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Overview

ID MAG01651
Name HFD2_bin.40
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family GWC2-71-9
Genus JADJOM01
Species
Assembly information
Completeness (%) 86.06
Contamination (%) 0.88
GC content (%) 69.0
N50 (bp) 51,574
Genome size (bp) 4,205,901

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3363

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1010884_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 564.0
HFD2_k127_1010884_1 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 559.0
HFD2_k127_1010884_2 proline dipeptidase activity K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 464.0
HFD2_k127_1010884_3 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 443.0
HFD2_k127_1010884_4 Domain of unknown function(DUF2779) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 372.0
HFD2_k127_1010884_5 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002258 253.0
HFD2_k127_1010884_6 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000165 190.0
HFD2_k127_1010884_7 HNH nucleases - - - 0.00000000000000000000000000000009304 132.0
HFD2_k127_1010884_8 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.0003039 45.0
HFD2_k127_1011697_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.896e-221 712.0
HFD2_k127_1011697_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 563.0
HFD2_k127_1011697_10 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005512 323.0
HFD2_k127_1011697_11 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000005337 255.0
HFD2_k127_1011697_12 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008363 261.0
HFD2_k127_1011697_13 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000009107 203.0
HFD2_k127_1011697_14 Fimbrial assembly protein (PilN) - - - 0.0000000000000000000000000000000001498 141.0
HFD2_k127_1011697_15 - - - - 0.000000000000000000000000000000002268 139.0
HFD2_k127_1011697_16 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000009569 135.0
HFD2_k127_1011697_17 diguanylate cyclase K13590 - 2.7.7.65 0.00000000000000000000000000002783 134.0
HFD2_k127_1011697_18 - - - - 0.0000000000000000006262 98.0
HFD2_k127_1011697_19 Tetratricopeptide repeat protein 24 - - - 0.000002975 60.0
HFD2_k127_1011697_2 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 563.0
HFD2_k127_1011697_20 Pilus assembly protein, PilO K02664 - - 0.00002329 54.0
HFD2_k127_1011697_21 Rhodanese domain protein - - - 0.0004827 44.0
HFD2_k127_1011697_3 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 548.0
HFD2_k127_1011697_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 507.0
HFD2_k127_1011697_5 AMIN domain K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 471.0
HFD2_k127_1011697_6 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 438.0
HFD2_k127_1011697_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005377 422.0
HFD2_k127_1011697_8 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 418.0
HFD2_k127_1011697_9 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 400.0
HFD2_k127_1015216_0 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000006566 164.0
HFD2_k127_1015216_1 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000004595 102.0
HFD2_k127_1015216_2 Domain of unknown function (DUF4349) - - - 0.000004795 54.0
HFD2_k127_1049174_0 PFAM Integrase catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 359.0
HFD2_k127_1049174_1 Major Facilitator Superfamily - - - 0.00000000000000000001428 95.0
HFD2_k127_1078024_0 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000000000000000000000452 109.0
HFD2_k127_1078024_1 - - - - 0.00000000000000004916 93.0
HFD2_k127_1078024_2 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000004361 60.0
HFD2_k127_1111171_0 peptidase S9B dipeptidylpeptidase IV domain protein - - - 1.906e-288 905.0
HFD2_k127_1111171_1 Aldehyde dehydrogenase family K00129 - 1.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 619.0
HFD2_k127_1111171_2 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006799 505.0
HFD2_k127_1111171_3 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 285.0
HFD2_k127_1111171_4 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000001343 186.0
HFD2_k127_1111171_5 - - - - 0.00000000000000000000000000005475 128.0
HFD2_k127_1111171_6 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000003146 97.0
HFD2_k127_1111171_7 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000005234 54.0
HFD2_k127_1143837_0 Zinc carboxypeptidase K14054 - - 0.0 1183.0
HFD2_k127_1143837_1 radical SAM domain protein - - - 6.43e-209 663.0
HFD2_k127_1143837_10 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.00000000000000000000000000000000000001051 154.0
HFD2_k127_1143837_11 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000009236 142.0
HFD2_k127_1143837_12 SnoaL-like domain - - - 0.00000000000000000000000000002948 129.0
HFD2_k127_1143837_13 Tetratricopeptide repeat - - - 0.00000000000000000000000002543 119.0
HFD2_k127_1143837_14 Protein of unknown function (DUF983) - - - 0.0000000000000000000000003745 110.0
HFD2_k127_1143837_15 Putative stress-induced transcription regulator - - - 0.00000000000000000004529 98.0
HFD2_k127_1143837_16 PFAM Pentapeptide repeats (8 copies) - - - 0.0000000000000000009794 96.0
HFD2_k127_1143837_18 PFAM glycoside hydrolase family 13 domain protein - - - 0.00000000000000005167 94.0
HFD2_k127_1143837_19 PFAM Cupin 2, conserved barrel domain protein K11312 - - 0.0000000000002207 78.0
HFD2_k127_1143837_2 ErfK YbiS YcfS YnhG family protein K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 400.0
HFD2_k127_1143837_20 - - - - 0.000000003979 69.0
HFD2_k127_1143837_21 PFAM glycoside hydrolase family 13 domain protein - - - 0.00005166 55.0
HFD2_k127_1143837_3 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002771 243.0
HFD2_k127_1143837_4 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000005099 241.0
HFD2_k127_1143837_5 zinc D-Ala-D-Ala carboxypeptidase activity K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000001463 222.0
HFD2_k127_1143837_6 AlkA N-terminal domain K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000001007 207.0
HFD2_k127_1143837_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000000000000000000000000000001805 169.0
HFD2_k127_1143837_8 Transcription elongation factor, N-terminal K03624 - - 0.0000000000000000000000000000000000000001424 155.0
HFD2_k127_1143837_9 Sigma-70, region 4 K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000002659 157.0
HFD2_k127_118571_0 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 504.0
HFD2_k127_1212513_0 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 317.0
HFD2_k127_1212513_1 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 310.0
HFD2_k127_1212513_2 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000003126 185.0
HFD2_k127_1212513_3 PFAM transposase mutator type K07493 - - 0.00000000002526 64.0
HFD2_k127_1215195_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1031.0
HFD2_k127_1215195_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1026.0
HFD2_k127_1215195_10 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 421.0
HFD2_k127_1215195_11 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 412.0
HFD2_k127_1215195_12 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 325.0
HFD2_k127_1215195_13 transferase activity, transferring glycosyl groups K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001154 280.0
HFD2_k127_1215195_14 with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000007856 273.0
HFD2_k127_1215195_15 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001391 267.0
HFD2_k127_1215195_16 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001428 262.0
HFD2_k127_1215195_17 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000001903 254.0
HFD2_k127_1215195_18 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000002103 246.0
HFD2_k127_1215195_19 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000001649 235.0
HFD2_k127_1215195_2 PQQ-like domain K00114 - 1.1.2.8 5.606e-223 709.0
HFD2_k127_1215195_20 Hpt domain - - - 0.000000000000000000000000000000000000000000000000000000000000002592 239.0
HFD2_k127_1215195_21 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000000000000000000000000000000000001089 215.0
HFD2_k127_1215195_22 Bacterial extracellular solute-binding proteins, family 3 K16254 - - 0.000000000000000000000000000000000000000000000000000000000002469 218.0
HFD2_k127_1215195_23 PFAM ThiJ PfpI K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000004536 212.0
HFD2_k127_1215195_24 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000003853 214.0
HFD2_k127_1215195_25 - - - - 0.00000000000000000000000000000000000000000000000000001959 203.0
HFD2_k127_1215195_26 Mazg nucleotide pyrophosphohydrolase K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000228 184.0
HFD2_k127_1215195_27 pilus organization K07004 - - 0.0000000000000000000000000000000000000000000001925 181.0
HFD2_k127_1215195_28 Pterin 4 alpha carbinolamine dehydratase K01724,K11991 - 3.5.4.33,4.2.1.96 0.000000000000000000000000000000000000000000001115 168.0
HFD2_k127_1215195_29 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000002004 150.0
HFD2_k127_1215195_3 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 2.665e-204 657.0
HFD2_k127_1215195_30 Pentapeptide repeats (9 copies) - - - 0.000000000000000000000000000000000005248 147.0
HFD2_k127_1215195_31 - K01633,K07144 - 1.13.11.81,2.7.4.31,4.1.2.25,5.1.99.8 0.0000000000000000000000000000009832 128.0
HFD2_k127_1215195_32 Alpha beta hydrolase - - - 0.0000000000000000000001304 112.0
HFD2_k127_1215195_33 methylamine metabolic process K03885,K16937 - 1.6.99.3,1.8.5.2 0.000000000000000000003547 101.0
HFD2_k127_1215195_34 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000001041 96.0
HFD2_k127_1215195_35 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000002243 83.0
HFD2_k127_1215195_36 Sugar-specific transcriptional regulator TrmB - - - 0.00000000001907 73.0
HFD2_k127_1215195_37 4-HFC-P synthase - - - 0.00000000002068 73.0
HFD2_k127_1215195_38 - - - - 0.0000000103 60.0
HFD2_k127_1215195_39 Rdx family K07401 - - 0.00000001946 57.0
HFD2_k127_1215195_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 589.0
HFD2_k127_1215195_40 Bacterial transcriptional activator domain - - - 0.0001406 54.0
HFD2_k127_1215195_41 cellular component assembly K11447,K16531 GO:0000003,GO:0000086,GO:0000226,GO:0000242,GO:0000278,GO:0000281,GO:0000288,GO:0000291,GO:0000785,GO:0000910,GO:0000956,GO:0001085,GO:0001103,GO:0001654,GO:0001708,GO:0001750,GO:0001754,GO:0001764,GO:0001838,GO:0001841,GO:0001843,GO:0001894,GO:0001895,GO:0001917,GO:0001947,GO:0002009,GO:0003006,GO:0003007,GO:0003008,GO:0003013,GO:0003073,GO:0003085,GO:0003143,GO:0003352,GO:0003356,GO:0003674,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005768,GO:0005794,GO:0005802,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005929,GO:0006139,GO:0006325,GO:0006401,GO:0006402,GO:0006464,GO:0006482,GO:0006725,GO:0006807,GO:0006810,GO:0006928,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007098,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007368,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0007507,GO:0007600,GO:0007606,GO:0007608,GO:0007610,GO:0008015,GO:0008064,GO:0008092,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008214,GO:0008217,GO:0009056,GO:0009057,GO:0009506,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009892,GO:0009933,GO:0009934,GO:0009987,GO:0009991,GO:0010033,GO:0010468,GO:0010564,GO:0010605,GO:0010629,GO:0010638,GO:0010639,GO:0012505,GO:0014020,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0016331,GO:0016358,GO:0016462,GO:0016477,GO:0016569,GO:0016570,GO:0016577,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019216,GO:0019221,GO:0019222,GO:0019439,GO:0019538,GO:0019953,GO:0021537,GO:0021543,GO:0021544,GO:0021591,GO:0021756,GO:0021761,GO:0021766,GO:0021915,GO:0021987,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022603,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030054,GO:0030154,GO:0030182,GO:0030534,GO:0030832,GO:0030833,GO:0030837,GO:0030900,GO:0031023,GO:0031090,GO:0031175,GO:0031253,GO:0031333,GO:0031344,GO:0031346,GO:0031410,GO:0031514,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0031984,GO:0032095,GO:0032096,GO:0032098,GO:0032099,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032231,GO:0032271,GO:0032272,GO:0032391,GO:0032400,GO:0032401,GO:0032402,GO:0032465,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032535,GO:0032870,GO:0032879,GO:0032886,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0033059,GO:0033210,GO:0033365,GO:0034097,GO:0034260,GO:0034451,GO:0034452,GO:0034453,GO:0034454,GO:0034464,GO:0034504,GO:0034613,GO:0034641,GO:0034655,GO:0034708,GO:0035050,GO:0035097,GO:0035148,GO:0035176,GO:0035239,GO:0035295,GO:0035327,GO:0035845,GO:0035869,GO:0036064,GO:0036211,GO:0038108,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040018,GO:0042221,GO:0042461,GO:0042462,GO:0042592,GO:0042995,GO:0043005,GO:0043009,GO:0043014,GO:0043086,GO:0043087,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043412,GO:0043473,GO:0043928,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044320,GO:0044321,GO:0044380,GO:0044422,GO:0044424,GO:0044425,GO:0044427,GO:0044428,GO:0044430,GO:0044431,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044451,GO:0044459,GO:0044463,GO:0044464,GO:0044666,GO:0044703,GO:0044770,GO:0044772,GO:0044782,GO:0044839,GO:0045165,GO:0045185,GO:0045444,GO:0045494,GO:0045724,GO:0045776,GO:0045927,GO:0046483,GO:0046530,GO:0046548,GO:0046700,GO:0046907,GO:0048232,GO:0048468,GO:0048487,GO:0048507,GO:0048509,GO:0048513,GO:0048515,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048532,GO:0048562,GO:0048568,GO:0048583,GO:0048585,GO:0048592,GO:0048598,GO:0048609,GO:0048638,GO:0048639,GO:0048646,GO:0048666,GO:0048699,GO:0048729,GO:0048731,GO:0048854,GO:0048856,GO:0048869,GO:0048870,GO:0048871,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050877,GO:0050890,GO:0050893,GO:0050896,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051270,GO:0051276,GO:0051301,GO:0051302,GO:0051336,GO:0051346,GO:0051457,GO:0051492,GO:0051493,GO:0051494,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051651,GO:0051656,GO:0051674,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0051726,GO:0051875,GO:0051904,GO:0051905,GO:0055044,GO:0055087,GO:0060170,GO:0060249,GO:0060255,GO:0060271,GO:0060295,GO:0060296,GO:0060322,GO:0060324,GO:0060429,GO:0060491,GO:0060562,GO:0060606,GO:0060612,GO:0060613,GO:0060632,GO:0061371,GO:0061448,GO:0061512,GO:0061640,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070076,GO:0070491,GO:0070727,GO:0070887,GO:0070925,GO:0070988,GO:0071310,GO:0071345,GO:0071495,GO:0071539,GO:0071557,GO:0071704,GO:0071840,GO:0071944,GO:0072175,GO:0072359,GO:0072393,GO:0072595,GO:0072698,GO:0080090,GO:0090066,GO:0090304,GO:0090596,GO:0097458,GO:0097499,GO:0097708,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0098791,GO:0110020,GO:0110053,GO:0120025,GO:0120031,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:1901360,GO:1901361,GO:1901564,GO:1901575,GO:1902017,GO:1902019,GO:1902115,GO:1902117,GO:1902494,GO:1902855,GO:1902903,GO:1902904,GO:1903047,GO:1903546,GO:1905508,GO:1905515,GO:1990234,GO:2000145 - 0.0003809 52.0
HFD2_k127_1215195_5 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 484.0
HFD2_k127_1215195_6 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 475.0
HFD2_k127_1215195_7 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 445.0
HFD2_k127_1215195_8 Anthranilate synthase component I, N terminal region K01665 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 437.0
HFD2_k127_1215195_9 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 419.0
HFD2_k127_1351106_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1182.0
HFD2_k127_1351106_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1168.0
HFD2_k127_1351106_10 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000005841 254.0
HFD2_k127_1351106_11 hydrolase of the alpha beta superfamily K07017 - - 0.000000000000000000000000000000000000000000000000007384 199.0
HFD2_k127_1351106_12 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.00000000000000000000000000000000000000000000004026 174.0
HFD2_k127_1351106_13 - - - - 0.000000000000000001526 100.0
HFD2_k127_1351106_14 - - - - 0.0000003026 63.0
HFD2_k127_1351106_15 - - - - 0.00006553 55.0
HFD2_k127_1351106_2 AcrB/AcrD/AcrF family K03296 - - 3.818e-304 980.0
HFD2_k127_1351106_3 Dehydrogenase K00117 - 1.1.5.2 5.16e-203 659.0
HFD2_k127_1351106_4 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 587.0
HFD2_k127_1351106_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 346.0
HFD2_k127_1351106_6 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001987 261.0
HFD2_k127_1351106_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001021 265.0
HFD2_k127_1351106_8 Clp protease K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000001307 252.0
HFD2_k127_1351106_9 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007048 239.0
HFD2_k127_1419059_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 560.0
HFD2_k127_1419059_1 HlyD family secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 535.0
HFD2_k127_1419059_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007348 506.0
HFD2_k127_1419059_3 Peptidase S8 K08651 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 500.0
HFD2_k127_1419059_4 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009999 495.0
HFD2_k127_1419059_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 405.0
HFD2_k127_1419059_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 380.0
HFD2_k127_1419059_7 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 334.0
HFD2_k127_1458854_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1054.0
HFD2_k127_1458854_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 484.0
HFD2_k127_1458854_10 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 319.0
HFD2_k127_1458854_11 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 307.0
HFD2_k127_1458854_12 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 301.0
HFD2_k127_1458854_13 Small GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000502 268.0
HFD2_k127_1458854_14 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000366 273.0
HFD2_k127_1458854_15 CheC-like family K03410 - - 0.00000000000000000000000000000000000000000000000000000000000156 226.0
HFD2_k127_1458854_16 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000001651 236.0
HFD2_k127_1458854_17 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000004136 211.0
HFD2_k127_1458854_18 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000006998 205.0
HFD2_k127_1458854_19 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000000000000000000000000000000000000000000002691 206.0
HFD2_k127_1458854_2 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 442.0
HFD2_k127_1458854_20 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000009042 173.0
HFD2_k127_1458854_21 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000000000000000009036 143.0
HFD2_k127_1458854_22 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000001949 128.0
HFD2_k127_1458854_23 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000003872 132.0
HFD2_k127_1458854_24 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000002419 136.0
HFD2_k127_1458854_25 - - - - 0.00000000000000000000000000003206 128.0
HFD2_k127_1458854_26 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000023 114.0
HFD2_k127_1458854_27 Tetratricopeptide repeat - - - 0.0000000000000000001653 103.0
HFD2_k127_1458854_28 Two component signalling adaptor domain K03408 - - 0.000000000005092 72.0
HFD2_k127_1458854_29 Roadblock/LC7 domain - - - 0.000000007406 66.0
HFD2_k127_1458854_3 P2 response regulator binding domain K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 431.0
HFD2_k127_1458854_30 Tetratricopeptide repeat - - - 0.000001531 59.0
HFD2_k127_1458854_31 Two component signalling adaptor domain - - - 0.00008598 54.0
HFD2_k127_1458854_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 441.0
HFD2_k127_1458854_5 Bacterial dnaA protein K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 427.0
HFD2_k127_1458854_6 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008836 407.0
HFD2_k127_1458854_7 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 377.0
HFD2_k127_1458854_8 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 348.0
HFD2_k127_1458854_9 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 334.0
HFD2_k127_1466778_0 fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 412.0
HFD2_k127_1466778_1 - - - - 0.000000000000000000000000000000000000000000000000000001976 206.0
HFD2_k127_1466778_2 cyclopropane-fatty-acyl-phospholipid synthase K00574,K20238 - 2.1.1.317,2.1.1.79 0.00000000000000000000000000000000000000000000000002809 192.0
HFD2_k127_1466778_3 PFAM peptidase M55 D-aminopeptidase - - - 0.00000000000000000000003087 108.0
HFD2_k127_1488459_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 8.005e-280 871.0
HFD2_k127_1488459_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 526.0
HFD2_k127_1488459_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 368.0
HFD2_k127_1488459_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 315.0
HFD2_k127_1488459_12 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 317.0
HFD2_k127_1488459_13 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 331.0
HFD2_k127_1488459_14 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 308.0
HFD2_k127_1488459_15 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000006503 261.0
HFD2_k127_1488459_16 imidazoleglycerol-phosphate dehydratase activity K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000002201 241.0
HFD2_k127_1488459_17 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000007031 235.0
HFD2_k127_1488459_18 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000000000005359 203.0
HFD2_k127_1488459_19 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000004771 205.0
HFD2_k127_1488459_2 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 512.0
HFD2_k127_1488459_20 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000002362 194.0
HFD2_k127_1488459_21 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000002973 184.0
HFD2_k127_1488459_22 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000009405 156.0
HFD2_k127_1488459_23 NUDIX domain K08310 - 3.6.1.67 0.00000000000000000000000000000000000003889 149.0
HFD2_k127_1488459_24 Transcriptional regulator - - - 0.0000005238 59.0
HFD2_k127_1488459_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 479.0
HFD2_k127_1488459_4 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 458.0
HFD2_k127_1488459_5 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 409.0
HFD2_k127_1488459_6 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 400.0
HFD2_k127_1488459_7 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000782 361.0
HFD2_k127_1488459_8 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 365.0
HFD2_k127_1488459_9 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 382.0
HFD2_k127_1596704_0 Glutamine synthetase type III K01915 - 6.3.1.2 1.742e-276 871.0
HFD2_k127_1596704_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007466 450.0
HFD2_k127_1596704_2 23S rRNA-intervening sequence protein - - - 0.00000000000000000000002943 104.0
HFD2_k127_1596704_3 Peptidase M56 - - - 0.0000000000000000000001201 113.0
HFD2_k127_1596704_4 SCP-2 sterol transfer family - - - 0.000000000000000000004278 98.0
HFD2_k127_1596704_5 - - - - 0.0000663 50.0
HFD2_k127_1705437_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 606.0
HFD2_k127_1705437_1 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 344.0
HFD2_k127_1705437_2 COG0493 NADPH-dependent glutamate synthase beta chain and related K00266,K17722 - 1.3.1.1,1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000009231 214.0
HFD2_k127_1705437_3 S1/P1 Nuclease - - - 0.000000000000000000000000000000000000000000000000005552 197.0
HFD2_k127_1705437_4 SnoaL-like domain K03088 - - 0.00000000000000000000000000000000000000000001112 166.0
HFD2_k127_17247_0 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007352 274.0
HFD2_k127_17247_1 transposition, DNA-mediated - - - 0.000000000000000003269 88.0
HFD2_k127_17247_2 transposition, DNA-mediated - - - 0.0001104 48.0
HFD2_k127_1773918_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 573.0
HFD2_k127_1867148_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 6.528e-272 880.0
HFD2_k127_1867148_1 CarboxypepD_reg-like domain - - - 1.364e-262 846.0
HFD2_k127_1867148_10 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 524.0
HFD2_k127_1867148_11 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 520.0
HFD2_k127_1867148_12 Sodium:dicarboxylate symporter family K11102 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 478.0
HFD2_k127_1867148_13 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 490.0
HFD2_k127_1867148_14 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 458.0
HFD2_k127_1867148_15 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 466.0
HFD2_k127_1867148_16 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 392.0
HFD2_k127_1867148_17 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 388.0
HFD2_k127_1867148_18 Rieske-like [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 400.0
HFD2_k127_1867148_19 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 383.0
HFD2_k127_1867148_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 9.253e-253 797.0
HFD2_k127_1867148_20 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 362.0
HFD2_k127_1867148_21 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000419 354.0
HFD2_k127_1867148_22 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009317 339.0
HFD2_k127_1867148_23 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 315.0
HFD2_k127_1867148_24 SusD family K21572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 317.0
HFD2_k127_1867148_25 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 286.0
HFD2_k127_1867148_26 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004159 295.0
HFD2_k127_1867148_27 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001852 293.0
HFD2_k127_1867148_28 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005581 280.0
HFD2_k127_1867148_3 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.607e-237 743.0
HFD2_k127_1867148_30 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000001486 265.0
HFD2_k127_1867148_31 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000004906 271.0
HFD2_k127_1867148_32 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004607 265.0
HFD2_k127_1867148_33 of the major facilitator superfamily K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002864 253.0
HFD2_k127_1867148_34 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 0.000000000000000000000000000000000000000000000000000000000000000000006026 248.0
HFD2_k127_1867148_35 metal-dependent phosphohydrolase, HD sub domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000009302 236.0
HFD2_k127_1867148_36 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000001261 222.0
HFD2_k127_1867148_37 protease with the C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000002819 236.0
HFD2_k127_1867148_38 sulfuric ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000006981 240.0
HFD2_k127_1867148_39 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000166 232.0
HFD2_k127_1867148_4 Penicillin amidase K01434 - 3.5.1.11 7.643e-224 726.0
HFD2_k127_1867148_40 - - - - 0.000000000000000000000000000000000000000000000000000000000008218 238.0
HFD2_k127_1867148_41 Conserved protein domain typically associated with flavoprotein oxygenases DIM6 NTAB family - - - 0.00000000000000000000000000000000000000000000000000000000001026 218.0
HFD2_k127_1867148_42 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000003465 201.0
HFD2_k127_1867148_43 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000009237 205.0
HFD2_k127_1867148_44 Phosphoesterase family K01114 - 3.1.4.3 0.000000000000000000000000000000000000000000000000000005345 208.0
HFD2_k127_1867148_45 sugar phosphatases of the HAD superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000245 194.0
HFD2_k127_1867148_46 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000003424 199.0
HFD2_k127_1867148_47 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000468 193.0
HFD2_k127_1867148_48 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000004965 199.0
HFD2_k127_1867148_49 curli production assembly transport component CsgG K04087 - - 0.000000000000000000000000000000000000000000000006006 190.0
HFD2_k127_1867148_5 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.406e-220 706.0
HFD2_k127_1867148_50 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000006989 189.0
HFD2_k127_1867148_51 - - - - 0.000000000000000000000000000000000000000000004544 181.0
HFD2_k127_1867148_52 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000007103 166.0
HFD2_k127_1867148_53 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000004247 154.0
HFD2_k127_1867148_54 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000001151 149.0
HFD2_k127_1867148_55 MobA-like NTP transferase domain K07281 - 2.7.7.74 0.000000000000000000000000000000001806 143.0
HFD2_k127_1867148_56 - - - - 0.00000000000000000000000000000003034 145.0
HFD2_k127_1867148_57 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000003841 142.0
HFD2_k127_1867148_58 Nucleotidyl transferase - - - 0.00000000000000000000000000000005287 142.0
HFD2_k127_1867148_59 DinB family - - - 0.0000000000000000000000000000009649 128.0
HFD2_k127_1867148_6 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 1.085e-211 686.0
HFD2_k127_1867148_60 Protein of unknown function, DUF393 - - - 0.000000000000000000000000000007146 123.0
HFD2_k127_1867148_61 - - - - 0.000000000000000000000000000008087 123.0
HFD2_k127_1867148_62 Cold shock protein K03704 - - 0.00000000000000000000000000001263 118.0
HFD2_k127_1867148_63 MerR HTH family regulatory protein - - - 0.00000000000000000000000000002686 129.0
HFD2_k127_1867148_64 endonuclease activity - - - 0.0000000000000000000000000001268 120.0
HFD2_k127_1867148_65 PFAM Rhodanese-like domain - - - 0.00000000000000000000000003994 116.0
HFD2_k127_1867148_66 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000001256 113.0
HFD2_k127_1867148_67 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000003347 117.0
HFD2_k127_1867148_68 - - - - 0.0000000000000000000001586 108.0
HFD2_k127_1867148_69 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000318 109.0
HFD2_k127_1867148_7 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 623.0
HFD2_k127_1867148_70 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000378 108.0
HFD2_k127_1867148_71 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000005767 108.0
HFD2_k127_1867148_72 DinB family - - - 0.000000000000000000142 104.0
HFD2_k127_1867148_73 lactoylglutathione lyase activity - - - 0.0000000000000000002499 93.0
HFD2_k127_1867148_74 - - - - 0.000000000000000000633 96.0
HFD2_k127_1867148_75 Methyltransferase domain - - - 0.000000000000000008599 97.0
HFD2_k127_1867148_76 GyrI-like small molecule binding domain - - - 0.000000000000002845 83.0
HFD2_k127_1867148_77 - - - - 0.00000000000003116 85.0
HFD2_k127_1867148_78 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.000000000000781 77.0
HFD2_k127_1867148_79 - - - - 0.00000000003322 72.0
HFD2_k127_1867148_8 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 607.0
HFD2_k127_1867148_80 histidine kinase A domain protein K02482 - 2.7.13.3 0.00000000008833 74.0
HFD2_k127_1867148_81 alpha/beta hydrolase fold - - - 0.0000000006108 70.0
HFD2_k127_1867148_82 YceI-like domain - - - 0.000000002083 68.0
HFD2_k127_1867148_83 - K20478 - - 0.000000002804 71.0
HFD2_k127_1867148_85 - - - - 0.0000005788 60.0
HFD2_k127_1867148_86 Ornithine decarboxylase inhibitor-putative sigma54 transciptional regulator K02584 - - 0.000002192 58.0
HFD2_k127_1867148_87 Copper binding proteins, plastocyanin/azurin family - - - 0.000002814 55.0
HFD2_k127_1867148_9 Nitrite and sulphite reductase 4Fe-4S domain K00392 - 1.8.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 559.0
HFD2_k127_1867148_90 - - - - 0.00009894 49.0
HFD2_k127_1867148_91 Cupredoxin-like domain - - - 0.0002317 53.0
HFD2_k127_1867148_92 GDSL-like Lipase/Acylhydrolase - - - 0.0009439 51.0
HFD2_k127_1876700_0 efflux transmembrane transporter activity - - - 1.598e-267 843.0
HFD2_k127_1876700_1 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 510.0
HFD2_k127_1876700_10 - - - - 0.000002317 55.0
HFD2_k127_1876700_12 Putative zinc-finger - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00001449 54.0
HFD2_k127_1876700_2 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 488.0
HFD2_k127_1876700_3 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 373.0
HFD2_k127_1876700_4 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 306.0
HFD2_k127_1876700_5 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002693 258.0
HFD2_k127_1876700_6 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000002454 227.0
HFD2_k127_1876700_7 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000000005203 186.0
HFD2_k127_1876700_8 DUF218 domain - - - 0.000000000000000000000000000000000000000001295 165.0
HFD2_k127_1876700_9 Redoxin - - - 0.000000000000000000000000000000000000000003624 163.0
HFD2_k127_194680_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1173.0
HFD2_k127_194680_1 MacB-like periplasmic core domain - - - 0.0 1063.0
HFD2_k127_194680_10 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 7.527e-219 691.0
HFD2_k127_194680_100 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000000001194 172.0
HFD2_k127_194680_101 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000657 187.0
HFD2_k127_194680_102 - - - - 0.00000000000000000000000000000000000000000001265 166.0
HFD2_k127_194680_103 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000001578 168.0
HFD2_k127_194680_104 Ham1 family K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000206 171.0
HFD2_k127_194680_105 Cupredoxin-like domain - - - 0.00000000000000000000000000000000000000000005135 164.0
HFD2_k127_194680_106 PFAM Class II aldolase adducin K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000003442 169.0
HFD2_k127_194680_107 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000003631 169.0
HFD2_k127_194680_108 Transcriptional regulator - - - 0.000000000000000000000000000000000000000008129 160.0
HFD2_k127_194680_109 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000000000000000000001365 157.0
HFD2_k127_194680_11 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.419e-209 683.0
HFD2_k127_194680_110 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000002587 156.0
HFD2_k127_194680_111 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.00000000000000000000000000000000000000004807 173.0
HFD2_k127_194680_112 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000004431 147.0
HFD2_k127_194680_113 Lipopolysaccharide-assembly - - - 0.0000000000000000000000000000000000005867 146.0
HFD2_k127_194680_114 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.000000000000000000000000000000000003103 148.0
HFD2_k127_194680_115 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000003068 156.0
HFD2_k127_194680_116 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000006974 136.0
HFD2_k127_194680_117 Vitamin K epoxide reductase family - - - 0.00000000000000000000000000000000009692 147.0
HFD2_k127_194680_118 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.000000000000000000000000000000001058 144.0
HFD2_k127_194680_119 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000007643 130.0
HFD2_k127_194680_12 Participates in both transcription termination and antitermination K02600 - - 1.867e-200 638.0
HFD2_k127_194680_120 Cytochrome c - - - 0.0000000000000000000000000000004177 139.0
HFD2_k127_194680_121 ferredoxin-NADP+ reductase activity - - - 0.000000000000000000000000000003742 125.0
HFD2_k127_194680_122 - - - - 0.000000000000000000000000001345 123.0
HFD2_k127_194680_123 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000027 121.0
HFD2_k127_194680_124 - - - - 0.000000000000000000000000002883 123.0
HFD2_k127_194680_125 - - - - 0.000000000000000000000000006293 124.0
HFD2_k127_194680_126 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000172 119.0
HFD2_k127_194680_127 hydrolase K21471 - - 0.000000000000000000000000166 121.0
HFD2_k127_194680_128 Ankyrin repeats (many copies) - - - 0.0000000000000000000000003846 111.0
HFD2_k127_194680_129 PTS system sorbose-specific iic component K02795 - - 0.0000000000000000000000005203 117.0
HFD2_k127_194680_13 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 578.0
HFD2_k127_194680_130 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000005293 113.0
HFD2_k127_194680_131 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.000000000000000000000002568 114.0
HFD2_k127_194680_132 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000006102 108.0
HFD2_k127_194680_133 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000007123 114.0
HFD2_k127_194680_134 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000001981 106.0
HFD2_k127_194680_135 PTS HPr component phosphorylation site K11189 - - 0.00000000000000000001201 106.0
HFD2_k127_194680_136 - - - - 0.00000000000000000003365 97.0
HFD2_k127_194680_137 protein secretion K21449 - - 0.00000000000000000005722 96.0
HFD2_k127_194680_138 PTS system fructose IIA component K02744 - - 0.00000000000000000008318 94.0
HFD2_k127_194680_139 Regulatory protein, FmdB family - - - 0.000000000000000002027 92.0
HFD2_k127_194680_14 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 582.0
HFD2_k127_194680_140 Cytochrome c - - - 0.00000000000000006038 91.0
HFD2_k127_194680_141 Zinc finger domain - - - 0.0000000000000004269 90.0
HFD2_k127_194680_142 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000004468 88.0
HFD2_k127_194680_143 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.0000000000002157 74.0
HFD2_k127_194680_144 Heavy-metal-associated domain K07213 - - 0.0000000000005787 73.0
HFD2_k127_194680_147 PFAM blue (type 1) copper domain protein - - - 0.000000000004589 78.0
HFD2_k127_194680_148 - - - - 0.000000000005257 78.0
HFD2_k127_194680_149 Histidine kinase - - - 0.000000000006412 74.0
HFD2_k127_194680_15 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 570.0
HFD2_k127_194680_150 protein conserved in bacteria K09764 - - 0.00000000003209 68.0
HFD2_k127_194680_151 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000007678 66.0
HFD2_k127_194680_152 - - - - 0.000000000583 71.0
HFD2_k127_194680_153 4Fe-4S binding domain - - - 0.00000001672 60.0
HFD2_k127_194680_154 Roadblock/LC7 domain K07131 - - 0.00000005405 59.0
HFD2_k127_194680_155 sequence-specific DNA binding K20480 - - 0.0000001368 61.0
HFD2_k127_194680_156 PFAM Late competence development protein ComFB K02241 - - 0.0000001407 60.0
HFD2_k127_194680_157 transcriptional regulator K02167 - - 0.000001544 57.0
HFD2_k127_194680_158 Fic/DOC family K07341 - - 0.000006792 48.0
HFD2_k127_194680_159 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.00000768 53.0
HFD2_k127_194680_16 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 555.0
HFD2_k127_194680_160 - - - - 0.00001984 53.0
HFD2_k127_194680_161 - - - - 0.00006235 53.0
HFD2_k127_194680_163 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000191 50.0
HFD2_k127_194680_17 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 535.0
HFD2_k127_194680_18 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 516.0
HFD2_k127_194680_19 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 533.0
HFD2_k127_194680_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 2.282e-309 954.0
HFD2_k127_194680_20 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 504.0
HFD2_k127_194680_21 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 497.0
HFD2_k127_194680_22 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 499.0
HFD2_k127_194680_23 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 496.0
HFD2_k127_194680_24 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 490.0
HFD2_k127_194680_25 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 489.0
HFD2_k127_194680_26 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 486.0
HFD2_k127_194680_27 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 507.0
HFD2_k127_194680_28 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 476.0
HFD2_k127_194680_29 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 465.0
HFD2_k127_194680_3 Heavy-metal-associated domain K01533,K17686 - 3.6.3.4,3.6.3.54 2.147e-303 957.0
HFD2_k127_194680_30 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 448.0
HFD2_k127_194680_31 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 453.0
HFD2_k127_194680_32 Glycosyl transferase 4-like K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 438.0
HFD2_k127_194680_33 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 432.0
HFD2_k127_194680_34 Proton-conducting membrane transporter K12137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 455.0
HFD2_k127_194680_35 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008049 426.0
HFD2_k127_194680_36 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 424.0
HFD2_k127_194680_37 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 426.0
HFD2_k127_194680_38 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 414.0
HFD2_k127_194680_39 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 416.0
HFD2_k127_194680_4 LVIVD repeat - - - 1.655e-279 874.0
HFD2_k127_194680_40 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 417.0
HFD2_k127_194680_41 Elongation factor SelB winged helix 3 K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 417.0
HFD2_k127_194680_42 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 409.0
HFD2_k127_194680_43 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 413.0
HFD2_k127_194680_44 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 391.0
HFD2_k127_194680_45 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 382.0
HFD2_k127_194680_46 pfkB family carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 376.0
HFD2_k127_194680_47 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 383.0
HFD2_k127_194680_48 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007387 393.0
HFD2_k127_194680_49 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 372.0
HFD2_k127_194680_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.592e-278 865.0
HFD2_k127_194680_50 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 359.0
HFD2_k127_194680_51 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 343.0
HFD2_k127_194680_52 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 338.0
HFD2_k127_194680_53 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 336.0
HFD2_k127_194680_54 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 332.0
HFD2_k127_194680_55 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 326.0
HFD2_k127_194680_56 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 319.0
HFD2_k127_194680_57 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 342.0
HFD2_k127_194680_58 Nucleotidyl transferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 309.0
HFD2_k127_194680_59 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 302.0
HFD2_k127_194680_6 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 2.491e-234 741.0
HFD2_k127_194680_60 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 316.0
HFD2_k127_194680_61 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 292.0
HFD2_k127_194680_62 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 288.0
HFD2_k127_194680_63 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 293.0
HFD2_k127_194680_64 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001064 293.0
HFD2_k127_194680_65 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003878 292.0
HFD2_k127_194680_66 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000003705 274.0
HFD2_k127_194680_67 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K04040,K20616 - 2.5.1.133,2.5.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000005285 278.0
HFD2_k127_194680_68 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007038 284.0
HFD2_k127_194680_69 ADP-ribosylglycohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003234 266.0
HFD2_k127_194680_7 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.165e-227 728.0
HFD2_k127_194680_70 ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000329 254.0
HFD2_k127_194680_71 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000004605 236.0
HFD2_k127_194680_72 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000005998 233.0
HFD2_k127_194680_73 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000001311 246.0
HFD2_k127_194680_74 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000001439 231.0
HFD2_k127_194680_75 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000002779 244.0
HFD2_k127_194680_76 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001087 236.0
HFD2_k127_194680_77 S4 RNA-binding domain K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000002075 231.0
HFD2_k127_194680_78 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000007774 228.0
HFD2_k127_194680_79 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000008107 228.0
HFD2_k127_194680_8 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 1.718e-226 714.0
HFD2_k127_194680_80 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000238 229.0
HFD2_k127_194680_81 heme binding - - - 0.00000000000000000000000000000000000000000000000000000000000008725 231.0
HFD2_k127_194680_82 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000005196 220.0
HFD2_k127_194680_83 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000001065 214.0
HFD2_k127_194680_84 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000001064 211.0
HFD2_k127_194680_85 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000001161 220.0
HFD2_k127_194680_86 hydrogenase 4 membrane K12140 - - 0.000000000000000000000000000000000000000000000000000000001292 207.0
HFD2_k127_194680_87 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000000000000000002067 211.0
HFD2_k127_194680_88 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000006516 210.0
HFD2_k127_194680_89 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000001577 201.0
HFD2_k127_194680_9 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.434e-223 706.0
HFD2_k127_194680_90 - - - - 0.00000000000000000000000000000000000000000000000000004047 198.0
HFD2_k127_194680_91 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000005599 193.0
HFD2_k127_194680_92 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000001879 187.0
HFD2_k127_194680_93 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.0000000000000000000000000000000000000000000000008876 179.0
HFD2_k127_194680_94 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000001784 186.0
HFD2_k127_194680_95 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000006746 190.0
HFD2_k127_194680_96 Ferric reductase like transmembrane component - - - 0.00000000000000000000000000000000000000000000002021 178.0
HFD2_k127_194680_97 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000001673 181.0
HFD2_k127_194680_98 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000007265 170.0
HFD2_k127_194680_99 PTS system sorbose subfamily IIB component K19507 - - 0.0000000000000000000000000000000000000000000009601 175.0
HFD2_k127_2059415_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.172e-227 737.0
HFD2_k127_2059415_1 peptidase S9 prolyl oligopeptidase active site K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009735 488.0
HFD2_k127_2059415_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 421.0
HFD2_k127_2059415_3 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 394.0
HFD2_k127_2059415_4 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 371.0
HFD2_k127_2059415_5 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000003023 172.0
HFD2_k127_2059415_6 PFAM membrane protein of K08972 - - 0.0000000000000000000000000001964 119.0
HFD2_k127_2059415_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000004903 121.0
HFD2_k127_2110279_0 transmembrane transporter activity K03296 - - 1.575e-256 831.0
HFD2_k127_2110279_1 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 5.811e-239 766.0
HFD2_k127_2110279_10 efflux transmembrane transporter activity K15725 - - 0.0000000000000000000000000000000000000001682 168.0
HFD2_k127_2110279_11 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000000000000000000000000000007143 152.0
HFD2_k127_2110279_12 PFAM transposase mutator type K07493 - - 0.00000000000000000000000003385 108.0
HFD2_k127_2110279_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000004121 65.0
HFD2_k127_2110279_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 453.0
HFD2_k127_2110279_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004862 408.0
HFD2_k127_2110279_4 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 369.0
HFD2_k127_2110279_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 301.0
HFD2_k127_2110279_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000004763 263.0
HFD2_k127_2110279_7 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000005703 256.0
HFD2_k127_2110279_8 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000003121 163.0
HFD2_k127_2110279_9 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000001145 167.0
HFD2_k127_2151602_0 recombinase activity K03601,K13582 - 3.1.11.6 1.531e-251 796.0
HFD2_k127_2151602_1 Transposase DDE domain - - - 0.0000001316 53.0
HFD2_k127_2151602_2 COG3385 FOG Transposase and inactivated derivatives - - - 0.0009684 46.0
HFD2_k127_2272317_0 ACT domain K12524 - 1.1.1.3,2.7.2.4 2.316e-278 880.0
HFD2_k127_2272317_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 563.0
HFD2_k127_2272317_2 PFAM Alanine dehydrogenase PNT, C-terminal domain K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 396.0
HFD2_k127_2272317_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009378 309.0
HFD2_k127_2272317_4 Uncharacterized protein conserved in bacteria (DUF2062) - - - 0.000000000000000000000000000000000006878 142.0
HFD2_k127_2272317_5 NAD(P)+ transhydrogenase (AB-specific) activity K00324 - 1.6.1.2 0.000000000000000000002169 109.0
HFD2_k127_2272317_6 Protein involved in outer membrane biogenesis - - - 0.000000000000000000006372 108.0
HFD2_k127_2272317_7 FMN binding - - - 0.000000000000003681 85.0
HFD2_k127_2272317_8 Domain of unknown function (DUF4412) - - - 0.00000000000007641 80.0
HFD2_k127_228076_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1146.0
HFD2_k127_228076_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.0 1035.0
HFD2_k127_228076_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 332.0
HFD2_k127_228076_11 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 327.0
HFD2_k127_228076_12 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008983 321.0
HFD2_k127_228076_13 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 300.0
HFD2_k127_228076_14 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 294.0
HFD2_k127_228076_15 Lytic transglycosylase catalytic K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004331 299.0
HFD2_k127_228076_16 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003682 276.0
HFD2_k127_228076_17 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002026 261.0
HFD2_k127_228076_18 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000002889 259.0
HFD2_k127_228076_19 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002226 258.0
HFD2_k127_228076_2 ABC transporter transmembrane region K18890 - - 1.482e-208 668.0
HFD2_k127_228076_20 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000085 250.0
HFD2_k127_228076_21 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000004343 247.0
HFD2_k127_228076_22 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000005508 231.0
HFD2_k127_228076_23 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000005702 230.0
HFD2_k127_228076_24 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000009719 199.0
HFD2_k127_228076_25 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000007812 193.0
HFD2_k127_228076_26 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000003192 182.0
HFD2_k127_228076_27 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000000000000000002848 171.0
HFD2_k127_228076_28 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000005868 157.0
HFD2_k127_228076_29 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000002231 145.0
HFD2_k127_228076_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 578.0
HFD2_k127_228076_30 of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000007645 148.0
HFD2_k127_228076_31 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000001591 121.0
HFD2_k127_228076_32 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000001401 108.0
HFD2_k127_228076_33 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000001703 98.0
HFD2_k127_228076_34 integral membrane protein K07027 - - 0.0000000000000000002097 100.0
HFD2_k127_228076_35 FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits K01990,K21397 - - 0.0000000000000001946 93.0
HFD2_k127_228076_36 cystathionine gamma-synthase activity K01739,K01740,K01760,K01761,K10764 - 2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8 0.0000000000005498 69.0
HFD2_k127_228076_37 ArsR family transcriptional regulator - - - 0.0000000004252 68.0
HFD2_k127_228076_38 - - - - 0.0000000004339 66.0
HFD2_k127_228076_39 - - - - 0.0000009244 56.0
HFD2_k127_228076_4 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 422.0
HFD2_k127_228076_40 protein import K06867 - - 0.000001094 59.0
HFD2_k127_228076_41 - - - - 0.0005997 43.0
HFD2_k127_228076_5 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 419.0
HFD2_k127_228076_6 aminopeptidase K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 417.0
HFD2_k127_228076_7 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 382.0
HFD2_k127_228076_8 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 375.0
HFD2_k127_228076_9 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 344.0
HFD2_k127_24467_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000003725 59.0
HFD2_k127_24467_1 - - - - 0.0007487 45.0
HFD2_k127_2493774_0 heme-copper terminal oxidase activity K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 621.0
HFD2_k127_2493774_1 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002043 258.0
HFD2_k127_2493774_10 2 iron, 2 sulfur cluster binding K13643 - - 0.00000000000000000000001407 106.0
HFD2_k127_2493774_11 MltA-interacting protein MipA - - - 0.0000000000000000000002115 103.0
HFD2_k127_2493774_12 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000001211 96.0
HFD2_k127_2493774_13 metal-sulfur cluster biosynthetic enzyme - - - 0.00000000000000000005389 94.0
HFD2_k127_2493774_14 F420H(2)-dependent quinone reductase - - - 0.000000000000000003774 95.0
HFD2_k127_2493774_15 SCO1/SenC K07152 - - 0.0000000000004942 82.0
HFD2_k127_2493774_16 Protein of unknown function (DUF2892) - - - 0.000000000219 68.0
HFD2_k127_2493774_17 CBD_II K01179 - 3.2.1.4 0.0002934 48.0
HFD2_k127_2493774_18 - - - - 0.0003041 53.0
HFD2_k127_2493774_2 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000414 247.0
HFD2_k127_2493774_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000001703 208.0
HFD2_k127_2493774_4 cytochrome c oxidase (Subunit II) - - - 0.0000000000000000000000000000000000000000000000000000004994 199.0
HFD2_k127_2493774_5 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000005856 190.0
HFD2_k127_2493774_6 Domain of unknown function (DUF1858) - - - 0.000000000000000000000000000000000000002586 169.0
HFD2_k127_2493774_7 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000000008407 151.0
HFD2_k127_2493774_8 Belongs to the heme-copper respiratory oxidase family - - - 0.00000000000000000000000000000000004845 150.0
HFD2_k127_2493774_9 Uncharacterized conserved protein (DUF2249) - - - 0.000000000000000000000000001136 114.0
HFD2_k127_257786_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1475.0
HFD2_k127_257786_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.821e-276 861.0
HFD2_k127_257786_2 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 379.0
HFD2_k127_257786_3 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005732 272.0
HFD2_k127_257786_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000001208 238.0
HFD2_k127_257786_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000003232 221.0
HFD2_k127_257786_6 peptidase S8 and S53, subtilisin, kexin, sedolisin K14645 - - 0.000000000000000000000000000000000000000000000000006714 208.0
HFD2_k127_263145_0 Bacterial regulatory protein, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000004227 228.0
HFD2_k127_263145_1 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000009689 211.0
HFD2_k127_263145_2 PFAM HlyD family secretion protein K02022 - - 0.00000000000000000000000001233 125.0
HFD2_k127_2647435_0 FeoA - - - 6.786e-292 913.0
HFD2_k127_2647435_1 Heavy metal translocating P-type atpase K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 544.0
HFD2_k127_2647435_10 Prolyl oligopeptidase family K06889 - - 0.000000000000000000000000000000000000000000000000003013 192.0
HFD2_k127_2647435_11 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000887 173.0
HFD2_k127_2647435_12 NUDIX domain - - - 0.000000000000000000000000000000000000002808 156.0
HFD2_k127_2647435_13 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000007031 115.0
HFD2_k127_2647435_14 Regulatory protein, FmdB family - - - 0.00000000001896 66.0
HFD2_k127_2647435_15 Tetratricopeptide repeat - - - 0.00003946 56.0
HFD2_k127_2647435_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 378.0
HFD2_k127_2647435_3 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002956 290.0
HFD2_k127_2647435_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002448 290.0
HFD2_k127_2647435_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004897 275.0
HFD2_k127_2647435_6 iron ion homeostasis K03322,K03709,K04758 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002372 265.0
HFD2_k127_2647435_7 Microcin C7 resistance K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000002579 259.0
HFD2_k127_2647435_8 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000003067 239.0
HFD2_k127_2647435_9 lipoprotein localization to outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000001143 222.0
HFD2_k127_2650303_0 Tricorn protease homolog K08676 - - 0.0 1426.0
HFD2_k127_2650303_1 Tricorn protease homolog K08676 - - 0.0 1387.0
HFD2_k127_2650303_10 Molybdopterin oxidoreductase K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 465.0
HFD2_k127_2650303_11 Formylmethanofuran-tetrahydromethanopterin formyltransferase K00672 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0071704 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 449.0
HFD2_k127_2650303_12 TIGRFAM formylmethanofuran dehydrogenase subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 390.0
HFD2_k127_2650303_13 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 389.0
HFD2_k127_2650303_14 Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) K00672 GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0044281,GO:0071704 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 372.0
HFD2_k127_2650303_15 C1 transfer pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 337.0
HFD2_k127_2650303_16 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0044424,GO:0044464,GO:0071704 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 334.0
HFD2_k127_2650303_17 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009561 338.0
HFD2_k127_2650303_18 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 325.0
HFD2_k127_2650303_19 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 296.0
HFD2_k127_2650303_2 Atp-dependent helicase - - - 7.84e-321 1004.0
HFD2_k127_2650303_20 PFAM Alcohol dehydrogenase, zinc-binding K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 302.0
HFD2_k127_2650303_21 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005347 282.0
HFD2_k127_2650303_22 GXGXG motif K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002695 280.0
HFD2_k127_2650303_23 PFAM Methylene-tetrahydromethanopterin dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000973 275.0
HFD2_k127_2650303_24 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000002083 267.0
HFD2_k127_2650303_25 formylmethanofuran dehydrogenase activity K00202 GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000002136 267.0
HFD2_k127_2650303_26 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001493 265.0
HFD2_k127_2650303_27 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002125 267.0
HFD2_k127_2650303_28 CO2 hydration protein (ChpXY) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009797 247.0
HFD2_k127_2650303_29 ATP:dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.0000000000000000000000000000000000000000000000000000000000000000001138 246.0
HFD2_k127_2650303_3 TIGRFAM Formylmethanofuran dehydrogenase, subunit A K00200 - 1.2.7.12 4.726e-270 842.0
HFD2_k127_2650303_30 PFAM Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000001021 230.0
HFD2_k127_2650303_31 converts alpha-aldose to the beta-anomer - - - 0.000000000000000000000000000000000000000000000001945 187.0
HFD2_k127_2650303_32 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000007222 150.0
HFD2_k127_2650303_33 usher protein - - - 0.00000000000000000000000000000000007084 155.0
HFD2_k127_2650303_35 - - - - 0.000000000000000000000000000003577 139.0
HFD2_k127_2650303_36 pilus organization K12132 - 2.7.11.1 0.0000000000000000000000001447 121.0
HFD2_k127_2650303_37 EamA-like transporter family - - - 0.000000000000000000003563 105.0
HFD2_k127_2650303_39 negative regulation of transcription, DNA-templated - - - 0.000000000000000004031 88.0
HFD2_k127_2650303_4 DNA-directed DNA polymerase K02337,K14162 - 2.7.7.7 8.396e-228 745.0
HFD2_k127_2650303_40 EthD domain - - - 0.0000000000000009027 87.0
HFD2_k127_2650303_41 EthD domain - - - 0.00000000000004503 82.0
HFD2_k127_2650303_42 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.000000000001218 74.0
HFD2_k127_2650303_43 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000128 60.0
HFD2_k127_2650303_44 PAS modulated sigma54 specific transcriptional regulator, Fis family - - - 0.000002829 55.0
HFD2_k127_2650303_45 positive regulation of type IV pilus biogenesis K07343 - - 0.0001298 49.0
HFD2_k127_2650303_5 C-terminus of AA_permease K03294 - - 5.968e-210 663.0
HFD2_k127_2650303_6 Formylmethanofuran dehydrogenase subunit A K00200 GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281 1.2.7.12 8.153e-207 672.0
HFD2_k127_2650303_7 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 517.0
HFD2_k127_2650303_8 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 532.0
HFD2_k127_2650303_9 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008057 502.0
HFD2_k127_2658597_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1433.0
HFD2_k127_2658597_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.127e-244 771.0
HFD2_k127_2658597_10 ErfK ybiS ycfS ynhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006168 243.0
HFD2_k127_2658597_11 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000002619 219.0
HFD2_k127_2658597_12 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000006258 210.0
HFD2_k127_2658597_13 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000004431 208.0
HFD2_k127_2658597_14 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000002334 190.0
HFD2_k127_2658597_15 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000005886 173.0
HFD2_k127_2658597_16 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000001239 156.0
HFD2_k127_2658597_17 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000000000007778 143.0
HFD2_k127_2658597_18 redox protein regulator of disulfide bond formation K04063 - - 0.0000000000000000000000000000000000239 140.0
HFD2_k127_2658597_19 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000001998 151.0
HFD2_k127_2658597_2 FtsX-like permease family K02004 - - 5.028e-195 649.0
HFD2_k127_2658597_20 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000005052 126.0
HFD2_k127_2658597_21 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000004646 122.0
HFD2_k127_2658597_22 Putative adhesin - - - 0.0000000000000000000009814 109.0
HFD2_k127_2658597_23 Transcriptional K07979 - - 0.00000000000000002221 87.0
HFD2_k127_2658597_24 - - - - 0.0000000000000005327 86.0
HFD2_k127_2658597_25 PFAM CBS domain K07182 - - 0.000000000000001445 81.0
HFD2_k127_2658597_27 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000000002306 66.0
HFD2_k127_2658597_28 DinB family - - - 0.0000001495 60.0
HFD2_k127_2658597_29 - - - - 0.000002395 57.0
HFD2_k127_2658597_3 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000585 512.0
HFD2_k127_2658597_30 Homocysteine K00547,K21169 - 2.1.1.10 0.0001846 49.0
HFD2_k127_2658597_4 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 442.0
HFD2_k127_2658597_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 428.0
HFD2_k127_2658597_6 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006087 327.0
HFD2_k127_2658597_7 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 317.0
HFD2_k127_2658597_8 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 292.0
HFD2_k127_2658597_9 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008797 287.0
HFD2_k127_2725058_0 B12 binding domain K00548 - 2.1.1.13 0.0 1791.0
HFD2_k127_2725058_1 C-terminal, D2-small domain, of ClpB protein K11907 - - 0.0 1195.0
HFD2_k127_2725058_10 Phage late control gene D protein (GPD) K11904 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009872 621.0
HFD2_k127_2725058_11 Pyridoxal-dependent decarboxylase conserved domain K13745 - 4.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 602.0
HFD2_k127_2725058_12 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 562.0
HFD2_k127_2725058_13 Sugar (and other) transporter K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 555.0
HFD2_k127_2725058_14 ImpA, N-terminal, type VI secretion system K11902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 569.0
HFD2_k127_2725058_15 Acts as a magnesium transporter K06213 GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 517.0
HFD2_k127_2725058_16 C4-dicarboxylate anaerobic carrier - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 506.0
HFD2_k127_2725058_17 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 465.0
HFD2_k127_2725058_18 Histidine kinase K01768,K02482,K02660,K03406,K05874,K07315,K10819,K11525,K11617 - 2.7.13.3,3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007541 460.0
HFD2_k127_2725058_19 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 441.0
HFD2_k127_2725058_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1026.0
HFD2_k127_2725058_20 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 433.0
HFD2_k127_2725058_21 radical SAM domain protein K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 424.0
HFD2_k127_2725058_22 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 426.0
HFD2_k127_2725058_23 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 380.0
HFD2_k127_2725058_24 type VI secretion protein, VC_A0111 family K11895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 356.0
HFD2_k127_2725058_25 type VI secretion protein K11900,K11901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 337.0
HFD2_k127_2725058_26 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 317.0
HFD2_k127_2725058_27 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 311.0
HFD2_k127_2725058_28 Pfam:Methyltransf_26 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 312.0
HFD2_k127_2725058_29 ImpE protein K11898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 292.0
HFD2_k127_2725058_3 ImcF-related N-terminal domain K11891 - - 9.968e-248 805.0
HFD2_k127_2725058_30 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 301.0
HFD2_k127_2725058_31 Belongs to the ABC transporter superfamily K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 292.0
HFD2_k127_2725058_32 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005107 284.0
HFD2_k127_2725058_33 chemotaxis protein K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001311 299.0
HFD2_k127_2725058_34 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002919 288.0
HFD2_k127_2725058_35 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02045,K02049,K02068,K02071,K06857,K10112,K11072 - 3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009747 291.0
HFD2_k127_2725058_36 May be involved in the transport of PQQ or its precursor to the periplasm K06136,K06167 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 276.0
HFD2_k127_2725058_37 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002991 271.0
HFD2_k127_2725058_38 Type VI secretion system, VipA, VC_A0107 or Hcp2 K11901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001478 250.0
HFD2_k127_2725058_39 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000644 239.0
HFD2_k127_2725058_4 Type VI secretion protein, EvpB/VC_A0108, tail sheath K11900 - - 1.384e-244 763.0
HFD2_k127_2725058_40 Chemotaxis sensory transducer K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000003205 246.0
HFD2_k127_2725058_41 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 GO:0003674,GO:0003824,GO:0006935,GO:0008150,GO:0008984,GO:0009605,GO:0016787,GO:0016788,GO:0040011,GO:0042221,GO:0042330,GO:0050896,GO:0051723,GO:0052689,GO:0140096 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000002268 233.0
HFD2_k127_2725058_42 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000714 225.0
HFD2_k127_2725058_43 Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000006006 226.0
HFD2_k127_2725058_44 Type VI secretion system protein DotU K11892 - - 0.0000000000000000000000000000000000000000000000000000000000164 214.0
HFD2_k127_2725058_45 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000001442 218.0
HFD2_k127_2725058_46 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000005024 206.0
HFD2_k127_2725058_47 ABC transporter K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000000000000185 202.0
HFD2_k127_2725058_48 CcmB protein K02194 - - 0.0000000000000000000000000000000000000000000000000003798 194.0
HFD2_k127_2725058_49 histone H2A K63-linked ubiquitination K11894 - - 0.000000000000000000000000000000000000000000000000001217 195.0
HFD2_k127_2725058_5 Type VI secretion system, TssF K11896 - - 3.732e-241 759.0
HFD2_k127_2725058_50 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000007312 192.0
HFD2_k127_2725058_51 Type VI secretion system effector, Hcp K11903 - - 0.0000000000000000000000000000000000000000000000001526 182.0
HFD2_k127_2725058_52 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000001689 184.0
HFD2_k127_2725058_53 PAAR motif - - - 0.000000000000000000000000000000000000000000001099 169.0
HFD2_k127_2725058_54 - - - - 0.0000000000000000000000000000000000000000008821 167.0
HFD2_k127_2725058_55 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000002863 160.0
HFD2_k127_2725058_56 Yhs domain-containing protein - - - 0.0000000000000000000000000000000000000004907 153.0
HFD2_k127_2725058_57 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000001678 159.0
HFD2_k127_2725058_58 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000003318 158.0
HFD2_k127_2725058_59 TIGRFAM Type VI secretion system, lysozyme-related K11897 - - 0.00000000000000000000000000000001618 134.0
HFD2_k127_2725058_6 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 1.013e-235 746.0
HFD2_k127_2725058_60 YGGT family K02221 - - 0.0000000000000000000000000000006682 129.0
HFD2_k127_2725058_61 PFAM CheW domain protein K03408 - - 0.000000000000000000000000000002018 127.0
HFD2_k127_2725058_62 Vitamin K epoxide reductase family - - - 0.0000000000000000000000000003708 119.0
HFD2_k127_2725058_63 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000004778 117.0
HFD2_k127_2725058_64 water channel activity K02440,K06188,K09874 - - 0.0000000000000000000000000005937 114.0
HFD2_k127_2725058_65 Yip1 domain - - - 0.00000000000000000000000003375 118.0
HFD2_k127_2725058_66 OsmC-like protein K07397 - - 0.000000000000000000000001751 109.0
HFD2_k127_2725058_67 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000003688 102.0
HFD2_k127_2725058_68 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000003708 103.0
HFD2_k127_2725058_69 cheY-homologous receiver domain K03413 - - 0.00000000000000000001318 100.0
HFD2_k127_2725058_7 Aldehyde dehydrogenase family K00294 - 1.2.1.88 9.076e-226 715.0
HFD2_k127_2725058_70 Acid phosphatase homologues - - - 0.00000000000000000006035 100.0
HFD2_k127_2725058_71 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.0000000000000000004306 91.0
HFD2_k127_2725058_73 - - - - 0.0000000000000002962 82.0
HFD2_k127_2725058_74 cheY-homologous receiver domain K03413 - - 0.000000000000002394 81.0
HFD2_k127_2725058_75 pyrroloquinoline quinone biosynthesis protein D K06138 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.00000000000000425 80.0
HFD2_k127_2725058_76 molybdate ion transport K02019 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000001387 79.0
HFD2_k127_2725058_77 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000002058 74.0
HFD2_k127_2725058_78 - - - - 0.00000000001202 78.0
HFD2_k127_2725058_8 Transport of potassium into the cell K03549 - - 4.044e-223 712.0
HFD2_k127_2725058_81 PFAM Phosphate-selective porin O K07221 - - 0.00000002914 65.0
HFD2_k127_2725058_82 involved in lipopolysaccharide synthesis - - - 0.000003391 56.0
HFD2_k127_2725058_83 deoxyhypusine monooxygenase activity K05384 - - 0.00001814 58.0
HFD2_k127_2725058_85 ABC transporter, phosphonate, periplasmic substrate-binding protein K02020 - - 0.0001424 52.0
HFD2_k127_2725058_9 Insulinase (Peptidase family M16) K07263 - - 5.418e-201 657.0
HFD2_k127_2831290_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 325.0
HFD2_k127_2831290_1 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000009997 210.0
HFD2_k127_2831290_3 Bacterial regulatory proteins, tetR family - - - 0.00002366 51.0
HFD2_k127_2831290_4 lysine biosynthetic process via aminoadipic acid - - - 0.0000924 48.0
HFD2_k127_2846516_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1072.0
HFD2_k127_2846516_1 efflux transmembrane transporter activity - - - 9.531e-276 874.0
HFD2_k127_2846516_10 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000001945 175.0
HFD2_k127_2846516_11 Thioesterase-like superfamily - - - 0.0000000000000000000000000000005864 129.0
HFD2_k127_2846516_12 GYD domain - - - 0.0000000000000000000000000001536 119.0
HFD2_k127_2846516_13 Predicted membrane protein (DUF2127) - - - 0.0000000000000000000000002831 112.0
HFD2_k127_2846516_14 methyltransferase activity - - - 0.00000000000000000000003855 104.0
HFD2_k127_2846516_15 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000002272 104.0
HFD2_k127_2846516_16 Transcription factor zinc-finger K09981 - - 0.00000000000000001838 85.0
HFD2_k127_2846516_17 DinB family - - - 0.0000000000000004423 86.0
HFD2_k127_2846516_19 Protein of unknown function (DUF2905) - - - 0.00000000000009192 74.0
HFD2_k127_2846516_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.868e-262 831.0
HFD2_k127_2846516_20 beta-galactosidase activity - - - 0.00005258 49.0
HFD2_k127_2846516_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 555.0
HFD2_k127_2846516_4 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 389.0
HFD2_k127_2846516_5 amine dehydrogenase activity K17285 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 389.0
HFD2_k127_2846516_6 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 335.0
HFD2_k127_2846516_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 320.0
HFD2_k127_2846516_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001148 284.0
HFD2_k127_2846516_9 Alpha/beta hydrolase family K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000009766 231.0
HFD2_k127_2860290_0 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000001641 150.0
HFD2_k127_2860290_1 transposition, DNA-mediated K02342 - 2.7.7.7 0.0000000000000000000000000000000002989 144.0
HFD2_k127_286442_0 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000001998 217.0
HFD2_k127_286442_2 synthase - - - 0.0007935 53.0
HFD2_k127_2868476_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 6.958e-265 830.0
HFD2_k127_2868476_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 599.0
HFD2_k127_2868476_10 Protein of unknown function (DUF721) - - - 0.000000000000000002013 90.0
HFD2_k127_2868476_11 peptidyl-tyrosine sulfation - - - 0.000000000000002371 86.0
HFD2_k127_2868476_2 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 509.0
HFD2_k127_2868476_3 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 346.0
HFD2_k127_2868476_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 334.0
HFD2_k127_2868476_5 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 298.0
HFD2_k127_2868476_6 SAM (And some other nucleotide) binding motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001141 266.0
HFD2_k127_2868476_7 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000004709 232.0
HFD2_k127_2868476_8 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000002527 232.0
HFD2_k127_2868476_9 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000002257 200.0
HFD2_k127_2892284_0 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 323.0
HFD2_k127_2892284_1 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000002694 101.0
HFD2_k127_2908699_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 4.2e-255 800.0
HFD2_k127_2908699_1 Alpha-glucosidase K01187,K21574 - 3.2.1.20,3.2.1.3 6.518e-229 758.0
HFD2_k127_2908699_2 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000002316 275.0
HFD2_k127_2959558_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 6.261e-207 657.0
HFD2_k127_2959558_1 PglZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 616.0
HFD2_k127_2959558_10 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 459.0
HFD2_k127_2959558_11 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 447.0
HFD2_k127_2959558_12 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 436.0
HFD2_k127_2959558_13 Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 397.0
HFD2_k127_2959558_14 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 403.0
HFD2_k127_2959558_15 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 378.0
HFD2_k127_2959558_16 4Fe-4S binding domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 369.0
HFD2_k127_2959558_17 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 354.0
HFD2_k127_2959558_18 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 357.0
HFD2_k127_2959558_19 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 327.0
HFD2_k127_2959558_2 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 587.0
HFD2_k127_2959558_20 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 320.0
HFD2_k127_2959558_21 Thiazole biosynthesis protein ThiG K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 308.0
HFD2_k127_2959558_22 Cytochrome c K07243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 329.0
HFD2_k127_2959558_23 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 310.0
HFD2_k127_2959558_24 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 309.0
HFD2_k127_2959558_25 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 298.0
HFD2_k127_2959558_26 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002614 295.0
HFD2_k127_2959558_27 Ethanolamine ammonia-lyase light chain (EutC) K03736 - 4.3.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000422 280.0
HFD2_k127_2959558_28 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000043 259.0
HFD2_k127_2959558_29 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000005477 254.0
HFD2_k127_2959558_3 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 537.0
HFD2_k127_2959558_30 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000003912 252.0
HFD2_k127_2959558_31 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001628 236.0
HFD2_k127_2959558_32 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000196 223.0
HFD2_k127_2959558_33 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000002941 233.0
HFD2_k127_2959558_34 PFAM glycosyl transferase family 9 K02843 - - 0.0000000000000000000000000000000000000000000000000000002616 207.0
HFD2_k127_2959558_35 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000001685 207.0
HFD2_k127_2959558_36 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000001093 190.0
HFD2_k127_2959558_37 DnaB-like helicase C terminal domain K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000005054 194.0
HFD2_k127_2959558_38 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000006518 178.0
HFD2_k127_2959558_39 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000003184 171.0
HFD2_k127_2959558_4 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009062 531.0
HFD2_k127_2959558_40 AntiSigma factor - - - 0.00000000000000000000000000000000000000000001396 177.0
HFD2_k127_2959558_41 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000002403 169.0
HFD2_k127_2959558_42 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000004268 163.0
HFD2_k127_2959558_43 lipid kinase activity - - - 0.0000000000000000000000000000000000000000167 176.0
HFD2_k127_2959558_44 NlpC/P60 family - - - 0.00000000000000000000000000000000000000003581 163.0
HFD2_k127_2959558_45 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.00000000000000000000000000000000000000007464 165.0
HFD2_k127_2959558_46 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000009365 153.0
HFD2_k127_2959558_47 Glutathione peroxidase - - - 0.00000000000000000000000000000000000001018 162.0
HFD2_k127_2959558_48 PFAM FAD binding domain K11472 - - 0.0000000000000000000000000000000000001342 157.0
HFD2_k127_2959558_49 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000007167 151.0
HFD2_k127_2959558_5 COG0493 NADPH-dependent glutamate synthase beta chain and related K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 511.0
HFD2_k127_2959558_50 ArsR family transcriptional regulator - - - 0.00000000000000000000000000000000306 135.0
HFD2_k127_2959558_51 ATP-dependent protease La (LON) substrate-binding domain K01338 - 3.4.21.53 0.0000000000000000000000000000001011 132.0
HFD2_k127_2959558_52 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.000000000000000000000000000102 128.0
HFD2_k127_2959558_53 CYTH domain K01768,K05873 - 4.6.1.1 0.0000000000000000000000000001193 123.0
HFD2_k127_2959558_54 Psort location Cytoplasmic, score K00945 - 2.7.4.25 0.000000000000000000000000000528 122.0
HFD2_k127_2959558_55 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000003123 108.0
HFD2_k127_2959558_56 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000009428 106.0
HFD2_k127_2959558_57 - - - - 0.000000000000000000004379 101.0
HFD2_k127_2959558_58 Preprotein translocase subunit K03210 - - 0.0000000000000000006438 91.0
HFD2_k127_2959558_59 PASTA K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000002319 96.0
HFD2_k127_2959558_6 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 507.0
HFD2_k127_2959558_60 DinB family - - - 0.0000000000000001479 88.0
HFD2_k127_2959558_61 Thiamine biosynthesis protein ThiS K03154 - - 0.000000000000001047 80.0
HFD2_k127_2959558_62 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000002061 82.0
HFD2_k127_2959558_63 DinB superfamily - - - 0.0000003906 55.0
HFD2_k127_2959558_64 transposase IS116 IS110 IS902 family K07486 - - 0.00006547 45.0
HFD2_k127_2959558_7 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 497.0
HFD2_k127_2959558_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 475.0
HFD2_k127_2959558_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 447.0
HFD2_k127_3047397_0 PFAM FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 316.0
HFD2_k127_3047397_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000001314 222.0
HFD2_k127_3047397_2 ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000004975 212.0
HFD2_k127_3047397_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000009985 154.0
HFD2_k127_3047397_4 Belongs to the GcvT family K00605 - 2.1.2.10 0.000000000001708 70.0
HFD2_k127_3047397_5 PFAM blue (type 1) copper domain protein - - - 0.0004643 48.0
HFD2_k127_3189773_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 547.0
HFD2_k127_3189773_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 450.0
HFD2_k127_3189773_10 ArsC family - - - 0.000000000000000000000000000000000000000002179 158.0
HFD2_k127_3189773_11 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000002602 144.0
HFD2_k127_3189773_12 Cell division protein FtsQ K03589 - - 0.000000000000000000000000004084 119.0
HFD2_k127_3189773_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 440.0
HFD2_k127_3189773_3 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 428.0
HFD2_k127_3189773_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 413.0
HFD2_k127_3189773_5 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 413.0
HFD2_k127_3189773_6 Cell cycle protein K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 298.0
HFD2_k127_3189773_7 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003377 293.0
HFD2_k127_3189773_8 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001703 286.0
HFD2_k127_3189773_9 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001199 233.0
HFD2_k127_320019_0 RNA polymerase binding - - - 3.052e-291 967.0
HFD2_k127_320019_1 Peptidase family M28 - - - 3.885e-256 799.0
HFD2_k127_320019_10 PAS domain K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 392.0
HFD2_k127_320019_11 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 351.0
HFD2_k127_320019_12 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 342.0
HFD2_k127_320019_13 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006774 318.0
HFD2_k127_320019_14 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 295.0
HFD2_k127_320019_15 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001476 289.0
HFD2_k127_320019_16 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004039 289.0
HFD2_k127_320019_17 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004178 281.0
HFD2_k127_320019_18 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001392 278.0
HFD2_k127_320019_19 Dienelactone hydrolase family K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009081 244.0
HFD2_k127_320019_2 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 8.245e-250 782.0
HFD2_k127_320019_20 Peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000009956 209.0
HFD2_k127_320019_21 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000005289 203.0
HFD2_k127_320019_22 - - - - 0.000000000000000000000000000000000000000000671 163.0
HFD2_k127_320019_23 Thioredoxin-like domain K03672 - 1.8.1.8 0.000000000000000000000000000000000000009872 151.0
HFD2_k127_320019_24 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000006052 162.0
HFD2_k127_320019_25 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K22110 - - 0.000000000000000000000000000000001758 140.0
HFD2_k127_320019_26 S4 RNA-binding domain K04762 - - 0.00000000000000000000000000000001471 132.0
HFD2_k127_320019_27 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000001639 137.0
HFD2_k127_320019_29 GIY-YIG catalytic domain protein K07461 - - 0.00000000000000000004806 102.0
HFD2_k127_320019_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.221e-197 645.0
HFD2_k127_320019_30 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000003983 85.0
HFD2_k127_320019_31 Competence protein ComEA K02237 - - 0.00000000000006125 81.0
HFD2_k127_320019_32 protein kinase activity - - - 0.00000000006344 68.0
HFD2_k127_320019_33 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.0000000002618 61.0
HFD2_k127_320019_34 sequence-specific DNA binding - - - 0.00003746 53.0
HFD2_k127_320019_4 Bacterial regulatory protein, Fis family - - - 3.206e-195 622.0
HFD2_k127_320019_5 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 585.0
HFD2_k127_320019_6 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 584.0
HFD2_k127_320019_7 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 528.0
HFD2_k127_320019_8 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 454.0
HFD2_k127_320019_9 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 428.0
HFD2_k127_3259400_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 597.0
HFD2_k127_3259400_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 544.0
HFD2_k127_3259400_10 PFAM binding-protein-dependent transport systems inner membrane component K02046,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 392.0
HFD2_k127_3259400_11 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000778 392.0
HFD2_k127_3259400_12 PFAM Mo-co oxidoreductase dimerisation domain K00387 - 1.8.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 364.0
HFD2_k127_3259400_13 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 346.0
HFD2_k127_3259400_14 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 327.0
HFD2_k127_3259400_15 Membrane-bound serine protease (ClpP class) K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 301.0
HFD2_k127_3259400_16 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000005274 244.0
HFD2_k127_3259400_17 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000001149 231.0
HFD2_k127_3259400_18 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000003356 233.0
HFD2_k127_3259400_19 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000002965 229.0
HFD2_k127_3259400_2 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 527.0
HFD2_k127_3259400_20 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000002263 209.0
HFD2_k127_3259400_21 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000000000002374 210.0
HFD2_k127_3259400_22 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000005449 175.0
HFD2_k127_3259400_23 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000008432 166.0
HFD2_k127_3259400_24 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000003215 159.0
HFD2_k127_3259400_25 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000001152 170.0
HFD2_k127_3259400_26 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000556 143.0
HFD2_k127_3259400_27 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000001193 154.0
HFD2_k127_3259400_28 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000001965 150.0
HFD2_k127_3259400_29 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000005996 139.0
HFD2_k127_3259400_3 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 500.0
HFD2_k127_3259400_30 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000007551 122.0
HFD2_k127_3259400_31 Phosphoribosyl transferase domain - - - 0.0000000000000000001971 93.0
HFD2_k127_3259400_32 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.00000000000000009077 83.0
HFD2_k127_3259400_33 TonB-dependent Receptor Plug Domain - - - 0.000000000000001578 91.0
HFD2_k127_3259400_34 - - - - 0.000000000003483 73.0
HFD2_k127_3259400_35 Uncharacterized small protein (DUF2292) - - - 0.000000009078 57.0
HFD2_k127_3259400_36 - - - - 0.0007338 47.0
HFD2_k127_3259400_4 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 497.0
HFD2_k127_3259400_5 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 474.0
HFD2_k127_3259400_6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 434.0
HFD2_k127_3259400_7 UPF0365 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 413.0
HFD2_k127_3259400_8 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 408.0
HFD2_k127_3259400_9 sulfate ABC transporter K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 412.0
HFD2_k127_3272455_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1287.0
HFD2_k127_3272455_1 Amidohydrolase family - - - 0.0 1197.0
HFD2_k127_3272455_10 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 366.0
HFD2_k127_3272455_11 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 354.0
HFD2_k127_3272455_12 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 336.0
HFD2_k127_3272455_13 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006603 298.0
HFD2_k127_3272455_14 Modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001895 293.0
HFD2_k127_3272455_15 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009034 277.0
HFD2_k127_3272455_16 PFAM regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006225 281.0
HFD2_k127_3272455_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001222 282.0
HFD2_k127_3272455_18 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001267 271.0
HFD2_k127_3272455_19 Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000697 275.0
HFD2_k127_3272455_2 COG0433 Predicted ATPase K06915 - - 1.969e-255 802.0
HFD2_k127_3272455_20 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000006374 267.0
HFD2_k127_3272455_21 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001639 250.0
HFD2_k127_3272455_22 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000003274 242.0
HFD2_k127_3272455_23 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000001254 203.0
HFD2_k127_3272455_24 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000001748 196.0
HFD2_k127_3272455_25 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000001047 191.0
HFD2_k127_3272455_26 KR domain - - - 0.000000000000000000000000000000000000000000000000002336 198.0
HFD2_k127_3272455_27 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000001583 185.0
HFD2_k127_3272455_28 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000001512 176.0
HFD2_k127_3272455_29 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000004727 173.0
HFD2_k127_3272455_3 AMP-binding enzyme K01897 - 6.2.1.3 9.277e-197 636.0
HFD2_k127_3272455_30 Phosphoribosyl transferase domain K07101 - - 0.000000000000000000000000000000000000000000000717 173.0
HFD2_k127_3272455_31 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000007139 185.0
HFD2_k127_3272455_32 Phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000005537 171.0
HFD2_k127_3272455_33 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.0000000000000000000000000000000000000003761 159.0
HFD2_k127_3272455_34 AI-2E family transporter - - - 0.0000000000000000000000000000000000000007549 164.0
HFD2_k127_3272455_35 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000000005827 151.0
HFD2_k127_3272455_36 COGs COG2380 conserved - - - 0.000000000000000000000000000000000001605 151.0
HFD2_k127_3272455_37 Peptidase M56, BlaR1 - - - 0.000000000000000000000000000001386 138.0
HFD2_k127_3272455_38 DbpA RNA binding domain K05592 - 3.6.4.13 0.000000000000000000000000000004639 135.0
HFD2_k127_3272455_39 Penicillinase repressor - - - 0.00000000000000000000000000001835 126.0
HFD2_k127_3272455_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.601e-195 632.0
HFD2_k127_3272455_40 Histidine kinase - - - 0.0000000000000000000000001862 116.0
HFD2_k127_3272455_41 - - - - 0.0000000000000000000000004136 113.0
HFD2_k127_3272455_42 sensor histidine kinase response - - - 0.000000000000000000003267 104.0
HFD2_k127_3272455_43 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000007995 88.0
HFD2_k127_3272455_44 Peptidase, M23 family - - - 0.00000000000002219 87.0
HFD2_k127_3272455_45 Oligoendopeptidase f - - - 0.0000006462 62.0
HFD2_k127_3272455_46 V4R K07013 - - 0.000001146 58.0
HFD2_k127_3272455_47 nitrilase K01501,K13035 GO:0000257,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009683,GO:0009684,GO:0009850,GO:0009851,GO:0009987,GO:0010035,GO:0010038,GO:0010817,GO:0016020,GO:0016053,GO:0016787,GO:0016810,GO:0016815,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0018822,GO:0019438,GO:0019752,GO:0032787,GO:0034641,GO:0034754,GO:0042221,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0043436,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046686,GO:0050896,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0072330,GO:0080061,GO:0080109,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.5.1,3.5.5.4,4.2.1.65 0.0002689 46.0
HFD2_k127_3272455_5 AAA domain K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 588.0
HFD2_k127_3272455_6 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 557.0
HFD2_k127_3272455_7 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 536.0
HFD2_k127_3272455_8 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 377.0
HFD2_k127_3272455_9 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 370.0
HFD2_k127_3291681_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 6.66e-238 751.0
HFD2_k127_3291681_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.577e-214 679.0
HFD2_k127_3291681_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 532.0
HFD2_k127_3291681_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000003119 150.0
HFD2_k127_3419062_0 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 413.0
HFD2_k127_3419062_1 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 350.0
HFD2_k127_3419062_10 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000002041 234.0
HFD2_k127_3419062_11 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000005118 229.0
HFD2_k127_3419062_12 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000000000000000007918 230.0
HFD2_k127_3419062_13 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000001404 239.0
HFD2_k127_3419062_14 Protein of unknown function (DUF1348) K09958 - - 0.000000000000000000000000000000000000000000000000000000000000001517 220.0
HFD2_k127_3419062_15 DinB family - - - 0.000000000000000000000000000000000000000000000000000000003388 208.0
HFD2_k127_3419062_16 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000004521 204.0
HFD2_k127_3419062_17 Serine hydrolase K07002,K19073 - 1.3.1.75 0.000000000000000000000000000000000000000000000000000000009981 205.0
HFD2_k127_3419062_18 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000002285 191.0
HFD2_k127_3419062_19 Protein of unknown function (DUF3224) - - - 0.0000000000000000000000000000000000000000000000000307 185.0
HFD2_k127_3419062_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 302.0
HFD2_k127_3419062_20 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000001156 183.0
HFD2_k127_3419062_21 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000001487 175.0
HFD2_k127_3419062_22 - - - - 0.000000000000000000000000000000000000000000000001754 180.0
HFD2_k127_3419062_23 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000003498 175.0
HFD2_k127_3419062_24 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000000000000001953 181.0
HFD2_k127_3419062_25 acetyltransferase K18816 - 2.3.1.82 0.00000000000000000000000000000000000000000000025 171.0
HFD2_k127_3419062_26 DinB family - - - 0.0000000000000000000000000000000000000000000005356 171.0
HFD2_k127_3419062_27 - - - - 0.000000000000000000000000000000000000000000002232 170.0
HFD2_k127_3419062_28 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000000000000003066 162.0
HFD2_k127_3419062_29 acetyltransferase - - - 0.000000000000000000000000000000000000000001067 162.0
HFD2_k127_3419062_3 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 294.0
HFD2_k127_3419062_30 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.000000000000000000000000000000000000000002475 160.0
HFD2_k127_3419062_31 DinB superfamily - - - 0.000000000000000000000000000000000000000003116 160.0
HFD2_k127_3419062_32 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.000000000000000000000000000000000000000008433 157.0
HFD2_k127_3419062_33 YhhN family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000009528 150.0
HFD2_k127_3419062_34 methyltransferase activity - - - 0.00000000000000000000000000000000006824 151.0
HFD2_k127_3419062_35 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000191 135.0
HFD2_k127_3419062_36 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.00000000000000000000000002858 118.0
HFD2_k127_3419062_37 thiolester hydrolase activity - - - 0.00000000000000000000000003857 111.0
HFD2_k127_3419062_38 - - - - 0.0000000000000000000001661 102.0
HFD2_k127_3419062_39 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000844 98.0
HFD2_k127_3419062_4 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 293.0
HFD2_k127_3419062_40 - - - - 0.000000000000000000009139 100.0
HFD2_k127_3419062_41 Protein of unknown function (DUF1097) - - - 0.0000000000000000008591 93.0
HFD2_k127_3419062_43 Alkylmercury lyase - - - 0.00000000000000009056 87.0
HFD2_k127_3419062_44 - - - - 0.0000000000001278 78.0
HFD2_k127_3419062_45 - - - - 0.00000000003732 66.0
HFD2_k127_3419062_46 DsrE/DsrF-like family - - - 0.00000000009454 68.0
HFD2_k127_3419062_47 Protein of unknown function (DUF2380) - - - 0.0000000002483 68.0
HFD2_k127_3419062_48 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000003064 60.0
HFD2_k127_3419062_49 - - - - 0.000000003794 65.0
HFD2_k127_3419062_5 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008997 271.0
HFD2_k127_3419062_50 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000004589 64.0
HFD2_k127_3419062_52 Ankyrin repeat - - - 0.00000001867 63.0
HFD2_k127_3419062_53 Alkylmercury lyase - - - 0.0000004489 54.0
HFD2_k127_3419062_55 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000359 49.0
HFD2_k127_3419062_56 - - - - 0.0004689 51.0
HFD2_k127_3419062_58 Protein of unknown function (DUF2380) - - - 0.0007542 50.0
HFD2_k127_3419062_6 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004455 282.0
HFD2_k127_3419062_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005123 261.0
HFD2_k127_3419062_8 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001341 247.0
HFD2_k127_3419062_9 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005889 240.0
HFD2_k127_3515262_0 decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 467.0
HFD2_k127_3515262_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 440.0
HFD2_k127_3515262_2 - - - - 0.00000000000000000000000000000000000000008417 154.0
HFD2_k127_3515262_3 5-carboxymethyl-2-hydroxymuconate isomerase - - - 0.000000000000000004025 89.0
HFD2_k127_3515262_4 - - - - 0.00000001409 63.0
HFD2_k127_3525140_0 serine-type peptidase activity K08676 - - 0.0 1278.0
HFD2_k127_3525140_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 6.478e-316 987.0
HFD2_k127_3525140_10 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 328.0
HFD2_k127_3525140_11 Cache domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009013 281.0
HFD2_k127_3525140_12 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000136 262.0
HFD2_k127_3525140_13 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000001575 220.0
HFD2_k127_3525140_14 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000000000000000000000000511 214.0
HFD2_k127_3525140_15 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000003761 193.0
HFD2_k127_3525140_16 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000008889 193.0
HFD2_k127_3525140_17 - - - - 0.000000000000000000000000000000000002363 150.0
HFD2_k127_3525140_18 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000007558 116.0
HFD2_k127_3525140_19 - - - - 0.000000000002174 74.0
HFD2_k127_3525140_2 esterase - - - 3.817e-252 792.0
HFD2_k127_3525140_20 PFAM SH3, type 3 - - - 0.00000000006539 73.0
HFD2_k127_3525140_21 Membrane - - - 0.000007325 57.0
HFD2_k127_3525140_22 alcohol dehydrogenase K00344 - 1.6.5.5 0.0003196 46.0
HFD2_k127_3525140_3 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 8.013e-243 763.0
HFD2_k127_3525140_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 569.0
HFD2_k127_3525140_5 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 556.0
HFD2_k127_3525140_6 Nucleoside H+ symporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 471.0
HFD2_k127_3525140_7 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 448.0
HFD2_k127_3525140_8 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 389.0
HFD2_k127_3525140_9 aminopeptidase K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 364.0
HFD2_k127_3546238_0 Large extracellular alpha-helical protein K06894 - - 0.0 2196.0
HFD2_k127_3546238_1 penicillin binding K05367 - 2.4.1.129 8.997e-251 795.0
HFD2_k127_3546238_2 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 535.0
HFD2_k127_3546238_3 Arginosuccinate synthase K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 431.0
HFD2_k127_3546238_4 oxidoreductases (related to aryl-alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 426.0
HFD2_k127_3546238_5 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 290.0
HFD2_k127_3546238_6 PFAM M42 glutamyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003883 280.0
HFD2_k127_3546238_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002176 257.0
HFD2_k127_3546238_8 SMART Transcription regulator, AsnC-type K03718,K03719 - - 0.000000000000000000000000000000000000000001938 164.0
HFD2_k127_3546238_9 peptidase M42 family protein - - - 0.0008566 51.0
HFD2_k127_3546895_0 aminopeptidase N - - - 1.412e-244 781.0
HFD2_k127_3546895_1 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 557.0
HFD2_k127_3546895_2 PFAM Rieske 2Fe-2S domain protein K00479,K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 435.0
HFD2_k127_3546895_3 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008964 336.0
HFD2_k127_3546895_4 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005823 267.0
HFD2_k127_3546895_5 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000578 145.0
HFD2_k127_3548888_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1094.0
HFD2_k127_3548888_1 protein kinase activity - - - 3.487e-295 930.0
HFD2_k127_3548888_10 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000000000000000002033 196.0
HFD2_k127_3548888_11 zinc-ribbon domain - - - 0.000000000000000000000000000000000000448 148.0
HFD2_k127_3548888_12 - - - - 0.000000000000000000000000000000003085 131.0
HFD2_k127_3548888_14 cyclic nucleotide binding K07058,K14266 - 1.14.19.9 0.00000000000000000000000001007 117.0
HFD2_k127_3548888_15 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000006341 110.0
HFD2_k127_3548888_16 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000149 88.0
HFD2_k127_3548888_17 competence protein - - - 0.0000000000004052 74.0
HFD2_k127_3548888_18 Belongs to the UPF0337 (CsbD) family - - - 0.0000000001711 62.0
HFD2_k127_3548888_19 magnesium-translocating P-type ATPase K01531 - 3.6.3.2 0.000000002269 63.0
HFD2_k127_3548888_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.245e-276 856.0
HFD2_k127_3548888_20 peptidyl-tyrosine sulfation - - - 0.000001025 62.0
HFD2_k127_3548888_3 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 516.0
HFD2_k127_3548888_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 485.0
HFD2_k127_3548888_5 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 479.0
HFD2_k127_3548888_6 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 365.0
HFD2_k127_3548888_7 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 369.0
HFD2_k127_3548888_8 TIGRFAM Na H antiporter, bacterial form K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 328.0
HFD2_k127_3548888_9 Lysylphosphatidylglycerol synthase TM region - - - 0.0000000000000000000000000000000000000000000000000000000007382 213.0
HFD2_k127_3549944_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1123.0
HFD2_k127_3549944_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 1.152e-210 668.0
HFD2_k127_3549944_10 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000979 364.0
HFD2_k127_3549944_11 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 356.0
HFD2_k127_3549944_12 alpha,alpha-trehalase activity K01194,K03931 GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 365.0
HFD2_k127_3549944_13 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 322.0
HFD2_k127_3549944_14 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 309.0
HFD2_k127_3549944_15 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 314.0
HFD2_k127_3549944_16 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 323.0
HFD2_k127_3549944_17 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 306.0
HFD2_k127_3549944_18 phosphorelay signal transduction system K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 303.0
HFD2_k127_3549944_19 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005285 254.0
HFD2_k127_3549944_2 protein kinase activity - - - 3.988e-201 664.0
HFD2_k127_3549944_20 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006762 246.0
HFD2_k127_3549944_21 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000009471 246.0
HFD2_k127_3549944_22 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000006187 248.0
HFD2_k127_3549944_23 PFAM binding-protein-dependent transport systems inner membrane component K02025,K17242 - - 0.00000000000000000000000000000000000000000000000000000000000000000006945 258.0
HFD2_k127_3549944_24 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000008403 209.0
HFD2_k127_3549944_25 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000000000000000163 167.0
HFD2_k127_3549944_26 Putative lumazine-binding - - - 0.000000000000000000000000000000000000000002228 161.0
HFD2_k127_3549944_27 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000001291 162.0
HFD2_k127_3549944_28 Tetratricopeptide repeat K08309 - - 0.000000000000000000000000000000000000001341 168.0
HFD2_k127_3549944_29 Iron-sulphur cluster biosynthesis - - - 0.000000000000000000000000000000000000001547 151.0
HFD2_k127_3549944_3 PFAM Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008323 507.0
HFD2_k127_3549944_30 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.00000000000000000000000000000004081 136.0
HFD2_k127_3549944_31 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000002018 123.0
HFD2_k127_3549944_32 Biopolymer transport protein ExbD/TolR K03560 - - 0.00000000000000000000000000002736 122.0
HFD2_k127_3549944_33 - - - - 0.0000000000000000000005295 107.0
HFD2_k127_3549944_34 - - - - 0.0000000000000003634 82.0
HFD2_k127_3549944_35 DnaJ molecular chaperone homology domain - - - 0.0000000000002454 82.0
HFD2_k127_3549944_36 Putative zinc-binding metallo-peptidase - - - 0.000002286 60.0
HFD2_k127_3549944_37 transposase IS116 IS110 IS902 family K07486 - - 0.00006547 45.0
HFD2_k127_3549944_4 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 464.0
HFD2_k127_3549944_5 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 442.0
HFD2_k127_3549944_6 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 415.0
HFD2_k127_3549944_7 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 414.0
HFD2_k127_3549944_8 Histidine kinase K02668,K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 408.0
HFD2_k127_3549944_9 PFAM Amylo-alpha-16-glucosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 389.0
HFD2_k127_3559812_0 homoserine kinase activity K02204 - 2.7.1.39 0.0 1354.0
HFD2_k127_3559812_1 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1076.0
HFD2_k127_3559812_10 Surface antigen K07277 - - 5.482e-215 694.0
HFD2_k127_3559812_100 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000002649 177.0
HFD2_k127_3559812_101 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.000000000000000000000000000000000000000000004496 167.0
HFD2_k127_3559812_102 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000003162 175.0
HFD2_k127_3559812_103 UvrB/uvrC motif K19411 - - 0.00000000000000000000000000000000000000000004532 167.0
HFD2_k127_3559812_104 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000005367 168.0
HFD2_k127_3559812_105 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000001481 166.0
HFD2_k127_3559812_106 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000001686 171.0
HFD2_k127_3559812_107 Uncharacterised protein family (UPF0182) K09118 - - 0.000000000000000000000000000000000000001326 170.0
HFD2_k127_3559812_108 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000000000005901 160.0
HFD2_k127_3559812_109 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000006317 156.0
HFD2_k127_3559812_11 Peptidase family M1 domain - - - 1.584e-214 689.0
HFD2_k127_3559812_110 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000007907 147.0
HFD2_k127_3559812_111 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000003744 140.0
HFD2_k127_3559812_112 Hexapeptide repeat of succinyl-transferase K00661 - 2.3.1.79 0.0000000000000000000000000000000006351 135.0
HFD2_k127_3559812_113 - - - - 0.000000000000000000000000000000001907 146.0
HFD2_k127_3559812_114 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000007913 135.0
HFD2_k127_3559812_115 SNARE associated Golgi protein - - - 0.000000000000000000000000000001852 134.0
HFD2_k127_3559812_116 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000001703 118.0
HFD2_k127_3559812_117 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000009676 115.0
HFD2_k127_3559812_118 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000002116 122.0
HFD2_k127_3559812_119 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000001035 109.0
HFD2_k127_3559812_12 gluconolactonase activity K01053 - 3.1.1.17 5.64e-210 666.0
HFD2_k127_3559812_120 Lipopolysaccharide-assembly, LptC-related - - - 0.00000000000000000000001159 112.0
HFD2_k127_3559812_121 Outer membrane protein (OmpH-like) K06142 - - 0.000000000000000000000119 106.0
HFD2_k127_3559812_123 Domain of unknown function (DUF4136) - - - 0.0000000000000000000002317 105.0
HFD2_k127_3559812_124 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000009013 105.0
HFD2_k127_3559812_125 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000001334 106.0
HFD2_k127_3559812_126 PFAM Pentapeptide - - - 0.000000000000000000003802 104.0
HFD2_k127_3559812_127 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000002244 97.0
HFD2_k127_3559812_128 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000003526 103.0
HFD2_k127_3559812_129 polysaccharide deacetylase - - - 0.00000000000000000054 102.0
HFD2_k127_3559812_13 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 2.547e-204 654.0
HFD2_k127_3559812_130 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000006988 93.0
HFD2_k127_3559812_131 COG NOG14600 non supervised orthologous group - - - 0.000000000000000004814 85.0
HFD2_k127_3559812_132 Trm112p-like protein K09791 - - 0.00000000000000001758 87.0
HFD2_k127_3559812_133 Preprotein translocase SecG subunit K03075 - - 0.0000000000000001048 93.0
HFD2_k127_3559812_134 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000003211 79.0
HFD2_k127_3559812_136 ThiS family K03636 - - 0.00000000000001022 82.0
HFD2_k127_3559812_137 Phosphoribosyl transferase domain - - - 0.00000000000006845 74.0
HFD2_k127_3559812_138 acylphosphatase activity K01512 - 3.6.1.7 0.00000000000009072 82.0
HFD2_k127_3559812_139 Acetyltransferase (GNAT) domain - - - 0.000000000006302 77.0
HFD2_k127_3559812_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 3.917e-198 625.0
HFD2_k127_3559812_140 Antibiotic biosynthesis monooxygenase - - - 0.00000001456 65.0
HFD2_k127_3559812_141 peptidyl-tyrosine sulfation - - - 0.000006483 59.0
HFD2_k127_3559812_142 Tetratricopeptide repeat - - - 0.0000192 55.0
HFD2_k127_3559812_143 Copper binding proteins, plastocyanin/azurin family - - - 0.0005026 49.0
HFD2_k127_3559812_145 phosphinothricin N-acetyltransferase activity K00657 - 2.3.1.57 0.000741 49.0
HFD2_k127_3559812_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 625.0
HFD2_k127_3559812_16 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 616.0
HFD2_k127_3559812_17 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 616.0
HFD2_k127_3559812_18 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 575.0
HFD2_k127_3559812_19 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 547.0
HFD2_k127_3559812_2 AcrB/AcrD/AcrF family - - - 4.136e-313 994.0
HFD2_k127_3559812_20 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 546.0
HFD2_k127_3559812_21 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 530.0
HFD2_k127_3559812_22 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 535.0
HFD2_k127_3559812_23 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 522.0
HFD2_k127_3559812_24 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 517.0
HFD2_k127_3559812_25 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 499.0
HFD2_k127_3559812_26 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 505.0
HFD2_k127_3559812_27 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 497.0
HFD2_k127_3559812_28 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 518.0
HFD2_k127_3559812_29 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 497.0
HFD2_k127_3559812_3 Belongs to the ClpA ClpB family K03696 - - 1.009e-307 965.0
HFD2_k127_3559812_30 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 482.0
HFD2_k127_3559812_31 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 477.0
HFD2_k127_3559812_32 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 478.0
HFD2_k127_3559812_33 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008575 469.0
HFD2_k127_3559812_34 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 448.0
HFD2_k127_3559812_35 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 443.0
HFD2_k127_3559812_36 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 439.0
HFD2_k127_3559812_37 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 446.0
HFD2_k127_3559812_38 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 432.0
HFD2_k127_3559812_39 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 435.0
HFD2_k127_3559812_4 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.56e-263 823.0
HFD2_k127_3559812_40 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 425.0
HFD2_k127_3559812_41 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 416.0
HFD2_k127_3559812_42 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 397.0
HFD2_k127_3559812_43 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 401.0
HFD2_k127_3559812_44 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 392.0
HFD2_k127_3559812_45 4Fe-4S binding domain K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007095 387.0
HFD2_k127_3559812_46 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 388.0
HFD2_k127_3559812_47 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 392.0
HFD2_k127_3559812_48 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 376.0
HFD2_k127_3559812_49 Cupin 2, conserved barrel domain protein K11477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 353.0
HFD2_k127_3559812_5 choline dehydrogenase activity - - - 1.716e-253 794.0
HFD2_k127_3559812_50 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 348.0
HFD2_k127_3559812_51 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 343.0
HFD2_k127_3559812_52 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 347.0
HFD2_k127_3559812_53 gluconolactonase K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 340.0
HFD2_k127_3559812_54 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009535 329.0
HFD2_k127_3559812_55 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 343.0
HFD2_k127_3559812_56 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 325.0
HFD2_k127_3559812_57 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 328.0
HFD2_k127_3559812_58 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 331.0
HFD2_k127_3559812_59 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 319.0
HFD2_k127_3559812_6 Amylo-alpha-1,6-glucosidase - - - 1.617e-250 788.0
HFD2_k127_3559812_60 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 312.0
HFD2_k127_3559812_61 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 310.0
HFD2_k127_3559812_62 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 319.0
HFD2_k127_3559812_63 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 330.0
HFD2_k127_3559812_64 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 310.0
HFD2_k127_3559812_65 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009077 310.0
HFD2_k127_3559812_66 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 305.0
HFD2_k127_3559812_67 DAHP synthetase I family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 308.0
HFD2_k127_3559812_68 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 291.0
HFD2_k127_3559812_69 PFAM Sodium calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 310.0
HFD2_k127_3559812_7 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 3.044e-231 739.0
HFD2_k127_3559812_70 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 303.0
HFD2_k127_3559812_71 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009952 302.0
HFD2_k127_3559812_72 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005704 314.0
HFD2_k127_3559812_73 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001771 291.0
HFD2_k127_3559812_74 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003795 286.0
HFD2_k127_3559812_75 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007804 280.0
HFD2_k127_3559812_76 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004054 276.0
HFD2_k127_3559812_77 Putative ABC exporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000246 288.0
HFD2_k127_3559812_78 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000002476 275.0
HFD2_k127_3559812_79 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000259 281.0
HFD2_k127_3559812_8 Nicastrin K01301 - 3.4.17.21 2.052e-224 718.0
HFD2_k127_3559812_80 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007434 265.0
HFD2_k127_3559812_81 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003268 272.0
HFD2_k127_3559812_82 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004393 276.0
HFD2_k127_3559812_83 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000167 263.0
HFD2_k127_3559812_84 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000002167 267.0
HFD2_k127_3559812_85 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000009176 248.0
HFD2_k127_3559812_86 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000005186 245.0
HFD2_k127_3559812_87 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000002911 240.0
HFD2_k127_3559812_88 Sigma-70, region 4 K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000005259 237.0
HFD2_k127_3559812_89 Bacillithiol biosynthesis BshC K22136 - - 0.000000000000000000000000000000000000000000000000000000000000163 235.0
HFD2_k127_3559812_9 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.316e-216 688.0
HFD2_k127_3559812_90 - K00241 - - 0.0000000000000000000000000000000000000000000000000000000000005171 217.0
HFD2_k127_3559812_91 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.00000000000000000000000000000000000000000000000000000000003377 210.0
HFD2_k127_3559812_92 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000005566 209.0
HFD2_k127_3559812_93 NDK K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000008089 191.0
HFD2_k127_3559812_94 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000001355 207.0
HFD2_k127_3559812_95 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000001528 201.0
HFD2_k127_3559812_96 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000003108 190.0
HFD2_k127_3559812_97 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000003362 193.0
HFD2_k127_3559812_98 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000004194 190.0
HFD2_k127_3559812_99 Surface antigen - - - 0.000000000000000000000000000000000000000000000008798 185.0
HFD2_k127_3592411_0 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000006809 206.0
HFD2_k127_3592411_1 peptidyl-tyrosine sulfation - - - 0.0007971 51.0
HFD2_k127_3678167_0 Carbohydrate family 9 binding domain-like - - - 3.067e-320 1000.0
HFD2_k127_3678167_1 Heavy metal translocating P-type atpase K01533 - 3.6.3.4 2.774e-236 751.0
HFD2_k127_3678167_10 Histidine kinase K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000005684 222.0
HFD2_k127_3678167_11 deoxyhypusine monooxygenase activity K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000003577 210.0
HFD2_k127_3678167_12 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000000000000000006473 186.0
HFD2_k127_3678167_13 Hypothetical methyltransferase - - - 0.00000000000000000000000000000000000000000001588 169.0
HFD2_k127_3678167_15 - - - - 0.0000000000000000000000000000000000000001896 158.0
HFD2_k127_3678167_16 - - - - 0.0000000000000000000000000002888 124.0
HFD2_k127_3678167_18 - - - - 0.00000000000000005763 87.0
HFD2_k127_3678167_19 Domain of unknown function (DUF4136) - - - 0.0000000000000003728 87.0
HFD2_k127_3678167_2 Glycosyl hydrolase family 57 - - - 5.665e-230 738.0
HFD2_k127_3678167_20 Bacterial regulatory proteins, tetR family - - - 0.00000000000003669 81.0
HFD2_k127_3678167_21 - - - - 0.00000000003892 69.0
HFD2_k127_3678167_22 Protein of unknown function (DUF2933) - - - 0.000000005297 62.0
HFD2_k127_3678167_23 P-type ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000002753 62.0
HFD2_k127_3678167_24 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000005409 56.0
HFD2_k127_3678167_25 Multicopper oxidase K00368 - 1.7.2.1 0.00005057 53.0
HFD2_k127_3678167_3 Anion-transporting ATPase K01551 - 3.6.3.16 2.068e-199 639.0
HFD2_k127_3678167_4 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 491.0
HFD2_k127_3678167_5 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 496.0
HFD2_k127_3678167_6 ketosteroid isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 338.0
HFD2_k127_3678167_7 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000132 272.0
HFD2_k127_3678167_8 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000992 249.0
HFD2_k127_3678167_9 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000000000000000001956 228.0
HFD2_k127_3719325_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.249e-248 782.0
HFD2_k127_3719325_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.854e-231 760.0
HFD2_k127_3719325_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 292.0
HFD2_k127_3719325_3 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003071 261.0
HFD2_k127_3719325_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000003025 156.0
HFD2_k127_3719325_5 23S rRNA-intervening sequence protein - - - 0.00000000000000000002873 95.0
HFD2_k127_3719325_6 S23 ribosomal protein - - - 0.0000000000000000003293 92.0
HFD2_k127_3719325_7 OmpA family K03286 - - 0.000000004027 69.0
HFD2_k127_3719325_8 Aerotolerance regulator N-terminal - - - 0.0000003558 63.0
HFD2_k127_3826564_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 447.0
HFD2_k127_3826564_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 305.0
HFD2_k127_3826564_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 297.0
HFD2_k127_3826564_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000004121 205.0
HFD2_k127_3826564_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000005839 208.0
HFD2_k127_3826564_5 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000408 203.0
HFD2_k127_3826564_6 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000002823 196.0
HFD2_k127_3826564_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000003656 177.0
HFD2_k127_3826564_8 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000001015 155.0
HFD2_k127_3826564_9 Ribosomal protein L36 K02919 - - 0.00000000000001092 74.0
HFD2_k127_3864124_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.28e-204 650.0
HFD2_k127_3864124_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 1.213e-202 655.0
HFD2_k127_3864124_10 lipoprotein transporter activity K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 343.0
HFD2_k127_3864124_11 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 295.0
HFD2_k127_3864124_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005123 287.0
HFD2_k127_3864124_13 Predicted Zn-dependent protease (DUF2268) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004604 270.0
HFD2_k127_3864124_14 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000374 260.0
HFD2_k127_3864124_15 Uncharacterised protein family (UPF0167) - - - 0.00000000000000000000000000000000000000000000000000000000000000608 228.0
HFD2_k127_3864124_16 - - - - 0.00000000000000000000000000000000000000000000000000000007353 205.0
HFD2_k127_3864124_17 Transcriptional regulatory protein K07659 - - 0.000000000000000000000000000000000000000000000000000001322 202.0
HFD2_k127_3864124_18 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000002156 196.0
HFD2_k127_3864124_19 Cold shock protein domain K03704 - - 0.0000000000000000000000000000000009572 133.0
HFD2_k127_3864124_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 1.268e-201 639.0
HFD2_k127_3864124_20 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000007279 134.0
HFD2_k127_3864124_21 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000007916 126.0
HFD2_k127_3864124_22 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000439 73.0
HFD2_k127_3864124_23 Outer membrane protein beta-barrel domain - - - 0.00000000008513 73.0
HFD2_k127_3864124_24 Ribosomal protein S21 K02970 - - 0.0000000006385 63.0
HFD2_k127_3864124_25 - - - - 0.000000009046 67.0
HFD2_k127_3864124_26 4-amino-4-deoxy-L-arabinose transferase activity K02277 - 1.9.3.1 0.00009676 55.0
HFD2_k127_3864124_3 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 601.0
HFD2_k127_3864124_4 FtsX-like permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 627.0
HFD2_k127_3864124_5 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 535.0
HFD2_k127_3864124_6 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 503.0
HFD2_k127_3864124_7 Radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 428.0
HFD2_k127_3864124_8 KR domain K00034 - 1.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 402.0
HFD2_k127_3864124_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 378.0
HFD2_k127_3961640_0 - - - - 0.000000000000000000000000000000000000000000000006959 179.0
HFD2_k127_3961640_1 heme oxygenase (decyclizing) activity - - - 0.0000000000000000000000000000000000005814 142.0
HFD2_k127_3961640_2 Protein of unknown function (DUF3303) - - - 0.000000000000000000000000000000182 124.0
HFD2_k127_4062726_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 5.132e-289 904.0
HFD2_k127_4062726_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.905e-252 789.0
HFD2_k127_4062726_10 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000006544 130.0
HFD2_k127_4062726_11 - - - - 0.0000000000000000000000000000002993 127.0
HFD2_k127_4062726_12 peroxiredoxin activity K03564 - 1.11.1.15 0.000000000000000000000004297 104.0
HFD2_k127_4062726_13 - - - - 0.0000006907 62.0
HFD2_k127_4062726_14 Redoxin - - - 0.000004884 52.0
HFD2_k127_4062726_2 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 572.0
HFD2_k127_4062726_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 539.0
HFD2_k127_4062726_4 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 533.0
HFD2_k127_4062726_5 Domain of unknown function (DUF3536) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 473.0
HFD2_k127_4062726_6 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 440.0
HFD2_k127_4062726_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000079 434.0
HFD2_k127_4062726_8 homoserine K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0050896,GO:0051704,GO:0051707,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000000000000000005952 197.0
HFD2_k127_4062726_9 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000000000001496 173.0
HFD2_k127_4068066_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1170.0
HFD2_k127_4068066_1 Peptidase family M3 K08602 - - 2.161e-227 718.0
HFD2_k127_4068066_10 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000002851 108.0
HFD2_k127_4068066_11 Protein of unknown function (DUF971) K03593 - - 0.000000000000000000000009985 104.0
HFD2_k127_4068066_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000001245 86.0
HFD2_k127_4068066_13 - - - - 0.000000000000000006272 92.0
HFD2_k127_4068066_14 Predicted membrane protein (DUF2339) - - - 0.0000000001292 75.0
HFD2_k127_4068066_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 439.0
HFD2_k127_4068066_3 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 447.0
HFD2_k127_4068066_4 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 419.0
HFD2_k127_4068066_5 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 399.0
HFD2_k127_4068066_6 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 304.0
HFD2_k127_4068066_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001204 280.0
HFD2_k127_4068066_8 ABC transporter K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000004504 271.0
HFD2_k127_4068066_9 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000002126 196.0
HFD2_k127_4084273_0 Ethanolamine ammonia lyase large subunit (EutB) K03735 - 4.3.1.7 4.282e-221 696.0
HFD2_k127_4084273_1 PFAM Glycoside hydrolase, family 20, catalytic core K12373 - 3.2.1.52 2.272e-219 702.0
HFD2_k127_4084273_10 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000002926 211.0
HFD2_k127_4084273_12 LysE type translocator K03329 - - 0.00000000000000000000000000000000000000000001354 169.0
HFD2_k127_4084273_13 - - - - 0.0000000000000000000000000008137 125.0
HFD2_k127_4084273_14 23S rRNA-intervening sequence protein - - - 0.000000000000000000000007145 106.0
HFD2_k127_4084273_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 546.0
HFD2_k127_4084273_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 475.0
HFD2_k127_4084273_4 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 303.0
HFD2_k127_4084273_5 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 306.0
HFD2_k127_4084273_6 metallopeptidase activity K06402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007225 267.0
HFD2_k127_4084273_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009862 280.0
HFD2_k127_4084273_8 Outer membrane protein beta-barrel family K16087,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000002728 247.0
HFD2_k127_4084273_9 glyoxalase bleomycin resistance protein dioxygenase K06991 - - 0.00000000000000000000000000000000000000000000000000000000005007 211.0
HFD2_k127_419353_0 ABC transporter, ATP-binding protein K13926 - - 6.829e-264 841.0
HFD2_k127_419353_1 filamentation induced by cAMP protein Fic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 448.0
HFD2_k127_419353_10 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000841 151.0
HFD2_k127_419353_11 - - - - 0.0000000000000000000000000000002447 126.0
HFD2_k127_419353_12 Anion-transporting ATPase - - - 0.000000000000000000000000000006469 125.0
HFD2_k127_419353_13 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000002349 117.0
HFD2_k127_419353_14 - - - - 0.0000000000000000001042 99.0
HFD2_k127_419353_15 - - - - 0.000000000000000556 81.0
HFD2_k127_419353_16 Involved in molybdopterin and thiamine biosynthesis, family 2 K22132 - - 0.000000000000003949 80.0
HFD2_k127_419353_17 PQQ-like domain - - - 0.00000000000004362 79.0
HFD2_k127_419353_18 domain protein K07004,K09955,K16915,K20276 - - 0.00000000000004677 85.0
HFD2_k127_419353_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 298.0
HFD2_k127_419353_20 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000009685 50.0
HFD2_k127_419353_21 Pyrrolo-quinoline quinone - - - 0.0002006 48.0
HFD2_k127_419353_3 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 302.0
HFD2_k127_419353_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000005287 241.0
HFD2_k127_419353_5 antisigma factor binding K04749,K04757 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000002337 233.0
HFD2_k127_419353_6 Belongs to the binding-protein-dependent transport system permease family K05832 - - 0.0000000000000000000000000000000000000000000000000000000000002562 225.0
HFD2_k127_419353_7 methylamine metabolic process K15977 - - 0.0000000000000000000000000000000000000000000000000001208 191.0
HFD2_k127_419353_8 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000002519 160.0
HFD2_k127_419353_9 AAA domain K01090 - 3.1.3.16 0.0000000000000000000000000000000000007396 146.0
HFD2_k127_4407325_0 TIGRFAM DNA polymerase III, alpha subunit K02337,K14162 - 2.7.7.7 2.209e-303 974.0
HFD2_k127_4407325_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.121e-249 781.0
HFD2_k127_4407325_10 PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 571.0
HFD2_k127_4407325_100 - - - - 0.000000000000001594 86.0
HFD2_k127_4407325_101 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00219 - 1.3.1.34 0.00000000000002944 86.0
HFD2_k127_4407325_102 MacB-like periplasmic core domain - - - 0.00000000000009718 77.0
HFD2_k127_4407325_104 - - - - 0.000000000001254 76.0
HFD2_k127_4407325_106 Ig domain protein group 1 domain protein - - - 0.0000000000191 77.0
HFD2_k127_4407325_108 Outer membrane protein beta-barrel domain - - - 0.0000000004954 70.0
HFD2_k127_4407325_109 - - - - 0.00000003183 56.0
HFD2_k127_4407325_11 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 579.0
HFD2_k127_4407325_110 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000005472 64.0
HFD2_k127_4407325_111 - - - - 0.0000002124 61.0
HFD2_k127_4407325_112 Concanavalin A-like lectin/glucanases superfamily - - - 0.000007789 49.0
HFD2_k127_4407325_113 - - - - 0.00004446 54.0
HFD2_k127_4407325_114 long-chain fatty acid transport protein - - - 0.00007561 54.0
HFD2_k127_4407325_116 Major Facilitator Superfamily - - - 0.0004185 44.0
HFD2_k127_4407325_117 - - - - 0.0005693 43.0
HFD2_k127_4407325_119 - - - - 0.0006026 52.0
HFD2_k127_4407325_12 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 582.0
HFD2_k127_4407325_13 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 558.0
HFD2_k127_4407325_14 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 535.0
HFD2_k127_4407325_15 POT family K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 533.0
HFD2_k127_4407325_16 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 498.0
HFD2_k127_4407325_17 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 492.0
HFD2_k127_4407325_18 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 475.0
HFD2_k127_4407325_19 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 494.0
HFD2_k127_4407325_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.247e-247 771.0
HFD2_k127_4407325_20 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 460.0
HFD2_k127_4407325_21 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004563 482.0
HFD2_k127_4407325_22 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009926 442.0
HFD2_k127_4407325_23 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 455.0
HFD2_k127_4407325_24 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 434.0
HFD2_k127_4407325_25 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 421.0
HFD2_k127_4407325_26 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 410.0
HFD2_k127_4407325_27 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000868 414.0
HFD2_k127_4407325_28 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 414.0
HFD2_k127_4407325_29 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 394.0
HFD2_k127_4407325_3 FtsX-like permease family K02004 - - 6.922e-239 764.0
HFD2_k127_4407325_30 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 395.0
HFD2_k127_4407325_31 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 371.0
HFD2_k127_4407325_32 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 364.0
HFD2_k127_4407325_33 peptidyl-lysine modification to peptidyl-hypusine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 363.0
HFD2_k127_4407325_34 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009128 358.0
HFD2_k127_4407325_35 oxidase, subunit K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 362.0
HFD2_k127_4407325_36 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 353.0
HFD2_k127_4407325_37 abc transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 346.0
HFD2_k127_4407325_38 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 342.0
HFD2_k127_4407325_39 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 334.0
HFD2_k127_4407325_4 Major Facilitator Superfamily - - - 8.098e-237 741.0
HFD2_k127_4407325_40 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 330.0
HFD2_k127_4407325_41 PSP1 C-terminal conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 325.0
HFD2_k127_4407325_42 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 314.0
HFD2_k127_4407325_43 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 295.0
HFD2_k127_4407325_44 histidine kinase A domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002573 302.0
HFD2_k127_4407325_45 chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005594 299.0
HFD2_k127_4407325_46 serine O-acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001129 283.0
HFD2_k127_4407325_47 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007838 293.0
HFD2_k127_4407325_48 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000268 272.0
HFD2_k127_4407325_49 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001017 280.0
HFD2_k127_4407325_5 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 2.837e-196 621.0
HFD2_k127_4407325_50 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008527 271.0
HFD2_k127_4407325_51 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000001003 282.0
HFD2_k127_4407325_52 Putative adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000183 274.0
HFD2_k127_4407325_53 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
HFD2_k127_4407325_54 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002881 268.0
HFD2_k127_4407325_55 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003921 257.0
HFD2_k127_4407325_56 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004823 261.0
HFD2_k127_4407325_57 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000282 251.0
HFD2_k127_4407325_58 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007837 253.0
HFD2_k127_4407325_59 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001215 259.0
HFD2_k127_4407325_6 tRNA synthetases class I (M) K01874 - 6.1.1.10 1.081e-195 621.0
HFD2_k127_4407325_60 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000006896 252.0
HFD2_k127_4407325_61 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000223 240.0
HFD2_k127_4407325_62 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000004387 229.0
HFD2_k127_4407325_63 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000001822 238.0
HFD2_k127_4407325_64 Appr-1'-p processing enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000437 215.0
HFD2_k127_4407325_65 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000002668 224.0
HFD2_k127_4407325_66 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000004929 222.0
HFD2_k127_4407325_67 Glycosyl transferase family 2 K08301 - - 0.0000000000000000000000000000000000000000000000000000000003179 216.0
HFD2_k127_4407325_68 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000003538 218.0
HFD2_k127_4407325_69 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000004957 213.0
HFD2_k127_4407325_7 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 631.0
HFD2_k127_4407325_70 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000006859 224.0
HFD2_k127_4407325_71 dehydratase - - - 0.000000000000000000000000000000000000000000000000000000001654 203.0
HFD2_k127_4407325_72 gamma-glutamyl-gamma-aminobutyrate hydrolase activity K07010 - - 0.00000000000000000000000000000000000000000000000000000001777 214.0
HFD2_k127_4407325_73 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000007218 203.0
HFD2_k127_4407325_74 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000001402 202.0
HFD2_k127_4407325_75 - - - - 0.000000000000000000000000000000000000000000000000000001168 200.0
HFD2_k127_4407325_76 Glycine oxidase K03153 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016043,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 0.00000000000000000000000000000000000000000000000000009221 204.0
HFD2_k127_4407325_77 GHMP kinase - - - 0.0000000000000000000000000000000000000000000000000001989 204.0
HFD2_k127_4407325_78 Acyl-transferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000005813 193.0
HFD2_k127_4407325_79 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000008668 207.0
HFD2_k127_4407325_8 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 597.0
HFD2_k127_4407325_80 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000002278 189.0
HFD2_k127_4407325_81 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000001352 181.0
HFD2_k127_4407325_82 Gram-negative porin - - - 0.000000000000000000000000000000000000000002287 170.0
HFD2_k127_4407325_83 - - - - 0.00000000000000000000000000000000000000001581 156.0
HFD2_k127_4407325_84 Peptidase family M23 - - - 0.00000000000000000000000000000000000000002513 166.0
HFD2_k127_4407325_85 NUDIX domain - - - 0.00000000000000000000000000000000000000003216 159.0
HFD2_k127_4407325_86 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000003875 158.0
HFD2_k127_4407325_87 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000007227 152.0
HFD2_k127_4407325_88 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000000002565 134.0
HFD2_k127_4407325_89 Helix-turn-helix domain - - - 0.0000000000000000000000000000003243 136.0
HFD2_k127_4407325_9 PFAM Pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008072 568.0
HFD2_k127_4407325_90 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000368 123.0
HFD2_k127_4407325_91 DinB family - - - 0.000000000000000000000000001136 124.0
HFD2_k127_4407325_92 nucleotidyltransferase activity - - - 0.00000000000000000000000000557 119.0
HFD2_k127_4407325_93 FtsX-like permease family - - - 0.000000000000000000000000007003 127.0
HFD2_k127_4407325_94 efflux transmembrane transporter activity - - - 0.0000000000000000000000001567 119.0
HFD2_k127_4407325_95 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000009689 103.0
HFD2_k127_4407325_96 TPM domain K06872 - - 0.0000000000000000000001044 109.0
HFD2_k127_4407325_97 - - - - 0.00000000000000000002015 99.0
HFD2_k127_4407325_98 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000005705 94.0
HFD2_k127_4407325_99 - - - - 0.00000000000000008517 87.0
HFD2_k127_4415671_0 Pfam:KaiC K08482 - - 3.875e-203 647.0
HFD2_k127_4415671_1 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 464.0
HFD2_k127_4415671_10 KaiB domain K08481 - - 0.00000000000000000000000000000000125 143.0
HFD2_k127_4415671_11 - - - - 0.0000000000000000000000002959 110.0
HFD2_k127_4415671_12 OmpA family K03640 - - 0.000000000000000000000008065 113.0
HFD2_k127_4415671_13 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000002022 106.0
HFD2_k127_4415671_14 CsbD-like - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000002497 86.0
HFD2_k127_4415671_16 - - - - 0.000004433 51.0
HFD2_k127_4415671_17 23S rRNA-intervening sequence protein - - - 0.000007103 54.0
HFD2_k127_4415671_2 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 340.0
HFD2_k127_4415671_3 4Fe-4S single cluster domain K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 332.0
HFD2_k127_4415671_4 Histidine kinase K07683 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000005314 247.0
HFD2_k127_4415671_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006008 242.0
HFD2_k127_4415671_6 response regulator K07782 - - 0.0000000000000000000000000000000000000000000000000000000000000002946 228.0
HFD2_k127_4415671_7 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000002709 226.0
HFD2_k127_4415671_8 PFAM Response regulator receiver domain - - - 0.00000000000000000000000000000000000000000000000002212 194.0
HFD2_k127_4415671_9 Glycosyl transferases group 1 K13668 - 2.4.1.346 0.00000000000000000000000000000000000000000000002543 181.0
HFD2_k127_4446531_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 2.87e-281 899.0
HFD2_k127_4446531_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.841e-279 872.0
HFD2_k127_4446531_10 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000005349 209.0
HFD2_k127_4446531_11 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000001616 207.0
HFD2_k127_4446531_12 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000003578 179.0
HFD2_k127_4446531_13 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000001121 159.0
HFD2_k127_4446531_14 - - - - 0.0000000000000000000000000000000000002458 144.0
HFD2_k127_4446531_15 Two component regulator propeller - - - 0.000000000000000000000000000000006204 147.0
HFD2_k127_4446531_16 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000926 134.0
HFD2_k127_4446531_17 - - - - 0.0000000000000000000000000001125 115.0
HFD2_k127_4446531_18 PFAM BioY protein K03523 - - 0.000000000000000000000000000843 122.0
HFD2_k127_4446531_19 Sulfotransferase family, cytosolic, 1C, member 2 K01016,K01025 GO:0003674,GO:0003824,GO:0004062,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009987,GO:0016740,GO:0016782,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050427,GO:0051923,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 2.8.2.4 0.0000000000000000000000003981 120.0
HFD2_k127_4446531_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 609.0
HFD2_k127_4446531_20 Septum formation initiator K05589 - - 0.000000000222 69.0
HFD2_k127_4446531_21 hyperosmotic response - - - 0.0008582 48.0
HFD2_k127_4446531_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 546.0
HFD2_k127_4446531_4 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 520.0
HFD2_k127_4446531_5 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008132 456.0
HFD2_k127_4446531_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 406.0
HFD2_k127_4446531_7 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002972 273.0
HFD2_k127_4446531_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001774 270.0
HFD2_k127_4446531_9 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000003186 214.0
HFD2_k127_4478195_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 6.617e-210 675.0
HFD2_k127_4478195_1 Trehalase K01194 - 3.2.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 368.0
HFD2_k127_4478195_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000002492 257.0
HFD2_k127_4478195_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000003412 247.0
HFD2_k127_4478195_4 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000005749 213.0
HFD2_k127_4478195_5 - - - - 0.000000002573 64.0
HFD2_k127_4496109_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1285.0
HFD2_k127_4496109_1 nitrous-oxide reductase activity K00376,K02275 GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 1.735e-316 980.0
HFD2_k127_4496109_10 Serine dehydratase alpha chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 395.0
HFD2_k127_4496109_11 alginic acid biosynthetic process K07218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 384.0
HFD2_k127_4496109_12 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 370.0
HFD2_k127_4496109_13 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 343.0
HFD2_k127_4496109_14 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 342.0
HFD2_k127_4496109_15 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 331.0
HFD2_k127_4496109_16 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 312.0
HFD2_k127_4496109_17 COG0348 Polyferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 310.0
HFD2_k127_4496109_18 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 294.0
HFD2_k127_4496109_19 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004619 283.0
HFD2_k127_4496109_2 Belongs to the heme-copper respiratory oxidase family K00404,K15862 - 1.9.3.1 7.793e-212 668.0
HFD2_k127_4496109_20 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006566 272.0
HFD2_k127_4496109_21 Helix-hairpin-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002791 272.0
HFD2_k127_4496109_22 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004784 265.0
HFD2_k127_4496109_23 Belongs to the heme-copper respiratory oxidase family K15862 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000009548 261.0
HFD2_k127_4496109_24 Serine dehydratase beta chain K01752 - 4.3.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000001118 254.0
HFD2_k127_4496109_25 mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000007454 246.0
HFD2_k127_4496109_26 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000001225 240.0
HFD2_k127_4496109_27 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.00000000000000000000000000000000000000000000000000000000000000003253 245.0
HFD2_k127_4496109_28 nitrous oxide K19341 - - 0.0000000000000000000000000000000000000000000000000000000000005419 229.0
HFD2_k127_4496109_29 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000009276 207.0
HFD2_k127_4496109_3 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 635.0
HFD2_k127_4496109_30 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000000000000000000000000000000000000000000000001205 212.0
HFD2_k127_4496109_31 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000001492 213.0
HFD2_k127_4496109_32 Belongs to the HpcH HpaI aldolase family K00979,K01630,K02510 - 2.7.7.38,4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000000000014 205.0
HFD2_k127_4496109_33 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000001534 196.0
HFD2_k127_4496109_34 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000004195 202.0
HFD2_k127_4496109_35 PFAM Cold-shock protein, DNA-binding - - - 0.0000000000000000000000000000000000000001193 159.0
HFD2_k127_4496109_36 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000001803 144.0
HFD2_k127_4496109_37 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.000000000000000000000000000000000002377 150.0
HFD2_k127_4496109_38 - - - - 0.000000000000000000000000000000000004239 140.0
HFD2_k127_4496109_39 cytochrome C - - - 0.00000000000000000000000000000000001768 141.0
HFD2_k127_4496109_4 DNA polymerase beta thumb K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 587.0
HFD2_k127_4496109_40 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000000000000000000000000000007783 149.0
HFD2_k127_4496109_41 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000004061 138.0
HFD2_k127_4496109_42 Transcriptional regulator - - - 0.0000000000000000000000000000116 122.0
HFD2_k127_4496109_43 Domain of unknown function DUF302 - - - 0.00000000000000000000000000004703 128.0
HFD2_k127_4496109_44 CHAD domain - - - 0.00000000000000000000000001848 123.0
HFD2_k127_4496109_45 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000001389 112.0
HFD2_k127_4496109_46 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000002961 111.0
HFD2_k127_4496109_47 Protein of unknown function (DUF983) - - - 0.000000000000000000000003372 108.0
HFD2_k127_4496109_48 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000001542 106.0
HFD2_k127_4496109_49 Ribosomal protein L33 K02913 - - 0.0000000000000000000008915 94.0
HFD2_k127_4496109_5 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 506.0
HFD2_k127_4496109_50 NosL K19342 - - 0.000000000000000000004689 100.0
HFD2_k127_4496109_51 - - - - 0.00000000000000000001953 97.0
HFD2_k127_4496109_52 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000001033 95.0
HFD2_k127_4496109_53 - - - - 0.00000000000000005197 93.0
HFD2_k127_4496109_54 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000782 89.0
HFD2_k127_4496109_55 Belongs to the ompA family - - - 0.000000000001296 74.0
HFD2_k127_4496109_56 glucose sorbosone - - - 0.000000000002267 78.0
HFD2_k127_4496109_57 PFAM CBS domain K07182 - - 0.00000000003723 72.0
HFD2_k127_4496109_58 PFAM Archease protein family (DUF101 UPF0211) - - - 0.00000000006251 72.0
HFD2_k127_4496109_59 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000001023 69.0
HFD2_k127_4496109_6 E1-E2 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 510.0
HFD2_k127_4496109_60 - - - - 0.000000002154 68.0
HFD2_k127_4496109_62 Cytochrome oxidase maturation protein - - - 0.0000006053 55.0
HFD2_k127_4496109_63 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000007199 51.0
HFD2_k127_4496109_64 - - - - 0.0009325 46.0
HFD2_k127_4496109_7 DALR_2 K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 458.0
HFD2_k127_4496109_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 427.0
HFD2_k127_4496109_9 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 405.0
HFD2_k127_449779_0 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 510.0
HFD2_k127_449779_1 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 321.0
HFD2_k127_449779_2 transporter K07238,K11021,K16267 - - 0.0000000000000000000000000000000000000000000000000000000000007909 220.0
HFD2_k127_449779_3 PFAM transposase mutator type K07493 - - 0.00000000002526 64.0
HFD2_k127_4509174_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1220.0
HFD2_k127_4509174_1 UDP binding domain K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 584.0
HFD2_k127_4509174_10 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000008867 208.0
HFD2_k127_4509174_11 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000003786 213.0
HFD2_k127_4509174_12 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000044 194.0
HFD2_k127_4509174_13 - - - - 0.0000000000000000000000000000000000000000000000001359 188.0
HFD2_k127_4509174_14 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000001188 172.0
HFD2_k127_4509174_15 Outer membrane lipoprotein K05807 - - 0.0000000000000000000000000000000000000000005249 173.0
HFD2_k127_4509174_16 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000002516 136.0
HFD2_k127_4509174_17 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000002028 130.0
HFD2_k127_4509174_18 peptidyl-tyrosine sulfation - - - 0.00000000006302 72.0
HFD2_k127_4509174_2 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 501.0
HFD2_k127_4509174_3 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 449.0
HFD2_k127_4509174_4 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 385.0
HFD2_k127_4509174_5 NAD dependent epimerase dehydratase family K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 308.0
HFD2_k127_4509174_6 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002054 281.0
HFD2_k127_4509174_7 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000008089 240.0
HFD2_k127_4509174_8 protein serine/threonine kinase activity K07198 - 2.7.11.11 0.00000000000000000000000000000000000000000000000000000000000000000001139 242.0
HFD2_k127_4509174_9 PFAM transferase hexapeptide repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000003884 213.0
HFD2_k127_4586484_0 NAD synthase K01916 - 6.3.1.5 6.227e-217 691.0
HFD2_k127_4586484_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 541.0
HFD2_k127_4586484_2 acr, cog1993 K09137 - - 0.000000000000000000000000000000000000000000000009144 173.0
HFD2_k127_4586484_3 Thioesterase superfamily - - - 0.00000000000000000000000000000000000002878 148.0
HFD2_k127_4586484_4 4Fe-4S single cluster domain K07001 - - 0.00000000000000000000000000000001078 139.0
HFD2_k127_4586484_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000008377 120.0
HFD2_k127_4586484_6 conserved protein (DUF2203) - - - 0.00000000000000000000000427 106.0
HFD2_k127_4586484_7 CBS domain - - - 0.00002373 52.0
HFD2_k127_4586484_8 SnoaL-like domain - - - 0.00007291 53.0
HFD2_k127_4592913_0 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 318.0
HFD2_k127_4592913_1 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003369 282.0
HFD2_k127_4592913_2 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000001615 129.0
HFD2_k127_4592913_3 (Barnase) inhibitor K03623 - - 0.0000000000000000000001528 99.0
HFD2_k127_4592913_4 DNA polymerase beta domain protein region K07075 - - 0.0000000000001196 72.0
HFD2_k127_4592913_5 Bacteriophage replication gene A protein (GPA) - - - 0.00000000001896 66.0
HFD2_k127_4592913_6 response to nickel cation - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0040008,GO:0045926,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0065007,GO:0097159,GO:1901363 - 0.00000001996 57.0
HFD2_k127_4592913_7 PFAM ABC transporter K09817 - - 0.00000002613 56.0
HFD2_k127_4592913_8 Transcriptional regulator - - - 0.000003644 54.0
HFD2_k127_4592913_9 FR47-like protein - - - 0.00005155 48.0
HFD2_k127_46132_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1017.0
HFD2_k127_46132_1 Carbamoyltransferase C-terminus K00612 - - 3.034e-316 1003.0
HFD2_k127_46132_10 Major facilitator Superfamily K00943,K08217,K18833 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 440.0
HFD2_k127_46132_11 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 414.0
HFD2_k127_46132_12 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 414.0
HFD2_k127_46132_13 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 406.0
HFD2_k127_46132_14 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 395.0
HFD2_k127_46132_15 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 382.0
HFD2_k127_46132_16 SMART von Willebrand factor, type A K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 317.0
HFD2_k127_46132_17 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003901 291.0
HFD2_k127_46132_18 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000345 275.0
HFD2_k127_46132_19 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007761 259.0
HFD2_k127_46132_2 Aldehyde dehydrogenase family K00138 - - 1.994e-277 859.0
HFD2_k127_46132_20 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000006849 241.0
HFD2_k127_46132_21 HAD-hyrolase-like K06019 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000005246 228.0
HFD2_k127_46132_22 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000001141 229.0
HFD2_k127_46132_23 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000002551 222.0
HFD2_k127_46132_24 Anion-transporting ATPase - - - 0.000000000000000000000000000000000000000000000000000000008137 216.0
HFD2_k127_46132_25 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000002849 202.0
HFD2_k127_46132_26 Protein of unknown function (DUF779) K09959 - - 0.000000000000000000000000000000000000000000000000000003063 193.0
HFD2_k127_46132_27 - - - - 0.000000000000000000000000000000000000000000000000000003421 203.0
HFD2_k127_46132_28 'Molybdopterin - - - 0.0000000000000000000000000000000000000000001431 174.0
HFD2_k127_46132_29 PFAM DSBA oxidoreductase - - - 0.000000000000000000000000000000000000000001109 179.0
HFD2_k127_46132_3 choline dehydrogenase activity K03333 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 4.83e-251 784.0
HFD2_k127_46132_30 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000001215 151.0
HFD2_k127_46132_31 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.00000000000000000000000000001502 127.0
HFD2_k127_46132_32 PHB/PHA accumulation regulator DNA-binding domain - - - 0.0000000000000000000000000000156 124.0
HFD2_k127_46132_33 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) - - - 0.00000000000000000000000000004587 127.0
HFD2_k127_46132_34 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000000003923 98.0
HFD2_k127_46132_35 lipolytic protein G-D-S-L family - - - 0.0000000000000000003842 100.0
HFD2_k127_46132_36 - - - - 0.0000000000001087 77.0
HFD2_k127_46132_37 lipolytic protein G-D-S-L family - - - 0.0000000000003438 81.0
HFD2_k127_46132_38 granule-associated protein - - - 0.000000000002827 75.0
HFD2_k127_46132_39 - - - - 0.0000000000842 72.0
HFD2_k127_46132_4 Malate synthase K01638 - 2.3.3.9 2.702e-222 700.0
HFD2_k127_46132_5 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 5.352e-210 665.0
HFD2_k127_46132_6 ABC1 family K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 510.0
HFD2_k127_46132_7 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 496.0
HFD2_k127_46132_8 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007818 464.0
HFD2_k127_46132_9 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 455.0
HFD2_k127_4687912_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01668 - 4.1.99.2 9.813e-265 822.0
HFD2_k127_4687912_1 Bacterial transcriptional activator domain K12132 - 2.7.11.1 2.297e-199 656.0
HFD2_k127_4687912_10 Single Cache domain 2 K07647 - 2.7.13.3 0.00000000000000000000000000000000000000000000004576 190.0
HFD2_k127_4687912_11 protein kinase activity - - - 0.0000000000000000000000000000000000000000000153 169.0
HFD2_k127_4687912_12 helix_turn_helix ASNC type - - - 0.000000000000000000000004718 112.0
HFD2_k127_4687912_13 protein kinase activity K12132 - 2.7.11.1 0.00000000000002071 83.0
HFD2_k127_4687912_14 YceI-like domain - - - 0.0000000000003113 79.0
HFD2_k127_4687912_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 469.0
HFD2_k127_4687912_3 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 415.0
HFD2_k127_4687912_4 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 322.0
HFD2_k127_4687912_5 protein possibly involved in utilization of glycolate and propanediol - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004096 252.0
HFD2_k127_4687912_6 PFAM Cache K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000003678 242.0
HFD2_k127_4687912_7 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000006108 240.0
HFD2_k127_4687912_8 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000002024 216.0
HFD2_k127_4687912_9 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000001914 201.0
HFD2_k127_4707307_0 - - - - 0.000000000000000005501 85.0
HFD2_k127_4707307_1 Domain of unknown function (DUF1772) - - - 0.000009705 49.0
HFD2_k127_4710766_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 2618.0
HFD2_k127_4710766_1 He_PIG associated, NEW1 domain of bacterial glycohydrolase - - - 1.294e-230 737.0
HFD2_k127_4710766_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007206 512.0
HFD2_k127_4710766_3 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 310.0
HFD2_k127_4710766_4 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 301.0
HFD2_k127_4710766_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002642 265.0
HFD2_k127_4710766_6 PFAM Cache K08738 - - 0.00000000000000000000000000000000000000000000000000000000000000003157 244.0
HFD2_k127_4710766_7 PFAM Cache type 2 domain protein - - - 0.0000000000000000000000000001505 132.0
HFD2_k127_4750749_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.000000000000000000000000000000000000000000000000000000004023 204.0
HFD2_k127_4750749_1 Belongs to the ompA family K03640 - - 0.00000000000000000001896 99.0
HFD2_k127_4776010_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 498.0
HFD2_k127_4781543_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 1.918e-267 833.0
HFD2_k127_4781543_1 Prolyl oligopeptidase family - - - 6.344e-259 818.0
HFD2_k127_4781543_10 type I secretion system ABC transporter, HlyB family K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 495.0
HFD2_k127_4781543_11 Tetratricopeptide repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 483.0
HFD2_k127_4781543_12 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 444.0
HFD2_k127_4781543_13 Aminotransferase class-III K03851,K15372 - 2.6.1.55,2.6.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 430.0
HFD2_k127_4781543_14 glycosyl transferase family 28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 378.0
HFD2_k127_4781543_15 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 372.0
HFD2_k127_4781543_16 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 379.0
HFD2_k127_4781543_17 PFAM Sodium sulfate symporter transmembrane region K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 365.0
HFD2_k127_4781543_18 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 338.0
HFD2_k127_4781543_19 Belongs to the bacterial solute-binding protein 9 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 330.0
HFD2_k127_4781543_2 amine dehydrogenase activity K17285 - - 8.448e-251 782.0
HFD2_k127_4781543_20 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 295.0
HFD2_k127_4781543_21 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 283.0
HFD2_k127_4781543_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004727 279.0
HFD2_k127_4781543_23 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005657 280.0
HFD2_k127_4781543_24 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007817 267.0
HFD2_k127_4781543_25 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006502 262.0
HFD2_k127_4781543_26 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002519 261.0
HFD2_k127_4781543_27 PFAM Cache K08738 - - 0.000000000000000000000000000000000000000000000000000000000000000001146 249.0
HFD2_k127_4781543_28 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000003226 235.0
HFD2_k127_4781543_29 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000006079 244.0
HFD2_k127_4781543_3 Peptidase U62 modulator of DNA gyrase K03568 - - 1.698e-246 773.0
HFD2_k127_4781543_30 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000001383 224.0
HFD2_k127_4781543_31 gluconolactonase activity K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000002171 226.0
HFD2_k127_4781543_32 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000008115 223.0
HFD2_k127_4781543_33 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity K16038 GO:0002682,GO:0002684,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 - 0.0000000000000000000000000000000000000000000000000000000000008949 223.0
HFD2_k127_4781543_34 - - - - 0.0000000000000000000000000000000000000000000000000000000001787 216.0
HFD2_k127_4781543_35 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000000001016 204.0
HFD2_k127_4781543_36 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000003535 188.0
HFD2_k127_4781543_37 - - - - 0.0000000000000000000000000000000000000000000002305 188.0
HFD2_k127_4781543_39 Single Cache domain 2 K07647 - 2.7.13.3 0.000000000000000000000000000000000000000000007061 183.0
HFD2_k127_4781543_4 Bacterial transcriptional activator domain K12132 - 2.7.11.1 1.395e-235 764.0
HFD2_k127_4781543_40 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000000000000000000008483 166.0
HFD2_k127_4781543_41 Acetyltransferase (GNAT) domain K03817 - - 0.00000000000000000000000000000000000000000002524 170.0
HFD2_k127_4781543_42 Belongs to the selenophosphate synthase 1 family. Class I subfamily K01008 - 2.7.9.3 0.00000000000000000000000000000000000000009131 172.0
HFD2_k127_4781543_43 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000003734 149.0
HFD2_k127_4781543_44 DinB family - - - 0.0000000000000000000000000000000000005557 152.0
HFD2_k127_4781543_46 Globin - - - 0.0000000000000000000000000000000005881 138.0
HFD2_k127_4781543_47 transglycosylase associated protein - - - 0.000000000000000000000000000006658 121.0
HFD2_k127_4781543_48 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000008787 126.0
HFD2_k127_4781543_49 Transcriptional - - - 0.00000000000000000000000004885 109.0
HFD2_k127_4781543_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 607.0
HFD2_k127_4781543_50 - - - - 0.0000000000000000000000002822 117.0
HFD2_k127_4781543_51 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000007794 108.0
HFD2_k127_4781543_52 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000246 101.0
HFD2_k127_4781543_53 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000001373 102.0
HFD2_k127_4781543_54 GAF domain K08968 - 1.8.4.14 0.0000000000000000005479 93.0
HFD2_k127_4781543_55 Cupin 2, conserved barrel domain protein - - - 0.000000000000000001041 96.0
HFD2_k127_4781543_56 Acetyltransferase (GNAT) domain K09994 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019634,GO:0019637,GO:0033051,GO:0044237,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - 0.000000000000000006067 91.0
HFD2_k127_4781543_57 Aerotolerance regulator N-terminal - - - 0.00000000000000008602 93.0
HFD2_k127_4781543_58 - - - - 0.0000000000000004028 84.0
HFD2_k127_4781543_59 - - - - 0.0000000000002188 81.0
HFD2_k127_4781543_6 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 562.0
HFD2_k127_4781543_60 Protein of unknown function (DUF4230) - - - 0.000000004827 65.0
HFD2_k127_4781543_61 Acetyltransferase (GNAT) family - - - 0.0000001851 64.0
HFD2_k127_4781543_62 Periplasmic component of the Tol biopolymer transport system K03641 - - 0.00013 51.0
HFD2_k127_4781543_63 Cupin domain - - - 0.0004987 51.0
HFD2_k127_4781543_7 COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 554.0
HFD2_k127_4781543_8 Rhodanese Homology Domain K01069,K03797 - 3.1.2.6,3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 540.0
HFD2_k127_4781543_9 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 542.0
HFD2_k127_4973256_0 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 585.0
HFD2_k127_4973256_1 dna ligase K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 518.0
HFD2_k127_4973256_10 HPP family K07168 - - 0.0000002249 59.0
HFD2_k127_4973256_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 312.0
HFD2_k127_4973256_3 ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002714 282.0
HFD2_k127_4973256_4 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003875 273.0
HFD2_k127_4973256_5 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000001217 254.0
HFD2_k127_4973256_6 PFAM Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000003512 243.0
HFD2_k127_4973256_7 ABC 3 transport family K09819,K11606,K11708,K11709 - - 0.00000000000000000000000000000000000000000000000000000000007873 213.0
HFD2_k127_4973256_8 transferase activity, transferring glycosyl groups K02844 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000000000354 152.0
HFD2_k127_4973256_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.000000000000005688 83.0
HFD2_k127_5097621_0 Involved in the tonB-independent uptake of proteins - - - 7.859e-280 899.0
HFD2_k127_5097621_1 HELICc2 K03722 - 3.6.4.12 1.611e-276 883.0
HFD2_k127_5097621_10 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 474.0
HFD2_k127_5097621_11 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 504.0
HFD2_k127_5097621_12 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 479.0
HFD2_k127_5097621_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 450.0
HFD2_k127_5097621_14 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 440.0
HFD2_k127_5097621_15 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008481 443.0
HFD2_k127_5097621_16 Protein of unknown function (DUF933) K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 440.0
HFD2_k127_5097621_17 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 410.0
HFD2_k127_5097621_18 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 402.0
HFD2_k127_5097621_19 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 396.0
HFD2_k127_5097621_2 Required for chromosome condensation and partitioning K03529 - - 2.722e-266 859.0
HFD2_k127_5097621_20 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 353.0
HFD2_k127_5097621_21 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 342.0
HFD2_k127_5097621_22 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 337.0
HFD2_k127_5097621_23 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 356.0
HFD2_k127_5097621_24 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009519 318.0
HFD2_k127_5097621_25 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 316.0
HFD2_k127_5097621_26 Dihydroxyacetone kinase family K07030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 318.0
HFD2_k127_5097621_27 Domain of unknown function (DUF4105) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 301.0
HFD2_k127_5097621_28 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 290.0
HFD2_k127_5097621_29 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009094 276.0
HFD2_k127_5097621_3 Aldehyde dehydrogenase family K22187 - - 7.965e-253 787.0
HFD2_k127_5097621_30 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002421 264.0
HFD2_k127_5097621_31 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000001399 259.0
HFD2_k127_5097621_32 Bacterial capsule synthesis protein PGA_cap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001358 251.0
HFD2_k127_5097621_33 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000003964 250.0
HFD2_k127_5097621_34 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000001781 237.0
HFD2_k127_5097621_35 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000001149 235.0
HFD2_k127_5097621_36 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.0000000000000000000000000000000000000000000000000000000000006356 223.0
HFD2_k127_5097621_37 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000003542 219.0
HFD2_k127_5097621_38 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000000000000000000000000000000000000000954 216.0
HFD2_k127_5097621_39 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000008259 218.0
HFD2_k127_5097621_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007605 598.0
HFD2_k127_5097621_40 Belongs to the BI1 family K06890,K19416 - - 0.000000000000000000000000000000000000000000000000000009966 206.0
HFD2_k127_5097621_41 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000000000000000000000004125 192.0
HFD2_k127_5097621_42 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000003183 198.0
HFD2_k127_5097621_43 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000005153 181.0
HFD2_k127_5097621_44 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000006524 175.0
HFD2_k127_5097621_45 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000008706 179.0
HFD2_k127_5097621_46 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000009978 169.0
HFD2_k127_5097621_47 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000008043 160.0
HFD2_k127_5097621_48 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.000000000000000000000000000000000000000006485 159.0
HFD2_k127_5097621_49 Belongs to the 5'-nucleotidase family - - - 0.00000000000000000000000000000000000000009322 173.0
HFD2_k127_5097621_5 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000791 588.0
HFD2_k127_5097621_50 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000001385 171.0
HFD2_k127_5097621_51 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000001412 162.0
HFD2_k127_5097621_52 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000000000000001656 153.0
HFD2_k127_5097621_53 Domain of unknown function (DUF2520) - - - 0.00000000000000000000000000000000000001941 165.0
HFD2_k127_5097621_54 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000006256 147.0
HFD2_k127_5097621_55 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000007867 139.0
HFD2_k127_5097621_56 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division K20543 - - 0.000000000000000000000000000000009668 146.0
HFD2_k127_5097621_57 Permease MlaE K02066 - - 0.00000000000000000000000000000001697 136.0
HFD2_k127_5097621_58 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000001229 129.0
HFD2_k127_5097621_59 chain release factor K15034 - - 0.00000000000000000000000000000573 124.0
HFD2_k127_5097621_6 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 576.0
HFD2_k127_5097621_60 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000000001521 126.0
HFD2_k127_5097621_61 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000001049 118.0
HFD2_k127_5097621_62 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000004866 125.0
HFD2_k127_5097621_63 Sporulation related domain - - - 0.000000000000000000000000006124 125.0
HFD2_k127_5097621_64 - - - - 0.0000000000000000000000001071 114.0
HFD2_k127_5097621_65 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000001142 104.0
HFD2_k127_5097621_66 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000008675 117.0
HFD2_k127_5097621_67 Binds the 23S rRNA K02909 - - 0.00000000000000000000001098 105.0
HFD2_k127_5097621_68 - - - - 0.00000000000000002754 96.0
HFD2_k127_5097621_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 516.0
HFD2_k127_5097621_70 Control of competence regulator ComK, YlbF/YmcA - - - 0.0000000000000001148 83.0
HFD2_k127_5097621_71 - - - - 0.0000000000001372 82.0
HFD2_k127_5097621_72 membrane transporter protein K07090 - - 0.000000000001253 78.0
HFD2_k127_5097621_73 ABC transporter K02065 - - 0.000000000004613 78.0
HFD2_k127_5097621_74 Psort location CytoplasmicMembrane, score - - - 0.000002344 59.0
HFD2_k127_5097621_75 - - - - 0.00006739 53.0
HFD2_k127_5097621_76 Peptidase s1 and s6 chymotrypsin hap K08372 - - 0.0001648 53.0
HFD2_k127_5097621_77 MlaD protein K06192 - - 0.0008797 51.0
HFD2_k127_5097621_8 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 548.0
HFD2_k127_5097621_9 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003247 482.0
HFD2_k127_5105254_0 Protein kinase domain K12132 - 2.7.11.1 5.714e-280 896.0
HFD2_k127_5105254_1 2-Nitropropane dioxygenase K00459 - 1.13.12.16 2.116e-200 638.0
HFD2_k127_5105254_10 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000001693 182.0
HFD2_k127_5105254_11 transcriptional regulator, ArsR family - - - 0.00000000000000000000000000000000000000000000001804 175.0
HFD2_k127_5105254_12 - - - - 0.00000000000000000000000000000000000001649 151.0
HFD2_k127_5105254_13 acetyltransferase K19113 - - 0.0000000000000000000000000000000007212 147.0
HFD2_k127_5105254_14 Amidohydrolase - - - 0.00000000000000000009068 102.0
HFD2_k127_5105254_2 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 607.0
HFD2_k127_5105254_3 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 548.0
HFD2_k127_5105254_4 Sodium:dicarboxylate symporter family K11102 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005692 499.0
HFD2_k127_5105254_5 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 513.0
HFD2_k127_5105254_6 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 415.0
HFD2_k127_5105254_8 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 289.0
HFD2_k127_5105254_9 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001387 259.0
HFD2_k127_5116006_0 Ftsk_gamma K03466 - - 3.928e-210 679.0
HFD2_k127_5116006_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 585.0
HFD2_k127_5116006_10 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004164 265.0
HFD2_k127_5116006_11 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000004046 251.0
HFD2_k127_5116006_12 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000000258 213.0
HFD2_k127_5116006_13 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000001495 201.0
HFD2_k127_5116006_14 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000000000335 180.0
HFD2_k127_5116006_15 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000001292 170.0
HFD2_k127_5116006_16 OmpA family K03640 - - 0.0000000000000000000000000000000000003812 147.0
HFD2_k127_5116006_17 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000000000000000000004313 143.0
HFD2_k127_5116006_18 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000001178 128.0
HFD2_k127_5116006_19 TonB C terminal K03832 - - 0.00000000000000000000000000009498 126.0
HFD2_k127_5116006_2 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 594.0
HFD2_k127_5116006_20 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000262 78.0
HFD2_k127_5116006_21 Domain of unknown function (DUF4321) - - - 0.000000000000006385 81.0
HFD2_k127_5116006_22 cellulase activity K06882 - - 0.00000000000003888 84.0
HFD2_k127_5116006_23 peptidyl-tyrosine sulfation - - - 0.000000003487 70.0
HFD2_k127_5116006_24 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000001457 65.0
HFD2_k127_5116006_3 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 517.0
HFD2_k127_5116006_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 507.0
HFD2_k127_5116006_5 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 476.0
HFD2_k127_5116006_6 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 381.0
HFD2_k127_5116006_7 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006391 358.0
HFD2_k127_5116006_8 SurA N-terminal domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 325.0
HFD2_k127_5116006_9 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 310.0
HFD2_k127_5175637_0 LVIVD repeat - - - 8.453e-254 819.0
HFD2_k127_5175637_1 alpha-glucan phosphorylase K00688 - 2.4.1.1 1.218e-234 749.0
HFD2_k127_5175637_10 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 310.0
HFD2_k127_5175637_11 cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004974 292.0
HFD2_k127_5175637_12 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001148 280.0
HFD2_k127_5175637_13 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000001663 211.0
HFD2_k127_5175637_14 Domain of unknown function (DUF305) - - - 0.000000000000000000000000000000000000000000000000000000003759 213.0
HFD2_k127_5175637_15 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.00000000000000000000000000000000000000000000000000007947 190.0
HFD2_k127_5175637_16 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000902 174.0
HFD2_k127_5175637_17 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000008621 136.0
HFD2_k127_5175637_18 HAF family - - - 0.000000000000000000000000001263 127.0
HFD2_k127_5175637_19 PFAM Iron-binding zinc finger CDGSH type K22405 - 1.6.3.4 0.00000000000000000000000001552 114.0
HFD2_k127_5175637_2 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 607.0
HFD2_k127_5175637_21 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000009685 50.0
HFD2_k127_5175637_3 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004764 616.0
HFD2_k127_5175637_4 COG0076 Glutamate decarboxylase and related PLP-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 479.0
HFD2_k127_5175637_5 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 477.0
HFD2_k127_5175637_6 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 451.0
HFD2_k127_5175637_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 429.0
HFD2_k127_5175637_8 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 333.0
HFD2_k127_5175637_9 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 323.0
HFD2_k127_5189267_0 COG1020 Non-ribosomal peptide synthetase modules and related proteins K02364 - 6.3.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 564.0
HFD2_k127_5189267_1 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 374.0
HFD2_k127_5189267_2 - - - - 0.0000000000000000000000000000005543 136.0
HFD2_k127_5189267_3 Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall K14188 - 6.1.1.13 0.00000001106 59.0
HFD2_k127_5216755_0 Domain of unknown function (DUF3473) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 612.0
HFD2_k127_5216755_1 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008798 611.0
HFD2_k127_5216755_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 506.0
HFD2_k127_5216755_3 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 377.0
HFD2_k127_5216755_4 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000003813 256.0
HFD2_k127_5216755_5 PFAM Acyltransferase - - - 0.0000000000000000000000003651 117.0
HFD2_k127_5216755_6 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0001155 49.0
HFD2_k127_5224580_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 292.0
HFD2_k127_5224580_1 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002749 271.0
HFD2_k127_5224580_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000002181 183.0
HFD2_k127_5224580_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000001634 126.0
HFD2_k127_5224580_4 metallopeptidase activity K01179 - 3.2.1.4 0.0000000000003118 78.0
HFD2_k127_5224584_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 1.372e-284 897.0
HFD2_k127_5224584_1 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 510.0
HFD2_k127_5224584_10 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000001365 165.0
HFD2_k127_5224584_11 NapC/NirT cytochrome c family, N-terminal region - - - 0.0000000000000000000000000000000009091 150.0
HFD2_k127_5224584_12 ferredoxin-NADP+ reductase activity - - - 0.0000000000000000000000000000001249 137.0
HFD2_k127_5224584_13 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000002979 136.0
HFD2_k127_5224584_14 anaerobic respiration K02568 - - 0.000000000000000000000000000003129 132.0
HFD2_k127_5224584_15 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000003143 115.0
HFD2_k127_5224584_16 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000001003 81.0
HFD2_k127_5224584_18 ATPase activity, coupled to transmembrane movement of substances K02120 - - 0.0004005 46.0
HFD2_k127_5224584_2 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 488.0
HFD2_k127_5224584_3 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 472.0
HFD2_k127_5224584_4 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 417.0
HFD2_k127_5224584_5 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 432.0
HFD2_k127_5224584_6 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 398.0
HFD2_k127_5224584_7 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 401.0
HFD2_k127_5224584_8 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 289.0
HFD2_k127_5224584_9 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002076 279.0
HFD2_k127_523113_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009073 529.0
HFD2_k127_523113_1 PFAM aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 462.0
HFD2_k127_523113_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000003466 122.0
HFD2_k127_523113_11 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000003342 88.0
HFD2_k127_523113_12 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor - - - 0.00000196 59.0
HFD2_k127_523113_13 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000004933 49.0
HFD2_k127_523113_2 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 427.0
HFD2_k127_523113_3 ornithine cyclodeaminase activity K01750,K18258,K19244 - 1.4.1.1,1.5.1.25,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 299.0
HFD2_k127_523113_4 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001673 267.0
HFD2_k127_523113_5 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006675 254.0
HFD2_k127_523113_6 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000002381 225.0
HFD2_k127_523113_7 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000001024 168.0
HFD2_k127_523113_8 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000001393 169.0
HFD2_k127_523113_9 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000001197 144.0
HFD2_k127_5286702_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 2.746e-252 791.0
HFD2_k127_5286702_1 Flavin containing amine oxidoreductase - - - 1.141e-195 622.0
HFD2_k127_5286702_10 arylsulfatase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004581 265.0
HFD2_k127_5286702_11 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000001382 241.0
HFD2_k127_5286702_12 PFAM UbiA prenyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000007978 233.0
HFD2_k127_5286702_13 adenylylsulfate kinase activity K00860,K00955 GO:0003674,GO:0003824,GO:0004020,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000006182 233.0
HFD2_k127_5286702_14 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000641 219.0
HFD2_k127_5286702_15 alpha-L-arabinofuranosidase - - - 0.0000000000000000000000000000000000000000000000002345 188.0
HFD2_k127_5286702_16 Domain of unknown function (DUF4956) - - - 0.00000000000000000000000000000000000000000000004668 178.0
HFD2_k127_5286702_17 COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation - - - 0.000000000000000000000000000000000000000007833 164.0
HFD2_k127_5286702_18 CotH kinase protein - - - 0.0000000000000000000000000000000000001393 164.0
HFD2_k127_5286702_19 Polysaccharide deacetylase - - - 0.000000000000000000000000000000003676 138.0
HFD2_k127_5286702_2 Phosphoadenosine phosphosulfate reductase family K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 512.0
HFD2_k127_5286702_20 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.00000000000000000001449 102.0
HFD2_k127_5286702_21 Polysaccharide biosynthesis protein - - - 0.00000000000000001499 97.0
HFD2_k127_5286702_22 - - - - 0.0000001091 64.0
HFD2_k127_5286702_23 Flavin containing amine oxidoreductase - - - 0.000000114 60.0
HFD2_k127_5286702_3 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 447.0
HFD2_k127_5286702_4 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 400.0
HFD2_k127_5286702_5 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 331.0
HFD2_k127_5286702_6 Inositol monophosphatase family K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008203 315.0
HFD2_k127_5286702_7 adenylylsulfate kinase activity K00860,K00955 GO:0003674,GO:0003824,GO:0004020,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 296.0
HFD2_k127_5286702_8 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 298.0
HFD2_k127_5286702_9 arylsulfatase A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009872 284.0
HFD2_k127_5354291_0 DEAD DEAH box helicase K03724 - - 0.0 1603.0
HFD2_k127_5354291_1 DNA ligase (ATP) activity K01971 - 6.5.1.1 0.0 1112.0
HFD2_k127_5354291_10 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 511.0
HFD2_k127_5354291_11 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 486.0
HFD2_k127_5354291_12 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 498.0
HFD2_k127_5354291_13 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 439.0
HFD2_k127_5354291_14 Nitronate monooxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 430.0
HFD2_k127_5354291_15 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004938 403.0
HFD2_k127_5354291_16 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005466 385.0
HFD2_k127_5354291_17 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008694 392.0
HFD2_k127_5354291_18 Nucleoside recognition K06373 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 368.0
HFD2_k127_5354291_19 3' exoribonuclease, RNase T-like K03656,K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 391.0
HFD2_k127_5354291_2 ATP-dependent helicase K03579 - 3.6.4.13 1.435e-294 948.0
HFD2_k127_5354291_20 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 376.0
HFD2_k127_5354291_21 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 360.0
HFD2_k127_5354291_22 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 355.0
HFD2_k127_5354291_23 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 349.0
HFD2_k127_5354291_24 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 369.0
HFD2_k127_5354291_25 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008637 352.0
HFD2_k127_5354291_26 ABC-type multidrug transport system ATPase and permease K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 341.0
HFD2_k127_5354291_27 High-affinity nickel-transport protein K07241 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 294.0
HFD2_k127_5354291_28 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 304.0
HFD2_k127_5354291_29 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 287.0
HFD2_k127_5354291_3 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 8.89e-287 913.0
HFD2_k127_5354291_30 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001036 269.0
HFD2_k127_5354291_31 Nucleoside recognition K06374 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001204 274.0
HFD2_k127_5354291_32 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008061 267.0
HFD2_k127_5354291_33 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008916 276.0
HFD2_k127_5354291_34 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000017 254.0
HFD2_k127_5354291_35 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004039 250.0
HFD2_k127_5354291_37 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000000001321 235.0
HFD2_k127_5354291_38 Armadillo/beta-catenin-like repeats - - - 0.00000000000000000000000000000000000000000000000000000000000001359 235.0
HFD2_k127_5354291_39 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000005824 220.0
HFD2_k127_5354291_4 Protein kinase domain K12132 - 2.7.11.1 4.807e-269 853.0
HFD2_k127_5354291_40 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000006406 227.0
HFD2_k127_5354291_41 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000005308 218.0
HFD2_k127_5354291_42 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000001147 217.0
HFD2_k127_5354291_43 COG4257 Streptogramin lyase - - - 0.0000000000000000000000000000000000000000000000000000007354 211.0
HFD2_k127_5354291_44 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000006577 207.0
HFD2_k127_5354291_45 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000001009 201.0
HFD2_k127_5354291_46 iron-regulated membrane protein K03863 - - 0.00000000000000000000000000000000000000000000000005162 193.0
HFD2_k127_5354291_47 Kelch-like protein 17 K10454 GO:0000151,GO:0003674,GO:0003779,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006996,GO:0007010,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008092,GO:0008150,GO:0009987,GO:0014069,GO:0015629,GO:0016043,GO:0019904,GO:0030029,GO:0030036,GO:0030425,GO:0031208,GO:0031461,GO:0031463,GO:0032279,GO:0032501,GO:0032502,GO:0032838,GO:0032839,GO:0032947,GO:0032991,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044297,GO:0044424,GO:0044444,GO:0044456,GO:0044463,GO:0044464,GO:0044877,GO:0045202,GO:0048513,GO:0048731,GO:0048856,GO:0051015,GO:0060322,GO:0071840,GO:0097447,GO:0097458,GO:0098794,GO:0098984,GO:0099568,GO:0099572,GO:0120025,GO:0120038,GO:0120111,GO:1902494,GO:1990234 - 0.0000000000000000000000000000000000000000002844 175.0
HFD2_k127_5354291_48 regulation of single-species biofilm formation K13572,K13573 - - 0.000000000000000000000000000000000000000001003 171.0
HFD2_k127_5354291_49 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000002264 159.0
HFD2_k127_5354291_5 Peptidase family M1 domain - - - 1.756e-237 745.0
HFD2_k127_5354291_50 LemA family K03744 - - 0.000000000000000000000000000000000000000003184 165.0
HFD2_k127_5354291_51 Probable zinc-ribbon domain - - - 0.00000000000000000000000000000000000000001775 160.0
HFD2_k127_5354291_52 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000000005638 157.0
HFD2_k127_5354291_53 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000002571 142.0
HFD2_k127_5354291_54 Cold shock K03704 - - 0.00000000000000000000000000000000004451 134.0
HFD2_k127_5354291_56 - - - - 0.00000000000000000000000000000006727 142.0
HFD2_k127_5354291_57 domain protein K13735 - - 0.000000000000000000000000003091 129.0
HFD2_k127_5354291_58 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000002039 119.0
HFD2_k127_5354291_59 Proteasome accessory factor C K13573 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000005054 119.0
HFD2_k127_5354291_6 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.537e-235 739.0
HFD2_k127_5354291_60 PDZ domain - - - 0.000000000000000000000006808 114.0
HFD2_k127_5354291_61 nuclear chromosome segregation - - - 0.00000000000000000000002453 110.0
HFD2_k127_5354291_62 DNA-templated transcription, initiation - - - 0.00000000000000000001623 99.0
HFD2_k127_5354291_63 domain protein K13735 - - 0.000000000000000001035 102.0
HFD2_k127_5354291_64 Divergent 4Fe-4S mono-cluster - - - 0.000000000000000026 86.0
HFD2_k127_5354291_65 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000004211 84.0
HFD2_k127_5354291_66 - - - - 0.000000000003674 70.0
HFD2_k127_5354291_67 Ribosomal protein S21 K02970 - - 0.00000000001187 66.0
HFD2_k127_5354291_68 Histidine kinase - - - 0.000000003467 63.0
HFD2_k127_5354291_69 - - - - 0.00000003949 64.0
HFD2_k127_5354291_7 Peptidase family M28 - - - 3.513e-232 732.0
HFD2_k127_5354291_70 BON domain - - - 0.000008681 56.0
HFD2_k127_5354291_71 - - - - 0.0005 48.0
HFD2_k127_5354291_8 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 585.0
HFD2_k127_5354291_9 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 505.0
HFD2_k127_5454199_0 Alpha amylase, catalytic domain - - - 2.409e-202 648.0
HFD2_k127_5454199_1 major facilitator K16211 - - 2.583e-201 639.0
HFD2_k127_5454199_2 Alpha amylase, catalytic domain K01176 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 617.0
HFD2_k127_5454199_3 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 379.0
HFD2_k127_5454199_4 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000002293 201.0
HFD2_k127_5454199_5 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000002347 169.0
HFD2_k127_5454199_6 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000001031 91.0
HFD2_k127_5454199_7 abc-type fe3 -hydroxamate transport system, periplasmic component - - - 0.00000000001106 66.0
HFD2_k127_5467446_0 DNA restriction-modification system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 460.0
HFD2_k127_5467446_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 350.0
HFD2_k127_5467446_2 SNF2 family N-terminal domain - - - 0.00000000000000000000000000000000001154 157.0
HFD2_k127_5515216_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 6.744e-313 973.0
HFD2_k127_5515216_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.05e-295 921.0
HFD2_k127_5515216_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000003068 260.0
HFD2_k127_5515216_3 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000328 206.0
HFD2_k127_5515216_4 EVE domain - - - 0.000000000000000000000000000000000000001966 163.0
HFD2_k127_5515216_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.0000000000000000000000000000009261 129.0
HFD2_k127_5515216_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.00000000000000000000000007061 115.0
HFD2_k127_5515216_7 peptidoglycan-binding protein, lysm - - - 0.0000000000000001377 92.0
HFD2_k127_5515216_8 Glycoprotease family K14742 - - 0.000000000000000912 89.0
HFD2_k127_5588313_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007095 509.0
HFD2_k127_5588313_1 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000145 117.0
HFD2_k127_5588313_2 Peptidase family M28 - - - 0.0000000000000000001686 93.0
HFD2_k127_5627274_0 FAD dependent oxidoreductase - - - 2.513e-230 724.0
HFD2_k127_5627274_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 332.0
HFD2_k127_5627274_2 - - - - 0.00004094 54.0
HFD2_k127_5642380_0 Di-haem cytochrome c peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 601.0
HFD2_k127_5655001_0 Polysaccharide biosynthesis/export protein - - - 8.907e-275 872.0
HFD2_k127_5655001_1 CoA-binding domain - - - 5.252e-205 655.0
HFD2_k127_5655001_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006156 280.0
HFD2_k127_5655001_3 glycosyl transferase group 1 K08256,K12995 - 2.4.1.345,2.4.1.348 0.00000000000000000000000000000000000000000000000000003109 201.0
HFD2_k127_5655001_4 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000001896 195.0
HFD2_k127_5655001_5 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000001571 165.0
HFD2_k127_5854078_0 Amidohydrolase family K06015 - 3.5.1.81 5.284e-220 694.0
HFD2_k127_5854078_1 Sodium/hydrogen exchanger family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 606.0
HFD2_k127_5854078_2 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 334.0
HFD2_k127_5854078_3 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 306.0
HFD2_k127_5854078_4 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001875 301.0
HFD2_k127_5854078_5 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000006367 253.0
HFD2_k127_5854078_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000001214 244.0
HFD2_k127_5854078_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145,K05829 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000007313 229.0
HFD2_k127_5854078_8 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000000000000002263 112.0
HFD2_k127_5854078_9 Mo-molybdopterin cofactor biosynthetic process - - - 0.0000001694 56.0
HFD2_k127_5890476_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 606.0
HFD2_k127_5890476_1 RDD family K06384 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 344.0
HFD2_k127_5890476_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001259 284.0
HFD2_k127_5890476_3 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000008786 198.0
HFD2_k127_5890476_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000007045 135.0
HFD2_k127_5890476_6 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000002323 71.0
HFD2_k127_5890476_7 Domain of unknown function (DUF4129) - - - 0.000001484 61.0
HFD2_k127_6102261_0 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 457.0
HFD2_k127_6102261_1 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009345 394.0
HFD2_k127_6102261_2 domain protein K13735 - - 0.0004578 51.0
HFD2_k127_6148573_0 beta-galactosidase activity K01190 - 3.2.1.23 2.906e-296 927.0
HFD2_k127_6148573_1 Glycogen debranching enzyme, glucanotransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 392.0
HFD2_k127_6148573_2 hydrolase activity, hydrolyzing O-glycosyl compounds K01176,K01200 - 3.2.1.1,3.2.1.41 0.00000001019 57.0
HFD2_k127_6168099_0 Esterase PHB depolymerase K03932 - - 0.0000000000000000000000000000000000000000002397 170.0
HFD2_k127_6171633_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008935 582.0
HFD2_k127_6171633_1 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 542.0
HFD2_k127_6171633_2 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 398.0
HFD2_k127_6171633_3 domain protein K13735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004152 291.0
HFD2_k127_6171633_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000001263 208.0
HFD2_k127_6171633_5 Bacterial Ig-like domain - - - 0.000000000000000000000000000000000000000000000000734 192.0
HFD2_k127_6171633_6 Protein conserved in bacteria - - - 0.00000000000000000000000000000000001012 148.0
HFD2_k127_6204613_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.361e-296 927.0
HFD2_k127_6204613_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.168e-282 880.0
HFD2_k127_6204613_10 B3/4 domain K01890 - 6.1.1.20 5.745e-195 636.0
HFD2_k127_6204613_100 - - - - 0.0000000000000000000000000000000000000000000001007 176.0
HFD2_k127_6204613_101 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000000000006464 173.0
HFD2_k127_6204613_102 acetyltransferase K22441 - 2.3.1.57 0.00000000000000000000000000000000000000000001936 169.0
HFD2_k127_6204613_103 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000005188 165.0
HFD2_k127_6204613_105 DinB family - - - 0.00000000000000000000000000000000000000002259 160.0
HFD2_k127_6204613_106 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000000000002856 159.0
HFD2_k127_6204613_107 Acyl-ACP thioesterase - - - 0.00000000000000000000000000000000000000008238 165.0
HFD2_k127_6204613_108 Biotin-requiring enzyme - - - 0.0000000000000000000000000000000000000005772 154.0
HFD2_k127_6204613_109 YCII-related domain - - - 0.00000000000000000000000000000000000000227 154.0
HFD2_k127_6204613_11 Hsp70 protein K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 592.0
HFD2_k127_6204613_110 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000002682 155.0
HFD2_k127_6204613_111 STAS domain K04749 - - 0.000000000000000000000000000000000000008392 148.0
HFD2_k127_6204613_112 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000009489 150.0
HFD2_k127_6204613_113 Domain of unknown function (DUF3597) - - - 0.00000000000000000000000000000000000001883 147.0
HFD2_k127_6204613_114 YCII-related domain K09780 - - 0.00000000000000000000000000000000000001967 153.0
HFD2_k127_6204613_115 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000006974 145.0
HFD2_k127_6204613_116 Cupin domain - - - 0.0000000000000000000000000000000000001641 145.0
HFD2_k127_6204613_117 Thioesterase superfamily - - - 0.0000000000000000000000000000000000002571 147.0
HFD2_k127_6204613_118 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000029 149.0
HFD2_k127_6204613_119 Transcription factor zinc-finger - - - 0.000000000000000000000000000000000006939 141.0
HFD2_k127_6204613_12 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 572.0
HFD2_k127_6204613_120 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000005069 141.0
HFD2_k127_6204613_121 pathogenesis K07507 - - 0.0000000000000000000000000000000000543 146.0
HFD2_k127_6204613_123 - - - - 0.0000000000000000000000000000000002989 141.0
HFD2_k127_6204613_124 - - - - 0.000000000000000000000000000000005294 139.0
HFD2_k127_6204613_125 Tellurite resistance protein TerB - - - 0.000000000000000000000000000000008802 133.0
HFD2_k127_6204613_126 Protein of unknown function (DUF3175) - - - 0.00000000000000000000000000000002014 132.0
HFD2_k127_6204613_127 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000003788 142.0
HFD2_k127_6204613_128 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000006068 129.0
HFD2_k127_6204613_129 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000001376 136.0
HFD2_k127_6204613_13 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 550.0
HFD2_k127_6204613_130 Protein of unknown function (DUF3303) - - - 0.0000000000000000000000000000006155 123.0
HFD2_k127_6204613_131 - - - - 0.00000000000000000000000000000174 127.0
HFD2_k127_6204613_132 PFAM Acetyltransferase (GNAT) family K03790 - 2.3.1.128 0.000000000000000000000000000008367 119.0
HFD2_k127_6204613_133 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000007263 135.0
HFD2_k127_6204613_134 - - - - 0.0000000000000000000000000003547 120.0
HFD2_k127_6204613_135 ACT domain K09964 - - 0.0000000000000000000000000004311 121.0
HFD2_k127_6204613_136 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000005717 119.0
HFD2_k127_6204613_137 DinB superfamily - - - 0.000000000000000000000000002029 120.0
HFD2_k127_6204613_138 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000008666 116.0
HFD2_k127_6204613_139 Psort location Cytoplasmic, score 8.87 - - - 0.00000000000000000000000001413 113.0
HFD2_k127_6204613_14 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 533.0
HFD2_k127_6204613_140 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000001536 116.0
HFD2_k127_6204613_141 rod shape-determining protein MreD K03571 - - 0.00000000000000000000000009086 115.0
HFD2_k127_6204613_142 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K07443 - - 0.000000000000000000000000162 112.0
HFD2_k127_6204613_143 HD domain - - - 0.0000000000000000000000001944 121.0
HFD2_k127_6204613_144 methylamine metabolic process K15977 - - 0.0000000000000000000000002057 112.0
HFD2_k127_6204613_145 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000005723 119.0
HFD2_k127_6204613_146 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000006605 113.0
HFD2_k127_6204613_147 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.00000000000000000000002171 109.0
HFD2_k127_6204613_148 Ribosomal protein S21 K02970 - - 0.0000000000000000000002 100.0
HFD2_k127_6204613_149 - - - - 0.0000000000000000000003099 102.0
HFD2_k127_6204613_15 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007256 532.0
HFD2_k127_6204613_151 Regulator of ribonuclease activity B - - - 0.000000000000000000035 95.0
HFD2_k127_6204613_152 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000003542 91.0
HFD2_k127_6204613_154 - - - - 0.000000000000000004277 95.0
HFD2_k127_6204613_155 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.000000000000000004454 94.0
HFD2_k127_6204613_156 - - - - 0.000000000000000007112 94.0
HFD2_k127_6204613_157 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000004032 89.0
HFD2_k127_6204613_158 Domain of unknown function (DUF4286) - - - 0.00000000000000009618 87.0
HFD2_k127_6204613_159 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000001044 83.0
HFD2_k127_6204613_16 DHH family K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 505.0
HFD2_k127_6204613_160 glucose sorbosone - - - 0.0000000000008086 75.0
HFD2_k127_6204613_161 Type II secretion system (T2SS), protein G - - - 0.00000000002441 73.0
HFD2_k127_6204613_162 - - - - 0.00000000002764 78.0
HFD2_k127_6204613_163 Transcriptional regulatory protein, C terminal - - - 0.00000000003097 67.0
HFD2_k127_6204613_164 Domain of unknown function (DUF4375) - - - 0.0000000003376 68.0
HFD2_k127_6204613_165 - - - - 0.000000001609 66.0
HFD2_k127_6204613_166 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000004435 63.0
HFD2_k127_6204613_169 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000002824 62.0
HFD2_k127_6204613_17 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 503.0
HFD2_k127_6204613_171 - - - - 0.0000002607 63.0
HFD2_k127_6204613_173 Prepilin-type N-terminal cleavage methylation domain K02456,K02650 - - 0.000001113 60.0
HFD2_k127_6204613_174 - - - - 0.000004171 59.0
HFD2_k127_6204613_175 - - - - 0.000006201 51.0
HFD2_k127_6204613_176 Domain of unknown function (DUF4340) - - - 0.000018 57.0
HFD2_k127_6204613_178 Histidine kinase - - - 0.0008566 51.0
HFD2_k127_6204613_18 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005884 507.0
HFD2_k127_6204613_19 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 460.0
HFD2_k127_6204613_2 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 4.309e-259 805.0
HFD2_k127_6204613_20 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 450.0
HFD2_k127_6204613_21 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 431.0
HFD2_k127_6204613_22 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 428.0
HFD2_k127_6204613_23 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 424.0
HFD2_k127_6204613_24 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 413.0
HFD2_k127_6204613_25 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 410.0
HFD2_k127_6204613_26 Cell cycle protein K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 410.0
HFD2_k127_6204613_27 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 426.0
HFD2_k127_6204613_28 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 384.0
HFD2_k127_6204613_29 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 385.0
HFD2_k127_6204613_3 Carbamoyltransferase C-terminus K00612 - - 9.038e-251 790.0
HFD2_k127_6204613_30 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 380.0
HFD2_k127_6204613_31 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 404.0
HFD2_k127_6204613_32 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 381.0
HFD2_k127_6204613_33 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800,K00945 - 2.5.1.19,2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 368.0
HFD2_k127_6204613_34 beta-lactamase K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 359.0
HFD2_k127_6204613_35 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 365.0
HFD2_k127_6204613_36 Ribosomal protein S2 K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009342 347.0
HFD2_k127_6204613_37 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 365.0
HFD2_k127_6204613_38 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 331.0
HFD2_k127_6204613_39 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 333.0
HFD2_k127_6204613_4 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.28e-248 781.0
HFD2_k127_6204613_40 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 326.0
HFD2_k127_6204613_41 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 328.0
HFD2_k127_6204613_42 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 310.0
HFD2_k127_6204613_43 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 314.0
HFD2_k127_6204613_44 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 318.0
HFD2_k127_6204613_45 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 311.0
HFD2_k127_6204613_46 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 319.0
HFD2_k127_6204613_47 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 307.0
HFD2_k127_6204613_48 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 301.0
HFD2_k127_6204613_49 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 317.0
HFD2_k127_6204613_5 Amino acid permease - - - 7.212e-218 696.0
HFD2_k127_6204613_50 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 309.0
HFD2_k127_6204613_51 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 297.0
HFD2_k127_6204613_52 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 295.0
HFD2_k127_6204613_53 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 292.0
HFD2_k127_6204613_54 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003778 275.0
HFD2_k127_6204613_55 (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003631 275.0
HFD2_k127_6204613_56 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001507 279.0
HFD2_k127_6204613_57 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001719 268.0
HFD2_k127_6204613_58 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000007068 272.0
HFD2_k127_6204613_59 Haemolysin-III related K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003154 262.0
HFD2_k127_6204613_6 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.43e-208 661.0
HFD2_k127_6204613_60 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000425 258.0
HFD2_k127_6204613_61 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002194 248.0
HFD2_k127_6204613_62 Glutamine amidotransferase class-I K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000224 249.0
HFD2_k127_6204613_63 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003604 246.0
HFD2_k127_6204613_64 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000007523 243.0
HFD2_k127_6204613_65 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000001745 247.0
HFD2_k127_6204613_66 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000021 236.0
HFD2_k127_6204613_67 PFAM PEBP family protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000009709 246.0
HFD2_k127_6204613_68 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000001607 256.0
HFD2_k127_6204613_69 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000001935 246.0
HFD2_k127_6204613_7 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 9.486e-202 641.0
HFD2_k127_6204613_70 Protein of unknown function DUF99 K09120 - - 0.000000000000000000000000000000000000000000000000000000000000000008353 229.0
HFD2_k127_6204613_71 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000001078 241.0
HFD2_k127_6204613_72 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000001049 230.0
HFD2_k127_6204613_73 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000001409 232.0
HFD2_k127_6204613_74 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000006614 238.0
HFD2_k127_6204613_75 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000139 240.0
HFD2_k127_6204613_76 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000002336 230.0
HFD2_k127_6204613_77 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000082 220.0
HFD2_k127_6204613_78 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000794 218.0
HFD2_k127_6204613_79 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000001163 217.0
HFD2_k127_6204613_8 Endoribonuclease that initiates mRNA decay K18682 - - 1.679e-195 629.0
HFD2_k127_6204613_80 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000001446 217.0
HFD2_k127_6204613_81 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000002429 215.0
HFD2_k127_6204613_82 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000004055 201.0
HFD2_k127_6204613_83 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000002023 199.0
HFD2_k127_6204613_84 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000001036 193.0
HFD2_k127_6204613_85 EXOIII K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000152 200.0
HFD2_k127_6204613_86 - - - - 0.0000000000000000000000000000000000000000000000000002301 201.0
HFD2_k127_6204613_87 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000000000000000000000000000000002547 187.0
HFD2_k127_6204613_88 - - - - 0.0000000000000000000000000000000000000000000000000004364 197.0
HFD2_k127_6204613_89 Putative member of DMT superfamily (DUF486) K09922 - - 0.0000000000000000000000000000000000000000000000000004977 186.0
HFD2_k127_6204613_9 thiamine-containing compound biosynthetic process K02051 - - 2.088e-195 625.0
HFD2_k127_6204613_90 transport system K01992 - - 0.000000000000000000000000000000000000000000000000000716 210.0
HFD2_k127_6204613_91 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000001028 187.0
HFD2_k127_6204613_92 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000126 196.0
HFD2_k127_6204613_93 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000003933 192.0
HFD2_k127_6204613_94 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000443 193.0
HFD2_k127_6204613_95 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000003846 183.0
HFD2_k127_6204613_96 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000000004752 176.0
HFD2_k127_6204613_97 Met-10+ like-protein K02687 - - 0.000000000000000000000000000000000000000000000007827 182.0
HFD2_k127_6204613_98 - - - - 0.0000000000000000000000000000000000000000000000213 181.0
HFD2_k127_6204613_99 - - - - 0.00000000000000000000000000000000000000000000002342 179.0
HFD2_k127_621788_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001984 282.0
HFD2_k127_621788_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000278 246.0
HFD2_k127_621788_2 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000003815 150.0
HFD2_k127_621788_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000007175 123.0
HFD2_k127_6230936_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1276.0
HFD2_k127_6230936_1 TonB dependent receptor K21573 - - 4.427e-303 964.0
HFD2_k127_6230936_10 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009197 261.0
HFD2_k127_6230936_11 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000841 230.0
HFD2_k127_6230936_12 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000001235 220.0
HFD2_k127_6230936_13 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000005604 210.0
HFD2_k127_6230936_14 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000001098 199.0
HFD2_k127_6230936_15 Putative lumazine-binding - - - 0.00000000000000000000000000000000000003135 148.0
HFD2_k127_6230936_16 Histidine kinase - - - 0.00000000000000000000000000000000000006892 146.0
HFD2_k127_6230936_17 COG4635 Flavodoxin K00230 - 1.3.5.3 0.000000000000000000000000000000000008455 145.0
HFD2_k127_6230936_18 Protein of unknown function (DUF456) K09793 - - 0.0000000000000000000000000000001084 134.0
HFD2_k127_6230936_19 Protein of unknown function (DUF1634) - - - 0.000000000000000000000007932 105.0
HFD2_k127_6230936_2 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 617.0
HFD2_k127_6230936_20 PFAM ABC-2 type transporter K01992 - - 0.000000000000001683 81.0
HFD2_k127_6230936_21 Domain of unknown function (DUF4342) - - - 0.0000000000001062 75.0
HFD2_k127_6230936_3 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 610.0
HFD2_k127_6230936_4 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 546.0
HFD2_k127_6230936_5 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 504.0
HFD2_k127_6230936_6 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 446.0
HFD2_k127_6230936_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 424.0
HFD2_k127_6230936_8 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 368.0
HFD2_k127_6230936_9 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18302 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004132 276.0
HFD2_k127_6231111_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 612.0
HFD2_k127_6231111_1 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 493.0
HFD2_k127_6231111_10 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000002053 239.0
HFD2_k127_6231111_11 - - - - 0.000000000000000000000000000000000000000000000000000000000419 213.0
HFD2_k127_6231111_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000002329 201.0
HFD2_k127_6231111_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000001408 190.0
HFD2_k127_6231111_14 Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000002046 127.0
HFD2_k127_6231111_15 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000002403 96.0
HFD2_k127_6231111_16 - - - - 0.000000000000000009098 91.0
HFD2_k127_6231111_2 Mo-molybdopterin cofactor metabolic process K03148,K03636,K21029,K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.73,2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 494.0
HFD2_k127_6231111_3 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 466.0
HFD2_k127_6231111_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 453.0
HFD2_k127_6231111_5 Glycosyltransferase Family 4 K14335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 408.0
HFD2_k127_6231111_6 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 307.0
HFD2_k127_6231111_7 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004914 273.0
HFD2_k127_6231111_8 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001335 281.0
HFD2_k127_6231111_9 KR domain K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000003094 259.0
HFD2_k127_6238385_0 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000000000000000008589 199.0
HFD2_k127_6238385_1 Alpha amylase catalytic - - - 0.000000000000000000000000000000000000000000000387 168.0
HFD2_k127_6238385_3 response to pH - - - 0.0000000000000000000000006407 107.0
HFD2_k127_6238385_4 Transposase, Mutator family - - - 0.0000000000000000000005065 103.0
HFD2_k127_6240041_0 fatty acid desaturase K00508 - 1.14.19.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 533.0
HFD2_k127_6240041_1 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 366.0
HFD2_k127_6258619_0 GIY-YIG type nucleases (URI domain) K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001345 267.0
HFD2_k127_6310862_0 PFAM Mechanosensitive ion channel K03442 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 334.0
HFD2_k127_6310862_1 Cytochrome c K00413 - - 0.0000000000000000000000000000000000000000000000000000001331 205.0
HFD2_k127_6335119_0 protein kinase activity - - - 6.466e-195 639.0
HFD2_k127_6335119_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 481.0
HFD2_k127_6335119_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 434.0
HFD2_k127_6335119_3 Late embryogenesis abundant protein - - - 0.0000000000000000001101 97.0
HFD2_k127_6344112_0 cellulose binding - - - 1.963e-214 670.0
HFD2_k127_6344112_1 Belongs to the sigma-70 factor family. ECF subfamily - - - 9.862e-202 637.0
HFD2_k127_6344112_10 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006328 298.0
HFD2_k127_6344112_11 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 314.0
HFD2_k127_6344112_12 AlkA N-terminal domain K13529 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000228 243.0
HFD2_k127_6344112_13 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000729 228.0
HFD2_k127_6344112_14 antisigma factor binding K04749,K04757 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000001323 236.0
HFD2_k127_6344112_15 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000005976 205.0
HFD2_k127_6344112_16 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000007905 202.0
HFD2_k127_6344112_17 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000001888 202.0
HFD2_k127_6344112_18 saccharopine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000007014 193.0
HFD2_k127_6344112_19 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000008428 176.0
HFD2_k127_6344112_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 633.0
HFD2_k127_6344112_20 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.0000000000000000000000000000000000000002919 151.0
HFD2_k127_6344112_21 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000005091 155.0
HFD2_k127_6344112_23 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000001422 148.0
HFD2_k127_6344112_24 Peptidase family M1 domain K01256 - 3.4.11.2 0.00000000000000009425 96.0
HFD2_k127_6344112_25 Protein kinase domain K12132 - 2.7.11.1 0.0000000008562 66.0
HFD2_k127_6344112_26 Copper resistance protein D K07245 - - 0.0000004861 62.0
HFD2_k127_6344112_28 DinB superfamily - - - 0.00007869 51.0
HFD2_k127_6344112_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 512.0
HFD2_k127_6344112_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 483.0
HFD2_k127_6344112_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 438.0
HFD2_k127_6344112_6 transmembrane transporter activity K03535,K08194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 434.0
HFD2_k127_6344112_7 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 427.0
HFD2_k127_6344112_8 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 377.0
HFD2_k127_6344112_9 ATPases associated with a variety of cellular activities K05833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 302.0
HFD2_k127_6399271_0 Homeodomain-like domain K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 446.0
HFD2_k127_6453530_0 transmembrane transporter activity K18138 - - 0.0 1626.0
HFD2_k127_6453530_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 6.926e-292 911.0
HFD2_k127_6453530_10 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 341.0
HFD2_k127_6453530_11 Bacterial extracellular solute-binding protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 344.0
HFD2_k127_6453530_12 inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 337.0
HFD2_k127_6453530_13 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 331.0
HFD2_k127_6453530_14 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000007972 254.0
HFD2_k127_6453530_15 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000055 240.0
HFD2_k127_6453530_16 NmrA-like family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000001742 209.0
HFD2_k127_6453530_17 MarR family transcriptional regulator - - - 0.00000000000000000000000000000000000000000003162 175.0
HFD2_k127_6453530_18 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000003733 162.0
HFD2_k127_6453530_2 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 504.0
HFD2_k127_6453530_20 MerR, DNA binding K19591 - - 0.000000000000000000000000000000002206 136.0
HFD2_k127_6453530_21 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000007386 130.0
HFD2_k127_6453530_22 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000002713 117.0
HFD2_k127_6453530_23 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000008177 108.0
HFD2_k127_6453530_24 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000004675 103.0
HFD2_k127_6453530_25 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000000002426 84.0
HFD2_k127_6453530_26 PAP2 superfamily - - - 0.00000000002538 74.0
HFD2_k127_6453530_27 twin-arginine translocation pathway signal sequence domain protein - - - 0.0000000006641 68.0
HFD2_k127_6453530_28 Protein of unknown function (DUF1059) - - - 0.000000001432 63.0
HFD2_k127_6453530_29 Domain of Unknown function (DUF542) K07322 - - 0.0000004965 54.0
HFD2_k127_6453530_3 Cys/Met metabolism PLP-dependent enzyme K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 488.0
HFD2_k127_6453530_4 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 455.0
HFD2_k127_6453530_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 442.0
HFD2_k127_6453530_6 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 415.0
HFD2_k127_6453530_7 efflux transmembrane transporter activity K18300,K18308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 404.0
HFD2_k127_6453530_8 COG0500 SAM-dependent methyltransferases K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000924 381.0
HFD2_k127_6453530_9 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 366.0
HFD2_k127_6463254_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 1.993e-220 693.0
HFD2_k127_6463254_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 6.008e-213 692.0
HFD2_k127_6463254_10 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007827 288.0
HFD2_k127_6463254_11 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000296 278.0
HFD2_k127_6463254_12 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001943 278.0
HFD2_k127_6463254_13 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008087 267.0
HFD2_k127_6463254_14 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000072 254.0
HFD2_k127_6463254_15 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000005027 234.0
HFD2_k127_6463254_16 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000000000000000000000000000000000012 199.0
HFD2_k127_6463254_17 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000001438 126.0
HFD2_k127_6463254_19 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000015 105.0
HFD2_k127_6463254_2 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 561.0
HFD2_k127_6463254_20 - - - - 0.000000000000000000006974 96.0
HFD2_k127_6463254_21 Zincin-like metallopeptidase - - - 0.00000000000000000001846 100.0
HFD2_k127_6463254_22 - - - - 0.000000004038 64.0
HFD2_k127_6463254_23 Type II transport protein GspH K08084 - - 0.0000007557 60.0
HFD2_k127_6463254_24 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000001178 56.0
HFD2_k127_6463254_25 Methenyltetrahydrofolate cyclohydrolase - - - 0.000004603 51.0
HFD2_k127_6463254_26 protein secretion K02460 - - 0.00007577 56.0
HFD2_k127_6463254_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 558.0
HFD2_k127_6463254_4 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008948 570.0
HFD2_k127_6463254_5 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 444.0
HFD2_k127_6463254_6 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 402.0
HFD2_k127_6463254_7 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005161 400.0
HFD2_k127_6463254_8 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 333.0
HFD2_k127_6463254_9 Arac family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 300.0
HFD2_k127_6477070_0 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009733 297.0
HFD2_k127_6512686_0 Cystathionine beta-synthase K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 485.0
HFD2_k127_6512686_1 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 447.0
HFD2_k127_6512686_2 Pfam Aminotransferase class I and II K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 385.0
HFD2_k127_6512686_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 308.0
HFD2_k127_6512686_4 - - - - 0.00000000000005938 78.0
HFD2_k127_6512686_5 domain protein K13735 - - 0.0000000000004006 80.0
HFD2_k127_6512686_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000002188 56.0
HFD2_k127_6517414_0 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 0.0 1109.0
HFD2_k127_6517414_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 601.0
HFD2_k127_6517414_10 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 377.0
HFD2_k127_6517414_11 Trypsin K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 377.0
HFD2_k127_6517414_12 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 329.0
HFD2_k127_6517414_13 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 316.0
HFD2_k127_6517414_14 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 307.0
HFD2_k127_6517414_15 3-methyl-2-oxobutanoate hydroxymethyltransferase activity K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 288.0
HFD2_k127_6517414_16 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006793 287.0
HFD2_k127_6517414_17 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 271.0
HFD2_k127_6517414_18 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000004814 249.0
HFD2_k127_6517414_19 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000006168 225.0
HFD2_k127_6517414_2 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 591.0
HFD2_k127_6517414_20 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000007439 224.0
HFD2_k127_6517414_21 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000002052 218.0
HFD2_k127_6517414_22 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000007201 204.0
HFD2_k127_6517414_23 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000000000000003455 148.0
HFD2_k127_6517414_24 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.0000000000000000000000000000000000007354 147.0
HFD2_k127_6517414_25 TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.00000000000000000000000004631 121.0
HFD2_k127_6517414_26 PFAM regulatory protein, MarR - - - 0.0000000000000000000000008488 108.0
HFD2_k127_6517414_27 Chemotaxis sensory transducer K03406 - - 0.0000000000000000000001123 115.0
HFD2_k127_6517414_28 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000007057 93.0
HFD2_k127_6517414_29 acetyltransferase - - - 0.00000000000000002928 90.0
HFD2_k127_6517414_3 PFAM aminotransferase class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 569.0
HFD2_k127_6517414_30 PFAM Cell envelope-related transcriptional attenuator domain - - - 0.00001025 54.0
HFD2_k127_6517414_4 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 562.0
HFD2_k127_6517414_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 - 6.2.1.5,6.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009483 570.0
HFD2_k127_6517414_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902,K08692 - 6.2.1.5,6.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 463.0
HFD2_k127_6517414_7 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 458.0
HFD2_k127_6517414_8 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 458.0
HFD2_k127_6517414_9 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 395.0
HFD2_k127_6528508_0 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001213 276.0
HFD2_k127_6528508_1 Winged helix-turn helix - - - 0.000000000000000000000000000000000000000000000003843 184.0
HFD2_k127_6528508_2 - - - - 0.0000000005405 62.0
HFD2_k127_6571956_0 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 596.0
HFD2_k127_6571956_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 529.0
HFD2_k127_6571956_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 326.0
HFD2_k127_6571956_3 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000000000000000000000000000000000000002666 219.0
HFD2_k127_6571956_4 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.00000000000000000000000000000000002068 139.0
HFD2_k127_6571956_5 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000006929 116.0
HFD2_k127_6571956_6 protein kinase related protein - - - 0.00000004744 66.0
HFD2_k127_6588645_0 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000001135 275.0
HFD2_k127_6588645_1 Pfam Transposase IS66 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001064 244.0
HFD2_k127_6630718_0 AMP-binding enzyme C-terminal domain K01907 - 6.2.1.16 4.273e-264 833.0
HFD2_k127_6630718_1 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 4.171e-237 735.0
HFD2_k127_6630718_10 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000001536 109.0
HFD2_k127_6630718_11 Modulates RecA activity K03565 - - 0.000000000001993 76.0
HFD2_k127_6630718_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 1.458e-230 743.0
HFD2_k127_6630718_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 556.0
HFD2_k127_6630718_4 Fumarylacetoacetate (FAA) hydrolase K01555 - 3.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003295 556.0
HFD2_k127_6630718_5 Phenylalanine-4-hydroxylase K00500 GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007809 413.0
HFD2_k127_6630718_6 asparaginase activity K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000004527 263.0
HFD2_k127_6630718_7 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000005904 261.0
HFD2_k127_6630718_8 histidine-tRNA ligase activity K01892,K02502 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000001207 226.0
HFD2_k127_6630718_9 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000002952 190.0
HFD2_k127_6659217_0 PFAM Integrase catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 582.0
HFD2_k127_6659217_1 IstB-like ATP binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 302.0
HFD2_k127_6659217_2 Nacht domain - - - 0.00007475 49.0
HFD2_k127_6660440_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 9.828e-278 871.0
HFD2_k127_6660440_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.912e-240 750.0
HFD2_k127_6660440_10 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 451.0
HFD2_k127_6660440_11 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 412.0
HFD2_k127_6660440_12 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 409.0
HFD2_k127_6660440_13 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 429.0
HFD2_k127_6660440_14 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 398.0
HFD2_k127_6660440_15 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 398.0
HFD2_k127_6660440_16 amino acid K03294,K20265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 389.0
HFD2_k127_6660440_17 Putative RNA methylase family UPF0020 K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 384.0
HFD2_k127_6660440_18 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 391.0
HFD2_k127_6660440_19 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007355 379.0
HFD2_k127_6660440_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 2.486e-213 673.0
HFD2_k127_6660440_20 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 344.0
HFD2_k127_6660440_21 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 343.0
HFD2_k127_6660440_22 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 324.0
HFD2_k127_6660440_23 Integral membrane protein TerC family K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 323.0
HFD2_k127_6660440_24 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 330.0
HFD2_k127_6660440_25 peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 321.0
HFD2_k127_6660440_26 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 316.0
HFD2_k127_6660440_27 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 308.0
HFD2_k127_6660440_28 Electron transfer flavoprotein domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 306.0
HFD2_k127_6660440_29 Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 305.0
HFD2_k127_6660440_3 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 8.583e-210 668.0
HFD2_k127_6660440_30 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 321.0
HFD2_k127_6660440_31 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 287.0
HFD2_k127_6660440_32 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000437 298.0
HFD2_k127_6660440_33 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 288.0
HFD2_k127_6660440_34 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002213 281.0
HFD2_k127_6660440_35 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000726 303.0
HFD2_k127_6660440_36 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008483 280.0
HFD2_k127_6660440_37 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008612 267.0
HFD2_k127_6660440_38 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009855 265.0
HFD2_k127_6660440_39 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000001175 251.0
HFD2_k127_6660440_4 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 607.0
HFD2_k127_6660440_40 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000832 230.0
HFD2_k127_6660440_41 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000004706 226.0
HFD2_k127_6660440_42 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000001163 214.0
HFD2_k127_6660440_43 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000003877 219.0
HFD2_k127_6660440_44 esterase - - - 0.000000000000000000000000000000000000000000000000000000000009182 224.0
HFD2_k127_6660440_45 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000004212 213.0
HFD2_k127_6660440_46 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000004015 207.0
HFD2_k127_6660440_47 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000001912 188.0
HFD2_k127_6660440_48 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000009218 196.0
HFD2_k127_6660440_49 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000002932 187.0
HFD2_k127_6660440_5 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007855 611.0
HFD2_k127_6660440_50 SprT-like family - - - 0.0000000000000000000000000000000000000000001911 169.0
HFD2_k127_6660440_51 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000001615 160.0
HFD2_k127_6660440_52 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0000000000000000000000000000000000002569 156.0
HFD2_k127_6660440_53 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000002973 147.0
HFD2_k127_6660440_54 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000003094 145.0
HFD2_k127_6660440_55 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000002938 143.0
HFD2_k127_6660440_56 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000009659 146.0
HFD2_k127_6660440_57 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000009472 135.0
HFD2_k127_6660440_58 4 iron, 4 sulfur cluster binding K02573 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000001104 130.0
HFD2_k127_6660440_59 coa-binding K06929 - - 0.00000000000000000000000000001861 131.0
HFD2_k127_6660440_6 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 624.0
HFD2_k127_6660440_60 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000002758 134.0
HFD2_k127_6660440_61 Thioredoxin-like domain K03671 - - 0.00000000000000000000000001431 112.0
HFD2_k127_6660440_62 COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000001077 110.0
HFD2_k127_6660440_63 NnrU protein - - - 0.0000000000000000000001906 106.0
HFD2_k127_6660440_64 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000004564 90.0
HFD2_k127_6660440_65 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000008754 98.0
HFD2_k127_6660440_66 - - - - 0.000000000000000001512 96.0
HFD2_k127_6660440_67 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000001552 93.0
HFD2_k127_6660440_68 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000003913 95.0
HFD2_k127_6660440_69 peptidyl-tyrosine sulfation - - - 0.000000000000001642 90.0
HFD2_k127_6660440_7 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 570.0
HFD2_k127_6660440_70 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000009422 78.0
HFD2_k127_6660440_71 - - - - 0.0000000000002965 77.0
HFD2_k127_6660440_72 D-alanyl-D-alanine carboxypeptidase K17733 - - 0.000000000004912 76.0
HFD2_k127_6660440_73 Domain of unknown function (DUF4157) - - - 0.000000000006591 76.0
HFD2_k127_6660440_74 Selenoprotein, putative - - - 0.0000000002724 65.0
HFD2_k127_6660440_75 - - - - 0.0000000462 64.0
HFD2_k127_6660440_77 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000002119 61.0
HFD2_k127_6660440_78 - - - - 0.00004705 51.0
HFD2_k127_6660440_8 Major facilitator K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 509.0
HFD2_k127_6660440_9 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 486.0
HFD2_k127_6734940_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 8e-323 1019.0
HFD2_k127_6734940_1 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00146,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85 2.849e-233 731.0
HFD2_k127_6734940_10 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 352.0
HFD2_k127_6734940_11 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 349.0
HFD2_k127_6734940_12 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 333.0
HFD2_k127_6734940_13 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 306.0
HFD2_k127_6734940_14 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 312.0
HFD2_k127_6734940_15 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001229 285.0
HFD2_k127_6734940_16 PFAM binding-protein-dependent transport systems inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 270.0
HFD2_k127_6734940_17 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006566 255.0
HFD2_k127_6734940_18 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K00982,K03564 - 1.11.1.15,2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000002294 210.0
HFD2_k127_6734940_19 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000006802 218.0
HFD2_k127_6734940_2 FAD dependent oxidoreductase - - - 3.932e-231 726.0
HFD2_k127_6734940_20 Copper amine oxidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000001113 184.0
HFD2_k127_6734940_21 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000006823 171.0
HFD2_k127_6734940_22 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000004124 170.0
HFD2_k127_6734940_23 - - - - 0.000000000000000000000000000000000005017 145.0
HFD2_k127_6734940_24 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000002644 121.0
HFD2_k127_6734940_25 domain, Protein K00869,K00938,K01081,K07004,K17624 - 2.7.1.36,2.7.4.2,3.1.3.5,3.2.1.97 0.0000000000000000000189 109.0
HFD2_k127_6734940_26 His Kinase A (phosphoacceptor) domain - - - 0.00000000002797 71.0
HFD2_k127_6734940_27 - - - - 0.000000000226 71.0
HFD2_k127_6734940_28 cellulose binding - - - 0.000000319 66.0
HFD2_k127_6734940_29 deoxyhypusine monooxygenase activity - - - 0.000002782 60.0
HFD2_k127_6734940_3 Aminotransferase class-III - - - 9.385e-201 634.0
HFD2_k127_6734940_30 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000006523 61.0
HFD2_k127_6734940_4 Reductase C-terminal K05297 - 1.18.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 612.0
HFD2_k127_6734940_5 Aminotransferase class-III K09251 - 2.6.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 530.0
HFD2_k127_6734940_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 486.0
HFD2_k127_6734940_7 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 448.0
HFD2_k127_6734940_8 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 354.0
HFD2_k127_6734940_9 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 353.0
HFD2_k127_673877_0 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007978 269.0
HFD2_k127_673877_1 Carboxypeptidase regulatory-like domain - - - 0.000000000000003659 91.0
HFD2_k127_673877_2 - K07004 - - 0.00009502 54.0
HFD2_k127_673877_3 - - - - 0.0003759 49.0
HFD2_k127_673877_4 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.0005525 51.0
HFD2_k127_673877_5 VanZ like family - - - 0.000561 52.0
HFD2_k127_6780270_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.08e-319 1005.0
HFD2_k127_6780270_1 Uncharacterized protein family (UPF0051) K09014 - - 1.822e-263 818.0
HFD2_k127_6780270_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 544.0
HFD2_k127_6780270_100 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000007806 98.0
HFD2_k127_6780270_101 Stress-responsive transcriptional regulator K03973 - - 0.0000000000000000002629 88.0
HFD2_k127_6780270_102 Matrixin - - - 0.000000000000000001243 96.0
HFD2_k127_6780270_103 - - - - 0.000000000000000003265 99.0
HFD2_k127_6780270_104 Sporulation related domain - - - 0.0000000000000002547 89.0
HFD2_k127_6780270_105 Ribosomal protein L34 K02914 - - 0.0000000000000006062 78.0
HFD2_k127_6780270_107 - - - - 0.0000000000000677 83.0
HFD2_k127_6780270_108 PFAM Copper resistance protein CopC K07156 - - 0.00000000003061 69.0
HFD2_k127_6780270_11 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009897 550.0
HFD2_k127_6780270_110 - - - - 0.00000000006492 72.0
HFD2_k127_6780270_111 copper resistance D domain protein K14166 - - 0.00000000007916 73.0
HFD2_k127_6780270_112 BFD-like [2Fe-2S] binding domain - - - 0.0000000001664 63.0
HFD2_k127_6780270_114 - - - - 0.0000000003881 66.0
HFD2_k127_6780270_115 Copper chaperone PCu(A)C K09796 - - 0.0000000004148 69.0
HFD2_k127_6780270_116 SnoaL-like domain - - - 0.000000003289 68.0
HFD2_k127_6780270_117 PFAM Archaeal ATPase K03709,K06921 - - 0.000000009145 66.0
HFD2_k127_6780270_118 Ferredoxin K05337 - - 0.00000003119 59.0
HFD2_k127_6780270_119 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000004834 61.0
HFD2_k127_6780270_12 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 548.0
HFD2_k127_6780270_120 Polymer-forming cytoskeletal - - - 0.00000005622 61.0
HFD2_k127_6780270_121 ketosteroid isomerase - - - 0.000001971 57.0
HFD2_k127_6780270_123 signal transduction histidine kinase - - - 0.000007026 59.0
HFD2_k127_6780270_124 Domain of Unknown Function (DUF350) - - - 0.000008642 52.0
HFD2_k127_6780270_125 Sodium:solute symporter family K14393 - - 0.0001381 55.0
HFD2_k127_6780270_13 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 511.0
HFD2_k127_6780270_14 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006728 502.0
HFD2_k127_6780270_15 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009609 496.0
HFD2_k127_6780270_16 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 513.0
HFD2_k127_6780270_17 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 415.0
HFD2_k127_6780270_18 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 407.0
HFD2_k127_6780270_19 phosphorelay signal transduction system K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009282 413.0
HFD2_k127_6780270_2 GMC oxidoreductase - - - 1.052e-251 790.0
HFD2_k127_6780270_20 ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 414.0
HFD2_k127_6780270_21 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 405.0
HFD2_k127_6780270_22 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 396.0
HFD2_k127_6780270_23 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 385.0
HFD2_k127_6780270_24 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 377.0
HFD2_k127_6780270_25 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 395.0
HFD2_k127_6780270_26 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 387.0
HFD2_k127_6780270_27 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 375.0
HFD2_k127_6780270_28 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007235 382.0
HFD2_k127_6780270_29 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 361.0
HFD2_k127_6780270_3 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.173e-230 742.0
HFD2_k127_6780270_30 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008817 364.0
HFD2_k127_6780270_31 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 359.0
HFD2_k127_6780270_32 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 361.0
HFD2_k127_6780270_33 Zn-dependent protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 344.0
HFD2_k127_6780270_34 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01476,K01480 GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 3.5.3.1,3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009593 343.0
HFD2_k127_6780270_35 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 321.0
HFD2_k127_6780270_36 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 317.0
HFD2_k127_6780270_37 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 306.0
HFD2_k127_6780270_38 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 300.0
HFD2_k127_6780270_39 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 298.0
HFD2_k127_6780270_4 abc transporter atp-binding protein K06147 - - 7.485e-216 692.0
HFD2_k127_6780270_40 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007905 287.0
HFD2_k127_6780270_41 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001347 295.0
HFD2_k127_6780270_42 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001835 296.0
HFD2_k127_6780270_43 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003001 272.0
HFD2_k127_6780270_44 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007344 272.0
HFD2_k127_6780270_45 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000669 261.0
HFD2_k127_6780270_46 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008895 261.0
HFD2_k127_6780270_47 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000003217 271.0
HFD2_k127_6780270_48 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001024 259.0
HFD2_k127_6780270_49 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004583 245.0
HFD2_k127_6780270_5 Bacterial transcriptional activator domain K12132 - 2.7.11.1 7.426e-204 679.0
HFD2_k127_6780270_50 ABC 3 transport family K02075,K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000006289 262.0
HFD2_k127_6780270_51 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000009127 240.0
HFD2_k127_6780270_52 Belongs to the GTP cyclohydrolase I type 2 NIF3 family K22391 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000001068 240.0
HFD2_k127_6780270_53 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001439 249.0
HFD2_k127_6780270_54 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000004939 235.0
HFD2_k127_6780270_55 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001742 237.0
HFD2_k127_6780270_56 cytochrome c oxidase K02351,K02862 - - 0.00000000000000000000000000000000000000000000000000000000004499 214.0
HFD2_k127_6780270_57 - - - - 0.00000000000000000000000000000000000000000000000000000000005938 223.0
HFD2_k127_6780270_58 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000008837 214.0
HFD2_k127_6780270_59 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000002765 212.0
HFD2_k127_6780270_6 elongation factor G K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007855 607.0
HFD2_k127_6780270_60 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000007968 202.0
HFD2_k127_6780270_61 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000000000000005904 196.0
HFD2_k127_6780270_62 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000001105 190.0
HFD2_k127_6780270_63 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000001195 199.0
HFD2_k127_6780270_64 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000000000000000000000001851 191.0
HFD2_k127_6780270_65 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000001126 195.0
HFD2_k127_6780270_66 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.00000000000000000000000000000000000000000000000003336 182.0
HFD2_k127_6780270_67 Belongs to the UPF0403 family - - - 0.00000000000000000000000000000000000000000000000006002 181.0
HFD2_k127_6780270_68 Copper chaperone PCu(A)C K03619,K07152,K09796 GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277 - 0.0000000000000000000000000000000000000000000000001444 184.0
HFD2_k127_6780270_69 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000002632 181.0
HFD2_k127_6780270_7 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 594.0
HFD2_k127_6780270_70 Squalene--hopene cyclase - - - 0.000000000000000000000000000000000000000000000000479 182.0
HFD2_k127_6780270_71 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000000000000000000000000003279 170.0
HFD2_k127_6780270_72 HTH domain - - - 0.00000000000000000000000000000000000000000001536 171.0
HFD2_k127_6780270_73 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000001427 177.0
HFD2_k127_6780270_74 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000002166 159.0
HFD2_k127_6780270_75 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000007246 153.0
HFD2_k127_6780270_76 Transcriptional regulator - - - 0.0000000000000000000000000000000000000005717 156.0
HFD2_k127_6780270_77 Tfp pilus assembly protein FimV K00694 - 2.4.1.12 0.00000000000000000000000000000000000000561 165.0
HFD2_k127_6780270_78 peptide deformylase activity K01462 - 3.5.1.88 0.000000000000000000000000000000000000009561 153.0
HFD2_k127_6780270_79 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000066 150.0
HFD2_k127_6780270_8 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 584.0
HFD2_k127_6780270_80 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000002126 153.0
HFD2_k127_6780270_81 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000004871 155.0
HFD2_k127_6780270_82 PFAM transposase mutator type K07493 - - 0.0000000000000000000000000000000001611 136.0
HFD2_k127_6780270_83 transcriptional - - - 0.000000000000000000000000000000001398 137.0
HFD2_k127_6780270_84 Rhomboid family - - - 0.000000000000000000000000000000003298 141.0
HFD2_k127_6780270_85 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.000000000000000000000000000000003571 142.0
HFD2_k127_6780270_86 - - - - 0.00000000000000000000000000000004222 137.0
HFD2_k127_6780270_87 Iron-sulfur cluster assembly protein - - - 0.00000000000000000000000000000006293 126.0
HFD2_k127_6780270_88 Clostripain family - - - 0.00000000000000000000000000000007073 145.0
HFD2_k127_6780270_89 - - - - 0.000000000000000000000000000000675 132.0
HFD2_k127_6780270_9 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 580.0
HFD2_k127_6780270_90 - - - - 0.0000000000000000000000000001405 126.0
HFD2_k127_6780270_91 Transglycosylase associated protein - - - 0.000000000000000000000000002366 114.0
HFD2_k127_6780270_92 - - - - 0.000000000000000000000000007361 119.0
HFD2_k127_6780270_93 PFAM Peptidase family M23 - - - 0.0000000000000000000000000256 122.0
HFD2_k127_6780270_94 Helix-turn-helix domain K07729 - - 0.00000000000000000000000003285 112.0
HFD2_k127_6780270_95 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000009036 115.0
HFD2_k127_6780270_98 Glyoxalase-like domain - - - 0.000000000000000000000009336 106.0
HFD2_k127_6780270_99 HxlR-like helix-turn-helix - - - 0.0000000000000000000000385 102.0
HFD2_k127_6783498_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 7.948e-232 737.0
HFD2_k127_6783498_1 Bacterial regulatory protein, Fis family - - - 6.611e-223 704.0
HFD2_k127_6783498_10 Nucleotidyl transferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 380.0
HFD2_k127_6783498_11 Methyltransferase domain protein K12710,K13317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 379.0
HFD2_k127_6783498_12 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 332.0
HFD2_k127_6783498_13 arylsulfatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 342.0
HFD2_k127_6783498_14 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 308.0
HFD2_k127_6783498_15 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 291.0
HFD2_k127_6783498_16 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009682 284.0
HFD2_k127_6783498_17 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005253 265.0
HFD2_k127_6783498_18 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000179 265.0
HFD2_k127_6783498_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003584 260.0
HFD2_k127_6783498_2 Flavin containing amine oxidoreductase K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 582.0
HFD2_k127_6783498_20 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000009603 244.0
HFD2_k127_6783498_21 PFAM metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000003691 234.0
HFD2_k127_6783498_22 involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000001096 229.0
HFD2_k127_6783498_23 - K14340 - - 0.0000000000000000000000000000000000000000000000000000000000006687 235.0
HFD2_k127_6783498_24 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000266 203.0
HFD2_k127_6783498_25 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000007417 192.0
HFD2_k127_6783498_26 Protein of unknown function (DUF3485) - - - 0.0000000000000000000000000000000000000000000000003163 183.0
HFD2_k127_6783498_27 sugar transferase - - - 0.0000000000000000000000000000000000000000000002069 177.0
HFD2_k127_6783498_28 lysyltransferase activity - - - 0.0000000000000000000000000000000000000000000002777 187.0
HFD2_k127_6783498_29 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000007938 175.0
HFD2_k127_6783498_3 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 598.0
HFD2_k127_6783498_30 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000004859 178.0
HFD2_k127_6783498_31 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.0000000000000000000000000000000000000002945 171.0
HFD2_k127_6783498_32 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000006097 157.0
HFD2_k127_6783498_33 polysaccharide export - - - 0.00000000000000000000000000009984 126.0
HFD2_k127_6783498_34 GGDEF domain - - - 0.000000000000000000000000002502 123.0
HFD2_k127_6783498_35 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000000000849 116.0
HFD2_k127_6783498_36 GDP-mannose 4,6 dehydratase K19180 - 1.1.1.339 0.00000000000000000000001372 114.0
HFD2_k127_6783498_37 - - - - 0.00000000000000002728 91.0
HFD2_k127_6783498_38 Large-conductance mechanosensitive channel, MscL K03282 - - 0.000000000000000072 93.0
HFD2_k127_6783498_39 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000004724 69.0
HFD2_k127_6783498_4 Beta-eliminating lyase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 546.0
HFD2_k127_6783498_41 Uncharacterized conserved protein (DUF2304) K09153 - - 0.0000000263 64.0
HFD2_k127_6783498_42 VanZ like family - - - 0.0000003927 62.0
HFD2_k127_6783498_43 PepSY-associated TM region - - - 0.000001127 59.0
HFD2_k127_6783498_5 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 486.0
HFD2_k127_6783498_6 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008838 424.0
HFD2_k127_6783498_7 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 410.0
HFD2_k127_6783498_8 PFAM NAD dependent epimerase dehydratase family K01709 - 4.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 414.0
HFD2_k127_6783498_9 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 409.0
HFD2_k127_6810957_0 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000003124 206.0
HFD2_k127_6810957_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000007168 95.0
HFD2_k127_6810957_2 - - - - 0.00001102 52.0
HFD2_k127_6810957_3 - - - - 0.0006086 52.0
HFD2_k127_68191_0 hydrolase activity, acting on ester bonds K07017 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 332.0
HFD2_k127_68191_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002439 280.0
HFD2_k127_68191_10 translation initiation inhibitor yjgF family - - - 0.00000000000000000000000000000000002236 146.0
HFD2_k127_68191_11 thiolester hydrolase activity - - - 0.00000000000000000000000000000000009284 139.0
HFD2_k127_68191_12 Predicted membrane protein (DUF2214) K08983 - - 0.0000000000000000000000000000000007399 137.0
HFD2_k127_68191_13 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000008845 137.0
HFD2_k127_68191_15 - - - - 0.0000000000000000000000000001256 124.0
HFD2_k127_68191_16 RibD C-terminal domain - - - 0.0000000000002487 80.0
HFD2_k127_68191_17 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000003591 69.0
HFD2_k127_68191_18 - - - - 0.000000000538 70.0
HFD2_k127_68191_2 glyoxalase K07032 - - 0.0000000000000000000000000000000000000000000000000000000000000000003709 231.0
HFD2_k127_68191_20 transcriptional regulator - - - 0.000001224 55.0
HFD2_k127_68191_21 - - - - 0.000001789 57.0
HFD2_k127_68191_22 ROK family - - - 0.000005306 55.0
HFD2_k127_68191_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000004431 208.0
HFD2_k127_68191_4 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000006587 195.0
HFD2_k127_68191_5 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000006836 199.0
HFD2_k127_68191_6 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000001784 188.0
HFD2_k127_68191_7 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000001626 182.0
HFD2_k127_68191_8 phosphinothricin N-acetyltransferase activity K01814,K03828 - 5.3.1.16 0.0000000000000000000000000000000000000000000001995 177.0
HFD2_k127_68191_9 - - - - 0.00000000000000000000000000000000000000008248 162.0
HFD2_k127_7134871_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1313.0
HFD2_k127_7134871_1 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 2.478e-255 805.0
HFD2_k127_7134871_10 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 373.0
HFD2_k127_7134871_11 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 347.0
HFD2_k127_7134871_12 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 342.0
HFD2_k127_7134871_13 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000002938 222.0
HFD2_k127_7134871_14 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.0000000000000000000000000000000000000000000000000000007934 205.0
HFD2_k127_7134871_15 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.00000000000000000000000000000000003847 141.0
HFD2_k127_7134871_16 - - - - 0.00000000000000000000000001021 121.0
HFD2_k127_7134871_17 Hydrogenase expression formation protein K04653 - - 0.0000000000000000000000001266 109.0
HFD2_k127_7134871_18 subunit of a heme lyase K02200 - - 0.00000000000000000000007127 111.0
HFD2_k127_7134871_19 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000208 94.0
HFD2_k127_7134871_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 4.524e-247 774.0
HFD2_k127_7134871_20 PFAM transglutaminase domain protein - - - 0.0000000000000006436 92.0
HFD2_k127_7134871_21 TPR repeat - - - 0.00000000000001088 83.0
HFD2_k127_7134871_22 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000001467 77.0
HFD2_k127_7134871_23 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000006037 64.0
HFD2_k127_7134871_24 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000001733 59.0
HFD2_k127_7134871_25 nickel cation binding K04651 - - 0.0000005211 57.0
HFD2_k127_7134871_26 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000009586 62.0
HFD2_k127_7134871_27 PFAM NHL repeat containing protein - - - 0.000001279 61.0
HFD2_k127_7134871_28 zinc-ribbon domain - - - 0.0001067 54.0
HFD2_k127_7134871_29 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0001506 51.0
HFD2_k127_7134871_3 Belongs to the carbamoyltransferase HypF family K04656 - - 3.309e-212 693.0
HFD2_k127_7134871_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 612.0
HFD2_k127_7134871_5 Hydrogenase formation hypA family K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 532.0
HFD2_k127_7134871_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 537.0
HFD2_k127_7134871_7 Putative ATP-binding cassette K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 519.0
HFD2_k127_7134871_8 small subunit K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 439.0
HFD2_k127_7134871_9 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 392.0
HFD2_k127_7306703_0 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1808.0
HFD2_k127_7306703_1 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 7.034e-286 895.0
HFD2_k127_7306703_10 Ammonium Transporter Family K03320 - - 7.145e-197 623.0
HFD2_k127_7306703_11 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.517e-194 631.0
HFD2_k127_7306703_12 Psort location CytoplasmicMembrane, score 10.00 K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 567.0
HFD2_k127_7306703_13 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 529.0
HFD2_k127_7306703_14 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 525.0
HFD2_k127_7306703_15 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 520.0
HFD2_k127_7306703_16 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 454.0
HFD2_k127_7306703_17 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 446.0
HFD2_k127_7306703_18 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 420.0
HFD2_k127_7306703_19 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 427.0
HFD2_k127_7306703_2 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 1.959e-284 885.0
HFD2_k127_7306703_20 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 384.0
HFD2_k127_7306703_21 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 386.0
HFD2_k127_7306703_22 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 378.0
HFD2_k127_7306703_23 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 348.0
HFD2_k127_7306703_24 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 340.0
HFD2_k127_7306703_25 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 351.0
HFD2_k127_7306703_26 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 329.0
HFD2_k127_7306703_27 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 325.0
HFD2_k127_7306703_28 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 308.0
HFD2_k127_7306703_29 Aconitase C-terminal domain K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000009173 251.0
HFD2_k127_7306703_3 Peptidase family M1 domain - - - 4.037e-275 859.0
HFD2_k127_7306703_30 IMS family HHH motif K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000001211 261.0
HFD2_k127_7306703_31 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000002967 263.0
HFD2_k127_7306703_32 Domain of unknown function (DUF3471) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006048 262.0
HFD2_k127_7306703_33 Nitrogen regulatory protein P-II K04751 - - 0.00000000000000000000000000000000000000000000000000000000133 204.0
HFD2_k127_7306703_34 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.000000000000000000000000000000000000000000000000000002535 200.0
HFD2_k127_7306703_35 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000007462 196.0
HFD2_k127_7306703_36 Iron-storage protein K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000002112 176.0
HFD2_k127_7306703_37 DoxX K15977 - - 0.000000000000000000000000000000000000000000002368 175.0
HFD2_k127_7306703_38 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000005496 175.0
HFD2_k127_7306703_39 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000003559 157.0
HFD2_k127_7306703_4 4Fe-4S dicluster domain K00184 - - 5.289e-235 761.0
HFD2_k127_7306703_40 transcriptional regulator - - - 0.000000000000000000000000000000000000004139 153.0
HFD2_k127_7306703_41 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000006391 151.0
HFD2_k127_7306703_42 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000006345 136.0
HFD2_k127_7306703_43 Diguanylate cyclase with PAS PAC and GAF sensors - - - 0.000000000000000000000000000000002785 145.0
HFD2_k127_7306703_44 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000002997 139.0
HFD2_k127_7306703_45 light absorption - - - 0.000000000000000000000000000000003712 134.0
HFD2_k127_7306703_46 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000007722 135.0
HFD2_k127_7306703_47 Ribonuclease B OB domain K03704 - - 0.000000000000000000000000000006836 123.0
HFD2_k127_7306703_48 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.000000000000000000000000000008982 130.0
HFD2_k127_7306703_49 ADP-ribosyl-(Dinitrogen reductase) hydrolase K05521 - 3.2.2.24 0.00000000000000000000000000001784 129.0
HFD2_k127_7306703_5 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K07027,K14205 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 4.176e-232 752.0
HFD2_k127_7306703_50 HD domain - - - 0.000000000000000000000000002203 119.0
HFD2_k127_7306703_51 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000221 118.0
HFD2_k127_7306703_52 ACT domain K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.00000000000000000003713 104.0
HFD2_k127_7306703_53 Cytochrome c - - - 0.00000000000000000116 94.0
HFD2_k127_7306703_55 Putative stress-induced transcription regulator - - - 0.00000000004131 70.0
HFD2_k127_7306703_56 Forkhead associated domain - - - 0.000000003816 68.0
HFD2_k127_7306703_57 - - - - 0.00000003731 65.0
HFD2_k127_7306703_6 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 3.024e-223 702.0
HFD2_k127_7306703_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.44e-219 688.0
HFD2_k127_7306703_8 Acyl-CoA dehydrogenase, N-terminal domain - - - 2.353e-217 691.0
HFD2_k127_7306703_9 Thiamine pyrophosphate protein TPP binding domain protein K01652 - 2.2.1.6 1.064e-213 677.0
HFD2_k127_7316787_0 ATP-grasp domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 351.0
HFD2_k127_7316787_1 Belongs to the glycosyl hydrolase 32 family K01193 - 3.2.1.26 0.00000000000000002524 96.0
HFD2_k127_7316787_2 - - - - 0.000000000000001678 89.0
HFD2_k127_7316787_3 GDSL-like Lipase/Acylhydrolase - - - 0.00000007147 65.0
HFD2_k127_7316787_4 - - - - 0.00006862 55.0
HFD2_k127_7325381_0 Carbohydrate family 9 binding domain-like - - - 0.0 1017.0
HFD2_k127_7325381_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 1.089e-218 688.0
HFD2_k127_7325381_10 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 369.0
HFD2_k127_7325381_11 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 366.0
HFD2_k127_7325381_12 mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 335.0
HFD2_k127_7325381_13 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002319 276.0
HFD2_k127_7325381_14 SCP-2 sterol transfer family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001742 263.0
HFD2_k127_7325381_15 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001415 259.0
HFD2_k127_7325381_16 Leishmanolysin - - - 0.0000000000000000000000000000000000000000000000000000000002744 222.0
HFD2_k127_7325381_17 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.00000000000000000000000000000000000000000000000000000001047 214.0
HFD2_k127_7325381_18 - - - - 0.000000000000000000000000000000000000000000001385 171.0
HFD2_k127_7325381_19 PFAM Fe-S metabolism associated K02426 - - 0.000000000000000000000000000000004474 136.0
HFD2_k127_7325381_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 2.463e-209 656.0
HFD2_k127_7325381_20 COG2206 HD-GYP domain - - - 0.00000000000000000000004225 113.0
HFD2_k127_7325381_21 PBS lyase HEAT-like repeat - - - 0.00002089 57.0
HFD2_k127_7325381_22 - - - - 0.0003955 50.0
HFD2_k127_7325381_23 domain protein - - - 0.0009013 51.0
HFD2_k127_7325381_3 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 568.0
HFD2_k127_7325381_4 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 574.0
HFD2_k127_7325381_5 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 561.0
HFD2_k127_7325381_6 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 565.0
HFD2_k127_7325381_7 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 554.0
HFD2_k127_7325381_8 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 442.0
HFD2_k127_7325381_9 PFAM sulfatase K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 428.0
HFD2_k127_7333868_0 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 8.395e-235 759.0
HFD2_k127_7333868_1 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 568.0
HFD2_k127_7333868_2 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 452.0
HFD2_k127_7333868_3 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 402.0
HFD2_k127_7333868_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003077 258.0
HFD2_k127_7333868_5 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000603 227.0
HFD2_k127_7333868_6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000004862 153.0
HFD2_k127_7333868_7 Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis K06208 - 5.4.99.5 0.0000000000000000000000000000000002274 141.0
HFD2_k127_7357503_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000002518 209.0
HFD2_k127_7357503_1 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000003365 198.0
HFD2_k127_7357503_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000001751 190.0
HFD2_k127_7357503_3 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.0000000000000000000000000000000000001825 142.0
HFD2_k127_7357503_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000001095 111.0
HFD2_k127_7357503_6 ATP dependent DNA ligase domain protein - - - 0.0000000000002312 73.0
HFD2_k127_7357503_7 SprB repeat - - - 0.00003448 57.0
HFD2_k127_7379460_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1174.0
HFD2_k127_7379460_1 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 450.0
HFD2_k127_7379460_2 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 321.0
HFD2_k127_7379460_3 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001406 272.0
HFD2_k127_7379460_4 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000007296 260.0
HFD2_k127_7379460_5 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000002166 231.0
HFD2_k127_7379460_6 Phosphodiester glycosidase - - - 0.00000000000000000000000000000000000000000000000002677 194.0
HFD2_k127_7379460_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000004583 186.0
HFD2_k127_7379460_8 Stress responsive - - - 0.00000002209 60.0
HFD2_k127_7400220_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 534.0
HFD2_k127_7400220_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 433.0
HFD2_k127_7400220_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 443.0
HFD2_k127_7400220_3 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 374.0
HFD2_k127_7400220_4 GlcNAc-PI de-N-acetylase K01463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 295.0
HFD2_k127_7400220_5 extracellular polysaccharide biosynthetic process K13582 - - 0.00000000000000000000000000000000000000000000000000000000000000007093 236.0
HFD2_k127_7400220_6 Prolyl oligopeptidase family - - - 0.000000000000000000000000000001326 139.0
HFD2_k127_7662646_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1571.0
HFD2_k127_7662646_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 432.0
HFD2_k127_7662646_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007419 247.0
HFD2_k127_7662646_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00002357 51.0
HFD2_k127_7768391_0 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 376.0
HFD2_k127_7768391_1 domain protein K13735 - - 0.0000000000000000000000000000000000000000000000001735 201.0
HFD2_k127_7768391_2 SURF1 family K14998 - - 0.000000000000000000000000000000000005205 147.0
HFD2_k127_7890066_0 lipopolysaccharide transport K22110 - - 0.0 1220.0
HFD2_k127_7890066_1 Collagenase K08303 - - 0.0 1084.0
HFD2_k127_7890066_10 Beta-lactamase class C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 423.0
HFD2_k127_7890066_11 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 404.0
HFD2_k127_7890066_12 TIGRFAM rhamnulose-1-phosphate aldolase alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009895 385.0
HFD2_k127_7890066_13 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 366.0
HFD2_k127_7890066_14 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 347.0
HFD2_k127_7890066_15 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 342.0
HFD2_k127_7890066_16 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 333.0
HFD2_k127_7890066_17 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 356.0
HFD2_k127_7890066_18 glycosyl transferase family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 300.0
HFD2_k127_7890066_19 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000007122 271.0
HFD2_k127_7890066_2 trehalose biosynthetic process K00700,K05343,K16146 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 4.879e-309 952.0
HFD2_k127_7890066_20 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000001259 253.0
HFD2_k127_7890066_21 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001358 236.0
HFD2_k127_7890066_22 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000005293 225.0
HFD2_k127_7890066_23 - - - - 0.000000000000000000000000000000000000000000000000000000000007299 212.0
HFD2_k127_7890066_25 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000007181 212.0
HFD2_k127_7890066_26 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000000001767 201.0
HFD2_k127_7890066_27 actin binding - - - 0.000000000000000000000000000000000000000000000002306 180.0
HFD2_k127_7890066_3 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.089e-286 891.0
HFD2_k127_7890066_30 response to cobalt ion - - - 0.000000000000000000003858 98.0
HFD2_k127_7890066_31 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000002057 73.0
HFD2_k127_7890066_4 GMC oxidoreductase - - - 8.104e-280 870.0
HFD2_k127_7890066_5 Alpha-L-fucosidase K01206 - 3.2.1.51 2.28e-206 649.0
HFD2_k127_7890066_6 M61 glycyl aminopeptidase - - - 4.018e-203 651.0
HFD2_k127_7890066_7 Oxidoreductase family, NAD-binding Rossmann fold - - - 1.563e-196 623.0
HFD2_k127_7890066_8 Multicopper oxidase K00368,K22348 - 1.16.3.3,1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 453.0
HFD2_k127_7890066_9 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 439.0
HFD2_k127_7914263_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 542.0
HFD2_k127_7914263_1 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K01992,K07027,K14205 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 460.0
HFD2_k127_7914263_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000002805 194.0
HFD2_k127_7914263_3 LysM domain K08307,K12204 - - 0.000000000000000000000000001949 128.0
HFD2_k127_7914263_4 nuclear chromosome segregation - - - 0.0000000000000000000002787 108.0
HFD2_k127_7920572_0 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 5.673e-256 802.0
HFD2_k127_7920572_1 Carboxyl transferase domain - - - 1.108e-232 732.0
HFD2_k127_7920572_10 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 408.0
HFD2_k127_7920572_11 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 393.0
HFD2_k127_7920572_12 Bacterial regulatory protein, Fis family K07713 GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 379.0
HFD2_k127_7920572_13 RecQ zinc-binding K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 347.0
HFD2_k127_7920572_14 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 334.0
HFD2_k127_7920572_15 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 304.0
HFD2_k127_7920572_16 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 316.0
HFD2_k127_7920572_17 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002318 297.0
HFD2_k127_7920572_18 7TM receptor with intracellular HD hydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006495 273.0
HFD2_k127_7920572_19 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000113 224.0
HFD2_k127_7920572_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 4.325e-217 693.0
HFD2_k127_7920572_20 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000000000000000000000000000000000000000000000002234 203.0
HFD2_k127_7920572_21 Belongs to the enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.0000000000000000000000000000000000000000000000001709 186.0
HFD2_k127_7920572_22 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000002585 174.0
HFD2_k127_7920572_23 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000003442 176.0
HFD2_k127_7920572_24 - - - - 0.0000000000000000000000000000000000000000009653 160.0
HFD2_k127_7920572_25 COGs COG1253 Hemolysins and related protein containing CBS domains - - - 0.00000000000000000000000000000000000000006888 169.0
HFD2_k127_7920572_26 Histidine kinase - - - 0.000000000000000000000000000000002113 147.0
HFD2_k127_7920572_27 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.000000000000000000000000000005699 129.0
HFD2_k127_7920572_28 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000001737 121.0
HFD2_k127_7920572_29 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000009218 121.0
HFD2_k127_7920572_3 TonB dependent receptor K02014 - - 2.853e-203 667.0
HFD2_k127_7920572_30 FtsZ-dependent cytokinesis - - - 0.00000000000000000003596 101.0
HFD2_k127_7920572_31 Helix-hairpin-helix motif - - - 0.00000000000000001388 87.0
HFD2_k127_7920572_32 protein C3orf30 homolog - - - 0.0002425 44.0
HFD2_k127_7920572_4 Acyclic terpene utilisation family protein AtuA - - - 2.637e-199 642.0
HFD2_k127_7920572_5 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 604.0
HFD2_k127_7920572_6 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 484.0
HFD2_k127_7920572_7 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 425.0
HFD2_k127_7920572_8 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 408.0
HFD2_k127_7920572_9 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 403.0
HFD2_k127_7969965_0 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 449.0
HFD2_k127_7969965_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006501 336.0
HFD2_k127_7969965_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 331.0
HFD2_k127_7969965_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 327.0
HFD2_k127_7969965_4 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005831 293.0
HFD2_k127_7969965_5 Rhomboid family K07059 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005677 262.0
HFD2_k127_7969965_6 negative regulation of phosphate transmembrane transport K02039 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000001305 236.0
HFD2_k127_7969965_7 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000005919 203.0
HFD2_k127_7969965_8 Belongs to the PstS family K02040 - - 0.000000000002792 68.0
HFD2_k127_7993725_0 ABC transporter transmembrane region - - - 4.786e-217 690.0
HFD2_k127_7993725_1 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 523.0
HFD2_k127_7993725_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 432.0
HFD2_k127_7993725_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 384.0
HFD2_k127_7993725_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 394.0
HFD2_k127_7993725_5 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000001186 196.0
HFD2_k127_7993725_6 Peptidase M56 - - - 0.0000000000000000000000000271 124.0
HFD2_k127_7993725_7 Protein of unknown function (DUF2911) - - - 0.00000000000000000000001705 108.0
HFD2_k127_7999649_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1182.0
HFD2_k127_7999649_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.304e-199 629.0
HFD2_k127_7999649_10 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 479.0
HFD2_k127_7999649_11 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 411.0
HFD2_k127_7999649_12 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 375.0
HFD2_k127_7999649_13 PFAM Amidohydrolase 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 370.0
HFD2_k127_7999649_14 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 352.0
HFD2_k127_7999649_15 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 357.0
HFD2_k127_7999649_16 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 337.0
HFD2_k127_7999649_17 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 319.0
HFD2_k127_7999649_18 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 331.0
HFD2_k127_7999649_19 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 314.0
HFD2_k127_7999649_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 627.0
HFD2_k127_7999649_20 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007236 281.0
HFD2_k127_7999649_21 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006261 282.0
HFD2_k127_7999649_22 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001038 273.0
HFD2_k127_7999649_23 Nucleotidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001207 264.0
HFD2_k127_7999649_24 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000007396 244.0
HFD2_k127_7999649_25 Protein kinase domain K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000006483 256.0
HFD2_k127_7999649_26 Glycosyl hydrolase family 3 N terminal domain K05349 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000006538 246.0
HFD2_k127_7999649_27 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000002131 217.0
HFD2_k127_7999649_28 isoleucine patch - - - 0.0000000000000000000000000000000000000000000000000000000001652 209.0
HFD2_k127_7999649_29 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000692 170.0
HFD2_k127_7999649_3 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 623.0
HFD2_k127_7999649_30 Ferric uptake regulator family K03711 - - 0.0000000000000000000000000000000000000009212 156.0
HFD2_k127_7999649_31 Lanthionine synthetase C family protein - - - 0.000000000000000000000000000000000001122 146.0
HFD2_k127_7999649_32 GIY-YIG catalytic domain - - - 0.00000000000000000000000000000202 124.0
HFD2_k127_7999649_33 Forkhead associated domain - - - 0.00000000000000000000000000005068 129.0
HFD2_k127_7999649_34 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000001437 111.0
HFD2_k127_7999649_35 thiolester hydrolase activity K06889 - - 0.000000000000000000003531 102.0
HFD2_k127_7999649_36 peptidyl-tyrosine sulfation - - - 0.0000000000000001849 94.0
HFD2_k127_7999649_37 FHA domain K07315 - 3.1.3.3 0.0000000000901 75.0
HFD2_k127_7999649_38 BrkB protein K07058 - - 0.000000003673 68.0
HFD2_k127_7999649_39 Periplasmic or secreted lipoprotein - - - 0.000000009495 68.0
HFD2_k127_7999649_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 593.0
HFD2_k127_7999649_40 YtxH-like protein - - - 0.0003 49.0
HFD2_k127_7999649_41 - - - - 0.0006113 50.0
HFD2_k127_7999649_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 587.0
HFD2_k127_7999649_6 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 563.0
HFD2_k127_7999649_7 ABC transporter transmembrane region K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 562.0
HFD2_k127_7999649_8 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 548.0
HFD2_k127_7999649_9 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 477.0
HFD2_k127_8047943_0 Heat shock 70 kDa protein K04043 - - 1.144e-318 985.0
HFD2_k127_8047943_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.426e-218 684.0
HFD2_k127_8047943_10 Evidence 4 Homologs of previously reported genes of - - - 0.0000127 51.0
HFD2_k127_8047943_2 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 408.0
HFD2_k127_8047943_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 381.0
HFD2_k127_8047943_4 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009401 289.0
HFD2_k127_8047943_5 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000002881 154.0
HFD2_k127_8047943_6 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000002066 136.0
HFD2_k127_8047943_7 - - - - 0.00000000000000000000009076 106.0
HFD2_k127_8047943_8 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000002177 88.0
HFD2_k127_8047943_9 - - - - 0.00000000000000399 85.0
HFD2_k127_8054552_0 Belongs to the peptidase M16 family K07263 - - 0.0 1065.0
HFD2_k127_8054552_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.628e-266 835.0
HFD2_k127_8054552_10 sequence-specific DNA binding - - - 0.0001474 50.0
HFD2_k127_8054552_2 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 555.0
HFD2_k127_8054552_3 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009433 479.0
HFD2_k127_8054552_4 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001154 271.0
HFD2_k127_8054552_5 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K00950,K01633 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000000000000000005388 261.0
HFD2_k127_8054552_6 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000001891 230.0
HFD2_k127_8054552_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000326 195.0
HFD2_k127_8054552_8 phosphorelay signal transduction system - - - 0.00000000000000000000000000000001137 147.0
HFD2_k127_8054552_9 - - - - 0.00000000000000000000000000226 121.0
HFD2_k127_8056455_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1114.0
HFD2_k127_8056455_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667 - 4.1.99.1 2.27e-217 685.0
HFD2_k127_8056455_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 395.0
HFD2_k127_8056455_11 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 400.0
HFD2_k127_8056455_12 cellular manganese ion homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 380.0
HFD2_k127_8056455_13 Asparaginase K01444 - 3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 362.0
HFD2_k127_8056455_14 VWA domain containing CoxE-like protein K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 369.0
HFD2_k127_8056455_15 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008952 354.0
HFD2_k127_8056455_16 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 341.0
HFD2_k127_8056455_17 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 348.0
HFD2_k127_8056455_18 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009152 356.0
HFD2_k127_8056455_19 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 332.0
HFD2_k127_8056455_2 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 567.0
HFD2_k127_8056455_20 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 326.0
HFD2_k127_8056455_21 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002623 282.0
HFD2_k127_8056455_22 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003197 292.0
HFD2_k127_8056455_23 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001142 281.0
HFD2_k127_8056455_24 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000319 262.0
HFD2_k127_8056455_25 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000004922 261.0
HFD2_k127_8056455_26 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006138 258.0
HFD2_k127_8056455_27 uridine kinase K00876 - 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000001123 247.0
HFD2_k127_8056455_28 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000001164 244.0
HFD2_k127_8056455_29 Peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000005379 201.0
HFD2_k127_8056455_3 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008201 548.0
HFD2_k127_8056455_30 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000001632 192.0
HFD2_k127_8056455_31 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000003066 181.0
HFD2_k127_8056455_32 PFAM HhH-GPD superfamily base excision DNA repair protein K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000005329 176.0
HFD2_k127_8056455_33 Thioredoxin - - - 0.0000000000000000000000000000000000000000004642 164.0
HFD2_k127_8056455_34 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000001003 170.0
HFD2_k127_8056455_35 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000004305 161.0
HFD2_k127_8056455_36 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000003257 156.0
HFD2_k127_8056455_37 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000005207 156.0
HFD2_k127_8056455_38 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000005201 147.0
HFD2_k127_8056455_4 DNA polymerase alpha chain like domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 519.0
HFD2_k127_8056455_40 HEAT repeats - - - 0.000000000000000000000000000000009346 144.0
HFD2_k127_8056455_41 Aminotransferase class-V - - - 0.00000000000000000000000000000003282 140.0
HFD2_k127_8056455_42 domain protein K12516 - - 0.0000000000000000000000000001747 127.0
HFD2_k127_8056455_43 Cysteine-rich CPXCG - - - 0.00000000000000000000000001731 111.0
HFD2_k127_8056455_44 chemotaxis protein K03406 - - 0.0000000000000000000000001303 124.0
HFD2_k127_8056455_45 GAF domain-containing protein K08968 - 1.8.4.14 0.000000000000000000000008487 108.0
HFD2_k127_8056455_47 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000004077 89.0
HFD2_k127_8056455_48 PDZ domain - - - 0.000000000000000004277 95.0
HFD2_k127_8056455_49 Tetratricopeptide repeat - - - 0.00000000000000001507 94.0
HFD2_k127_8056455_5 PFAM DAHP synthetase I KDSA K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 471.0
HFD2_k127_8056455_51 Bacterial regulatory proteins, tetR family - - - 0.00000000009607 71.0
HFD2_k127_8056455_52 Surface antigen - - - 0.000000001573 70.0
HFD2_k127_8056455_53 Protein of unknown function (DUF3187) - - - 0.00000007761 64.0
HFD2_k127_8056455_54 - - - - 0.00000009385 57.0
HFD2_k127_8056455_56 anaphase-promoting complex binding K20276 - - 0.000001127 58.0
HFD2_k127_8056455_57 Pfam:DUF955 - - - 0.000005947 58.0
HFD2_k127_8056455_58 Cro/C1-type HTH DNA-binding domain - - - 0.00001259 51.0
HFD2_k127_8056455_59 TonB-dependent receptor - - - 0.0001097 54.0
HFD2_k127_8056455_6 phosphorelay signal transduction system K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 464.0
HFD2_k127_8056455_60 - - - - 0.0002194 53.0
HFD2_k127_8056455_7 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 451.0
HFD2_k127_8056455_8 M42 glutamyl aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 416.0
HFD2_k127_8056455_9 membrane protein involved in D-alanine export K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 411.0
HFD2_k127_8070212_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000005413 262.0
HFD2_k127_8070212_1 - - - - 0.0000000000000000000000000000000000001095 157.0
HFD2_k127_8070212_2 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000001026 147.0
HFD2_k127_8070212_3 - - - - 0.0000001252 58.0
HFD2_k127_8070212_4 Diguanylate cyclase - - - 0.00009159 48.0
HFD2_k127_8076420_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 448.0
HFD2_k127_8076420_1 Major facilitator Superfamily K08178 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 359.0
HFD2_k127_8076420_2 Domain of unknown function (DUF3471) - - - 0.000000000000000000002984 93.0
HFD2_k127_8099673_0 S53 subtilisin kexin sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 573.0
HFD2_k127_8099673_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 488.0
HFD2_k127_8099673_2 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 332.0
HFD2_k127_8099673_3 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 314.0
HFD2_k127_8099673_4 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000007297 64.0
HFD2_k127_8099673_5 Transcriptional regulator - - - 0.000000007942 59.0
HFD2_k127_8099673_6 Protein of unknown function (DUF2723) - - - 0.00002955 56.0
HFD2_k127_8135491_0 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002056 265.0
HFD2_k127_8135491_1 PFAM Type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000001891 178.0
HFD2_k127_8271027_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 587.0
HFD2_k127_8271027_1 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 346.0
HFD2_k127_8271027_2 Glucose inhibited division protein A K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 307.0
HFD2_k127_8271027_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000001062 191.0
HFD2_k127_8271027_4 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000001137 198.0
HFD2_k127_8271027_5 water channel activity K02440,K06188,K09874 - - 0.000000000000000000000000000000000000895 151.0
HFD2_k127_8271027_6 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000001743 147.0
HFD2_k127_8271027_7 Methyltransferase domain - - - 0.00000000000000000000000000000000001761 150.0
HFD2_k127_8271027_8 Flavin reductase like domain - - - 0.0000000000000000000000000000000002833 150.0
HFD2_k127_8271027_9 - - - - 0.000000000000000000000000000000002063 139.0
HFD2_k127_85719_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000004081 203.0
HFD2_k127_85719_1 impB/mucB/samB family K02346 - 2.7.7.7 0.00000000000000000000000000000000306 137.0
HFD2_k127_85719_2 - - - - 0.0000000000000000000000000005362 120.0
HFD2_k127_85719_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000002887 89.0
HFD2_k127_85719_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00006289 46.0
HFD2_k127_889567_0 Prokaryotic N-terminal methylation motif - - - 0.0001779 53.0
HFD2_k127_889567_1 cell adhesion K02650,K02682 - - 0.0002804 50.0
HFD2_k127_924987_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0 1097.0
HFD2_k127_924987_1 hmm pf02371 K07486 - - 0.000000000000000000003763 94.0
HFD2_k127_924987_2 Belongs to the glycosyl hydrolase 2 family K01190 - 3.2.1.23 0.00000000000004151 75.0
HFD2_k127_938872_0 Protein export membrane protein - - - 0.0 1399.0
HFD2_k127_938872_1 Penicillin amidase - - - 0.0 1079.0
HFD2_k127_938872_10 regulation of response to stimulus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 608.0
HFD2_k127_938872_11 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 558.0
HFD2_k127_938872_12 response to abiotic stimulus K03086,K06867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 535.0
HFD2_k127_938872_13 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 531.0
HFD2_k127_938872_14 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 516.0
HFD2_k127_938872_15 Site-specific recombinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 526.0
HFD2_k127_938872_16 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 490.0
HFD2_k127_938872_17 Thiolase, C-terminal domain K00626,K07508 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 459.0
HFD2_k127_938872_18 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 435.0
HFD2_k127_938872_19 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 426.0
HFD2_k127_938872_2 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 5.038e-279 877.0
HFD2_k127_938872_20 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 422.0
HFD2_k127_938872_21 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 415.0
HFD2_k127_938872_22 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 409.0
HFD2_k127_938872_23 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 380.0
HFD2_k127_938872_24 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 366.0
HFD2_k127_938872_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002616 355.0
HFD2_k127_938872_26 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 349.0
HFD2_k127_938872_27 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 354.0
HFD2_k127_938872_28 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009193 347.0
HFD2_k127_938872_29 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 333.0
HFD2_k127_938872_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 2.769e-269 835.0
HFD2_k127_938872_30 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 336.0
HFD2_k127_938872_31 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 329.0
HFD2_k127_938872_32 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 316.0
HFD2_k127_938872_33 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003295 319.0
HFD2_k127_938872_34 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 303.0
HFD2_k127_938872_35 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 307.0
HFD2_k127_938872_36 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 302.0
HFD2_k127_938872_37 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
HFD2_k127_938872_38 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 301.0
HFD2_k127_938872_39 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005307 279.0
HFD2_k127_938872_4 lysine biosynthetic process via aminoadipic acid - - - 1.916e-253 807.0
HFD2_k127_938872_40 Diphthamide synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006905 279.0
HFD2_k127_938872_41 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007043 272.0
HFD2_k127_938872_42 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000266 266.0
HFD2_k127_938872_43 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002847 262.0
HFD2_k127_938872_44 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009812 264.0
HFD2_k127_938872_45 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000004145 228.0
HFD2_k127_938872_46 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000001126 225.0
HFD2_k127_938872_47 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000002701 218.0
HFD2_k127_938872_48 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000005648 214.0
HFD2_k127_938872_49 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000001055 216.0
HFD2_k127_938872_5 Glycogen debranching enzyme - - - 2.725e-252 806.0
HFD2_k127_938872_50 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000000000007336 198.0
HFD2_k127_938872_51 Biotin-lipoyl like K01993 - - 0.0000000000000000000000000000000000000000000000000000001085 211.0
HFD2_k127_938872_52 - - - - 0.000000000000000000000000000000000000000000000000000001012 197.0
HFD2_k127_938872_53 - - - - 0.000000000000000000000000000000000000000000000000000002512 197.0
HFD2_k127_938872_54 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000001989 201.0
HFD2_k127_938872_55 3'(2'),5'-bisphosphate nucleotidase activity K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000007152 179.0
HFD2_k127_938872_56 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000003744 179.0
HFD2_k127_938872_57 Conserved TM helix - - - 0.000000000000000000000000000000000000000006074 171.0
HFD2_k127_938872_58 Globin - - - 0.00000000000000000000000000000000000000008963 156.0
HFD2_k127_938872_59 - - - - 0.0000000000000000000000000000000000001736 150.0
HFD2_k127_938872_6 WD40-like Beta Propeller Repeat - - - 4.895e-245 807.0
HFD2_k127_938872_60 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000000001096 134.0
HFD2_k127_938872_61 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000001876 134.0
HFD2_k127_938872_62 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000001693 122.0
HFD2_k127_938872_63 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000004715 127.0
HFD2_k127_938872_64 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000004664 129.0
HFD2_k127_938872_65 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000000000000002577 109.0
HFD2_k127_938872_66 - - - - 0.0000000000000000000000004304 116.0
HFD2_k127_938872_67 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000005302 106.0
HFD2_k127_938872_68 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000006347 109.0
HFD2_k127_938872_69 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000007249 105.0
HFD2_k127_938872_7 lysine 2,3-aminomutase K01843 - 5.4.3.2 1.15e-243 758.0
HFD2_k127_938872_70 Calcium/calmodulin dependent protein kinase II association domain - - - 0.0000000000000000007198 93.0
HFD2_k127_938872_71 PFAM regulatory protein TetR - - - 0.0000000000000004237 87.0
HFD2_k127_938872_72 Belongs to the universal stress protein A family - - - 0.00000000000000058 89.0
HFD2_k127_938872_73 Methyl-accepting chemotaxis protein K03406 - - 0.000000000000002547 90.0
HFD2_k127_938872_74 aldo keto reductase - - - 0.000000001411 66.0
HFD2_k127_938872_75 23S rRNA-intervening sequence protein - - - 0.00000001007 62.0
HFD2_k127_938872_76 - - - - 0.00000001241 65.0
HFD2_k127_938872_77 deoxyhypusine monooxygenase activity - - - 0.0000001946 61.0
HFD2_k127_938872_78 Domain of unknown function (DUF4440) - - - 0.000001368 60.0
HFD2_k127_938872_79 diguanylate cyclase - - - 0.000002491 55.0
HFD2_k127_938872_8 TonB dependent receptor - - - 2.601e-224 735.0
HFD2_k127_938872_80 - - - - 0.00000302 56.0
HFD2_k127_938872_81 Aldo/keto reductase family - - - 0.000123 48.0
HFD2_k127_938872_82 lactoylglutathione lyase activity - - - 0.0001499 45.0
HFD2_k127_938872_9 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 6.087e-224 716.0
HFD2_k127_939011_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 359.0
HFD2_k127_988422_0 Sodium:solute symporter family - - - 3.406e-283 880.0
HFD2_k127_988422_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 498.0
HFD2_k127_988422_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002198 244.0
HFD2_k127_988422_3 Roadblock/LC7 domain - - - 0.00000000000000000000000000000000000000000000000000000000002105 209.0
HFD2_k127_988422_4 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000002446 199.0
HFD2_k127_988422_5 - - - - 0.00000000000000000799 91.0
HFD2_k127_988422_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000003214 79.0