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Overview

ID MAG01652
Name HFD2_bin.43
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class JACRHJ01
Order JACRHJ01
Family JACRHJ01
Genus
Species
Assembly information
Completeness (%) 89.95
Contamination (%) 3.13
GC content (%) 62.0
N50 (bp) 14,770
Genome size (bp) 2,413,115

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2246

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_103110_0 Belongs to the transketolase family K00615 - 2.2.1.1 3.993e-275 863.0
HFD2_k127_103110_1 Sugar (and other) transporter K03446 - - 1.268e-206 654.0
HFD2_k127_103110_10 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 373.0
HFD2_k127_103110_11 HlyD membrane-fusion protein of T1SS K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 343.0
HFD2_k127_103110_12 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 330.0
HFD2_k127_103110_13 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 311.0
HFD2_k127_103110_14 ABC transporter K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 308.0
HFD2_k127_103110_15 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 284.0
HFD2_k127_103110_16 SMART metal-dependent phosphohydrolase, HD region K06950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000284 287.0
HFD2_k127_103110_17 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003983 286.0
HFD2_k127_103110_18 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000001733 258.0
HFD2_k127_103110_19 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007265 263.0
HFD2_k127_103110_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 567.0
HFD2_k127_103110_20 Cephalosporin hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003969 258.0
HFD2_k127_103110_21 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001105 267.0
HFD2_k127_103110_22 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000098 250.0
HFD2_k127_103110_23 Histidine kinase K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000002255 259.0
HFD2_k127_103110_24 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006502 252.0
HFD2_k127_103110_25 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000003559 236.0
HFD2_k127_103110_26 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000001744 212.0
HFD2_k127_103110_27 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000001435 212.0
HFD2_k127_103110_28 Transport permease protein K09690 - - 0.0000000000000000000000000000000000000000000000000001221 196.0
HFD2_k127_103110_29 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000001388 197.0
HFD2_k127_103110_3 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 542.0
HFD2_k127_103110_30 Universal stress protein family K07090 - - 0.0000000000000000000000000000000000000000000000000005219 194.0
HFD2_k127_103110_31 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000000000000000000003273 161.0
HFD2_k127_103110_32 - - - - 0.00000000000000000000000000000000000003468 150.0
HFD2_k127_103110_33 PFAM Glycosyltransferase family 9 (heptosyltransferase) K02843,K02849 - - 0.0000000000000000000000000002459 130.0
HFD2_k127_103110_35 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000001733 104.0
HFD2_k127_103110_36 Rubrerythrin - - - 0.0000000000000000001093 90.0
HFD2_k127_103110_37 - - - - 0.00000000000000004404 83.0
HFD2_k127_103110_38 Methyltransferase type 12 - - - 0.000000000003649 78.0
HFD2_k127_103110_39 Endonuclease/Exonuclease/phosphatase family - - - 0.00000004355 65.0
HFD2_k127_103110_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 502.0
HFD2_k127_103110_40 - - - - 0.00002869 48.0
HFD2_k127_103110_5 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 507.0
HFD2_k127_103110_6 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 482.0
HFD2_k127_103110_7 Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006514 468.0
HFD2_k127_103110_8 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 441.0
HFD2_k127_103110_9 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 387.0
HFD2_k127_103622_0 PFAM formate-tetrahydrofolate ligase FTHFS K01938 - 6.3.4.3 1.266e-248 779.0
HFD2_k127_103622_1 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 3.029e-243 768.0
HFD2_k127_103622_10 Permeases of the drug metabolite transporter (DMT) K03298 - - 0.000000000003744 74.0
HFD2_k127_103622_11 Drug metabolite transporter (DMT) superfamily - - - 0.00000000005126 66.0
HFD2_k127_103622_12 denitrification pathway - - - 0.000000002635 70.0
HFD2_k127_103622_13 ThiS family - - - 0.00000002806 58.0
HFD2_k127_103622_2 Ammonium Transporter Family K03320 - - 5.572e-197 622.0
HFD2_k127_103622_3 CO-methylating acetyl-CoA synthase activity K00193,K14138 - 2.3.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 467.0
HFD2_k127_103622_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000008242 222.0
HFD2_k127_103622_5 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000001535 196.0
HFD2_k127_103622_6 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000002454 177.0
HFD2_k127_103622_7 response regulator - - - 0.000000000000000000000001718 112.0
HFD2_k127_103622_8 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.00000000000000002236 89.0
HFD2_k127_103622_9 Chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble K03413 - - 0.00000000000000006376 89.0
HFD2_k127_1050365_0 TIGRFAM Ammonium transporter K03320 - - 1.733e-248 779.0
HFD2_k127_1050365_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 310.0
HFD2_k127_1050365_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000009005 227.0
HFD2_k127_1050365_3 Peptidase family U32 - - - 0.000000000000000000000000000000000000000000000005123 180.0
HFD2_k127_1050365_4 Belongs to the P(II) protein family K04751 - - 0.0000000000006459 68.0
HFD2_k127_1096189_0 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 343.0
HFD2_k127_1096189_1 ABC-type transport system involved in resistance to organic solvents permease component K02066 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 320.0
HFD2_k127_1096189_10 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000001431 247.0
HFD2_k127_1096189_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000000000000000000002159 213.0
HFD2_k127_1096189_12 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000006406 220.0
HFD2_k127_1096189_13 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000006041 187.0
HFD2_k127_1096189_14 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000000000002116 164.0
HFD2_k127_1096189_15 Protein of unknown function (DUF3047) - - - 0.000000000000000000000000000000000000007373 153.0
HFD2_k127_1096189_16 Pfam Response regulator receiver K07658 - - 0.0000000000000000000000000000007873 126.0
HFD2_k127_1096189_17 PFAM UspA domain protein - - - 0.000000002107 64.0
HFD2_k127_1096189_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 308.0
HFD2_k127_1096189_3 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 323.0
HFD2_k127_1096189_4 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 294.0
HFD2_k127_1096189_5 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 304.0
HFD2_k127_1096189_6 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002708 281.0
HFD2_k127_1096189_7 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
HFD2_k127_1096189_8 Permease YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002301 283.0
HFD2_k127_1096189_9 response regulator, receiver K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000001931 264.0
HFD2_k127_1131493_0 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009614 422.0
HFD2_k127_1131493_1 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 368.0
HFD2_k127_1131493_2 - - - - 0.000000008204 57.0
HFD2_k127_1131493_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00004407 55.0
HFD2_k127_1152271_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 4.708e-299 950.0
HFD2_k127_1152271_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001515 270.0
HFD2_k127_1152271_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000001503 214.0
HFD2_k127_1152271_3 Capsule biosynthesis GfcC - - - 0.0000000000000000000000000001616 122.0
HFD2_k127_1154234_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 9.673e-197 631.0
HFD2_k127_1154234_1 Endoribonuclease that initiates mRNA decay K18682 - - 3.049e-194 618.0
HFD2_k127_1154234_10 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.00000000000000000000000000000000005499 136.0
HFD2_k127_1154234_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000004247 128.0
HFD2_k127_1154234_12 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000001939 115.0
HFD2_k127_1154234_14 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000001965 85.0
HFD2_k127_1154234_15 PFAM UvrB UvrC protein - - - 0.00000005065 68.0
HFD2_k127_1154234_16 - - - - 0.00002591 50.0
HFD2_k127_1154234_2 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 543.0
HFD2_k127_1154234_3 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 505.0
HFD2_k127_1154234_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 391.0
HFD2_k127_1154234_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 383.0
HFD2_k127_1154234_6 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 315.0
HFD2_k127_1154234_7 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000155 271.0
HFD2_k127_1154234_8 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000000000000000000000000000000000000000000000000004875 229.0
HFD2_k127_1154234_9 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000002114 163.0
HFD2_k127_1162789_0 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009791 362.0
HFD2_k127_1162789_1 regulator, PATAN and FRGAF domain-containing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007009 260.0
HFD2_k127_1162789_2 Diadenylate cyclase - - - 0.0000000009942 70.0
HFD2_k127_1162789_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000551 49.0
HFD2_k127_1163587_0 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000004226 244.0
HFD2_k127_1163587_1 SMART Tetratricopeptide domain protein - - - 0.000000000000000000000000000000000000000000349 172.0
HFD2_k127_1163587_2 ATP hydrolysis coupled proton transport K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000002516 104.0
HFD2_k127_1187008_0 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 510.0
HFD2_k127_1187008_1 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 411.0
HFD2_k127_1187008_2 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000031 143.0
HFD2_k127_1187008_3 Domain of unknown function (DUF4388) - - - 0.0000000000000000003897 96.0
HFD2_k127_1215838_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 8.698e-301 936.0
HFD2_k127_1215838_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 488.0
HFD2_k127_1215838_10 Predicted membrane protein (DUF2232) - - - 0.00000000004516 73.0
HFD2_k127_1215838_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 413.0
HFD2_k127_1215838_3 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000003933 175.0
HFD2_k127_1215838_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000001785 174.0
HFD2_k127_1215838_5 Ribosomal L25p family K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000004391 140.0
HFD2_k127_1215838_6 Could be involved in septation K06412 - - 0.0000000000000000000000000000002093 127.0
HFD2_k127_1215838_7 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000004812 121.0
HFD2_k127_1215838_8 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000002353 109.0
HFD2_k127_1215838_9 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000001623 99.0
HFD2_k127_124535_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 608.0
HFD2_k127_124535_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 599.0
HFD2_k127_124535_10 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003733 229.0
HFD2_k127_124535_11 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000003977 224.0
HFD2_k127_124535_12 Universal stress protein family K07090 - - 0.00000000000000000000000000000000000000000000000000000001829 214.0
HFD2_k127_124535_13 - - - - 0.000000000000000000000000000000000003105 151.0
HFD2_k127_124535_14 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000000000000000007662 130.0
HFD2_k127_124535_15 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000001123 87.0
HFD2_k127_124535_16 Putative zinc- or iron-chelating domain - - - 0.000000000001839 75.0
HFD2_k127_124535_17 Cell division protein FtsQ K03589 - - 0.00000000203 68.0
HFD2_k127_124535_18 dTDP-4-dehydrorhamnose 3,5-epimerase activity - - - 0.00000001204 62.0
HFD2_k127_124535_2 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 541.0
HFD2_k127_124535_3 cog cog1373 K07133 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 426.0
HFD2_k127_124535_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 417.0
HFD2_k127_124535_5 response to heat K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009751 411.0
HFD2_k127_124535_6 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 360.0
HFD2_k127_124535_7 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 342.0
HFD2_k127_124535_8 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 316.0
HFD2_k127_124535_9 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006331 282.0
HFD2_k127_126628_0 Cytochrome b/b6/petB K00412,K03888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008406 430.0
HFD2_k127_126628_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 389.0
HFD2_k127_126628_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 385.0
HFD2_k127_126628_3 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000000000000000000000002493 166.0
HFD2_k127_126628_4 ATP-grasp domain K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.000000000000000000000000003378 113.0
HFD2_k127_126628_5 - - - - 0.0000000003413 61.0
HFD2_k127_126628_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000257 61.0
HFD2_k127_1289804_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 1.039e-199 636.0
HFD2_k127_1289804_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 556.0
HFD2_k127_1289804_10 coenzyme binding K07071 - - 0.0000000000000000000000007159 116.0
HFD2_k127_1289804_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 381.0
HFD2_k127_1289804_3 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 341.0
HFD2_k127_1289804_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 322.0
HFD2_k127_1289804_5 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002903 265.0
HFD2_k127_1289804_6 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000002428 216.0
HFD2_k127_1289804_7 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000000000000000004519 185.0
HFD2_k127_1289804_8 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.0000000000000000000000000000000000000009751 155.0
HFD2_k127_1289804_9 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000008017 115.0
HFD2_k127_1308466_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 4.395e-242 763.0
HFD2_k127_1308466_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 556.0
HFD2_k127_1308466_10 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.0000000000000006346 79.0
HFD2_k127_1308466_11 Tetratricopeptide repeat - - - 0.0001281 50.0
HFD2_k127_1308466_2 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 476.0
HFD2_k127_1308466_3 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 358.0
HFD2_k127_1308466_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 325.0
HFD2_k127_1308466_5 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000002155 214.0
HFD2_k127_1308466_6 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000005012 205.0
HFD2_k127_1308466_7 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000993 189.0
HFD2_k127_1308466_8 Domain of unknown function (DUF296) - - - 0.00000000000000000000000000000000000004963 147.0
HFD2_k127_1308466_9 energy transducer activity K03832 - - 0.000000000000000000000000005005 123.0
HFD2_k127_1408907_0 Methylenetetrahydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 365.0
HFD2_k127_1408907_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 312.0
HFD2_k127_1408907_2 CO dehydrogenase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006136 292.0
HFD2_k127_1408907_3 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000001628 245.0
HFD2_k127_1408907_4 electron transfer activity K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000000009467 234.0
HFD2_k127_1408907_5 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000002016 167.0
HFD2_k127_1414998_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 3.04e-215 683.0
HFD2_k127_1414998_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 411.0
HFD2_k127_1414998_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 396.0
HFD2_k127_1414998_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K22024 - 1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 332.0
HFD2_k127_1414998_4 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000006334 246.0
HFD2_k127_1414998_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000001106 243.0
HFD2_k127_1414998_6 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000000000000000000000000000009551 154.0
HFD2_k127_1414998_7 RNA-binding S4 domain protein - - - 0.0000000000000000006149 91.0
HFD2_k127_1414998_8 TfoX N-terminal domain - - - 0.0000000009924 64.0
HFD2_k127_1420157_0 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 357.0
HFD2_k127_1420157_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 292.0
HFD2_k127_1420157_2 PFAM iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000000000000000121 217.0
HFD2_k127_1420157_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000002544 208.0
HFD2_k127_1420157_4 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000005922 185.0
HFD2_k127_1420157_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000003255 166.0
HFD2_k127_1420157_6 - - - - 0.000000000003163 75.0
HFD2_k127_1420157_7 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000006072 68.0
HFD2_k127_1477667_0 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 602.0
HFD2_k127_1477667_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K00058,K01754,K04767 - 1.1.1.399,1.1.1.95,4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 420.0
HFD2_k127_1477667_2 Cation efflux family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 303.0
HFD2_k127_1481020_0 4Fe-4S dicluster domain - - - 7.625e-215 674.0
HFD2_k127_1481020_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000458 199.0
HFD2_k127_1481020_2 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.000000000000000000000000000000000002553 141.0
HFD2_k127_1481020_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000005657 81.0
HFD2_k127_1485084_0 PFAM Glycoside hydrolase, family 10 K01181 - 3.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 360.0
HFD2_k127_1485084_1 Glycosyltransferase, group 1 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007461 342.0
HFD2_k127_1485084_2 Glycosyl transferase WecB/TagA/CpsF family K05946 - 2.4.1.187 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000031 278.0
HFD2_k127_1485084_3 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000005444 145.0
HFD2_k127_1556186_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 1.618e-204 646.0
HFD2_k127_1556186_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 1.399e-201 637.0
HFD2_k127_1556186_10 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000001736 175.0
HFD2_k127_1556186_11 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000000001109 158.0
HFD2_k127_1556186_12 Putative cyclase K07130 - 3.5.1.9 0.0000000000000000000000000000000000000001167 166.0
HFD2_k127_1556186_13 Domain in cystathionine beta-synthase and other proteins. K02000,K15986 - 3.6.1.1,3.6.3.32 0.00000000000000000000000000000000002103 139.0
HFD2_k127_1556186_14 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000003342 127.0
HFD2_k127_1556186_15 PFAM Uncharacterised protein family UPF0150 - - - 0.00007138 47.0
HFD2_k127_1556186_2 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 492.0
HFD2_k127_1556186_3 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 364.0
HFD2_k127_1556186_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 294.0
HFD2_k127_1556186_5 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006838 278.0
HFD2_k127_1556186_6 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001576 246.0
HFD2_k127_1556186_7 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000003744 243.0
HFD2_k127_1556186_8 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000007247 228.0
HFD2_k127_1556186_9 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000005979 199.0
HFD2_k127_156181_0 Belongs to the CarB family K01955 - 6.3.5.5 4.369e-230 721.0
HFD2_k127_156181_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 451.0
HFD2_k127_156181_10 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000000000000001594 204.0
HFD2_k127_156181_11 O-methyltransferase activity K05303 - - 0.00000000000000000000000000000000000000000000003018 181.0
HFD2_k127_156181_12 5'-nucleotidase - - - 0.000000000000000000000000000000000000000000003408 181.0
HFD2_k127_156181_13 PFAM response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000000000000000000002075 153.0
HFD2_k127_156181_14 Dodecin K09165 - - 0.00000000000000001105 84.0
HFD2_k127_156181_2 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 418.0
HFD2_k127_156181_3 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 419.0
HFD2_k127_156181_4 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 402.0
HFD2_k127_156181_5 Thiamine biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 325.0
HFD2_k127_156181_6 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 313.0
HFD2_k127_156181_7 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000000002205 245.0
HFD2_k127_156181_8 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.00000000000000000000000000000000000000000000000000000000000000000001262 248.0
HFD2_k127_156181_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000629 197.0
HFD2_k127_1695423_0 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 3.645e-195 631.0
HFD2_k127_1695423_1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 472.0
HFD2_k127_1695423_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009604 274.0
HFD2_k127_1695423_3 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.0000000000000000000000000000000000000000000000000005849 196.0
HFD2_k127_1695423_4 PFAM Curli production assembly transport component CsgG - - - 0.0000000000000000000000000001836 133.0
HFD2_k127_1695423_5 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.00000000000000000000000001224 114.0
HFD2_k127_1695423_6 SMART PDZ DHR GLGF domain protein K11749 - - 0.0000000000000007201 79.0
HFD2_k127_1695423_7 - - - - 0.000001945 61.0
HFD2_k127_1698917_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 412.0
HFD2_k127_1698917_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000009483 161.0
HFD2_k127_1698917_2 Universal stress protein K06149 - - 0.0000000000000000000000000002045 119.0
HFD2_k127_1734852_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 561.0
HFD2_k127_1734852_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 320.0
HFD2_k127_1734852_2 ResB-like family - - - 0.000000000000000000000000000000000000000000000005048 188.0
HFD2_k127_1734852_4 alginic acid biosynthetic process - - - 0.00000000000000000000000000005717 124.0
HFD2_k127_1734852_5 HEAT repeat - - - 0.0000000000001707 76.0
HFD2_k127_1884523_0 histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005852 287.0
HFD2_k127_1884523_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008884 242.0
HFD2_k127_1884523_2 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000001968 189.0
HFD2_k127_1884523_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000004548 179.0
HFD2_k127_1884523_4 RecF/RecN/SMC N terminal domain K03631 - - 0.00000000000000000000000000000211 133.0
HFD2_k127_1884523_5 EamA-like transporter family - - - 0.000000000000000000000000000003311 131.0
HFD2_k127_1884523_6 PFAM PEGA domain - - - 0.000000000002269 80.0
HFD2_k127_1884523_7 KR domain - - - 0.00000002929 58.0
HFD2_k127_1898170_0 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 593.0
HFD2_k127_1898170_1 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008341 563.0
HFD2_k127_1898170_10 Protein of unknown function (DUF1009) K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004331 254.0
HFD2_k127_1898170_11 TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000008535 189.0
HFD2_k127_1898170_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000003038 179.0
HFD2_k127_1898170_13 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000001451 175.0
HFD2_k127_1898170_14 Flavin containing amine oxidoreductase K09835 - 5.2.1.13 0.000000000000000000000001534 118.0
HFD2_k127_1898170_15 Domain of unknown function (DUF4410) - - - 0.000000000000000009698 90.0
HFD2_k127_1898170_16 PFAM Outer membrane K06142 - - 0.0000000000008992 76.0
HFD2_k127_1898170_2 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 440.0
HFD2_k127_1898170_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 383.0
HFD2_k127_1898170_4 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 339.0
HFD2_k127_1898170_5 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 332.0
HFD2_k127_1898170_6 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 324.0
HFD2_k127_1898170_7 B12 binding domain K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 323.0
HFD2_k127_1898170_8 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 302.0
HFD2_k127_1898170_9 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000001298 259.0
HFD2_k127_1926417_0 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 559.0
HFD2_k127_1926417_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 534.0
HFD2_k127_1926417_10 ATP synthase K02115 - - 0.0000000000000000005128 97.0
HFD2_k127_1926417_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000002248 78.0
HFD2_k127_1926417_12 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000114 47.0
HFD2_k127_1926417_13 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0001648 50.0
HFD2_k127_1926417_14 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0003797 52.0
HFD2_k127_1926417_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009787 502.0
HFD2_k127_1926417_3 response regulator K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 313.0
HFD2_k127_1926417_4 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000002267 204.0
HFD2_k127_1926417_5 - - - - 0.0000000000000000000000000000000000000000000000000001121 190.0
HFD2_k127_1926417_6 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000001164 167.0
HFD2_k127_1926417_7 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000001941 140.0
HFD2_k127_1926417_8 PFAM Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000003699 122.0
HFD2_k127_1926417_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000006194 94.0
HFD2_k127_1940116_0 peptidase U32 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 601.0
HFD2_k127_1940116_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007927 460.0
HFD2_k127_1940116_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001013 259.0
HFD2_k127_1940116_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000009811 245.0
HFD2_k127_1940116_4 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000372 216.0
HFD2_k127_1940116_5 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000006022 188.0
HFD2_k127_1940116_6 negative regulation of translational initiation K05554,K15885 - - 0.00000000000000000000000000000000000000018 157.0
HFD2_k127_1940116_7 Response regulator receiver K02482 - 2.7.13.3 0.00000000000000000003365 95.0
HFD2_k127_1984221_0 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 310.0
HFD2_k127_1984221_1 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000001533 226.0
HFD2_k127_1984221_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000002376 134.0
HFD2_k127_1985194_0 mismatched DNA binding K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.712e-266 846.0
HFD2_k127_1985194_1 PFAM Nickel-dependent hydrogenase, large subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 490.0
HFD2_k127_1985194_10 PFAM Cyclic nucleotide-binding domain - - - 0.000000000004174 72.0
HFD2_k127_1985194_11 Pfam:N_methyl_2 - - - 0.000000000007218 80.0
HFD2_k127_1985194_12 type IV pilus modification protein PilV K02458,K02671 - - 0.00000000007153 72.0
HFD2_k127_1985194_13 Prokaryotic N-terminal methylation motif K08084 - - 0.0000000001785 68.0
HFD2_k127_1985194_14 Glucose / Sorbosone dehydrogenase - - - 0.00007981 57.0
HFD2_k127_1985194_15 cellulase activity - - - 0.0001051 57.0
HFD2_k127_1985194_16 Pilus assembly protein PilX K02673 - - 0.0001312 54.0
HFD2_k127_1985194_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 313.0
HFD2_k127_1985194_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002348 280.0
HFD2_k127_1985194_4 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001377 276.0
HFD2_k127_1985194_5 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000008386 235.0
HFD2_k127_1985194_6 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000005673 229.0
HFD2_k127_1985194_7 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000000001674 210.0
HFD2_k127_1985194_8 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000001799 165.0
HFD2_k127_1985194_9 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.000000000000000000000000000000000000001568 157.0
HFD2_k127_1988458_0 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007707 410.0
HFD2_k127_1988458_1 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 364.0
HFD2_k127_1988458_2 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001496 273.0
HFD2_k127_1988458_3 PFAM OsmC family protein K04063 - - 0.00000000000000000000000000000000000000000000000000000954 192.0
HFD2_k127_1988458_4 Psort location CytoplasmicMembrane, score - - - 0.000000000008487 76.0
HFD2_k127_2012335_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 3.606e-197 625.0
HFD2_k127_2012335_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 587.0
HFD2_k127_2012335_10 fibronectin type III domain protein - - - 0.00000000000000000006046 103.0
HFD2_k127_2012335_13 Fibronectin type 3 domain K01637 - 4.1.3.1 0.00000004932 67.0
HFD2_k127_2012335_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009105 518.0
HFD2_k127_2012335_3 Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 381.0
HFD2_k127_2012335_4 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 358.0
HFD2_k127_2012335_5 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001159 252.0
HFD2_k127_2012335_6 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000003874 185.0
HFD2_k127_2012335_7 eight transmembrane protein EpsH - - - 0.0000000000000000000000000000000000000000000009621 177.0
HFD2_k127_2012335_9 Fibronectin type 3 domain K20276 - - 0.0000000000000000000000000001972 134.0
HFD2_k127_2044164_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 535.0
HFD2_k127_2044164_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 501.0
HFD2_k127_2044164_2 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 320.0
HFD2_k127_2044164_3 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000145 186.0
HFD2_k127_2058975_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 629.0
HFD2_k127_2058975_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 461.0
HFD2_k127_2058975_2 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000001994 232.0
HFD2_k127_2058975_3 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000003503 130.0
HFD2_k127_2058975_4 Ami_2 - - - 0.000000000002594 81.0
HFD2_k127_2086169_0 isochorismatase K06901 - - 2.537e-223 704.0
HFD2_k127_2086169_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 1.086e-197 628.0
HFD2_k127_2086169_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 - 3.1.11.2,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 305.0
HFD2_k127_2086169_11 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 321.0
HFD2_k127_2086169_12 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 310.0
HFD2_k127_2086169_13 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 311.0
HFD2_k127_2086169_14 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002694 286.0
HFD2_k127_2086169_15 PFAM ResB family protein K07399 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008941 287.0
HFD2_k127_2086169_16 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000003126 287.0
HFD2_k127_2086169_17 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002418 256.0
HFD2_k127_2086169_18 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000005301 236.0
HFD2_k127_2086169_19 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000002185 216.0
HFD2_k127_2086169_2 Phosphoglycerate kinase K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 586.0
HFD2_k127_2086169_20 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.0000000000000000000000000000000000000000000000000000001905 201.0
HFD2_k127_2086169_21 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000000000000000000000001254 199.0
HFD2_k127_2086169_22 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000003236 194.0
HFD2_k127_2086169_23 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000004247 192.0
HFD2_k127_2086169_24 Belongs to the SUA5 family K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000005578 167.0
HFD2_k127_2086169_25 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000001338 165.0
HFD2_k127_2086169_26 nucleotidyltransferase activity - - - 0.000000000000000000000000000000000000009841 154.0
HFD2_k127_2086169_27 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000005061 148.0
HFD2_k127_2086169_28 signal transduction histidine kinase K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000007687 158.0
HFD2_k127_2086169_29 TPM domain K06872 - - 0.00000000000000000000000000000000000008023 154.0
HFD2_k127_2086169_3 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 512.0
HFD2_k127_2086169_30 Hep Hag repeat protein - - - 0.000000000000000000000000000000003302 140.0
HFD2_k127_2086169_31 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00000000000000000004295 107.0
HFD2_k127_2086169_32 Tetratricopeptide repeat - - - 0.000000000000000472 89.0
HFD2_k127_2086169_33 PFAM Late competence development protein ComFB K02241 - - 0.00002855 51.0
HFD2_k127_2086169_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 475.0
HFD2_k127_2086169_5 TIGRFAM cytochrome C family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 475.0
HFD2_k127_2086169_6 Two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 433.0
HFD2_k127_2086169_8 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 316.0
HFD2_k127_2086169_9 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 313.0
HFD2_k127_2159848_0 Histidine kinase K07646 - 2.7.13.3 0.0 1071.0
HFD2_k127_2159848_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 8.834e-317 983.0
HFD2_k127_2159848_2 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 411.0
HFD2_k127_2159848_3 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 374.0
HFD2_k127_2159848_4 Two component transcriptional regulator, winged helix family K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 347.0
HFD2_k127_2159848_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000002182 240.0
HFD2_k127_2159848_6 - - - - 0.0000000000000000000000000001853 118.0
HFD2_k127_2159848_7 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.00000000000002294 73.0
HFD2_k127_218240_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1092.0
HFD2_k127_218240_1 metal-dependent hydrolase with the TIM-barrel fold - - - 9.671e-270 842.0
HFD2_k127_218240_10 PFAM Integral membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 372.0
HFD2_k127_218240_11 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008022 357.0
HFD2_k127_218240_12 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 349.0
HFD2_k127_218240_13 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 302.0
HFD2_k127_218240_14 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007892 293.0
HFD2_k127_218240_15 PFAM 4Fe-4S binding domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001499 252.0
HFD2_k127_218240_16 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000009701 254.0
HFD2_k127_218240_17 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000001951 229.0
HFD2_k127_218240_18 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000002088 220.0
HFD2_k127_218240_19 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000003112 177.0
HFD2_k127_218240_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 6.818e-219 702.0
HFD2_k127_218240_20 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000001558 176.0
HFD2_k127_218240_21 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000003139 172.0
HFD2_k127_218240_22 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.000000000000000000000000000000000003242 138.0
HFD2_k127_218240_23 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000000001625 131.0
HFD2_k127_218240_24 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000004862 131.0
HFD2_k127_218240_25 Thioesterase superfamily - - - 0.00000000000000000000000000000005578 129.0
HFD2_k127_218240_27 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000005238 119.0
HFD2_k127_218240_28 Signal transducing histidine kinase, homodimeric domain K02487,K06596 - - 0.0000000000000000000401 99.0
HFD2_k127_218240_29 PFAM FHA domain - - - 0.000000002478 64.0
HFD2_k127_218240_3 PFAM magnesium chelatase ChlI subunit K07391 - - 2.018e-210 664.0
HFD2_k127_218240_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 7.056e-198 629.0
HFD2_k127_218240_5 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 530.0
HFD2_k127_218240_6 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 523.0
HFD2_k127_218240_7 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 430.0
HFD2_k127_218240_8 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008739 384.0
HFD2_k127_218240_9 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 371.0
HFD2_k127_2261772_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.227e-238 745.0
HFD2_k127_2261772_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.189e-235 734.0
HFD2_k127_2261772_10 - - - - 0.0001815 45.0
HFD2_k127_2261772_2 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009686 316.0
HFD2_k127_2261772_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 309.0
HFD2_k127_2261772_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000001246 133.0
HFD2_k127_2261772_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000001703 118.0
HFD2_k127_2261772_6 ATP synthase B/B' CF(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000001063 108.0
HFD2_k127_2261772_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000002886 75.0
HFD2_k127_2261772_8 Belongs to the ompA family K03640 - - 0.0000000000002963 77.0
HFD2_k127_2261772_9 Cytochrome c K01179,K03646,K03832 - 3.2.1.4 0.000000003796 66.0
HFD2_k127_2285016_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 6.664e-280 873.0
HFD2_k127_2285016_1 Domain of unknown function (DUF1957) K16149 - 2.4.1.18 1.698e-218 685.0
HFD2_k127_2285016_10 Domain of unknown function (DUF4912) K09942 - - 0.000000000000000000000000000000000000000000000000000826 197.0
HFD2_k127_2285016_11 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000006621 182.0
HFD2_k127_2285016_12 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000003151 123.0
HFD2_k127_2285016_13 - - - - 0.00000000000000009095 84.0
HFD2_k127_2285016_14 PFAM YbbR-like protein - - - 0.0000000000001826 79.0
HFD2_k127_2285016_15 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000408 63.0
HFD2_k127_2285016_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008331 610.0
HFD2_k127_2285016_3 Metallo-beta-lactamase superfamily K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 328.0
HFD2_k127_2285016_4 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008365 313.0
HFD2_k127_2285016_5 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 308.0
HFD2_k127_2285016_6 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 287.0
HFD2_k127_2285016_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000005431 265.0
HFD2_k127_2285016_8 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000002602 237.0
HFD2_k127_2285016_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000005469 204.0
HFD2_k127_2305023_0 Pyridoxal-phosphate dependent enzyme K06001 - 4.2.1.20 5.627e-207 651.0
HFD2_k127_2305023_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 603.0
HFD2_k127_2305023_10 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000000000000000006334 217.0
HFD2_k127_2305023_11 methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000007881 206.0
HFD2_k127_2305023_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 565.0
HFD2_k127_2305023_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007251 460.0
HFD2_k127_2305023_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 377.0
HFD2_k127_2305023_5 Peptidase C26 K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 296.0
HFD2_k127_2305023_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006234 274.0
HFD2_k127_2305023_7 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000003102 260.0
HFD2_k127_2305023_8 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000002137 236.0
HFD2_k127_2305023_9 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000001365 221.0
HFD2_k127_2307332_0 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006864 266.0
HFD2_k127_2307332_1 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002489 257.0
HFD2_k127_2307332_2 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000001877 194.0
HFD2_k127_2307332_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000003472 178.0
HFD2_k127_2307332_4 Belongs to the UPF0434 family K09791 - - 0.00000000000000000002306 93.0
HFD2_k127_2333796_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 3.611e-260 818.0
HFD2_k127_2333796_1 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 313.0
HFD2_k127_2333796_2 PFAM Cytochrome b5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002023 272.0
HFD2_k127_2333796_3 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000004012 203.0
HFD2_k127_2333796_4 - - - - 0.00000000000000000002921 94.0
HFD2_k127_2333796_5 Type III pantothenate kinase K03525 - 2.7.1.33 0.0000000000000000007456 90.0
HFD2_k127_2342368_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 5.562e-207 672.0
HFD2_k127_2342368_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 449.0
HFD2_k127_2342368_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00334,K00335 - 1.6.5.3 0.0000000000000007925 78.0
HFD2_k127_2342368_3 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.00005941 48.0
HFD2_k127_2389676_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 8.708e-279 876.0
HFD2_k127_2389676_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 589.0
HFD2_k127_2389676_10 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000002252 147.0
HFD2_k127_2389676_11 Lysin motif - - - 0.00000000000000000000000000002266 131.0
HFD2_k127_2389676_12 Outer membrane lipoprotein - - - 0.0000000000000000006369 97.0
HFD2_k127_2389676_13 Belongs to the Smg family K03747 - - 0.0006183 48.0
HFD2_k127_2389676_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 525.0
HFD2_k127_2389676_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 389.0
HFD2_k127_2389676_4 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007343 346.0
HFD2_k127_2389676_5 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 295.0
HFD2_k127_2389676_6 TIGRFAM phosphomethylpyrimidine kinase K00941,K14153 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000006243 248.0
HFD2_k127_2389676_7 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000008055 245.0
HFD2_k127_2389676_8 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000001242 239.0
HFD2_k127_2389676_9 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - 0.0000000000000000000000000000000000000000000000000000000000000003223 227.0
HFD2_k127_2391064_0 Carbon starvation protein K06200 - - 7.504e-266 833.0
HFD2_k127_2391064_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.114e-226 724.0
HFD2_k127_2391064_10 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000001064 207.0
HFD2_k127_2391064_11 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000013 186.0
HFD2_k127_2391064_12 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000001384 177.0
HFD2_k127_2391064_13 cytochrome C biogenesis protein ResB K07399 - - 0.00000000000000000000000000785 125.0
HFD2_k127_2391064_14 PFAM UspA domain protein - - - 0.000000000000000000000005913 108.0
HFD2_k127_2391064_15 YtxH-like protein - - - 0.0000000000000000000004893 99.0
HFD2_k127_2391064_16 Tetratricopeptide repeat - - - 0.00000000000000000002891 100.0
HFD2_k127_2391064_17 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000003222 91.0
HFD2_k127_2391064_18 Domain of unknown function (DUF4115) - - - 0.000000000000004217 83.0
HFD2_k127_2391064_19 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000001056 72.0
HFD2_k127_2391064_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 586.0
HFD2_k127_2391064_3 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 439.0
HFD2_k127_2391064_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 419.0
HFD2_k127_2391064_5 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 396.0
HFD2_k127_2391064_6 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 397.0
HFD2_k127_2391064_7 Peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 344.0
HFD2_k127_2391064_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000234 286.0
HFD2_k127_2391064_9 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006687 281.0
HFD2_k127_2392322_0 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 540.0
HFD2_k127_2392322_1 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000205 222.0
HFD2_k127_2392322_2 HD domain - - - 0.000000000000006395 86.0
HFD2_k127_2437616_0 PAS domain K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 536.0
HFD2_k127_2437616_1 Belongs to the acetokinase family K00929 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 351.0
HFD2_k127_2437616_2 Phosphate acetyl/butaryl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000003055 235.0
HFD2_k127_2437616_3 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000021 152.0
HFD2_k127_2437616_4 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.0000000000005499 76.0
HFD2_k127_2453563_0 Catalyzes the synthesis of GMP from XMP K01951,K03790 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 1.247e-210 666.0
HFD2_k127_2453563_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000001539 130.0
HFD2_k127_2487250_0 Polysaccharide biosynthesis/export protein - - - 2.659e-199 649.0
HFD2_k127_2487250_1 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 522.0
HFD2_k127_2487250_2 NAD dependent epimerase/dehydratase family K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 411.0
HFD2_k127_2487250_3 involved in lipopolysaccharide K03606 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001351 301.0
HFD2_k127_2487250_4 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000003834 220.0
HFD2_k127_2487250_5 extracellular polysaccharide biosynthetic process K01153,K05789,K07011,K16554 - 3.1.21.3 0.00000000000000000000000000000000000000000000000000000000000001214 229.0
HFD2_k127_2487250_6 - - - - 0.0000000000000000000000000000000000000000003239 168.0
HFD2_k127_2487250_8 COG2931 RTX toxins and related Ca2 -binding proteins K07004 - - 0.00000005472 65.0
HFD2_k127_2487250_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000003217 59.0
HFD2_k127_2496293_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1073.0
HFD2_k127_2496293_1 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 341.0
HFD2_k127_2496293_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000009113 122.0
HFD2_k127_2496293_3 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000001785 112.0
HFD2_k127_2496293_4 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000105 89.0
HFD2_k127_255734_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 442.0
HFD2_k127_255734_1 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 330.0
HFD2_k127_255734_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000001559 189.0
HFD2_k127_255734_3 Psort location Cytoplasmic, score 8.96 K09949 - - 0.00000000000000000000000000000000000003398 146.0
HFD2_k127_258430_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.758e-238 751.0
HFD2_k127_258430_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 4.491e-231 723.0
HFD2_k127_258430_10 Bacterial regulatory proteins, crp family K01420 - - 0.0000000000000000000000000000000000000000000005039 173.0
HFD2_k127_258430_11 glycoside hydrolase family 57 K16149 - 2.4.1.18 0.000000000000000000000000000000000000000007821 155.0
HFD2_k127_258430_12 protein-glutamate methylesterase activity K03412,K03413,K18876 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 3.1.1.61,3.5.1.44 0.0000000000000000000000002936 113.0
HFD2_k127_258430_13 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000005376 107.0
HFD2_k127_258430_14 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K11686,K13640,K18997 - - 0.00000000000000226 78.0
HFD2_k127_258430_15 Fimbrial assembly protein (PilN) K02663 - - 0.00000000183 67.0
HFD2_k127_258430_16 PFAM Pilus assembly protein PilO K02664 - - 0.0000002674 61.0
HFD2_k127_258430_17 Pilus assembly protein, PilP K02665 - - 0.00002006 56.0
HFD2_k127_258430_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 473.0
HFD2_k127_258430_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 390.0
HFD2_k127_258430_4 pilus assembly protein K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 346.0
HFD2_k127_258430_5 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006672 279.0
HFD2_k127_258430_6 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000636 274.0
HFD2_k127_258430_7 type IV pilus secretin PilQ K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001333 275.0
HFD2_k127_258430_8 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00000000000000000000000000000000000000000000001918 185.0
HFD2_k127_258430_9 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000000000000000000217 175.0
HFD2_k127_2630232_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1085.0
HFD2_k127_2630232_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 5e-284 898.0
HFD2_k127_2630232_10 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 337.0
HFD2_k127_2630232_11 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 329.0
HFD2_k127_2630232_12 Glycosyl hydrolase family 3 K01207,K05349 - 3.2.1.21,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000003748 263.0
HFD2_k127_2630232_13 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000002637 246.0
HFD2_k127_2630232_14 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000004779 211.0
HFD2_k127_2630232_15 transferase activity, transferring glycosyl groups K16703 - - 0.0000000000000000000000000000000000000000000000000000002649 208.0
HFD2_k127_2630232_16 hydrogenase 4 membrane K12140 - - 0.000000000000000000000000000000000000000000000000000002899 197.0
HFD2_k127_2630232_17 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000008655 183.0
HFD2_k127_2630232_18 Histidine kinase - - - 0.0000000000000000000000000000000000008427 151.0
HFD2_k127_2630232_19 12 heme-binding sites - - - 0.000000000000000000000000000005092 127.0
HFD2_k127_2630232_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 634.0
HFD2_k127_2630232_20 Tetratricopeptide repeat - - - 0.000000000000000000003419 99.0
HFD2_k127_2630232_21 methyltransferase activity - - - 0.0000000000000000001258 102.0
HFD2_k127_2630232_22 - - - - 0.0000000000000002156 85.0
HFD2_k127_2630232_23 Hexapeptide repeat of succinyl-transferase K00661 - 2.3.1.79 0.000000000000004159 85.0
HFD2_k127_2630232_24 PFAM Tetratricopeptide repeat - - - 0.000000000004841 74.0
HFD2_k127_2630232_3 PFAM DegT DnrJ EryC1 StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 527.0
HFD2_k127_2630232_4 plastoquinone (Complex I) K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 524.0
HFD2_k127_2630232_5 Proton-conducting membrane transporter K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 528.0
HFD2_k127_2630232_6 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 388.0
HFD2_k127_2630232_7 Ribulose bisphosphate carboxylase large chain, N-terminal domain K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 374.0
HFD2_k127_2630232_8 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007153 355.0
HFD2_k127_2630232_9 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 336.0
HFD2_k127_2632594_0 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00239 - 1.3.5.1,1.3.5.4 9.505e-261 814.0
HFD2_k127_2632594_1 Cache domain - - - 1.587e-250 787.0
HFD2_k127_2632594_2 ATP-grasp domain K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 342.0
HFD2_k127_2632594_3 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006069 323.0
HFD2_k127_2632594_4 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.000000000000000000000000000000000000000000005275 170.0
HFD2_k127_2690848_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.841e-212 668.0
HFD2_k127_2690848_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 482.0
HFD2_k127_2690848_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 369.0
HFD2_k127_2690848_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000003693 207.0
HFD2_k127_2690848_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000002017 106.0
HFD2_k127_2690848_5 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000002309 71.0
HFD2_k127_2690848_6 Ribonuclease P K03536 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.000000000009969 71.0
HFD2_k127_2714540_0 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 486.0
HFD2_k127_2714540_1 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 474.0
HFD2_k127_2714540_2 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 392.0
HFD2_k127_2714540_3 thiolester hydrolase activity K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000009697 177.0
HFD2_k127_2714540_4 - - - - 0.00000000000000002177 85.0
HFD2_k127_2714540_5 - - - - 0.0000000000000297 80.0
HFD2_k127_2714540_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000004903 80.0
HFD2_k127_2714540_7 SMART protein phosphatase 2C domain protein - - - 0.00001856 56.0
HFD2_k127_2859953_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1795.0
HFD2_k127_2859953_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 1.77e-203 644.0
HFD2_k127_2859953_2 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006912 424.0
HFD2_k127_2859953_3 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000001122 125.0
HFD2_k127_2859953_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000733 96.0
HFD2_k127_2897415_0 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001251 266.0
HFD2_k127_2897415_1 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000000000000000001534 245.0
HFD2_k127_2897415_10 cell wall binding repeat 2 - - - 0.00000000000001557 87.0
HFD2_k127_2897415_11 Fibronectin type 3 domain - - - 0.00000000001481 77.0
HFD2_k127_2897415_12 denitrification pathway K03620 - - 0.00000002794 67.0
HFD2_k127_2897415_2 PFAM NUDIX hydrolase - - - 0.00000000000000000000000000000000000000000000000000000002003 202.0
HFD2_k127_2897415_3 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000001315 190.0
HFD2_k127_2897415_4 HAD-hyrolase-like K07025 - - 0.0000000000000000000000000000000000000000000000001755 184.0
HFD2_k127_2897415_6 Zinc ion binding K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.00000000000000000000000000000000007271 151.0
HFD2_k127_2897415_7 COG0607 Rhodanese-related sulfurtransferase K03406,K21028 - 2.8.1.11 0.0000000000000000000009856 98.0
HFD2_k127_2897415_8 peptidyl-prolyl isomerase K07533 - 5.2.1.8 0.00000000000000000009152 104.0
HFD2_k127_2897415_9 PFAM NHL repeat containing protein - - - 0.00000000000001557 87.0
HFD2_k127_2923207_0 Aldehyde dehydrogenase family K22187 - - 1.627e-194 619.0
HFD2_k127_2923207_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 571.0
HFD2_k127_2923207_10 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 341.0
HFD2_k127_2923207_11 Major facilitator Superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006285 317.0
HFD2_k127_2923207_12 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003505 295.0
HFD2_k127_2923207_13 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000097 286.0
HFD2_k127_2923207_14 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000001177 273.0
HFD2_k127_2923207_15 Poly A polymerase, head domain K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001294 267.0
HFD2_k127_2923207_16 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000001696 241.0
HFD2_k127_2923207_17 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000002671 220.0
HFD2_k127_2923207_18 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000000000002751 223.0
HFD2_k127_2923207_19 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000001162 183.0
HFD2_k127_2923207_2 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 563.0
HFD2_k127_2923207_20 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000004678 184.0
HFD2_k127_2923207_21 Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.000000000000000000000000000000003115 144.0
HFD2_k127_2923207_22 Predicted membrane protein (DUF2232) - - - 0.000000002413 61.0
HFD2_k127_2923207_23 - - - - 0.0000000476 66.0
HFD2_k127_2923207_24 - - - - 0.00001206 47.0
HFD2_k127_2923207_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 567.0
HFD2_k127_2923207_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 521.0
HFD2_k127_2923207_5 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 506.0
HFD2_k127_2923207_6 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 458.0
HFD2_k127_2923207_7 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 450.0
HFD2_k127_2923207_8 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 381.0
HFD2_k127_2923207_9 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 344.0
HFD2_k127_2930809_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 430.0
HFD2_k127_2930809_1 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 358.0
HFD2_k127_2930809_10 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000003975 221.0
HFD2_k127_2930809_11 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000001233 220.0
HFD2_k127_2930809_12 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000004675 161.0
HFD2_k127_2930809_13 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.00000000000000000000000000000000000000005864 154.0
HFD2_k127_2930809_14 VanZ like family - - - 0.000000000000000000000000000000000000003044 160.0
HFD2_k127_2930809_15 eight transmembrane protein EpsH - - - 0.00000000000000000000000000000000000000465 157.0
HFD2_k127_2930809_16 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000006332 145.0
HFD2_k127_2930809_17 polysaccharide catabolic process K01179,K04771 - 3.2.1.4,3.4.21.107 0.000000000000000000001392 109.0
HFD2_k127_2930809_18 PFAM Glycosyl transferase, group 1 - - - 0.000000000005533 78.0
HFD2_k127_2930809_2 Glycosyl transferase K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 355.0
HFD2_k127_2930809_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 340.0
HFD2_k127_2930809_4 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 329.0
HFD2_k127_2930809_5 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000085 331.0
HFD2_k127_2930809_6 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 308.0
HFD2_k127_2930809_7 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001154 265.0
HFD2_k127_2930809_8 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001893 251.0
HFD2_k127_2937652_0 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 469.0
HFD2_k127_2937652_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 297.0
HFD2_k127_2937652_2 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007053 255.0
HFD2_k127_2937652_3 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002347 249.0
HFD2_k127_2937652_4 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000006639 214.0
HFD2_k127_2937652_5 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000004862 208.0
HFD2_k127_2937652_6 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000003491 199.0
HFD2_k127_2937652_7 methyltransferase - - - 0.0000000000000000000000000000000000000000000002074 173.0
HFD2_k127_2937652_8 Acyltransferase family - - - 0.000000000000000000000000000000001056 143.0
HFD2_k127_2952651_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 475.0
HFD2_k127_2952651_1 Sigma-54 interaction domain K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 443.0
HFD2_k127_2952651_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000001212 202.0
HFD2_k127_2952651_3 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000009827 134.0
HFD2_k127_2952651_4 oxidoreductase activity, acting on CH-OH group of donors - - - 0.00000000000000000000000000001422 123.0
HFD2_k127_2952682_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K07303 - 1.3.99.16 1.474e-297 949.0
HFD2_k127_2952682_1 Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L- methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by K22466 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 549.0
HFD2_k127_2952682_10 Bacterial sugar transferase K13012,K19428 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000006179 180.0
HFD2_k127_2952682_11 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000001635 186.0
HFD2_k127_2952682_12 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000008828 127.0
HFD2_k127_2952682_13 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000005596 103.0
HFD2_k127_2952682_14 DNA-binding transcription factor activity K03655,K03892,K21903 - 3.6.4.12 0.0000000000000002545 83.0
HFD2_k127_2952682_15 DsrE/DsrF/DrsH-like family - - - 0.000000005757 63.0
HFD2_k127_2952682_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 518.0
HFD2_k127_2952682_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 422.0
HFD2_k127_2952682_4 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 373.0
HFD2_k127_2952682_5 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 338.0
HFD2_k127_2952682_6 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 331.0
HFD2_k127_2952682_7 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001746 270.0
HFD2_k127_2952682_8 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004171 253.0
HFD2_k127_2952682_9 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000114 227.0
HFD2_k127_2979898_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 4.409e-289 907.0
HFD2_k127_2979898_1 DNA topoisomerase II activity K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 393.0
HFD2_k127_2988733_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 1.471e-270 841.0
HFD2_k127_2988733_1 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000573 275.0
HFD2_k127_2992885_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 554.0
HFD2_k127_2992885_1 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 340.0
HFD2_k127_2992885_2 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000009599 241.0
HFD2_k127_2992885_3 PFAM YeeE YedE family (DUF395) K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000017 230.0
HFD2_k127_2992885_4 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000001279 199.0
HFD2_k127_2992885_5 PFAM ATP-binding region, ATPase-like histidine kinase, HAMP region histidine kinase A-like PAS fold-4 K02484 - 2.7.13.3 0.0000000000000000000000000000001212 135.0
HFD2_k127_2992885_6 Domain of unknown function (DUF4418) - - - 0.0000000001035 67.0
HFD2_k127_2992885_7 amine dehydrogenase activity - - - 0.000007184 57.0
HFD2_k127_3020949_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1203.0
HFD2_k127_3020949_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 5.98e-208 663.0
HFD2_k127_3020949_10 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 368.0
HFD2_k127_3020949_11 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 374.0
HFD2_k127_3020949_12 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 370.0
HFD2_k127_3020949_13 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 346.0
HFD2_k127_3020949_14 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007308 336.0
HFD2_k127_3020949_15 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001976 271.0
HFD2_k127_3020949_16 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003911 267.0
HFD2_k127_3020949_17 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007625 258.0
HFD2_k127_3020949_18 response to heat K07090 - - 0.000000000000000000000000000000000000000000000000000000006521 200.0
HFD2_k127_3020949_19 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000001261 171.0
HFD2_k127_3020949_2 Sigma-54 interaction domain - - - 1.323e-206 650.0
HFD2_k127_3020949_20 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000001964 163.0
HFD2_k127_3020949_21 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000001766 166.0
HFD2_k127_3020949_22 Recombination protein O C terminal K03584 - - 0.00000000000000000000000006644 116.0
HFD2_k127_3020949_23 - - - - 0.000000000000000001267 89.0
HFD2_k127_3020949_24 Acetoacetate decarboxylase (ADC) - - - 0.000000000008373 74.0
HFD2_k127_3020949_25 Pilus formation protein N terminal region K02280,K20276 - - 0.00001312 55.0
HFD2_k127_3020949_26 - - - - 0.00002507 46.0
HFD2_k127_3020949_3 glycyl-tRNA aminoacylation K01879 - 6.1.1.14 8.876e-206 661.0
HFD2_k127_3020949_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 3.169e-202 640.0
HFD2_k127_3020949_5 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 528.0
HFD2_k127_3020949_6 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 501.0
HFD2_k127_3020949_7 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 463.0
HFD2_k127_3020949_8 Abc transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 456.0
HFD2_k127_3020949_9 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 395.0
HFD2_k127_3059047_0 alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 384.0
HFD2_k127_3059047_1 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 348.0
HFD2_k127_3059047_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 301.0
HFD2_k127_3059047_3 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000006997 163.0
HFD2_k127_3059047_4 SurA N-terminal domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000003297 164.0
HFD2_k127_3059047_5 - - - - 0.0000003712 57.0
HFD2_k127_3079134_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.967e-210 666.0
HFD2_k127_3079134_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 454.0
HFD2_k127_3079134_10 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000121 194.0
HFD2_k127_3079134_11 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000006618 144.0
HFD2_k127_3079134_12 PFAM Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000006837 108.0
HFD2_k127_3079134_13 Hsp20/alpha crystallin family K13993 - - 0.0000000000503 70.0
HFD2_k127_3079134_14 Tetratricopeptide repeat - - - 0.000002361 58.0
HFD2_k127_3079134_2 Iron-only hydrogenase maturation rSAM protein HydG K03150 - 4.1.99.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 441.0
HFD2_k127_3079134_3 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 369.0
HFD2_k127_3079134_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 365.0
HFD2_k127_3079134_5 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008104 314.0
HFD2_k127_3079134_6 PFAM UBA THIF-type NAD FAD binding protein K03148 - 2.7.7.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 312.0
HFD2_k127_3079134_7 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000004007 241.0
HFD2_k127_3079134_8 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000001011 206.0
HFD2_k127_3079134_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000005677 184.0
HFD2_k127_3087574_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.453e-251 784.0
HFD2_k127_3087574_1 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 416.0
HFD2_k127_3087574_10 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006902 267.0
HFD2_k127_3087574_11 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002038 262.0
HFD2_k127_3087574_12 transferase activity, transferring glycosyl groups K02844 - - 0.00000000000000000000000000000000000000000000000000000000003347 220.0
HFD2_k127_3087574_13 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000001347 210.0
HFD2_k127_3087574_14 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000002076 195.0
HFD2_k127_3087574_15 TIGRFAM D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000003873 195.0
HFD2_k127_3087574_16 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000001062 192.0
HFD2_k127_3087574_17 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000001526 181.0
HFD2_k127_3087574_18 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000111 178.0
HFD2_k127_3087574_19 - - - - 0.0000000000000000000000000000000000000000001131 175.0
HFD2_k127_3087574_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 409.0
HFD2_k127_3087574_20 O-acyltransferase activity - - - 0.0000000000000000000000000000000000000000212 161.0
HFD2_k127_3087574_21 Glycosyltransferase - - - 0.000000000000000000000000000000000000005178 162.0
HFD2_k127_3087574_22 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000399 165.0
HFD2_k127_3087574_23 Methyltransferase domain - - - 0.00000000000000000000000000008854 127.0
HFD2_k127_3087574_24 Belongs to the UPF0434 family K09791 - - 0.000000000000000000001026 95.0
HFD2_k127_3087574_3 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 353.0
HFD2_k127_3087574_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 347.0
HFD2_k127_3087574_5 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 324.0
HFD2_k127_3087574_6 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 294.0
HFD2_k127_3087574_7 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004552 274.0
HFD2_k127_3087574_8 PFAM glycosyl transferase, family 9 K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002475 277.0
HFD2_k127_3087574_9 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003172 269.0
HFD2_k127_3090597_0 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008299 453.0
HFD2_k127_3090597_1 RecF/RecN/SMC N terminal domain K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 316.0
HFD2_k127_3090597_2 regulatory protein IclR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 304.0
HFD2_k127_3090597_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008061 299.0
HFD2_k127_3090597_4 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000003611 207.0
HFD2_k127_3090597_6 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00176 - 1.2.7.3 0.0000000000000003571 81.0
HFD2_k127_3101025_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1144.0
HFD2_k127_3101025_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 522.0
HFD2_k127_3101025_10 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 309.0
HFD2_k127_3101025_11 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 296.0
HFD2_k127_3101025_12 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000639 282.0
HFD2_k127_3101025_13 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002061 283.0
HFD2_k127_3101025_14 RecF/RecN/SMC N terminal domain K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004273 253.0
HFD2_k127_3101025_15 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005392 250.0
HFD2_k127_3101025_16 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000006999 225.0
HFD2_k127_3101025_17 Methyltransferase K15256 - - 0.000000000000000000000000000000000000000000000000000000000007648 214.0
HFD2_k127_3101025_18 Polypeptide deformylase K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000005117 192.0
HFD2_k127_3101025_19 SAM-dependent RNA methyltransferase - - - 0.0000000000000000000000000000000000000000000000000013 199.0
HFD2_k127_3101025_2 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 514.0
HFD2_k127_3101025_20 low molecular weight K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000008486 166.0
HFD2_k127_3101025_21 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000003866 147.0
HFD2_k127_3101025_22 4Fe-4S binding domain - - - 0.00000000000000000000000000000000003962 139.0
HFD2_k127_3101025_23 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000008703 135.0
HFD2_k127_3101025_24 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000000000103 122.0
HFD2_k127_3101025_25 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000001144 124.0
HFD2_k127_3101025_26 Transcriptional regulator, MerR family K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000003396 119.0
HFD2_k127_3101025_27 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000005019 118.0
HFD2_k127_3101025_28 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000001258 120.0
HFD2_k127_3101025_29 cell redox homeostasis - - - 0.000000000000000000008682 101.0
HFD2_k127_3101025_3 Large extracellular alpha-helical protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 511.0
HFD2_k127_3101025_30 PFAM Thioredoxin K03671 - - 0.000000000000000000008752 96.0
HFD2_k127_3101025_31 PFAM PASTA domain - - - 0.0000000000000003716 89.0
HFD2_k127_3101025_32 Domain of unknown function (DUF4082) - - - 0.0000000007801 73.0
HFD2_k127_3101025_33 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.0000002555 64.0
HFD2_k127_3101025_4 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 434.0
HFD2_k127_3101025_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 374.0
HFD2_k127_3101025_6 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 361.0
HFD2_k127_3101025_7 Uncharacterized protein family (UPF0051) K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 340.0
HFD2_k127_3101025_8 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 338.0
HFD2_k127_3101025_9 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 303.0
HFD2_k127_31328_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.887e-212 670.0
HFD2_k127_31328_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 385.0
HFD2_k127_31328_2 PFAM Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000006534 132.0
HFD2_k127_3136250_0 Histidine kinase K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 337.0
HFD2_k127_3136250_1 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004004 254.0
HFD2_k127_3136250_2 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000001275 226.0
HFD2_k127_3136250_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000000005611 111.0
HFD2_k127_3136250_4 histidine kinase - - - 0.0000000000000000000000002999 120.0
HFD2_k127_3136250_5 Transcriptional regulator PadR-like family - - - 0.000000000002366 72.0
HFD2_k127_3169890_0 Phosphoenolpyruvate carboxykinase K01610 - 4.1.1.49 5.24e-264 823.0
HFD2_k127_3169890_1 DNA polymerase alpha chain like domain K02347 - - 1.314e-217 689.0
HFD2_k127_3169890_2 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 578.0
HFD2_k127_3169890_3 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 298.0
HFD2_k127_3169890_4 glycosyl transferase family 2 K21349 - 2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000002658 242.0
HFD2_k127_3169890_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000006522 231.0
HFD2_k127_3169890_6 - - - - 0.0000000002363 68.0
HFD2_k127_3175319_0 Amino acid permease - - - 3.792e-264 830.0
HFD2_k127_3175319_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298 - 1.10.3.10,1.9.3.1 1.023e-206 655.0
HFD2_k127_3175319_2 Flavin containing amine oxidoreductase K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 391.0
HFD2_k127_3175319_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 316.0
HFD2_k127_3175319_4 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000004401 206.0
HFD2_k127_3175319_5 nitric oxide reductase K02164 - - 0.0000000000000000000000000000000000000000000000000001218 192.0
HFD2_k127_3175319_6 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000002106 155.0
HFD2_k127_3175319_7 Amino acid permease - - - 0.0000000000000000000000000000000000002834 143.0
HFD2_k127_3175319_8 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000055 122.0
HFD2_k127_3175319_9 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000001893 53.0
HFD2_k127_3240105_0 NAD synthase K01916 - 6.3.1.5 6.722e-218 690.0
HFD2_k127_3240105_1 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 340.0
HFD2_k127_3240105_2 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002333 279.0
HFD2_k127_3240105_3 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000001735 161.0
HFD2_k127_3240105_4 Domain of unknown function (DUF4412) - - - 0.00000000000000000000008737 107.0
HFD2_k127_3245509_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.498e-222 705.0
HFD2_k127_3245509_1 TIGRFAM type IV-A pilus assembly ATPase PilB K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 571.0
HFD2_k127_3245509_10 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000001325 217.0
HFD2_k127_3245509_11 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000004812 186.0
HFD2_k127_3245509_12 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000001028 190.0
HFD2_k127_3245509_13 NifU-like domain - - - 0.00000000000000000000001309 101.0
HFD2_k127_3245509_14 PFAM Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0000000000000000000002201 106.0
HFD2_k127_3245509_15 ATP-binding region, ATPase domain protein - - - 0.00000000000000002681 88.0
HFD2_k127_3245509_16 electron transfer activity K05337 - - 0.000000000000001986 78.0
HFD2_k127_3245509_17 - - - - 0.000000000009157 67.0
HFD2_k127_3245509_2 PFAM Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 449.0
HFD2_k127_3245509_3 Anthranilate synthase component I K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006782 448.0
HFD2_k127_3245509_4 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 391.0
HFD2_k127_3245509_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 293.0
HFD2_k127_3245509_6 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 290.0
HFD2_k127_3245509_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 286.0
HFD2_k127_3245509_8 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000001979 248.0
HFD2_k127_3245509_9 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000009258 241.0
HFD2_k127_3248828_0 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 305.0
HFD2_k127_3248828_1 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007674 309.0
HFD2_k127_3248828_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000006401 243.0
HFD2_k127_3248828_3 sugar-phosphate isomerases, RpiB LacA LacB family K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000001236 194.0
HFD2_k127_3248828_4 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000006365 133.0
HFD2_k127_3248828_5 response regulator receiver K22010 - - 0.0000000000000000000000000005448 120.0
HFD2_k127_3248828_6 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0007844 42.0
HFD2_k127_3298672_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 438.0
HFD2_k127_3298672_1 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000001284 231.0
HFD2_k127_3298672_2 regulatory protein, FmdB family - - - 0.0000000000000000000003014 98.0
HFD2_k127_3326072_0 response to heat K03696 - - 3.356e-308 964.0
HFD2_k127_3326072_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 362.0
HFD2_k127_3326072_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 310.0
HFD2_k127_3326072_3 Biotin/lipoate A/B protein ligase family K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.00000000000000000000000000000000000000000000000000000000000000001462 235.0
HFD2_k127_3326072_4 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.000000000000000000000000000000000000000000000000000001312 200.0
HFD2_k127_3326072_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000001425 109.0
HFD2_k127_3330964_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0 1019.0
HFD2_k127_3330964_1 Conserved hypothetical protein 698 - - - 1.475e-216 681.0
HFD2_k127_3330964_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 507.0
HFD2_k127_3330964_3 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 359.0
HFD2_k127_3330964_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000002389 184.0
HFD2_k127_3330964_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000000000000000000004221 147.0
HFD2_k127_3330964_6 Domain of unknown function DUF302 - - - 0.000000000000000000007688 104.0
HFD2_k127_3330964_7 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000003606 92.0
HFD2_k127_3330964_8 - - - - 0.000000001171 66.0
HFD2_k127_3330964_9 iron hydrogenase, small subunit K00336,K18332 - 1.12.1.3,1.6.5.3 0.0002559 46.0
HFD2_k127_3337838_0 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009125 597.0
HFD2_k127_3384631_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 616.0
HFD2_k127_3384631_1 stage 0 sporulation protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001277 258.0
HFD2_k127_3384631_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000003812 211.0
HFD2_k127_3384631_3 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000005326 184.0
HFD2_k127_3384631_4 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.00000000000000000000000003246 110.0
HFD2_k127_3385141_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.025e-279 869.0
HFD2_k127_3385141_1 Dehydratase family K01687 - 4.2.1.9 2.252e-246 772.0
HFD2_k127_3385141_10 Transposase - - - 0.0000000000002431 74.0
HFD2_k127_3385141_11 Protein of unknown function (DUF465) K09794 - - 0.0000000002508 64.0
HFD2_k127_3385141_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 4.614e-222 698.0
HFD2_k127_3385141_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 509.0
HFD2_k127_3385141_4 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000002716 254.0
HFD2_k127_3385141_5 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000001014 241.0
HFD2_k127_3385141_6 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000006694 233.0
HFD2_k127_3385141_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000001024 214.0
HFD2_k127_3385141_8 Phosphatidylserine decarboxylase K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000004632 216.0
HFD2_k127_3385141_9 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000004696 119.0
HFD2_k127_3433543_0 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 330.0
HFD2_k127_3433543_1 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 293.0
HFD2_k127_3433543_2 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000002569 248.0
HFD2_k127_3433543_3 antisigma factor binding - - - 0.00000000000005929 83.0
HFD2_k127_3433543_4 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000006324 55.0
HFD2_k127_3434722_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1144.0
HFD2_k127_3434722_1 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 7.258e-249 791.0
HFD2_k127_3434722_10 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000002427 220.0
HFD2_k127_3434722_11 PFAM Nitroreductase family - - - 0.0000000000000000000000000000000000000000000001745 175.0
HFD2_k127_3434722_12 - - - - 0.000000000000000000000000000000000003301 144.0
HFD2_k127_3434722_13 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000002059 123.0
HFD2_k127_3434722_14 Cold shock protein domain K03704 - - 0.000000000000000000000000007291 110.0
HFD2_k127_3434722_15 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000001042 104.0
HFD2_k127_3434722_16 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000002735 78.0
HFD2_k127_3434722_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 475.0
HFD2_k127_3434722_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008602 443.0
HFD2_k127_3434722_4 AhpC/TSA family K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 294.0
HFD2_k127_3434722_5 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000024 287.0
HFD2_k127_3434722_6 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003204 255.0
HFD2_k127_3434722_7 PFAM HhH-GPD family protein K07457 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009832 254.0
HFD2_k127_3434722_8 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000000000000000000000000003028 243.0
HFD2_k127_3434722_9 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000002835 229.0
HFD2_k127_3547076_0 Heterodisulfide reductase subunit A and related polyferredoxins K16886 - - 1.933e-280 880.0
HFD2_k127_3547076_1 FAD dependent oxidoreductase K16885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 553.0
HFD2_k127_3547076_2 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009455 443.0
HFD2_k127_3547076_3 Cytochrome c554 and c-prime - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 431.0
HFD2_k127_3547076_4 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 357.0
HFD2_k127_3547076_5 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 321.0
HFD2_k127_3547076_6 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000000000003308 201.0
HFD2_k127_3581215_0 arsenite transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 593.0
HFD2_k127_3581215_1 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 570.0
HFD2_k127_3581215_2 PAS domain K09155 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 471.0
HFD2_k127_3581215_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 330.0
HFD2_k127_3581215_4 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000004377 171.0
HFD2_k127_3581215_5 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000005168 69.0
HFD2_k127_3581215_6 Pectate lyase superfamily protein - - - 0.0000007683 61.0
HFD2_k127_3596345_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 601.0
HFD2_k127_3596345_1 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 546.0
HFD2_k127_3596345_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 346.0
HFD2_k127_3596345_3 Surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005751 273.0
HFD2_k127_3596345_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000006991 209.0
HFD2_k127_3596345_5 PFAM methyltransferase K15460 - 2.1.1.223 0.0000000000000000000000000000000000000000000000000000000004575 210.0
HFD2_k127_3596345_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000002649 99.0
HFD2_k127_3670799_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 532.0
HFD2_k127_3670799_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 335.0
HFD2_k127_3670799_2 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 299.0
HFD2_k127_3670799_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000002521 278.0
HFD2_k127_3670799_4 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000004753 263.0
HFD2_k127_3670799_5 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000002014 132.0
HFD2_k127_3670799_6 Protein conserved in bacteria K09778 - - 0.0000008627 58.0
HFD2_k127_3723688_0 Acyl-CoA synthetase (NDP forming) K09181 - - 6.546e-225 717.0
HFD2_k127_3723688_1 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 604.0
HFD2_k127_3723688_10 Pfam:Arch_ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 299.0
HFD2_k127_3723688_11 DRTGG domain K13788 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 301.0
HFD2_k127_3723688_12 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 294.0
HFD2_k127_3723688_13 response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003183 304.0
HFD2_k127_3723688_14 HEAT repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006155 298.0
HFD2_k127_3723688_15 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001843 259.0
HFD2_k127_3723688_16 PFAM ApbE family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001559 247.0
HFD2_k127_3723688_17 regulator, PATAN and FRGAF domain-containing - - - 0.000000000000000000000000000000000000000000000000000000000000000000001027 251.0
HFD2_k127_3723688_18 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006003 255.0
HFD2_k127_3723688_19 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000003267 237.0
HFD2_k127_3723688_2 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 597.0
HFD2_k127_3723688_20 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000002672 228.0
HFD2_k127_3723688_21 Response regulator receiver domain K03413 - - 0.0000000000000000000000000000000000000000000003911 169.0
HFD2_k127_3723688_22 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000001382 153.0
HFD2_k127_3723688_23 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000000002682 155.0
HFD2_k127_3723688_24 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000006505 149.0
HFD2_k127_3723688_25 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000000000211 147.0
HFD2_k127_3723688_26 - - - - 0.00000000000000000000000003659 126.0
HFD2_k127_3723688_27 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000004737 116.0
HFD2_k127_3723688_28 Protein of unknown function (DUF507) - - - 0.000000000000000174 86.0
HFD2_k127_3723688_29 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000007352 78.0
HFD2_k127_3723688_3 Cysteine synthase A K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 391.0
HFD2_k127_3723688_30 PFAM TPR repeat-containing protein - - - 0.0000000001926 69.0
HFD2_k127_3723688_31 Protein of unknown function (DUF507) K09804 - - 0.000000003114 61.0
HFD2_k127_3723688_4 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 382.0
HFD2_k127_3723688_5 cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 361.0
HFD2_k127_3723688_6 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 356.0
HFD2_k127_3723688_7 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 349.0
HFD2_k127_3723688_8 Transcriptional regulator K11921,K19338 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 328.0
HFD2_k127_3723688_9 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 315.0
HFD2_k127_3724895_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 586.0
HFD2_k127_3724895_1 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 379.0
HFD2_k127_3724895_2 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000000000000000000002599 225.0
HFD2_k127_3724895_3 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000007231 139.0
HFD2_k127_3724895_4 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000000000000001501 79.0
HFD2_k127_3809663_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009102 472.0
HFD2_k127_3809663_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002369 257.0
HFD2_k127_3809663_2 Thioredoxin-like domain K03671 - - 0.00000000000000000000000000000000000000000003981 162.0
HFD2_k127_3809663_3 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - - 0.0000000000000000000000000001039 123.0
HFD2_k127_3867281_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586,K05366 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 537.0
HFD2_k127_3867281_1 glycogen (starch) synthase activity K00703,K00754 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 334.0
HFD2_k127_3867281_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 291.0
HFD2_k127_3867281_3 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000525 275.0
HFD2_k127_3867281_4 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000002353 229.0
HFD2_k127_3867281_5 peptidyl-tyrosine sulfation - - - 0.000000000000000000002268 100.0
HFD2_k127_3890539_0 Capsule biosynthesis GfcC - - - 7.284e-310 970.0
HFD2_k127_3890539_1 Domain of unknown function (DUF1972) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 477.0
HFD2_k127_3890539_10 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000001279 158.0
HFD2_k127_3890539_11 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000002179 163.0
HFD2_k127_3890539_12 Glycosyl transferase family group 2 K21305 - 2.4.1.335 0.0000000000000000000000000000000001885 148.0
HFD2_k127_3890539_13 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000001933 147.0
HFD2_k127_3890539_14 Outer membrane efflux protein - - - 0.00000000000000000000000002344 115.0
HFD2_k127_3890539_15 polysaccharide biosynthetic process - - - 0.00000000001165 78.0
HFD2_k127_3890539_16 O-Antigen ligase - - - 0.00000000006892 74.0
HFD2_k127_3890539_17 Sugar transferase - - - 0.00000000435 64.0
HFD2_k127_3890539_2 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 463.0
HFD2_k127_3890539_3 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 389.0
HFD2_k127_3890539_4 PFAM lipopolysaccharide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008594 332.0
HFD2_k127_3890539_5 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 327.0
HFD2_k127_3890539_6 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 322.0
HFD2_k127_3890539_7 transferase activity, transferring glycosyl groups K12987,K12988 - - 0.00000000000000000000000000000000000000000000000000000003424 208.0
HFD2_k127_3890539_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000004311 170.0
HFD2_k127_3890539_9 PFAM alpha-L-arabinofuranosidase domain protein K01209 - 3.2.1.55 0.0000000000000000000000000000000000000000007465 175.0
HFD2_k127_3975151_0 COGs COG4397 Mu-like prophage major head subunit gpT - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 387.0
HFD2_k127_3975151_1 Protein of unknown function (DUF935) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 353.0
HFD2_k127_3975151_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001518 269.0
HFD2_k127_3975151_3 Terminase RNaseH-like domain - - - 0.000000000000000000000000000000000000000000000000004564 197.0
HFD2_k127_3975151_4 Mu-like prophage I protein - - - 0.0000000000000000000000000000001748 134.0
HFD2_k127_3975151_5 - - - - 0.00000000000000000000000000002334 124.0
HFD2_k127_3975151_6 PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin K17733 - - 0.00000000000000000000000000516 119.0
HFD2_k127_3975151_7 Mu-like prophage protein GP36 - - - 0.000000000000000007392 88.0
HFD2_k127_3975151_8 Pectate lyase superfamily protein - - - 0.00000000000000002086 98.0
HFD2_k127_3975151_9 Phage virion morphogenesis family - - - 0.000001637 59.0
HFD2_k127_4034088_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 415.0
HFD2_k127_4034088_1 cobalt ion transport K02007 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000001565 248.0
HFD2_k127_4034088_2 helix_turn_helix, Lux Regulon K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000001502 230.0
HFD2_k127_4034088_3 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000001067 202.0
HFD2_k127_4034088_4 nickel-responsive regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000002666 184.0
HFD2_k127_4085731_0 Doubled CXXCH motif (Paired_CXXCH_1) - - - 7.83e-269 862.0
HFD2_k127_4085731_1 Peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 551.0
HFD2_k127_4085731_10 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 308.0
HFD2_k127_4085731_11 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000181 273.0
HFD2_k127_4085731_12 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000005419 169.0
HFD2_k127_4085731_13 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000002573 156.0
HFD2_k127_4085731_14 Histidine kinase - - - 0.0000000000000000000000000000000000868 143.0
HFD2_k127_4085731_15 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000003234 61.0
HFD2_k127_4085731_2 6 heme-binding sites - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 541.0
HFD2_k127_4085731_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 560.0
HFD2_k127_4085731_4 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 510.0
HFD2_k127_4085731_5 PPIC-type PPIASE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 487.0
HFD2_k127_4085731_6 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 413.0
HFD2_k127_4085731_7 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 382.0
HFD2_k127_4085731_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 386.0
HFD2_k127_4085731_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 320.0
HFD2_k127_4216154_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 551.0
HFD2_k127_4216154_1 glycosyl hydrolase, BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009174 484.0
HFD2_k127_4216154_10 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000128 96.0
HFD2_k127_4216154_11 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000003105 81.0
HFD2_k127_4216154_12 calcium- and calmodulin-responsive adenylate cyclase activity K01077,K02388,K02396 - 3.1.3.1 0.00000000000009452 86.0
HFD2_k127_4216154_13 Participates in both transcription termination and antitermination K02600 - - 0.000000002803 59.0
HFD2_k127_4216154_14 - - - - 0.000000005747 65.0
HFD2_k127_4216154_2 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 293.0
HFD2_k127_4216154_3 - - - - 0.000000000000000000000000000000000000000000000000000002431 201.0
HFD2_k127_4216154_4 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000001516 175.0
HFD2_k127_4216154_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000003717 171.0
HFD2_k127_4216154_6 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000000008877 168.0
HFD2_k127_4216154_7 MotA TolQ ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000005791 158.0
HFD2_k127_4216154_8 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000004925 139.0
HFD2_k127_4216154_9 - - - - 0.00000000000000000000000002923 109.0
HFD2_k127_4244345_0 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 531.0
HFD2_k127_4244345_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008235 308.0
HFD2_k127_4244345_2 TIGRFAM Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001156 297.0
HFD2_k127_4244345_3 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000004327 218.0
HFD2_k127_4244345_4 acetyltransferase - - - 0.00000000000000000000000000000001295 130.0
HFD2_k127_4244345_5 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000007898 122.0
HFD2_k127_4244345_6 DNA polymerase alpha chain like domain - - - 0.00003945 54.0
HFD2_k127_4372721_0 Type II/IV secretion system protein K02454,K02652 - - 5.012e-218 700.0
HFD2_k127_4372721_1 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006443 589.0
HFD2_k127_4372721_10 Type II secretory pathway, pseudopilin - - - 0.000000000000000000000000000000000001973 144.0
HFD2_k127_4372721_11 Pfam:N_methyl_2 K02456 - - 0.00000000000000000000000000000000001756 146.0
HFD2_k127_4372721_12 Pilus assembly protein K02662 - - 0.0000000000000000000000000001585 127.0
HFD2_k127_4372721_13 TPR repeat Sel1-like repeat Tetratricopeptide TPR_3 Tetratricopeptide TPR_2 - - - 0.000000000000000000000000001953 126.0
HFD2_k127_4372721_14 E-Z type HEAT repeats - - - 0.000000000000000000001967 113.0
HFD2_k127_4372721_15 Domain of unknown function (DUF1858) - - - 0.00000000000000004328 85.0
HFD2_k127_4372721_17 Pilus assembly protein, PilO K02664 - - 0.0000001926 63.0
HFD2_k127_4372721_19 Tetratricopeptide repeat - - - 0.000003254 59.0
HFD2_k127_4372721_2 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 531.0
HFD2_k127_4372721_20 fumarate reductase K00239 - 1.3.5.1,1.3.5.4 0.00009032 55.0
HFD2_k127_4372721_21 PFAM Fimbrial assembly family protein K02461,K02662,K02663,K12289 - - 0.0001439 52.0
HFD2_k127_4372721_3 type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 431.0
HFD2_k127_4372721_4 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 351.0
HFD2_k127_4372721_5 Histidine kinase HAMP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 355.0
HFD2_k127_4372721_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
HFD2_k127_4372721_7 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000003045 225.0
HFD2_k127_4372721_8 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000001275 201.0
HFD2_k127_4372721_9 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000003019 155.0
HFD2_k127_4407090_0 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 5.443e-233 729.0
HFD2_k127_4407090_1 PFAM glutamate synthase alpha subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007043 314.0
HFD2_k127_4407090_2 Glutamine amidotransferases class-II - - - 0.000000000000000006168 83.0
HFD2_k127_4407090_3 Belongs to the GbsR family K22109 - - 0.0002115 50.0
HFD2_k127_441487_0 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 443.0
HFD2_k127_441487_1 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 398.0
HFD2_k127_441487_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 377.0
HFD2_k127_441487_3 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 364.0
HFD2_k127_441487_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 344.0
HFD2_k127_441487_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000003712 213.0
HFD2_k127_441487_6 Peptidyl-prolyl cis-trans K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000001388 188.0
HFD2_k127_441487_7 heat shock protein binding K05516,K05801 - - 0.0000000000000000000000000000000000000005402 166.0
HFD2_k127_441487_8 TPR repeat - - - 0.000000000000003836 88.0
HFD2_k127_441487_9 thiamine biosynthesis protein ThiS K03154 - - 0.0000000000003951 71.0
HFD2_k127_4415863_0 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 426.0
HFD2_k127_4415863_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 349.0
HFD2_k127_4415863_2 4Fe-4S ferredoxin K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002521 249.0
HFD2_k127_4415863_3 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000004647 205.0
HFD2_k127_4415863_4 12 heme-binding sites - - - 0.000000000000000000000000000000000000001051 163.0
HFD2_k127_4415863_5 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000005467 140.0
HFD2_k127_4415863_7 Decaheme c-type cytochrome, DmsE family - - - 0.0000003244 56.0
HFD2_k127_4418332_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.643e-227 720.0
HFD2_k127_4418332_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 480.0
HFD2_k127_4418332_2 SMART PDZ DHR GLGF domain protein K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001799 261.0
HFD2_k127_4418332_3 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000001935 179.0
HFD2_k127_4418332_4 VanZ like family - - - 0.0000000000000000002736 100.0
HFD2_k127_4418332_5 PilZ domain - - - 0.0000000000000000003309 98.0
HFD2_k127_4418332_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000006047 52.0
HFD2_k127_449371_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K10754 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008526 583.0
HFD2_k127_449371_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008005 309.0
HFD2_k127_449371_2 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 299.0
HFD2_k127_449371_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000003102 186.0
HFD2_k127_4561823_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 405.0
HFD2_k127_4561823_1 Methyltransferase domain - - - 0.0000000004976 68.0
HFD2_k127_4572722_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 383.0
HFD2_k127_4572722_1 sulfate assimilation K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000001033 183.0
HFD2_k127_4600757_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 3.75e-298 937.0
HFD2_k127_4600757_1 Aminotransferase class I and II K14261 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 606.0
HFD2_k127_4600757_10 Metal-dependent phosphohydrolase K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 336.0
HFD2_k127_4600757_11 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003434 322.0
HFD2_k127_4600757_12 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000000000000000000000000000000000000000000000213 203.0
HFD2_k127_4600757_13 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000007027 158.0
HFD2_k127_4600757_14 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K07042 - 3.5.4.5 0.0000000000000000000000000001177 121.0
HFD2_k127_4600757_15 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000001121 120.0
HFD2_k127_4600757_16 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000004059 85.0
HFD2_k127_4600757_17 7TM-HD extracellular K07037 - - 0.00000000000000122 87.0
HFD2_k127_4600757_18 TIGRFAM cytochrome C family protein - - - 0.0000000000001741 79.0
HFD2_k127_4600757_19 PilZ domain - - - 0.0000000001154 64.0
HFD2_k127_4600757_2 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 554.0
HFD2_k127_4600757_20 energy transducer activity K03646,K03832 - - 0.000000001313 68.0
HFD2_k127_4600757_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 533.0
HFD2_k127_4600757_4 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 512.0
HFD2_k127_4600757_5 Proposed homoserine kinase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 471.0
HFD2_k127_4600757_6 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 401.0
HFD2_k127_4600757_7 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 383.0
HFD2_k127_4600757_8 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008398 374.0
HFD2_k127_4600757_9 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 360.0
HFD2_k127_4655002_0 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 301.0
HFD2_k127_4655002_1 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005827 277.0
HFD2_k127_4655002_2 domain protein - - - 0.0000000000000000000000000000000000000000000000000001392 197.0
HFD2_k127_4655002_3 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000000008906 189.0
HFD2_k127_4655002_4 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.00000000000000000000000000000000001183 144.0
HFD2_k127_4657268_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 405.0
HFD2_k127_4657268_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 324.0
HFD2_k127_4657268_10 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000004253 157.0
HFD2_k127_4657268_11 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000248 152.0
HFD2_k127_4657268_12 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000931 140.0
HFD2_k127_4657268_13 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000001363 138.0
HFD2_k127_4657268_14 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000001074 117.0
HFD2_k127_4657268_15 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000005009 109.0
HFD2_k127_4657268_16 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000003836 110.0
HFD2_k127_4657268_17 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000006448 89.0
HFD2_k127_4657268_18 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000004877 66.0
HFD2_k127_4657268_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000403 273.0
HFD2_k127_4657268_3 Ribosomal protein L3 K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001633 256.0
HFD2_k127_4657268_4 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000007399 229.0
HFD2_k127_4657268_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001324 224.0
HFD2_k127_4657268_6 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000002316 220.0
HFD2_k127_4657268_7 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002127 199.0
HFD2_k127_4657268_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000002905 184.0
HFD2_k127_4657268_9 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000005104 179.0
HFD2_k127_4764436_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.0 1287.0
HFD2_k127_4764436_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 413.0
HFD2_k127_4764436_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 350.0
HFD2_k127_4764436_3 Thioredoxin-like domain K03671 - - 0.000000000000000000008414 95.0
HFD2_k127_4764436_4 Domain of unknown function (DUF4911) - - - 0.00001745 50.0
HFD2_k127_4823263_0 elongation factor G K02355 - - 5.782e-212 679.0
HFD2_k127_4823263_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 422.0
HFD2_k127_4823263_10 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000173 114.0
HFD2_k127_4823263_11 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.0000000003393 66.0
HFD2_k127_4823263_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 409.0
HFD2_k127_4823263_3 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003941 377.0
HFD2_k127_4823263_4 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 286.0
HFD2_k127_4823263_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002557 280.0
HFD2_k127_4823263_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005605 269.0
HFD2_k127_4823263_7 Cobinamide kinase / cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000007189 169.0
HFD2_k127_4823263_8 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.00000000000000000000000000000000000000006381 157.0
HFD2_k127_4823263_9 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000007629 127.0
HFD2_k127_4842438_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 527.0
HFD2_k127_4842438_1 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 463.0
HFD2_k127_4842438_10 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000313 207.0
HFD2_k127_4842438_11 - - - - 0.000000000000000000000004466 116.0
HFD2_k127_4842438_2 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007466 385.0
HFD2_k127_4842438_3 undecaprenyl-phosphate glucose phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 368.0
HFD2_k127_4842438_4 AAA domain K02450 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 338.0
HFD2_k127_4842438_5 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 330.0
HFD2_k127_4842438_6 Chain length determinant protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003011 276.0
HFD2_k127_4842438_7 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000003432 253.0
HFD2_k127_4842438_8 TIGRFAM FemAB-related protein, PEP-CTERM system-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000008999 241.0
HFD2_k127_4842438_9 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000001595 219.0
HFD2_k127_4853656_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 396.0
HFD2_k127_4853656_1 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009303 262.0
HFD2_k127_4853656_2 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000843 154.0
HFD2_k127_4853656_3 alginic acid biosynthetic process - - - 0.0000000000000000000000000000001448 136.0
HFD2_k127_4853656_4 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.000000000000000000000000003706 118.0
HFD2_k127_4853656_5 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000007063 115.0
HFD2_k127_4853656_6 Tetratricopeptide repeat - - - 0.00001211 54.0
HFD2_k127_5025957_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 3.114e-279 868.0
HFD2_k127_5025957_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 612.0
HFD2_k127_5025957_10 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001272 273.0
HFD2_k127_5025957_11 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001733 268.0
HFD2_k127_5025957_12 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000001201 235.0
HFD2_k127_5025957_13 Belongs to the Fur family K09825 - - 0.000000000000000000000000000000000000000000000001683 176.0
HFD2_k127_5025957_14 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000001446 153.0
HFD2_k127_5025957_15 transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000008897 140.0
HFD2_k127_5025957_16 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000000000000000000000000003278 137.0
HFD2_k127_5025957_17 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.000000000000000000000000000002539 128.0
HFD2_k127_5025957_18 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000005485 115.0
HFD2_k127_5025957_19 Phosphate-starvation-inducible E - - - 0.000000000007541 71.0
HFD2_k127_5025957_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 484.0
HFD2_k127_5025957_20 PFAM amino acid-binding ACT domain protein - - - 0.0000000001624 67.0
HFD2_k127_5025957_21 Predicted RNA-binding protein - - - 0.000000001176 61.0
HFD2_k127_5025957_22 Calcineurin-like phosphoesterase - - - 0.00000004473 61.0
HFD2_k127_5025957_23 Cobalt ABC transporter, permease protein CbiQ K02008 - - 0.0001208 53.0
HFD2_k127_5025957_24 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0002332 50.0
HFD2_k127_5025957_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 447.0
HFD2_k127_5025957_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 430.0
HFD2_k127_5025957_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 417.0
HFD2_k127_5025957_6 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 398.0
HFD2_k127_5025957_7 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 396.0
HFD2_k127_5025957_8 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 287.0
HFD2_k127_5025957_9 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003108 302.0
HFD2_k127_5101346_0 Hydrogenase expression formation protein hypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 441.0
HFD2_k127_5101346_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 413.0
HFD2_k127_5101346_10 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000001147 136.0
HFD2_k127_5101346_11 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.000000000000000001931 93.0
HFD2_k127_5101346_12 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000000000002271 83.0
HFD2_k127_5101346_13 Tetratricopeptide repeat - - - 0.0000009085 61.0
HFD2_k127_5101346_14 MreB/Mbl protein - - - 0.00001698 53.0
HFD2_k127_5101346_15 Lipopolysaccharide-assembly, LptC-related - - - 0.00009794 52.0
HFD2_k127_5101346_2 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 351.0
HFD2_k127_5101346_3 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 332.0
HFD2_k127_5101346_4 DNA polymerase alpha chain like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003544 264.0
HFD2_k127_5101346_5 Ppx/GppA phosphatase family K01524 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000005652 213.0
HFD2_k127_5101346_6 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000004295 185.0
HFD2_k127_5101346_7 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000000000000000000000445 179.0
HFD2_k127_5101346_8 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000376 160.0
HFD2_k127_5101346_9 AIR synthase related protein, C-terminal domain K04655 - - 0.00000000000000000000000000000000008583 141.0
HFD2_k127_5116316_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1030.0
HFD2_k127_5116316_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 591.0
HFD2_k127_5116316_10 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 307.0
HFD2_k127_5116316_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003542 286.0
HFD2_k127_5116316_12 Polysaccharide biosynthesis protein K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000002995 260.0
HFD2_k127_5116316_13 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000004383 246.0
HFD2_k127_5116316_14 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000000000001187 230.0
HFD2_k127_5116316_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000415 235.0
HFD2_k127_5116316_16 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000001565 205.0
HFD2_k127_5116316_17 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000004617 187.0
HFD2_k127_5116316_18 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752,K13818 - 2.7.7.77 0.00000000000000000000000000000000009846 140.0
HFD2_k127_5116316_19 transcriptional regulator K09017 - - 0.000000000000000003284 93.0
HFD2_k127_5116316_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 485.0
HFD2_k127_5116316_20 protein secretion K03116 - - 0.000000000007651 68.0
HFD2_k127_5116316_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 484.0
HFD2_k127_5116316_4 Male sterility protein K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 475.0
HFD2_k127_5116316_5 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009923 469.0
HFD2_k127_5116316_6 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 425.0
HFD2_k127_5116316_7 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 333.0
HFD2_k127_5116316_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 336.0
HFD2_k127_5116316_9 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007156 305.0
HFD2_k127_5119974_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000851 377.0
HFD2_k127_5119974_1 Aminotransferase class I and II K00817 GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 330.0
HFD2_k127_5119974_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 293.0
HFD2_k127_5119974_3 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 296.0
HFD2_k127_5119974_4 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007436 281.0
HFD2_k127_5119974_5 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000000000008634 241.0
HFD2_k127_5119974_6 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000003506 239.0
HFD2_k127_5121430_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 2.827e-256 813.0
HFD2_k127_5121430_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 416.0
HFD2_k127_5121430_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 387.0
HFD2_k127_5121430_3 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 368.0
HFD2_k127_5121430_4 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000003669 229.0
HFD2_k127_5121430_5 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000004201 168.0
HFD2_k127_5121430_6 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000007329 147.0
HFD2_k127_5121430_7 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000003157 93.0
HFD2_k127_5129933_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 320.0
HFD2_k127_5129933_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000002733 157.0
HFD2_k127_5129933_2 Universal stress protein K06149 - - 0.000000000000000000000000001158 117.0
HFD2_k127_5162035_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009529 363.0
HFD2_k127_5162035_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000005065 229.0
HFD2_k127_5162035_2 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000000000000000000000000000000000000000000000000002846 209.0
HFD2_k127_5162035_3 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000001886 173.0
HFD2_k127_5162035_4 HEAT repeat-containing protein - - - 0.00000000000000005099 95.0
HFD2_k127_5162035_5 Vault protein inter-alpha-trypsin domain - - - 0.000007136 58.0
HFD2_k127_5186377_0 glycosyl transferase family 2 K21349 - 2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 389.0
HFD2_k127_5186377_1 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 346.0
HFD2_k127_5186377_2 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003068 279.0
HFD2_k127_5186377_3 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000004011 205.0
HFD2_k127_5186377_5 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000003694 108.0
HFD2_k127_5186377_6 - - - - 0.0000000000000000000006401 101.0
HFD2_k127_5186377_7 PFAM DsrE DsrF-like family - - - 0.000000001619 63.0
HFD2_k127_5199791_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 551.0
HFD2_k127_5199791_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 533.0
HFD2_k127_5199791_10 PFAM Rubredoxin-type Fe(Cys)4 protein K05297 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592 1.18.1.1 0.00000000000000000000000515 102.0
HFD2_k127_5199791_11 response regulator - - - 0.00000000000000000000004061 108.0
HFD2_k127_5199791_12 - - - - 0.0000000000000000004047 97.0
HFD2_k127_5199791_13 3-beta hydroxysteroid dehydrogenase isomerase K22320 - 1.1.1.412 0.00000000006014 73.0
HFD2_k127_5199791_14 Rubrerythrin - - - 0.000001052 57.0
HFD2_k127_5199791_2 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 547.0
HFD2_k127_5199791_3 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006551 500.0
HFD2_k127_5199791_4 PDZ domain (Also known as DHR or GLGF) K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 456.0
HFD2_k127_5199791_5 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 289.0
HFD2_k127_5199791_6 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000000000000000000000000000000000000000002297 248.0
HFD2_k127_5199791_7 coenzyme binding K07071 - - 0.00000000000000000000000000000000000006192 154.0
HFD2_k127_5199791_8 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000001197 144.0
HFD2_k127_5199791_9 metal-dependent phosphohydrolase HD sub domain - - - 0.0000000000000000000000000000000000818 149.0
HFD2_k127_5221129_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 545.0
HFD2_k127_5221129_1 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000002789 155.0
HFD2_k127_5221129_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000001586 150.0
HFD2_k127_5257942_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 512.0
HFD2_k127_5257942_1 Ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 454.0
HFD2_k127_5257942_2 NGG1p interacting factor 3 K22391 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000001004 207.0
HFD2_k127_5257942_3 Ribonuclease H K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000002138 169.0
HFD2_k127_5257942_4 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000005388 106.0
HFD2_k127_5257942_5 thiolester hydrolase activity K06889 - - 0.00000000000000000007421 99.0
HFD2_k127_5257942_6 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.000000000000006419 74.0
HFD2_k127_5269149_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 2.028e-270 857.0
HFD2_k127_5269149_1 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 365.0
HFD2_k127_5269149_2 Dinitrogenase iron-molybdenum cofactor K02596 - - 0.000000000000000000000000000000000000000006728 157.0
HFD2_k127_5269149_3 Nitrogen regulatory protein P-II K02589 - - 0.0000000000000000000000000000000000000002246 155.0
HFD2_k127_5269149_4 PFAM NifQ family protein K15790 - - 0.000000000000000000000000000000000000004874 148.0
HFD2_k127_5269149_5 Nitrogen regulatory protein P-II K02590 - - 0.0000000000000000000000000000001581 134.0
HFD2_k127_5269149_6 TIGRFAM ferredoxin III, nif-specific - - - 0.0000000000000000000000009875 111.0
HFD2_k127_5272989_0 Protein of unknown function (DUF401) K09133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 336.0
HFD2_k127_5272989_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 326.0
HFD2_k127_5272989_2 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.00000000000000000000000000000000000000000000000008187 181.0
HFD2_k127_5272989_3 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.00000000000000000000000000000000000000000000000008483 186.0
HFD2_k127_5272989_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000542 128.0
HFD2_k127_5273090_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008873 328.0
HFD2_k127_5273090_1 MazG family K02428,K02499 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 300.0
HFD2_k127_5273090_2 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005209 275.0
HFD2_k127_5273090_3 PFAM response regulator receiver K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000005919 235.0
HFD2_k127_5273090_4 Sensor histidine kinase, HAMP domain-containing K07644 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001356 204.0
HFD2_k127_5273090_5 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000001208 113.0
HFD2_k127_5273090_6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000004199 79.0
HFD2_k127_5273090_7 - - - - 0.000000005297 62.0
HFD2_k127_5273090_8 - K01992,K19341 - - 0.0002265 52.0
HFD2_k127_5304818_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 539.0
HFD2_k127_5304818_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 512.0
HFD2_k127_5304818_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 448.0
HFD2_k127_5304818_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000005569 260.0
HFD2_k127_5304818_4 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000002584 196.0
HFD2_k127_5357569_0 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 8.852e-243 763.0
HFD2_k127_5357569_1 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000004845 198.0
HFD2_k127_5357569_2 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000614 72.0
HFD2_k127_5357569_3 Lipopolysaccharide-assembly - - - 0.000001474 57.0
HFD2_k127_5361249_0 COGs COG4397 Mu-like prophage major head subunit gpT - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 381.0
HFD2_k127_5361249_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 364.0
HFD2_k127_5361249_10 Phage virion morphogenesis - - - 0.0001887 52.0
HFD2_k127_5361249_2 COGs COG4383 Mu-like prophage protein gp29 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 351.0
HFD2_k127_5361249_3 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 328.0
HFD2_k127_5361249_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002095 271.0
HFD2_k127_5361249_5 COGs COG4388 Mu-like prophage I protein - - - 0.00000000000000000000000000000000000000000000000000000059 203.0
HFD2_k127_5361249_6 Terminase RNaseH-like domain - - - 0.00000000000000000000000000000000000000000000000000167 203.0
HFD2_k127_5361249_7 - - - - 0.0000000000000000000000000003984 121.0
HFD2_k127_5361249_8 Mu-like prophage protein GP36 - - - 0.000000000000005491 79.0
HFD2_k127_5361249_9 Pectate lyase superfamily protein - - - 0.00000000000006817 87.0
HFD2_k127_5391897_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.912e-242 771.0
HFD2_k127_5391897_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008117 383.0
HFD2_k127_5391897_2 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002942 263.0
HFD2_k127_5391897_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000007159 233.0
HFD2_k127_5391897_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000004616 135.0
HFD2_k127_5391897_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000002577 126.0
HFD2_k127_5391897_6 Protein of unknown function (DUF503) K09764 - - 0.000000000000000000004514 97.0
HFD2_k127_5413333_0 Belongs to the EPSP synthase family. MurA subfamily K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 540.0
HFD2_k127_5413333_1 Histidinol dehydrogenase K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 501.0
HFD2_k127_5413333_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 407.0
HFD2_k127_5413333_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 384.0
HFD2_k127_5413333_4 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000003367 225.0
HFD2_k127_5413333_5 GIY-YIG catalytic domain - - - 0.0000000000000000000000003239 107.0
HFD2_k127_5413333_6 nuclear chromosome segregation - - - 0.00000000006525 74.0
HFD2_k127_5420987_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1961.0
HFD2_k127_5420987_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000001463 222.0
HFD2_k127_5420987_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000104 213.0
HFD2_k127_5453083_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 574.0
HFD2_k127_5453083_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 496.0
HFD2_k127_5453083_2 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009946 318.0
HFD2_k127_5453083_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006555 267.0
HFD2_k127_5453083_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000001205 198.0
HFD2_k127_5453083_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000694 190.0
HFD2_k127_5453083_6 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571,K01960 - 4.1.1.3,6.4.1.1 0.0000000000000000000000000000000000000001059 155.0
HFD2_k127_5453083_7 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.0000000000000000003058 101.0
HFD2_k127_5453083_8 Roadblock/LC7 domain K07131 - - 0.000000001801 63.0
HFD2_k127_5480612_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1204.0
HFD2_k127_5480612_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000828 471.0
HFD2_k127_5480612_10 Biotin-protein ligase, N terminal - - - 0.00000000000000000007148 96.0
HFD2_k127_5480612_2 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 439.0
HFD2_k127_5480612_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000001914 266.0
HFD2_k127_5480612_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003361 263.0
HFD2_k127_5480612_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000001822 229.0
HFD2_k127_5480612_6 cyclohydrolase K01746 - 4.3.1.4 0.00000000000000000000000000000000000000000000008973 176.0
HFD2_k127_5480612_7 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000001005 162.0
HFD2_k127_5480612_8 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000000000000007849 146.0
HFD2_k127_5480612_9 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000003343 132.0
HFD2_k127_5493939_0 PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000000000404 223.0
HFD2_k127_5493939_1 - - - - 0.00000000000000000000000000000000000000000000147 183.0
HFD2_k127_5493939_2 translation initiation factor activity K00694 - 2.4.1.12 0.000000000000003189 89.0
HFD2_k127_5506108_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.029e-198 626.0
HFD2_k127_5506108_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 576.0
HFD2_k127_5506108_2 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 525.0
HFD2_k127_5506108_3 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 361.0
HFD2_k127_5506108_4 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.00000000000001338 74.0
HFD2_k127_5506108_5 cell cycle K05589,K12065,K13052 - - 0.00000005765 59.0
HFD2_k127_5531639_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009588 438.0
HFD2_k127_5531639_1 Belongs to the ompA family K03286 - - 0.0000000000000000002864 96.0
HFD2_k127_5532221_0 Seven times multi-haem cytochrome CxxCH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 475.0
HFD2_k127_5532221_1 Sporulation and spore germination - - - 0.0000000000000000000000002474 119.0
HFD2_k127_5532221_2 Ami_3 K01448 - 3.5.1.28 0.000000000000000000001928 106.0
HFD2_k127_5532221_3 cellular component assembly - - - 0.0000000000005561 73.0
HFD2_k127_5618343_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007783 467.0
HFD2_k127_5618343_1 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 389.0
HFD2_k127_5618343_2 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004959 267.0
HFD2_k127_5618343_3 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000841 151.0
HFD2_k127_5721212_0 TIGRFAM formate dehydrogenase, alpha subunit K00336,K05299 - 1.17.1.10,1.6.5.3 9.73e-212 687.0
HFD2_k127_5721212_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 510.0
HFD2_k127_5721212_10 oxidoreductase K00334 - 1.6.5.3 0.00000000000000000000000000000000000000001169 159.0
HFD2_k127_5721212_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000002022 154.0
HFD2_k127_5721212_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000009167 118.0
HFD2_k127_5721212_13 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000003017 132.0
HFD2_k127_5721212_14 ribonuclease BN K07058 - - 0.000000000000001188 87.0
HFD2_k127_5721212_15 - - - - 0.00000000004256 66.0
HFD2_k127_5721212_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 498.0
HFD2_k127_5721212_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 393.0
HFD2_k127_5721212_4 NADH-quinone oxidoreductase K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 311.0
HFD2_k127_5721212_5 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 304.0
HFD2_k127_5721212_6 GTP binding K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000001796 258.0
HFD2_k127_5721212_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000008184 234.0
HFD2_k127_5721212_8 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000001935 222.0
HFD2_k127_5721212_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000003961 177.0
HFD2_k127_5753560_0 GTP-binding protein TypA K06207 - - 9.009e-261 817.0
HFD2_k127_5753560_1 PFAM type II secretion system protein E K02283,K03609 - - 1.278e-199 630.0
HFD2_k127_5753560_10 TIGRFAM Flp pilus assembly protein CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000000000000004056 224.0
HFD2_k127_5753560_11 Ion transport 2 domain protein - - - 0.00000000000000000000000000000002788 135.0
HFD2_k127_5753560_12 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000005328 108.0
HFD2_k127_5753560_13 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000009611 104.0
HFD2_k127_5753560_14 Response receiver sensor diguanylate cyclase, PAS domain-containing - - - 0.000000002091 60.0
HFD2_k127_5753560_16 TadE-like protein - - - 0.000007889 54.0
HFD2_k127_5753560_17 PFAM TadE family protein - - - 0.00001215 56.0
HFD2_k127_5753560_2 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 546.0
HFD2_k127_5753560_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 542.0
HFD2_k127_5753560_4 IMG reference gene - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 395.0
HFD2_k127_5753560_5 Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 306.0
HFD2_k127_5753560_6 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001155 291.0
HFD2_k127_5753560_7 Pilus formation protein N terminal region K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000419 289.0
HFD2_k127_5753560_8 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000004544 246.0
HFD2_k127_5753560_9 Flp pilus assembly protein K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000003425 234.0
HFD2_k127_5767914_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 437.0
HFD2_k127_5767914_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008291 317.0
HFD2_k127_5767914_10 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000005358 98.0
HFD2_k127_5767914_11 Predicted membrane protein (DUF2318) - - - 0.0000000000000000005258 92.0
HFD2_k127_5767914_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005343 267.0
HFD2_k127_5767914_3 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000001312 225.0
HFD2_k127_5767914_4 - - - - 0.0000000000000000000000000000000000000000000000001305 191.0
HFD2_k127_5767914_5 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000009983 176.0
HFD2_k127_5767914_6 Histidine kinase K07651 - 2.7.13.3 0.000000000000000000000000000000000000000157 171.0
HFD2_k127_5767914_7 PFAM response regulator receiver - - - 0.00000000000000000000000000003392 121.0
HFD2_k127_5767914_8 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000001058 102.0
HFD2_k127_5767914_9 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000001115 100.0
HFD2_k127_5775647_0 Chain length determinant protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001002 274.0
HFD2_k127_5775647_1 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000000000000000000000000000000000000003869 223.0
HFD2_k127_5775647_2 Capsular exopolysaccharide family K08252 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000001253 214.0
HFD2_k127_5775647_3 Transcription termination factor nusG - - - 0.0000000000000817 73.0
HFD2_k127_5932901_0 Orn/Lys/Arg decarboxylase, C-terminal domain K01582,K01585 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.1.1.18,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 569.0
HFD2_k127_5932901_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 402.0
HFD2_k127_5932901_2 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000001143 248.0
HFD2_k127_5932901_3 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000000000000000001056 214.0
HFD2_k127_5932901_4 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000000000000000004037 191.0
HFD2_k127_5932901_5 4Fe-4S binding domain - - - 0.0000000000000000000722 90.0
HFD2_k127_5932901_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000001479 88.0
HFD2_k127_5933522_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 4.424e-200 630.0
HFD2_k127_5933522_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 302.0
HFD2_k127_5933522_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001657 290.0
HFD2_k127_5938222_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 476.0
HFD2_k127_5938222_1 peptidase U32 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004056 273.0
HFD2_k127_5938222_2 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000007459 228.0
HFD2_k127_5938222_3 - - - - 0.0000004685 54.0
HFD2_k127_5938222_4 - - - - 0.00009527 48.0
HFD2_k127_5950463_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 589.0
HFD2_k127_5950463_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 569.0
HFD2_k127_5950463_10 Glycerol-3-phosphate acyltransferase - - - 0.000000000000009408 81.0
HFD2_k127_5950463_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 525.0
HFD2_k127_5950463_3 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 497.0
HFD2_k127_5950463_4 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 351.0
HFD2_k127_5950463_5 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009879 280.0
HFD2_k127_5950463_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000002118 222.0
HFD2_k127_5950463_7 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000002771 190.0
HFD2_k127_5950463_8 PFAM transglutaminase domain protein - - - 0.00000000000000000000000001572 121.0
HFD2_k127_5950463_9 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000002779 108.0
HFD2_k127_6146914_0 GTP-binding GTPase Middle Region K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 595.0
HFD2_k127_6146914_1 FAD binding domain K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 589.0
HFD2_k127_6146914_10 Evidence 5 No homology to any previously reported sequences - - - 0.0000008372 56.0
HFD2_k127_6146914_11 Type IV pilus biogenesis stability protein PilW - - - 0.000002884 50.0
HFD2_k127_6146914_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 411.0
HFD2_k127_6146914_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 329.0
HFD2_k127_6146914_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000002428 174.0
HFD2_k127_6146914_5 lyase activity - - - 0.00000000000000000000000000000000000002149 163.0
HFD2_k127_6146914_6 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000000000001416 138.0
HFD2_k127_6146914_7 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000002553 139.0
HFD2_k127_6146914_8 Nitroreductase family - - - 0.0000000000005721 78.0
HFD2_k127_6146914_9 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.00000000188 63.0
HFD2_k127_6189227_0 helicase superfamily c-terminal domain K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 532.0
HFD2_k127_6189227_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006855 382.0
HFD2_k127_6189227_2 electron transport complex, RnfABCDGE type, B subunit K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005286 282.0
HFD2_k127_6192665_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 547.0
HFD2_k127_6192665_1 Ferrous iron transport protein B K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001423 278.0
HFD2_k127_6192665_2 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000004509 271.0
HFD2_k127_6192665_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000003513 248.0
HFD2_k127_6214349_0 Part of a membrane complex involved in electron transport K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 471.0
HFD2_k127_6214349_1 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000002484 261.0
HFD2_k127_6214349_2 glycine hydroxymethyltransferase activity K00600 GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000001267 231.0
HFD2_k127_6214349_3 ATP cone domain K07738 - - 0.000000000000000000000000000000000000000000000000000000002497 203.0
HFD2_k127_6214349_4 Part of a membrane complex involved in electron transport K03614 - - 0.00000234 50.0
HFD2_k127_6242101_0 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 3.762e-291 905.0
HFD2_k127_6242101_1 Alanine dehydrogenase/PNT, C-terminal domain K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 606.0
HFD2_k127_6242101_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 479.0
HFD2_k127_6242101_3 helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 313.0
HFD2_k127_6242101_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000085 284.0
HFD2_k127_6242101_5 6-phosphogluconolactonase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002381 256.0
HFD2_k127_6242101_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000005622 234.0
HFD2_k127_6242101_7 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000009043 227.0
HFD2_k127_6242101_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000001257 163.0
HFD2_k127_6242101_9 - - - - 0.000000000000000000000000000004623 123.0
HFD2_k127_6247615_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1574.0
HFD2_k127_6247615_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000001766 269.0
HFD2_k127_6258661_0 PFAM aminotransferase, class I and II K10206 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0010285,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0033362,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 549.0
HFD2_k127_6258661_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 325.0
HFD2_k127_6258661_10 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000002506 112.0
HFD2_k127_6258661_12 Protein of unknown function (DUF3106) - - - 0.0000001033 61.0
HFD2_k127_6258661_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 318.0
HFD2_k127_6258661_3 fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 306.0
HFD2_k127_6258661_4 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 295.0
HFD2_k127_6258661_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000012 221.0
HFD2_k127_6258661_6 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000003526 210.0
HFD2_k127_6258661_7 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000003203 158.0
HFD2_k127_6258661_8 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000002442 158.0
HFD2_k127_6258661_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000006931 136.0
HFD2_k127_6262151_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 382.0
HFD2_k127_6262151_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 337.0
HFD2_k127_6262151_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000003154 208.0
HFD2_k127_6262151_3 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000004263 134.0
HFD2_k127_6357089_0 DNA segregation ATPase, FtsK SpoIIIE family K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 618.0
HFD2_k127_6357089_1 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 328.0
HFD2_k127_6357089_2 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000002979 111.0
HFD2_k127_6357089_3 Serine threonine protein kinase - - - 0.0003146 50.0
HFD2_k127_6414443_0 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000001229 264.0
HFD2_k127_6414443_1 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.000000000000000000000000000000000005574 146.0
HFD2_k127_6414443_2 Protein of unknown function (DUF1015) - - - 0.00000000000000000004347 92.0
HFD2_k127_6414443_3 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.0000000000673 69.0
HFD2_k127_6421335_0 HELICc2 K03722 - 3.6.4.12 1.543e-242 775.0
HFD2_k127_6421335_1 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 350.0
HFD2_k127_6421335_2 PFAM Transketolase central region K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000001801 152.0
HFD2_k127_6421335_3 Desulfoferrodoxin ferrous iron-binding K05919 - 1.15.1.2 0.00000000000000000000000000000005782 125.0
HFD2_k127_6421335_4 Colicin V production protein K03558 - - 0.000000006744 64.0
HFD2_k127_6487879_0 nitrogenase component I, alpha chain K02586 - 1.18.6.1 2.178e-239 752.0
HFD2_k127_6487879_1 GAF domain K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 522.0
HFD2_k127_6487879_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588,K04037,K11333 - 1.18.6.1,1.3.7.14,1.3.7.15,1.3.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 468.0
HFD2_k127_6487879_3 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008253 316.0
HFD2_k127_6487879_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000003703 122.0
HFD2_k127_6506030_0 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 512.0
HFD2_k127_6506030_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002224 258.0
HFD2_k127_6506030_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000033 216.0
HFD2_k127_6506030_3 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000004685 185.0
HFD2_k127_6506030_4 response regulator receiver K02481 - - 0.00000000000000000000000000000008846 128.0
HFD2_k127_6539351_0 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000003839 200.0
HFD2_k127_6539351_1 - K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000001553 169.0
HFD2_k127_6539351_2 PFAM glycosyl transferase family 9 K02843 - - 0.0000000000000000000000000000002687 139.0
HFD2_k127_6554931_0 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 1.827e-202 645.0
HFD2_k127_6554931_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 574.0
HFD2_k127_6554931_10 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000008057 231.0
HFD2_k127_6554931_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000002069 213.0
HFD2_k127_6554931_12 Protein of unknown function (DUF1571) - - - 0.000000000000000000000000000000000000000004765 164.0
HFD2_k127_6554931_13 4Fe-4S binding domain - - - 0.00000000000000001151 83.0
HFD2_k127_6554931_14 Domain of unknown function (DUF1844) - - - 0.00000000000000003702 84.0
HFD2_k127_6554931_15 peptidyl-prolyl isomerase K07533 - 5.2.1.8 0.0000002572 61.0
HFD2_k127_6554931_2 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 412.0
HFD2_k127_6554931_3 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 409.0
HFD2_k127_6554931_4 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 347.0
HFD2_k127_6554931_5 Ribosomal protein S2 K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 334.0
HFD2_k127_6554931_6 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 325.0
HFD2_k127_6554931_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 295.0
HFD2_k127_6554931_8 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 318.0
HFD2_k127_6554931_9 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002994 283.0
HFD2_k127_6584655_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 588.0
HFD2_k127_6584655_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 576.0
HFD2_k127_6584655_10 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000005154 163.0
HFD2_k127_6584655_11 Transcription termination factor nusG - - - 0.000000000000000000000000000000000000000004245 171.0
HFD2_k127_6584655_12 Parallel beta-helix repeats - - - 0.0000000004708 74.0
HFD2_k127_6584655_2 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 533.0
HFD2_k127_6584655_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 447.0
HFD2_k127_6584655_4 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 434.0
HFD2_k127_6584655_5 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 342.0
HFD2_k127_6584655_6 Alpha-tubulin suppressor and related RCC1 domain-containing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 371.0
HFD2_k127_6584655_7 PQQ-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 344.0
HFD2_k127_6584655_8 Transcriptional regulator K18136 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000006415 229.0
HFD2_k127_6584655_9 PEP-CTERM motif - - - 0.000000000000000000000000000000000000000000006237 172.0
HFD2_k127_6681287_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K00533,K05922,K06281 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.5.1,1.12.7.2,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 586.0
HFD2_k127_6681287_1 Hydrogenase (NiFe) small subunit HydA K05927,K06282,K18008 - 1.12.2.1,1.12.5.1,1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 312.0
HFD2_k127_6681287_10 Adenylylsulphate kinase K00860 - 2.7.1.25 0.00000000000000000000000000000000000002535 152.0
HFD2_k127_6681287_11 TIGRFAM Ni Fe-hydrogenase, b-type cytochrome subunit K03620 - - 0.00000000000000000000000000483 119.0
HFD2_k127_6681287_12 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000003039 109.0
HFD2_k127_6681287_13 virion core protein (lumpy skin disease virus) - - - 0.0000000000000000006871 88.0
HFD2_k127_6681287_14 ParE-like toxin of type II bacterial toxin-antitoxin system - - - 0.0000000000000001257 82.0
HFD2_k127_6681287_15 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0000000000000002957 80.0
HFD2_k127_6681287_16 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000001395 78.0
HFD2_k127_6681287_17 - - - - 0.000000000000005192 75.0
HFD2_k127_6681287_2 precorrin-4 C11-methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 305.0
HFD2_k127_6681287_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 309.0
HFD2_k127_6681287_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 301.0
HFD2_k127_6681287_5 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002008 287.0
HFD2_k127_6681287_6 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005443 284.0
HFD2_k127_6681287_7 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K13541,K21479 - 2.1.1.131,2.1.1.272,3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000002412 257.0
HFD2_k127_6681287_8 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000001716 225.0
HFD2_k127_6681287_9 hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000000000009107 156.0
HFD2_k127_6704328_0 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 4.217e-205 648.0
HFD2_k127_6704328_1 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 389.0
HFD2_k127_6704328_2 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.0000000000000000002804 93.0
HFD2_k127_6885346_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 9.17e-202 655.0
HFD2_k127_6885346_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 309.0
HFD2_k127_6885346_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000002567 231.0
HFD2_k127_6885346_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.000000000000000000000000000000000174 146.0
HFD2_k127_6885346_4 - - - - 0.00000000000000000002054 99.0
HFD2_k127_6904433_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.173e-294 923.0
HFD2_k127_6904433_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 512.0
HFD2_k127_6904433_2 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003774 288.0
HFD2_k127_6904433_3 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.00000000000004397 85.0
HFD2_k127_6904433_4 response regulator - - - 0.00000001294 64.0
HFD2_k127_6906408_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 535.0
HFD2_k127_6906408_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000005044 235.0
HFD2_k127_6906408_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000005447 211.0
HFD2_k127_6906408_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000003648 130.0
HFD2_k127_6906408_4 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000006313 98.0
HFD2_k127_6989052_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 391.0
HFD2_k127_6989052_1 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 323.0
HFD2_k127_6989052_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000007143 213.0
HFD2_k127_6989052_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000004725 98.0
HFD2_k127_6989052_4 HMGL-like - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450 - 0.0000000000000000000007086 98.0
HFD2_k127_6989052_5 PFAM YcfA-like protein - - - 0.0000000008166 61.0
HFD2_k127_699151_0 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 320.0
HFD2_k127_699151_1 EamA-like transporter family - - - 0.0000000000000000000000001844 111.0
HFD2_k127_699151_2 Lipid A 3-O-deacylase (PagL) - - - 0.000000000000005519 86.0
HFD2_k127_699151_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000001888 71.0
HFD2_k127_699151_4 Tetratricopeptide repeat - - - 0.0001518 52.0
HFD2_k127_7034408_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 603.0
HFD2_k127_7034408_1 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 303.0
HFD2_k127_7034408_2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000001345 237.0
HFD2_k127_7034408_3 PTS system fructose IIA component K02793 - 2.7.1.191 0.0000000000000000000000000000001342 128.0
HFD2_k127_7034408_4 TIGRFAM phosphocarrier, HPr family K11189 - - 0.000000000000000000000005603 103.0
HFD2_k127_7034408_5 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000001273 103.0
HFD2_k127_7072074_0 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 425.0
HFD2_k127_7072074_1 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 312.0
HFD2_k127_7072074_2 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000001868 248.0
HFD2_k127_7072074_3 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000003597 226.0
HFD2_k127_707462_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 2.808e-204 652.0
HFD2_k127_707462_1 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 367.0
HFD2_k127_707462_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000233 268.0
HFD2_k127_707462_3 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000003887 213.0
HFD2_k127_707462_4 Psort location Cytoplasmic, score 8.96 K01163 - - 0.00000000000000000000000000000000000000000000000000000000003246 217.0
HFD2_k127_707462_5 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000008357 164.0
HFD2_k127_707462_6 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.0000000000000000000000000000000000009348 147.0
HFD2_k127_707462_7 Protein of unknown function (DUF2283) - - - 0.000000000000000000000000004803 112.0
HFD2_k127_707462_8 Protein of unknown function (DUF721) - - - 0.0000000000000167 80.0
HFD2_k127_7183360_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K05551 - 2.3.1.235,2.3.1.260 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 429.0
HFD2_k127_7183360_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 302.0
HFD2_k127_7183360_2 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004157 280.0
HFD2_k127_7183360_3 negative regulation of translational initiation K05554,K14670 - - 0.000000000000000000000000000000000002784 141.0
HFD2_k127_7183360_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000003227 126.0
HFD2_k127_7183360_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000001355 68.0
HFD2_k127_7187088_0 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00239 - 1.3.5.1,1.3.5.4 2.757e-262 818.0
HFD2_k127_7187088_1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000004655 173.0
HFD2_k127_7192075_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 8.739e-255 795.0
HFD2_k127_7192075_1 glucan 1,4-alpha-glucosidase activity - - - 1.555e-247 781.0
HFD2_k127_7192075_10 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 319.0
HFD2_k127_7192075_11 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002843 280.0
HFD2_k127_7192075_12 acetyltransferase K18815 - 2.3.1.82 0.00000000000000000000000000000000000000000000000000003499 192.0
HFD2_k127_7192075_13 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.00000000000000000000000000000000000000000000000000007433 194.0
HFD2_k127_7192075_14 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000009207 156.0
HFD2_k127_7192075_15 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000002137 149.0
HFD2_k127_7192075_16 Protein of unknown function, DUF485 - - - 0.00000000000000000000000000001885 120.0
HFD2_k127_7192075_19 phosphate-selective porin O and P K07221 - - 0.0000000003208 73.0
HFD2_k127_7192075_2 glycolate transport K14393 - - 2.434e-242 761.0
HFD2_k127_7192075_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 7.724e-237 748.0
HFD2_k127_7192075_4 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 548.0
HFD2_k127_7192075_5 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 437.0
HFD2_k127_7192075_6 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 426.0
HFD2_k127_7192075_7 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 381.0
HFD2_k127_7192075_8 Pyridine nucleotide-disulphide oxidoreductase K00529,K18227,K18249 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 359.0
HFD2_k127_7192075_9 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 329.0
HFD2_k127_7255041_0 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000939 392.0
HFD2_k127_7255041_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 302.0
HFD2_k127_7255041_10 Tetratricopeptide repeat - - - 0.0000000000000002701 89.0
HFD2_k127_7255041_11 phosphate-selective porin O and P K07221 - - 0.0000000000002539 83.0
HFD2_k127_7255041_12 protein secretion K03116,K03117 - - 0.0000000000003448 74.0
HFD2_k127_7255041_2 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001711 280.0
HFD2_k127_7255041_3 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001314 257.0
HFD2_k127_7255041_4 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000001696 231.0
HFD2_k127_7255041_5 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.0000000000000000000000000000000000000000000000000000000000002477 225.0
HFD2_k127_7255041_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000002356 212.0
HFD2_k127_7255041_7 phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000004954 158.0
HFD2_k127_7255041_8 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000006192 154.0
HFD2_k127_7255041_9 - - - - 0.0000000000000000001776 91.0
HFD2_k127_7272608_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.334e-264 833.0
HFD2_k127_7272608_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.136e-217 697.0
HFD2_k127_7272608_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006703 424.0
HFD2_k127_7272608_11 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000601 394.0
HFD2_k127_7272608_12 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 390.0
HFD2_k127_7272608_13 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074,K12257 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 351.0
HFD2_k127_7272608_14 PFAM Electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 327.0
HFD2_k127_7272608_15 cytochrome C family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 316.0
HFD2_k127_7272608_16 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 312.0
HFD2_k127_7272608_17 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 318.0
HFD2_k127_7272608_18 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 319.0
HFD2_k127_7272608_19 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 303.0
HFD2_k127_7272608_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009702 584.0
HFD2_k127_7272608_20 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 314.0
HFD2_k127_7272608_21 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002113 266.0
HFD2_k127_7272608_22 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001142 268.0
HFD2_k127_7272608_23 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000001659 258.0
HFD2_k127_7272608_24 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000007399 244.0
HFD2_k127_7272608_25 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000001338 204.0
HFD2_k127_7272608_26 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.0000000000000000000000000000000000000000000000000000003331 201.0
HFD2_k127_7272608_27 Autoinducer binding domain K20334 - - 0.000000000000000000000000000000000000000000000000000009334 197.0
HFD2_k127_7272608_28 Endoribonuclease L-PSP K09022 GO:0003674,GO:0003824,GO:0016787,GO:0019239 3.5.99.10 0.0000000000000000000000000000000000000000000000004308 177.0
HFD2_k127_7272608_29 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000000003065 177.0
HFD2_k127_7272608_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 580.0
HFD2_k127_7272608_30 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000191 164.0
HFD2_k127_7272608_31 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000002276 165.0
HFD2_k127_7272608_32 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000007793 164.0
HFD2_k127_7272608_33 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000001836 142.0
HFD2_k127_7272608_34 Preprotein translocase subunit K03210 - - 0.00000000000000000000000000000125 124.0
HFD2_k127_7272608_35 Universal stress protein family K07090 - - 0.00000000000000000000000000422 125.0
HFD2_k127_7272608_36 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000004659 106.0
HFD2_k127_7272608_37 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000002377 97.0
HFD2_k127_7272608_38 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000002718 98.0
HFD2_k127_7272608_39 structural constituent of ribosome K02911 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000002243 83.0
HFD2_k127_7272608_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008416 558.0
HFD2_k127_7272608_40 - - - - 0.0000000000000007242 87.0
HFD2_k127_7272608_41 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000003802 76.0
HFD2_k127_7272608_42 Autoinducer synthase - - - 0.000000002395 67.0
HFD2_k127_7272608_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 549.0
HFD2_k127_7272608_6 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 470.0
HFD2_k127_7272608_7 DHH family K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 480.0
HFD2_k127_7272608_8 Electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 454.0
HFD2_k127_7272608_9 pyridine nucleotide-disulphide oxidoreductase dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 438.0
HFD2_k127_7307656_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 497.0
HFD2_k127_7307656_1 FAD linked oxidase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 477.0
HFD2_k127_7307656_10 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000002109 186.0
HFD2_k127_7307656_11 Chromate transporter K07240 - - 0.00000000000000000000000000000003819 139.0
HFD2_k127_7307656_12 PFAM Nitrous oxide-stimulated promoter - - - 0.00000000000000000000000000000004863 128.0
HFD2_k127_7307656_13 Chromate transport protein K07240 - - 0.000000000000000000000000000002925 128.0
HFD2_k127_7307656_14 TIGRFAM thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000002314 116.0
HFD2_k127_7307656_15 Tetratricopeptide repeat - - - 0.00000000000000000000754 101.0
HFD2_k127_7307656_16 sensor protein - - - 0.000000000000000001013 101.0
HFD2_k127_7307656_17 Putative regulatory protein - - - 0.0000000000000004892 80.0
HFD2_k127_7307656_18 - - - - 0.000000000000004536 88.0
HFD2_k127_7307656_19 Universal stress protein family K07090 - - 0.0000000000000124 86.0
HFD2_k127_7307656_2 cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 381.0
HFD2_k127_7307656_20 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000007934 72.0
HFD2_k127_7307656_21 monooxygenase activity - - - 0.00000000005155 66.0
HFD2_k127_7307656_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 296.0
HFD2_k127_7307656_4 Fe-S oxidoreductase K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005514 283.0
HFD2_k127_7307656_5 TIGRFAM TIGR00268 family protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002359 248.0
HFD2_k127_7307656_6 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000002064 229.0
HFD2_k127_7307656_7 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000001585 214.0
HFD2_k127_7307656_8 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000001054 205.0
HFD2_k127_7307656_9 GAF domain - - - 0.00000000000000000000000000000000000000000000001723 185.0
HFD2_k127_732061_0 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 532.0
HFD2_k127_732061_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000001403 109.0
HFD2_k127_732061_3 Radical SAM superfamily K04070 - 1.97.1.4 0.00009728 45.0
HFD2_k127_7349674_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 615.0
HFD2_k127_7349674_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 295.0
HFD2_k127_7349674_2 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000002387 203.0
HFD2_k127_7349674_3 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000001305 189.0
HFD2_k127_7349674_4 Ribosomal protein L30p/L7e K02907 - - 0.0000000000000004671 80.0
HFD2_k127_7454642_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 381.0
HFD2_k127_7454642_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 363.0
HFD2_k127_7524125_0 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 343.0
HFD2_k127_7524125_1 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005667 286.0
HFD2_k127_7524125_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000008121 235.0
HFD2_k127_7524125_3 Polypeptide deformylase K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000001017 191.0
HFD2_k127_7524125_4 Domain of unknown function (DUF4082) - - - 0.0000000000000001317 93.0
HFD2_k127_7524125_5 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.0000000000008586 81.0
HFD2_k127_7540206_0 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004363 276.0
HFD2_k127_7540206_1 O-methyltransferase activity K05303 - - 0.00000000000000000000000000000000002395 145.0
HFD2_k127_7540206_2 Polysaccharide deacetylase - - - 0.0000000000000000000001627 114.0
HFD2_k127_7540206_3 polysaccharide biosynthetic process - - - 0.0003221 54.0
HFD2_k127_7541830_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 401.0
HFD2_k127_7541830_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 348.0
HFD2_k127_7541830_10 Methyltransferase type 12 - - - 0.00000000000000000000000000000000001009 149.0
HFD2_k127_7541830_11 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000002156 132.0
HFD2_k127_7541830_12 Oligosaccharide biosynthesis protein Alg14 like - - - 0.00000000000000000000000011 114.0
HFD2_k127_7541830_13 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000006706 113.0
HFD2_k127_7541830_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000002354 119.0
HFD2_k127_7541830_15 PFAM Methyltransferase type 11 - - - 0.00000000000000000000009707 114.0
HFD2_k127_7541830_16 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000000783 93.0
HFD2_k127_7541830_17 Uncharacterized conserved protein (DUF2304) K09153 - - 0.0000000000000000001033 93.0
HFD2_k127_7541830_18 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000003621 75.0
HFD2_k127_7541830_19 lysyltransferase activity K07027 - - 0.00006274 54.0
HFD2_k127_7541830_2 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 306.0
HFD2_k127_7541830_3 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 297.0
HFD2_k127_7541830_4 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001226 267.0
HFD2_k127_7541830_5 Glycosyl transferase family 2 K00786 - - 0.00000000000000000000000000000000000000000000000000000000000000000001143 243.0
HFD2_k127_7541830_6 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000002186 235.0
HFD2_k127_7541830_7 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000005464 199.0
HFD2_k127_7541830_8 Conserved hypothetical protein 95 - - - 0.000000000000000000000000000000000000001336 154.0
HFD2_k127_7541830_9 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000000000000000000000000000000004515 145.0
HFD2_k127_7588487_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.33e-303 950.0
HFD2_k127_7588487_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 2.999e-294 915.0
HFD2_k127_7588487_10 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 401.0
HFD2_k127_7588487_11 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 363.0
HFD2_k127_7588487_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004226 330.0
HFD2_k127_7588487_13 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 325.0
HFD2_k127_7588487_14 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 310.0
HFD2_k127_7588487_15 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 302.0
HFD2_k127_7588487_16 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 318.0
HFD2_k127_7588487_17 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001624 287.0
HFD2_k127_7588487_18 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003023 280.0
HFD2_k127_7588487_19 Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004267 280.0
HFD2_k127_7588487_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.173e-205 648.0
HFD2_k127_7588487_20 PFAM MscS Mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 267.0
HFD2_k127_7588487_21 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000003924 225.0
HFD2_k127_7588487_22 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000001412 223.0
HFD2_k127_7588487_23 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000004935 194.0
HFD2_k127_7588487_24 PFAM Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000005454 169.0
HFD2_k127_7588487_25 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000001382 153.0
HFD2_k127_7588487_26 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000000002439 151.0
HFD2_k127_7588487_27 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000007303 117.0
HFD2_k127_7588487_28 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000143 122.0
HFD2_k127_7588487_29 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000001123 108.0
HFD2_k127_7588487_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 5.323e-196 618.0
HFD2_k127_7588487_30 CHAT domain - - - 0.000000000000000000001499 105.0
HFD2_k127_7588487_31 Protein of unknown function, DUF488 - - - 0.0000000000001682 75.0
HFD2_k127_7588487_32 cog cog3189 - - - 0.000000000182 67.0
HFD2_k127_7588487_4 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 616.0
HFD2_k127_7588487_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 592.0
HFD2_k127_7588487_6 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 578.0
HFD2_k127_7588487_7 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 511.0
HFD2_k127_7588487_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 490.0
HFD2_k127_7588487_9 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 400.0
HFD2_k127_761537_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1517.0
HFD2_k127_761537_1 BadF BadG BcrA BcrD - - - 0.0 1446.0
HFD2_k127_761537_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 346.0
HFD2_k127_761537_11 Hydrogenase expression formation protein (HypE) K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 329.0
HFD2_k127_761537_12 PFAM Sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 297.0
HFD2_k127_761537_13 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005176 258.0
HFD2_k127_761537_14 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000009719 194.0
HFD2_k127_761537_15 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000000000000000000000000000000000000000002319 192.0
HFD2_k127_761537_16 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000001029 214.0
HFD2_k127_761537_17 Protein of unknown function (DUF1318) K09978 - - 0.00000000000000000000000000000000000005009 151.0
HFD2_k127_761537_18 Thiamine-binding protein - - - 0.00000000000000000000000000006045 121.0
HFD2_k127_761537_19 - - - - 0.00000003371 59.0
HFD2_k127_761537_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.433e-199 627.0
HFD2_k127_761537_20 - - - - 0.00009637 49.0
HFD2_k127_761537_21 Histidine kinase - - - 0.0001873 51.0
HFD2_k127_761537_3 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 592.0
HFD2_k127_761537_4 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 518.0
HFD2_k127_761537_5 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 510.0
HFD2_k127_761537_6 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 508.0
HFD2_k127_761537_7 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 474.0
HFD2_k127_761537_8 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 387.0
HFD2_k127_761537_9 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 369.0
HFD2_k127_7624178_0 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 380.0
HFD2_k127_7624178_1 BadF BadG BcrA BcrD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002923 278.0
HFD2_k127_7624178_2 NAD- dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000002163 130.0
HFD2_k127_7624178_3 transmembrane signaling receptor activity K02660,K03406,K03776,K11525 - - 0.0000000000000000000000000000003757 130.0
HFD2_k127_7624178_4 - - - - 0.0002837 50.0
HFD2_k127_7637430_0 Molybdopterin oxidoreductase Fe4S4 domain K00123,K05299 - 1.17.1.10,1.17.1.9 1.238e-285 912.0
HFD2_k127_7637430_1 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 2.938e-240 760.0
HFD2_k127_7637430_10 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 418.0
HFD2_k127_7637430_11 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 407.0
HFD2_k127_7637430_12 His Kinase A (phosphoacceptor) domain K02484,K07636,K07768 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 411.0
HFD2_k127_7637430_13 phosphate ion binding K02040 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 385.0
HFD2_k127_7637430_14 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 372.0
HFD2_k127_7637430_15 transferase activity, transferring glycosyl groups K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005587 366.0
HFD2_k127_7637430_16 PHP domain protein K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 349.0
HFD2_k127_7637430_17 Ion transport 2 domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 351.0
HFD2_k127_7637430_18 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 344.0
HFD2_k127_7637430_2 Pyridine nucleotide-disulphide oxidoreductase K15022 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.17.1.10 8.392e-239 753.0
HFD2_k127_7637430_20 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 324.0
HFD2_k127_7637430_21 PFAM MltA K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 318.0
HFD2_k127_7637430_22 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 308.0
HFD2_k127_7637430_23 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 309.0
HFD2_k127_7637430_24 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000174 277.0
HFD2_k127_7637430_25 Evidence 4 Homologs of previously reported genes of K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002738 278.0
HFD2_k127_7637430_26 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007117 272.0
HFD2_k127_7637430_27 Phosphate transport system permease protein PstA K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007359 285.0
HFD2_k127_7637430_28 PFAM response regulator receiver K07657,K07659,K07664,K11329 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006393 264.0
HFD2_k127_7637430_29 Tetrapyrrole (Corrin/Porphyrin) Methylases K01719,K01749,K02303,K13542,K13543 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000004199 248.0
HFD2_k127_7637430_3 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 5.934e-216 685.0
HFD2_k127_7637430_30 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000001308 248.0
HFD2_k127_7637430_31 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000009191 240.0
HFD2_k127_7637430_32 PFAM Stage II sporulation K06381 - - 0.000000000000000000000000000000000000000000000000000000000000000000009797 247.0
HFD2_k127_7637430_33 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001909 239.0
HFD2_k127_7637430_34 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000006981 237.0
HFD2_k127_7637430_35 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000004234 223.0
HFD2_k127_7637430_36 MOSC domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000009064 219.0
HFD2_k127_7637430_37 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001189 229.0
HFD2_k127_7637430_38 molybdenum cofactor - - - 0.00000000000000000000000000000000000000000000000000000000004326 209.0
HFD2_k127_7637430_39 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000000000000000000131 221.0
HFD2_k127_7637430_4 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 504.0
HFD2_k127_7637430_40 - - - - 0.0000000000000000000000000000000000000000000000007705 186.0
HFD2_k127_7637430_41 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000001383 163.0
HFD2_k127_7637430_42 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000000000000000005013 177.0
HFD2_k127_7637430_43 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000001741 167.0
HFD2_k127_7637430_44 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000001714 151.0
HFD2_k127_7637430_45 COG2143 Thioredoxin-related protein - - - 0.0000000000000000000000000000000002789 138.0
HFD2_k127_7637430_46 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000001048 142.0
HFD2_k127_7637430_47 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000001932 134.0
HFD2_k127_7637430_48 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000000003534 132.0
HFD2_k127_7637430_49 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000000000000000000002027 139.0
HFD2_k127_7637430_5 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 463.0
HFD2_k127_7637430_50 COG2143 Thioredoxin-related protein - - - 0.00000000000000000000001133 112.0
HFD2_k127_7637430_51 Insulinase (Peptidase family M16) - - - 0.0000000000000000000001278 112.0
HFD2_k127_7637430_52 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000001745 105.0
HFD2_k127_7637430_53 OsmC-like protein K07397 - - 0.0000000000000000000007556 101.0
HFD2_k127_7637430_54 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000003485 93.0
HFD2_k127_7637430_55 Protein of unknown function (DUF2905) - - - 0.000000000000000002415 86.0
HFD2_k127_7637430_56 Protein of unknown function, DUF255 K04084 - 1.8.1.8 0.000000000000000005592 89.0
HFD2_k127_7637430_57 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000002026 87.0
HFD2_k127_7637430_58 PFAM Heavy metal transport detoxification protein K07213 - - 0.00000000000001215 76.0
HFD2_k127_7637430_59 - - - - 0.0000000000004739 79.0
HFD2_k127_7637430_6 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 463.0
HFD2_k127_7637430_60 monooxygenase activity K06966 - 3.2.2.10 0.000000001584 70.0
HFD2_k127_7637430_61 HEPN domain - - - 0.0000001258 59.0
HFD2_k127_7637430_64 - - - - 0.000001448 59.0
HFD2_k127_7637430_65 Sporulation related domain - - - 0.00003004 54.0
HFD2_k127_7637430_7 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 454.0
HFD2_k127_7637430_8 Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 426.0
HFD2_k127_7637430_9 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 424.0
HFD2_k127_7745101_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 4.826e-201 636.0
HFD2_k127_7745101_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007968 599.0
HFD2_k127_7745101_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 363.0
HFD2_k127_7745101_3 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001027 252.0
HFD2_k127_7745101_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000005477 218.0
HFD2_k127_7745101_5 Domain of unknown function (DUF370) K09777 - - 0.00000000000000000000000000000002038 127.0
HFD2_k127_7745101_6 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0001221 50.0
HFD2_k127_7757609_0 AcrB/AcrD/AcrF family K03296,K19594 - - 0.0 1549.0
HFD2_k127_7757609_1 Sulfatase K01130 - 3.1.6.1 0.0 1302.0
HFD2_k127_7757609_2 COG2015, Alkyl sulfatase and related hydrolases - - - 2.224e-317 984.0
HFD2_k127_7757609_3 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 4.656e-304 940.0
HFD2_k127_7757609_4 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 533.0
HFD2_k127_7757609_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 476.0
HFD2_k127_7757609_6 Catalytic domain of components of various dehydrogenase complexes K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 445.0
HFD2_k127_7757609_7 Biotin-lipoyl like K19595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 426.0
HFD2_k127_7757609_8 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.00000000000000000000002166 103.0
HFD2_k127_7757609_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000000000000003298 91.0
HFD2_k127_7833714_0 Amino acid permease - - - 1.335e-241 764.0
HFD2_k127_7833714_1 TIGRFAM lysine 2,3-aminomutase YodO family protein K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 527.0
HFD2_k127_7833714_2 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 445.0
HFD2_k127_7833714_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000004445 83.0
HFD2_k127_7887108_0 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 469.0
HFD2_k127_7887108_1 PFAM SPFH domain Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 339.0
HFD2_k127_7887108_2 PFAM Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 261.0
HFD2_k127_7887108_3 Peptidase family M23 K21471 GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000000000001652 200.0
HFD2_k127_7887108_4 Psort location Cytoplasmic, score - - - 0.0000000000000002649 92.0
HFD2_k127_7887108_5 SPFH domain-Band 7 family - - - 0.000000006312 57.0
HFD2_k127_7906130_0 2-oxoisovalerate dehydrogenase K00167,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 370.0
HFD2_k127_7906130_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009077 357.0
HFD2_k127_7906130_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004833 277.0
HFD2_k127_7906130_3 Tryptophanyl-tRNA synthetase K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.0000000000000000000000000000000000000000000000000000003332 202.0
HFD2_k127_7918040_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 532.0
HFD2_k127_7918040_1 GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 513.0
HFD2_k127_7918040_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008623 279.0
HFD2_k127_7918040_3 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000001217 169.0
HFD2_k127_7918040_4 PFAM phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000008948 51.0
HFD2_k127_7929398_0 Protein involved in outer membrane biogenesis - - - 2.399e-262 850.0
HFD2_k127_7929398_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 567.0
HFD2_k127_7929398_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000000000000000000004656 201.0
HFD2_k127_7929398_4 transcriptional regulator K16137 - - 0.00000000000000000000000000000007514 135.0
HFD2_k127_7929398_5 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000000000000000000004305 128.0
HFD2_k127_7929398_6 Domain of unknown function (DUF4410) - - - 0.00000000000001003 84.0
HFD2_k127_7929398_7 negative regulation of translational initiation K05554,K15885 - - 0.00000000001454 72.0
HFD2_k127_7929398_8 transglutaminase domain protein - - - 0.000000005287 59.0
HFD2_k127_7929398_9 Ankyrin repeat - GO:0001726,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005856,GO:0005874,GO:0005886,GO:0005911,GO:0005912,GO:0005924,GO:0005927,GO:0006996,GO:0007010,GO:0007162,GO:0007275,GO:0007399,GO:0008013,GO:0008017,GO:0008064,GO:0008092,GO:0008104,GO:0008150,GO:0009653,GO:0009790,GO:0009792,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010639,GO:0010646,GO:0010647,GO:0010648,GO:0010721,GO:0010769,GO:0010771,GO:0010810,GO:0010812,GO:0010975,GO:0010977,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0022008,GO:0022603,GO:0022604,GO:0023051,GO:0023056,GO:0023057,GO:0030029,GO:0030036,GO:0030054,GO:0030055,GO:0030056,GO:0030111,GO:0030154,GO:0030155,GO:0030177,GO:0030334,GO:0030336,GO:0030832,GO:0030833,GO:0030837,GO:0031252,GO:0031253,GO:0031256,GO:0031333,GO:0031344,GO:0031345,GO:0032271,GO:0032272,GO:0032501,GO:0032502,GO:0032535,GO:0032587,GO:0032878,GO:0032879,GO:0032956,GO:0032970,GO:0033036,GO:0033043,GO:0034330,GO:0034331,GO:0035023,GO:0035024,GO:0035371,GO:0040012,GO:0040013,GO:0042995,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043254,GO:0043954,GO:0044087,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0045216,GO:0045217,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0046578,GO:0046580,GO:0046626,GO:0046627,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048598,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0051010,GO:0051056,GO:0051058,GO:0051093,GO:0051128,GO:0051129,GO:0051179,GO:0051239,GO:0051241,GO:0051270,GO:0051271,GO:0051493,GO:0051494,GO:0051960,GO:0051961,GO:0060284,GO:0060491,GO:0060828,GO:0061041,GO:0065007,GO:0065008,GO:0070161,GO:0071840,GO:0071944,GO:0080134,GO:0090066,GO:0090263,GO:0090303,GO:0098590,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0110053,GO:0120025,GO:0120032,GO:0120033,GO:0120035,GO:0120038,GO:1900024,GO:1900025,GO:1900027,GO:1900028,GO:1900076,GO:1900077,GO:1902531,GO:1902532,GO:1902743,GO:1902744,GO:1902903,GO:1902904,GO:1903034,GO:1903036,GO:1990752,GO:2000026,GO:2000114,GO:2000145,GO:2000146,GO:2000392,GO:2000393 - 0.000005226 55.0
HFD2_k127_7933838_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 6.406e-204 645.0
HFD2_k127_7933838_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 3.311e-202 639.0
HFD2_k127_7933838_2 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000000000000007649 176.0
HFD2_k127_7933838_3 Protein of unknown function (DUF559) - - - 0.0000000000000000000000000009764 117.0
HFD2_k127_7933838_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000005208 111.0
HFD2_k127_7935620_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1341.0
HFD2_k127_7935620_1 Large extracellular alpha-helical protein K06894 - - 1.172e-308 1009.0
HFD2_k127_7935620_2 penicillin binding K05367 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 551.0
HFD2_k127_7935620_3 phosphorelay signal transduction system K02584,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 469.0
HFD2_k127_7935620_4 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 348.0
HFD2_k127_7956145_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 454.0
HFD2_k127_7956145_1 pfam abc K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 331.0
HFD2_k127_7956145_2 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001257 276.0
HFD2_k127_7956145_3 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001618 261.0
HFD2_k127_7956145_4 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000006648 240.0
HFD2_k127_7956145_5 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000009615 155.0
HFD2_k127_7956145_6 - - - - 0.00000000000000000005 101.0
HFD2_k127_7956145_8 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000001045 50.0
HFD2_k127_7982152_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 8.616e-247 780.0
HFD2_k127_7982152_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000002758 198.0
HFD2_k127_7982152_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000005226 169.0
HFD2_k127_7982152_3 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000005048 143.0
HFD2_k127_7982152_4 PFAM purine or other phosphorylase family 1 K01243 - 3.2.2.9 0.00000000000000001448 94.0
HFD2_k127_7982152_5 peroxiredoxin activity K01607 - 4.1.1.44 0.00000005767 57.0
HFD2_k127_8099490_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 527.0
HFD2_k127_8099490_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 432.0
HFD2_k127_8099490_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 420.0
HFD2_k127_8099490_3 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002743 261.0
HFD2_k127_8099490_4 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003375 246.0
HFD2_k127_8099490_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000008605 244.0
HFD2_k127_8099490_6 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000001293 182.0
HFD2_k127_8099490_7 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000008161 174.0
HFD2_k127_8099490_8 regulatory protein RecX K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000004497 89.0
HFD2_k127_8099490_9 Protein of unknown function, DUF255 K06888 - - 0.00000002173 66.0
HFD2_k127_8114086_0 Heat shock 70 kDa protein K04043 - - 6.94e-311 963.0
HFD2_k127_8114086_1 CBS domain containing protein K00974 - 2.7.7.72 2.134e-275 872.0
HFD2_k127_8114086_10 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 378.0
HFD2_k127_8114086_11 B12 binding domain K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 378.0
HFD2_k127_8114086_12 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008209 375.0
HFD2_k127_8114086_13 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 342.0
HFD2_k127_8114086_14 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 319.0
HFD2_k127_8114086_15 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 313.0
HFD2_k127_8114086_16 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 311.0
HFD2_k127_8114086_17 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 294.0
HFD2_k127_8114086_18 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003308 276.0
HFD2_k127_8114086_19 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000008565 250.0
HFD2_k127_8114086_2 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 2.209e-217 688.0
HFD2_k127_8114086_20 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004352 248.0
HFD2_k127_8114086_21 -O-antigen K02847,K13009,K16705 GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000002143 257.0
HFD2_k127_8114086_22 - - - - 0.000000000000000000000000000000000000000000000000000000000000000169 230.0
HFD2_k127_8114086_23 RNA-binding protein homologous to eukaryotic snRNP - - - 0.00000000000000000000000000000000000000000000000000000000000000111 239.0
HFD2_k127_8114086_24 hopanoid biosynthesis associated protein HpnK - - - 0.00000000000000000000000000000000000000000000000000000000001257 217.0
HFD2_k127_8114086_25 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000002081 203.0
HFD2_k127_8114086_26 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000001384 214.0
HFD2_k127_8114086_27 permease - - - 0.0000000000000000000000000000000000000000000000000000001774 213.0
HFD2_k127_8114086_28 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000006237 201.0
HFD2_k127_8114086_29 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000005767 201.0
HFD2_k127_8114086_3 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007228 580.0
HFD2_k127_8114086_30 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000008434 196.0
HFD2_k127_8114086_31 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000000000000000000000000000001544 179.0
HFD2_k127_8114086_32 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.00000000000000000000000000000000000007917 149.0
HFD2_k127_8114086_33 Glycosyltransferase family 87 - - - 0.00000000000000000000000000000004143 139.0
HFD2_k127_8114086_34 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000000003028 135.0
HFD2_k127_8114086_35 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0000000000000000000000001996 111.0
HFD2_k127_8114086_36 Type IV pilin PilA K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000000000000000000000001604 108.0
HFD2_k127_8114086_37 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000000000000000000002268 100.0
HFD2_k127_8114086_38 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000007392 95.0
HFD2_k127_8114086_39 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000009459 89.0
HFD2_k127_8114086_4 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009478 501.0
HFD2_k127_8114086_40 - - - - 0.0000000000000003777 85.0
HFD2_k127_8114086_41 bicarbonate transporter, IctB family K18814 - - 0.0000000000000088 88.0
HFD2_k127_8114086_5 phosphorelay signal transduction system K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 522.0
HFD2_k127_8114086_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000669 479.0
HFD2_k127_8114086_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 407.0
HFD2_k127_8114086_8 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 402.0
HFD2_k127_8114086_9 Fe-S oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 383.0
HFD2_k127_8206063_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 608.0
HFD2_k127_8206063_1 PFAM nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 582.0
HFD2_k127_8206063_10 Rubrerythrin - - - 0.000000002187 65.0
HFD2_k127_8206063_2 TIGRFAM sulfite reductase, dissimilatory-type beta subunit K11181 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 518.0
HFD2_k127_8206063_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 525.0
HFD2_k127_8206063_4 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528,K16951 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 339.0
HFD2_k127_8206063_5 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000001727 248.0
HFD2_k127_8206063_6 part of a sulfur-relay system K11179 - - 0.0000000000000000000000002084 114.0
HFD2_k127_8206063_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000761 112.0
HFD2_k127_8206063_8 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000003544 83.0
HFD2_k127_8206063_9 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000002659 85.0
HFD2_k127_8217250_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 5.159e-298 951.0
HFD2_k127_8217250_1 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000000000147 193.0
HFD2_k127_8217250_2 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000102 190.0
HFD2_k127_8217250_3 Yip1 domain - - - 0.00001554 55.0
HFD2_k127_8228863_0 Family 5 K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 374.0
HFD2_k127_8228863_1 Amidohydrolase family K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000105 287.0
HFD2_k127_8228863_2 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000007619 180.0
HFD2_k127_8228863_3 COGs COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system - - - 0.0000000000003238 79.0
HFD2_k127_8234140_0 Belongs to the carbamoyltransferase HypF family K04656 - - 4.355e-212 679.0
HFD2_k127_8234140_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 484.0
HFD2_k127_8234140_2 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000781 230.0
HFD2_k127_8234140_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000002785 156.0
HFD2_k127_8241740_0 PFAM ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 581.0
HFD2_k127_8241740_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 375.0
HFD2_k127_8241740_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 344.0
HFD2_k127_8253617_0 Multicopper oxidase K06324 - 1.16.3.3 1.514e-202 655.0
HFD2_k127_8253617_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 389.0
HFD2_k127_8253617_2 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004165 287.0
HFD2_k127_8253617_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003495 239.0
HFD2_k127_8253617_4 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000005478 85.0
HFD2_k127_8273446_0 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 509.0
HFD2_k127_8273446_1 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008146 235.0
HFD2_k127_8273446_2 - - - - 0.000000000000000000000000000000000000000000000000000000008867 208.0
HFD2_k127_8273446_3 - - - - 0.000000000000000000000000000000000000000000000000000001497 205.0
HFD2_k127_8273446_4 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000004446 106.0
HFD2_k127_8321331_0 SMART Elongator protein 3 MiaB NifB - - - 3.693e-244 782.0
HFD2_k127_8321331_1 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 5.24e-203 643.0
HFD2_k127_8321331_10 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000001877 186.0
HFD2_k127_8321331_11 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.00000000000000000000000000000001569 130.0
HFD2_k127_8321331_12 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000007343 130.0
HFD2_k127_8321331_13 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000002245 121.0
HFD2_k127_8321331_14 CAAX protease self-immunity K07052 - - 0.00000000000000000000000306 112.0
HFD2_k127_8321331_15 TIGRFAM Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000004292 75.0
HFD2_k127_8321331_16 nucleotidyltransferase activity - - - 0.000000001931 60.0
HFD2_k127_8321331_18 PFAM DNA polymerase beta domain protein region - - - 0.00007796 47.0
HFD2_k127_8321331_19 tail specific protease K03797 - 3.4.21.102 0.0001796 50.0
HFD2_k127_8321331_2 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005147 567.0
HFD2_k127_8321331_20 rod shape-determining protein MreD K03571 - - 0.0003158 49.0
HFD2_k127_8321331_3 oxidase, subunit K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 518.0
HFD2_k127_8321331_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 363.0
HFD2_k127_8321331_5 oxidase, subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 340.0
HFD2_k127_8321331_6 PFAM phosphoesterase RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002222 234.0
HFD2_k127_8321331_7 Protein of unknown function (DUF2723) - - - 0.000000000000000000000000000000000000000000000000000000000000003189 238.0
HFD2_k127_8321331_8 Psort location Cytoplasmic, score K19824 - - 0.000000000000000000000000000000000000000000000000000000000003969 212.0
HFD2_k127_8321331_9 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000000000000000000000000000000000001078 180.0
HFD2_k127_8321981_0 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 341.0
HFD2_k127_8321981_1 - - - - 0.00000000000000000000000000000000000000000000000000000000001239 218.0
HFD2_k127_8321981_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000005595 190.0
HFD2_k127_8321981_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000003081 184.0
HFD2_k127_8321981_4 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000004808 132.0
HFD2_k127_8338630_0 Acyl transferase domain K15314 - - 0.0 1740.0
HFD2_k127_8338630_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1204.0
HFD2_k127_8338630_10 rubredoxin - - - 0.000000000000000000000004576 103.0
HFD2_k127_8338630_11 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000168 47.0
HFD2_k127_8338630_12 Tetratricopeptide repeat - - - 0.00002735 50.0
HFD2_k127_8338630_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 387.0
HFD2_k127_8338630_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000001393 261.0
HFD2_k127_8338630_4 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000000000000000000000000000000000000000000001991 228.0
HFD2_k127_8338630_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000001524 205.0
HFD2_k127_8338630_6 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000006832 181.0
HFD2_k127_8338630_7 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000004874 148.0
HFD2_k127_8338630_8 monooxygenase activity - - - 0.00000000000000000000000000000000008571 137.0
HFD2_k127_8338630_9 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000006778 117.0
HFD2_k127_8413601_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 492.0
HFD2_k127_8413601_1 CbiX - - - 0.00000000000000000000002943 104.0
HFD2_k127_8413601_2 Calcineurin-like phosphoesterase - - - 0.0000000000005259 76.0
HFD2_k127_8428332_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 2.535e-241 752.0
HFD2_k127_8428332_1 PFAM Rh family protein ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 597.0
HFD2_k127_8428332_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000000003307 201.0
HFD2_k127_8428332_3 spermidine synthase activity - - - 0.0002559 44.0
HFD2_k127_8449625_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1391.0
HFD2_k127_8449625_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 1.119e-320 1005.0
HFD2_k127_8449625_2 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 383.0
HFD2_k127_8449625_3 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001983 254.0
HFD2_k127_8449625_4 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003766 247.0
HFD2_k127_8449625_5 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000000000000229 149.0
HFD2_k127_8449625_6 - - - - 0.00000000000000000000000000003695 135.0
HFD2_k127_8484179_0 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 363.0
HFD2_k127_8484179_1 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002718 243.0
HFD2_k127_8484179_2 Part of a membrane complex involved in electron transport K03613 - - 0.000000000000000000000000000000000000000000000000000000000000000001065 233.0
HFD2_k127_8484179_3 electron transport complex, RnfABCDGE type, B subunit K03616 - - 0.00000000000000000000000000000000000000000000000000000000001269 214.0
HFD2_k127_8484179_4 Part of a membrane complex involved in electron transport K03612 - - 0.000000000000000000000000000000003117 140.0
HFD2_k127_8496159_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 456.0
HFD2_k127_8496159_1 PFAM PSP1 C-terminal conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007677 258.0
HFD2_k127_8496159_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000001231 196.0
HFD2_k127_8496159_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000004807 61.0
HFD2_k127_850923_0 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 322.0
HFD2_k127_850923_1 Cytochrome b/b6/petB K03887 - - 0.000000000000000000000000000000000000000000000000000000000000000000001256 243.0
HFD2_k127_850923_2 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000001163 229.0
HFD2_k127_850923_3 ferrous iron binding K06990,K09141 - - 0.000000000000000000000000000000000000000000000000000000009704 216.0
HFD2_k127_850923_4 diguanylate cyclase - - - 0.00000000000000000000000000588 119.0
HFD2_k127_850923_5 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.000000000000000000000001189 109.0
HFD2_k127_8637807_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 3.861e-198 626.0
HFD2_k127_8637807_1 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 447.0
HFD2_k127_8637807_10 Rubrerythrin K19824 - - 0.000000000000000000000000000000000000904 145.0
HFD2_k127_8637807_11 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.000000000000000000000000000000000009006 148.0
HFD2_k127_8637807_12 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000006423 139.0
HFD2_k127_8637807_14 Hep Hag repeat protein - - - 0.00000001274 65.0
HFD2_k127_8637807_15 - - - - 0.00000001854 57.0
HFD2_k127_8637807_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 395.0
HFD2_k127_8637807_3 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 370.0
HFD2_k127_8637807_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 347.0
HFD2_k127_8637807_5 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006009 331.0
HFD2_k127_8637807_6 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006477 277.0
HFD2_k127_8637807_7 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000005263 230.0
HFD2_k127_8637807_8 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000001387 160.0
HFD2_k127_8637807_9 membrane K00389 - - 0.000000000000000000000000000000000000002273 158.0
HFD2_k127_871125_0 SMART Nucleotide binding protein, PINc K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 544.0
HFD2_k127_871125_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 488.0
HFD2_k127_871125_10 Alpha beta hydrolase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000003324 132.0
HFD2_k127_871125_12 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000000001118 92.0
HFD2_k127_871125_13 Protein of unknown function (DUF3467) - - - 0.00000000000000000006758 93.0
HFD2_k127_871125_15 Tetratricopeptide repeat - - - 0.00000000009383 72.0
HFD2_k127_871125_16 Protein of unknown function (DUF1018) - - - 0.000000003043 64.0
HFD2_k127_871125_17 Belongs to the HesB IscA family K15724 - - 0.000000008372 63.0
HFD2_k127_871125_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 468.0
HFD2_k127_871125_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 350.0
HFD2_k127_871125_4 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009943 343.0
HFD2_k127_871125_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 337.0
HFD2_k127_871125_6 PFAM cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007542 295.0
HFD2_k127_871125_7 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000002644 236.0
HFD2_k127_871125_8 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000001162 192.0
HFD2_k127_871125_9 thioesterase K07107 - - 0.0000000000000000000000000000000005034 140.0
HFD2_k127_8720175_0 TIGRFAM competence damage-inducible protein CinA K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000001565 263.0
HFD2_k127_8720175_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000594 245.0
HFD2_k127_8720175_10 4Fe-4S binding domain - - - 0.000004436 49.0
HFD2_k127_8720175_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000001467 237.0
HFD2_k127_8720175_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000004936 196.0
HFD2_k127_8720175_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.00000000000000000000000000000000000000000000006254 180.0
HFD2_k127_8720175_5 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000001205 132.0
HFD2_k127_8720175_6 YGGT family K02221 - - 0.000000000000000000000000000001561 123.0
HFD2_k127_8720175_7 DivIVA protein K04074 - - 0.0000000000000000000000000009153 123.0
HFD2_k127_8720175_8 Belongs to the UPF0235 family K09131 - - 0.000000000000000000000005603 103.0
HFD2_k127_8720175_9 - - - - 0.0000000000000000000005391 100.0
HFD2_k127_8746983_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 490.0
HFD2_k127_8746983_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 297.0
HFD2_k127_8746983_2 Evidence 4 Homologs of previously reported genes of - - - 0.00000005193 65.0
HFD2_k127_875152_0 Required for chromosome condensation and partitioning K03529 - - 1.926e-219 723.0
HFD2_k127_875152_1 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003595 273.0
HFD2_k127_875152_2 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000007125 155.0
HFD2_k127_875152_3 Water Stress and Hypersensitive response - - - 0.0005671 49.0
HFD2_k127_901215_0 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 384.0
HFD2_k127_901215_1 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 325.0
HFD2_k127_901215_2 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 316.0
HFD2_k127_901215_3 Domain of unknown function (DUF2520) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002694 286.0
HFD2_k127_901215_4 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009309 271.0
HFD2_k127_901215_5 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.00000000000009111 71.0
HFD2_k127_909863_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 492.0
HFD2_k127_909863_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 473.0
HFD2_k127_909863_2 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 459.0
HFD2_k127_909863_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 412.0
HFD2_k127_909863_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009072 367.0
HFD2_k127_909863_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000402 219.0
HFD2_k127_909863_6 Belongs to the SEDS family K03588 - - 0.000000000002467 70.0
HFD2_k127_914499_0 Belongs to the sulfate adenylyltransferase family K00958,K13811 - 2.7.1.25,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 606.0
HFD2_k127_914499_1 reductase beta subunit K00395 - 1.8.99.2 0.000000000000000000000003566 102.0
HFD2_k127_956947_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.573e-245 771.0
HFD2_k127_956947_1 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 475.0
HFD2_k127_956947_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007319 454.0
HFD2_k127_956947_3 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 301.0
HFD2_k127_956947_4 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000001441 185.0
HFD2_k127_961544_0 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 8.301e-223 726.0
HFD2_k127_961544_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 512.0
HFD2_k127_961544_10 cobalt ion transport K02009 - - 0.00000000000000000000000008366 111.0
HFD2_k127_961544_11 transcriptional regulator K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.0000000000000002013 85.0
HFD2_k127_961544_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 431.0
HFD2_k127_961544_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 415.0
HFD2_k127_961544_4 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001463 279.0
HFD2_k127_961544_5 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000008533 241.0
HFD2_k127_961544_6 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000001507 235.0
HFD2_k127_961544_7 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000296 137.0
HFD2_k127_961544_8 PFAM Cobalt transport protein K02008 - - 0.00000000000000000000000000000000003637 146.0
HFD2_k127_961544_9 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000008667 137.0
HFD2_k127_999313_0 PFAM asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 353.0
HFD2_k127_999313_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001184 258.0
HFD2_k127_999313_2 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.00000000000000000000000000003253 121.0