Overview

ID MAG01648
Name HFD2_bin.36
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Polarisedimenticolia
Order Polarisedimenticolales
Family DASRJG01
Genus
Species
Assembly information
Completeness (%) 100.0
Contamination (%) 4.04
GC content (%) 71.0
N50 (bp) 38,652
Genome size (bp) 4,420,836

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3532

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1047385_0 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 443.0
HFD2_k127_1047385_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 464.0
HFD2_k127_1047385_2 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000000000000000000000000000000002116 164.0
HFD2_k127_1047385_3 - - - - 0.0000000000000000000000000004777 125.0
HFD2_k127_1047385_4 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944 - 0.000001267 59.0
HFD2_k127_1047385_5 Periplasmic component of the Tol biopolymer transport system - - - 0.0001316 55.0
HFD2_k127_1078009_0 Tetratricopeptide repeat - - - 1.039e-200 639.0
HFD2_k127_1078009_1 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 334.0
HFD2_k127_1078009_2 - - - - 0.000000000000000000000000000000000000000000000000000000000001177 213.0
HFD2_k127_1078009_3 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000001654 153.0
HFD2_k127_1078009_4 GrpB protein - - - 0.000000000000001671 80.0
HFD2_k127_1142100_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005385 533.0
HFD2_k127_1142100_1 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 492.0
HFD2_k127_1142100_10 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000001347 189.0
HFD2_k127_1142100_11 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000001518 170.0
HFD2_k127_1142100_12 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.0000000000000000000000000000000000000001921 170.0
HFD2_k127_1142100_13 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000001312 135.0
HFD2_k127_1142100_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000002475 139.0
HFD2_k127_1142100_15 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000003699 150.0
HFD2_k127_1142100_16 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.000000000000000000000000000000007149 140.0
HFD2_k127_1142100_17 CcmB protein K02194 - - 0.0000000000000000000000000000009334 139.0
HFD2_k127_1142100_18 Prolyl oligopeptidase family - - - 0.00000000000000000000000000002515 131.0
HFD2_k127_1142100_19 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000006358 112.0
HFD2_k127_1142100_2 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 413.0
HFD2_k127_1142100_20 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000004063 114.0
HFD2_k127_1142100_21 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 GO:0003674,GO:0003824,GO:0004150,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044444,GO:0044464 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000001755 104.0
HFD2_k127_1142100_22 heat shock protein binding K05516,K05801 - - 0.000000000000000000009528 109.0
HFD2_k127_1142100_23 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000002974 79.0
HFD2_k127_1142100_24 YacP-like NYN domain K06962 - - 0.0000000001797 67.0
HFD2_k127_1142100_25 subunit of a heme lyase K02200 - - 0.00000004357 61.0
HFD2_k127_1142100_26 - - - - 0.0004171 51.0
HFD2_k127_1142100_3 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 407.0
HFD2_k127_1142100_4 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008641 338.0
HFD2_k127_1142100_5 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000009964 258.0
HFD2_k127_1142100_6 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000911 238.0
HFD2_k127_1142100_7 PFAM Amidohydrolase 3 - - - 0.0000000000000000000000000000000000000000000000000000000001507 231.0
HFD2_k127_1142100_8 ABC transporter K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000006692 200.0
HFD2_k127_1142100_9 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.00000000000000000000000000000000000000000000000000464 200.0
HFD2_k127_1235561_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.807e-223 709.0
HFD2_k127_1235561_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 550.0
HFD2_k127_1235561_2 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 336.0
HFD2_k127_1235561_3 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008151 305.0
HFD2_k127_1235561_4 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 310.0
HFD2_k127_1235561_5 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000001702 131.0
HFD2_k127_1235561_6 Protein of unknown function (DUF1648) - - - 0.0000000000000000000000001833 121.0
HFD2_k127_1235561_7 Transcriptional regulator, GntR family - - - 0.0000000000000000005288 91.0
HFD2_k127_12357_0 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001486 250.0
HFD2_k127_12357_1 - - - - 0.00000000000001656 77.0
HFD2_k127_1242181_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 389.0
HFD2_k127_1242181_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002123 281.0
HFD2_k127_1242181_2 abc transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001244 282.0
HFD2_k127_1242181_3 EVE domain - - - 0.00000000000000000000000000000000000000000000000001833 184.0
HFD2_k127_1242181_4 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000000000000001048 99.0
HFD2_k127_1242181_5 domain, Protein K15125,K21449 - - 0.0000000000000000001192 101.0
HFD2_k127_1242181_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000002355 62.0
HFD2_k127_1432460_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.102e-243 786.0
HFD2_k127_1432460_1 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 337.0
HFD2_k127_1432460_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000006563 70.0
HFD2_k127_143319_0 Alanine dehydrogenase/PNT, N-terminal domain K00290,K14157 - 1.5.1.7,1.5.1.8,1.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 400.0
HFD2_k127_143319_1 Saccharopine dehydrogenase C-terminal domain K00293 - 1.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 346.0
HFD2_k127_143319_2 Helicase K03579 - 3.6.4.13 0.000000000000000000000000000000000000001796 148.0
HFD2_k127_1467287_0 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0 1476.0
HFD2_k127_1467287_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 4.479e-244 786.0
HFD2_k127_1467287_10 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 472.0
HFD2_k127_1467287_100 Protein of unknown function (DUF2752) - - - 0.00002039 56.0
HFD2_k127_1467287_101 - - - - 0.0002024 54.0
HFD2_k127_1467287_102 salt-induced outer membrane protein K07283 - - 0.0003556 52.0
HFD2_k127_1467287_103 Tetratricopeptide repeat - - - 0.0003682 54.0
HFD2_k127_1467287_104 membrane - - - 0.0009721 46.0
HFD2_k127_1467287_11 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 402.0
HFD2_k127_1467287_12 PFAM SAICAR synthetase K01923,K13713 - 6.3.2.6,6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 390.0
HFD2_k127_1467287_13 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 380.0
HFD2_k127_1467287_14 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 385.0
HFD2_k127_1467287_15 Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007598 377.0
HFD2_k127_1467287_16 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 360.0
HFD2_k127_1467287_17 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 339.0
HFD2_k127_1467287_18 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 316.0
HFD2_k127_1467287_19 Transglycosylase SLT domain K08307,K12204 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 324.0
HFD2_k127_1467287_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 569.0
HFD2_k127_1467287_20 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 308.0
HFD2_k127_1467287_21 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
HFD2_k127_1467287_22 ribosomal L5P family C-terminus K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003878 274.0
HFD2_k127_1467287_23 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000413 280.0
HFD2_k127_1467287_24 Predicted ATPase of the ABC class - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006875 293.0
HFD2_k127_1467287_25 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002783 273.0
HFD2_k127_1467287_26 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005038 269.0
HFD2_k127_1467287_27 Anthranilate synthase component I K01657,K01665,K13950 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000004836 273.0
HFD2_k127_1467287_28 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 260.0
HFD2_k127_1467287_29 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000006343 266.0
HFD2_k127_1467287_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 500.0
HFD2_k127_1467287_30 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000001292 273.0
HFD2_k127_1467287_31 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000002044 250.0
HFD2_k127_1467287_32 glycosyl transferase group 1 K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000003763 259.0
HFD2_k127_1467287_33 PFAM short-chain dehydrogenase reductase SDR - GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 - 0.000000000000000000000000000000000000000000000000000000000000000000000007636 259.0
HFD2_k127_1467287_34 AntiSigma factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000173 250.0
HFD2_k127_1467287_35 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000003103 251.0
HFD2_k127_1467287_36 TIGRFAM rfaE bifunctional protein, domain I - - - 0.0000000000000000000000000000000000000000000000000000000000000000001517 253.0
HFD2_k127_1467287_37 Calcineurin-like phosphoesterase K07099 - - 0.000000000000000000000000000000000000000000000000000000000000000002146 233.0
HFD2_k127_1467287_38 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000005831 229.0
HFD2_k127_1467287_39 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000002452 221.0
HFD2_k127_1467287_4 Oligopeptidase F K08602 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005089 507.0
HFD2_k127_1467287_40 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000005425 218.0
HFD2_k127_1467287_41 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000005156 233.0
HFD2_k127_1467287_42 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000001453 233.0
HFD2_k127_1467287_43 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000001743 220.0
HFD2_k127_1467287_44 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000000000000000000005422 208.0
HFD2_k127_1467287_45 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000001758 205.0
HFD2_k127_1467287_46 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000002662 196.0
HFD2_k127_1467287_47 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000003788 203.0
HFD2_k127_1467287_48 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000184 213.0
HFD2_k127_1467287_49 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000002764 189.0
HFD2_k127_1467287_5 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 491.0
HFD2_k127_1467287_50 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000008982 205.0
HFD2_k127_1467287_51 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000003198 185.0
HFD2_k127_1467287_52 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000003655 182.0
HFD2_k127_1467287_53 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000000407 184.0
HFD2_k127_1467287_54 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000001463 182.0
HFD2_k127_1467287_55 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000004093 191.0
HFD2_k127_1467287_56 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000000000000000000004114 178.0
HFD2_k127_1467287_57 Peptidase family M23 K21471 - - 0.00000000000000000000000000000000000000000000004275 180.0
HFD2_k127_1467287_58 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000004317 172.0
HFD2_k127_1467287_59 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000008925 171.0
HFD2_k127_1467287_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 466.0
HFD2_k127_1467287_60 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000001399 171.0
HFD2_k127_1467287_61 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000003921 175.0
HFD2_k127_1467287_62 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000002932 167.0
HFD2_k127_1467287_63 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000005109 147.0
HFD2_k127_1467287_64 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000002161 143.0
HFD2_k127_1467287_65 structural constituent of ribosome K02879 - - 0.000000000000000000000000000000000001352 146.0
HFD2_k127_1467287_66 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.000000000000000000000000000000000003652 137.0
HFD2_k127_1467287_67 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000001725 156.0
HFD2_k127_1467287_68 diacylglycerol kinase, catalytic region - - - 0.000000000000000000000000000000002049 148.0
HFD2_k127_1467287_69 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.00000000000000000000000000000003177 145.0
HFD2_k127_1467287_7 PFAM magnesium chelatase K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 470.0
HFD2_k127_1467287_70 - - - - 0.0000000000000000000000000000003397 129.0
HFD2_k127_1467287_71 Cupin 2, conserved barrel - - - 0.0000000000000000000000000000005166 126.0
HFD2_k127_1467287_72 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000000000000000000001689 115.0
HFD2_k127_1467287_73 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000005007 121.0
HFD2_k127_1467287_74 Cupin domain - - - 0.0000000000000000000000008121 113.0
HFD2_k127_1467287_75 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000000004865 108.0
HFD2_k127_1467287_76 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000001202 114.0
HFD2_k127_1467287_77 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000005547 111.0
HFD2_k127_1467287_78 EthD domain - - - 0.0000000000000000000008686 96.0
HFD2_k127_1467287_79 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000009068 103.0
HFD2_k127_1467287_8 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 461.0
HFD2_k127_1467287_80 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000005222 104.0
HFD2_k127_1467287_81 Alkylmercury lyase - - - 0.0000000000000000004769 94.0
HFD2_k127_1467287_82 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000114 85.0
HFD2_k127_1467287_83 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000001018 92.0
HFD2_k127_1467287_84 Domain of unknown function (DUF4177) - - - 0.00000000000000004201 83.0
HFD2_k127_1467287_85 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000001709 82.0
HFD2_k127_1467287_86 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000266 76.0
HFD2_k127_1467287_87 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000003908 73.0
HFD2_k127_1467287_88 endopeptidase activity - - - 0.0000000001109 75.0
HFD2_k127_1467287_89 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000001759 74.0
HFD2_k127_1467287_9 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 458.0
HFD2_k127_1467287_91 COG0662 Mannose-6-phosphate isomerase - - - 0.00000001629 67.0
HFD2_k127_1467287_92 Alkylmercury lyase - - - 0.00000001887 58.0
HFD2_k127_1467287_93 PFAM chitin-binding domain 3 protein - - - 0.00000001901 68.0
HFD2_k127_1467287_96 snoRNA binding - - - 0.000000215 61.0
HFD2_k127_1467287_97 Tetratricopeptide repeat - - - 0.0000004633 63.0
HFD2_k127_1467287_98 HEAT repeat - - - 0.0000004921 63.0
HFD2_k127_1467287_99 Tetratricopeptide repeat K02200 - - 0.00001401 57.0
HFD2_k127_1467489_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1971.0
HFD2_k127_1467489_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1901.0
HFD2_k127_1467489_10 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000965 86.0
HFD2_k127_1467489_11 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000114 85.0
HFD2_k127_1467489_12 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000314 82.0
HFD2_k127_1467489_13 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00003616 50.0
HFD2_k127_1467489_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 5.279e-312 971.0
HFD2_k127_1467489_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 320.0
HFD2_k127_1467489_4 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002037 250.0
HFD2_k127_1467489_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000002928 220.0
HFD2_k127_1467489_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001401 210.0
HFD2_k127_1467489_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000007081 215.0
HFD2_k127_1467489_8 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000944 167.0
HFD2_k127_1467489_9 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000009445 119.0
HFD2_k127_1483442_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 619.0
HFD2_k127_1483442_1 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007831 372.0
HFD2_k127_1483442_2 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 330.0
HFD2_k127_1483442_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000004721 246.0
HFD2_k127_1649280_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 1.403e-216 685.0
HFD2_k127_1649280_1 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 576.0
HFD2_k127_1649280_10 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003318 244.0
HFD2_k127_1649280_11 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000001096 226.0
HFD2_k127_1649280_12 FR47-like protein - - - 0.000000000000000000000000000000000000003843 155.0
HFD2_k127_1649280_13 Ankyrin repeat and kinase domain containing 1 K16289 - 2.7.11.1 0.000000000000000000000000000000002332 149.0
HFD2_k127_1649280_14 Stigma-specific protein, Stig1 - - - 0.0000000000000000000000000006399 132.0
HFD2_k127_1649280_15 cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.000000000166 71.0
HFD2_k127_1649280_16 Periplasmic copper-binding protein (NosD) - - - 0.000000005847 68.0
HFD2_k127_1649280_2 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 491.0
HFD2_k127_1649280_3 PFAM Cys Met metabolism K01760,K01761 - 4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 440.0
HFD2_k127_1649280_4 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 434.0
HFD2_k127_1649280_5 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 385.0
HFD2_k127_1649280_6 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 383.0
HFD2_k127_1649280_7 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 369.0
HFD2_k127_1649280_8 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006452 308.0
HFD2_k127_1649280_9 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 296.0
HFD2_k127_1744128_0 Capsular exopolysaccharide family K16554,K16692 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 362.0
HFD2_k127_1744128_2 Polysaccharide export protein K01991 - - 0.000000000000000000000000000000005657 148.0
HFD2_k127_1744128_3 PIN domain - - - 0.00000000000000000000000003207 114.0
HFD2_k127_1744128_4 cellulose binding K07279 - - 0.0000000000000001856 92.0
HFD2_k127_1744128_6 - - - - 0.0000000000429 66.0
HFD2_k127_1744128_7 O-Antigen ligase - - - 0.00000005662 67.0
HFD2_k127_1744128_8 TIGRFAM YD repeat protein - - - 0.0002259 53.0
HFD2_k127_1744128_9 Lamin Tail Domain - - - 0.0004174 53.0
HFD2_k127_1767074_0 Belongs to the ClpA ClpB family K03696 - - 6.387e-287 933.0
HFD2_k127_1767074_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 552.0
HFD2_k127_1767074_10 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000006753 212.0
HFD2_k127_1767074_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000003778 211.0
HFD2_k127_1767074_12 PFAM ABC transporter K02003 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000297 209.0
HFD2_k127_1767074_13 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000004366 206.0
HFD2_k127_1767074_14 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000000000000001777 190.0
HFD2_k127_1767074_15 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000003315 194.0
HFD2_k127_1767074_16 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000007784 196.0
HFD2_k127_1767074_17 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000002463 193.0
HFD2_k127_1767074_18 ggdef domain - - - 0.000000000000000000000000000000000000000000000008025 196.0
HFD2_k127_1767074_19 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000001797 178.0
HFD2_k127_1767074_2 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 394.0
HFD2_k127_1767074_20 Beta-lactamase - - - 0.000000000000000000000000000000000000000000002296 187.0
HFD2_k127_1767074_21 ggdef domain - - - 0.000000000000000000000000000000000000000000008821 182.0
HFD2_k127_1767074_22 ATP-grasp domain K22224 - 6.2.1.13 0.000000000000000000000000000000000000000006871 158.0
HFD2_k127_1767074_23 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000000005864 133.0
HFD2_k127_1767074_24 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000004838 145.0
HFD2_k127_1767074_25 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000593 134.0
HFD2_k127_1767074_26 Fibronectin type III domain protein - - - 0.00000000000000000000000007023 120.0
HFD2_k127_1767074_27 COG1214 Inactive homolog of metal-dependent proteases K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 - 0.000000000000000001102 100.0
HFD2_k127_1767074_28 Protein of unknown function (DUF465) - - - 0.000000001154 62.0
HFD2_k127_1767074_29 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000003021 68.0
HFD2_k127_1767074_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 300.0
HFD2_k127_1767074_30 Metallo-beta-lactamase superfamily - - - 0.0000006095 63.0
HFD2_k127_1767074_31 nuclear chromosome segregation - - - 0.0001035 53.0
HFD2_k127_1767074_32 unfolded protein binding K06142 - - 0.0001122 52.0
HFD2_k127_1767074_4 PFAM sigma-54 factor interaction domain-containing protein K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005814 285.0
HFD2_k127_1767074_5 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003336 282.0
HFD2_k127_1767074_6 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003283 265.0
HFD2_k127_1767074_7 Surface antigen variable number K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001021 273.0
HFD2_k127_1767074_8 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000007445 254.0
HFD2_k127_1767074_9 ABC-type transport system involved in lipoprotein release permease component K02004,K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - 0.0000000000000000000000000000000000000000000000000000000000000000000722 248.0
HFD2_k127_1776269_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000003057 130.0
HFD2_k127_1776269_1 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000001593 101.0
HFD2_k127_1776269_2 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000008783 70.0
HFD2_k127_1776269_3 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0001758 53.0
HFD2_k127_1776916_0 glutamate-tRNA ligase activity K01886 GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 1.326e-251 788.0
HFD2_k127_1776916_1 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 2.041e-198 629.0
HFD2_k127_1776916_10 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 342.0
HFD2_k127_1776916_11 PFAM ribonucleotide reductase K00526 - 1.17.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 311.0
HFD2_k127_1776916_12 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 311.0
HFD2_k127_1776916_13 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000224 266.0
HFD2_k127_1776916_14 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008143 248.0
HFD2_k127_1776916_15 cellulose binding K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000009507 270.0
HFD2_k127_1776916_16 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003194 251.0
HFD2_k127_1776916_17 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005383 241.0
HFD2_k127_1776916_18 DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000001875 219.0
HFD2_k127_1776916_19 Predicted integral membrane protein (DUF2270) - - - 0.000000000000000000000000000000000000000000000002241 181.0
HFD2_k127_1776916_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 575.0
HFD2_k127_1776916_20 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000000001056 158.0
HFD2_k127_1776916_21 FG-GAP repeat - - - 0.00000000000000000001915 106.0
HFD2_k127_1776916_23 RESPONSE REGULATOR receiver - - - 0.00000000229 65.0
HFD2_k127_1776916_24 amine dehydrogenase activity K03641 - - 0.0000001179 64.0
HFD2_k127_1776916_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009583 552.0
HFD2_k127_1776916_4 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 537.0
HFD2_k127_1776916_5 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 490.0
HFD2_k127_1776916_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003435 484.0
HFD2_k127_1776916_7 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 375.0
HFD2_k127_1776916_8 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 380.0
HFD2_k127_1776916_9 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 369.0
HFD2_k127_178539_0 Tricorn protease homolog K08676 - - 0.0 1371.0
HFD2_k127_178539_1 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0 1005.0
HFD2_k127_178539_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 476.0
HFD2_k127_178539_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 427.0
HFD2_k127_178539_4 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 350.0
HFD2_k127_178539_5 PFAM Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000003384 208.0
HFD2_k127_1792682_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 443.0
HFD2_k127_1792682_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine - - - 0.0000000000000000000000000001877 122.0
HFD2_k127_1793170_0 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 526.0
HFD2_k127_1793170_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 519.0
HFD2_k127_1793170_10 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000165 169.0
HFD2_k127_1793170_11 PFAM plasmid K06218 - - 0.00000000000000000008584 91.0
HFD2_k127_1793170_12 - - - - 0.0000000000003194 72.0
HFD2_k127_1793170_14 amine dehydrogenase activity - - - 0.00000000001022 76.0
HFD2_k127_1793170_15 CAAX protease self-immunity K07052 - - 0.0002001 48.0
HFD2_k127_1793170_2 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 453.0
HFD2_k127_1793170_3 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 386.0
HFD2_k127_1793170_4 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 371.0
HFD2_k127_1793170_5 ABC transporter K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 347.0
HFD2_k127_1793170_6 Flavin containing amine oxidoreductase K06955 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 332.0
HFD2_k127_1793170_7 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K01647,K22491 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000116 215.0
HFD2_k127_1793170_8 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000002453 214.0
HFD2_k127_1793170_9 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000005929 200.0
HFD2_k127_1798647_0 Dienelactone hydrolase family - - - 0.0 1153.0
HFD2_k127_1798647_1 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 554.0
HFD2_k127_1798647_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003004 245.0
HFD2_k127_1798647_11 Pyridine nucleotide-disulphide oxidoreductase K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000001343 236.0
HFD2_k127_1798647_12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000006428 226.0
HFD2_k127_1798647_13 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000004903 188.0
HFD2_k127_1798647_14 Uncharacterized conserved protein (DUF2183) - - - 0.000000000000000000000000000000000000000000000006658 186.0
HFD2_k127_1798647_15 - - - - 0.00000000000000000000000000000000004758 149.0
HFD2_k127_1798647_16 - - - - 0.000000000000000000000000000001376 138.0
HFD2_k127_1798647_17 transcriptional regulator - - - 0.0000000000000000000000000004808 132.0
HFD2_k127_1798647_19 - - - - 0.000000000000000000000001346 114.0
HFD2_k127_1798647_2 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 452.0
HFD2_k127_1798647_20 DNA-binding transcription factor activity - - - 0.0000000000000000000006491 113.0
HFD2_k127_1798647_21 6-phosphogluconolactonase activity - - - 0.00000000000000004985 96.0
HFD2_k127_1798647_22 Glycosyl hydrolases family 39 K01198 - 3.2.1.37 0.000000000000003802 91.0
HFD2_k127_1798647_23 isomerase activity - - - 0.000001331 62.0
HFD2_k127_1798647_24 cell adhesion K05889,K17713 - 1.1.2.6 0.000003586 61.0
HFD2_k127_1798647_25 Redoxin - - - 0.0000439 46.0
HFD2_k127_1798647_26 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.0000663 50.0
HFD2_k127_1798647_27 Subtilase family - - - 0.00007049 53.0
HFD2_k127_1798647_28 WD-40 repeat-containing protein - - - 0.0002628 56.0
HFD2_k127_1798647_3 Metal binding domain of Ada K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 399.0
HFD2_k127_1798647_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 371.0
HFD2_k127_1798647_5 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 328.0
HFD2_k127_1798647_6 Conserved protein domain typically associated with flavoprotein oxygenases DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 295.0
HFD2_k127_1798647_7 Histidine kinase K07777 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003551 291.0
HFD2_k127_1798647_8 Wd40 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002559 289.0
HFD2_k127_1798647_9 ATPases associated with a variety of cellular activities K05847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000566 269.0
HFD2_k127_18101_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787,K15726 - - 0.0 1401.0
HFD2_k127_18101_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.5e-323 1022.0
HFD2_k127_18101_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 480.0
HFD2_k127_18101_11 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004718 467.0
HFD2_k127_18101_12 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 430.0
HFD2_k127_18101_13 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 415.0
HFD2_k127_18101_14 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 413.0
HFD2_k127_18101_15 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 399.0
HFD2_k127_18101_16 formate dehydrogenase (NAD+) activity K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 398.0
HFD2_k127_18101_17 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 384.0
HFD2_k127_18101_18 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 377.0
HFD2_k127_18101_19 Alanine-glyoxylate amino-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 370.0
HFD2_k127_18101_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 4.473e-263 839.0
HFD2_k127_18101_20 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006114 372.0
HFD2_k127_18101_21 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 356.0
HFD2_k127_18101_22 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 351.0
HFD2_k127_18101_23 Transmembrane secretion effector K08225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 355.0
HFD2_k127_18101_24 Bacterial regulatory helix-turn-helix protein, lysR family K03717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 348.0
HFD2_k127_18101_25 quinone binding K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007572 346.0
HFD2_k127_18101_26 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 335.0
HFD2_k127_18101_27 Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 341.0
HFD2_k127_18101_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 342.0
HFD2_k127_18101_29 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 357.0
HFD2_k127_18101_3 peptidase S9 prolyl oligopeptidase active site K01303 - 3.4.19.1 1.298e-224 748.0
HFD2_k127_18101_30 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 331.0
HFD2_k127_18101_31 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 326.0
HFD2_k127_18101_32 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 298.0
HFD2_k127_18101_33 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 295.0
HFD2_k127_18101_34 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006669 287.0
HFD2_k127_18101_35 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008465 263.0
HFD2_k127_18101_36 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000003529 257.0
HFD2_k127_18101_37 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001287 279.0
HFD2_k127_18101_38 membrane-anchored protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003681 257.0
HFD2_k127_18101_39 Domains HisKA, HATPase_c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007259 262.0
HFD2_k127_18101_4 PFAM Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 3.639e-216 684.0
HFD2_k127_18101_40 polysaccharide deacetylase K01452 - 3.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000008922 269.0
HFD2_k127_18101_41 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004139 255.0
HFD2_k127_18101_42 Belongs to the beta-ketoacyl-ACP synthases family K05551,K09458 - 2.3.1.179,2.3.1.235,2.3.1.260 0.00000000000000000000000000000000000000000000000000000000000000000002438 249.0
HFD2_k127_18101_43 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000002383 213.0
HFD2_k127_18101_44 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000007337 209.0
HFD2_k127_18101_45 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000002308 203.0
HFD2_k127_18101_46 Metalloenzyme superfamily - - - 0.000000000000000000000000000000000000000000000000001029 195.0
HFD2_k127_18101_47 Cupin - - - 0.00000000000000000000000000000000000000000000000000431 187.0
HFD2_k127_18101_48 Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000000000000000000000000000000000167 187.0
HFD2_k127_18101_49 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000002106 190.0
HFD2_k127_18101_5 PFAM peptidase M61 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 614.0
HFD2_k127_18101_50 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.0000000000000000000000000000000000000000000000003027 195.0
HFD2_k127_18101_51 Protein of unknown function DUF47 K02039,K07220 - - 0.0000000000000000000000000000000000000000000000003153 183.0
HFD2_k127_18101_52 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000001298 182.0
HFD2_k127_18101_53 LexA-binding, inner membrane-associated putative hydrolase - - - 0.000000000000000000000000000000000000000000002903 170.0
HFD2_k127_18101_54 Phospholipase D. Active site motifs. K06132 - - 0.00000000000000000000000000000000000000000001116 187.0
HFD2_k127_18101_55 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000947 173.0
HFD2_k127_18101_56 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000002923 153.0
HFD2_k127_18101_57 bacteriocin transport K03561 - - 0.000000000000000000000000000000000004986 144.0
HFD2_k127_18101_58 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000000001446 149.0
HFD2_k127_18101_6 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 598.0
HFD2_k127_18101_60 ACT domain K09707 - - 0.000000000000000000000000000000003556 133.0
HFD2_k127_18101_61 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000003631 143.0
HFD2_k127_18101_62 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) K00571 - 2.1.1.72 0.0000000000000000000000000000000169 145.0
HFD2_k127_18101_63 Peptidase family M1 domain - - - 0.00000000000000000000000000001123 139.0
HFD2_k127_18101_64 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus K03624,K06140 - - 0.00000000000000000000000000001315 124.0
HFD2_k127_18101_65 cheY-homologous receiver domain - - - 0.0000000000000000000000000000818 122.0
HFD2_k127_18101_66 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.0000000000000000000000000003151 115.0
HFD2_k127_18101_67 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000004019 117.0
HFD2_k127_18101_68 MMPL family K07003 - - 0.000000000000000000000001547 122.0
HFD2_k127_18101_69 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000003548 116.0
HFD2_k127_18101_7 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 574.0
HFD2_k127_18101_70 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000001385 103.0
HFD2_k127_18101_71 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000003996 103.0
HFD2_k127_18101_72 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000005377 100.0
HFD2_k127_18101_73 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.00000000000000005211 97.0
HFD2_k127_18101_74 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000005899 89.0
HFD2_k127_18101_75 Transcriptional regulator - - - 0.0000000000000000829 94.0
HFD2_k127_18101_76 LysR substrate binding domain - - - 0.0000000000000003473 89.0
HFD2_k127_18101_77 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000093 84.0
HFD2_k127_18101_78 Phosphopantetheine attachment site K02078 - - 0.000000000000002874 90.0
HFD2_k127_18101_79 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000002958 85.0
HFD2_k127_18101_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 490.0
HFD2_k127_18101_80 cellulase activity K20276 - - 0.0000000000001563 84.0
HFD2_k127_18101_81 - - - - 0.000000000003659 68.0
HFD2_k127_18101_82 Tetratricopeptide TPR_2 repeat protein K12600 - - 0.00000000006475 76.0
HFD2_k127_18101_83 Parallel beta-helix repeats - - - 0.0000000005532 73.0
HFD2_k127_18101_84 Cytochrome P460 - - - 0.00000001466 64.0
HFD2_k127_18101_85 FabA-like domain - - - 0.00000005481 64.0
HFD2_k127_18101_86 Transcriptional regulator, DeoR family K21601 - - 0.00000005622 61.0
HFD2_k127_18101_87 Yip1 domain - - - 0.0000003904 61.0
HFD2_k127_18101_88 TIGRFAM TonB family protein K03832 - - 0.0000009542 61.0
HFD2_k127_18101_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 490.0
HFD2_k127_18101_90 Biopolymer transport protein K03559 - - 0.0003094 52.0
HFD2_k127_1836487_0 Thrombospondin type 3 repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001402 244.0
HFD2_k127_1836487_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000004619 168.0
HFD2_k127_1836487_2 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000004523 146.0
HFD2_k127_1836487_3 helix_turn_helix, arabinose operon control protein K07720 - - 0.0000000000004681 79.0
HFD2_k127_1836487_4 fumarate reductase K00239 - 1.3.5.1,1.3.5.4 0.00001578 58.0
HFD2_k127_1836487_5 - - - - 0.0004174 53.0
HFD2_k127_1890733_0 Amp-dependent synthetase and ligase K00797,K01897 - 2.5.1.16,6.2.1.3 0.0 1122.0
HFD2_k127_1890733_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 1.661e-274 892.0
HFD2_k127_1890733_10 Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 435.0
HFD2_k127_1890733_11 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 412.0
HFD2_k127_1890733_12 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 409.0
HFD2_k127_1890733_13 synthase K00697,K16055 GO:0003674,GO:0003824,GO:0003825,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0030312,GO:0033554,GO:0034637,GO:0035251,GO:0040007,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0046872,GO:0046914,GO:0047260,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:0071944,GO:1901576 2.4.1.15,2.4.1.347,3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 375.0
HFD2_k127_1890733_14 ABC transporter, transmembrane region K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 376.0
HFD2_k127_1890733_15 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 371.0
HFD2_k127_1890733_16 - K12065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 360.0
HFD2_k127_1890733_17 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 359.0
HFD2_k127_1890733_18 PFAM Transglycosylase SLT domain K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 349.0
HFD2_k127_1890733_19 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 327.0
HFD2_k127_1890733_2 Oligoendopeptidase f - - - 8.451e-222 712.0
HFD2_k127_1890733_20 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 330.0
HFD2_k127_1890733_21 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 317.0
HFD2_k127_1890733_22 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007228 314.0
HFD2_k127_1890733_23 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 314.0
HFD2_k127_1890733_24 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 325.0
HFD2_k127_1890733_25 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 306.0
HFD2_k127_1890733_26 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 316.0
HFD2_k127_1890733_27 PFAM Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 321.0
HFD2_k127_1890733_28 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001575 300.0
HFD2_k127_1890733_29 Zn_pept K05996 - 3.4.17.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000007293 293.0
HFD2_k127_1890733_3 ABC transporter K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 571.0
HFD2_k127_1890733_30 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003954 273.0
HFD2_k127_1890733_31 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000004432 253.0
HFD2_k127_1890733_32 selenocysteine lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000001489 237.0
HFD2_k127_1890733_33 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000002926 236.0
HFD2_k127_1890733_34 membrane K08981 - - 0.000000000000000000000000000000000000000000000000000000000000004162 239.0
HFD2_k127_1890733_35 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000008622 234.0
HFD2_k127_1890733_36 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000001428 218.0
HFD2_k127_1890733_37 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000005093 239.0
HFD2_k127_1890733_38 PFAM Silent information regulator protein Sir2 K12410 - - 0.0000000000000000000000000000000000000000000000000000000001142 223.0
HFD2_k127_1890733_39 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000005935 218.0
HFD2_k127_1890733_4 DNA polymerase K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 561.0
HFD2_k127_1890733_40 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000008674 203.0
HFD2_k127_1890733_41 HhH-GPD superfamily base excision DNA repair protein - - - 0.000000000000000000000000000000000000000000000000000001315 214.0
HFD2_k127_1890733_42 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000455 192.0
HFD2_k127_1890733_43 FIST C domain - GO:0008150,GO:0040007 - 0.000000000000000000000000000000000000000000000000006738 197.0
HFD2_k127_1890733_44 pseudouridine synthase activity K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000007008 204.0
HFD2_k127_1890733_45 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000004098 189.0
HFD2_k127_1890733_46 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000003329 179.0
HFD2_k127_1890733_47 LytTr DNA-binding domain K02477,K07705,K21696 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.0000000000000000000000000000000000000000000008342 187.0
HFD2_k127_1890733_48 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000000000000002993 169.0
HFD2_k127_1890733_49 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000008112 171.0
HFD2_k127_1890733_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 506.0
HFD2_k127_1890733_50 Methyltransferase domain K00588 - 2.1.1.104 0.000000000000000000000000000000000000000000132 167.0
HFD2_k127_1890733_51 Diacylglycerol kinase K07029 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 0.0000000000000000000000000000000000000000006116 171.0
HFD2_k127_1890733_52 Histidine kinase - - - 0.00000000000000000000000000000000000000001712 172.0
HFD2_k127_1890733_53 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000007382 167.0
HFD2_k127_1890733_54 belongs to the Fur family K03711,K09823,K09825 - - 0.000000000000000000000000000000000003024 143.0
HFD2_k127_1890733_55 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000002188 155.0
HFD2_k127_1890733_56 Ndr family - - - 0.0000000000000000000000000000001265 134.0
HFD2_k127_1890733_57 Thrombospondin type 3 repeat - - - 0.0000000000000000000000000000007227 142.0
HFD2_k127_1890733_58 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000007559 139.0
HFD2_k127_1890733_59 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000009818 131.0
HFD2_k127_1890733_6 Putative citrate transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 503.0
HFD2_k127_1890733_60 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000001433 133.0
HFD2_k127_1890733_61 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000145 134.0
HFD2_k127_1890733_62 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000009107 128.0
HFD2_k127_1890733_63 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000000001989 130.0
HFD2_k127_1890733_64 Tetratricopeptide repeat - - - 0.0000000000000000000000000002368 134.0
HFD2_k127_1890733_65 Transport and Golgi organisation 2 - - - 0.000000000000000000000000001403 126.0
HFD2_k127_1890733_66 Bacterial PH domain K09167 - - 0.0000000000000000000000007559 122.0
HFD2_k127_1890733_67 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000002435 121.0
HFD2_k127_1890733_68 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000003732 118.0
HFD2_k127_1890733_69 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.00000000000000000007915 101.0
HFD2_k127_1890733_7 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 492.0
HFD2_k127_1890733_70 Thioesterase-like superfamily K07107 - - 0.00000000000000001329 95.0
HFD2_k127_1890733_71 EamA-like transporter family - - - 0.00000000000000001984 96.0
HFD2_k127_1890733_72 Ubiquinone biosynthesis protein UbiA K02548 - 2.5.1.74 0.000000000000001604 87.0
HFD2_k127_1890733_73 CarboxypepD_reg-like domain K13276 - - 0.000000000000001925 92.0
HFD2_k127_1890733_74 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000002716 89.0
HFD2_k127_1890733_75 Polymer-forming cytoskeletal - - - 0.0000000000001498 83.0
HFD2_k127_1890733_76 DNA polymerase III K02342 - 2.7.7.7 0.0000000000002422 83.0
HFD2_k127_1890733_77 - - - - 0.0000000000005005 82.0
HFD2_k127_1890733_78 Protein of unknown function (DUF1573) - - - 0.0000000000008824 78.0
HFD2_k127_1890733_79 PFAM peptidase M4 thermolysin - - - 0.00000000000276 81.0
HFD2_k127_1890733_8 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 479.0
HFD2_k127_1890733_81 Belongs to the UPF0235 family K09131 - - 0.00000000004601 75.0
HFD2_k127_1890733_82 Peptidase family M54 K06974 - - 0.00000000006389 70.0
HFD2_k127_1890733_84 alpha beta hydrolase fold - - - 0.0000007793 59.0
HFD2_k127_1890733_85 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000001676 59.0
HFD2_k127_1890733_86 peroxiredoxin activity K03564 - 1.11.1.15 0.000002636 53.0
HFD2_k127_1890733_87 membrane protein, required for colicin V production K03558 - - 0.00001949 54.0
HFD2_k127_1890733_88 Putative zinc-finger - - - 0.0002093 53.0
HFD2_k127_1890733_9 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 442.0
HFD2_k127_1917749_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 5e-323 1002.0
HFD2_k127_1917749_1 Transketolase, central region K00615 - 2.2.1.1 4.952e-273 880.0
HFD2_k127_1917749_10 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 361.0
HFD2_k127_1917749_11 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 357.0
HFD2_k127_1917749_12 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 336.0
HFD2_k127_1917749_13 Sodium:solute symporter family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 321.0
HFD2_k127_1917749_14 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008873 277.0
HFD2_k127_1917749_15 DNA polymerase III subunit epsilon K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000787 249.0
HFD2_k127_1917749_16 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000001497 189.0
HFD2_k127_1917749_17 heme binding K08259 - 3.4.24.75 0.00000000000000000000000000000000000000000282 175.0
HFD2_k127_1917749_18 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.00000000000000000000000000000000000000000364 179.0
HFD2_k127_1917749_19 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000001022 171.0
HFD2_k127_1917749_2 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 2.173e-227 730.0
HFD2_k127_1917749_20 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000194 170.0
HFD2_k127_1917749_21 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000001082 153.0
HFD2_k127_1917749_22 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000002563 155.0
HFD2_k127_1917749_24 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000151 96.0
HFD2_k127_1917749_25 PKD domain - - - 0.000000000000003277 90.0
HFD2_k127_1917749_26 PDZ DHR GLGF domain protein - - - 0.0000000000002734 85.0
HFD2_k127_1917749_27 cellulase activity K01387 - 3.4.24.3 0.000000000003381 80.0
HFD2_k127_1917749_28 - - - - 0.0000000001248 73.0
HFD2_k127_1917749_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.317e-196 632.0
HFD2_k127_1917749_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 552.0
HFD2_k127_1917749_5 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 547.0
HFD2_k127_1917749_6 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 509.0
HFD2_k127_1917749_7 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 478.0
HFD2_k127_1917749_8 PFAM aminotransferase, class I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 396.0
HFD2_k127_1917749_9 PFAM Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 402.0
HFD2_k127_1945209_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.0 1268.0
HFD2_k127_1945209_1 Sigma-70 region 2 - - - 1.243e-194 614.0
HFD2_k127_1945209_10 MerR, DNA binding K13639 - - 0.000000000000000000000000000000000000000000000000000000000000401 223.0
HFD2_k127_1945209_11 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000000000000191 209.0
HFD2_k127_1945209_12 Uncharacterised protein family UPF0066 K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000006619 193.0
HFD2_k127_1945209_13 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000007398 194.0
HFD2_k127_1945209_14 Doxx family K15977 - - 0.0000000000000000000000000000000000000000002199 165.0
HFD2_k127_1945209_15 YCII-related domain - - - 0.000000000000000000000000000000905 128.0
HFD2_k127_1945209_16 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.00000000000000000000004761 107.0
HFD2_k127_1945209_17 Dodecin K09165 - - 0.000000000000000000001252 95.0
HFD2_k127_1945209_18 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.7 0.000000000000000002139 87.0
HFD2_k127_1945209_19 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K05970 - 3.1.1.53 0.00000000009954 76.0
HFD2_k127_1945209_2 RNA polymerase sigma factor containing a TPR repeat domain K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 469.0
HFD2_k127_1945209_20 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00001055 59.0
HFD2_k127_1945209_21 - - - - 0.00006284 55.0
HFD2_k127_1945209_3 Queuosine biosynthesis protein K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 423.0
HFD2_k127_1945209_4 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 419.0
HFD2_k127_1945209_5 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 344.0
HFD2_k127_1945209_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 304.0
HFD2_k127_1945209_7 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005316 282.0
HFD2_k127_1945209_8 Protein of unknown function (DUF541) K09797 - - 0.00000000000000000000000000000000000000000000000000000000000000004979 229.0
HFD2_k127_1945209_9 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000001482 219.0
HFD2_k127_1962669_0 Peptidase, family M49 - - - 2.918e-202 660.0
HFD2_k127_1962669_1 4Fe-4S dicluster domain - - - 7.239e-194 632.0
HFD2_k127_1962669_10 PFAM ATPase associated with various cellular activities, AAA_5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 331.0
HFD2_k127_1962669_11 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 323.0
HFD2_k127_1962669_12 Cephalosporin hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 319.0
HFD2_k127_1962669_13 TIGRFAM Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 322.0
HFD2_k127_1962669_14 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147 GO:0000175,GO:0000178,GO:0000932,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0022613,GO:0032991,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0035770,GO:0036464,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354,GO:1990904 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000009022 280.0
HFD2_k127_1962669_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001264 235.0
HFD2_k127_1962669_16 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000003603 209.0
HFD2_k127_1962669_17 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000009158 211.0
HFD2_k127_1962669_18 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000003538 210.0
HFD2_k127_1962669_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000002507 188.0
HFD2_k127_1962669_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 537.0
HFD2_k127_1962669_20 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000007734 175.0
HFD2_k127_1962669_21 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000003484 165.0
HFD2_k127_1962669_22 PIN domain K07062 - - 0.0000000000000000000000000000000000000007724 155.0
HFD2_k127_1962669_23 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.000000000000000000000000000000000000001159 153.0
HFD2_k127_1962669_24 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000005568 158.0
HFD2_k127_1962669_25 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000002055 121.0
HFD2_k127_1962669_26 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000008321 125.0
HFD2_k127_1962669_27 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000002958 129.0
HFD2_k127_1962669_28 Belongs to the UPF0102 family K07460 - - 0.00000000000000000005441 104.0
HFD2_k127_1962669_29 nitrite reductase [NAD(P)H] activity K00363,K05710 - 1.7.1.15 0.00000000000000008369 95.0
HFD2_k127_1962669_3 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 496.0
HFD2_k127_1962669_30 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000006098 69.0
HFD2_k127_1962669_31 - - - - 0.000000001749 66.0
HFD2_k127_1962669_32 Calcineurin-like phosphoesterase - - - 0.00000005413 67.0
HFD2_k127_1962669_33 Peptidase M56 - - - 0.0000002214 64.0
HFD2_k127_1962669_34 - - - - 0.0000006355 52.0
HFD2_k127_1962669_35 Carboxypeptidase regulatory-like domain - - - 0.000007421 57.0
HFD2_k127_1962669_37 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0007529 46.0
HFD2_k127_1962669_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 487.0
HFD2_k127_1962669_5 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 473.0
HFD2_k127_1962669_6 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 446.0
HFD2_k127_1962669_7 C-methyltransferase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 427.0
HFD2_k127_1962669_8 CDP-glucose 4,6-dehydratase K01709 - 4.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 376.0
HFD2_k127_1962669_9 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 357.0
HFD2_k127_1977619_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.221e-309 960.0
HFD2_k127_1977619_1 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 8.469e-296 932.0
HFD2_k127_1977619_10 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000008697 234.0
HFD2_k127_1977619_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K20444 - - 0.0000000000000000000000000000000000000000000000000000001276 211.0
HFD2_k127_1977619_12 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001239 179.0
HFD2_k127_1977619_13 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000003244 156.0
HFD2_k127_1977619_14 Protein of unknown function (DUF1622) - - - 0.000000000000000000000008235 107.0
HFD2_k127_1977619_15 YfaZ precursor - - - 0.000000000000000002822 94.0
HFD2_k127_1977619_16 - - - - 0.000000000008271 77.0
HFD2_k127_1977619_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000105 74.0
HFD2_k127_1977619_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 1.352e-255 800.0
HFD2_k127_1977619_3 Polysulphide reductase, NrfD K00185 - - 2.722e-215 674.0
HFD2_k127_1977619_4 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 536.0
HFD2_k127_1977619_5 polyphosphate kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 485.0
HFD2_k127_1977619_6 major pilin protein fima - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008743 342.0
HFD2_k127_1977619_7 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 320.0
HFD2_k127_1977619_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 288.0
HFD2_k127_1977619_9 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003108 258.0
HFD2_k127_2059274_0 Berberine and berberine like - - - 5.105e-222 697.0
HFD2_k127_2059274_1 transcription factor binding K02584 - - 1.687e-221 698.0
HFD2_k127_2059274_10 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004674 268.0
HFD2_k127_2059274_11 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008238 245.0
HFD2_k127_2059274_12 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000439 248.0
HFD2_k127_2059274_13 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000002027 241.0
HFD2_k127_2059274_14 Protein of unknown function (DUF1348) K09958 - - 0.0000000000000000000000000000000000000000000000000000000000000003165 222.0
HFD2_k127_2059274_15 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006367 231.0
HFD2_k127_2059274_16 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000005946 201.0
HFD2_k127_2059274_17 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000002129 184.0
HFD2_k127_2059274_18 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000000000000000000000003073 171.0
HFD2_k127_2059274_19 ECF sigma factor - - - 0.00000000000000000000000000000000000000000005735 170.0
HFD2_k127_2059274_2 L-asparaginase K01424 - 3.5.1.1 8.883e-202 638.0
HFD2_k127_2059274_20 Low molecular weight phosphotyrosine protein phosphatase - - - 0.00000000000000000000000000000000000008605 147.0
HFD2_k127_2059274_21 AraC-like ligand binding domain - - - 0.0000000000000000000000000000000000002458 144.0
HFD2_k127_2059274_22 peroxiredoxin activity - - - 0.0000000000000000000000000000000000007354 147.0
HFD2_k127_2059274_23 monooxygenase activity - - - 0.00000000000000000000000000000001682 136.0
HFD2_k127_2059274_24 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000337 129.0
HFD2_k127_2059274_25 LICD family - - - 0.0000000000000000000000000000001774 139.0
HFD2_k127_2059274_27 - - - - 0.000000000000000000000004675 109.0
HFD2_k127_2059274_28 Helix-turn-helix XRE-family like proteins K07729 - - 0.00000000000000001621 84.0
HFD2_k127_2059274_29 - - - - 0.00000000006032 74.0
HFD2_k127_2059274_3 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 534.0
HFD2_k127_2059274_30 YCII-related domain - - - 0.000000002169 64.0
HFD2_k127_2059274_31 Autotransporter beta-domain - - - 0.000000006449 68.0
HFD2_k127_2059274_32 Sigma-70 region 2 K03088 - - 0.00001077 50.0
HFD2_k127_2059274_33 Putative DNA-binding domain - - - 0.00001105 57.0
HFD2_k127_2059274_34 outer membrane protein W K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00003204 55.0
HFD2_k127_2059274_35 Domain of unknown function (DUF4956) - - - 0.00006565 56.0
HFD2_k127_2059274_4 GatB/GatE catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 453.0
HFD2_k127_2059274_5 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000066 379.0
HFD2_k127_2059274_6 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 353.0
HFD2_k127_2059274_7 Xylose isomerase domain protein TIM barrel K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 328.0
HFD2_k127_2059274_8 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003926 301.0
HFD2_k127_2059274_9 PLD-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004017 281.0
HFD2_k127_2084688_0 PFAM AAA ATPase central domain protein K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 480.0
HFD2_k127_2084688_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000003443 140.0
HFD2_k127_2084688_2 - - - - 0.000000001998 61.0
HFD2_k127_208549_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000003583 244.0
HFD2_k127_208549_1 helix_turn_helix, Lux Regulon - - - 0.00001949 49.0
HFD2_k127_208549_2 cellulase activity K20276 - - 0.00008598 54.0
HFD2_k127_2137366_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1016.0
HFD2_k127_2137366_1 aconitate hydratase activity K01681 - 4.2.1.3 2.08e-310 982.0
HFD2_k127_2137366_10 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000958 265.0
HFD2_k127_2137366_11 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000003941 242.0
HFD2_k127_2137366_12 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000002478 192.0
HFD2_k127_2137366_13 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000003021 186.0
HFD2_k127_2137366_14 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000006477 167.0
HFD2_k127_2137366_15 protein involved in formation of curli polymers - - - 0.000000000000000000000000000000000000000003457 169.0
HFD2_k127_2137366_16 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000003343 157.0
HFD2_k127_2137366_17 PFAM Universal stress protein family K06149 - - 0.0000000000000000001108 95.0
HFD2_k127_2137366_18 PFAM cyclic nucleotide-binding - - - 0.0000000000005539 77.0
HFD2_k127_2137366_2 Insulinase (Peptidase family M16) K07263 - - 1.308e-216 710.0
HFD2_k127_2137366_3 Carbon starvation protein K06200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 559.0
HFD2_k127_2137366_4 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006143 578.0
HFD2_k127_2137366_5 NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 535.0
HFD2_k127_2137366_6 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009725 448.0
HFD2_k127_2137366_7 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 439.0
HFD2_k127_2137366_8 Trypsin K08070 - 1.3.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 383.0
HFD2_k127_2137366_9 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 339.0
HFD2_k127_2201552_0 DEAD DEAH box helicase domain protein K06877 - - 1.535e-280 893.0
HFD2_k127_2201552_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 518.0
HFD2_k127_2201552_10 Belongs to the bacterial histone-like protein family K03530 - - 0.00000000000000000005997 92.0
HFD2_k127_2201552_11 peptidase - - - 0.0000000000000000007333 100.0
HFD2_k127_2201552_12 regulatory protein, FmdB family - - - 0.00000000000000001413 88.0
HFD2_k127_2201552_13 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.0000000002919 64.0
HFD2_k127_2201552_14 TonB dependent receptor K02014 - - 0.0006455 53.0
HFD2_k127_2201552_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 454.0
HFD2_k127_2201552_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 462.0
HFD2_k127_2201552_4 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 409.0
HFD2_k127_2201552_5 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000004601 282.0
HFD2_k127_2201552_6 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000001437 142.0
HFD2_k127_2201552_7 Outer membrane receptor for ferrienterochelin and colicins - - - 0.000000000000000000000000000005484 134.0
HFD2_k127_2201552_8 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000415 125.0
HFD2_k127_2201552_9 cellular component assembly - - - 0.000000000000000000001625 108.0
HFD2_k127_2264011_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 409.0
HFD2_k127_2264011_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000001403 70.0
HFD2_k127_2264011_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000197 63.0
HFD2_k127_2264011_3 Serine threonine protein kinase - - - 0.0002477 48.0
HFD2_k127_2399413_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 428.0
HFD2_k127_2399413_1 SpoIVB peptidase S55 K00973,K02414,K21449 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 322.0
HFD2_k127_2399413_2 gluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000000000003323 222.0
HFD2_k127_2399413_3 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000001146 72.0
HFD2_k127_2621360_0 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 492.0
HFD2_k127_2621360_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 477.0
HFD2_k127_2645166_0 - - - - 0.0002269 53.0
HFD2_k127_266013_0 Conserved repeat domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006071 348.0
HFD2_k127_266013_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000006724 157.0
HFD2_k127_266013_2 transposase activity - - - 0.0000000000000000000000000000000000001252 149.0
HFD2_k127_266013_3 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000005856 127.0
HFD2_k127_266013_5 Protein conserved in bacteria K15539 - - 0.000000000002829 75.0
HFD2_k127_266013_7 Pfam:DUF1311 - - - 0.0001816 53.0
HFD2_k127_266013_8 WD40 repeats - - - 0.0002997 54.0
HFD2_k127_2669521_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 552.0
HFD2_k127_2669521_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 559.0
HFD2_k127_2669521_10 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 356.0
HFD2_k127_2669521_11 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 361.0
HFD2_k127_2669521_12 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 357.0
HFD2_k127_2669521_13 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006831 319.0
HFD2_k127_2669521_14 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007861 317.0
HFD2_k127_2669521_15 protein involved in exopolysaccharide biosynthesis K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 319.0
HFD2_k127_2669521_16 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000001867 271.0
HFD2_k127_2669521_17 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003383 254.0
HFD2_k127_2669521_18 Peptidase C26 K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000001224 254.0
HFD2_k127_2669521_19 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000001056 246.0
HFD2_k127_2669521_2 UDP binding domain K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 539.0
HFD2_k127_2669521_20 asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000002825 246.0
HFD2_k127_2669521_21 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000002266 231.0
HFD2_k127_2669521_22 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000007389 237.0
HFD2_k127_2669521_23 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000008618 237.0
HFD2_k127_2669521_24 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000002605 226.0
HFD2_k127_2669521_25 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000002113 203.0
HFD2_k127_2669521_26 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000024 207.0
HFD2_k127_2669521_27 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000006073 190.0
HFD2_k127_2669521_28 protein conserved in bacteria K09778 - - 0.000000000000000000000000000000000000000000000000004577 189.0
HFD2_k127_2669521_29 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000001213 196.0
HFD2_k127_2669521_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005545 507.0
HFD2_k127_2669521_30 3-dehydroquinate dehydratase activity K00014,K03785,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0042537,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.1.25,4.2.1.10 0.00000000000000000000000000000000000000000000007466 188.0
HFD2_k127_2669521_31 family 9 - - - 0.0000000000000000000000000000000000000000000001289 188.0
HFD2_k127_2669521_32 purine-nucleoside phosphorylase activity K03783 GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 0.00000000000000000000000000000000000000000001164 188.0
HFD2_k127_2669521_33 Protein conserved in bacteria K06320,K20444 - - 0.0000000000000000000000000000000000000004968 164.0
HFD2_k127_2669521_34 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000008881 152.0
HFD2_k127_2669521_36 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000004276 113.0
HFD2_k127_2669521_37 MlaD protein K02067 - - 0.0000000000000000000004396 109.0
HFD2_k127_2669521_38 Glycosyltransferase Family 4 - - - 0.00000000000000001923 95.0
HFD2_k127_2669521_39 polysaccharide biosynthetic process - - - 0.000000000000001916 90.0
HFD2_k127_2669521_4 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 487.0
HFD2_k127_2669521_40 O-Antigen ligase K02847 - - 0.000000000000002402 89.0
HFD2_k127_2669521_41 - - - - 0.000000000007056 78.0
HFD2_k127_2669521_42 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.00005622 48.0
HFD2_k127_2669521_5 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 478.0
HFD2_k127_2669521_6 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 435.0
HFD2_k127_2669521_7 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 416.0
HFD2_k127_2669521_8 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 414.0
HFD2_k127_2669521_9 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 372.0
HFD2_k127_2680375_0 FAD linked oxidases, C-terminal domain K18930 - - 0.0 1027.0
HFD2_k127_2680375_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.263e-313 992.0
HFD2_k127_2680375_10 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 288.0
HFD2_k127_2680375_11 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001004 286.0
HFD2_k127_2680375_12 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000749 263.0
HFD2_k127_2680375_13 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003747 278.0
HFD2_k127_2680375_14 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703,K20452 - 4.2.1.33,4.2.1.35,4.2.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000004204 266.0
HFD2_k127_2680375_15 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000001787 225.0
HFD2_k127_2680375_16 Hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000000000000000000000000000004877 225.0
HFD2_k127_2680375_17 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000001405 217.0
HFD2_k127_2680375_18 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000008486 192.0
HFD2_k127_2680375_19 AAA domain - - - 0.000000000000000000000000000000000000000000000001189 183.0
HFD2_k127_2680375_2 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 1.864e-216 681.0
HFD2_k127_2680375_20 Domain of unknown function (DUF4126) - - - 0.00000000000000000000000000000000000000000000004188 176.0
HFD2_k127_2680375_21 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000001098 175.0
HFD2_k127_2680375_22 Acyl-transferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000009791 162.0
HFD2_k127_2680375_23 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000009919 153.0
HFD2_k127_2680375_24 TIGRFAM Transcriptional regulator, Rrf2 - - - 0.000000000000000000000000004561 118.0
HFD2_k127_2680375_25 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000002368 97.0
HFD2_k127_2680375_26 Bacterial Ig-like domain (group 1) - - - 0.00000000000000005493 99.0
HFD2_k127_2680375_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 1.422e-211 697.0
HFD2_k127_2680375_4 IrrE N-terminal-like domain K07110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 469.0
HFD2_k127_2680375_5 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 465.0
HFD2_k127_2680375_6 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 437.0
HFD2_k127_2680375_7 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 391.0
HFD2_k127_2680375_8 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 376.0
HFD2_k127_2680375_9 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 321.0
HFD2_k127_2714116_0 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 370.0
HFD2_k127_2714116_1 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 331.0
HFD2_k127_2714116_2 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 331.0
HFD2_k127_2714116_3 mannose metabolic process - - - 0.000000000000000000000000000000000000000000000000000000000008207 237.0
HFD2_k127_2714116_4 Subtilase family - - - 0.00000000000000000000000000001572 138.0
HFD2_k127_2714116_5 COG3209 Rhs family protein - - - 0.000000000000000002111 102.0
HFD2_k127_2744855_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 614.0
HFD2_k127_2744855_1 PFAM peptidase M3A and M3B thimet oligopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 584.0
HFD2_k127_2744855_10 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 296.0
HFD2_k127_2744855_11 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000262 288.0
HFD2_k127_2744855_12 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001631 280.0
HFD2_k127_2744855_13 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000004258 213.0
HFD2_k127_2744855_14 - - - - 0.00000000000000000000000000000000000007925 163.0
HFD2_k127_2744855_15 PFAM OsmC family protein K09136 - - 0.0000000000000000000000000000004949 127.0
HFD2_k127_2744855_16 - - - - 0.00000000000000000000000000004157 130.0
HFD2_k127_2744855_17 PspC domain - - - 0.000000000000006144 76.0
HFD2_k127_2744855_18 - - - - 0.0000000006514 72.0
HFD2_k127_2744855_19 - - - - 0.00000002301 61.0
HFD2_k127_2744855_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 533.0
HFD2_k127_2744855_20 ADP binding - - - 0.000005523 59.0
HFD2_k127_2744855_21 Kazal-type serine protease inhibitor domain - - - 0.00002735 50.0
HFD2_k127_2744855_22 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0003659 50.0
HFD2_k127_2744855_23 Cupin 2, conserved barrel domain protein - - - 0.0004823 52.0
HFD2_k127_2744855_3 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 460.0
HFD2_k127_2744855_4 Permease family K06901 GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 447.0
HFD2_k127_2744855_5 oligopeptide transport K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 455.0
HFD2_k127_2744855_6 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005674 389.0
HFD2_k127_2744855_7 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 385.0
HFD2_k127_2744855_8 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 402.0
HFD2_k127_2744855_9 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 359.0
HFD2_k127_2753832_0 adenylosuccinate lyase K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 504.0
HFD2_k127_2753832_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000003972 148.0
HFD2_k127_2753832_2 - - - - 0.000000003612 61.0
HFD2_k127_275695_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 2.817e-241 767.0
HFD2_k127_275695_1 oligopeptide transport K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 303.0
HFD2_k127_275695_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000003515 229.0
HFD2_k127_275695_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000006701 226.0
HFD2_k127_275695_4 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000001347 208.0
HFD2_k127_275695_5 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000000000004691 197.0
HFD2_k127_275695_6 CYTH - - - 0.000000000000000000000000000000000000000000000116 178.0
HFD2_k127_275695_7 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000001092 144.0
HFD2_k127_275695_8 DNA-templated transcription, initiation K03088 - - 0.000000000003041 74.0
HFD2_k127_2760208_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 3.246e-319 999.0
HFD2_k127_2760208_1 Heat shock 70 kDa protein K04043 - - 3.52e-287 894.0
HFD2_k127_2760208_10 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 367.0
HFD2_k127_2760208_11 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 329.0
HFD2_k127_2760208_12 PFAM ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 312.0
HFD2_k127_2760208_13 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 308.0
HFD2_k127_2760208_14 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008187 307.0
HFD2_k127_2760208_15 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000982 303.0
HFD2_k127_2760208_16 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004406 293.0
HFD2_k127_2760208_17 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000109 290.0
HFD2_k127_2760208_18 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006903 277.0
HFD2_k127_2760208_19 GTP binding K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006355 274.0
HFD2_k127_2760208_2 PFAM Methylmalonyl-CoA mutase K01848 - 5.4.99.2 2.426e-232 731.0
HFD2_k127_2760208_20 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006362 276.0
HFD2_k127_2760208_21 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000007864 282.0
HFD2_k127_2760208_22 Electron transfer flavoprotein FAD-binding domain K03522 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001172 273.0
HFD2_k127_2760208_23 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000003464 251.0
HFD2_k127_2760208_24 transport system involved in gliding motility, auxiliary K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000001176 255.0
HFD2_k127_2760208_25 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000002128 259.0
HFD2_k127_2760208_26 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000005218 237.0
HFD2_k127_2760208_27 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000003168 233.0
HFD2_k127_2760208_28 Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000001025 227.0
HFD2_k127_2760208_29 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000000000002325 238.0
HFD2_k127_2760208_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008692 532.0
HFD2_k127_2760208_30 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000009078 215.0
HFD2_k127_2760208_31 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000005084 208.0
HFD2_k127_2760208_32 purine ribonucleoside salvage K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000001279 186.0
HFD2_k127_2760208_33 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000008052 187.0
HFD2_k127_2760208_34 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000008015 170.0
HFD2_k127_2760208_35 IstB-like ATP binding protein K02315,K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000008251 173.0
HFD2_k127_2760208_36 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000001307 156.0
HFD2_k127_2760208_37 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000004221 140.0
HFD2_k127_2760208_38 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000007789 150.0
HFD2_k127_2760208_39 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.000000000000000000000000000000001844 133.0
HFD2_k127_2760208_4 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008628 455.0
HFD2_k127_2760208_40 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000000621 135.0
HFD2_k127_2760208_41 sensor histidine kinase response - - - 0.00000000000000000000000000000004905 146.0
HFD2_k127_2760208_42 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000001509 142.0
HFD2_k127_2760208_43 Peptidase family M50 - - - 0.000000000000000000000000000006329 138.0
HFD2_k127_2760208_44 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000000000002817 120.0
HFD2_k127_2760208_45 low molecular weight K01104,K20201 - 3.1.3.48,3.9.1.2 0.0000000000000000000000001283 120.0
HFD2_k127_2760208_46 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.000000000000000000000000196 110.0
HFD2_k127_2760208_47 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000001181 111.0
HFD2_k127_2760208_48 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000283 104.0
HFD2_k127_2760208_49 Regulatory protein - - - 0.00000000000000000000004511 109.0
HFD2_k127_2760208_5 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004963 439.0
HFD2_k127_2760208_51 phosphocarrier protein hpr K08485,K11189 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - 0.000000000000000001049 100.0
HFD2_k127_2760208_52 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.000000000000000009599 96.0
HFD2_k127_2760208_53 Domain of unknown function (DUF1844) - - - 0.0000000000000004993 85.0
HFD2_k127_2760208_54 Domain of unknown function (DUF4388) - - - 0.000000000006822 80.0
HFD2_k127_2760208_55 peptidyl-tyrosine sulfation - - - 0.00000000004388 75.0
HFD2_k127_2760208_57 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000003934 63.0
HFD2_k127_2760208_58 Virulence factor BrkB K07058 - - 0.0000006722 63.0
HFD2_k127_2760208_59 Domain of unknown function (DUF4340) - - - 0.000001237 61.0
HFD2_k127_2760208_6 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 411.0
HFD2_k127_2760208_60 peptidyl-tyrosine sulfation - - - 0.00001562 57.0
HFD2_k127_2760208_62 Belongs to the 'phage' integrase family - - - 0.0006817 46.0
HFD2_k127_2760208_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 392.0
HFD2_k127_2760208_8 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 368.0
HFD2_k127_2760208_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 370.0
HFD2_k127_2774756_0 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004707 595.0
HFD2_k127_2774756_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 443.0
HFD2_k127_2774756_2 DNA RNA helicase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 407.0
HFD2_k127_2774756_3 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006963 273.0
HFD2_k127_278294_0 PFAM Na-Ca exchanger integrin-beta4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 384.0
HFD2_k127_278294_1 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000005138 231.0
HFD2_k127_278294_10 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0003645 53.0
HFD2_k127_278294_2 Glyoxalase-like domain K07032 - - 0.000000000000000000000000000000000000000000000000000224 195.0
HFD2_k127_278294_3 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000001809 176.0
HFD2_k127_278294_4 regulation of methylation-dependent chromatin silencing - - - 0.0000000000000000000000000004197 117.0
HFD2_k127_278294_5 Beta-xylanase K01181 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010383,GO:0010410,GO:0016052,GO:0016787,GO:0016798,GO:0030312,GO:0031176,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0045491,GO:0045493,GO:0071554,GO:0071704,GO:0071944,GO:0097599,GO:1901575 3.2.1.8 0.0000000000000000000000001651 124.0
HFD2_k127_278294_6 Sulfurtransferase TusA K04085 - - 0.00000000000000005561 83.0
HFD2_k127_278294_7 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.0000000000004617 81.0
HFD2_k127_278294_8 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000002756 73.0
HFD2_k127_278294_9 - - - - 0.00008226 45.0
HFD2_k127_2783550_0 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 576.0
HFD2_k127_2783550_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 484.0
HFD2_k127_2783550_10 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000008226 216.0
HFD2_k127_2783550_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000001705 199.0
HFD2_k127_2783550_12 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000005666 190.0
HFD2_k127_2783550_13 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000008116 190.0
HFD2_k127_2783550_14 histidine kinase HAMP region domain protein K03406 - - 0.0000000000000000000000000000000000008967 155.0
HFD2_k127_2783550_15 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000004245 139.0
HFD2_k127_2783550_16 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino- 5-hydroxymethyl-2-methylpyrimidine (HMP) K20896 - - 0.0000000000000000000000000000008696 130.0
HFD2_k127_2783550_17 Transmembrane and TPR repeat-containing protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827 - 0.00000000000000000000000001692 127.0
HFD2_k127_2783550_18 - - - - 0.00000000009569 72.0
HFD2_k127_2783550_19 von Willebrand factor, type A K07114 - - 0.0000000004559 72.0
HFD2_k127_2783550_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 427.0
HFD2_k127_2783550_20 peptidyl-tyrosine sulfation - - - 0.00000000825 70.0
HFD2_k127_2783550_21 Putative adhesin - - - 0.0002709 54.0
HFD2_k127_2783550_3 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 434.0
HFD2_k127_2783550_4 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 319.0
HFD2_k127_2783550_5 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002252 300.0
HFD2_k127_2783550_6 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007755 283.0
HFD2_k127_2783550_7 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001263 258.0
HFD2_k127_2783550_8 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000001101 213.0
HFD2_k127_2783550_9 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000005657 202.0
HFD2_k127_2807519_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1166.0
HFD2_k127_2807519_1 Peptidase dimerisation domain - - - 5.247e-256 796.0
HFD2_k127_2807519_10 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 475.0
HFD2_k127_2807519_11 Ankyrin repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 456.0
HFD2_k127_2807519_12 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 453.0
HFD2_k127_2807519_13 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 441.0
HFD2_k127_2807519_14 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 423.0
HFD2_k127_2807519_15 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 396.0
HFD2_k127_2807519_16 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 388.0
HFD2_k127_2807519_17 SMART Tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 393.0
HFD2_k127_2807519_18 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K00256 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 370.0
HFD2_k127_2807519_19 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 365.0
HFD2_k127_2807519_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 2.336e-236 754.0
HFD2_k127_2807519_20 Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 360.0
HFD2_k127_2807519_21 COG3209 Rhs family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 360.0
HFD2_k127_2807519_22 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 347.0
HFD2_k127_2807519_23 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 330.0
HFD2_k127_2807519_24 PFAM lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 329.0
HFD2_k127_2807519_25 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 308.0
HFD2_k127_2807519_26 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005032 295.0
HFD2_k127_2807519_27 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002133 290.0
HFD2_k127_2807519_28 Ketopantoate reductase PanE/ApbA C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006905 279.0
HFD2_k127_2807519_29 Cytochrome b(N-terminal)/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006228 275.0
HFD2_k127_2807519_3 SMART Elongator protein 3 MiaB NifB - - - 5.724e-227 719.0
HFD2_k127_2807519_30 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008121 252.0
HFD2_k127_2807519_31 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001039 264.0
HFD2_k127_2807519_32 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003313 271.0
HFD2_k127_2807519_33 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000002791 250.0
HFD2_k127_2807519_34 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001801 260.0
HFD2_k127_2807519_35 DoxX-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000007313 229.0
HFD2_k127_2807519_36 - - - - 0.00000000000000000000000000000000000000000000000000000000000000006256 243.0
HFD2_k127_2807519_37 regulatory protein, arsR - - - 0.00000000000000000000000000000000000000000000000000000002167 198.0
HFD2_k127_2807519_38 MerR, DNA binding - - - 0.00000000000000000000000000000000000000000000000000000008576 201.0
HFD2_k127_2807519_39 ubiE/COQ5 methyltransferase family K13623 - - 0.000000000000000000000000000000000000000000000000000003564 209.0
HFD2_k127_2807519_4 Berberine and berberine like - - - 6.182e-215 681.0
HFD2_k127_2807519_40 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000001959 216.0
HFD2_k127_2807519_41 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000004554 188.0
HFD2_k127_2807519_42 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000000000000007956 194.0
HFD2_k127_2807519_43 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000003984 199.0
HFD2_k127_2807519_44 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000000002531 181.0
HFD2_k127_2807519_45 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000003196 185.0
HFD2_k127_2807519_46 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000008821 195.0
HFD2_k127_2807519_47 - - - - 0.000000000000000000000000000000000000000000000001418 190.0
HFD2_k127_2807519_48 Polysaccharide lyase family 4, domain II - - - 0.00000000000000000000000000000000000000000000002892 176.0
HFD2_k127_2807519_49 Cupin domain - - - 0.0000000000000000000000000000000000000000000004504 179.0
HFD2_k127_2807519_5 cellulose binding - - - 9.95e-215 692.0
HFD2_k127_2807519_50 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000001777 174.0
HFD2_k127_2807519_51 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000003611 169.0
HFD2_k127_2807519_52 - - - - 0.0000000000000000000000000000000000000000002097 174.0
HFD2_k127_2807519_53 DoxX - - - 0.00000000000000000000000000000000000000001895 161.0
HFD2_k127_2807519_54 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000006475 168.0
HFD2_k127_2807519_55 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000003898 160.0
HFD2_k127_2807519_56 Protein of unknown function (DUF4199) - - - 0.00000000000000000000000000000000000007523 148.0
HFD2_k127_2807519_57 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000003716 152.0
HFD2_k127_2807519_58 RNA polymerase sigma factor K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000001276 140.0
HFD2_k127_2807519_59 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000005089 148.0
HFD2_k127_2807519_6 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 587.0
HFD2_k127_2807519_60 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000174 131.0
HFD2_k127_2807519_61 - - - - 0.000000000000000000000000000000256 138.0
HFD2_k127_2807519_63 - - - - 0.0000000000000000000000000000004349 130.0
HFD2_k127_2807519_64 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000004069 116.0
HFD2_k127_2807519_65 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000004621 120.0
HFD2_k127_2807519_66 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000203 125.0
HFD2_k127_2807519_67 S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase K13622 - - 0.000000000000000000000002997 109.0
HFD2_k127_2807519_69 2Fe-2S -binding domain protein K18029 - 1.17.2.1 0.0000000000000000002583 100.0
HFD2_k127_2807519_7 Reductase C-terminal K05297 - 1.18.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 567.0
HFD2_k127_2807519_70 LysM domain - - - 0.00000000000000008959 91.0
HFD2_k127_2807519_73 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000002579 87.0
HFD2_k127_2807519_74 helix-turn-helix- domain containing protein, AraC type K07720 - - 0.00000000003006 75.0
HFD2_k127_2807519_75 - - - - 0.0000000002027 74.0
HFD2_k127_2807519_76 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K00256 - 1.3.99.16 0.0000000005909 65.0
HFD2_k127_2807519_77 Protein of unknown function (DUF2662) - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.000000001902 67.0
HFD2_k127_2807519_78 response regulator - - - 0.000000003282 66.0
HFD2_k127_2807519_79 WD40-like Beta Propeller Repeat K03641 - - 0.000000006389 70.0
HFD2_k127_2807519_8 BNR Asp-box repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 544.0
HFD2_k127_2807519_80 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000001373 58.0
HFD2_k127_2807519_81 PspA/IM30 family K03969 - - 0.0000001829 62.0
HFD2_k127_2807519_82 Putative zinc-finger - - - 0.000001371 58.0
HFD2_k127_2807519_83 Glycosyltransferase family 87 K13671 - - 0.00004645 55.0
HFD2_k127_2807519_84 Sigma-54 interaction domain - - - 0.0001698 50.0
HFD2_k127_2807519_9 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 492.0
HFD2_k127_2834576_0 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K01782,K01825 GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 2.637e-267 849.0
HFD2_k127_2834576_1 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00632 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 552.0
HFD2_k127_2834576_2 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 398.0
HFD2_k127_2834576_3 Ethyl tert-butyl ether degradation - - - 0.0000000000000000000000000000000000000000005124 162.0
HFD2_k127_2834576_4 - - - - 0.0000000000000000000000000000000000000004999 166.0
HFD2_k127_2834576_5 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000003907 81.0
HFD2_k127_2897462_0 ammonia-lyase activity K01745 - 4.3.1.3 3.612e-212 669.0
HFD2_k127_2897462_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 335.0
HFD2_k127_2897462_2 HMGL-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 298.0
HFD2_k127_2897462_3 cellulose binding K12132 - 2.7.11.1 0.0000000000000000000000004613 116.0
HFD2_k127_2924209_0 arylsulfatase activity - - - 0.0000000000000000000002596 105.0
HFD2_k127_2924209_1 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000446 88.0
HFD2_k127_2966656_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005138 509.0
HFD2_k127_2966656_1 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000002937 228.0
HFD2_k127_2966656_2 cystathionine gamma-synthase activity K01739,K01740,K01760,K01761 - 2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000002866 189.0
HFD2_k127_2966656_3 oligosaccharyl transferase activity - - - 0.0000000000000000000007282 112.0
HFD2_k127_2966656_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000007838 108.0
HFD2_k127_2966656_6 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000006199 79.0
HFD2_k127_2966656_7 thiolester hydrolase activity - - - 0.000000000009567 76.0
HFD2_k127_2966656_8 cellulase activity - - - 0.00000007274 57.0
HFD2_k127_2966656_9 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.00007794 54.0
HFD2_k127_2969847_0 Putative methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 568.0
HFD2_k127_2969847_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 431.0
HFD2_k127_2969847_10 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000001381 253.0
HFD2_k127_2969847_11 PFAM glycosyl transferase family 9 K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000001773 251.0
HFD2_k127_2969847_12 PFAM response regulator receiver K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000169 230.0
HFD2_k127_2969847_13 Histidine kinase K07644 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000001108 215.0
HFD2_k127_2969847_14 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000004303 205.0
HFD2_k127_2969847_15 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000002735 182.0
HFD2_k127_2969847_16 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000007571 183.0
HFD2_k127_2969847_17 Bacterial extracellular solute-binding protein K02020,K22003 - 5.3.3.7 0.0000000000000000000000000000000000000000000008991 176.0
HFD2_k127_2969847_18 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000001186 176.0
HFD2_k127_2969847_2 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 398.0
HFD2_k127_2969847_20 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000001626 154.0
HFD2_k127_2969847_21 FR47-like protein - - - 0.00000000000000000000000000000000000001858 149.0
HFD2_k127_2969847_22 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000001177 144.0
HFD2_k127_2969847_23 Tetratricopeptide repeat - - - 0.00000000000000000000000000000003284 145.0
HFD2_k127_2969847_24 Could be involved in septation K06412 - - 0.000000000000000000000000001222 120.0
HFD2_k127_2969847_25 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000007782 119.0
HFD2_k127_2969847_26 TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN K07003 - - 0.000000000000000000000004961 120.0
HFD2_k127_2969847_27 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000646 104.0
HFD2_k127_2969847_28 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000001396 91.0
HFD2_k127_2969847_29 Amb_all K01728 - 4.2.2.2 0.0000007627 63.0
HFD2_k127_2969847_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 396.0
HFD2_k127_2969847_30 - - - - 0.00000182 56.0
HFD2_k127_2969847_31 - - - - 0.0002141 51.0
HFD2_k127_2969847_4 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 355.0
HFD2_k127_2969847_5 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 331.0
HFD2_k127_2969847_6 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 324.0
HFD2_k127_2969847_7 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 295.0
HFD2_k127_2969847_8 cellulose binding K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003813 298.0
HFD2_k127_2969847_9 AraC family transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000001431 231.0
HFD2_k127_3032472_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 402.0
HFD2_k127_3032472_1 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000003576 149.0
HFD2_k127_3032472_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000001411 82.0
HFD2_k127_3059473_0 Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1386.0
HFD2_k127_3059473_1 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029,K02030 - - 2.167e-216 701.0
HFD2_k127_3059473_10 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000000000000000000000003862 222.0
HFD2_k127_3059473_11 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000000000000000000005554 211.0
HFD2_k127_3059473_12 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000006631 195.0
HFD2_k127_3059473_14 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.00000000000000000000000000000000000007782 158.0
HFD2_k127_3059473_15 YMGG-like Gly-zipper - - - 0.00000000000000000000000000000002882 135.0
HFD2_k127_3059473_16 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000007953 123.0
HFD2_k127_3059473_17 phosphorelay signal transduction system K14987 - - 0.0000000000000000000000000003838 119.0
HFD2_k127_3059473_18 - - - - 0.00000000000000000000000000145 120.0
HFD2_k127_3059473_19 Membrane - - - 0.00000000000000000000000008509 125.0
HFD2_k127_3059473_2 Penicillin amidase K01434 - 3.5.1.11 5.403e-209 713.0
HFD2_k127_3059473_20 transporter antisigma-factor antagonist STAS K04749 - - 0.000000000000000000000009157 109.0
HFD2_k127_3059473_21 Metallo-peptidase family M12B Reprolysin-like - - - 0.00000000000000000000009975 117.0
HFD2_k127_3059473_22 - - - - 0.0000000000000000000002082 106.0
HFD2_k127_3059473_23 Domain of unknown function (DUF4136) - - - 0.0000000000000007301 88.0
HFD2_k127_3059473_24 TonB-dependent receptor K02014 - - 0.00000000001688 68.0
HFD2_k127_3059473_26 guanyl-nucleotide exchange factor activity - - - 0.000000002046 70.0
HFD2_k127_3059473_27 Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - 0.000001692 56.0
HFD2_k127_3059473_3 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 609.0
HFD2_k127_3059473_4 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 514.0
HFD2_k127_3059473_5 COG0659 Sulfate permease and related transporters (MFS superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 483.0
HFD2_k127_3059473_6 Biotin-lipoyl like K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009825 357.0
HFD2_k127_3059473_7 PFAM lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 342.0
HFD2_k127_3059473_8 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001788 268.0
HFD2_k127_3059473_9 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000008788 224.0
HFD2_k127_3082148_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 1.85e-205 649.0
HFD2_k127_3082148_1 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 6.284e-199 644.0
HFD2_k127_3082148_10 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000005003 250.0
HFD2_k127_3082148_11 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000005903 210.0
HFD2_k127_3082148_12 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000003624 185.0
HFD2_k127_3082148_13 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000009982 169.0
HFD2_k127_3082148_14 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.0000000000000000000000000000000000000000371 161.0
HFD2_k127_3082148_15 domain, Protein - - - 0.000000000000000000000000000000000002198 160.0
HFD2_k127_3082148_16 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000003598 125.0
HFD2_k127_3082148_17 Membrane - - - 0.000000000000000000000000000008769 139.0
HFD2_k127_3082148_18 PASTA K12132 - 2.7.11.1 0.0000000000000000000005781 108.0
HFD2_k127_3082148_19 Outer membrane lipoprotein K05807,K08309 GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.0000000000000000000009239 107.0
HFD2_k127_3082148_2 Mur ligase middle domain K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 464.0
HFD2_k127_3082148_20 Glutathione peroxidase - - - 0.00000000000000002605 91.0
HFD2_k127_3082148_21 CAAX protease self-immunity K07052 - - 0.00000008266 63.0
HFD2_k127_3082148_22 protein involved in outer membrane biogenesis K07289 - - 0.0000004962 63.0
HFD2_k127_3082148_3 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 416.0
HFD2_k127_3082148_4 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 346.0
HFD2_k127_3082148_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000006138 268.0
HFD2_k127_3082148_6 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001766 262.0
HFD2_k127_3082148_7 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000002461 258.0
HFD2_k127_3082148_8 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000001473 245.0
HFD2_k127_3082148_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000002387 246.0
HFD2_k127_3113923_0 PFAM aminotransferase, class I K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005933 507.0
HFD2_k127_3113923_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000046 271.0
HFD2_k127_3113923_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000006233 253.0
HFD2_k127_3113923_3 methyltransferase activity K13307,K13330 - 2.1.1.235,2.1.1.324 0.00000000000000004143 90.0
HFD2_k127_3165813_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1138.0
HFD2_k127_3165813_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1083.0
HFD2_k127_3165813_10 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 575.0
HFD2_k127_3165813_100 Gram-negative bacterial TonB protein C-terminal - - - 0.00000002173 66.0
HFD2_k127_3165813_101 pathogenesis - - - 0.0000006613 63.0
HFD2_k127_3165813_102 PEP-CTERM system TPR-repeat lipoprotein - - - 0.000001546 62.0
HFD2_k127_3165813_103 COG0457 FOG TPR repeat - - - 0.0001209 55.0
HFD2_k127_3165813_104 SMART ATP-binding region ATPase domain protein - - - 0.0001627 53.0
HFD2_k127_3165813_105 Cupin domain - - - 0.0002915 50.0
HFD2_k127_3165813_106 TonB-dependent Receptor Plug Domain - - - 0.0002999 44.0
HFD2_k127_3165813_11 ABC1 family K03688 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 552.0
HFD2_k127_3165813_12 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 537.0
HFD2_k127_3165813_13 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 527.0
HFD2_k127_3165813_14 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 484.0
HFD2_k127_3165813_15 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 470.0
HFD2_k127_3165813_16 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 451.0
HFD2_k127_3165813_17 ABC transporter substrate-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 466.0
HFD2_k127_3165813_18 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 436.0
HFD2_k127_3165813_19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 439.0
HFD2_k127_3165813_2 coagulation factor 5 8 type - - - 1.289e-282 913.0
HFD2_k127_3165813_20 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 409.0
HFD2_k127_3165813_21 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 409.0
HFD2_k127_3165813_22 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 405.0
HFD2_k127_3165813_23 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 407.0
HFD2_k127_3165813_24 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 400.0
HFD2_k127_3165813_25 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 374.0
HFD2_k127_3165813_26 ABC-type sugar transport systems, permease components K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 384.0
HFD2_k127_3165813_27 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 361.0
HFD2_k127_3165813_28 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 366.0
HFD2_k127_3165813_29 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 353.0
HFD2_k127_3165813_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168,K07479 GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 4.878e-262 833.0
HFD2_k127_3165813_30 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 332.0
HFD2_k127_3165813_31 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 326.0
HFD2_k127_3165813_32 LacI family K02529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 355.0
HFD2_k127_3165813_33 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 343.0
HFD2_k127_3165813_34 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 334.0
HFD2_k127_3165813_35 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 340.0
HFD2_k127_3165813_36 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 299.0
HFD2_k127_3165813_37 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 307.0
HFD2_k127_3165813_38 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000001697 288.0
HFD2_k127_3165813_39 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004492 267.0
HFD2_k127_3165813_4 PFAM RNA polymerase sigma factor 54, interaction - - - 4.538e-236 749.0
HFD2_k127_3165813_40 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001324 266.0
HFD2_k127_3165813_41 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000008554 267.0
HFD2_k127_3165813_42 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000006241 262.0
HFD2_k127_3165813_43 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000004253 226.0
HFD2_k127_3165813_44 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000004038 236.0
HFD2_k127_3165813_45 Penicillin binding protein transpeptidase domain K17838 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000002327 222.0
HFD2_k127_3165813_46 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000004402 231.0
HFD2_k127_3165813_47 PFAM ABC transporter related K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000004778 222.0
HFD2_k127_3165813_48 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000001286 203.0
HFD2_k127_3165813_49 AAA domain - - - 0.000000000000000000000000000000000000000000000000004061 204.0
HFD2_k127_3165813_5 Outer membrane receptor - - - 2.307e-229 744.0
HFD2_k127_3165813_50 spore germination K07790 - - 0.00000000000000000000000000000000000000000000000003112 201.0
HFD2_k127_3165813_51 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000000009303 192.0
HFD2_k127_3165813_52 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000001228 189.0
HFD2_k127_3165813_53 cyclic nucleotide binding K10914 - - 0.00000000000000000000000000000000000000000000001991 186.0
HFD2_k127_3165813_54 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000009639 180.0
HFD2_k127_3165813_55 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000006246 182.0
HFD2_k127_3165813_56 Peptidase family M48 - - - 0.000000000000000000000000000000000000000001143 172.0
HFD2_k127_3165813_57 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000003987 168.0
HFD2_k127_3165813_58 Cation efflux family - - - 0.00000000000000000000000000000000000000001381 165.0
HFD2_k127_3165813_59 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000002861 175.0
HFD2_k127_3165813_6 glycosyltransferase 36 associated - - - 2.627e-218 709.0
HFD2_k127_3165813_60 AI-2E family transporter - - - 0.00000000000000000000000000000000000000009086 164.0
HFD2_k127_3165813_61 creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000004805 158.0
HFD2_k127_3165813_62 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000007182 165.0
HFD2_k127_3165813_63 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000009615 153.0
HFD2_k127_3165813_64 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000101 163.0
HFD2_k127_3165813_65 - - - - 0.0000000000000000000000000000000000002057 149.0
HFD2_k127_3165813_66 Protein of unknown function, DUF547 - - - 0.0000000000000000000000000000000000005309 162.0
HFD2_k127_3165813_67 Nucleotidyl transferase K00966,K16881 - 2.7.7.13,5.4.2.8 0.000000000000000000000000000000000001422 154.0
HFD2_k127_3165813_68 Outer membrane receptor proteins mostly Fe transport K02014 - - 0.0000000000000000000000000000000000283 155.0
HFD2_k127_3165813_69 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000001259 141.0
HFD2_k127_3165813_7 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 602.0
HFD2_k127_3165813_70 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000002816 149.0
HFD2_k127_3165813_71 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.000000000000000000000000000000005495 137.0
HFD2_k127_3165813_72 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000000015 138.0
HFD2_k127_3165813_73 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000001011 133.0
HFD2_k127_3165813_74 NTPase K06928 - 3.6.1.15 0.0000000000000000000000000000001041 137.0
HFD2_k127_3165813_75 Protein of unknown function, DUF393 - - - 0.0000000000000000000000000000002799 129.0
HFD2_k127_3165813_76 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.00000000000000000000000000002185 123.0
HFD2_k127_3165813_77 RNA recognition motif - - - 0.00000000000000000000000000008012 118.0
HFD2_k127_3165813_78 CYTH K05873 - 4.6.1.1 0.0000000000000000000000000003056 134.0
HFD2_k127_3165813_79 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000006985 116.0
HFD2_k127_3165813_8 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 601.0
HFD2_k127_3165813_80 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000088 118.0
HFD2_k127_3165813_81 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000006453 124.0
HFD2_k127_3165813_82 HEAT repeat - - - 0.00000000000000000000007856 113.0
HFD2_k127_3165813_83 Hydrogenase maturation protease - - - 0.00000000000000000000007911 114.0
HFD2_k127_3165813_84 glycosyl transferase family 39 - - - 0.0000000000000000000001567 115.0
HFD2_k127_3165813_85 PHB/PHA accumulation regulator DNA-binding domain - - - 0.00000000000000000001616 97.0
HFD2_k127_3165813_86 PFAM nuclease (SNase domain protein) K01174 - 3.1.31.1 0.00000000000000000004804 98.0
HFD2_k127_3165813_87 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000001262 102.0
HFD2_k127_3165813_88 Sulfurtransferase - - - 0.000000000000004123 78.0
HFD2_k127_3165813_89 TIGRFAM TonB family protein K03832 - - 0.00000000000009718 77.0
HFD2_k127_3165813_9 DNA photolyase K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 591.0
HFD2_k127_3165813_90 - - - - 0.0000000000005585 79.0
HFD2_k127_3165813_91 toxin-antitoxin pair type II binding - - - 0.000000000004838 70.0
HFD2_k127_3165813_92 Mycolic acid cyclopropane synthetase K00568 - 2.1.1.222,2.1.1.64 0.000000000006312 75.0
HFD2_k127_3165813_93 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000006823 71.0
HFD2_k127_3165813_94 - - - - 0.000000000009046 70.0
HFD2_k127_3165813_95 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000009134 73.0
HFD2_k127_3165813_96 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000009958 71.0
HFD2_k127_3165813_97 Putative zinc-finger - - - 0.000000001061 64.0
HFD2_k127_3165813_98 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000001437 71.0
HFD2_k127_3165813_99 Uncharacterised protein family (UPF0158) - - - 0.000000002956 64.0
HFD2_k127_3234292_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.306e-242 760.0
HFD2_k127_3234292_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 357.0
HFD2_k127_3234292_2 PFAM Peptidase M20 K01436,K12940 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 360.0
HFD2_k127_3234292_3 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 306.0
HFD2_k127_3234292_4 PFAM glycine cleavage T protein (aminomethyl transferase) K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000911 174.0
HFD2_k127_3234292_5 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000007355 170.0
HFD2_k127_3234292_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000000672 138.0
HFD2_k127_3234292_7 EamA-like transporter family - - - 0.0000000000000000000004606 108.0
HFD2_k127_3234292_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000005642 63.0
HFD2_k127_3251774_0 Belongs to the aldehyde dehydrogenase family K00128,K00130,K10217 - 1.2.1.3,1.2.1.32,1.2.1.8,1.2.1.85 9.645e-201 649.0
HFD2_k127_3251774_1 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003284 295.0
HFD2_k127_3251774_2 Zn peptidase - - - 0.000000000000000000000000000000000276 147.0
HFD2_k127_3251774_3 PFAM methyltransferase small - - - 0.0003805 51.0
HFD2_k127_3253069_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667 - 4.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 603.0
HFD2_k127_3253069_1 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 479.0
HFD2_k127_3253069_2 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000001385 277.0
HFD2_k127_3253069_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000329 180.0
HFD2_k127_3253069_4 Phospholipid methyltransferase - - - 0.00000000000000000004169 106.0
HFD2_k127_3253069_5 serine threonine protein kinase - - - 0.00000000000000006372 91.0
HFD2_k127_3253069_6 serine threonine protein kinase - - - 0.0001318 53.0
HFD2_k127_3406367_0 Gram-negative bacterial TonB protein C-terminal - - - 0.00000001622 65.0
HFD2_k127_3406367_1 TIGRFAM TonB family protein K03832 - - 0.0000000679 65.0
HFD2_k127_3421674_0 methyltransferase - - - 0.0000000000000000000000000009414 123.0
HFD2_k127_3421674_3 Putative metal-binding motif - - - 0.000002132 59.0
HFD2_k127_3421674_4 Hemolysin-type calcium-binding repeat 2 copies family protein - - - 0.0004317 54.0
HFD2_k127_3526702_0 Sodium Bile acid symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004821 496.0
HFD2_k127_3526702_1 Pkd domain containing protein K12567 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 429.0
HFD2_k127_3526702_10 regulatory protein, arsR K03892,K21903 - - 0.000000000000000000000004404 105.0
HFD2_k127_3526702_11 Amidohydrolase family - - - 0.00000000000000000000004254 110.0
HFD2_k127_3526702_12 regulatory protein, arsR K03892,K21903 - - 0.000000000000000000003323 100.0
HFD2_k127_3526702_13 DGC domain - - - 0.00000000000000000001015 102.0
HFD2_k127_3526702_14 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000009413 79.0
HFD2_k127_3526702_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000001516 88.0
HFD2_k127_3526702_16 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.0000000006382 71.0
HFD2_k127_3526702_17 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K05970 - 3.1.1.53 0.000000003561 71.0
HFD2_k127_3526702_18 amine dehydrogenase activity - - - 0.0000009242 63.0
HFD2_k127_3526702_19 Carboxypeptidase - - - 0.00001383 59.0
HFD2_k127_3526702_2 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003149 273.0
HFD2_k127_3526702_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000005377 244.0
HFD2_k127_3526702_4 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000003974 219.0
HFD2_k127_3526702_5 DGC domain - - - 0.00000000000000000000000000000000006572 143.0
HFD2_k127_3526702_6 OsmC-like protein - - - 0.00000000000000000000000000001003 128.0
HFD2_k127_3526702_7 Pfam Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000003815 128.0
HFD2_k127_3526702_8 DGC domain K02437 - - 0.00000000000000000000000007768 112.0
HFD2_k127_3526702_9 Thioredoxin domain - - - 0.000000000000000000000004033 103.0
HFD2_k127_3533223_0 Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009935 509.0
HFD2_k127_3533223_1 lipolytic protein G-D-S-L family K05970 - 3.1.1.53 0.00000000000000000000000000000006115 145.0
HFD2_k127_3533223_2 Outer membrane receptor K02014,K16087 - - 0.000000000000000000000000000002463 140.0
HFD2_k127_3533223_3 Outer membrane receptor proteins mostly Fe transport K02014 - - 0.00000000000000000007506 105.0
HFD2_k127_3613922_0 Glutamine synthetase type III K01915 - 6.3.1.2 3.005e-298 930.0
HFD2_k127_3613922_1 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 1.367e-205 647.0
HFD2_k127_3613922_12 Sterol carrier protein - - - 0.000009092 59.0
HFD2_k127_3613922_2 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 607.0
HFD2_k127_3613922_3 sigma factor activity K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 451.0
HFD2_k127_3613922_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 361.0
HFD2_k127_3613922_5 FAD binding domain K00103,K00279 - 1.1.3.8,1.5.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 309.0
HFD2_k127_3613922_6 YCII-related domain - - - 0.000000000000000000000000000000000000000009191 157.0
HFD2_k127_3613922_7 Highly conserved protein containing a thioredoxin domain - - - 0.0000000000000000000000000000000000000001569 163.0
HFD2_k127_3613922_9 Thrombospondin type 3 repeat - - - 0.000000000000000000000009121 117.0
HFD2_k127_3626731_0 Sortilin, neurotensin receptor 3, - - - 0.0 1065.0
HFD2_k127_3626731_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 7.565e-215 698.0
HFD2_k127_3626731_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 287.0
HFD2_k127_3626731_3 YHS domain protein - - - 0.0000000000000000000000000000000005435 137.0
HFD2_k127_3626731_4 PFAM Na-Ca exchanger integrin-beta4 - - - 0.0000000000000000000000001232 113.0
HFD2_k127_3626733_0 Glycosyltransferase Family 4 - - - 0.0 1242.0
HFD2_k127_3626733_1 cysteine protease - - - 4.552e-238 751.0
HFD2_k127_3626733_10 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 299.0
HFD2_k127_3626733_11 arylsulfatase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 310.0
HFD2_k127_3626733_12 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009195 285.0
HFD2_k127_3626733_13 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009396 292.0
HFD2_k127_3626733_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001363 236.0
HFD2_k127_3626733_15 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000001434 252.0
HFD2_k127_3626733_16 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000005709 203.0
HFD2_k127_3626733_17 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000008612 183.0
HFD2_k127_3626733_18 - - - - 0.00000000000000000000000000000000000000008565 163.0
HFD2_k127_3626733_19 of the cupin superfamily K06995 - - 0.0000000000000000000000000000000000000004475 150.0
HFD2_k127_3626733_2 oligopeptide transport K03305 - - 4.681e-208 659.0
HFD2_k127_3626733_20 Tyrosine phosphatase family - - - 0.00000000000000000000000000000005738 134.0
HFD2_k127_3626733_21 DNA-templated transcription, initiation - - - 0.000000000000000000000000000004404 136.0
HFD2_k127_3626733_22 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000002628 135.0
HFD2_k127_3626733_24 Domain of unknown function (DUF4956) - - - 0.000000001723 70.0
HFD2_k127_3626733_25 - - - - 0.00001287 58.0
HFD2_k127_3626733_3 beta-1,4-mannooligosaccharide phosphorylase - - - 4.197e-195 627.0
HFD2_k127_3626733_4 Glycosyl hydrolases family 43 K06113 - 3.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 601.0
HFD2_k127_3626733_5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 484.0
HFD2_k127_3626733_6 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 473.0
HFD2_k127_3626733_7 SMART Tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 404.0
HFD2_k127_3626733_8 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 317.0
HFD2_k127_3626733_9 arylsulfatase A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 329.0
HFD2_k127_3687598_0 Prolyl oligopeptidase family - - - 4.438e-305 949.0
HFD2_k127_3687598_1 xanthine dehydrogenase activity K04108 - 1.3.7.9 2.357e-267 865.0
HFD2_k127_3687598_10 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 457.0
HFD2_k127_3687598_11 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 451.0
HFD2_k127_3687598_12 Domain of unknown function (DUF4301) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 449.0
HFD2_k127_3687598_13 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 394.0
HFD2_k127_3687598_14 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 378.0
HFD2_k127_3687598_15 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 383.0
HFD2_k127_3687598_16 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 372.0
HFD2_k127_3687598_17 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 340.0
HFD2_k127_3687598_18 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 331.0
HFD2_k127_3687598_19 UvrD REP helicase K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 352.0
HFD2_k127_3687598_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 3.325e-236 765.0
HFD2_k127_3687598_20 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 324.0
HFD2_k127_3687598_21 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 313.0
HFD2_k127_3687598_22 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 311.0
HFD2_k127_3687598_23 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 310.0
HFD2_k127_3687598_24 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 300.0
HFD2_k127_3687598_25 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001395 265.0
HFD2_k127_3687598_26 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002454 262.0
HFD2_k127_3687598_27 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000512 250.0
HFD2_k127_3687598_28 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000008121 207.0
HFD2_k127_3687598_29 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000001061 218.0
HFD2_k127_3687598_3 Glycogen debranching enzyme - - - 6.082e-224 719.0
HFD2_k127_3687598_30 esterase - - - 0.00000000000000000000000000000000000000000000000000000001096 222.0
HFD2_k127_3687598_31 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000003819 196.0
HFD2_k127_3687598_32 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000009825 191.0
HFD2_k127_3687598_33 positive regulation of proteasomal protein catabolic process - - - 0.0000000000000000000000000000000000000000000007517 186.0
HFD2_k127_3687598_34 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.00000000000000000000000000000000000000003404 167.0
HFD2_k127_3687598_35 peptidyl-prolyl cis-trans isomerase activity K03769,K03771 - 5.2.1.8 0.0000000000000000000000000000000000000001084 169.0
HFD2_k127_3687598_36 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000000005305 165.0
HFD2_k127_3687598_37 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000001271 165.0
HFD2_k127_3687598_38 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.0000000000000000000000000000000000226 153.0
HFD2_k127_3687598_39 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000006252 138.0
HFD2_k127_3687598_4 5TM C-terminal transporter carbon starvation CstA K06200 - - 4.465e-198 636.0
HFD2_k127_3687598_40 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.000000000000000000000000000002951 134.0
HFD2_k127_3687598_41 Smr domain - - - 0.0000000000000000000000000003249 116.0
HFD2_k127_3687598_42 exonuclease activity K16899 - 3.6.4.12 0.000000000000000000000000006584 129.0
HFD2_k127_3687598_43 Belongs to the ArsC family - - - 0.0000000000000000000000008436 106.0
HFD2_k127_3687598_44 glycosyl transferase family K07151 - 2.4.99.18 0.00000000000000000000000131 119.0
HFD2_k127_3687598_45 Peptidase family M1 domain - - - 0.000000000000000000001067 109.0
HFD2_k127_3687598_46 IMP dehydrogenase activity - - - 0.000000000000000000002606 98.0
HFD2_k127_3687598_48 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000002347 91.0
HFD2_k127_3687598_49 Protein of unknown function (DUF1571) - - - 0.0000000000000001721 91.0
HFD2_k127_3687598_5 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 522.0
HFD2_k127_3687598_50 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000119 81.0
HFD2_k127_3687598_51 Contains selenocysteine K07401 - - 0.0000000000006958 70.0
HFD2_k127_3687598_52 Predicted membrane protein (DUF2231) - - - 0.000000002258 64.0
HFD2_k127_3687598_53 peptidyl-tyrosine sulfation - - - 0.00000002905 65.0
HFD2_k127_3687598_54 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000008567 58.0
HFD2_k127_3687598_55 Aspartyl protease - - - 0.0000001281 64.0
HFD2_k127_3687598_56 - - - - 0.000008954 52.0
HFD2_k127_3687598_57 YCII-related domain K09780 - - 0.0000192 56.0
HFD2_k127_3687598_58 von Willebrand factor type A domain - - - 0.00004334 57.0
HFD2_k127_3687598_59 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0001802 53.0
HFD2_k127_3687598_6 Mismatch repair ATPase (MutS family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 533.0
HFD2_k127_3687598_7 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 486.0
HFD2_k127_3687598_8 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 485.0
HFD2_k127_3687598_9 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 465.0
HFD2_k127_3712716_0 PKD domain - - - 0.000000000000007018 85.0
HFD2_k127_3712716_1 Calcium ion binding. It is involved in the biological process described with cell adhesion K04659 GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002020,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0008289,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010941,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0019842,GO:0019899,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030198,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0036094,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043394,GO:0043395,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048736,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060173,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0060548,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097159,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181 - 0.000009597 57.0
HFD2_k127_3772650_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004573 302.0
HFD2_k127_3772650_1 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006272 251.0
HFD2_k127_3772650_2 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000002787 189.0
HFD2_k127_3772650_3 Acyltransferase family - - - 0.000000000000000000000000000000000000000006207 172.0
HFD2_k127_3831961_0 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008495 250.0
HFD2_k127_3831961_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000006103 159.0
HFD2_k127_3831961_2 Transcriptional regulator K07734 - - 0.00000000000001117 76.0
HFD2_k127_3894523_0 PFAM RNA binding S1 domain protein K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 354.0
HFD2_k127_3894523_1 Domain of unknown function (DUF4412) - - - 0.0000000000007145 78.0
HFD2_k127_3894523_2 - - - - 0.0000001198 62.0
HFD2_k127_3894523_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03169 - 5.99.1.2 0.00009597 53.0
HFD2_k127_3897779_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.649e-228 719.0
HFD2_k127_3897779_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 515.0
HFD2_k127_3897779_10 Ribonuclease HII K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000133 218.0
HFD2_k127_3897779_11 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000007069 205.0
HFD2_k127_3897779_12 adenosine deaminase K01488,K02029,K21053 - 3.5.4.2,3.5.4.4 0.00000000000000000000000000000000000000000000000000002198 216.0
HFD2_k127_3897779_13 FAD binding domain K21401 - 1.3.99.38 0.0000000000000000000000000000000000000000000000000008845 202.0
HFD2_k127_3897779_14 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000004341 150.0
HFD2_k127_3897779_15 Methyltransferase domain - - - 0.00000000000000000000000000000000001457 145.0
HFD2_k127_3897779_16 cheY-homologous receiver domain - - - 0.000000000000000000000000000145 134.0
HFD2_k127_3897779_17 Domain of unknown function (DUF309) K09763 - - 0.0000000000000001073 85.0
HFD2_k127_3897779_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 484.0
HFD2_k127_3897779_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 466.0
HFD2_k127_3897779_4 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 405.0
HFD2_k127_3897779_5 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 406.0
HFD2_k127_3897779_6 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 404.0
HFD2_k127_3897779_7 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 401.0
HFD2_k127_3897779_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 398.0
HFD2_k127_3897779_9 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001192 280.0
HFD2_k127_4048653_0 PFAM polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 464.0
HFD2_k127_4048653_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 400.0
HFD2_k127_4048653_10 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000002584 163.0
HFD2_k127_4048653_11 protein involved in exopolysaccharide biosynthesis - - - 0.000000000000000000000000000000000000000008052 177.0
HFD2_k127_4048653_12 AAA domain K08252 - 2.7.10.1 0.0000000000000000000000000000000000000007145 159.0
HFD2_k127_4048653_13 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000789 155.0
HFD2_k127_4048653_14 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000008272 149.0
HFD2_k127_4048653_15 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000007169 150.0
HFD2_k127_4048653_16 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000001029 138.0
HFD2_k127_4048653_17 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.000000000000000000000000000002503 126.0
HFD2_k127_4048653_18 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000006704 110.0
HFD2_k127_4048653_19 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000006161 116.0
HFD2_k127_4048653_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 372.0
HFD2_k127_4048653_20 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000006796 101.0
HFD2_k127_4048653_21 Phosphoribosyl transferase domain - - - 0.000000000000000004407 94.0
HFD2_k127_4048653_22 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000001559 92.0
HFD2_k127_4048653_23 Resolvase, N terminal domain - - - 0.00000001079 65.0
HFD2_k127_4048653_26 HPr kinase - - - 0.0008306 51.0
HFD2_k127_4048653_3 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 300.0
HFD2_k127_4048653_4 response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001969 281.0
HFD2_k127_4048653_5 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001232 253.0
HFD2_k127_4048653_6 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000000000000007543 241.0
HFD2_k127_4048653_7 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000006276 228.0
HFD2_k127_4048653_8 lipopolysaccharide metabolic process K19804 - - 0.0000000000000000000000000000000000000000000000000000001631 212.0
HFD2_k127_4048653_9 PFAM Roadblock LC7 family protein - - - 0.00000000000000000000000000000000000000000000000000008089 191.0
HFD2_k127_4082434_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.0 1136.0
HFD2_k127_4082434_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 7.667e-207 661.0
HFD2_k127_4082434_10 pfkB family carbohydrate kinase K00852,K00856 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 346.0
HFD2_k127_4082434_11 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 325.0
HFD2_k127_4082434_12 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 316.0
HFD2_k127_4082434_13 Permease, YjgP YjgQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006045 328.0
HFD2_k127_4082434_14 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007654 277.0
HFD2_k127_4082434_15 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003099 276.0
HFD2_k127_4082434_16 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000001712 271.0
HFD2_k127_4082434_17 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000002838 274.0
HFD2_k127_4082434_18 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000001822 248.0
HFD2_k127_4082434_19 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000001188 207.0
HFD2_k127_4082434_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 4.807e-199 649.0
HFD2_k127_4082434_20 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000003744 189.0
HFD2_k127_4082434_21 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000006733 188.0
HFD2_k127_4082434_22 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000002527 189.0
HFD2_k127_4082434_23 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000001729 183.0
HFD2_k127_4082434_24 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000006507 181.0
HFD2_k127_4082434_25 histone H2A K63-linked ubiquitination K10914 - - 0.00000000000000000000000000000000000000009166 160.0
HFD2_k127_4082434_26 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.0000000000000000000000000000000000009785 157.0
HFD2_k127_4082434_27 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000002662 148.0
HFD2_k127_4082434_28 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000003172 147.0
HFD2_k127_4082434_29 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000015 138.0
HFD2_k127_4082434_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 616.0
HFD2_k127_4082434_30 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000002099 133.0
HFD2_k127_4082434_31 Oxygen tolerance - - - 0.0000000000000000000000003338 114.0
HFD2_k127_4082434_32 Lipopolysaccharide-assembly - - - 0.0000000000000000000182 103.0
HFD2_k127_4082434_33 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.00000000002768 76.0
HFD2_k127_4082434_34 ribonuclease BN K07058 - - 0.00000000005104 74.0
HFD2_k127_4082434_4 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 555.0
HFD2_k127_4082434_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 509.0
HFD2_k127_4082434_6 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 418.0
HFD2_k127_4082434_7 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 392.0
HFD2_k127_4082434_8 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 375.0
HFD2_k127_4082434_9 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 368.0
HFD2_k127_4104713_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.026e-233 741.0
HFD2_k127_4104713_1 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 6.671e-214 674.0
HFD2_k127_4104713_10 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 325.0
HFD2_k127_4104713_11 Protein export membrane protein K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002282 289.0
HFD2_k127_4104713_12 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000008466 255.0
HFD2_k127_4104713_13 Secondary thiamine-phosphate synthase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007865 244.0
HFD2_k127_4104713_14 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000001207 253.0
HFD2_k127_4104713_15 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001999 231.0
HFD2_k127_4104713_16 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000003376 218.0
HFD2_k127_4104713_17 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000008627 216.0
HFD2_k127_4104713_18 Glucose-6-phosphate dehydrogenase subunit - - - 0.000000000000000000000000000000000000001401 161.0
HFD2_k127_4104713_19 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000000000003878 130.0
HFD2_k127_4104713_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.201e-198 632.0
HFD2_k127_4104713_20 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000004534 142.0
HFD2_k127_4104713_21 Reverse transcriptase-like K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.000000000000000000000000000007921 133.0
HFD2_k127_4104713_22 RNA recognition motif - - - 0.0000000000000000000000000001039 122.0
HFD2_k127_4104713_23 Septum formation initiator K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000001755 86.0
HFD2_k127_4104713_25 C4-type zinc ribbon domain K07164 - - 0.0000000000002168 79.0
HFD2_k127_4104713_26 Cytidylyltransferase family K00981 - 2.7.7.41 0.00001279 58.0
HFD2_k127_4104713_27 Bacterial membrane protein YfhO - - - 0.0000151 58.0
HFD2_k127_4104713_3 Dehydrogenase E1 component K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004919 608.0
HFD2_k127_4104713_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 563.0
HFD2_k127_4104713_5 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 555.0
HFD2_k127_4104713_6 Aldo/keto reductase family K05882 - 1.1.1.91 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 421.0
HFD2_k127_4104713_7 membrane protein required for spore maturation in B.subtilis K06374 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 400.0
HFD2_k127_4104713_8 TIGRFAM 6-phosphogluconate dehydrogenase, decarboxylating K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 411.0
HFD2_k127_4104713_9 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 369.0
HFD2_k127_4118085_0 Predicted membrane protein (DUF2339) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000702 267.0
HFD2_k127_4118085_1 membrane - - - 0.0000005414 64.0
HFD2_k127_4233333_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 390.0
HFD2_k127_4233333_1 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000001181 187.0
HFD2_k127_4233333_2 Belongs to the glycosyl hydrolase 43 family K20276 - - 0.0000000008484 73.0
HFD2_k127_4371219_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1257.0
HFD2_k127_4371219_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.65e-270 857.0
HFD2_k127_4371219_10 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000127 281.0
HFD2_k127_4371219_11 to Saccharomyces cerevisiae LYS9 (YNR050C) K00293,K00797 GO:0003674,GO:0003824,GO:0004753,GO:0004755,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.10,2.5.1.16 0.00000000000000007318 83.0
HFD2_k127_4371219_13 NfeD-like C-terminal, partner-binding K07403 - - 0.000006057 57.0
HFD2_k127_4371219_2 copper-translocating P-type ATPase K17686 - 3.6.3.54 2.644e-250 792.0
HFD2_k127_4371219_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 455.0
HFD2_k127_4371219_4 Branched-chain amino acid transport system / permease component K01997,K11960 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 360.0
HFD2_k127_4371219_5 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 377.0
HFD2_k127_4371219_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 334.0
HFD2_k127_4371219_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 323.0
HFD2_k127_4371219_8 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 303.0
HFD2_k127_4371219_9 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 286.0
HFD2_k127_447055_0 Luciferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006708 276.0
HFD2_k127_447055_1 AMP-binding enzyme K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005001 287.0
HFD2_k127_447055_2 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000006744 246.0
HFD2_k127_447055_3 Acyl-CoA dehydrogenase, C-terminal domain K00253,K21782 GO:0003674,GO:0003824,GO:0003995,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249,GO:0055114 1.3.8.14,1.3.8.4 0.0000000000000000000000000000000000002248 156.0
HFD2_k127_447055_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000001567 143.0
HFD2_k127_447055_5 Acyl-transferase K00655 - 2.3.1.51 0.000000000000000000000000008724 126.0
HFD2_k127_447055_6 acyltransferase K00655 - 2.3.1.51 0.000000000000004003 86.0
HFD2_k127_447055_7 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00002021 52.0
HFD2_k127_447055_8 Non-ribosomal peptide synthetase modules and related proteins - - - 0.00009548 55.0
HFD2_k127_4479631_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K10535 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 592.0
HFD2_k127_4479631_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 556.0
HFD2_k127_4479631_2 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 370.0
HFD2_k127_4479631_3 TGS domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008249 278.0
HFD2_k127_4479631_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000001538 219.0
HFD2_k127_4479631_5 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000004802 196.0
HFD2_k127_4479631_6 - - - - 0.0000000000000000000000000000000001039 143.0
HFD2_k127_4479631_8 nitrate reductase, gamma subunit K00374 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 1.7.5.1 0.0000008322 52.0
HFD2_k127_4479631_9 glutamate synthase (NADPH) K00266 - 1.4.1.13,1.4.1.14 0.00001077 47.0
HFD2_k127_4493265_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 490.0
HFD2_k127_4493265_1 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 456.0
HFD2_k127_4493265_10 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001589 299.0
HFD2_k127_4493265_11 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000004625 243.0
HFD2_k127_4493265_12 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000009776 207.0
HFD2_k127_4493265_13 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000007484 204.0
HFD2_k127_4493265_14 Glycosyltransferase like family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000008236 220.0
HFD2_k127_4493265_15 - - - - 0.0000000000000000000000000000000000000000000000000000002599 214.0
HFD2_k127_4493265_16 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000001984 217.0
HFD2_k127_4493265_17 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000000009831 194.0
HFD2_k127_4493265_18 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000001445 208.0
HFD2_k127_4493265_19 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000008353 182.0
HFD2_k127_4493265_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 464.0
HFD2_k127_4493265_20 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000223 166.0
HFD2_k127_4493265_21 Histidine kinase K02668,K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000005452 181.0
HFD2_k127_4493265_22 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000006851 174.0
HFD2_k127_4493265_23 glycosyl transferase group 1 - - - 0.000000000000000000000004886 119.0
HFD2_k127_4493265_24 Glycosyltransferase like family 2 - - - 0.00000000000000000000001185 112.0
HFD2_k127_4493265_25 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000004089 80.0
HFD2_k127_4493265_26 glucose sorbosone - - - 0.0000000000009941 83.0
HFD2_k127_4493265_29 protein transport across the cell outer membrane K02246,K08084 - - 0.00002173 54.0
HFD2_k127_4493265_3 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 415.0
HFD2_k127_4493265_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 321.0
HFD2_k127_4493265_5 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 325.0
HFD2_k127_4493265_6 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 305.0
HFD2_k127_4493265_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 328.0
HFD2_k127_4493265_8 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 315.0
HFD2_k127_4493265_9 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 296.0
HFD2_k127_4493444_0 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 544.0
HFD2_k127_4493444_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 464.0
HFD2_k127_4493444_10 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000002162 124.0
HFD2_k127_4493444_11 cyclic nucleotide binding K07058,K14266 - 1.14.19.9 0.0000000000000000000000000000008305 128.0
HFD2_k127_4493444_12 EamA-like transporter family - - - 0.00000000000000000000000002005 120.0
HFD2_k127_4493444_13 Cytochrome c554 and c-prime - - - 0.00000000000000000000000003622 128.0
HFD2_k127_4493444_14 Polymer-forming cytoskeletal - - - 0.00000000000000000000000004281 113.0
HFD2_k127_4493444_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000004754 118.0
HFD2_k127_4493444_16 - - - - 0.000000000002172 79.0
HFD2_k127_4493444_17 - - - - 0.0000000001491 74.0
HFD2_k127_4493444_18 - - - - 0.000000000789 72.0
HFD2_k127_4493444_19 TIGRFAM YD repeat protein - - - 0.000000003884 65.0
HFD2_k127_4493444_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 421.0
HFD2_k127_4493444_21 ADAM metallopeptidase domain 33 K06834,K06835,K06836,K08608,K08616 GO:0001817,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009889,GO:0010556,GO:0016020,GO:0016021,GO:0016787,GO:0019222,GO:0019538,GO:0031224,GO:0031323,GO:0031326,GO:0042035,GO:0042127,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051239,GO:0051246,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564 - 0.00007976 50.0
HFD2_k127_4493444_22 SnoaL-like domain - - - 0.00008423 52.0
HFD2_k127_4493444_23 - - - - 0.0003037 48.0
HFD2_k127_4493444_3 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 397.0
HFD2_k127_4493444_4 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 376.0
HFD2_k127_4493444_5 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004135 274.0
HFD2_k127_4493444_6 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
HFD2_k127_4493444_7 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000009053 212.0
HFD2_k127_4493444_8 negative regulation of transforming growth factor beta1 production K03068,K06261,K06593,K08867,K09187,K12488,K13738,K14972,K20050,K20371 GO:0000003,GO:0001654,GO:0001667,GO:0001745,GO:0002064,GO:0002065,GO:0002066,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005938,GO:0006928,GO:0006996,GO:0007010,GO:0007015,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007298,GO:0007423,GO:0008150,GO:0009653,GO:0009887,GO:0009888,GO:0009987,GO:0010564,GO:0010631,GO:0016020,GO:0016043,GO:0016477,GO:0017124,GO:0019904,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0030029,GO:0030036,GO:0030100,GO:0030154,GO:0030496,GO:0030707,GO:0030855,GO:0032153,GO:0032154,GO:0032155,GO:0032465,GO:0032501,GO:0032502,GO:0032504,GO:0032794,GO:0032879,GO:0034329,GO:0034330,GO:0034332,GO:0034333,GO:0040011,GO:0043062,GO:0043063,GO:0044085,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044448,GO:0044459,GO:0044464,GO:0044703,GO:0045171,GO:0045177,GO:0045179,GO:0045216,GO:0045807,GO:0048259,GO:0048260,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048592,GO:0048609,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050794,GO:0050839,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0051179,GO:0051302,GO:0051674,GO:0051704,GO:0051726,GO:0060429,GO:0060627,GO:0065007,GO:0071840,GO:0071944,GO:0090130,GO:0090132,GO:0090596,GO:0097435,GO:0098590,GO:0099568,GO:0099738 2.1.1.43,2.7.11.1 0.0000000000000000000000000000000000000000000000987 196.0
HFD2_k127_4493444_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000001041 144.0
HFD2_k127_4497580_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 565.0
HFD2_k127_4497580_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008998 395.0
HFD2_k127_4497580_2 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001275 285.0
HFD2_k127_4497580_3 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000004255 166.0
HFD2_k127_4497580_4 RESPONSE REGULATOR receiver - - - 0.00000000000003301 72.0
HFD2_k127_4511327_0 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009514 537.0
HFD2_k127_4511327_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 436.0
HFD2_k127_4511327_10 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000002533 219.0
HFD2_k127_4511327_11 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000116 208.0
HFD2_k127_4511327_12 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000000000000000000003257 200.0
HFD2_k127_4511327_13 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000003548 194.0
HFD2_k127_4511327_14 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000001089 196.0
HFD2_k127_4511327_15 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000007695 160.0
HFD2_k127_4511327_16 SnoaL-like domain K06893 - - 0.000000000000000000000000000000000000000003126 158.0
HFD2_k127_4511327_17 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000001015 166.0
HFD2_k127_4511327_18 Cupin domain - - - 0.00000000000000000000000000000000000000001896 167.0
HFD2_k127_4511327_19 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000009365 153.0
HFD2_k127_4511327_2 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 394.0
HFD2_k127_4511327_21 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000000004422 143.0
HFD2_k127_4511327_22 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000009458 113.0
HFD2_k127_4511327_23 Psort location Cytoplasmic, score - - - 0.0000000000000000000006886 101.0
HFD2_k127_4511327_24 FR47-like protein - - - 0.00000000000000000009982 100.0
HFD2_k127_4511327_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000005023 83.0
HFD2_k127_4511327_26 Domain of unknown function (DUF4440) - - - 0.000000000001596 79.0
HFD2_k127_4511327_27 - - - - 0.000000000001954 72.0
HFD2_k127_4511327_28 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.0000000001539 62.0
HFD2_k127_4511327_29 - - - - 0.00000003648 61.0
HFD2_k127_4511327_3 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006473 361.0
HFD2_k127_4511327_4 dihydrofolate reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 329.0
HFD2_k127_4511327_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 314.0
HFD2_k127_4511327_6 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001832 260.0
HFD2_k127_4511327_7 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001091 239.0
HFD2_k127_4511327_8 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000412 232.0
HFD2_k127_4511327_9 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000000000000000000006783 216.0
HFD2_k127_4513329_0 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 400.0
HFD2_k127_4513329_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000002503 162.0
HFD2_k127_4513329_3 Tetratricopeptide repeat - - - 0.00000002085 68.0
HFD2_k127_4515102_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1167.0
HFD2_k127_4515102_1 Peptidase M16 - - - 0.0 1147.0
HFD2_k127_4515102_10 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 362.0
HFD2_k127_4515102_11 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 358.0
HFD2_k127_4515102_12 AAA domain (Cdc48 subfamily) K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001452 285.0
HFD2_k127_4515102_13 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000175 289.0
HFD2_k127_4515102_14 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000493 242.0
HFD2_k127_4515102_15 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 - 3.1.11.2,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000009007 233.0
HFD2_k127_4515102_16 Belongs to the selenophosphate synthase 1 family. Class I subfamily K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000009513 231.0
HFD2_k127_4515102_17 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000004159 200.0
HFD2_k127_4515102_18 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000003601 198.0
HFD2_k127_4515102_19 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000004151 188.0
HFD2_k127_4515102_2 AAA-like domain - - - 2.464e-273 862.0
HFD2_k127_4515102_20 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000000009175 145.0
HFD2_k127_4515102_21 - - - - 0.000000000000000000000000000000002922 143.0
HFD2_k127_4515102_22 - - - - 0.00000000000000000000000003023 118.0
HFD2_k127_4515102_23 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000005095 103.0
HFD2_k127_4515102_24 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000814 91.0
HFD2_k127_4515102_25 Biopolymer transport protein ExbD/TolR K03559 - - 0.000000000000000007164 89.0
HFD2_k127_4515102_26 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K05970 - 3.1.1.53 0.000000002878 72.0
HFD2_k127_4515102_27 Cysteine-rich CPXCG - - - 0.00000004563 59.0
HFD2_k127_4515102_28 Tetratricopeptide TPR-1 - - - 0.00001365 57.0
HFD2_k127_4515102_3 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 1.498e-247 783.0
HFD2_k127_4515102_4 Belongs to the peptidase S16 family K01338,K04076,K04770 - 3.4.21.53 2.934e-221 715.0
HFD2_k127_4515102_5 Sodium:neurotransmitter symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 595.0
HFD2_k127_4515102_6 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 472.0
HFD2_k127_4515102_7 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 404.0
HFD2_k127_4515102_8 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 392.0
HFD2_k127_4515102_9 SMART Tetratricopeptide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 386.0
HFD2_k127_4515684_0 ABC transporter - - - 4.622e-263 823.0
HFD2_k127_4515684_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.269e-253 814.0
HFD2_k127_4515684_10 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 359.0
HFD2_k127_4515684_11 epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 318.0
HFD2_k127_4515684_12 Glycogen recognition site of AMP-activated protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 304.0
HFD2_k127_4515684_13 PFAM virulence factor family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001773 316.0
HFD2_k127_4515684_14 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009077 293.0
HFD2_k127_4515684_15 3-oxo-5-alpha-steroid 4-dehydrogenase K12343 - 1.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000007797 267.0
HFD2_k127_4515684_16 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000002822 227.0
HFD2_k127_4515684_17 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000002627 212.0
HFD2_k127_4515684_18 Putative esterase K07214 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008849,GO:0009056,GO:0009237,GO:0009238,GO:0009712,GO:0009987,GO:0016787,GO:0016788,GO:0018958,GO:0019336,GO:0019439,GO:0019614,GO:0019748,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046214,GO:0046215,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0071704,GO:0090487,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 - 0.000000000000000000000000000000000000000000000000000000001402 217.0
HFD2_k127_4515684_19 hemolysin - - - 0.00000000000000000000000000000000000000000000000000000001038 216.0
HFD2_k127_4515684_2 Alpha/beta hydrolase family - - - 3.351e-224 735.0
HFD2_k127_4515684_20 Mo-molybdopterin cofactor biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000005289 203.0
HFD2_k127_4515684_21 Acyl-transferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000003439 207.0
HFD2_k127_4515684_22 Belongs to the peptidase S8 family K08651,K14743 - 3.4.21.66 0.00000000000000000000000000000000000000000000000001144 199.0
HFD2_k127_4515684_23 Iron-storage protein K02217 - 1.16.3.2 0.00000000000000000000000000000000000002779 153.0
HFD2_k127_4515684_24 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000313 163.0
HFD2_k127_4515684_25 Sigma-70 region 2 - - - 0.00000000000000000000000000000000005123 141.0
HFD2_k127_4515684_26 Cupin 2, conserved barrel domain protein K11477 - - 0.0000000000000000000000000000000001609 139.0
HFD2_k127_4515684_27 - - - - 0.0000000000000000000000000000006517 134.0
HFD2_k127_4515684_28 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000007767 141.0
HFD2_k127_4515684_29 Haem-degrading - - - 0.00000000000000000000000000002645 123.0
HFD2_k127_4515684_3 gluconolactonase activity K01053 - 3.1.1.17 1.484e-203 654.0
HFD2_k127_4515684_30 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000106 135.0
HFD2_k127_4515684_31 DinB family - - - 0.00000000000000000000178 108.0
HFD2_k127_4515684_32 - - - - 0.000000000000000000005727 109.0
HFD2_k127_4515684_33 - - - - 0.00000000000000000003389 98.0
HFD2_k127_4515684_34 Protein of unknown function, DUF255 - - - 0.00000000000000000006842 98.0
HFD2_k127_4515684_35 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000701 105.0
HFD2_k127_4515684_36 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000002155 84.0
HFD2_k127_4515684_37 Carboxypeptidase regulatory-like domain - - - 0.0000000000000001101 95.0
HFD2_k127_4515684_38 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source K10778 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944 2.1.1.63 0.0000000000000001443 82.0
HFD2_k127_4515684_39 Bacterial virulence protein (VirJ) - - - 0.0000000000000003288 88.0
HFD2_k127_4515684_4 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008499 505.0
HFD2_k127_4515684_40 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000000001726 87.0
HFD2_k127_4515684_41 TonB dependent receptor K16089 - - 0.00000000000026 85.0
HFD2_k127_4515684_43 Cell surface - - - 0.000001292 62.0
HFD2_k127_4515684_44 CAAX protease self-immunity K07052 - - 0.00000133 61.0
HFD2_k127_4515684_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 485.0
HFD2_k127_4515684_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000913 431.0
HFD2_k127_4515684_7 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 426.0
HFD2_k127_4515684_8 ABC transporter transmembrane region K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 391.0
HFD2_k127_4515684_9 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 401.0
HFD2_k127_4521578_0 PFAM iron-containing alcohol dehydrogenase K00005 - 1.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 552.0
HFD2_k127_4521578_1 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 405.0
HFD2_k127_4521578_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 378.0
HFD2_k127_4521578_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.0000000000000000000000000000000000000000000000000000000000000000001267 237.0
HFD2_k127_4521578_4 Carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000007524 201.0
HFD2_k127_4521578_5 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000004236 156.0
HFD2_k127_4521578_6 Transcriptional regulator - - - 0.00000002007 63.0
HFD2_k127_4521578_7 YCII-related domain - - - 0.00000479 55.0
HFD2_k127_4522411_1 Cupin domain - - - 0.00000000000000000000000000000000000000000000944 167.0
HFD2_k127_4522411_2 PFAM Tetratricopeptide repeat - - - 0.00000000000000005606 94.0
HFD2_k127_4522411_3 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000002988 76.0
HFD2_k127_4522411_4 ECF sigma factor K03088 - - 0.0000005568 59.0
HFD2_k127_4544683_0 Oxidoreductase molybdopterin binding K00387 - 1.8.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 320.0
HFD2_k127_4544683_1 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.0000000000000000000000000000000000000002632 157.0
HFD2_k127_4544683_2 Cysteine dioxygenase type I - - - 0.00000000000000000000000000000000000171 149.0
HFD2_k127_4544683_3 PFAM Formylglycine-generating sulfatase enzyme K20333 - - 0.00000000000000000000000000000000001167 155.0
HFD2_k127_4544683_4 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000009304 151.0
HFD2_k127_4554922_0 Cupin domain - - - 0.000000000000000000000000000000000000000005868 157.0
HFD2_k127_4554922_1 lipolytic protein G-D-S-L family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000002286 118.0
HFD2_k127_4554922_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000001659 107.0
HFD2_k127_4554922_3 capsule polysaccharide biosynthetic process - - - 0.0000000000000000000352 98.0
HFD2_k127_4554922_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000003884 96.0
HFD2_k127_4554922_5 - - - - 0.0009424 46.0
HFD2_k127_4585013_0 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 1.031e-236 745.0
HFD2_k127_4585013_1 Formiminotransferase-cyclodeaminase K00603,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 462.0
HFD2_k127_4585013_10 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.0000000000000000000000000001202 117.0
HFD2_k127_4585013_11 Cysteine-rich secretory protein family - - - 0.0000000000000000000000006692 116.0
HFD2_k127_4585013_2 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 429.0
HFD2_k127_4585013_3 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 415.0
HFD2_k127_4585013_4 Belongs to the ClpA ClpB family K03694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 361.0
HFD2_k127_4585013_5 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 396.0
HFD2_k127_4585013_6 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01885,K01894 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 358.0
HFD2_k127_4585013_7 Fic/DOC family - - - 0.0000000000000000000000000000000000000000000000000000002304 207.0
HFD2_k127_4585013_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000002841 153.0
HFD2_k127_4585013_9 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000002432 150.0
HFD2_k127_4594650_0 AcrB/AcrD/AcrF family K15726 - - 0.0 1413.0
HFD2_k127_4594650_2 Hep Hag repeat protein - - - 0.0000002918 63.0
HFD2_k127_4619079_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 387.0
HFD2_k127_4619079_1 Formyl transferase K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000005121 211.0
HFD2_k127_4619079_2 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000004247 185.0
HFD2_k127_4619079_3 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000001521 199.0
HFD2_k127_4619079_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000006697 115.0
HFD2_k127_4619079_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0003924 53.0
HFD2_k127_4729619_0 Dehydrogenase E1 component K00164 - 1.2.4.2 8.845e-299 942.0
HFD2_k127_4729619_1 nickel-dependent hydrogenase, large subunit K06281 - 1.12.99.6 8.757e-282 874.0
HFD2_k127_4729619_10 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 459.0
HFD2_k127_4729619_11 AIR synthase related protein, C-terminal domain K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 412.0
HFD2_k127_4729619_12 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 371.0
HFD2_k127_4729619_13 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 344.0
HFD2_k127_4729619_14 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 330.0
HFD2_k127_4729619_15 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002887 324.0
HFD2_k127_4729619_16 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 299.0
HFD2_k127_4729619_17 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004838 305.0
HFD2_k127_4729619_18 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000252 274.0
HFD2_k127_4729619_19 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001396 271.0
HFD2_k127_4729619_2 Belongs to the carbamoyltransferase HypF family K04656 - - 5.214e-247 784.0
HFD2_k127_4729619_20 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003325 276.0
HFD2_k127_4729619_21 PFAM RNA binding S1 domain protein K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000031 247.0
HFD2_k127_4729619_22 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000114 236.0
HFD2_k127_4729619_23 PFAM Cation transporter K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000006673 255.0
HFD2_k127_4729619_24 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000004558 225.0
HFD2_k127_4729619_25 Glycine cleavage H-protein - - - 0.0000000000000000000000000000000000000000000000000003478 194.0
HFD2_k127_4729619_26 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000005006 186.0
HFD2_k127_4729619_27 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.000000000000000000000000000000000000000000000383 174.0
HFD2_k127_4729619_28 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000001516 181.0
HFD2_k127_4729619_29 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000000773 166.0
HFD2_k127_4729619_3 PFAM MMPL family K07003 - - 5.097e-230 736.0
HFD2_k127_4729619_30 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000007883 166.0
HFD2_k127_4729619_31 Vitamin K epoxide reductase family - - - 0.000000000000000000000000000000000000001531 168.0
HFD2_k127_4729619_32 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000005325 145.0
HFD2_k127_4729619_33 Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000029 149.0
HFD2_k127_4729619_34 glycine decarboxylation via glycine cleavage system K02437 - - 0.0000000000000000000000000000000004584 144.0
HFD2_k127_4729619_35 HupF/HypC family K04653 - - 0.0000000000000000000383 99.0
HFD2_k127_4729619_36 nickel cation binding K04651 - - 0.000000000000000009011 85.0
HFD2_k127_4729619_37 Methyltransferase domain - - - 0.0000000000002584 82.0
HFD2_k127_4729619_39 Uncharacterized protein conserved in bacteria (DUF2062) - - - 0.0000008491 61.0
HFD2_k127_4729619_4 PFAM response regulator receiver K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 617.0
HFD2_k127_4729619_40 Mechanosensitive ion channel - - - 0.00000112 61.0
HFD2_k127_4729619_5 iron-nicotianamine transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 573.0
HFD2_k127_4729619_6 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 535.0
HFD2_k127_4729619_7 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 527.0
HFD2_k127_4729619_8 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 484.0
HFD2_k127_4729619_9 HAMP domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 494.0
HFD2_k127_47385_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1203.0
HFD2_k127_47385_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 6.992e-219 690.0
HFD2_k127_47385_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 287.0
HFD2_k127_47385_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000082 220.0
HFD2_k127_47385_12 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000000000000003483 126.0
HFD2_k127_47385_13 - - - - 0.0000000000000000000000000000001564 127.0
HFD2_k127_47385_14 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000007414 128.0
HFD2_k127_47385_15 - - - - 0.0000000000000000000000001682 112.0
HFD2_k127_47385_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00332 - 1.6.5.3 0.0000000000000000000000004894 111.0
HFD2_k127_47385_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.000000000000000000002604 98.0
HFD2_k127_47385_18 4Fe-4S dicluster domain K03941 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.6.5.3,1.6.99.3 0.000000000000000000004785 108.0
HFD2_k127_47385_19 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000007335 93.0
HFD2_k127_47385_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 569.0
HFD2_k127_47385_20 permease, DMT superfamily K11939 - - 0.000000000000000004499 96.0
HFD2_k127_47385_21 Belongs to the complex I subunit 6 family K00339,K05578 - 1.6.5.3 0.00000000000000009966 92.0
HFD2_k127_47385_22 - - - - 0.000000000000001407 85.0
HFD2_k127_47385_23 Transcriptional regulator - - - 0.000000000000002318 80.0
HFD2_k127_47385_24 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000004192 79.0
HFD2_k127_47385_25 - - - - 0.000003538 56.0
HFD2_k127_47385_3 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 576.0
HFD2_k127_47385_4 NADH-quinone oxidoreductase chain L K00341,K05577 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 533.0
HFD2_k127_47385_5 Proton-conducting membrane transporter K00342,K05575 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 525.0
HFD2_k127_47385_6 NAD binding K00333,K05579,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006256 412.0
HFD2_k127_47385_7 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 344.0
HFD2_k127_47385_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 329.0
HFD2_k127_47385_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343,K05573 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 329.0
HFD2_k127_4745268_0 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000002043 243.0
HFD2_k127_4745268_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000005414 192.0
HFD2_k127_4745268_2 TIGRFAM DNA repair protein RadC K03630 - - 0.000000000000000000000000000000002398 139.0
HFD2_k127_4827584_0 nitrite transmembrane transporter activity - - - 9.554e-316 985.0
HFD2_k127_4827584_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 3.166e-291 917.0
HFD2_k127_4827584_10 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000001802 211.0
HFD2_k127_4827584_11 Putative regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000004846 203.0
HFD2_k127_4827584_12 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000009428 180.0
HFD2_k127_4827584_13 amino acid - - - 0.00000000000000000000000000000000000000000003887 181.0
HFD2_k127_4827584_14 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000007432 160.0
HFD2_k127_4827584_15 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000005633 151.0
HFD2_k127_4827584_16 HD domain - - - 0.000000000000000000000000000008173 126.0
HFD2_k127_4827584_17 regulation of cell-substrate adhesion K06079 - - 0.00000000000002803 80.0
HFD2_k127_4827584_18 PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - 0.00000000001345 69.0
HFD2_k127_4827584_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.681e-258 809.0
HFD2_k127_4827584_20 ankyrin repeat K21440 - - 0.0000001055 62.0
HFD2_k127_4827584_21 Hemerythrin HHE cation binding - - - 0.0000001649 59.0
HFD2_k127_4827584_22 - - - - 0.00000737 56.0
HFD2_k127_4827584_23 PFAM Tetratricopeptide - - - 0.000007442 58.0
HFD2_k127_4827584_25 cellulase activity - - - 0.0003992 54.0
HFD2_k127_4827584_26 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000449 52.0
HFD2_k127_4827584_27 COG0457 FOG TPR repeat - - - 0.0007853 51.0
HFD2_k127_4827584_3 Glycoside hydrolase, family 20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 605.0
HFD2_k127_4827584_4 PFAM Rieske 2Fe-2S domain protein K00479,K00499,K05708 - 1.14.12.19,1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 348.0
HFD2_k127_4827584_5 Belongs to the glycosyl hydrolase 26 family K01179 GO:0003674,GO:0003824,GO:0004553,GO:0008810,GO:0016787,GO:0016798 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 303.0
HFD2_k127_4827584_6 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001773 287.0
HFD2_k127_4827584_7 RNA polymerase recycling family C-terminal K03580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001558 297.0
HFD2_k127_4827584_8 SMART PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001012 269.0
HFD2_k127_4827584_9 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000001219 246.0
HFD2_k127_4838330_0 Domain of unknown function (DUF3372) K01200 - 3.2.1.41 0.0 1219.0
HFD2_k127_4838330_1 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000002748 174.0
HFD2_k127_4838330_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000003324 72.0
HFD2_k127_4927003_0 zinc ion binding K12035 - 2.3.2.27 0.0000000005945 71.0
HFD2_k127_4947991_0 Amidohydrolase family - - - 4.466e-277 888.0
HFD2_k127_4947991_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 5.332e-247 780.0
HFD2_k127_4947991_10 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000002705 156.0
HFD2_k127_4947991_11 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000000002769 119.0
HFD2_k127_4947991_12 Domain of unknown function (DUF4382) - - - 0.000000002804 66.0
HFD2_k127_4947991_13 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein - - - 0.000000005767 68.0
HFD2_k127_4947991_2 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 573.0
HFD2_k127_4947991_3 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 421.0
HFD2_k127_4947991_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 314.0
HFD2_k127_4947991_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 309.0
HFD2_k127_4947991_6 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000005913 244.0
HFD2_k127_4947991_7 Bacterial PH domain - - - 0.0000000000000000000000000000000000000000000000000000000005598 214.0
HFD2_k127_4947991_8 Bacterial PH domain K08981 - - 0.000000000000000000000000000000000000000000000002336 187.0
HFD2_k127_4947991_9 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000602 183.0
HFD2_k127_5063063_0 Peptidase family C25 - - - 0.00000000000000000000000000000000000000005245 175.0
HFD2_k127_5063063_1 collagen metabolic process K08677 - - 0.000000000000001025 92.0
HFD2_k127_5067798_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.085e-250 789.0
HFD2_k127_5067798_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 469.0
HFD2_k127_5067798_10 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000536 237.0
HFD2_k127_5067798_11 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000001026 236.0
HFD2_k127_5067798_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000369 141.0
HFD2_k127_5067798_13 Peptidase family M23 K21471 - - 0.000000000000000000000000000000001584 149.0
HFD2_k127_5067798_14 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000003555 143.0
HFD2_k127_5067798_15 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000000001576 98.0
HFD2_k127_5067798_16 - - - - 0.00000000000669 79.0
HFD2_k127_5067798_17 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000005482 61.0
HFD2_k127_5067798_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 445.0
HFD2_k127_5067798_3 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 445.0
HFD2_k127_5067798_4 TIGRFAM carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 433.0
HFD2_k127_5067798_5 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 416.0
HFD2_k127_5067798_6 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 417.0
HFD2_k127_5067798_7 Domain of unknown function (DUF3552) K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 385.0
HFD2_k127_5067798_8 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 374.0
HFD2_k127_5067798_9 metallophosphoesterase K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001857 302.0
HFD2_k127_5275103_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 654.0
HFD2_k127_5275103_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 609.0
HFD2_k127_5275103_10 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006876 383.0
HFD2_k127_5275103_11 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 316.0
HFD2_k127_5275103_12 Integral membrane protein TerC family K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 318.0
HFD2_k127_5275103_13 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 316.0
HFD2_k127_5275103_14 Nad-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 301.0
HFD2_k127_5275103_15 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004516 289.0
HFD2_k127_5275103_16 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005723 273.0
HFD2_k127_5275103_17 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000002385 247.0
HFD2_k127_5275103_18 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000004543 242.0
HFD2_k127_5275103_19 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000004958 184.0
HFD2_k127_5275103_2 prohibitin homologues K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 521.0
HFD2_k127_5275103_20 PFAM amino acid permease-associated region K03294 - - 0.000000000000000000000000000000000000000000000002339 190.0
HFD2_k127_5275103_21 hydrolase of the alpha beta-hydrolase fold K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - 0.0000000000000000000000000000000000000000001223 181.0
HFD2_k127_5275103_22 Protein-disulfide isomerase - - - 0.000000000000000000000000000000000000000002699 159.0
HFD2_k127_5275103_23 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000006415 153.0
HFD2_k127_5275103_24 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000004143 139.0
HFD2_k127_5275103_25 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000001302 139.0
HFD2_k127_5275103_26 - - - - 0.00000000000000000001083 106.0
HFD2_k127_5275103_27 SAM-dependent methyltransferase K06967 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.217 0.0000000000000000001437 98.0
HFD2_k127_5275103_28 Protein of unknown function (DUF2892) - - - 0.000000000000000002672 87.0
HFD2_k127_5275103_29 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000001326 88.0
HFD2_k127_5275103_3 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 480.0
HFD2_k127_5275103_31 - - - - 0.0000000000001124 77.0
HFD2_k127_5275103_33 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000007995 64.0
HFD2_k127_5275103_34 oxidoreductase activity - - - 0.0001189 55.0
HFD2_k127_5275103_35 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0001556 55.0
HFD2_k127_5275103_4 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 505.0
HFD2_k127_5275103_5 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 419.0
HFD2_k127_5275103_6 Mitochondrial biogenesis AIM24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 418.0
HFD2_k127_5275103_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 396.0
HFD2_k127_5275103_8 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 371.0
HFD2_k127_5275103_9 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 380.0
HFD2_k127_5280346_0 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009346 465.0
HFD2_k127_5280346_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 451.0
HFD2_k127_5284865_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1089.0
HFD2_k127_5284865_1 GTP-binding protein TypA K06207 - - 4.363e-262 822.0
HFD2_k127_5284865_10 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 458.0
HFD2_k127_5284865_100 Cellulase (glycosyl hydrolase family 5) - - - 0.000001245 57.0
HFD2_k127_5284865_101 SMART helix-turn-helix domain protein - - - 0.000002056 54.0
HFD2_k127_5284865_102 STAS domain - - - 0.00008936 55.0
HFD2_k127_5284865_103 NHL repeat - - - 0.0002424 53.0
HFD2_k127_5284865_104 PFAM Peptidase S24 S26A S26B, conserved region - - - 0.0002845 51.0
HFD2_k127_5284865_105 Protein kinase domain - - - 0.0003572 53.0
HFD2_k127_5284865_107 cell adhesion involved in biofilm formation - - - 0.0005693 53.0
HFD2_k127_5284865_108 Type II secretion system (T2SS), protein G K02456 - - 0.0006342 51.0
HFD2_k127_5284865_11 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009121 447.0
HFD2_k127_5284865_12 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 458.0
HFD2_k127_5284865_13 Domain of unknown function (DUF3552) K18682 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 446.0
HFD2_k127_5284865_14 PFAM Acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 404.0
HFD2_k127_5284865_15 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 437.0
HFD2_k127_5284865_16 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 421.0
HFD2_k127_5284865_17 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 415.0
HFD2_k127_5284865_18 Thiolase, C-terminal domain K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 384.0
HFD2_k127_5284865_19 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 399.0
HFD2_k127_5284865_2 Elongation factor G, domain IV K02355 - - 1.105e-232 739.0
HFD2_k127_5284865_20 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 376.0
HFD2_k127_5284865_21 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 371.0
HFD2_k127_5284865_22 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 366.0
HFD2_k127_5284865_23 SPFH domain-Band 7 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 333.0
HFD2_k127_5284865_24 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 353.0
HFD2_k127_5284865_25 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family K13687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 314.0
HFD2_k127_5284865_26 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 304.0
HFD2_k127_5284865_27 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006537 287.0
HFD2_k127_5284865_28 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003804 291.0
HFD2_k127_5284865_29 PFAM peptidase T2 asparaginase 2 K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000003364 276.0
HFD2_k127_5284865_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.032e-214 676.0
HFD2_k127_5284865_30 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003971 288.0
HFD2_k127_5284865_31 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000001835 286.0
HFD2_k127_5284865_32 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004219 266.0
HFD2_k127_5284865_33 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000005898 267.0
HFD2_k127_5284865_34 Protein of unknown function (DUF2400) K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 263.0
HFD2_k127_5284865_35 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K04068,K10026 - 1.97.1.4,4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000002007 254.0
HFD2_k127_5284865_36 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000003283 257.0
HFD2_k127_5284865_37 Belongs to the peptidase S8 family K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001248 264.0
HFD2_k127_5284865_38 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007399 244.0
HFD2_k127_5284865_39 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000932 251.0
HFD2_k127_5284865_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 645.0
HFD2_k127_5284865_40 Squalene/phytoene synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003027 246.0
HFD2_k127_5284865_41 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000001754 264.0
HFD2_k127_5284865_42 serine acetyltransferase K00640 GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016053,GO:0016054,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000001892 243.0
HFD2_k127_5284865_43 'Molybdopterin K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000008101 257.0
HFD2_k127_5284865_44 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000009794 248.0
HFD2_k127_5284865_45 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000007892 231.0
HFD2_k127_5284865_46 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000009978 221.0
HFD2_k127_5284865_47 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000002205 210.0
HFD2_k127_5284865_48 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000000000000000006516 210.0
HFD2_k127_5284865_49 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000001228 204.0
HFD2_k127_5284865_5 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 567.0
HFD2_k127_5284865_50 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000001279 220.0
HFD2_k127_5284865_51 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000001494 201.0
HFD2_k127_5284865_52 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000007798 214.0
HFD2_k127_5284865_53 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000002343 214.0
HFD2_k127_5284865_54 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000002841 200.0
HFD2_k127_5284865_55 Glycosyl transferase family 2 K12984 - - 0.000000000000000000000000000000000000000000000000000009691 201.0
HFD2_k127_5284865_56 DHH family K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000002101 208.0
HFD2_k127_5284865_57 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000007905 196.0
HFD2_k127_5284865_58 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000007517 177.0
HFD2_k127_5284865_59 Rhomboid family - - - 0.000000000000000000000000000000000000000000009807 173.0
HFD2_k127_5284865_6 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 563.0
HFD2_k127_5284865_60 Bacterial transferase hexapeptide (six repeats) K02617 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008270,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043168,GO:0043169,GO:0043199,GO:0046872,GO:0046914,GO:0050897,GO:0071890,GO:1901681 - 0.00000000000000000000000000000000000000000004301 175.0
HFD2_k127_5284865_61 Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000739 175.0
HFD2_k127_5284865_62 Small GTP-binding protein K06883 - - 0.00000000000000000000000000000000000000000187 178.0
HFD2_k127_5284865_63 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000009138 173.0
HFD2_k127_5284865_64 DNA polymerase III K02341 - 2.7.7.7 0.0000000000000000000000000000000000000001537 171.0
HFD2_k127_5284865_65 MoaE protein K21142 - 2.8.1.12 0.0000000000000000000000000000000000000002806 153.0
HFD2_k127_5284865_66 NYN domain - - - 0.0000000000000000000000000000000000001314 160.0
HFD2_k127_5284865_67 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000001517 153.0
HFD2_k127_5284865_68 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000000000000000000001881 160.0
HFD2_k127_5284865_69 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000079 160.0
HFD2_k127_5284865_7 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 553.0
HFD2_k127_5284865_70 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.0000000000000000000000000000000000009327 155.0
HFD2_k127_5284865_71 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000005574 146.0
HFD2_k127_5284865_72 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000551 140.0
HFD2_k127_5284865_73 Exonuclease - - - 0.0000000000000000000000000000000007911 141.0
HFD2_k127_5284865_74 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000923 147.0
HFD2_k127_5284865_75 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000005195 134.0
HFD2_k127_5284865_76 Histidine kinase A domain protein K03407 - 2.7.13.3 0.00000000000000000000000000000006115 144.0
HFD2_k127_5284865_77 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000005473 120.0
HFD2_k127_5284865_78 cheY-homologous receiver domain - - - 0.0000000000000000000000000001083 134.0
HFD2_k127_5284865_79 Hydrolase, P-loop family K06925 - - 0.00000000000000000000000003356 126.0
HFD2_k127_5284865_8 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 536.0
HFD2_k127_5284865_80 Binds the 23S rRNA K02909 - - 0.00000000000000000000000003384 111.0
HFD2_k127_5284865_81 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000001792 114.0
HFD2_k127_5284865_82 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000005105 104.0
HFD2_k127_5284865_83 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000005898 101.0
HFD2_k127_5284865_84 ATP synthase F(0) sector subunit b K02109 - - 0.000000000000000000001151 102.0
HFD2_k127_5284865_85 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000002959 99.0
HFD2_k127_5284865_86 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000002656 97.0
HFD2_k127_5284865_87 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000001187 94.0
HFD2_k127_5284865_88 Hfq protein K03666 - - 0.000000000000003262 78.0
HFD2_k127_5284865_9 PFAM acyl-CoA dehydrogenase domain protein K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 502.0
HFD2_k127_5284865_90 - - - - 0.00000000000002175 88.0
HFD2_k127_5284865_91 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000001187 66.0
HFD2_k127_5284865_92 peptidase M48, Ste24p - - - 0.00000000001578 76.0
HFD2_k127_5284865_93 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00000000008382 65.0
HFD2_k127_5284865_94 - - - - 0.0000000005973 66.0
HFD2_k127_5284865_95 PBS lyase K22221 - - 0.0000000008661 71.0
HFD2_k127_5284865_96 PFAM molybdopterin biosynthesis MoaE protein K03635,K21142 - 2.8.1.12 0.00000003294 65.0
HFD2_k127_5284865_97 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000003683 66.0
HFD2_k127_5284865_98 His Kinase A (phosphoacceptor) domain K10942 - 2.7.13.3 0.0000008431 63.0
HFD2_k127_5284865_99 Histidine kinase - - - 0.0000009465 58.0
HFD2_k127_5296694_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 4.963e-247 786.0
HFD2_k127_5296694_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.362e-218 706.0
HFD2_k127_5296694_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000009884 110.0
HFD2_k127_5296694_11 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000003318 104.0
HFD2_k127_5296694_12 protein conserved in bacteria K09764 - - 0.000000000004276 71.0
HFD2_k127_5296694_13 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03646,K03832 - - 0.00001325 57.0
HFD2_k127_5296694_2 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 414.0
HFD2_k127_5296694_3 DEAD DEAH box helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 340.0
HFD2_k127_5296694_4 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002547 275.0
HFD2_k127_5296694_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000007769 191.0
HFD2_k127_5296694_6 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.00000000000000000000000000000000000000008222 168.0
HFD2_k127_5296694_7 positive regulation of growth rate - - - 0.0000000000000000000000000000000000133 149.0
HFD2_k127_5296694_8 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000004626 133.0
HFD2_k127_5296694_9 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.000000000000000000000000000003258 138.0
HFD2_k127_531323_0 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 607.0
HFD2_k127_531323_1 PFAM acyl-CoA dehydrogenase domain protein K00249,K11731 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 472.0
HFD2_k127_531323_10 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000003567 225.0
HFD2_k127_531323_11 DGC domain - - - 0.0000000000000000000000000000000000000000000000000003059 193.0
HFD2_k127_531323_12 DoxX - - - 0.000000000000000000000000000000000000000000000001704 185.0
HFD2_k127_531323_13 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006807,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0020037,GO:0042279,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0097164,GO:0098809,GO:1901363 - 0.00000000000000000000000000000000000001231 166.0
HFD2_k127_531323_14 Protein of unknown function (DUF3313) - - - 0.0000000000000000000000000000000000002011 151.0
HFD2_k127_531323_15 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000004302 138.0
HFD2_k127_531323_16 - - - - 0.0000000000000000000000000006039 117.0
HFD2_k127_531323_17 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000001482 117.0
HFD2_k127_531323_18 rRNA processing K09140 - - 0.0000000000000000000000002327 111.0
HFD2_k127_531323_19 FG-GAP repeat protein - - - 0.000000000000000000000001353 117.0
HFD2_k127_531323_2 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 475.0
HFD2_k127_531323_20 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000008128 105.0
HFD2_k127_531323_21 TonB-dependent receptor K02014 - - 0.00000000000000003875 89.0
HFD2_k127_531323_22 Thiopurine S-methyltransferase (TPMT) - - - 0.0000000000001941 79.0
HFD2_k127_531323_3 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 462.0
HFD2_k127_531323_4 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 349.0
HFD2_k127_531323_5 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 339.0
HFD2_k127_531323_6 region 4 type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002204 284.0
HFD2_k127_531323_7 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000008791 264.0
HFD2_k127_531323_8 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000001187 263.0
HFD2_k127_531323_9 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000008986 225.0
HFD2_k127_5320312_0 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 580.0
HFD2_k127_5320312_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 552.0
HFD2_k127_5320312_2 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 413.0
HFD2_k127_5320312_4 ribonuclease activity - - - 0.0000000000000000000001169 106.0
HFD2_k127_5320312_5 Fibronectin type 3 domain - - - 0.0001095 54.0
HFD2_k127_5327748_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5e-324 1012.0
HFD2_k127_5327748_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008150,GO:0008152,GO:0009295,GO:0009330,GO:0009987,GO:0016043,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.99.1.3 2.238e-265 851.0
HFD2_k127_5327748_10 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 402.0
HFD2_k127_5327748_11 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 316.0
HFD2_k127_5327748_12 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 302.0
HFD2_k127_5327748_13 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 317.0
HFD2_k127_5327748_14 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002814 298.0
HFD2_k127_5327748_15 Tryptophan halogenase K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009805 285.0
HFD2_k127_5327748_16 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001561 286.0
HFD2_k127_5327748_17 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000507 254.0
HFD2_k127_5327748_18 (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005446 261.0
HFD2_k127_5327748_19 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006143 261.0
HFD2_k127_5327748_2 FeoA - - - 1.34e-248 800.0
HFD2_k127_5327748_20 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000003604 258.0
HFD2_k127_5327748_21 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000005017 228.0
HFD2_k127_5327748_22 Protein of unknown function (DUF423) - - - 0.000000000000000000000000000000000000000001513 158.0
HFD2_k127_5327748_23 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000004688 169.0
HFD2_k127_5327748_24 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000000004236 124.0
HFD2_k127_5327748_25 PFAM Cyclic nucleotide-binding K01420,K21563 - - 0.00000000000000000000000000002967 125.0
HFD2_k127_5327748_26 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000008154 108.0
HFD2_k127_5327748_27 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000009092 108.0
HFD2_k127_5327748_28 PFAM Single-stranded nucleic acid binding R3H K06346 - - 0.000000000000000000009653 102.0
HFD2_k127_5327748_29 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000002389 92.0
HFD2_k127_5327748_3 Carboxyl transferase domain K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 1.609e-240 767.0
HFD2_k127_5327748_30 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000008222 98.0
HFD2_k127_5327748_31 Biotin-requiring enzyme - - - 0.00000000000000003475 96.0
HFD2_k127_5327748_32 iron ion homeostasis K03322,K03709,K04758 - - 0.000000000000003407 78.0
HFD2_k127_5327748_33 - - - - 0.000000000000005022 80.0
HFD2_k127_5327748_34 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000113 80.0
HFD2_k127_5327748_35 PA14 domain - - - 0.00000000000002249 87.0
HFD2_k127_5327748_36 oxygen carrier activity K07216 - - 0.000000000000385 76.0
HFD2_k127_5327748_38 Polymer-forming cytoskeletal - - - 0.00000000004262 71.0
HFD2_k127_5327748_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.841e-199 629.0
HFD2_k127_5327748_40 SMART Transport-associated and nodulation region - - - 0.00000006743 63.0
HFD2_k127_5327748_41 Peptide-N-glycosidase F, C terminal - - - 0.00007265 56.0
HFD2_k127_5327748_5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 608.0
HFD2_k127_5327748_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 560.0
HFD2_k127_5327748_7 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 544.0
HFD2_k127_5327748_8 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 480.0
HFD2_k127_5327748_9 CAAX prenyl protease N-terminal, five membrane helices - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 443.0
HFD2_k127_5333096_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 445.0
HFD2_k127_5333096_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 382.0
HFD2_k127_5333096_2 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000001344 165.0
HFD2_k127_5333096_3 Lipid A Biosynthesis N-terminal domain - - - 0.00000000000000000000000000000000001704 137.0
HFD2_k127_5333096_4 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000007978 127.0
HFD2_k127_5333096_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000008091 119.0
HFD2_k127_5333096_6 Protein of unknown function (DUF971) K03593 - - 0.00000000000000000001171 106.0
HFD2_k127_5333096_7 Polymer-forming cytoskeletal - - - 0.000002058 59.0
HFD2_k127_5338086_0 Astacin (Peptidase family M12A) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 380.0
HFD2_k127_5338086_1 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 354.0
HFD2_k127_5338086_2 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001636 298.0
HFD2_k127_5338086_3 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009618 296.0
HFD2_k127_5338086_4 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000009653 247.0
HFD2_k127_5338086_5 regulation of methylation-dependent chromatin silencing K07454 - - 0.0000000000000000000000000000000000000000000000000000000000000001072 234.0
HFD2_k127_5338086_6 Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000000000000339 125.0
HFD2_k127_5338086_7 Helix-turn-helix domain - - - 0.00000000000000000002365 94.0
HFD2_k127_5338086_8 Protein of unknown function (DUF2442) - - - 0.000000000006371 69.0
HFD2_k127_5338086_9 Transcriptional regulator - - - 0.00000003499 62.0
HFD2_k127_5340846_0 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000723 258.0
HFD2_k127_5340846_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000002973 239.0
HFD2_k127_5340846_2 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000008571 164.0
HFD2_k127_5354515_0 Superfamily II DNA RNA helicases, SNF2 family - - - 0.0 1077.0
HFD2_k127_5354515_1 Amino acid permease - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 2.801e-267 838.0
HFD2_k127_5354515_10 pteridine-dependent deoxygenase - - - 0.00000000000000000000000000000000000000000000000000003526 200.0
HFD2_k127_5354515_11 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000000000000000000001012 213.0
HFD2_k127_5354515_12 SMART alpha amylase catalytic sub domain K01176 - 3.2.1.1 0.000000000000000000000000000000000000000000000000004463 202.0
HFD2_k127_5354515_13 TrkA-N domain K03499,K10716 - - 0.0000000000000000000000000000000000000000001177 184.0
HFD2_k127_5354515_14 - - - - 0.0000000000000000000000009875 111.0
HFD2_k127_5354515_15 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 - 2.1.1.63 0.0000000000000000000006034 100.0
HFD2_k127_5354515_16 Kelch motif - - - 0.0000000000001753 80.0
HFD2_k127_5354515_18 PFAM NAD dependent epimerase dehydratase family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000002141 66.0
HFD2_k127_5354515_19 Belongs to the glycosyl hydrolase family 6 - - - 0.000002056 54.0
HFD2_k127_5354515_2 H( )-stimulated, divalent metal cation uptake system K03322 - - 5.487e-211 674.0
HFD2_k127_5354515_3 Cytochrome bd-type quinol oxidase subunit 1 K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 571.0
HFD2_k127_5354515_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 482.0
HFD2_k127_5354515_5 COG1294 Cytochrome bd-type quinol oxidase subunit 2 K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007975 419.0
HFD2_k127_5354515_6 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007542 357.0
HFD2_k127_5354515_7 TrkA-C domain K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 288.0
HFD2_k127_5354515_8 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001339 283.0
HFD2_k127_5354515_9 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000106 256.0
HFD2_k127_5389810_0 Surface antigen K07277,K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 408.0
HFD2_k127_5398587_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 2.938e-252 785.0
HFD2_k127_5398587_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 568.0
HFD2_k127_5398587_10 Fatty acid desaturase K00508 - 1.14.19.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 363.0
HFD2_k127_5398587_11 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006677 283.0
HFD2_k127_5398587_12 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001202 262.0
HFD2_k127_5398587_13 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002493 274.0
HFD2_k127_5398587_14 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003413 249.0
HFD2_k127_5398587_15 Zn_pept K05996 - 3.4.17.18 0.0000000000000000000000000000000000000000000000000000000000000005978 250.0
HFD2_k127_5398587_16 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000003866 224.0
HFD2_k127_5398587_17 exo-alpha-(2->6)-sialidase activity K01406 - 3.4.24.40 0.00000000000000000000000000000000000000000000000000083 212.0
HFD2_k127_5398587_18 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000001954 189.0
HFD2_k127_5398587_19 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000002306 146.0
HFD2_k127_5398587_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 510.0
HFD2_k127_5398587_20 - - - - 0.000000000000000000000000000000002733 150.0
HFD2_k127_5398587_21 oligosaccharyl transferase activity - - - 0.0000000000000000000000000001751 132.0
HFD2_k127_5398587_22 Cartilage oligomeric matrix protein K04659 GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002020,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0008289,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010941,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0019842,GO:0019899,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030198,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0036094,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043394,GO:0043395,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048736,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060173,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0060548,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097159,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181 - 0.0000000000000000000000000007745 132.0
HFD2_k127_5398587_23 Vitamin K epoxide reductase family - - - 0.0000000000000000000000000009729 133.0
HFD2_k127_5398587_24 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000001273 114.0
HFD2_k127_5398587_25 4'-phosphopantetheinyl transferase superfamily K00997 - 2.7.8.7 0.00000000000000000000000004663 113.0
HFD2_k127_5398587_26 Multicopper oxidase - - - 0.000000000000000002214 102.0
HFD2_k127_5398587_27 cyclic nucleotide binding K10914 - - 0.000000000000000007291 94.0
HFD2_k127_5398587_28 CarboxypepD_reg-like domain K13276 - - 0.0000000000314 78.0
HFD2_k127_5398587_29 acyl carrier protein - - - 0.000000004842 61.0
HFD2_k127_5398587_3 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 490.0
HFD2_k127_5398587_30 PFAM glycoside hydrolase family 10 K01181 - 3.2.1.8 0.00000000591 70.0
HFD2_k127_5398587_31 pilus organization - - - 0.00000009359 65.0
HFD2_k127_5398587_32 Fibronectin type 3 domain - - - 0.0000003937 64.0
HFD2_k127_5398587_33 Protein of unknown function (DUF1571) - - - 0.000001887 59.0
HFD2_k127_5398587_34 calcium- and calmodulin-responsive adenylate cyclase activity K13735,K20276,K21449 - - 0.000006158 61.0
HFD2_k127_5398587_35 - - - - 0.00003613 50.0
HFD2_k127_5398587_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 440.0
HFD2_k127_5398587_5 Aminotransferase class-V K04127 - 5.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 446.0
HFD2_k127_5398587_6 cellulase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 462.0
HFD2_k127_5398587_7 geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 417.0
HFD2_k127_5398587_8 cellulase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 437.0
HFD2_k127_5398587_9 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 423.0
HFD2_k127_5449910_0 Belongs to the glycosyl hydrolase 2 family K01190 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000653 596.0
HFD2_k127_5449910_1 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000000000000000000000000003766 205.0
HFD2_k127_5452974_0 4Fe-4S dicluster domain K00184 - - 4.55e-322 1025.0
HFD2_k127_5452974_1 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 548.0
HFD2_k127_5452974_10 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000004295 252.0
HFD2_k127_5452974_11 Haem-binding domain - - - 0.000000000000000000000000000000000000000000000000000005437 196.0
HFD2_k127_5452974_12 Cytochrome c K00413 - - 0.00000000000000000000000000000000000000000000000000001053 216.0
HFD2_k127_5452974_13 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000171 191.0
HFD2_k127_5452974_14 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000002904 193.0
HFD2_k127_5452974_15 Protein of unknown function (DUF3179) - - - 0.000000000000000000000000000000000000000000205 171.0
HFD2_k127_5452974_16 protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000308 154.0
HFD2_k127_5452974_17 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000004149 147.0
HFD2_k127_5452974_18 Cytochrome oxidase assembly protein K02259,K03110 - - 0.00000000000000000000000000000102 137.0
HFD2_k127_5452974_19 Cytochrome c K02720 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0009521,GO:0009523,GO:0009579,GO:0016020,GO:0030075,GO:0030096,GO:0032991,GO:0034357,GO:0042651,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044425,GO:0044436,GO:0044444,GO:0044459,GO:0044464,GO:0071944,GO:0098796,GO:0098797 - 0.000000000000000000000000000006198 126.0
HFD2_k127_5452974_2 Rubrerythrin K22405 - 1.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 529.0
HFD2_k127_5452974_20 DoxX - - - 0.0000000000000000000000000002744 125.0
HFD2_k127_5452974_21 NIPSNAP - - - 0.0000000000000000000004157 106.0
HFD2_k127_5452974_22 - - - - 0.00000000000004886 87.0
HFD2_k127_5452974_23 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000006981 80.0
HFD2_k127_5452974_24 Putative regulatory protein - - - 0.0000000000007038 72.0
HFD2_k127_5452974_25 Methyltransferase - - - 0.0000000009595 64.0
HFD2_k127_5452974_26 Cytochrome c K02305 - - 0.0000003608 64.0
HFD2_k127_5452974_27 Cyclic nucleotide-monophosphate binding domain - - - 0.000002163 59.0
HFD2_k127_5452974_28 Acetyltransferase (GNAT) domain - - - 0.0003389 55.0
HFD2_k127_5452974_3 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 493.0
HFD2_k127_5452974_4 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 412.0
HFD2_k127_5452974_5 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 396.0
HFD2_k127_5452974_6 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 327.0
HFD2_k127_5452974_7 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 340.0
HFD2_k127_5452974_8 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001085 305.0
HFD2_k127_5452974_9 PFAM UvrB UvrC protein K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000198 278.0
HFD2_k127_5465830_0 PFAM Conserved region in glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1261.0
HFD2_k127_5465830_1 benzoyl-CoA reductase K04113 - 1.3.7.8 1.389e-198 646.0
HFD2_k127_5465830_10 Endonuclease exonuclease phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002726 287.0
HFD2_k127_5465830_11 PFAM DAHP synthetase I K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000004536 265.0
HFD2_k127_5465830_12 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000000000000000000000000000298 203.0
HFD2_k127_5465830_13 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000001089 219.0
HFD2_k127_5465830_14 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000001068 192.0
HFD2_k127_5465830_15 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.0000000000000000000000000000000000000003687 149.0
HFD2_k127_5465830_16 Peptidase family M28 - - - 0.000000000000000000000000000000000001382 162.0
HFD2_k127_5465830_17 ASPIC and UnbV - - - 0.00000000000000000000000000000000004283 158.0
HFD2_k127_5465830_18 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000005075 141.0
HFD2_k127_5465830_19 Subtilase family - - - 0.0000000000000000000000000000005894 143.0
HFD2_k127_5465830_2 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007561 497.0
HFD2_k127_5465830_20 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000001232 121.0
HFD2_k127_5465830_21 Peptidase family M1 domain K01256 - 3.4.11.2 0.00000000000000000003507 106.0
HFD2_k127_5465830_22 Subtilase family - - - 0.0000000000000000004131 104.0
HFD2_k127_5465830_23 - - - - 0.000000000000000001319 87.0
HFD2_k127_5465830_24 Zinc metalloprotease (Elastase) - - - 0.0000000000001718 85.0
HFD2_k127_5465830_25 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000009782 75.0
HFD2_k127_5465830_26 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000002085 69.0
HFD2_k127_5465830_27 transcriptional regulator - - - 0.000000003186 68.0
HFD2_k127_5465830_28 - - - - 0.000000009908 63.0
HFD2_k127_5465830_3 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 461.0
HFD2_k127_5465830_30 Type II secretion system (T2SS), protein F K12510 - - 0.000005996 60.0
HFD2_k127_5465830_31 protein import K01179 - 3.2.1.4 0.00004163 55.0
HFD2_k127_5465830_4 BadF/BadG/BcrA/BcrD ATPase family K04114 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 472.0
HFD2_k127_5465830_5 synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 451.0
HFD2_k127_5465830_6 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 429.0
HFD2_k127_5465830_7 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 445.0
HFD2_k127_5465830_8 Zinc-binding dehydrogenase K07538 - 1.1.1.368 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 373.0
HFD2_k127_5465830_9 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 306.0
HFD2_k127_5467820_0 transcription factor binding - - - 0.000000007812 67.0
HFD2_k127_5467820_1 Two component transcriptional regulator, winged helix family K07657 - - 0.00003749 51.0
HFD2_k127_5492756_0 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 513.0
HFD2_k127_5492756_1 arylamine N-acetyltransferase activity K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000000000000000003982 237.0
HFD2_k127_5492756_10 Phage integrase family - - - 0.0007365 43.0
HFD2_k127_5492756_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000002807 168.0
HFD2_k127_5492756_3 cellulose binding - - - 0.00000000000000000000000000000000000002443 167.0
HFD2_k127_5492756_4 Pkd domain containing protein K12567 - 2.7.11.1 0.0000000000000000000000000000000003875 153.0
HFD2_k127_5492756_5 Chemotaxis protein CheY K02479 - - 0.00000000000001717 81.0
HFD2_k127_5492756_6 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000003517 76.0
HFD2_k127_5492756_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000004112 77.0
HFD2_k127_5492756_8 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K01179 - 3.2.1.4 0.0000002537 65.0
HFD2_k127_5504276_0 - - - - 1.893e-276 883.0
HFD2_k127_5504276_1 Sugar ABC transporter permease K10109,K15770,K15771 - - 3.987e-201 646.0
HFD2_k127_5504276_10 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.000000000000000000000000000000000000000000000000000000000000000000007151 252.0
HFD2_k127_5504276_11 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000001578 168.0
HFD2_k127_5504276_12 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.00000000000000000000000000000002212 145.0
HFD2_k127_5504276_13 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.0000000000000000000001842 111.0
HFD2_k127_5504276_14 - - - - 0.0003959 49.0
HFD2_k127_5504276_2 Alpha-amylase domain K01176 - 3.2.1.1 2.248e-200 637.0
HFD2_k127_5504276_3 Alpha-amylase domain K01176 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 614.0
HFD2_k127_5504276_4 Bacterial extracellular solute-binding protein K10108,K15770 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 591.0
HFD2_k127_5504276_5 Belongs to the ABC transporter superfamily K05816,K10111,K10112 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 526.0
HFD2_k127_5504276_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 463.0
HFD2_k127_5504276_7 Binding-protein-dependent transport system inner membrane component K10110,K15772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 463.0
HFD2_k127_5504276_8 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006052 428.0
HFD2_k127_5504276_9 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 367.0
HFD2_k127_55121_0 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000000000000000000000000000001201 216.0
HFD2_k127_55121_1 amino acid activation for nonribosomal peptide biosynthetic process K05889 - 1.1.2.6 0.000000000000000003216 100.0
HFD2_k127_5535614_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 535.0
HFD2_k127_5535614_1 coenzyme binding K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 449.0
HFD2_k127_5535614_10 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000005483 147.0
HFD2_k127_5535614_11 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000005537 119.0
HFD2_k127_5535614_12 PHP domain protein - - - 0.000000000000000006005 96.0
HFD2_k127_5535614_2 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 341.0
HFD2_k127_5535614_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 292.0
HFD2_k127_5535614_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001496 273.0
HFD2_k127_5535614_5 MafB19-like deaminase K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000001272 247.0
HFD2_k127_5535614_6 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000000004329 228.0
HFD2_k127_5535614_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000006134 158.0
HFD2_k127_5535614_8 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000211 156.0
HFD2_k127_5535614_9 LexA-binding, inner membrane-associated putative hydrolase - - - 0.00000000000000000000000000000000000000695 152.0
HFD2_k127_5539226_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.543e-307 971.0
HFD2_k127_5539226_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 516.0
HFD2_k127_5539226_10 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000004694 236.0
HFD2_k127_5539226_11 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000004368 233.0
HFD2_k127_5539226_12 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000008348 228.0
HFD2_k127_5539226_13 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000005061 218.0
HFD2_k127_5539226_14 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000002028 212.0
HFD2_k127_5539226_15 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000005285 210.0
HFD2_k127_5539226_16 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000001636 207.0
HFD2_k127_5539226_17 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000346 193.0
HFD2_k127_5539226_18 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000003199 181.0
HFD2_k127_5539226_19 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000000000000001921 189.0
HFD2_k127_5539226_2 Histidine ammonia-lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 515.0
HFD2_k127_5539226_20 PFAM EAL domain protein - - - 0.0000000000000000000000000000000000000000004026 179.0
HFD2_k127_5539226_21 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000001481 166.0
HFD2_k127_5539226_22 OsmC-like protein - - - 0.000000000000000000000000000000000000001578 159.0
HFD2_k127_5539226_23 diguanylate cyclase - - - 0.000000000000000000000000000000000009347 153.0
HFD2_k127_5539226_24 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000006433 146.0
HFD2_k127_5539226_25 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000001197 127.0
HFD2_k127_5539226_26 beta-N-acetylglucosaminidase K01197 - 3.2.1.35 0.0000000000000000000000007567 119.0
HFD2_k127_5539226_27 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000004063 121.0
HFD2_k127_5539226_28 response regulator, receiver - - - 0.00000000000000000000007985 112.0
HFD2_k127_5539226_29 Rossmann-like domain - - - 0.000000000000000006218 98.0
HFD2_k127_5539226_3 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 485.0
HFD2_k127_5539226_30 cheY-homologous receiver domain - - - 0.000000000000000008321 98.0
HFD2_k127_5539226_31 response regulator - - - 0.0000000000000006154 87.0
HFD2_k127_5539226_32 - - - - 0.0000000000009798 74.0
HFD2_k127_5539226_34 peptidase U61 K01297 - 3.4.17.13 0.00003916 48.0
HFD2_k127_5539226_36 Sulfotransferase - - - 0.0007508 51.0
HFD2_k127_5539226_4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 414.0
HFD2_k127_5539226_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005497 338.0
HFD2_k127_5539226_6 Aminotransferase, class V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 307.0
HFD2_k127_5539226_7 Inositol monophosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 292.0
HFD2_k127_5539226_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003291 287.0
HFD2_k127_5539226_9 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000002151 248.0
HFD2_k127_5544297_0 Flavin containing amine oxidoreductase - - - 6.18e-215 702.0
HFD2_k127_5544297_1 epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 325.0
HFD2_k127_5544297_2 Protein of unknown function (DUF2723) - - - 0.000000000000000000000000000006009 136.0
HFD2_k127_5544297_3 polysaccharide biosynthetic process - - - 0.000000000000000000000000001779 128.0
HFD2_k127_5544297_4 Methyltransferase domain - - - 0.0000000000002602 79.0
HFD2_k127_5544297_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0001584 55.0
HFD2_k127_5559402_0 Heat shock 70 kDa protein K04043 - - 5.878e-236 745.0
HFD2_k127_5559402_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 499.0
HFD2_k127_5559402_10 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000104 217.0
HFD2_k127_5559402_11 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000004359 181.0
HFD2_k127_5559402_12 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000008083 157.0
HFD2_k127_5559402_13 diguanylate cyclase - - - 0.0000000000000000000000000000000000222 148.0
HFD2_k127_5559402_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.000000000000000000000000000000001616 148.0
HFD2_k127_5559402_15 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000009484 143.0
HFD2_k127_5559402_16 Biopolymer transport protein K03559,K03560 - - 0.0000000000000000000000002067 110.0
HFD2_k127_5559402_17 TIGRFAM TonB K03832 - - 0.00000224 58.0
HFD2_k127_5559402_18 PFAM Sporulation domain protein - - - 0.00000302 56.0
HFD2_k127_5559402_2 DnaJ central domain K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 389.0
HFD2_k127_5559402_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 376.0
HFD2_k127_5559402_4 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 332.0
HFD2_k127_5559402_5 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 352.0
HFD2_k127_5559402_6 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 312.0
HFD2_k127_5559402_7 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000785 308.0
HFD2_k127_5559402_8 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001424 290.0
HFD2_k127_5559402_9 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003902 282.0
HFD2_k127_5587912_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 3.056e-221 726.0
HFD2_k127_5587912_1 SMART PDZ DHR GLGF domain protein - - - 1.783e-196 631.0
HFD2_k127_5587912_10 Periplasmic sensor domain - - - 0.00006467 57.0
HFD2_k127_5587912_11 Matrixin - - - 0.0004221 50.0
HFD2_k127_5587912_2 Response regulator receiver modulated diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 614.0
HFD2_k127_5587912_3 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006953 591.0
HFD2_k127_5587912_4 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 465.0
HFD2_k127_5587912_5 Formiminotransferase-cyclodeaminase K00603,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 449.0
HFD2_k127_5587912_6 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000008026 214.0
HFD2_k127_5587912_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000004253 157.0
HFD2_k127_5587912_8 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000004282 72.0
HFD2_k127_5587912_9 energy transducer activity K02487,K03832,K06596 - - 0.00000004684 66.0
HFD2_k127_5626914_0 PFAM glycoside hydrolase family 39 K01198 - 3.2.1.37 0.000000000000000000009613 109.0
HFD2_k127_5626914_1 RNA polymerase sigma factor K03088 - - 0.000000000000000001933 93.0
HFD2_k127_5626914_2 Putative metal-binding motif - - - 0.00000000000000299 91.0
HFD2_k127_5626914_3 Fibrinogen-related domains (FReDs) - - - 0.00000002039 68.0
HFD2_k127_5626914_4 protein conserved in bacteria K09930 - - 0.0000168 47.0
HFD2_k127_5626914_5 Protein of unknown function (DUF1109) - - - 0.0007192 51.0
HFD2_k127_5704996_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1353.0
HFD2_k127_5704996_1 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 472.0
HFD2_k127_5704996_10 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000000000000000000000001143 152.0
HFD2_k127_5704996_11 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000002587 140.0
HFD2_k127_5704996_12 - - - - 0.0000000000000000000000000000000241 145.0
HFD2_k127_5704996_13 DoxX-like family - - - 0.0000000000000000000000000000004256 132.0
HFD2_k127_5704996_14 - - - - 0.000000000000000000000000000002076 126.0
HFD2_k127_5704996_15 - - - - 0.0000000000000007972 87.0
HFD2_k127_5704996_16 Domain of unknown function (DUF4115) K15539 - - 0.000000000000001326 88.0
HFD2_k127_5704996_17 outer membrane efflux protein - - - 0.0000000000002346 76.0
HFD2_k127_5704996_18 Tetratricopeptide repeat - - - 0.00000000004608 76.0
HFD2_k127_5704996_19 Cna B domain protein - - - 0.0000001614 64.0
HFD2_k127_5704996_2 epoxide hydrolase K01253 - 3.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 415.0
HFD2_k127_5704996_20 methyltransferase - - - 0.00005015 54.0
HFD2_k127_5704996_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 346.0
HFD2_k127_5704996_4 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001548 301.0
HFD2_k127_5704996_5 MgtE intracellular - - - 0.000000000000000000000000000000000000000000000000000000000000000000001403 254.0
HFD2_k127_5704996_6 iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000000000000000005487 228.0
HFD2_k127_5704996_7 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000006275 211.0
HFD2_k127_5704996_8 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000002571 205.0
HFD2_k127_5704996_9 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000002595 184.0
HFD2_k127_5817323_0 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 2.084e-263 818.0
HFD2_k127_5817323_1 Peptidase family M13 K01415,K07386 - 3.4.24.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 612.0
HFD2_k127_5817323_10 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 349.0
HFD2_k127_5817323_11 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004605 354.0
HFD2_k127_5817323_12 PFAM Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 362.0
HFD2_k127_5817323_13 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 340.0
HFD2_k127_5817323_14 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 299.0
HFD2_k127_5817323_15 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002986 275.0
HFD2_k127_5817323_16 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000174 291.0
HFD2_k127_5817323_17 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000001935 263.0
HFD2_k127_5817323_18 imidazolonepropionase activity K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000006697 259.0
HFD2_k127_5817323_19 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.000000000000000000000000000000000000000000000000001151 206.0
HFD2_k127_5817323_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 533.0
HFD2_k127_5817323_20 SUF system FeS assembly protein K04488 - - 0.000000000000000000000000000000000000000000005184 188.0
HFD2_k127_5817323_21 DoxX K15977 - - 0.000000000000000000000000000000000000000001819 165.0
HFD2_k127_5817323_22 MarR family transcriptional K15973 - - 0.00000000000000000000000000000000000000159 152.0
HFD2_k127_5817323_23 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 K03775 - 5.2.1.8 0.000000000000000000000000000000000000005621 167.0
HFD2_k127_5817323_24 Haemolysin-type calcium-binding repeat (2 copies) K03641,K11005 - - 0.000000000000000000000000000000000000519 160.0
HFD2_k127_5817323_25 2 iron, 2 sulfur cluster binding - - - 0.0000000000000000000000000000000000008841 147.0
HFD2_k127_5817323_26 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000003095 141.0
HFD2_k127_5817323_27 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.0000000000000000000000000000009406 132.0
HFD2_k127_5817323_28 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000000000316 137.0
HFD2_k127_5817323_29 RNA-DNA hybrid ribonuclease activity K03470,K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000003368 114.0
HFD2_k127_5817323_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 518.0
HFD2_k127_5817323_30 MatE - - - 0.00000000000006692 86.0
HFD2_k127_5817323_31 RDD family - - - 0.00000000000183 75.0
HFD2_k127_5817323_32 - - - - 0.00000000001004 78.0
HFD2_k127_5817323_33 Protein of unknown function (DUF4197) - - - 0.0000000003752 66.0
HFD2_k127_5817323_34 serine-type endopeptidase activity - - - 0.0000002542 64.0
HFD2_k127_5817323_4 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 544.0
HFD2_k127_5817323_5 oligopeptide transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009145 505.0
HFD2_k127_5817323_6 Nitronate monooxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 452.0
HFD2_k127_5817323_7 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 435.0
HFD2_k127_5817323_8 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 402.0
HFD2_k127_5817323_9 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 403.0
HFD2_k127_5833775_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1247.0
HFD2_k127_5833775_1 Angiotensin-converting enzyme K01283 - 3.4.15.1 4.112e-202 649.0
HFD2_k127_5833775_10 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000006538 164.0
HFD2_k127_5833775_11 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000002677 151.0
HFD2_k127_5833775_12 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000000000000000000000004145 141.0
HFD2_k127_5833775_13 nuclease activity - - - 0.0000000000000000000000000000000001371 138.0
HFD2_k127_5833775_14 Polymer-forming cytoskeletal - - - 0.000000000000000000000000003533 115.0
HFD2_k127_5833775_15 Peptidase M56 - - - 0.0000000000000000000000003053 122.0
HFD2_k127_5833775_16 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000001463 120.0
HFD2_k127_5833775_17 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000004638 110.0
HFD2_k127_5833775_18 IMP dehydrogenase activity K04767,K07182 - - 0.00000000000000000005586 97.0
HFD2_k127_5833775_19 Rhodanese Homology Domain - - - 0.0000000000000000001018 99.0
HFD2_k127_5833775_2 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 603.0
HFD2_k127_5833775_20 Protein of unknown function (DUF2723) - - - 0.0000000000000000009688 102.0
HFD2_k127_5833775_21 Methylamine utilisation protein MauE - - - 0.0000000000000005126 92.0
HFD2_k127_5833775_22 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000006703 78.0
HFD2_k127_5833775_23 Archease protein family (MTH1598/TM1083) - - - 0.00000000000002548 87.0
HFD2_k127_5833775_24 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000001458 85.0
HFD2_k127_5833775_25 Belongs to the 5'-nucleotidase family K01119 - 3.1.3.6,3.1.4.16 0.000000000002353 77.0
HFD2_k127_5833775_26 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000009256 63.0
HFD2_k127_5833775_27 Domain of unknown function (DUF4340) - - - 0.0000009792 61.0
HFD2_k127_5833775_28 uroporphyrinogen-III synthase activity K01719,K01749,K02496,K13542,K13543 GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.000002522 55.0
HFD2_k127_5833775_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 549.0
HFD2_k127_5833775_30 methyltransferase - - - 0.00008313 52.0
HFD2_k127_5833775_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 430.0
HFD2_k127_5833775_5 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 385.0
HFD2_k127_5833775_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 302.0
HFD2_k127_5833775_7 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001633 266.0
HFD2_k127_5833775_8 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000001759 162.0
HFD2_k127_5833775_9 ABC-type uncharacterized transport system K01992 - - 0.00000000000000000000000000000000000000001515 175.0
HFD2_k127_5858926_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 445.0
HFD2_k127_5858926_1 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 317.0
HFD2_k127_5858926_10 Subtilase family - - - 0.00000000000001972 90.0
HFD2_k127_5858926_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000005269 80.0
HFD2_k127_5858926_2 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 324.0
HFD2_k127_5858926_3 PFAM ExsB family protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000008457 233.0
HFD2_k127_5858926_4 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000002432 205.0
HFD2_k127_5858926_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000001236 208.0
HFD2_k127_5858926_6 RuvA, C-terminal domain K03550 - 3.6.4.12 0.000000000000000000000000000000000000000232 158.0
HFD2_k127_5858926_7 COG NOG14600 non supervised orthologous group - - - 0.000000000000000000000000000000000000000495 149.0
HFD2_k127_5858926_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000001567 122.0
HFD2_k127_5858926_9 Two component regulator propeller - - - 0.00000000000000001228 91.0
HFD2_k127_5896630_0 FAD linked oxidase domain protein - - - 0.0 1788.0
HFD2_k127_5896630_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 2.668e-304 943.0
HFD2_k127_5896630_2 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 2.159e-206 665.0
HFD2_k127_5896630_3 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 341.0
HFD2_k127_5896630_4 Transcription factor zinc-finger K09981 - - 0.0000000000000000000000000000000000000000000000000000001283 205.0
HFD2_k127_5896630_5 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000008052 187.0
HFD2_k127_5896630_6 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000001843 175.0
HFD2_k127_5896630_7 Ferredoxin K02230 - 6.6.1.2 0.0000000000000000000000001922 109.0
HFD2_k127_5898227_0 ABC transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 604.0
HFD2_k127_5898227_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009241 448.0
HFD2_k127_5898227_10 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000003394 165.0
HFD2_k127_5898227_11 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000001471 164.0
HFD2_k127_5898227_12 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000002201 156.0
HFD2_k127_5898227_13 CoA binding domain K06929 - - 0.00000000000000000008651 94.0
HFD2_k127_5898227_15 Thioredoxin-like - - - 0.000001464 51.0
HFD2_k127_5898227_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 382.0
HFD2_k127_5898227_3 Spermidine synthase K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 365.0
HFD2_k127_5898227_4 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 347.0
HFD2_k127_5898227_5 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 327.0
HFD2_k127_5898227_6 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000003067 251.0
HFD2_k127_5898227_7 ATPase associated with various cellular activities, AAA_5 K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007836 240.0
HFD2_k127_5898227_8 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000001941 244.0
HFD2_k127_5898227_9 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000001536 219.0
HFD2_k127_5965653_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 8.69e-254 800.0
HFD2_k127_5965653_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 380.0
HFD2_k127_5965653_2 PFAM molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001021 302.0
HFD2_k127_5965653_3 2Fe-2S -binding K13483 - - 0.0000000000000000000000000000000000000000000000000000005773 203.0
HFD2_k127_5965653_4 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000007217 177.0
HFD2_k127_5965653_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000001077 173.0
HFD2_k127_5965653_6 B3/4 domain - - - 0.0000000000000000000000000000000000003374 146.0
HFD2_k127_5965653_7 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000003744 158.0
HFD2_k127_5965653_8 - - - - 0.000000000000000005944 97.0
HFD2_k127_6162067_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 437.0
HFD2_k127_6162067_1 Protein kinase domain K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000002586 250.0
HFD2_k127_6162067_2 - - - - 0.000000000000000000000001356 119.0
HFD2_k127_6162067_3 histone H2A K63-linked ubiquitination K02283 - - 0.0000000000005548 78.0
HFD2_k127_6163257_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 2.118e-243 767.0
HFD2_k127_6163257_1 oligopeptide transporter, OPT family - - - 1.089e-195 632.0
HFD2_k127_6163257_10 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 344.0
HFD2_k127_6163257_11 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 344.0
HFD2_k127_6163257_12 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 331.0
HFD2_k127_6163257_13 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 326.0
HFD2_k127_6163257_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 339.0
HFD2_k127_6163257_15 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000002426 265.0
HFD2_k127_6163257_16 Glutamate--cysteine ligase K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000008171 264.0
HFD2_k127_6163257_17 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000008977 270.0
HFD2_k127_6163257_18 Family 5 K02035,K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001997 265.0
HFD2_k127_6163257_19 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000004918 232.0
HFD2_k127_6163257_2 Acyclic terpene utilisation family protein AtuA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 576.0
HFD2_k127_6163257_20 ABC transporter K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000008134 237.0
HFD2_k127_6163257_21 molybdate ABC transporter, permease protein K02017,K02018 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000124 221.0
HFD2_k127_6163257_22 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000531 231.0
HFD2_k127_6163257_23 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000003762 207.0
HFD2_k127_6163257_24 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000006821 211.0
HFD2_k127_6163257_25 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000006763 189.0
HFD2_k127_6163257_26 Phosphodiester glycosidase - - - 0.00000000000000000000000000000000000000001623 168.0
HFD2_k127_6163257_27 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000002336 176.0
HFD2_k127_6163257_28 - - - - 0.00000000000000000000000000004359 134.0
HFD2_k127_6163257_29 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 0.0000000000000000000000000004044 134.0
HFD2_k127_6163257_3 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 511.0
HFD2_k127_6163257_30 Polysaccharide deacetylase - - - 0.0000000000000000000000001117 124.0
HFD2_k127_6163257_31 PFAM HD domain - - - 0.0000000000000000000000009564 122.0
HFD2_k127_6163257_32 - - - - 0.000000000000000000000001104 109.0
HFD2_k127_6163257_33 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000004045 106.0
HFD2_k127_6163257_34 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000003408 111.0
HFD2_k127_6163257_35 Domain of unknown function (DUF4440) - - - 0.000000000000002653 91.0
HFD2_k127_6163257_36 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.000000000003839 76.0
HFD2_k127_6163257_37 - - - - 0.00002511 55.0
HFD2_k127_6163257_4 Proprotein convertase P-domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 535.0
HFD2_k127_6163257_5 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 482.0
HFD2_k127_6163257_6 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 461.0
HFD2_k127_6163257_7 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 444.0
HFD2_k127_6163257_8 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 426.0
HFD2_k127_6163257_9 Penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 351.0
HFD2_k127_6197685_0 TIGRFAM type VI secretion ATPase, ClpV1 family K11907 - - 0.0 1440.0
HFD2_k127_6197685_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1439.0
HFD2_k127_6197685_10 Involved in the tonB-independent uptake of proteins K03641 - - 1.012e-200 650.0
HFD2_k127_6197685_100 general secretion pathway protein K02456 - - 0.0000002903 60.0
HFD2_k127_6197685_101 Uncharacterized protein conserved in bacteria (DUF2094) K11890,K11910 - - 0.0000002977 62.0
HFD2_k127_6197685_102 - - - - 0.0000007656 60.0
HFD2_k127_6197685_103 STAS domain K04749 - - 0.000001346 56.0
HFD2_k127_6197685_104 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000002612 61.0
HFD2_k127_6197685_105 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000005944 57.0
HFD2_k127_6197685_106 COG3209 Rhs family protein - - - 0.000008434 58.0
HFD2_k127_6197685_107 SnoaL-like polyketide cyclase K07255 - - 0.00003869 55.0
HFD2_k127_6197685_108 - - - - 0.0004376 53.0
HFD2_k127_6197685_109 - - - - 0.0005007 53.0
HFD2_k127_6197685_11 amino acid carrier protein K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 614.0
HFD2_k127_6197685_12 nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006443 554.0
HFD2_k127_6197685_13 AlkA N-terminal domain K13529 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 535.0
HFD2_k127_6197685_14 Gp5 C-terminal repeat (3 copies) K11904 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 554.0
HFD2_k127_6197685_15 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 518.0
HFD2_k127_6197685_16 PFAM Pyridoxal-dependent decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 498.0
HFD2_k127_6197685_17 Peptidase M64 N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 498.0
HFD2_k127_6197685_18 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008766 491.0
HFD2_k127_6197685_19 alcohol dehydrogenase K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 446.0
HFD2_k127_6197685_2 cellulose binding - - - 0.0 1326.0
HFD2_k127_6197685_20 Threonine aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008904 412.0
HFD2_k127_6197685_21 SMART Tetratricopeptide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 415.0
HFD2_k127_6197685_22 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006289 380.0
HFD2_k127_6197685_23 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 380.0
HFD2_k127_6197685_24 6 heme-binding sites - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 349.0
HFD2_k127_6197685_25 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 350.0
HFD2_k127_6197685_26 ImpE protein K11898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 339.0
HFD2_k127_6197685_27 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 336.0
HFD2_k127_6197685_28 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 325.0
HFD2_k127_6197685_29 Zn-dependent protease contains TPR repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 337.0
HFD2_k127_6197685_3 Cytochrome C assembly protein - - - 1.269e-286 901.0
HFD2_k127_6197685_30 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 343.0
HFD2_k127_6197685_31 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 328.0
HFD2_k127_6197685_32 Pfam:T6SS_VasB K11895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 351.0
HFD2_k127_6197685_33 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 318.0
HFD2_k127_6197685_34 PFAM Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 322.0
HFD2_k127_6197685_35 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 317.0
HFD2_k127_6197685_36 PPIC-type PPIASE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 312.0
HFD2_k127_6197685_37 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 315.0
HFD2_k127_6197685_38 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001322 292.0
HFD2_k127_6197685_39 ImpA, N-terminal, type VI secretion system K11902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003523 286.0
HFD2_k127_6197685_4 Peptidase S46 - - - 7.411e-264 839.0
HFD2_k127_6197685_40 Putative esterase K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000521 276.0
HFD2_k127_6197685_41 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001079 268.0
HFD2_k127_6197685_42 Type VI secretion system, VipA, VC_A0107 or Hcp2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006086 270.0
HFD2_k127_6197685_43 molybdenum ion binding K07140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008565 250.0
HFD2_k127_6197685_44 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000182 234.0
HFD2_k127_6197685_45 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000009374 239.0
HFD2_k127_6197685_46 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001094 246.0
HFD2_k127_6197685_47 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000004418 250.0
HFD2_k127_6197685_48 Type VI secretion system effector, Hcp K06887,K11903 - - 0.00000000000000000000000000000000000000000000000000000000000000002264 227.0
HFD2_k127_6197685_49 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000006853 254.0
HFD2_k127_6197685_5 type VI secretion protein K11900 - - 7.257e-257 798.0
HFD2_k127_6197685_50 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001049 230.0
HFD2_k127_6197685_51 Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000001603 222.0
HFD2_k127_6197685_52 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000001688 223.0
HFD2_k127_6197685_53 Intracellular multiplication and human macrophage-killing K11891 - - 0.00000000000000000000000000000000000000000000000000000000001005 239.0
HFD2_k127_6197685_54 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000002728 214.0
HFD2_k127_6197685_55 Putative bacterial lipoprotein (DUF799) - - - 0.0000000000000000000000000000000000000000000000000000000001134 210.0
HFD2_k127_6197685_56 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000002375 221.0
HFD2_k127_6197685_57 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000003618 211.0
HFD2_k127_6197685_58 PASTA K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000000000000000000000000000000000000000000000000008427 218.0
HFD2_k127_6197685_59 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000002275 199.0
HFD2_k127_6197685_6 Aminotransferase class-V - - - 1.361e-241 764.0
HFD2_k127_6197685_60 Protein conserved in bacteria K09984 - - 0.0000000000000000000000000000000000000000000000000001728 190.0
HFD2_k127_6197685_61 phosphatase (DUF442) - - - 0.0000000000000000000000000000000000000000000000000002764 189.0
HFD2_k127_6197685_62 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000003335 184.0
HFD2_k127_6197685_63 metal cluster binding K06940 - - 0.000000000000000000000000000000000000000000000000005 191.0
HFD2_k127_6197685_64 serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000000000000000000008462 209.0
HFD2_k127_6197685_65 - - - - 0.0000000000000000000000000000000000000000000007252 181.0
HFD2_k127_6197685_66 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000001011 188.0
HFD2_k127_6197685_67 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000004901 170.0
HFD2_k127_6197685_69 TIGRFAM Type VI secretion system, lysozyme-related K11897 - - 0.00000000000000000000000000000000000000001105 160.0
HFD2_k127_6197685_7 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 4.742e-230 727.0
HFD2_k127_6197685_70 lyase activity - - - 0.000000000000000000000000000000000000000127 172.0
HFD2_k127_6197685_72 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000000000002089 154.0
HFD2_k127_6197685_73 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000002149 138.0
HFD2_k127_6197685_74 - - - - 0.00000000000000000000000000000000002235 150.0
HFD2_k127_6197685_75 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000006491 140.0
HFD2_k127_6197685_76 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000001207 133.0
HFD2_k127_6197685_77 Yqey-like protein K09117 - - 0.00000000000000000000000000000001996 140.0
HFD2_k127_6197685_78 type VI secretion protein K11893 - - 0.00000000000000000000000000000004307 143.0
HFD2_k127_6197685_79 - - - - 0.0000000000000000000000000000001602 134.0
HFD2_k127_6197685_8 Cytochrome c3 - - - 9.241e-226 718.0
HFD2_k127_6197685_80 - - - - 0.0000000000000000000000000000002125 144.0
HFD2_k127_6197685_81 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000002215 117.0
HFD2_k127_6197685_82 Protein of unknown function (DUF3396) - - - 0.00000000000000000000006681 109.0
HFD2_k127_6197685_83 self proteolysis - - - 0.000000000000000000002399 99.0
HFD2_k127_6197685_84 transposition, DNA-mediated K02342 - 2.7.7.7 0.000000000000000000002773 107.0
HFD2_k127_6197685_85 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000000000000002919 107.0
HFD2_k127_6197685_86 3-oxoacyl-[acyl-carrier-protein] synthase activity K00647 - 2.3.1.41 0.00000000000000000008487 103.0
HFD2_k127_6197685_88 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000001585 95.0
HFD2_k127_6197685_9 TIGRFAM type VI secretion protein, VC_A0110 family K11896 - - 1.244e-222 710.0
HFD2_k127_6197685_90 response regulator - - - 0.00000000000005601 79.0
HFD2_k127_6197685_91 regulation of DNA-templated transcription, elongation - - - 0.00000000001145 78.0
HFD2_k127_6197685_92 Type VI secretion system protein DotU K11892 - - 0.00000000002681 75.0
HFD2_k127_6197685_94 - - - - 0.000000001196 72.0
HFD2_k127_6197685_96 Integrin alpha (beta-propellor repeats). - - - 0.00000001181 68.0
HFD2_k127_6197685_97 Protein of unknown function (DUF533) - - - 0.00000007139 61.0
HFD2_k127_6197685_98 Rhomboid family K19225 - 3.4.21.105 0.00000009712 63.0
HFD2_k127_6258257_0 daunorubicin resistance ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 338.0
HFD2_k127_6258257_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 320.0
HFD2_k127_6258257_2 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004744 263.0
HFD2_k127_6258257_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000004555 263.0
HFD2_k127_6258257_4 Memo-like protein - - - 0.0000000000000000000000000000000000000000000000000000001807 215.0
HFD2_k127_6258257_5 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891,K15546 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000007285 201.0
HFD2_k127_6258257_6 enoyl-CoA hydratase K15513 - 4.1.2.44 0.0000000000000000000000000000000000000000000002341 183.0
HFD2_k127_6258257_7 AMMECR1 K09141 - - 0.0000000000000000000000000000004886 139.0
HFD2_k127_6307807_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 1588.0
HFD2_k127_6307807_1 1-deoxy-D-xylulose-5-phosphate synthase activity K01662 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030145,GO:0030975,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0040007,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 6.169e-200 643.0
HFD2_k127_6307807_10 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 372.0
HFD2_k127_6307807_11 PFAM Aldo keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006265 354.0
HFD2_k127_6307807_12 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 304.0
HFD2_k127_6307807_13 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000109 228.0
HFD2_k127_6307807_14 COG3119 Arylsulfatase A and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000001106 228.0
HFD2_k127_6307807_15 Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000005482 191.0
HFD2_k127_6307807_16 GHMP kinases C terminal K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000007558 203.0
HFD2_k127_6307807_17 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000774 165.0
HFD2_k127_6307807_18 NUDIX domain - - - 0.0000000000000000000000000000000000000000001789 168.0
HFD2_k127_6307807_19 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000002004 132.0
HFD2_k127_6307807_2 TIGRFAM nitrate reductase, beta subunit K00371 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 652.0
HFD2_k127_6307807_20 PFAM FecR protein - - - 0.0000000000000000000001326 112.0
HFD2_k127_6307807_21 Belongs to the UPF0200 family - - - 0.000000000000000000001276 108.0
HFD2_k127_6307807_22 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.000000000000000000001593 106.0
HFD2_k127_6307807_23 Protein of unknown function (DUF3467) - - - 0.00000000000000000008614 91.0
HFD2_k127_6307807_25 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.0000000000000009328 86.0
HFD2_k127_6307807_26 Tetratricopeptide repeat - - - 0.00000000000007207 86.0
HFD2_k127_6307807_27 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000001557 85.0
HFD2_k127_6307807_28 response regulator, receiver - - - 0.000000000001868 80.0
HFD2_k127_6307807_29 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000006338 68.0
HFD2_k127_6307807_3 Belongs to the aldehyde dehydrogenase family K00128,K09472 - 1.2.1.3,1.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 527.0
HFD2_k127_6307807_30 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000005566 63.0
HFD2_k127_6307807_32 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000003592 52.0
HFD2_k127_6307807_33 - - - - 0.00005724 46.0
HFD2_k127_6307807_34 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0006075 50.0
HFD2_k127_6307807_4 Major Facilitator Superfamily K02575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 524.0
HFD2_k127_6307807_5 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 509.0
HFD2_k127_6307807_6 Restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 514.0
HFD2_k127_6307807_7 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 423.0
HFD2_k127_6307807_8 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 422.0
HFD2_k127_6307807_9 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 377.0
HFD2_k127_6315338_0 amine dehydrogenase activity - - - 8.321e-240 775.0
HFD2_k127_6315338_1 Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 2.856e-224 734.0
HFD2_k127_6315338_10 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 410.0
HFD2_k127_6315338_11 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 372.0
HFD2_k127_6315338_12 PFAM thiamine pyrophosphate enzyme K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 366.0
HFD2_k127_6315338_13 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 348.0
HFD2_k127_6315338_14 Enoyl-(Acyl carrier protein) reductase K15734 - 1.1.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000001707 269.0
HFD2_k127_6315338_15 heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000005253 256.0
HFD2_k127_6315338_16 hydrolase of the alpha beta superfamily K07017 - - 0.0000000000000000000000000000000000000000000000000000000000000002219 253.0
HFD2_k127_6315338_17 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000001183 204.0
HFD2_k127_6315338_18 Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions K07322 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000002238 201.0
HFD2_k127_6315338_19 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000001984 217.0
HFD2_k127_6315338_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. K12266 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 580.0
HFD2_k127_6315338_20 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000004244 173.0
HFD2_k127_6315338_21 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000004458 146.0
HFD2_k127_6315338_22 Thioredoxin K03671 - - 0.0000000000000000000000000000000002116 138.0
HFD2_k127_6315338_23 - - - - 0.0000000000000000000000000000000003305 145.0
HFD2_k127_6315338_24 Protein tyrosine kinase - - - 0.0000000000000000000000000000000201 146.0
HFD2_k127_6315338_25 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000003984 128.0
HFD2_k127_6315338_26 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000009507 126.0
HFD2_k127_6315338_27 Protease prsW family - - - 0.00000000000000000000000000002844 136.0
HFD2_k127_6315338_28 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.000000000000000000000000004474 122.0
HFD2_k127_6315338_29 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000004333 104.0
HFD2_k127_6315338_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 522.0
HFD2_k127_6315338_30 Histidine kinase-like ATPase domain - - - 0.0000000000000001488 87.0
HFD2_k127_6315338_31 NAD(P)-binding Rossmann-like domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000001022 83.0
HFD2_k127_6315338_32 ferredoxin-NADP+ reductase activity - - - 0.000000000002045 71.0
HFD2_k127_6315338_33 PFAM regulatory protein, MarR - - - 0.00000001159 64.0
HFD2_k127_6315338_34 Malate synthase K01638 - 2.3.3.9 0.0000003567 61.0
HFD2_k127_6315338_35 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000003697 53.0
HFD2_k127_6315338_36 - - - - 0.0002646 50.0
HFD2_k127_6315338_4 DAHP synthetase I family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 513.0
HFD2_k127_6315338_5 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 505.0
HFD2_k127_6315338_6 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006827 521.0
HFD2_k127_6315338_7 COG1012 NAD-dependent aldehyde dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 512.0
HFD2_k127_6315338_8 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 431.0
HFD2_k127_6315338_9 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 416.0
HFD2_k127_6317505_0 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 0.0 1087.0
HFD2_k127_6317505_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 7.866e-311 966.0
HFD2_k127_6317505_10 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 567.0
HFD2_k127_6317505_11 Dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 495.0
HFD2_k127_6317505_12 ABC transporter K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009139 356.0
HFD2_k127_6317505_13 ABC-2 family transporter protein K19341 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 327.0
HFD2_k127_6317505_14 serine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 313.0
HFD2_k127_6317505_15 Zinc-uptake complex component A periplasmic K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009767 278.0
HFD2_k127_6317505_16 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000117 274.0
HFD2_k127_6317505_17 lipoprotein involved in nitrous oxide reduction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009825 260.0
HFD2_k127_6317505_18 ABC 3 transport family K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000002453 235.0
HFD2_k127_6317505_19 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000000000006917 187.0
HFD2_k127_6317505_2 OPT oligopeptide transporter protein - - - 5.696e-269 842.0
HFD2_k127_6317505_20 KDPG and KHG aldolase - - - 0.0000000000000000000000000000000000000000000000001885 183.0
HFD2_k127_6317505_21 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000008621 170.0
HFD2_k127_6317505_22 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000000000000005628 167.0
HFD2_k127_6317505_23 - - - - 0.00000000000000000000000000000000002024 140.0
HFD2_k127_6317505_24 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000000000000006257 144.0
HFD2_k127_6317505_27 RNA recognition motif - - - 0.000000000000000000000000001597 123.0
HFD2_k127_6317505_28 - - - - 0.0000000000000002649 83.0
HFD2_k127_6317505_29 Domain of unknown function (DUF4398) - - - 0.000004589 56.0
HFD2_k127_6317505_3 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 2.709e-231 756.0
HFD2_k127_6317505_4 Tricorn protease homolog K08676 - - 4.731e-223 731.0
HFD2_k127_6317505_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 5.85e-220 689.0
HFD2_k127_6317505_6 Cytochrome c - - - 3.362e-200 631.0
HFD2_k127_6317505_7 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 607.0
HFD2_k127_6317505_8 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006637 600.0
HFD2_k127_6317505_9 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 585.0
HFD2_k127_6380204_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 3.22e-241 762.0
HFD2_k127_6380204_1 DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 607.0
HFD2_k127_6380204_10 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000001251 202.0
HFD2_k127_6380204_11 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000001884 166.0
HFD2_k127_6380204_12 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000006184 143.0
HFD2_k127_6380204_13 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000003674 135.0
HFD2_k127_6380204_14 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000137 127.0
HFD2_k127_6380204_15 - - - - 0.000000000000000003367 87.0
HFD2_k127_6380204_16 Tetratricopeptide repeat - - - 0.00000002623 64.0
HFD2_k127_6380204_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 590.0
HFD2_k127_6380204_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 436.0
HFD2_k127_6380204_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 310.0
HFD2_k127_6380204_5 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008679 304.0
HFD2_k127_6380204_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 312.0
HFD2_k127_6380204_7 Deoxynucleoside kinase K15518 - 2.7.1.113 0.0000000000000000000000000000000000000000000000000000000000000003118 236.0
HFD2_k127_6380204_8 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000008187 217.0
HFD2_k127_6380204_9 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000009684 199.0
HFD2_k127_6454676_0 PFAM amidohydrolase - - - 1.011e-194 620.0
HFD2_k127_6454676_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 493.0
HFD2_k127_6454676_10 Di-iron-containing protein involved in the repair of iron-sulfur clusters - - - 0.00000000000000000000000000000000001466 141.0
HFD2_k127_6454676_2 Histidine biosynthesis trifunctional protein K14152 - 1.1.1.23,3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 459.0
HFD2_k127_6454676_3 SMART Tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 398.0
HFD2_k127_6454676_4 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 353.0
HFD2_k127_6454676_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 308.0
HFD2_k127_6454676_6 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000383 269.0
HFD2_k127_6454676_7 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000003144 226.0
HFD2_k127_6454676_8 Glutamine amidotransferase class-I K02501 - - 0.0000000000000000000000000000000000000000000005532 177.0
HFD2_k127_6454676_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000003401 160.0
HFD2_k127_6512860_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 550.0
HFD2_k127_6512860_1 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 351.0
HFD2_k127_6512860_10 Protein of unknown function (DUF1318) K09978 - - 0.000000000000000000000000001038 122.0
HFD2_k127_6512860_11 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000004247 122.0
HFD2_k127_6512860_12 light absorption - - - 0.0000001228 62.0
HFD2_k127_6512860_2 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001882 273.0
HFD2_k127_6512860_3 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005311 248.0
HFD2_k127_6512860_4 tRNA pseudouridine synthase K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000007576 234.0
HFD2_k127_6512860_5 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000977 210.0
HFD2_k127_6512860_6 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000009327 199.0
HFD2_k127_6512860_7 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000009834 184.0
HFD2_k127_6512860_8 - - - - 0.000000000000000000000000000000000000000000001094 171.0
HFD2_k127_6512860_9 Protein conserved in bacteria - - - 0.000000000000000000000000000000002481 151.0
HFD2_k127_6615923_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1243.0
HFD2_k127_6615923_1 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 587.0
HFD2_k127_6615923_10 Heparinase II/III N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 436.0
HFD2_k127_6615923_11 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 423.0
HFD2_k127_6615923_12 response regulator receiver K07714,K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009841 431.0
HFD2_k127_6615923_13 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 404.0
HFD2_k127_6615923_14 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 377.0
HFD2_k127_6615923_15 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 389.0
HFD2_k127_6615923_16 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 387.0
HFD2_k127_6615923_17 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 361.0
HFD2_k127_6615923_18 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 352.0
HFD2_k127_6615923_19 Thrombospondin type 3 repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 368.0
HFD2_k127_6615923_2 OB-fold nucleic acid binding domain K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 589.0
HFD2_k127_6615923_20 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 314.0
HFD2_k127_6615923_21 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 314.0
HFD2_k127_6615923_22 ABC transporter K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 303.0
HFD2_k127_6615923_23 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 295.0
HFD2_k127_6615923_24 Glucose dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 312.0
HFD2_k127_6615923_25 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001069 284.0
HFD2_k127_6615923_26 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000118 296.0
HFD2_k127_6615923_27 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000147 271.0
HFD2_k127_6615923_28 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000007278 284.0
HFD2_k127_6615923_29 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001824 282.0
HFD2_k127_6615923_3 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 575.0
HFD2_k127_6615923_30 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000002475 273.0
HFD2_k127_6615923_31 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002229 252.0
HFD2_k127_6615923_32 Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs K05544 - 1.3.1.89 0.000000000000000000000000000000000000000000000000000000000000000000002214 249.0
HFD2_k127_6615923_33 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000004304 259.0
HFD2_k127_6615923_34 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000009758 243.0
HFD2_k127_6615923_35 PFAM ATP-binding region, ATPase domain protein K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000001253 245.0
HFD2_k127_6615923_36 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000004297 240.0
HFD2_k127_6615923_37 PFAM response regulator receiver K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000003435 241.0
HFD2_k127_6615923_38 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000001492 231.0
HFD2_k127_6615923_39 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000005436 226.0
HFD2_k127_6615923_4 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 574.0
HFD2_k127_6615923_40 PFAM amidohydrolase K20810 - 3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000002006 228.0
HFD2_k127_6615923_41 deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000001559 228.0
HFD2_k127_6615923_42 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 0.00000000000000000000000000000000000000000000000000001252 196.0
HFD2_k127_6615923_43 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000006125 211.0
HFD2_k127_6615923_44 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000001509 199.0
HFD2_k127_6615923_45 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K15396 - 2.1.1.200 0.00000000000000000000000000000000000000006074 169.0
HFD2_k127_6615923_46 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000001726 168.0
HFD2_k127_6615923_47 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.000000000000000000000000000000000000004144 168.0
HFD2_k127_6615923_48 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000001769 155.0
HFD2_k127_6615923_49 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000004852 152.0
HFD2_k127_6615923_5 Phosphate transport system permease protein K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 568.0
HFD2_k127_6615923_50 TIGRFAM RNA polymerase sigma factor RpoS K03087 - - 0.00000000000000000000000000000002879 136.0
HFD2_k127_6615923_51 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000001709 138.0
HFD2_k127_6615923_52 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000269 139.0
HFD2_k127_6615923_53 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000003321 126.0
HFD2_k127_6615923_54 Phosphate-selective porin O and P - - - 0.0000000000000000000000000009219 128.0
HFD2_k127_6615923_55 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000002796 118.0
HFD2_k127_6615923_56 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000001451 119.0
HFD2_k127_6615923_57 Acetyltransferase (isoleucine patch - - - 0.0000000000000000000000007204 111.0
HFD2_k127_6615923_58 CHAD domain containing protein - - - 0.000000000000000000000003659 119.0
HFD2_k127_6615923_59 Exonuclease VII small subunit K03602 - 3.1.11.6 0.00000000000000000000301 109.0
HFD2_k127_6615923_6 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 480.0
HFD2_k127_6615923_60 lysyltransferase activity - - - 0.00000000000000000002043 104.0
HFD2_k127_6615923_61 Glutathione peroxidase - - - 0.0000000000000000001933 102.0
HFD2_k127_6615923_63 lysyltransferase activity - - - 0.000000000000000003704 96.0
HFD2_k127_6615923_64 Pfam:DUF303 K05970 - 3.1.1.53 0.00000000000000006087 96.0
HFD2_k127_6615923_66 PilZ domain - - - 0.0000000000000001794 83.0
HFD2_k127_6615923_69 Thrombospondin type 3 repeat - - - 0.0000000000002423 84.0
HFD2_k127_6615923_7 COG0226 ABC-type phosphate transport system periplasmic K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 458.0
HFD2_k127_6615923_70 amine dehydrogenase activity - - - 0.000000000001045 83.0
HFD2_k127_6615923_71 hydrolase family 81 - - - 0.000000003999 68.0
HFD2_k127_6615923_72 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000001421 63.0
HFD2_k127_6615923_73 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0003357 53.0
HFD2_k127_6615923_74 PFAM response regulator receiver K07657,K07658 - - 0.0003787 53.0
HFD2_k127_6615923_75 Serine aminopeptidase, S33 - - - 0.0004119 51.0
HFD2_k127_6615923_8 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 471.0
HFD2_k127_6615923_9 Glycosyltransferase Family 4 K13668 - 2.4.1.346 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006682 456.0
HFD2_k127_6687351_0 ATPase activity K02045 - 3.6.3.25 2.818e-203 650.0
HFD2_k127_6687351_1 L-aspartate oxidase K00278 - 1.4.3.16 2.744e-197 646.0
HFD2_k127_6687351_10 RNA pseudouridylate synthase K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002178 273.0
HFD2_k127_6687351_11 alanine dehydrogenase activity K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000008208 277.0
HFD2_k127_6687351_12 Pyruvate:ferredoxin oxidoreductase core domain II K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000005425 272.0
HFD2_k127_6687351_13 PFAM RES domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006539 244.0
HFD2_k127_6687351_14 Pyruvate ferredoxin/flavodoxin oxidoreductase K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000001084 198.0
HFD2_k127_6687351_15 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000000000000006367 146.0
HFD2_k127_6687351_16 Metallo-peptidase family M12B Reprolysin-like - - - 0.00000000000000000000000005556 125.0
HFD2_k127_6687351_17 Cytidylate kinase-like family - - - 0.000000000000000000000001395 113.0
HFD2_k127_6687351_18 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000002112 120.0
HFD2_k127_6687351_19 Cytochrome c K00406,K08906 - - 0.0000000000003926 77.0
HFD2_k127_6687351_2 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 542.0
HFD2_k127_6687351_20 Tetratricopeptide repeat - - - 0.0000000002211 72.0
HFD2_k127_6687351_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 507.0
HFD2_k127_6687351_4 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 514.0
HFD2_k127_6687351_5 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008842 467.0
HFD2_k127_6687351_6 Binding-protein-dependent transport system inner membrane component K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 371.0
HFD2_k127_6687351_7 sulfate transport system, permease K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 366.0
HFD2_k127_6687351_8 synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000011 287.0
HFD2_k127_6687351_9 Two component transcriptional regulator, winged helix family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004908 306.0
HFD2_k127_6842434_0 Protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 564.0
HFD2_k127_6842434_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 343.0
HFD2_k127_6842434_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 294.0
HFD2_k127_6842434_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 287.0
HFD2_k127_6842434_4 methyltransferase K00563,K10947 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008270,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0052912,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.187 0.00000000000000000000000000000000000000000000000000000000000000006541 233.0
HFD2_k127_6842434_5 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000003148 211.0
HFD2_k127_6842434_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000002103 187.0
HFD2_k127_6842434_7 Sporulation and spore germination - - - 0.0000000000000000003253 97.0
HFD2_k127_6842434_8 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00003306 53.0
HFD2_k127_6844014_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1014.0
HFD2_k127_6844014_1 FtsX-like permease family K02004 - - 2.672e-259 835.0
HFD2_k127_6844014_10 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001158 276.0
HFD2_k127_6844014_11 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000004429 220.0
HFD2_k127_6844014_12 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000000000000000000000006576 206.0
HFD2_k127_6844014_13 pyridoxal 5'-phosphate salvage K00020,K00275 - 1.1.1.31,1.4.3.5 0.0000000000000000000000000000000000000000000000000006436 192.0
HFD2_k127_6844014_14 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000002869 169.0
HFD2_k127_6844014_15 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000002853 180.0
HFD2_k127_6844014_16 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000006328 169.0
HFD2_k127_6844014_17 uridine kinase K00876 - 2.7.1.48 0.000000000000000000000000000000000000006874 167.0
HFD2_k127_6844014_18 PFAM Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000009604 120.0
HFD2_k127_6844014_19 - - - - 0.00000000000001212 78.0
HFD2_k127_6844014_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 4.374e-204 642.0
HFD2_k127_6844014_20 Protein of unknown function (DUF433) - - - 0.00000000000004125 76.0
HFD2_k127_6844014_21 - - - - 0.00000000000005071 79.0
HFD2_k127_6844014_23 Putative metal-binding motif - - - 0.00000000002428 78.0
HFD2_k127_6844014_24 Peptidase M16 inactive domain - - - 0.000008217 59.0
HFD2_k127_6844014_3 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 569.0
HFD2_k127_6844014_4 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 479.0
HFD2_k127_6844014_5 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 448.0
HFD2_k127_6844014_6 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000931 418.0
HFD2_k127_6844014_7 4Fe-4S ferredoxin iron-sulfur binding domain protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005669 367.0
HFD2_k127_6844014_8 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 310.0
HFD2_k127_6844014_9 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002046 279.0
HFD2_k127_6917284_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 321.0
HFD2_k127_6917284_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 299.0
HFD2_k127_6917284_2 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001014 294.0
HFD2_k127_6917284_3 Probable molybdopterin binding domain K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000007006 261.0
HFD2_k127_6917284_4 PFAM PHP domain protein K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000000001883 194.0
HFD2_k127_6917284_5 Riboflavin synthase K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000001931 156.0
HFD2_k127_6917284_6 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000206 131.0
HFD2_k127_6917284_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000002119 116.0
HFD2_k127_6917284_8 Tetratricopeptide TPR_2 repeat protein K12600 - - 0.000000000000000000000005589 117.0
HFD2_k127_6944391_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.11e-233 737.0
HFD2_k127_6944391_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009078 550.0
HFD2_k127_6944391_11 Belongs to the ClpA ClpB family K03696 - - 0.00000000000000000000000000000000000009099 162.0
HFD2_k127_6944391_12 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000007838 157.0
HFD2_k127_6944391_13 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000002262 141.0
HFD2_k127_6944391_14 - - - - 0.000000000000000000000000000002262 140.0
HFD2_k127_6944391_15 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000007654 112.0
HFD2_k127_6944391_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.0000000000001982 75.0
HFD2_k127_6944391_17 Belongs to the UPF0434 family K09791 - - 0.00000000003475 75.0
HFD2_k127_6944391_18 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.000000002605 70.0
HFD2_k127_6944391_19 TPR repeat - - - 0.000001101 58.0
HFD2_k127_6944391_2 Cleaves the N-terminal amino acid of tripeptides K01258 - 3.4.11.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 520.0
HFD2_k127_6944391_20 - - - - 0.000314 51.0
HFD2_k127_6944391_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00322 - 1.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 491.0
HFD2_k127_6944391_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009292 389.0
HFD2_k127_6944391_5 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 346.0
HFD2_k127_6944391_6 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 312.0
HFD2_k127_6944391_7 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000002832 223.0
HFD2_k127_6944391_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000002837 207.0
HFD2_k127_6944391_9 PFAM glycosyl transferase family 9 K02841 - - 0.000000000000000000000000000000000000000006727 168.0
HFD2_k127_7001404_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 391.0
HFD2_k127_7001404_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 406.0
HFD2_k127_7001404_10 Cytochrome c assembly protein - - - 0.000000000000000000000000151 119.0
HFD2_k127_7001404_11 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.0000000000005601 75.0
HFD2_k127_7001404_12 - - - - 0.00000000007519 67.0
HFD2_k127_7001404_13 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000003664 59.0
HFD2_k127_7001404_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 377.0
HFD2_k127_7001404_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 317.0
HFD2_k127_7001404_4 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000004175 273.0
HFD2_k127_7001404_5 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000001432 222.0
HFD2_k127_7001404_6 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000001175 206.0
HFD2_k127_7001404_7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000001258 190.0
HFD2_k127_7001404_8 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000001048 172.0
HFD2_k127_7001404_9 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.000000000000000000000000000000000000000009987 164.0
HFD2_k127_7028097_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 5.425e-255 833.0
HFD2_k127_7028097_1 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 332.0
HFD2_k127_7028097_2 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily K01002 - 2.7.8.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 339.0
HFD2_k127_7028097_3 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 297.0
HFD2_k127_7028097_4 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000004883 152.0
HFD2_k127_7028097_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000009182 100.0
HFD2_k127_7028097_6 Modulates RecA activity K03565 - - 0.00006702 52.0
HFD2_k127_7067093_0 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008785 287.0
HFD2_k127_7067093_1 Protein of unknown function (DUF3224) - - - 0.0000000000000000000000000000000000000000000000003638 188.0
HFD2_k127_7067093_2 Predicted membrane protein (DUF2127) - - - 0.00000000000000000000000000000000000000000000002846 172.0
HFD2_k127_7067093_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000009561 165.0
HFD2_k127_7067093_4 Predicted integral membrane protein (DUF2269) - - - 0.0000000000000000000001027 103.0
HFD2_k127_7096730_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.437e-205 651.0
HFD2_k127_7096730_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 604.0
HFD2_k127_7096730_10 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 0.000000000000000000000000000000000000007121 159.0
HFD2_k127_7096730_11 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000002606 162.0
HFD2_k127_7096730_12 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000003804 136.0
HFD2_k127_7096730_13 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000001041 117.0
HFD2_k127_7096730_14 translation initiation factor activity K03699 - - 0.000000000000000000005508 102.0
HFD2_k127_7096730_15 HNH endonuclease - - - 0.0000000000001597 72.0
HFD2_k127_7096730_16 NHL repeat containing protein - - - 0.000000000001127 79.0
HFD2_k127_7096730_17 Domain of unknown function (DUF4349) - - - 0.00000000001093 75.0
HFD2_k127_7096730_18 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000003552 71.0
HFD2_k127_7096730_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 622.0
HFD2_k127_7096730_20 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.0006114 53.0
HFD2_k127_7096730_3 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008439 442.0
HFD2_k127_7096730_4 TIGRFAM aminoacyl-histidine dipeptidase K01270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 433.0
HFD2_k127_7096730_5 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 342.0
HFD2_k127_7096730_6 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003458 278.0
HFD2_k127_7096730_7 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002726 265.0
HFD2_k127_7096730_8 metal-dependent phosphohydrolase HD - - - 0.000000000000000000000000000000000000000000000000000000000000000000002527 255.0
HFD2_k127_7096730_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000005939 171.0
HFD2_k127_7097231_0 PFAM DNA primase small subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 470.0
HFD2_k127_7097231_1 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001448 256.0
HFD2_k127_7147006_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1372.0
HFD2_k127_7147006_1 PFAM peptidase M1, membrane alanine aminopeptidase - - - 2e-323 1030.0
HFD2_k127_7147006_11 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 289.0
HFD2_k127_7147006_12 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 300.0
HFD2_k127_7147006_13 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000005475 278.0
HFD2_k127_7147006_14 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000069 270.0
HFD2_k127_7147006_15 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000003779 259.0
HFD2_k127_7147006_16 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000003112 251.0
HFD2_k127_7147006_17 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000001252 237.0
HFD2_k127_7147006_18 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000002947 245.0
HFD2_k127_7147006_19 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000007583 243.0
HFD2_k127_7147006_2 - - - - 1.892e-195 631.0
HFD2_k127_7147006_20 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000000000000000002143 247.0
HFD2_k127_7147006_21 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000003103 197.0
HFD2_k127_7147006_22 Methyltransferase type 11 K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000001149 173.0
HFD2_k127_7147006_23 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000002088 164.0
HFD2_k127_7147006_24 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000001484 173.0
HFD2_k127_7147006_25 - - - - 0.000000000000000000000000000000000001646 147.0
HFD2_k127_7147006_26 Chalcone isomerase-like - - - 0.00000000000000000000000000000000007198 141.0
HFD2_k127_7147006_27 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000001304 123.0
HFD2_k127_7147006_28 Transglutaminase-like superfamily - - - 0.0000000000000000000000001511 121.0
HFD2_k127_7147006_29 smart pdz dhr glgf K04691,K04771,K08070 GO:0008150,GO:0009266,GO:0009628,GO:0050896 1.3.1.74,3.4.21.107 0.00000000001144 75.0
HFD2_k127_7147006_3 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 507.0
HFD2_k127_7147006_4 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 436.0
HFD2_k127_7147006_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 383.0
HFD2_k127_7147006_6 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 360.0
HFD2_k127_7147006_7 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 349.0
HFD2_k127_7147006_8 PFAM Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 350.0
HFD2_k127_7147006_9 Amino acid kinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 322.0
HFD2_k127_7177463_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 549.0
HFD2_k127_7177463_1 regulation of microtubule-based process K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 434.0
HFD2_k127_7177463_2 Peptidase family M23 - - - 0.000000000000002539 91.0
HFD2_k127_7177463_3 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000001564 72.0
HFD2_k127_7187503_0 Polysaccharide biosynthesis protein K15912 - 4.2.1.135 0.00000000000000000000000000000000000007849 146.0
HFD2_k127_7187503_1 Sulfatase - - - 0.0000000000000000000000000000000000008061 162.0
HFD2_k127_7187503_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0009501 52.0
HFD2_k127_7200502_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.507e-299 946.0
HFD2_k127_7200502_1 PFAM Type II secretion system protein E K02652 - - 3.011e-220 715.0
HFD2_k127_7200502_10 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000001324 192.0
HFD2_k127_7200502_11 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000000001269 157.0
HFD2_k127_7200502_12 Domain of unknown function (DUF814) - - - 0.000000000000000000000000000000000107 152.0
HFD2_k127_7200502_13 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000004039 130.0
HFD2_k127_7200502_14 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000007735 130.0
HFD2_k127_7200502_15 Thrombospondin type 3 repeat - - - 0.000000000000000000000000000007045 136.0
HFD2_k127_7200502_16 general secretion pathway protein K02456 - - 0.00000000000000000000000000002213 124.0
HFD2_k127_7200502_17 Pilus assembly protein K02662 - - 0.0000000000000000000004502 108.0
HFD2_k127_7200502_18 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.0000000000000000002012 104.0
HFD2_k127_7200502_19 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000003346 96.0
HFD2_k127_7200502_2 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 578.0
HFD2_k127_7200502_20 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000004474 89.0
HFD2_k127_7200502_22 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.0000000000001719 77.0
HFD2_k127_7200502_23 general secretion pathway protein K02456,K02650 - - 0.000000001251 68.0
HFD2_k127_7200502_24 PKD domain - - - 0.000009226 58.0
HFD2_k127_7200502_25 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000541 51.0
HFD2_k127_7200502_26 PFAM Fimbrial assembly family protein K02663 - - 0.0006635 52.0
HFD2_k127_7200502_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 524.0
HFD2_k127_7200502_4 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 404.0
HFD2_k127_7200502_5 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 394.0
HFD2_k127_7200502_6 Type ii and iii secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 349.0
HFD2_k127_7200502_7 PFAM Type II secretion system F domain K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000778 287.0
HFD2_k127_7200502_8 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000005068 200.0
HFD2_k127_7200502_9 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000006382 202.0
HFD2_k127_7209425_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1632.0
HFD2_k127_7209425_1 Tricorn protease homolog - - - 0.0 1388.0
HFD2_k127_7209425_10 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 314.0
HFD2_k127_7209425_11 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008969 278.0
HFD2_k127_7209425_12 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003224 278.0
HFD2_k127_7209425_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000014 271.0
HFD2_k127_7209425_14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000002498 258.0
HFD2_k127_7209425_16 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005799 260.0
HFD2_k127_7209425_17 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000008065 249.0
HFD2_k127_7209425_18 PhoQ Sensor K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000001509 244.0
HFD2_k127_7209425_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000001413 244.0
HFD2_k127_7209425_2 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.129e-258 846.0
HFD2_k127_7209425_20 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000003363 231.0
HFD2_k127_7209425_21 metal cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000001261 222.0
HFD2_k127_7209425_22 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000007485 214.0
HFD2_k127_7209425_23 GAF domain - - - 0.0000000000000000000000000000000000000000000000000196 203.0
HFD2_k127_7209425_24 Ligand-binding protein K01999 - - 0.0000000000000000000000000000000000000000002787 173.0
HFD2_k127_7209425_25 Hfq protein - - - 0.00000000000000000000000000000000004925 139.0
HFD2_k127_7209425_26 Alkaline phosphatase synthesis transcriptional regulatory protein K07658 - - 0.00000000000000000000000000000000106 150.0
HFD2_k127_7209425_27 Universal stress protein family - - - 0.00000000000000000000000000000002736 145.0
HFD2_k127_7209425_28 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000005683 118.0
HFD2_k127_7209425_29 peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.00000000000000000000001063 117.0
HFD2_k127_7209425_3 DNA RNA helicase - - - 2.517e-245 784.0
HFD2_k127_7209425_30 AMP binding K06149 - - 0.00000000000000000000008196 108.0
HFD2_k127_7209425_31 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000008663 104.0
HFD2_k127_7209425_32 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07226 - - 0.000000000000000008229 89.0
HFD2_k127_7209425_33 AAA domain - - - 0.0000000000002884 82.0
HFD2_k127_7209425_34 Domain of unknown function (DUF4252) - - - 0.000000000008421 77.0
HFD2_k127_7209425_35 Putative zinc-finger - - - 0.000006431 57.0
HFD2_k127_7209425_36 Tetratricopeptide repeat - - - 0.0007098 51.0
HFD2_k127_7209425_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.791e-239 747.0
HFD2_k127_7209425_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 9.157e-197 621.0
HFD2_k127_7209425_6 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 514.0
HFD2_k127_7209425_7 response regulator K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009929 496.0
HFD2_k127_7209425_8 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 409.0
HFD2_k127_7209425_9 Histidine kinase K07641,K07711 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 383.0
HFD2_k127_7216742_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.245e-277 891.0
HFD2_k127_7216742_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 588.0
HFD2_k127_7216742_10 Ferrous iron transport protein B K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000004118 179.0
HFD2_k127_7216742_11 Tetratricopeptide repeat - - - 0.0000000000000000000006245 104.0
HFD2_k127_7216742_12 - - - - 0.00000000000000009465 89.0
HFD2_k127_7216742_13 Pfam Secreted repeat of - - - 0.0000000000004137 81.0
HFD2_k127_7216742_14 PFAM transposase IS116 IS110 IS902 family protein - - - 0.0000000000004198 72.0
HFD2_k127_7216742_16 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000172 63.0
HFD2_k127_7216742_17 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.000002433 60.0
HFD2_k127_7216742_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 553.0
HFD2_k127_7216742_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 558.0
HFD2_k127_7216742_4 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 374.0
HFD2_k127_7216742_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 310.0
HFD2_k127_7216742_6 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 315.0
HFD2_k127_7216742_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000153 232.0
HFD2_k127_7216742_9 - - - - 0.0000000000000000000000000000000000000000000000001076 196.0
HFD2_k127_7258244_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1463.0
HFD2_k127_7258244_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 4.363e-321 1005.0
HFD2_k127_7258244_10 L-threonylcarbamoyladenylate synthase K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 312.0
HFD2_k127_7258244_11 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007631 301.0
HFD2_k127_7258244_12 PFAM von Willebrand factor type A K01337 - 3.4.21.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000409 303.0
HFD2_k127_7258244_13 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006104 267.0
HFD2_k127_7258244_14 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000478 239.0
HFD2_k127_7258244_15 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000006383 242.0
HFD2_k127_7258244_16 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000007797 216.0
HFD2_k127_7258244_17 Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000008972 225.0
HFD2_k127_7258244_18 Endoribonuclease L-PSP K15067 - 3.5.99.5 0.00000000000000000000000000000000000000000000000000000001324 201.0
HFD2_k127_7258244_19 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000554 180.0
HFD2_k127_7258244_2 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 535.0
HFD2_k127_7258244_20 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000007318 161.0
HFD2_k127_7258244_21 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000001308 148.0
HFD2_k127_7258244_22 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000000000004927 125.0
HFD2_k127_7258244_23 - - - - 0.0000000000000000000001177 109.0
HFD2_k127_7258244_24 - - - - 0.000000000000000001331 97.0
HFD2_k127_7258244_25 PFAM ABC-2 type transporter K01992 - - 0.000000000000000008646 97.0
HFD2_k127_7258244_26 Peptidase C26 K01951 - 6.3.5.2 0.00000000000001411 87.0
HFD2_k127_7258244_27 Bacterial regulatory proteins, tetR family - - - 0.0000000001729 68.0
HFD2_k127_7258244_28 membrane K08988 - - 0.0000001354 61.0
HFD2_k127_7258244_29 Domain of unknown function (DUF4382) - - - 0.0001641 52.0
HFD2_k127_7258244_3 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 493.0
HFD2_k127_7258244_4 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 473.0
HFD2_k127_7258244_5 FAD binding domain K00486 - 1.14.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 450.0
HFD2_k127_7258244_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 423.0
HFD2_k127_7258244_7 RND efflux system, outer membrane lipoprotein K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 440.0
HFD2_k127_7258244_8 Tryptophan 2,3-dioxygenase K00453 - 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 366.0
HFD2_k127_7258244_9 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 345.0
HFD2_k127_728881_0 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002137 298.0
HFD2_k127_728881_1 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006778 274.0
HFD2_k127_728881_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007679 248.0
HFD2_k127_728881_3 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000282 162.0
HFD2_k127_728881_5 Predicted membrane protein (DUF2157) - - - 0.00000000000000000000000000000000112 137.0
HFD2_k127_728881_6 PFAM beta-lactamase domain protein K02238 - - 0.0000000000000000000000000005645 129.0
HFD2_k127_728881_7 Domain of unknown function (DUF4824) - - - 0.00000000000002121 86.0
HFD2_k127_728881_8 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - - 0.000004811 57.0
HFD2_k127_7376670_0 amino acid activation for nonribosomal peptide biosynthetic process K05889 - 1.1.2.6 0.00000000007041 76.0
HFD2_k127_7392752_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 514.0
HFD2_k127_7392752_1 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 498.0
HFD2_k127_7392752_10 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000002573 59.0
HFD2_k127_7392752_2 FecR protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 445.0
HFD2_k127_7392752_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 414.0
HFD2_k127_7392752_4 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 401.0
HFD2_k127_7392752_5 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 375.0
HFD2_k127_7392752_6 - - - - 0.00000000000000000000000000000000000000000000000005454 199.0
HFD2_k127_7392752_7 - - - - 0.0000000000000000000000000000000000000001041 170.0
HFD2_k127_7392752_8 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000005787 140.0
HFD2_k127_7392752_9 PFAM transposase IS4 family protein - - - 0.000000000000000000000000000000004692 134.0
HFD2_k127_7502591_1 CHAT domain - - - 0.0000001202 63.0
HFD2_k127_75619_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1083.0
HFD2_k127_75619_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.734e-288 901.0
HFD2_k127_75619_10 Methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 395.0
HFD2_k127_75619_11 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 392.0
HFD2_k127_75619_12 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 355.0
HFD2_k127_75619_13 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003288 283.0
HFD2_k127_75619_14 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001145 280.0
HFD2_k127_75619_15 Uncharacterized conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000268 258.0
HFD2_k127_75619_16 PFAM CBS domain containing protein K06189 - - 0.0000000000000000000000000000000000000000000000000000000004287 223.0
HFD2_k127_75619_17 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000007024 201.0
HFD2_k127_75619_18 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000000000000000000000000000000000185 151.0
HFD2_k127_75619_19 MMPL family K07003 - - 0.0000000000000000000000000001894 126.0
HFD2_k127_75619_2 PFAM carboxyl transferase K01615 - 4.1.1.70 1.824e-233 757.0
HFD2_k127_75619_20 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000004242 126.0
HFD2_k127_75619_21 ligase activity, forming carbon-carbon bonds K00627,K00645,K01572,K02160 - 2.3.1.12,2.3.1.39,4.1.1.3 0.0000000000000000000001528 106.0
HFD2_k127_75619_22 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000503 104.0
HFD2_k127_75619_23 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000002415 90.0
HFD2_k127_75619_24 Protein of unknown function (DUF1501) - - - 0.00000000000003399 87.0
HFD2_k127_75619_25 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000115 81.0
HFD2_k127_75619_26 endothelial cell-cell adhesion K04659 GO:0000902,GO:0001501,GO:0001503,GO:0001932,GO:0001934,GO:0001936,GO:0001938,GO:0001968,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002688,GO:0002690,GO:0003416,GO:0003417,GO:0003674,GO:0005102,GO:0005178,GO:0005488,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006928,GO:0006950,GO:0007155,GO:0007160,GO:0007275,GO:0007399,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008284,GO:0009653,GO:0009790,GO:0009887,GO:0009888,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0012505,GO:0014812,GO:0016043,GO:0016203,GO:0016477,GO:0016525,GO:0016528,GO:0016529,GO:0019220,GO:0019222,GO:0021700,GO:0022008,GO:0022603,GO:0022607,GO:0022610,GO:0030030,GO:0030054,GO:0030055,GO:0030154,GO:0030182,GO:0030334,GO:0030335,GO:0030855,GO:0031012,GO:0031175,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031589,GO:0031594,GO:0032101,GO:0032103,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032879,GO:0032989,GO:0032990,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0035989,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042127,GO:0042325,GO:0042327,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0043237,GO:0043931,GO:0043933,GO:0044085,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045202,GO:0045765,GO:0045937,GO:0046872,GO:0048265,GO:0048266,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048584,GO:0048589,GO:0048646,GO:0048666,GO:0048699,GO:0048705,GO:0048731,GO:0048799,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050730,GO:0050731,GO:0050789,GO:0050793,GO:0050794,GO:0050839,GO:0050840,GO:0050896,GO:0050920,GO:0050921,GO:0051093,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051216,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051272,GO:0051451,GO:0051674,GO:0051716,GO:0060231,GO:0060255,GO:0060343,GO:0060346,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060538,GO:0061053,GO:0061061,GO:0061383,GO:0061430,GO:0061448,GO:0062023,GO:0065003,GO:0065007,GO:0070161,GO:0070977,GO:0071603,GO:0071622,GO:0071624,GO:0071695,GO:0071840,GO:0080090,GO:0090022,GO:0090023,GO:0090136,GO:0097367,GO:0098609,GO:0098868,GO:0120036,GO:0120039,GO:1901342,GO:1901343,GO:1901681,GO:1902622,GO:1902624,GO:2000026,GO:2000145,GO:2000147,GO:2000181 - 0.000003366 57.0
HFD2_k127_75619_27 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.0000148 56.0
HFD2_k127_75619_3 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 620.0
HFD2_k127_75619_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 544.0
HFD2_k127_75619_5 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003392 460.0
HFD2_k127_75619_6 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 432.0
HFD2_k127_75619_7 PFAM glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 419.0
HFD2_k127_75619_8 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 414.0
HFD2_k127_75619_9 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 419.0
HFD2_k127_7639222_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000006515 236.0
HFD2_k127_7639222_1 IMG reference gene - - - 0.00000000000000000000000001625 123.0
HFD2_k127_7639222_2 IMG reference gene - - - 0.0001959 47.0
HFD2_k127_7641228_0 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 300.0
HFD2_k127_7641228_1 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001238 253.0
HFD2_k127_7641228_2 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001834 252.0
HFD2_k127_7641228_3 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000004245 179.0
HFD2_k127_7667164_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 9.48e-197 626.0
HFD2_k127_7667164_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 415.0
HFD2_k127_7667164_10 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000002451 178.0
HFD2_k127_7667164_11 S-layer homology domain - - - 0.0000000000000000000000000000000000000000000002382 182.0
HFD2_k127_7667164_12 ECF sigma factor - - - 0.00000000000000000000000000000000000000000009581 169.0
HFD2_k127_7667164_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.00000000000000000000000000000000000007222 148.0
HFD2_k127_7667164_15 SMART Integrin alpha beta-propellor repeat protein - - - 0.00000000000000000000000000001104 139.0
HFD2_k127_7667164_16 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.00000000000000000000000000007393 121.0
HFD2_k127_7667164_17 - - - - 0.000000000000000000000000001979 123.0
HFD2_k127_7667164_19 Transglycosylase associated protein - - - 0.0000000000000000005994 89.0
HFD2_k127_7667164_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 353.0
HFD2_k127_7667164_22 PFAM regulatory protein LuxR - - - 0.000000000002084 67.0
HFD2_k127_7667164_23 Periplasmic or secreted lipoprotein K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.000000000002296 74.0
HFD2_k127_7667164_24 - - - - 0.000000002894 70.0
HFD2_k127_7667164_25 Periplasmic component of the Tol biopolymer transport system - - - 0.000001283 62.0
HFD2_k127_7667164_26 phosphoric diester hydrolase activity - - - 0.000001432 60.0
HFD2_k127_7667164_27 response regulator K02483 GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0098771 - 0.00001351 53.0
HFD2_k127_7667164_28 HAF family - - - 0.0002373 53.0
HFD2_k127_7667164_3 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004762 271.0
HFD2_k127_7667164_4 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003157 254.0
HFD2_k127_7667164_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000001863 229.0
HFD2_k127_7667164_6 Endonuclease Exonuclease Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000001304 216.0
HFD2_k127_7667164_7 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000008632 189.0
HFD2_k127_7667164_8 Sortase family K07284 - 3.4.22.70 0.000000000000000000000000000000000000000000000003817 181.0
HFD2_k127_7667164_9 - - - - 0.00000000000000000000000000000000000000000000000785 179.0
HFD2_k127_7679749_0 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1557.0
HFD2_k127_7679749_1 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.0 1359.0
HFD2_k127_7679749_10 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 365.0
HFD2_k127_7679749_11 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 352.0
HFD2_k127_7679749_12 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 346.0
HFD2_k127_7679749_13 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 334.0
HFD2_k127_7679749_14 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001127 284.0
HFD2_k127_7679749_15 Heme copper-type cytochrome quinol oxidase, subunit K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006075 296.0
HFD2_k127_7679749_16 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003132 262.0
HFD2_k127_7679749_17 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001399 266.0
HFD2_k127_7679749_18 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000121 259.0
HFD2_k127_7679749_19 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000009915 250.0
HFD2_k127_7679749_2 Molybdopterin oxidoreductase, iron-sulfur binding subunit K00184 - - 2.997e-281 906.0
HFD2_k127_7679749_20 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000008113 249.0
HFD2_k127_7679749_21 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000007759 196.0
HFD2_k127_7679749_22 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000003633 198.0
HFD2_k127_7679749_23 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000005523 193.0
HFD2_k127_7679749_24 protein tyrosine kinase activity K03593 - - 0.000000000000000000000000000000000000000000000077 179.0
HFD2_k127_7679749_25 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000009739 183.0
HFD2_k127_7679749_26 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000001127 171.0
HFD2_k127_7679749_27 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.0000000000000000000000002572 117.0
HFD2_k127_7679749_28 cell redox homeostasis K02199,K03671 - - 0.0000000000000000000000004279 116.0
HFD2_k127_7679749_29 Glucose dehydrogenase C-terminus - - - 0.000000000000000000000004691 104.0
HFD2_k127_7679749_3 choline dehydrogenase activity - - - 8.17e-253 802.0
HFD2_k127_7679749_30 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000001593 106.0
HFD2_k127_7679749_31 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000000000000000345 94.0
HFD2_k127_7679749_33 COG2146 Ferredoxin subunits of nitrite reductase and K00363,K05710 - 1.7.1.15 0.000000000000000000508 103.0
HFD2_k127_7679749_34 High potential iron-sulfur protein - - - 0.00000000000001603 79.0
HFD2_k127_7679749_36 - - - - 0.000007936 57.0
HFD2_k127_7679749_37 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.000246 53.0
HFD2_k127_7679749_38 - - - - 0.0003874 48.0
HFD2_k127_7679749_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 9.136e-249 780.0
HFD2_k127_7679749_5 Polysulphide reductase, NrfD K00185 - - 2.136e-236 744.0
HFD2_k127_7679749_6 Polysulphide reductase K00185 - - 2.165e-221 697.0
HFD2_k127_7679749_7 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 543.0
HFD2_k127_7679749_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 379.0
HFD2_k127_7679749_9 Proto-chlorophyllide reductase 57 kD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 370.0
HFD2_k127_7792353_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 535.0
HFD2_k127_7792353_1 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000000002785 156.0
HFD2_k127_7792353_2 coenzyme F390 K01912 - 6.2.1.30 0.00000000000000000000000000000000001038 147.0
HFD2_k127_7792353_3 nucleotidyltransferase activity - - - 0.0000000000007203 82.0
HFD2_k127_7915932_0 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000685 269.0
HFD2_k127_7915932_1 hopanoid biosynthesis associated protein HpnK K03478 - 3.5.1.105 0.0000000000001088 74.0
HFD2_k127_7915932_2 cellulose binding - - - 0.0000000000003118 80.0
HFD2_k127_7981689_0 Cupin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 318.0
HFD2_k127_7981689_1 domain protein K01081,K01347,K07004,K13735,K17624,K20276 - 3.1.3.5,3.2.1.97,3.4.21.72 0.0000000000000000000000000000000000000000000000000000000000000000000000004173 276.0
HFD2_k127_7981689_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000003704 204.0
HFD2_k127_7981689_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000188 94.0
HFD2_k127_7981689_5 - - - - 0.0000005872 55.0
HFD2_k127_7981689_6 Membrane - - - 0.000007611 55.0
HFD2_k127_8025100_0 COG1228 Imidazolonepropionase and related K01443 - 3.5.1.25 5.252e-197 651.0
HFD2_k127_8025100_1 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 436.0
HFD2_k127_8025100_2 AcrB/AcrD/AcrF family K03296 - - 0.000000000000000000000001278 116.0
HFD2_k127_8025100_3 Amidohydrolase family - - - 0.00000000000000000000004356 104.0
HFD2_k127_8025100_4 Protein of unknown function (DUF1573) - - - 0.0000000006599 69.0
HFD2_k127_8044613_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 550.0
HFD2_k127_8044613_1 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 474.0
HFD2_k127_8044613_10 -O-antigen K02847,K13009,K16705 GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.00000000058 74.0
HFD2_k127_8044613_11 Methyltransferase - - - 0.0000002569 64.0
HFD2_k127_8044613_12 -O-antigen - - - 0.000001581 61.0
HFD2_k127_8044613_2 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004901 267.0
HFD2_k127_8044613_3 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000001831 213.0
HFD2_k127_8044613_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000227 220.0
HFD2_k127_8044613_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000005623 191.0
HFD2_k127_8044613_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000363 158.0
HFD2_k127_8044613_7 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000007331 117.0
HFD2_k127_8044613_8 response regulator K02667 - - 0.0000000000001855 72.0
HFD2_k127_8044613_9 Polysaccharide biosynthesis protein - - - 0.0000000000005154 81.0
HFD2_k127_8059851_0 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 421.0
HFD2_k127_8059851_1 - - - - 0.0000000000000000000000000000000000000000000002301 175.0
HFD2_k127_8059851_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000008094 175.0
HFD2_k127_8059851_4 Multicopper oxidase K06324 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0016722,GO:0052716,GO:0055114 1.16.3.3 0.0000000000000000000000000000006644 134.0
HFD2_k127_8083529_0 OmpA family - - - 0.0 1974.0
HFD2_k127_8083529_1 Domain of unknown function DUF11 - - - 0.0 1468.0
HFD2_k127_8083529_10 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 541.0
HFD2_k127_8083529_11 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 396.0
HFD2_k127_8083529_12 Poly (ADP-ribose) glycohydrolase (PARG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 306.0
HFD2_k127_8083529_13 Activator of Hsp90 ATPase 1 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003938 258.0
HFD2_k127_8083529_14 - - - - 0.0000000000000000000000000000000000000000000000000000004994 199.0
HFD2_k127_8083529_15 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000615 178.0
HFD2_k127_8083529_16 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000001972 172.0
HFD2_k127_8083529_17 YCII-related domain - - - 0.00000000000000000000000000000000000000000003432 164.0
HFD2_k127_8083529_18 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000008115 173.0
HFD2_k127_8083529_19 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000381 146.0
HFD2_k127_8083529_2 PNKP adenylyltransferase domain, ligase domain - - - 0.0 1250.0
HFD2_k127_8083529_20 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000000000000001108 103.0
HFD2_k127_8083529_21 Hep Hag repeat protein - - - 0.000000000000000000001036 111.0
HFD2_k127_8083529_22 - - - - 0.000000000001181 79.0
HFD2_k127_8083529_23 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000002652 73.0
HFD2_k127_8083529_24 NADP oxidoreductase coenzyme F420-dependent - - - 0.000000003247 61.0
HFD2_k127_8083529_25 PFAM aldo keto reductase K05275 - 1.1.1.65 0.00000006059 66.0
HFD2_k127_8083529_3 Tetratricopeptide repeat - - - 1.139e-313 1007.0
HFD2_k127_8083529_4 Sigma-54 dependent transcriptional regulator K14414 - - 1.324e-216 685.0
HFD2_k127_8083529_5 Tetratricopeptide repeat - - - 4.23e-216 687.0
HFD2_k127_8083529_6 RNA repair, ligase-Pnkp-associating, region of Hen1 - - - 1.071e-213 672.0
HFD2_k127_8083529_7 helix_turn_helix, Lux Regulon - - - 3.163e-212 674.0
HFD2_k127_8083529_8 positive regulation of ATPase activity K11089 - - 2.63e-197 627.0
HFD2_k127_8083529_9 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 586.0
HFD2_k127_8104710_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 614.0
HFD2_k127_8104710_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 546.0
HFD2_k127_8104710_10 Histidine kinase K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000003839 214.0
HFD2_k127_8104710_11 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000002006 180.0
HFD2_k127_8104710_12 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000003148 175.0
HFD2_k127_8104710_13 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000001212 185.0
HFD2_k127_8104710_14 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000000003601 164.0
HFD2_k127_8104710_15 - - - - 0.000000000000000000000000000000000000002479 150.0
HFD2_k127_8104710_16 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000002089 141.0
HFD2_k127_8104710_17 acyltransferase K00655 - 2.3.1.51 0.0000000000000001033 90.0
HFD2_k127_8104710_18 Acetyltransferase (GNAT) domain - - - 0.000000000001305 70.0
HFD2_k127_8104710_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 434.0
HFD2_k127_8104710_20 repeat-containing protein - - - 0.0000006513 61.0
HFD2_k127_8104710_21 Putative adhesin - - - 0.00001359 57.0
HFD2_k127_8104710_22 Phosphopantetheine attachment site - - - 0.0003277 47.0
HFD2_k127_8104710_3 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 432.0
HFD2_k127_8104710_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 353.0
HFD2_k127_8104710_5 Cys/Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 341.0
HFD2_k127_8104710_6 Belongs to the glycosyl hydrolase 13 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004651 321.0
HFD2_k127_8104710_7 Phosphopantetheine attachment site - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000773 299.0
HFD2_k127_8104710_8 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004937 274.0
HFD2_k127_8104710_9 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000851 223.0
HFD2_k127_8115756_0 Carbamoyltransferase C-terminus K00612 - - 3.159e-256 803.0
HFD2_k127_8115756_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007133 407.0
HFD2_k127_8115756_10 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000003848 205.0
HFD2_k127_8115756_11 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000003672 204.0
HFD2_k127_8115756_12 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000001065 201.0
HFD2_k127_8115756_13 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000004716 181.0
HFD2_k127_8115756_14 HlyD family secretion protein K02005 - - 0.0000000000000000000000000002281 133.0
HFD2_k127_8115756_15 lipolytic protein G-D-S-L family - - - 0.000000000000000000000002763 116.0
HFD2_k127_8115756_16 HlyD family secretion protein - - - 0.0000000000000000000001824 111.0
HFD2_k127_8115756_17 YbbR-like protein - - - 0.00000000000000000008504 102.0
HFD2_k127_8115756_18 - - - - 0.000000000008008 68.0
HFD2_k127_8115756_19 - - - - 0.0008753 49.0
HFD2_k127_8115756_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 365.0
HFD2_k127_8115756_3 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 351.0
HFD2_k127_8115756_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 338.0
HFD2_k127_8115756_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004944 339.0
HFD2_k127_8115756_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002188 287.0
HFD2_k127_8115756_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000004722 264.0
HFD2_k127_8115756_8 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005177 273.0
HFD2_k127_8115756_9 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.000000000000000000000000000000000000000000000000000000000000000000001034 256.0
HFD2_k127_8124524_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 620.0
HFD2_k127_8124524_1 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 593.0
HFD2_k127_8124524_10 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000227 207.0
HFD2_k127_8124524_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000992 214.0
HFD2_k127_8124524_12 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000005894 175.0
HFD2_k127_8124524_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000001016 168.0
HFD2_k127_8124524_14 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000001114 150.0
HFD2_k127_8124524_15 - K07018 - - 0.000000000000000000000000000000001058 144.0
HFD2_k127_8124524_16 Ferredoxin - - - 0.000000000000000000000000000000004326 137.0
HFD2_k127_8124524_17 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000006817 149.0
HFD2_k127_8124524_18 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000006598 138.0
HFD2_k127_8124524_19 Transcriptional regulator - - - 0.000000000000000000000000002174 117.0
HFD2_k127_8124524_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009121 551.0
HFD2_k127_8124524_20 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000001106 111.0
HFD2_k127_8124524_22 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.00000003189 61.0
HFD2_k127_8124524_23 cellulase activity - - - 0.000006454 59.0
HFD2_k127_8124524_3 Proton-conducting membrane transporter K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 471.0
HFD2_k127_8124524_4 proline dipeptidase activity K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 383.0
HFD2_k127_8124524_5 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 345.0
HFD2_k127_8124524_6 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 312.0
HFD2_k127_8124524_7 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 291.0
HFD2_k127_8124524_8 synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008301 286.0
HFD2_k127_8124524_9 PFAM HhH-GPD superfamily base excision DNA repair protein K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000201 284.0
HFD2_k127_8182755_0 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001411 294.0
HFD2_k127_8182755_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000002213 184.0
HFD2_k127_8182755_2 HEPN domain - - - 0.0000000000000000000000000000000000001141 150.0
HFD2_k127_8182755_3 Nucleotidyltransferase domain - - - 0.000000000000000000000000000000001253 133.0
HFD2_k127_8182755_4 Predicted membrane protein (DUF2157) - - - 0.00000000000000000000000001781 125.0
HFD2_k127_8280575_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000008333 180.0
HFD2_k127_8280575_1 Transmembrane and TPR repeat-containing protein - - - 0.0000000000004649 82.0
HFD2_k127_8280575_2 Propeptide_C25 - - - 0.00000000007628 74.0
HFD2_k127_8280575_3 PFAM coenzyme PQQ synthesis - - - 0.0005505 50.0
HFD2_k127_835418_0 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 433.0
HFD2_k127_835418_1 G-rich domain on putative tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 417.0
HFD2_k127_835418_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 407.0
HFD2_k127_835418_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000001771 170.0
HFD2_k127_835418_4 Phosphomethylpyrimidine kinase K00941 GO:0008150,GO:0040007 2.7.1.49,2.7.4.7 0.00000000000002998 84.0
HFD2_k127_835418_5 PBS lyase HEAT-like repeat - - - 0.00000000008125 74.0
HFD2_k127_835418_6 peptidyl-tyrosine sulfation - - - 0.0000000001133 68.0
HFD2_k127_835418_7 - - - - 0.0004646 47.0
HFD2_k127_8535842_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.264e-255 807.0
HFD2_k127_8535842_1 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 6.494e-250 783.0
HFD2_k127_8535842_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 424.0
HFD2_k127_8535842_11 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 371.0
HFD2_k127_8535842_12 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 366.0
HFD2_k127_8535842_13 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 324.0
HFD2_k127_8535842_14 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 307.0
HFD2_k127_8535842_15 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 299.0
HFD2_k127_8535842_16 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002089 262.0
HFD2_k127_8535842_17 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000008517 147.0
HFD2_k127_8535842_18 Thioesterase superfamily - - - 0.00000000000000000000000000000000003348 141.0
HFD2_k127_8535842_19 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K00627,K01571,K02160 - 2.3.1.12,4.1.1.3 0.0000000000000000000000000000000004393 142.0
HFD2_k127_8535842_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 3.862e-210 672.0
HFD2_k127_8535842_20 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000001934 146.0
HFD2_k127_8535842_21 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000004421 134.0
HFD2_k127_8535842_22 PFAM Pilus assembly protein PilO K02664 - - 0.000000000000000000002965 104.0
HFD2_k127_8535842_23 Preprotein translocase, YajC K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000009264 93.0
HFD2_k127_8535842_24 Ribosomal L28 family K02902 - - 0.0000000000000001001 82.0
HFD2_k127_8535842_25 Fimbrial assembly protein (PilN) K02663 - - 0.00000000000008432 80.0
HFD2_k127_8535842_26 Tetratricopeptide repeat - - - 0.000000000008124 78.0
HFD2_k127_8535842_27 Pfam:N_methyl_2 - - - 0.000000001946 61.0
HFD2_k127_8535842_28 PFAM iron dependent repressor K03709 - - 0.00000003121 62.0
HFD2_k127_8535842_3 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 637.0
HFD2_k127_8535842_4 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 599.0
HFD2_k127_8535842_5 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 549.0
HFD2_k127_8535842_6 cell shape determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 537.0
HFD2_k127_8535842_7 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 473.0
HFD2_k127_8535842_8 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 456.0
HFD2_k127_8535842_9 Two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 460.0
HFD2_k127_8662780_0 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000001201 203.0
HFD2_k127_8662780_1 PFAM von Willebrand factor type A K07114 - - 0.0000000000000000000000000001979 131.0
HFD2_k127_8662780_2 peptidyl-tyrosine sulfation - - - 0.0001769 49.0
HFD2_k127_8662780_3 PFAM TonB-dependent Receptor Plug Domain - - - 0.000747 50.0
HFD2_k127_933280_0 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004706 246.0
HFD2_k127_933280_1 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000003046 241.0
HFD2_k127_933280_2 Thioesterase superfamily - - - 0.0000000000000000000000000000000000792 139.0
HFD2_k127_933280_3 SnoaL-like domain - - - 0.000000000000000006907 86.0
HFD2_k127_937632_0 cellulose binding - - - 3.724e-300 962.0
HFD2_k127_937632_1 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 8.102e-219 695.0
HFD2_k127_937632_10 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 527.0
HFD2_k127_937632_11 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005055 482.0
HFD2_k127_937632_12 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 442.0
HFD2_k127_937632_13 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 423.0
HFD2_k127_937632_14 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 405.0
HFD2_k127_937632_15 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 407.0
HFD2_k127_937632_16 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005153 404.0
HFD2_k127_937632_17 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 418.0
HFD2_k127_937632_18 Penicillin-binding protein, transpeptidase domain protein K03587,K08384 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 395.0
HFD2_k127_937632_19 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 365.0
HFD2_k127_937632_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 2.515e-208 670.0
HFD2_k127_937632_20 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 349.0
HFD2_k127_937632_21 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 326.0
HFD2_k127_937632_22 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 328.0
HFD2_k127_937632_23 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 307.0
HFD2_k127_937632_24 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 315.0
HFD2_k127_937632_25 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 290.0
HFD2_k127_937632_26 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001703 290.0
HFD2_k127_937632_27 Domain of unknown function (DUF4129) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000036 285.0
HFD2_k127_937632_28 ATPase activity K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000105 293.0
HFD2_k127_937632_29 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004067 273.0
HFD2_k127_937632_3 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 552.0
HFD2_k127_937632_30 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000000001647 257.0
HFD2_k127_937632_31 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000007601 259.0
HFD2_k127_937632_32 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.000000000000000000000000000000000000000000000000000000000000000000000004983 269.0
HFD2_k127_937632_33 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000001266 272.0
HFD2_k127_937632_34 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000009045 251.0
HFD2_k127_937632_35 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000000000000000000000001159 197.0
HFD2_k127_937632_36 PFAM secretion protein HlyD family protein K01993 - - 0.000000000000000000000000000000000000000000000001464 186.0
HFD2_k127_937632_37 membrane protein domain - - - 0.000000000000000000000000000000000000000000000003698 199.0
HFD2_k127_937632_38 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000001905 169.0
HFD2_k127_937632_39 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000206 153.0
HFD2_k127_937632_4 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 541.0
HFD2_k127_937632_40 Domain of unknown function (DUF4350) - - - 0.000000000000000000000000000000000000009946 167.0
HFD2_k127_937632_41 Diguanylate cyclase - - - 0.00000000000000000000000000000000000008698 150.0
HFD2_k127_937632_42 chlorophyll binding K02051,K03286 - - 0.0000000000000000000000000000000000001956 149.0
HFD2_k127_937632_43 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000000008124 152.0
HFD2_k127_937632_44 Lysin motif K06194 - - 0.000000000000000000000000000000000009975 159.0
HFD2_k127_937632_45 von Willebrand factor, type A - - - 0.000000000000000000000000000000004657 141.0
HFD2_k127_937632_46 Outer membrane efflux protein - - - 0.0000000000000000000000000001555 134.0
HFD2_k127_937632_47 aminopeptidase - - - 0.0000000000000000000000000005342 134.0
HFD2_k127_937632_48 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000001132 116.0
HFD2_k127_937632_49 Periplasmic or secreted lipoprotein - - - 0.000000000000000007384 98.0
HFD2_k127_937632_5 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 562.0
HFD2_k127_937632_50 transcriptional regulator K09017 - - 0.00000000000000001766 91.0
HFD2_k127_937632_51 response regulator receiver K02490 - - 0.0000000000000135 79.0
HFD2_k127_937632_52 - - - - 0.00000000000002471 84.0
HFD2_k127_937632_53 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000001074 62.0
HFD2_k127_937632_54 Protein of unknown function (DUF1054) - - - 0.0000003661 61.0
HFD2_k127_937632_55 Response regulator receiver K02488 - 2.7.7.65 0.0000005273 63.0
HFD2_k127_937632_56 transcriptional regulator, SARP family - - - 0.0000006287 61.0
HFD2_k127_937632_57 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00002658 55.0
HFD2_k127_937632_58 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.00007903 56.0
HFD2_k127_937632_59 Thioredoxin-like - - - 0.00008725 54.0
HFD2_k127_937632_6 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 509.0
HFD2_k127_937632_61 Tetratricopeptide repeat - - - 0.0001122 55.0
HFD2_k127_937632_62 Serine aminopeptidase, S33 K22319 - 6.1.3.1 0.0005785 52.0
HFD2_k127_937632_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 504.0
HFD2_k127_937632_8 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 495.0
HFD2_k127_937632_9 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 519.0
HFD2_k127_960369_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1083.0
HFD2_k127_960369_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 600.0
HFD2_k127_960369_10 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 310.0
HFD2_k127_960369_11 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001532 276.0
HFD2_k127_960369_12 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005707 271.0
HFD2_k127_960369_13 Polysaccharide biosynthesis protein K15891 - 1.1.1.354 0.0000000000000000000000000000000000000000000000000000000000000000000000003858 273.0
HFD2_k127_960369_14 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008136 252.0
HFD2_k127_960369_15 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000004207 238.0
HFD2_k127_960369_16 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000008556 260.0
HFD2_k127_960369_17 Serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000005213 231.0
HFD2_k127_960369_18 metallopeptidase activity K03592 - - 0.000000000000000000000000000000000000000000000000000000000001576 238.0
HFD2_k127_960369_19 PLD-like domain K06131 - - 0.000000000000000000000000000000000000000000000000000000000006177 222.0
HFD2_k127_960369_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 578.0
HFD2_k127_960369_20 PSP1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000007049 214.0
HFD2_k127_960369_21 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000008814 214.0
HFD2_k127_960369_22 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000007694 214.0
HFD2_k127_960369_23 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000006942 203.0
HFD2_k127_960369_24 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774,K22110 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 - 0.00000000000000000000000000000000000000000000000002387 206.0
HFD2_k127_960369_25 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000001935 179.0
HFD2_k127_960369_26 ribose 5-phosphate isomerase B K01808 - 5.3.1.6 0.000000000000000000000000000000000000000001806 177.0
HFD2_k127_960369_27 PFAM Integral membrane protein DUF92 - GO:0005575,GO:0016020 - 0.0000000000000000000000000000000000003413 157.0
HFD2_k127_960369_28 - - - - 0.0000000000000000000000000000000001604 144.0
HFD2_k127_960369_29 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000002982 144.0
HFD2_k127_960369_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007501 554.0
HFD2_k127_960369_30 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000001021 122.0
HFD2_k127_960369_31 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000002887 103.0
HFD2_k127_960369_32 diguanylate cyclase - - - 0.000000000000000001738 99.0
HFD2_k127_960369_33 Transcriptional K07979 - - 0.000000000000000004077 89.0
HFD2_k127_960369_34 Glycosyl transferase - - - 0.000000000000000008648 99.0
HFD2_k127_960369_35 Bacterial membrane protein, YfhO - - - 0.00000000000000003278 97.0
HFD2_k127_960369_36 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000002028 87.0
HFD2_k127_960369_37 Thiamin pyrophosphokinase, vitamin B1 binding domain K00949 - 2.7.6.2 0.00000000000005898 81.0
HFD2_k127_960369_38 - - - - 0.0000000004319 71.0
HFD2_k127_960369_39 Sigma-70 region 2 K03088 - - 0.0000001623 61.0
HFD2_k127_960369_4 ABC transporter K06022,K06158,K10834 - 3.6.3.29,3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 530.0
HFD2_k127_960369_40 Glutamate synthase - - - 0.000001654 61.0
HFD2_k127_960369_41 Bacterial membrane protein, YfhO - - - 0.000004718 60.0
HFD2_k127_960369_42 - - - - 0.00001045 59.0
HFD2_k127_960369_5 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 548.0
HFD2_k127_960369_6 proline dipeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 416.0
HFD2_k127_960369_7 metallopeptidase activity K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 381.0
HFD2_k127_960369_8 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 336.0
HFD2_k127_960369_9 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 332.0
HFD2_k127_973638_0 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.0 1098.0
HFD2_k127_973638_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.931e-262 863.0
HFD2_k127_973638_10 response regulator K07713 - - 0.00000000000000000000000000000000000000000000000000154 206.0
HFD2_k127_973638_11 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000002871 198.0
HFD2_k127_973638_12 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation K03800 - 6.3.1.20 0.00000000000000000000000000000000000000000000001224 188.0
HFD2_k127_973638_13 Cytochrome c K00406 - - 0.000000000000000000000000000000000000000000003336 173.0
HFD2_k127_973638_14 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000000000007905 173.0
HFD2_k127_973638_15 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000000000000000000001732 157.0
HFD2_k127_973638_16 Belongs to the UPF0109 family K06960 - - 0.0000000000000000000000005074 111.0
HFD2_k127_973638_17 Riboflavin synthase K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.0000000000000000000008502 97.0
HFD2_k127_973638_18 FixH - - - 0.00000000000000000004804 105.0
HFD2_k127_973638_19 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000261 89.0
HFD2_k127_973638_2 Putative metal-binding domain of cation transport ATPase K01533 - 3.6.3.4 2.522e-224 722.0
HFD2_k127_973638_20 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000001057 79.0
HFD2_k127_973638_21 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000001717 86.0
HFD2_k127_973638_23 PA14 domain - - - 0.000000001935 71.0
HFD2_k127_973638_24 Putative metal-binding motif - - - 0.000000253 64.0
HFD2_k127_973638_25 Methyltransferase domain - - - 0.0000003725 64.0
HFD2_k127_973638_26 Cytochrome oxidase maturation protein cbb3-type - - - 0.00001872 58.0
HFD2_k127_973638_3 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 575.0
HFD2_k127_973638_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 528.0
HFD2_k127_973638_5 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 483.0
HFD2_k127_973638_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 479.0
HFD2_k127_973638_7 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007261 352.0
HFD2_k127_973638_8 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000003627 253.0
HFD2_k127_973638_9 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000002496 259.0
HFD2_k127_981941_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 354.0
HFD2_k127_981941_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 309.0
HFD2_k127_981941_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000005651 195.0
HFD2_k127_981941_3 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000002296 189.0
HFD2_k127_981941_4 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000005709 156.0
HFD2_k127_981941_5 chaperone-mediated protein folding - - - 0.000000000000000004837 100.0
HFD2_k127_981941_6 Glycosyl transferase, family 2 K00786 - - 0.000000000000000006571 99.0
HFD2_k127_981941_8 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000004853 86.0
HFD2_k127_981941_9 Methyltransferase type 11 - - - 0.0000000004803 71.0