8484272_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000002432 184.0
HFD2_k127_8484272_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000126 156.0
HFD2_k127_8484272_9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000008485 104.0
HFD2_k127_8541901_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006792 327.0
HFD2_k127_8541901_1 Histidine kinase - - - 0.000000000000000000000000000000000000001353 163.0
HFD2_k127_8541901_2 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000007551 154.0
HFD2_k127_8541901_3 Histidine kinase A domain protein - - - 0.000000000000000000000000004192 125.0
HFD2_k127_8541901_4 PFAM Lytic transglycosylase catalytic K08309 - - 0.00000000000000000000000002564 115.0
HFD2_k127_8541901_5 PFAM 4Fe-4S ferredoxin K08358 - - 0.000000000000000009756 84.0
HFD2_k127_8569185_0 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004016 270.0
HFD2_k127_8569185_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001558 256.0
HFD2_k127_8569185_2 phosphoglycerate mutase K15634 - 5.4.2.12 0.000000000000000000000001642 111.0
HFD2_k127_8569185_3 4Fe-4S single cluster domain K06937 - - 0.000000000000000000000014 111.0
HFD2_k127_8571050_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 1.329e-227 713.0
HFD2_k127_8571050_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 3.843e-204 651.0
HFD2_k127_8571050_2 NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006106 392.0
HFD2_k127_8571050_3 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000003016 187.0
HFD2_k127_8571050_4 PFAM NADH Ubiquinone plastoquinone (complex I) K12141 - - 0.00000000000000000000002723 100.0
HFD2_k127_8571050_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03407 - 2.7.13.3 0.0002962 43.0
HFD2_k127_8586374_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 7.852e-199 627.0
HFD2_k127_8586374_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006841 608.0
HFD2_k127_8586374_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 520.0
HFD2_k127_8586374_3 PFAM Na Picotransporter K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 401.0
HFD2_k127_8586374_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000244 223.0
HFD2_k127_8586374_5 mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000001718 190.0
HFD2_k127_8586374_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000008992 117.0
HFD2_k127_8586374_7 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000001086 70.0
HFD2_k127_863516_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 5.299e-305 958.0
HFD2_k127_863516_1 AMP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000001458 239.0
HFD2_k127_863516_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000127 136.0
HFD2_k127_881118_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009329 311.0
HFD2_k127_881118_1 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000001384 297.0
HFD2_k127_881118_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000004087 203.0
HFD2_k127_881118_3 isochorismatase K06901 - - 0.0000000000000000000000000000000000000000000000000000006107 199.0
HFD2_k127_881118_4 Response regulator receiver domain - - - 0.0000000000000000000000000000000001716 136.0
HFD2_k127_881118_5 - - - - 0.0000000000000000000000000000000004388 135.0
HFD2_k127_881118_6 exonuclease activity K16899 - 3.6.4.12 0.0000000000000000000002203 114.0
HFD2_k127_913116_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 3.02e-249 788.0
HFD2_k127_913116_1 DNA polymerase K02347 - - 5.912e-213 675.0
HFD2_k127_913116_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000004868 151.0
HFD2_k127_913116_11 coenzyme binding K07071 - - 0.0000000000000000000000000000000000002614 153.0
HFD2_k127_913116_12 metal-dependent phosphohydrolase HD sub domain - - - 0.000000000000000000000000000000002001 146.0
HFD2_k127_913116_13 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000002838 117.0
HFD2_k127_913116_14 PFAM Rubredoxin-type Fe(Cys)4 protein K05297 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592 1.18.1.1 0.00000000000000000000005067 98.0
HFD2_k127_913116_15 glycoside hydrolase family 81 - - - 0.000000000000000003206 100.0
HFD2_k127_913116_17 PFAM Rhodanese domain protein - - - 0.000000003505 64.0
HFD2_k127_913116_18 DNA polymerase alpha chain like domain - - - 0.000000005855 66.0
HFD2_k127_913116_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 549.0
HFD2_k127_913116_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 530.0
HFD2_k127_913116_4 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 539.0
HFD2_k127_913116_5 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 508.0
HFD2_k127_913116_6 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 494.0
HFD2_k127_913116_7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009947 464.0
HFD2_k127_913116_8 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 308.0
HFD2_k127_913116_9 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000006149 195.0
HFD2_k127_915828_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 4.537e-203 648.0
HFD2_k127_915828_1 Conserved protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001421 271.0
HFD2_k127_915828_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000009795 102.0
HFD2_k127_916692_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 467.0
HFD2_k127_916692_1 TIGRFAM cysteine K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 420.0
HFD2_k127_916692_2 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000004132 187.0
HFD2_k127_916692_3 DsrC like protein K11179 - - 0.00000000000000000000000000000002245 127.0
HFD2_k127_916692_4 SMART phosphoesterase PHP domain protein - - - 0.00000000000000002248 91.0
HFD2_k127_916692_5 electron transfer activity - - - 0.00000000000007597 76.0
HFD2_k127_916692_6 energy transducer activity K03832 - - 0.00004593 55.0
HFD2_k127_926915_0 Uncharacterized protein conserved in bacteria (DUF2344) - - - 5.409e-226 727.0
HFD2_k127_926915_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 577.0
HFD2_k127_926915_2 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 366.0
HFD2_k127_926915_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 346.0
HFD2_k127_926915_4 Involved in formation and maintenance of cell shape K03570 - - 0.000000000005794 68.0
HFD2_k127_926915_5 rod shape-determining protein MreD K03571 - - 0.0000000005541 68.0
HFD2_k127_929390_0 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 627.0
HFD2_k127_929390_1 Homocysteine biosynthesis enzyme, sulfur-incorporation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 533.0
HFD2_k127_929390_2 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 316.0
HFD2_k127_929390_3 NIL - - - 0.00000000000000000000000000005714 120.0
HFD2_k127_929390_4 Cold shock protein K03704 - - 0.0000000000000000000000002855 108.0
HFD2_k127_929390_5 radical SAM domain protein - - - 0.00000000000000000000000206 114.0
HFD2_k127_929390_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000001245 63.0
HFD2_k127_929390_7 - - - - 0.000184 51.0
HFD2_k127_933575_0 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 479.0
HFD2_k127_933575_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 305.0
HFD2_k127_933575_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 301.0
HFD2_k127_933575_3 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003249 285.0
HFD2_k127_933575_4 domain protein - - - 0.000000000000000000000000000000000000000000000000000001264 200.0
HFD2_k127_933575_5 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000005266 186.0
HFD2_k127_933575_6 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.0000000000000000000000000000000000000002659 157.0
HFD2_k127_933575_7 HEAT repeat - - - 0.000000000000000006278 91.0
HFD2_k127_965753_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 537.0
HFD2_k127_965753_1 Tetratricopeptide repeat - - - 0.000000000000000000000000003644 117.0
HFD2_k127_994462_0 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 362.0
HFD2_k127_994462_1 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 288.0
HFD2_k127_994462_2 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 291.0
HFD2_k127_994462_3 Predicted membrane protein (DUF2157) - - - 0.000000000000000000000000000000000000000000000005331 193.0
HFD2_k127_994462_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000001081 143.0
HFD2_k127_994462_5 PASTA domain K12132 - 2.7.11.1 0.0000000000000000000000000177 119.0
HFD2_k127_994462_6 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000001123 94.0
HFD2_k127_994462_7 GDYXXLXY protein - - - 0.0000000000000000001363 94.0