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Overview

ID MAG01653
Name HFD2_bin.45
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class JACRHJ01
Order JACRHJ01
Family JACRHJ01
Genus
Species
Assembly information
Completeness (%) 90.32
Contamination (%) 2.94
GC content (%) 60.0
N50 (bp) 17,035
Genome size (bp) 2,329,784

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2154

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1052764_0 TIGRFAM Ammonium transporter K03320 - - 5.584e-252 787.0
HFD2_k127_1052764_1 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 593.0
HFD2_k127_1052764_10 Tetrapyrrole (Corrin/Porphyrin) Methylases - - - 0.000000000000000000000000000000000000000000000000000002327 200.0
HFD2_k127_1052764_11 Predicted permease - - - 0.0000000000000000000000000000000000000000000000005253 186.0
HFD2_k127_1052764_12 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000001352 175.0
HFD2_k127_1052764_13 - K09771 - - 0.00000000000000000000000000000000000000009625 153.0
HFD2_k127_1052764_14 peptidase U32 - - - 0.0000000000000000000000000000000001391 143.0
HFD2_k127_1052764_15 Protein of unknown function (DUF1573) - - - 0.0000000000000000000001871 106.0
HFD2_k127_1052764_17 WD domain- G-beta repeat PBS lyase HEAT-like K03497 - - 0.000000000000001834 93.0
HFD2_k127_1052764_18 Protein of unknown function (DUF1573) - - - 0.00000000000005117 83.0
HFD2_k127_1052764_19 heptosyltransferase K02843 - - 0.0000000000001922 82.0
HFD2_k127_1052764_2 arsenite transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 590.0
HFD2_k127_1052764_20 alginic acid biosynthetic process - - - 0.000000005445 68.0
HFD2_k127_1052764_21 PBS lyase HEAT domain protein repeat-containing protein K22221 - - 0.00000002506 66.0
HFD2_k127_1052764_23 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000006064 66.0
HFD2_k127_1052764_3 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 525.0
HFD2_k127_1052764_4 PAS domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 453.0
HFD2_k127_1052764_5 Histidine kinase HAMP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 355.0
HFD2_k127_1052764_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 323.0
HFD2_k127_1052764_7 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 320.0
HFD2_k127_1052764_8 Peptidase family U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000008658 239.0
HFD2_k127_1052764_9 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000006674 221.0
HFD2_k127_1076047_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 4.598e-247 778.0
HFD2_k127_1076047_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 480.0
HFD2_k127_1076047_10 PFAM Carboxymuconolactone decarboxylase - - - 0.000000000000000000000000000000000000000001626 161.0
HFD2_k127_1076047_11 Methyltransferase domain - - - 0.00000000000000000000926 100.0
HFD2_k127_1076047_12 - - - - 0.000000001044 63.0
HFD2_k127_1076047_13 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K12276 - - 0.0003254 48.0
HFD2_k127_1076047_2 Sigma-54 interaction domain K02481,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 445.0
HFD2_k127_1076047_3 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 419.0
HFD2_k127_1076047_4 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 383.0
HFD2_k127_1076047_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K14080 - 2.1.1.246,4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 337.0
HFD2_k127_1076047_6 Methionine synthase, cobalamin (vitamin B12)-binding module, cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 319.0
HFD2_k127_1076047_7 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000006743 252.0
HFD2_k127_1076047_8 TIGRFAM iron-sulfur cluster binding protein - - - 0.000000000000000000000000000000000000000000000000000000001595 208.0
HFD2_k127_1076047_9 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000003367 198.0
HFD2_k127_109081_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 572.0
HFD2_k127_109081_1 amine oxidase K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 400.0
HFD2_k127_109081_2 Domain of unknown function (DUF1956) - - - 0.00000000000000000000000000000000000000000000000000000000000000003342 229.0
HFD2_k127_109081_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000137 166.0
HFD2_k127_109081_4 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000243 121.0
HFD2_k127_1098161_0 GTP-binding protein TypA K06207 - - 1.614e-235 740.0
HFD2_k127_1098161_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004979 261.0
HFD2_k127_1098161_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000005214 212.0
HFD2_k127_1098161_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000001187 169.0
HFD2_k127_1098161_4 EamA-like transporter family - - - 0.000000000000000000000000000005482 132.0
HFD2_k127_1098161_5 KR domain - - - 0.000000000000000000000000000007592 128.0
HFD2_k127_1098161_6 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000000002423 129.0
HFD2_k127_1161192_0 response regulator K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 527.0
HFD2_k127_1161192_1 PAS domain K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 527.0
HFD2_k127_1161192_10 CopG antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000002949 107.0
HFD2_k127_1161192_11 - - - - 0.000000000000000000000006671 118.0
HFD2_k127_1161192_12 - - - - 0.00000000000003421 83.0
HFD2_k127_1161192_13 structural constituent of ribosome K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000001892 65.0
HFD2_k127_1161192_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 416.0
HFD2_k127_1161192_3 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008033 377.0
HFD2_k127_1161192_4 Belongs to the acetokinase family K00929 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761 2.7.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 357.0
HFD2_k127_1161192_5 Phosphate acetyl/butaryl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000474 249.0
HFD2_k127_1161192_6 cytochrome C - - - 0.0000000000000000000000000000000000000000000000000000000000000000004231 243.0
HFD2_k127_1161192_7 serine-type endopeptidase activity K04771 - 3.4.21.107 0.0000000000000000000000000000000000163 144.0
HFD2_k127_1161192_8 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000000000004612 124.0
HFD2_k127_1161192_9 Transglycosylase associated protein - - - 0.000000000000000000000000000006397 120.0
HFD2_k127_1217464_0 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 501.0
HFD2_k127_1217464_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 301.0
HFD2_k127_1217464_2 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005191 268.0
HFD2_k127_1217464_3 Recombination protein O C terminal K03584 - - 0.00000000000000000000000001734 120.0
HFD2_k127_1231506_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 9.267e-265 824.0
HFD2_k127_1231506_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 468.0
HFD2_k127_1231506_10 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000002739 191.0
HFD2_k127_1231506_11 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000000000000000003724 160.0
HFD2_k127_1231506_12 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000001502 164.0
HFD2_k127_1231506_13 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000103 153.0
HFD2_k127_1231506_14 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000002619 145.0
HFD2_k127_1231506_15 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.00000000000000000000000000000006063 127.0
HFD2_k127_1231506_16 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000002793 119.0
HFD2_k127_1231506_17 Universal stress protein K06149 - - 0.00000000000000000000000000003375 123.0
HFD2_k127_1231506_18 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair - - - 0.0000000000000000000000003092 113.0
HFD2_k127_1231506_19 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000002529 89.0
HFD2_k127_1231506_2 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005795 467.0
HFD2_k127_1231506_20 - - - - 0.0000000000000001637 82.0
HFD2_k127_1231506_21 RNA recognition motif - - - 0.000000000007779 66.0
HFD2_k127_1231506_3 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 397.0
HFD2_k127_1231506_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008842 303.0
HFD2_k127_1231506_5 Glutamine amido-transferase K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002077 263.0
HFD2_k127_1231506_6 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006023 257.0
HFD2_k127_1231506_7 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001648 228.0
HFD2_k127_1231506_8 LexA-binding, inner membrane-associated putative hydrolase - - - 0.000000000000000000000000000000000000000000000000000006051 195.0
HFD2_k127_1231506_9 Peptidase family M23 K21471 GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000000000001603 200.0
HFD2_k127_1276101_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 580.0
HFD2_k127_1276101_1 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 478.0
HFD2_k127_1276101_10 Part of a membrane complex involved in electron transport K03614 - - 0.000003222 49.0
HFD2_k127_1276101_2 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 298.0
HFD2_k127_1276101_3 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 314.0
HFD2_k127_1276101_4 PFAM CMP dCMP deaminase zinc-binding K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001985 253.0
HFD2_k127_1276101_5 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000004057 234.0
HFD2_k127_1276101_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000002992 203.0
HFD2_k127_1276101_7 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000001119 192.0
HFD2_k127_1276101_8 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000002488 156.0
HFD2_k127_1276101_9 response regulator receiver K22010 - - 0.0000000000000000000000000005448 120.0
HFD2_k127_1290820_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 447.0
HFD2_k127_1290820_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006851 226.0
HFD2_k127_1290820_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000003298 205.0
HFD2_k127_1290820_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000006554 136.0
HFD2_k127_1358207_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.049e-277 865.0
HFD2_k127_1358207_1 Domain of unknown function (DUF1957) K16149 - 2.4.1.18 9.407e-249 777.0
HFD2_k127_1358207_10 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000001181 196.0
HFD2_k127_1358207_11 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000003606 181.0
HFD2_k127_1358207_13 HAD-hyrolase-like K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000007672 176.0
HFD2_k127_1358207_14 Domain of unknown function (DUF4912) K09942 - - 0.00000000000000000000000000000000000000000000008727 183.0
HFD2_k127_1358207_15 PFAM Capsule synthesis protein, CapA K07282 - - 0.00000000000000000000000000000000000000000003524 171.0
HFD2_k127_1358207_16 cyclic nucleotide binding K01420,K10716,K10914,K16922 - - 0.0000000000000000000000000000000000000000003313 166.0
HFD2_k127_1358207_17 YbbR-like protein - - - 0.000000000000000000000000000000003617 136.0
HFD2_k127_1358207_18 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000007456 121.0
HFD2_k127_1358207_19 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000008672 105.0
HFD2_k127_1358207_2 transporter antisigma-factor antagonist STAS K03321 - - 1.462e-227 719.0
HFD2_k127_1358207_20 - - - - 0.0000000000000000006558 88.0
HFD2_k127_1358207_21 - - - - 0.000000000002914 74.0
HFD2_k127_1358207_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 4.967e-196 620.0
HFD2_k127_1358207_4 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 332.0
HFD2_k127_1358207_5 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 305.0
HFD2_k127_1358207_6 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
HFD2_k127_1358207_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 296.0
HFD2_k127_1358207_8 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001715 259.0
HFD2_k127_1358207_9 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000001872 232.0
HFD2_k127_1376492_0 Anthranilate synthase component I K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 463.0
HFD2_k127_1376492_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000001056 241.0
HFD2_k127_1376492_2 PIN domain - - - 0.0000000000000000000000000000001617 127.0
HFD2_k127_1376492_3 SpoVT / AbrB like domain - - - 0.00000000000000007427 81.0
HFD2_k127_1408489_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1798.0
HFD2_k127_1408489_1 Aconitase family (aconitate hydratase) K01681 - 4.2.1.3 3.732e-291 905.0
HFD2_k127_1408489_10 amine dehydrogenase activity K20276 - - 0.0000000000000000001216 104.0
HFD2_k127_1408489_11 HicA toxin of bacterial toxin-antitoxin, K07339 - - 0.0000000000000000003346 90.0
HFD2_k127_1408489_12 - - - - 0.00000000001031 74.0
HFD2_k127_1408489_2 - - - - 7.723e-231 719.0
HFD2_k127_1408489_3 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 1.898e-201 637.0
HFD2_k127_1408489_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 522.0
HFD2_k127_1408489_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 501.0
HFD2_k127_1408489_6 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 327.0
HFD2_k127_1408489_7 Transcriptional regulator K18136 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000003221 259.0
HFD2_k127_1408489_8 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003744 256.0
HFD2_k127_1408489_9 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000000000001296 108.0
HFD2_k127_1631421_0 CBS domain containing protein K00974 - 2.7.7.72 1.921e-276 877.0
HFD2_k127_1631421_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 440.0
HFD2_k127_1631421_2 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 436.0
HFD2_k127_1631421_3 integrase domain protein SAM domain protein K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005433 348.0
HFD2_k127_1631421_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009673 252.0
HFD2_k127_1631421_5 hopanoid biosynthesis associated protein HpnK - - - 0.000000000000000000000000000000000000000000000000000000000003642 218.0
HFD2_k127_1631421_6 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000007536 212.0
HFD2_k127_1631421_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000001167 207.0
HFD2_k127_1631421_8 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000001302 171.0
HFD2_k127_1647831_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 564.0
HFD2_k127_1647831_1 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 486.0
HFD2_k127_1647831_10 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006501 254.0
HFD2_k127_1647831_11 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000002364 247.0
HFD2_k127_1647831_12 domain protein - - - 0.000000000000000000000000000000000000000000000000000002354 207.0
HFD2_k127_1647831_13 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000007375 190.0
HFD2_k127_1647831_14 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000000000000000002494 177.0
HFD2_k127_1647831_15 - - - - 0.0000000000000000000000000000000000000000000002986 181.0
HFD2_k127_1647831_16 ResB-like family - - - 0.000000000000000000000000000000000000000000004165 180.0
HFD2_k127_1647831_17 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.000000000000000000000000000000000000000003778 165.0
HFD2_k127_1647831_18 HEAT repeat - - - 0.00000000000000000000000000000000000213 153.0
HFD2_k127_1647831_19 Substrate binding domain of ABC-type glycine betaine transport system - - - 0.000000000000000000000000000000000002496 145.0
HFD2_k127_1647831_2 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 393.0
HFD2_k127_1647831_21 alginic acid biosynthetic process - - - 0.0000000000000000000000000000000694 138.0
HFD2_k127_1647831_22 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000002156 126.0
HFD2_k127_1647831_23 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000000001501 123.0
HFD2_k127_1647831_24 alginic acid biosynthetic process - - - 0.00000000000000000000000000001656 126.0
HFD2_k127_1647831_25 translation initiation factor activity K00694 - 2.4.1.12 0.00000000000002572 86.0
HFD2_k127_1647831_26 Tetratricopeptide repeat - - - 0.0004594 51.0
HFD2_k127_1647831_3 Arsenic resistance protein K03325 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 359.0
HFD2_k127_1647831_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006184 331.0
HFD2_k127_1647831_5 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 312.0
HFD2_k127_1647831_6 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000816 299.0
HFD2_k127_1647831_7 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 307.0
HFD2_k127_1647831_8 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001611 284.0
HFD2_k127_1647831_9 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001177 286.0
HFD2_k127_1810190_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 463.0
HFD2_k127_1810190_1 TIGRFAM cysteine K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 430.0
HFD2_k127_1810190_2 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 309.0
HFD2_k127_1810190_3 PFAM Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000006925 229.0
HFD2_k127_1810190_4 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000005316 187.0
HFD2_k127_1810190_5 DsrC like protein K11179 - - 0.00000000000000000000000000000000000000000000000001416 183.0
HFD2_k127_1810190_6 cytochrome C peroxidase - - - 0.0000000000369 70.0
HFD2_k127_1853203_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 507.0
HFD2_k127_1853203_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 505.0
HFD2_k127_1853203_2 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 377.0
HFD2_k127_1853203_3 Belongs to the aldehyde dehydrogenase family K22187 - - 0.00000000000000000000000000000000000000000000000000000000001643 213.0
HFD2_k127_1853203_4 Histidine kinase - - - 0.0000000000000000000000000001452 130.0
HFD2_k127_1857706_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1200.0
HFD2_k127_1857706_1 Biotin-protein ligase, N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001198 284.0
HFD2_k127_1857706_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000593 259.0
HFD2_k127_1857706_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000001054 233.0
HFD2_k127_1857706_4 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.000000000000000000000000000000002402 134.0
HFD2_k127_1857706_5 Domain of unknown function (DUF1736) - - - 0.0000000001238 74.0
HFD2_k127_1857706_6 transferase activity, transferring glycosyl groups - - - 0.0003186 50.0
HFD2_k127_1886533_0 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 554.0
HFD2_k127_1886533_1 oxidase, subunit K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 534.0
HFD2_k127_1886533_2 Cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 347.0
HFD2_k127_1886533_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000004862 236.0
HFD2_k127_1886533_4 PFAM phosphoesterase RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000007962 226.0
HFD2_k127_1886533_5 Psort location Cytoplasmic, score K19824 - - 0.000000000000000000000000000000000000000000000000000000000002895 212.0
HFD2_k127_1886533_6 nitric oxide reductase activity - - - 0.00000000000000000000000000000000000000000000000000007012 192.0
HFD2_k127_1886533_7 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000000000000000000000000001018 169.0
HFD2_k127_1886533_8 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000002382 117.0
HFD2_k127_1886533_9 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0004277 49.0
HFD2_k127_1894205_0 isochorismatase K06901 - - 1.667e-221 697.0
HFD2_k127_1894205_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000002458 242.0
HFD2_k127_1894205_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000001119 192.0
HFD2_k127_1894205_3 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.0000000000000000000000000000000000000004198 151.0
HFD2_k127_1894205_4 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.00000000000000000000007562 106.0
HFD2_k127_1894205_5 PD-(D/E)XK nuclease superfamily - - - 0.00000000009855 76.0
HFD2_k127_1906354_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 1.723e-234 733.0
HFD2_k127_1906354_1 Fe-S oxidoreductase K11473 - - 0.0000000000000000000000000000000000002396 149.0
HFD2_k127_1964977_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 8.483e-282 886.0
HFD2_k127_1964977_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 587.0
HFD2_k127_1964977_10 Binding-protein-dependent transport system inner membrane component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000007717 231.0
HFD2_k127_1964977_11 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000004781 214.0
HFD2_k127_1964977_12 phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000001486 157.0
HFD2_k127_1964977_13 Lysin motif - - - 0.00000000000000000000000000000002111 140.0
HFD2_k127_1964977_14 - - - - 0.00000000000000005435 86.0
HFD2_k127_1964977_15 Phosphate-selective porin O and P - - - 0.00000000000000008308 94.0
HFD2_k127_1964977_16 Outer membrane lipoprotein - - - 0.000000000000006059 85.0
HFD2_k127_1964977_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.0000000000007908 73.0
HFD2_k127_1964977_19 Belongs to the Smg family K03747 - - 0.00009892 51.0
HFD2_k127_1964977_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 523.0
HFD2_k127_1964977_3 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 377.0
HFD2_k127_1964977_4 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 348.0
HFD2_k127_1964977_5 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 298.0
HFD2_k127_1964977_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 297.0
HFD2_k127_1964977_7 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000007634 252.0
HFD2_k127_1964977_8 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001521 251.0
HFD2_k127_1964977_9 Proteasome subunit K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000433 245.0
HFD2_k127_1989933_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.199e-307 960.0
HFD2_k127_1989933_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.078e-205 648.0
HFD2_k127_1989933_10 COG1283 Na phosphate symporter K03324 - - 0.00000000002421 65.0
HFD2_k127_1989933_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 9.036e-195 615.0
HFD2_k127_1989933_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 597.0
HFD2_k127_1989933_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 333.0
HFD2_k127_1989933_5 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 301.0
HFD2_k127_1989933_6 PFAM MscS Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001234 260.0
HFD2_k127_1989933_7 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000002049 221.0
HFD2_k127_1989933_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000597 121.0
HFD2_k127_1989933_9 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000007797 108.0
HFD2_k127_1998220_0 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 366.0
HFD2_k127_1998220_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 361.0
HFD2_k127_1998220_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 321.0
HFD2_k127_1998220_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000157 225.0
HFD2_k127_1998220_4 Tryptophanyl-tRNA synthetase K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.0000000000000000000000000000000000000000000000000009065 202.0
HFD2_k127_206178_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 582.0
HFD2_k127_206178_1 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004171 515.0
HFD2_k127_206178_10 Lysin motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008203 250.0
HFD2_k127_206178_11 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000003094 213.0
HFD2_k127_206178_12 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.000000000000000000000000000000000000000000000000000000006304 208.0
HFD2_k127_206178_13 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000004728 198.0
HFD2_k127_206178_14 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000003707 190.0
HFD2_k127_206178_15 Belongs to the SUA5 family K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000003787 173.0
HFD2_k127_206178_16 TPM domain K06872 - - 0.000000000000000000000000000000000000000005905 165.0
HFD2_k127_206178_17 nucleotidyltransferase activity - - - 0.000000000000000000000000000000000000003708 155.0
HFD2_k127_206178_18 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000001837 150.0
HFD2_k127_206178_19 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000001756 128.0
HFD2_k127_206178_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 477.0
HFD2_k127_206178_20 Protein tyrosine kinase - - - 0.000000000000000000009564 102.0
HFD2_k127_206178_21 Late competence development protein ComFB K02241 - - 0.00000005093 59.0
HFD2_k127_206178_3 TIGRFAM cytochrome C family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004408 480.0
HFD2_k127_206178_4 N-4 methylation of cytosine K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 367.0
HFD2_k127_206178_5 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 323.0
HFD2_k127_206178_6 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008209 309.0
HFD2_k127_206178_7 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 312.0
HFD2_k127_206178_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 - 3.1.11.2,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 302.0
HFD2_k127_206178_9 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 300.0
HFD2_k127_208563_0 Belongs to the carbamoyltransferase HypF family K04656 - - 6.052e-228 736.0
HFD2_k127_208563_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 478.0
HFD2_k127_208563_2 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 294.0
HFD2_k127_208563_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000003489 166.0
HFD2_k127_208563_4 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000001315 69.0
HFD2_k127_2099041_0 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 431.0
HFD2_k127_2099041_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 377.0
HFD2_k127_2099041_2 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000002645 212.0
HFD2_k127_2099041_3 Belongs to the Fur family K09825 - - 0.00000000000000000000000000000000000000000000001343 174.0
HFD2_k127_2099041_4 transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000000001964 151.0
HFD2_k127_2099041_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000145 54.0
HFD2_k127_2099041_6 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0006156 49.0
HFD2_k127_2114948_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 537.0
HFD2_k127_2114948_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 479.0
HFD2_k127_2114948_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000007523 181.0
HFD2_k127_2114948_11 monooxygenase activity - - - 0.000000000000000000000000000000000002865 142.0
HFD2_k127_2114948_12 TIGRFAM ribonuclease BN K07058 - - 0.000000000000004842 85.0
HFD2_k127_2114948_13 - - - - 0.000000000003366 69.0
HFD2_k127_2114948_14 NosL - - - 0.00000000004906 69.0
HFD2_k127_2114948_2 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 317.0
HFD2_k127_2114948_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000006171 263.0
HFD2_k127_2114948_4 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000001431 278.0
HFD2_k127_2114948_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006723 255.0
HFD2_k127_2114948_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000007578 246.0
HFD2_k127_2114948_7 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003298 259.0
HFD2_k127_2114948_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000009716 236.0
HFD2_k127_2114948_9 PFAM Bacterial regulatory proteins, tetR family K16137 - - 0.00000000000000000000000000000000000000000000004596 175.0
HFD2_k127_214330_0 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006532 246.0
HFD2_k127_214330_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000007592 201.0
HFD2_k127_214330_2 B12 binding domain - - - 0.00000000000000000000000000000000000000000217 166.0
HFD2_k127_214330_3 PFAM Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000001076 117.0
HFD2_k127_214330_4 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000007913 110.0
HFD2_k127_214330_5 Methyltransferase domain - - - 0.0000000000000000000001139 112.0
HFD2_k127_214330_6 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000001497 53.0
HFD2_k127_2177696_0 Aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008641 613.0
HFD2_k127_2177696_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 555.0
HFD2_k127_2177696_2 PFAM peptidase S8 and S53 subtilisin kexin sedolisin K08651 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 375.0
HFD2_k127_2177696_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 299.0
HFD2_k127_2177696_4 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 291.0
HFD2_k127_2177696_5 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001949 288.0
HFD2_k127_2177696_6 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000002207 183.0
HFD2_k127_2177696_7 Major facilitator Superfamily K06902 - - 0.000000000000000007805 91.0
HFD2_k127_2177696_8 - - - - 0.000000000000001017 84.0
HFD2_k127_2177827_0 SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 K00239 - 1.3.5.1,1.3.5.4 8.669e-264 822.0
HFD2_k127_2177827_1 Cache domain - - - 3.593e-251 789.0
HFD2_k127_2177827_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 392.0
HFD2_k127_2177827_3 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000574 325.0
HFD2_k127_2177827_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000003207 220.0
HFD2_k127_2177827_5 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.00000000000000000000000000000000000000000001721 169.0
HFD2_k127_2177827_6 COG0784 FOG CheY-like receiver - - - 0.0000000000000000000000000000000000000001024 168.0
HFD2_k127_2177827_7 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000002618 103.0
HFD2_k127_2177827_8 Cation efflux family - - - 0.0000001897 53.0
HFD2_k127_2181843_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 438.0
HFD2_k127_2181843_1 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002993 259.0
HFD2_k127_2181843_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000001674 139.0
HFD2_k127_2181843_3 - - - - 0.0000008644 58.0
HFD2_k127_2184645_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1036.0
HFD2_k127_2184645_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 481.0
HFD2_k127_2184645_10 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000001734 238.0
HFD2_k127_2184645_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000002758 235.0
HFD2_k127_2184645_12 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000000001175 235.0
HFD2_k127_2184645_13 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000008991 218.0
HFD2_k127_2184645_14 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000003522 173.0
HFD2_k127_2184645_15 MobA-like NTP transferase domain K03752 - 2.7.7.77 0.0000000000000000000000000000000001842 139.0
HFD2_k127_2184645_16 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000009817 96.0
HFD2_k127_2184645_17 protein secretion K03116 - - 0.00000000003018 65.0
HFD2_k127_2184645_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000826 479.0
HFD2_k127_2184645_3 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007416 473.0
HFD2_k127_2184645_4 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 337.0
HFD2_k127_2184645_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 340.0
HFD2_k127_2184645_6 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 315.0
HFD2_k127_2184645_7 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 296.0
HFD2_k127_2184645_8 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 285.0
HFD2_k127_2184645_9 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000998 288.0
HFD2_k127_2197314_0 UvrD REP helicase K03657,K16898 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000006246 226.0
HFD2_k127_2321485_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 3.135e-242 766.0
HFD2_k127_2321485_1 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 543.0
HFD2_k127_2321485_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 409.0
HFD2_k127_2321485_3 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000003962 203.0
HFD2_k127_2321485_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000005728 192.0
HFD2_k127_2321485_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000001469 180.0
HFD2_k127_2321485_6 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000004276 61.0
HFD2_k127_2321485_7 Phosphorylase superfamily K01243 - 3.2.2.9 0.000000007762 66.0
HFD2_k127_2321485_8 peroxiredoxin activity K01607 - 4.1.1.44 0.0000008623 56.0
HFD2_k127_2330910_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 410.0
HFD2_k127_2330910_1 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 307.0
HFD2_k127_2330910_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000001703 118.0
HFD2_k127_2330910_3 ATP synthase B/B' CF(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000001669 99.0
HFD2_k127_2330910_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000005399 74.0
HFD2_k127_237016_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 9.789e-222 697.0
HFD2_k127_237016_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 432.0
HFD2_k127_237016_2 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.00000000000000000000326 96.0
HFD2_k127_239473_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 509.0
HFD2_k127_239473_1 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 354.0
HFD2_k127_239473_2 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001594 250.0
HFD2_k127_239473_3 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000005061 166.0
HFD2_k127_2444036_0 B12 binding domain K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 385.0
HFD2_k127_2444036_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001258 289.0
HFD2_k127_2444036_10 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000002035 90.0
HFD2_k127_2444036_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000002435 251.0
HFD2_k127_2444036_3 Fibronectin-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005516 261.0
HFD2_k127_2444036_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000002489 208.0
HFD2_k127_2444036_5 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000001058 204.0
HFD2_k127_2444036_6 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000002682 203.0
HFD2_k127_2444036_7 Ribosomal protein S9/S16 K02996 - - 0.00000000000000000000000000000000000000000000000193 176.0
HFD2_k127_2444036_8 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000004418 95.0
HFD2_k127_2444036_9 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000006541 92.0
HFD2_k127_2463780_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 3.184e-281 888.0
HFD2_k127_2463780_1 metal-dependent hydrolase with the TIM-barrel fold - - - 1.949e-277 865.0
HFD2_k127_2463780_10 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005001 254.0
HFD2_k127_2463780_11 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000339 232.0
HFD2_k127_2463780_12 - K09932 - - 0.0000000000000000000000000000000000000001604 156.0
HFD2_k127_2463780_13 histidine kinase - - - 0.000000000000000000000007408 115.0
HFD2_k127_2463780_14 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000005945 99.0
HFD2_k127_2463780_15 PFAM Cyclic nucleotide-binding domain - - - 0.00000000000000003062 87.0
HFD2_k127_2463780_16 Transcriptional regulator PadR-like family - - - 0.0000000000001206 78.0
HFD2_k127_2463780_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.063e-209 671.0
HFD2_k127_2463780_3 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 541.0
HFD2_k127_2463780_4 Nickel-dependent hydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 482.0
HFD2_k127_2463780_5 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 453.0
HFD2_k127_2463780_6 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 310.0
HFD2_k127_2463780_7 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 302.0
HFD2_k127_2463780_8 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005626 275.0
HFD2_k127_2463780_9 peptidase U32 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004116 278.0
HFD2_k127_255699_0 Surface antigen K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 603.0
HFD2_k127_255699_1 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 563.0
HFD2_k127_255699_10 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000001714 192.0
HFD2_k127_255699_11 TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000000001008 193.0
HFD2_k127_255699_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000001616 179.0
HFD2_k127_255699_13 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000001596 178.0
HFD2_k127_255699_14 Outer membrane protein (OmpH-like) K06142 - - 0.000000000000000002895 91.0
HFD2_k127_255699_15 Domain of unknown function (DUF4410) - - - 0.00000000000000002236 89.0
HFD2_k127_255699_2 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 439.0
HFD2_k127_255699_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 381.0
HFD2_k127_255699_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 350.0
HFD2_k127_255699_5 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 327.0
HFD2_k127_255699_6 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 306.0
HFD2_k127_255699_7 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009154 303.0
HFD2_k127_255699_8 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001237 292.0
HFD2_k127_255699_9 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003817 249.0
HFD2_k127_2600444_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 476.0
HFD2_k127_2600444_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000002634 192.0
HFD2_k127_2692936_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 520.0
HFD2_k127_2692936_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 360.0
HFD2_k127_2692936_10 PFAM NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000005965 194.0
HFD2_k127_2692936_11 Polypeptide deformylase K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000002737 186.0
HFD2_k127_2692936_12 HAD-hyrolase-like K07025 - - 0.000000000000000000000000000000000000000000000000007624 188.0
HFD2_k127_2692936_13 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000001807 188.0
HFD2_k127_2692936_14 SAM-dependent RNA methyltransferase - - - 0.000000000000000000000000000000000000000000000006969 188.0
HFD2_k127_2692936_15 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000008392 148.0
HFD2_k127_2692936_16 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000000000194 121.0
HFD2_k127_2692936_17 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000001885 120.0
HFD2_k127_2692936_18 ribosome binding K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000005948 123.0
HFD2_k127_2692936_19 denitrification pathway K00380 - 1.8.1.2 0.0000000000000000000006142 112.0
HFD2_k127_2692936_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 334.0
HFD2_k127_2692936_20 COG0607 Rhodanese-related sulfurtransferase K03406,K21028 - 2.8.1.11 0.000000000000000000001118 98.0
HFD2_k127_2692936_21 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000001107 96.0
HFD2_k127_2692936_22 Domain of unknown function (DUF4082) - - - 0.0000000000001578 83.0
HFD2_k127_2692936_23 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000001485 74.0
HFD2_k127_2692936_24 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000001708 70.0
HFD2_k127_2692936_25 NHL repeat containing protein - - - 0.000000004207 69.0
HFD2_k127_2692936_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 295.0
HFD2_k127_2692936_4 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 286.0
HFD2_k127_2692936_5 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000639 282.0
HFD2_k127_2692936_6 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000004358 241.0
HFD2_k127_2692936_7 Methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000000001468 229.0
HFD2_k127_2692936_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000001042 223.0
HFD2_k127_2692936_9 Protein of unknown function (DUF2723) - - - 0.0000000000000000000000000000000000000000000000000000000002692 226.0
HFD2_k127_2710759_0 Molybdopterin oxidoreductase Fe4S4 domain K00123,K05299 - 1.17.1.10,1.17.1.9 9.767e-283 894.0
HFD2_k127_2710759_1 Pyridine nucleotide-disulphide oxidoreductase K15022 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.17.1.10 9.905e-234 738.0
HFD2_k127_2710759_10 TIGRFAM cysteine K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 430.0
HFD2_k127_2710759_11 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 427.0
HFD2_k127_2710759_12 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 425.0
HFD2_k127_2710759_13 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 422.0
HFD2_k127_2710759_14 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528,K16951 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 337.0
HFD2_k127_2710759_16 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004614 329.0
HFD2_k127_2710759_17 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 293.0
HFD2_k127_2710759_18 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001226 297.0
HFD2_k127_2710759_19 MltA specific insert domain K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
HFD2_k127_2710759_2 4Fe-4S dicluster domain - - - 4.415e-222 698.0
HFD2_k127_2710759_20 Evidence 4 Homologs of previously reported genes of K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004539 267.0
HFD2_k127_2710759_21 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000005103 249.0
HFD2_k127_2710759_22 Tetrapyrrole (Corrin/Porphyrin) Methylases K01719,K01749,K02303,K13542,K13543 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000005313 246.0
HFD2_k127_2710759_23 Nitrate reductase gamma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000001595 234.0
HFD2_k127_2710759_24 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001188 229.0
HFD2_k127_2710759_25 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000001484 229.0
HFD2_k127_2710759_26 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.000000000000000000000000000000000000000000000000000000000000003033 231.0
HFD2_k127_2710759_27 MOSC domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000547 214.0
HFD2_k127_2710759_28 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000005922 212.0
HFD2_k127_2710759_29 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000002206 198.0
HFD2_k127_2710759_3 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 610.0
HFD2_k127_2710759_30 molybdenum cofactor - - - 0.00000000000000000000000000000000000000000000000000002073 199.0
HFD2_k127_2710759_31 DsrC like protein K11179 - - 0.00000000000000000000000000000000000000000000000003041 181.0
HFD2_k127_2710759_32 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000002108 183.0
HFD2_k127_2710759_33 DsrE/DsrF-like family K07235 - - 0.000000000000000000000000000000000000000000000006435 174.0
HFD2_k127_2710759_34 COG2199 FOG GGDEF domain - - - 0.0000000000000000000000000000000000000000003504 178.0
HFD2_k127_2710759_35 PFAM DsrE family protein K07236 - - 0.000000000000000000000000000000000000007289 147.0
HFD2_k127_2710759_36 COG2143 Thioredoxin-related protein - - - 0.000000000000000000000000000000000002208 143.0
HFD2_k127_2710759_37 lyase activity - - - 0.000000000000000000000000000000000009865 144.0
HFD2_k127_2710759_38 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.0000000000000000000000000000000001543 136.0
HFD2_k127_2710759_39 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000002127 148.0
HFD2_k127_2710759_4 TIGRFAM sulfite reductase, dissimilatory-type alpha subunit K11180 - 1.8.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 586.0
HFD2_k127_2710759_40 part of a sulfur-relay system K11179 - - 0.0000000000000000000000000002063 117.0
HFD2_k127_2710759_41 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000002248 116.0
HFD2_k127_2710759_42 PFAM DsrH family protein K07237 - - 0.0000000000000000000000005367 107.0
HFD2_k127_2710759_43 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000006456 111.0
HFD2_k127_2710759_44 redox protein regulator of disulfide bond formation K07397 - - 0.00000000000000000000001979 105.0
HFD2_k127_2710759_45 COG2143 Thioredoxin-related protein - - - 0.0000000000000000000000245 107.0
HFD2_k127_2710759_46 - - - - 0.00000000000000000008078 97.0
HFD2_k127_2710759_47 COG2143 Thioredoxin-related protein - - - 0.00000000000000005374 87.0
HFD2_k127_2710759_48 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000916 83.0
HFD2_k127_2710759_49 Copper resistance protein CopZ K07213 - - 0.000000000000004688 77.0
HFD2_k127_2710759_5 TIGRFAM sulfite reductase, dissimilatory-type beta subunit K11181 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 523.0
HFD2_k127_2710759_50 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000008969 81.0
HFD2_k127_2710759_51 cytochrome C peroxidase - - - 0.00000000000004383 79.0
HFD2_k127_2710759_52 Rubrerythrin - - - 0.00000000002552 70.0
HFD2_k127_2710759_53 monooxygenase activity K06966 - 3.2.2.10 0.0000000007614 65.0
HFD2_k127_2710759_54 - - - - 0.00000000721 66.0
HFD2_k127_2710759_6 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009086 520.0
HFD2_k127_2710759_7 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 511.0
HFD2_k127_2710759_8 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 473.0
HFD2_k127_2710759_9 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 447.0
HFD2_k127_2715857_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 482.0
HFD2_k127_2715857_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 430.0
HFD2_k127_2715857_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 360.0
HFD2_k127_2715857_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 365.0
HFD2_k127_2715857_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 326.0
HFD2_k127_2715857_5 pyridoxamine 5'-phosphate oxidase-related, FMN-binding - - - 0.0000000000000000000000000001784 119.0
HFD2_k127_2715857_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000001115 100.0
HFD2_k127_2715857_7 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000001162 68.0
HFD2_k127_2715857_8 ribonuclease P activity K03536,K08998 GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.00000004274 61.0
HFD2_k127_2759263_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.086e-266 837.0
HFD2_k127_2759263_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 3.905e-212 680.0
HFD2_k127_2759263_10 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000002662 68.0
HFD2_k127_2759263_11 Autoinducer synthase - - - 0.00000000003 73.0
HFD2_k127_2759263_12 - - - - 0.00003024 47.0
HFD2_k127_2759263_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008123 549.0
HFD2_k127_2759263_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 553.0
HFD2_k127_2759263_4 TIGRFAM single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 477.0
HFD2_k127_2759263_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074,K12257 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 343.0
HFD2_k127_2759263_6 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000002317 205.0
HFD2_k127_2759263_7 Autoinducer binding domain K20334 - - 0.00000000000000000000000000000000000000000000000000001136 197.0
HFD2_k127_2759263_8 Endoribonuclease L-PSP K09022 GO:0003674,GO:0003824,GO:0016787,GO:0019239 3.5.99.10 0.0000000000000000000000000000000000000000000000001691 179.0
HFD2_k127_2759263_9 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000000000000000000006979 124.0
HFD2_k127_2793952_0 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006351 506.0
HFD2_k127_2793952_1 phosphate ion binding K02040 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 400.0
HFD2_k127_2793952_10 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000005448 126.0
HFD2_k127_2793952_11 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000002759 92.0
HFD2_k127_2793952_2 His Kinase A (phosphoacceptor) domain K02484,K07636,K07768 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 398.0
HFD2_k127_2793952_3 PHP domain protein K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 361.0
HFD2_k127_2793952_4 transferase activity, transferring glycosyl groups K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 366.0
HFD2_k127_2793952_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 347.0
HFD2_k127_2793952_6 inorganic phosphate transmembrane transporter activity K02037,K02038 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 313.0
HFD2_k127_2793952_7 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008104 288.0
HFD2_k127_2793952_8 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005385 267.0
HFD2_k127_2793952_9 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000001972 138.0
HFD2_k127_2835336_0 CobB/CobQ-like glutamine amidotransferase domain K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 512.0
HFD2_k127_2835336_1 Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L- methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by K22466 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 435.0
HFD2_k127_2835336_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005907 408.0
HFD2_k127_2835336_3 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 337.0
HFD2_k127_2835336_4 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 311.0
HFD2_k127_2835336_5 CoA-binding domain K13012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009221 277.0
HFD2_k127_2835336_6 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001955 261.0
HFD2_k127_2835336_7 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000001297 189.0
HFD2_k127_2835336_8 - K02009 - - 0.00000000000000000002221 101.0
HFD2_k127_2865285_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 599.0
HFD2_k127_2865285_1 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 589.0
HFD2_k127_2865285_10 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 329.0
HFD2_k127_2865285_11 Chain length determinant protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002856 281.0
HFD2_k127_2865285_12 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000823 243.0
HFD2_k127_2865285_13 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000001396 225.0
HFD2_k127_2865285_14 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000641 219.0
HFD2_k127_2865285_15 AAA domain K08252 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000009956 209.0
HFD2_k127_2865285_16 PFAM Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000001508 200.0
HFD2_k127_2865285_17 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000009168 182.0
HFD2_k127_2865285_18 Transcription termination factor nusG - - - 0.0000000000000000000000000000000000000000000105 168.0
HFD2_k127_2865285_19 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000006581 158.0
HFD2_k127_2865285_2 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 549.0
HFD2_k127_2865285_20 PEP-CTERM motif - - - 0.00000000000000000000000000000000000001235 153.0
HFD2_k127_2865285_21 Fibronectin type 3 domain - - - 0.000000000000000000000000000002108 141.0
HFD2_k127_2865285_22 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000002267 120.0
HFD2_k127_2865285_23 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000001609 121.0
HFD2_k127_2865285_24 - - - - 0.0000000000000000000005154 110.0
HFD2_k127_2865285_25 Domain of unknown function (DUF4082) - - - 0.0000000000002252 85.0
HFD2_k127_2865285_26 Mo-co oxidoreductase dimerisation domain - - - 0.0000003775 64.0
HFD2_k127_2865285_27 Bacterial Ig-like domain - - - 0.00000342 61.0
HFD2_k127_2865285_28 - - - - 0.00008313 52.0
HFD2_k127_2865285_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 565.0
HFD2_k127_2865285_4 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000878 461.0
HFD2_k127_2865285_5 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 438.0
HFD2_k127_2865285_6 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 427.0
HFD2_k127_2865285_7 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 402.0
HFD2_k127_2865285_8 Undecaprenyl-phosphate galactose phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 366.0
HFD2_k127_2865285_9 AAA domain K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 335.0
HFD2_k127_2918512_0 AcrB/AcrD/AcrF family K03296,K19594 - - 3.14e-222 697.0
HFD2_k127_2918512_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 551.0
HFD2_k127_2918512_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 523.0
HFD2_k127_2959_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 612.0
HFD2_k127_2959_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 430.0
HFD2_k127_2959_10 - - - - 0.000000000000000000000000007481 121.0
HFD2_k127_2959_11 Bacterial lipid A biosynthesis acyltransferase - - - 0.00000000000000000000000002014 119.0
HFD2_k127_2959_13 Belongs to the glycosyl hydrolase 18 family - - - 0.00002835 50.0
HFD2_k127_2959_2 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 406.0
HFD2_k127_2959_3 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 372.0
HFD2_k127_2959_4 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000001008 246.0
HFD2_k127_2959_5 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000001195 158.0
HFD2_k127_2959_6 membrane K00389 - - 0.0000000000000000000000000000000000001623 154.0
HFD2_k127_2959_7 Rubrerythrin K19824 - - 0.000000000000000000000000000000000000462 146.0
HFD2_k127_2959_8 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000001789 153.0
HFD2_k127_2959_9 - - - - 0.000000000000000000000000002218 115.0
HFD2_k127_2979762_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 2.673e-284 899.0
HFD2_k127_2979762_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 344.0
HFD2_k127_2979762_2 Flavoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 339.0
HFD2_k127_2979762_3 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000003389 258.0
HFD2_k127_2979762_4 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000008102 203.0
HFD2_k127_2979762_5 Histidine kinase - - - 0.00000000000000000000000000000000000001072 156.0
HFD2_k127_2979762_6 12 heme-binding sites - - - 0.0000000000000000000000000000002911 128.0
HFD2_k127_2979762_7 methyltransferase activity - - - 0.0000000000000000003601 96.0
HFD2_k127_3012384_0 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 1.283e-207 661.0
HFD2_k127_3012384_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 572.0
HFD2_k127_3012384_10 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 293.0
HFD2_k127_3012384_11 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009034 277.0
HFD2_k127_3012384_12 protein secretion K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001126 306.0
HFD2_k127_3012384_13 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000003451 249.0
HFD2_k127_3012384_14 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000002535 219.0
HFD2_k127_3012384_15 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000003435 208.0
HFD2_k127_3012384_16 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000005464 159.0
HFD2_k127_3012384_17 PFAM Uncharacterised P-loop hydrolase UPF0079 K06925 - - 0.000000000000000000000000000000000000001187 165.0
HFD2_k127_3012384_18 Protein of unknown function (DUF1571) - - - 0.0000000000000000000000000000000000002468 150.0
HFD2_k127_3012384_19 Domain of unknown function (DUF1844) - - - 0.0000000000000001102 83.0
HFD2_k127_3012384_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 476.0
HFD2_k127_3012384_20 - - GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - 0.0000000000000001272 81.0
HFD2_k127_3012384_21 MutS domain I K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000001061 77.0
HFD2_k127_3012384_22 protein transport across the cell outer membrane K02246,K08084 - - 0.00000001629 64.0
HFD2_k127_3012384_23 Bacterial Ig-like domain - - - 0.00000003857 68.0
HFD2_k127_3012384_24 peptidylprolyl isomerase K03771 - 5.2.1.8 0.0000001027 61.0
HFD2_k127_3012384_25 Fibronectin type III domain protein - - - 0.00008468 57.0
HFD2_k127_3012384_3 Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 441.0
HFD2_k127_3012384_4 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 427.0
HFD2_k127_3012384_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 344.0
HFD2_k127_3012384_6 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 374.0
HFD2_k127_3012384_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 338.0
HFD2_k127_3012384_8 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 322.0
HFD2_k127_3012384_9 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 312.0
HFD2_k127_301334_0 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 563.0
HFD2_k127_301334_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 544.0
HFD2_k127_301334_10 Glycosyl transferase family 2 K12992 - - 0.00000000000000000000000000000000000000000000000000000002625 210.0
HFD2_k127_301334_11 - K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000001788 210.0
HFD2_k127_301334_12 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000004186 194.0
HFD2_k127_301334_13 Transport permease protein K09690 - - 0.000000000000000000000000000000000000000000000000002211 194.0
HFD2_k127_301334_14 PFAM Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000003841 186.0
HFD2_k127_301334_15 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000000000000000000000002273 165.0
HFD2_k127_301334_16 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.000000000000000000000000000000000000001232 149.0
HFD2_k127_301334_17 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000001049 163.0
HFD2_k127_301334_18 PFAM glycosyl transferase family 9 K02843 - - 0.00000000000000000000000000000003427 142.0
HFD2_k127_301334_19 HlyD family secretion protein - - - 0.00000000000009496 72.0
HFD2_k127_301334_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 537.0
HFD2_k127_301334_20 Domain of unknown function (DUF378) K09779 - - 0.000000000007308 68.0
HFD2_k127_301334_3 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 335.0
HFD2_k127_301334_4 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 325.0
HFD2_k127_301334_5 Histidine kinase K20974 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000003288 276.0
HFD2_k127_301334_6 Glycosyl transferase, family 2 K00721,K07011,K13005,K20444 - 2.4.1.60,2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000001533 269.0
HFD2_k127_301334_7 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001243 246.0
HFD2_k127_301334_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000006862 219.0
HFD2_k127_301334_9 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000001195 213.0
HFD2_k127_3037537_0 Amino acid permease - - - 9.789e-245 773.0
HFD2_k127_3037537_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 6.967e-240 757.0
HFD2_k127_3037537_10 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000009981 151.0
HFD2_k127_3037537_11 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 0.0000000000000000000000000000003197 123.0
HFD2_k127_3037537_12 Protein of unknown function, DUF485 - - - 0.00000000000000000000000000001438 120.0
HFD2_k127_3037537_13 - - - - 0.0002231 46.0
HFD2_k127_3037537_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 602.0
HFD2_k127_3037537_3 lysine 2,3-aminomutase activity K01843,K19810 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008943 572.0
HFD2_k127_3037537_4 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 445.0
HFD2_k127_3037537_5 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 438.0
HFD2_k127_3037537_6 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 323.0
HFD2_k127_3037537_7 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 292.0
HFD2_k127_3037537_8 acetyltransferase K18815 - 2.3.1.82 0.000000000000000000000000000000000000000000000000001172 187.0
HFD2_k127_3037537_9 self proteolysis - - - 0.0000000000000000000000000000000000000000000002106 183.0
HFD2_k127_3060651_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 533.0
HFD2_k127_3060651_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008646 248.0
HFD2_k127_3060651_2 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000000000000000000000000005648 136.0
HFD2_k127_3089120_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1107.0
HFD2_k127_3089120_1 PFAM magnesium chelatase ChlI subunit K07391 - - 1.595e-205 658.0
HFD2_k127_3089120_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 362.0
HFD2_k127_3089120_11 Methylenetetrahydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 342.0
HFD2_k127_3089120_12 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 354.0
HFD2_k127_3089120_13 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 334.0
HFD2_k127_3089120_14 regulatory protein IclR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004797 307.0
HFD2_k127_3089120_15 PFAM CobQ CobB MinD ParA nucleotide binding domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 299.0
HFD2_k127_3089120_16 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 299.0
HFD2_k127_3089120_17 histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009009 288.0
HFD2_k127_3089120_18 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003823 260.0
HFD2_k127_3089120_19 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000002921 245.0
HFD2_k127_3089120_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 4.308e-204 647.0
HFD2_k127_3089120_20 electron transfer activity K03615 - - 0.0000000000000000000000000000000000000000000000000000000000000000004928 236.0
HFD2_k127_3089120_21 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000003247 234.0
HFD2_k127_3089120_22 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000568 229.0
HFD2_k127_3089120_23 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000006433 226.0
HFD2_k127_3089120_24 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000001027 221.0
HFD2_k127_3089120_25 LysE type translocator - - - 0.00000000000000000000000000000000000000000000000000006194 193.0
HFD2_k127_3089120_26 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000001214 179.0
HFD2_k127_3089120_27 Metal-dependent hydrolase K07043 - - 0.0000000000000000000000000000000000000000000007517 175.0
HFD2_k127_3089120_28 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000001842 174.0
HFD2_k127_3089120_29 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000664 173.0
HFD2_k127_3089120_3 PFAM CHASE2 domain - - - 4.788e-200 637.0
HFD2_k127_3089120_30 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000003408 161.0
HFD2_k127_3089120_31 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000006651 139.0
HFD2_k127_3089120_32 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000003342 133.0
HFD2_k127_3089120_33 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000007229 128.0
HFD2_k127_3089120_34 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000004622 126.0
HFD2_k127_3089120_37 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000000001787 110.0
HFD2_k127_3089120_38 TIGRFAM SagB-type dehydrogenase - - - 0.0000000000000003844 78.0
HFD2_k127_3089120_39 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00176 - 1.2.7.3 0.0000000000000004903 80.0
HFD2_k127_3089120_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 519.0
HFD2_k127_3089120_40 Domain of unknown function (DUF4082) - - - 0.000000000000002306 91.0
HFD2_k127_3089120_41 histone H2A K63-linked ubiquitination - - - 0.00000117 59.0
HFD2_k127_3089120_42 cell adhesion involved in biofilm formation - - - 0.00001496 58.0
HFD2_k127_3089120_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 450.0
HFD2_k127_3089120_6 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 435.0
HFD2_k127_3089120_7 RecF/RecN/SMC N terminal domain K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 414.0
HFD2_k127_3089120_8 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 386.0
HFD2_k127_3089120_9 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 402.0
HFD2_k127_3288626_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 9.601e-296 925.0
HFD2_k127_3288626_1 Conserved hypothetical protein 698 - - - 3.816e-211 665.0
HFD2_k127_3288626_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000001492 145.0
HFD2_k127_3288626_3 Domain of unknown function DUF302 - - - 0.0000000000001432 78.0
HFD2_k127_3288626_4 - - - - 0.000000000004622 69.0
HFD2_k127_350529_0 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 482.0
HFD2_k127_350529_1 Isochorismatase family K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000001667 199.0
HFD2_k127_350529_2 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000004968 181.0
HFD2_k127_350529_3 Protein of unknown function (DUF1318) - - - 0.000000000000000000000000000000000000003941 154.0
HFD2_k127_3506951_0 response to heat K03696 - - 2.203e-306 958.0
HFD2_k127_3506951_1 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008715 255.0
HFD2_k127_3506951_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002136 247.0
HFD2_k127_3506951_3 Lipoate--protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000006044 235.0
HFD2_k127_3506951_4 Domain of unknown function (DUF370) K09777 - - 0.0000000000000000000000004479 107.0
HFD2_k127_3506951_5 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.00000000000000000000007225 104.0
HFD2_k127_3513076_0 nucleic acid binding OB-fold tRNA helicase-type K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001735 288.0
HFD2_k127_3513076_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000003637 137.0
HFD2_k127_3513076_2 Sulfotransferase domain - - - 0.000000000000000000000007473 111.0
HFD2_k127_3513076_3 Sulfotransferase domain - - - 0.00000000000000004906 91.0
HFD2_k127_3513076_4 PFAM glutamate synthase alpha subunit - - - 0.0000000000000003546 79.0
HFD2_k127_3513076_5 Pfam:UPF0118 - - - 0.00000000001198 75.0
HFD2_k127_3513076_6 Belongs to the GbsR family K22109 - - 0.000006036 55.0
HFD2_k127_3541739_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 558.0
HFD2_k127_3541739_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 456.0
HFD2_k127_3541739_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 345.0
HFD2_k127_3541739_3 metal-dependent phosphohydrolase HD sub K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000002079 263.0
HFD2_k127_3541739_4 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000000000000002513 178.0
HFD2_k127_3541739_5 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000005532 120.0
HFD2_k127_3541739_7 Predicted membrane protein (DUF2232) - - - 0.00000000000000000000000000009578 127.0
HFD2_k127_3541739_8 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000001285 99.0
HFD2_k127_3553283_0 Catalyzes the synthesis of GMP from XMP K01951,K03790 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 7.495e-213 672.0
HFD2_k127_3553283_1 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001714 274.0
HFD2_k127_3553283_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000006702 231.0
HFD2_k127_3553283_3 Cytochrome c554 and c-prime - - - 0.00000009365 57.0
HFD2_k127_3571430_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 5.605e-226 715.0
HFD2_k127_3571430_1 PFAM Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 464.0
HFD2_k127_3571430_2 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 408.0
HFD2_k127_3571430_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000003503 231.0
HFD2_k127_3571430_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000004666 187.0
HFD2_k127_3571430_5 PFAM Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000000000003485 109.0
HFD2_k127_3571430_6 Nitrogen-fixing NifU domain protein - - - 0.00000000000000000000004654 99.0
HFD2_k127_3571430_7 electron transfer activity K05337 - - 0.00000000000001068 76.0
HFD2_k127_3571430_8 - - - - 0.000000000001075 70.0
HFD2_k127_3571430_9 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000002999 59.0
HFD2_k127_3599240_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 527.0
HFD2_k127_3599240_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 510.0
HFD2_k127_3599240_10 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000001357 160.0
HFD2_k127_3599240_11 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000001826 135.0
HFD2_k127_3599240_12 DivIVA protein K04074 - - 0.00000000000000000000000000003786 122.0
HFD2_k127_3599240_13 YGGT family K02221 - - 0.0000000000000000000000000001141 121.0
HFD2_k127_3599240_14 DUF167 K09131 - - 0.000000000000000000001467 97.0
HFD2_k127_3599240_15 regulatory protein RecX K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000001949 93.0
HFD2_k127_3599240_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 415.0
HFD2_k127_3599240_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 368.0
HFD2_k127_3599240_4 TIGRFAM competence damage-inducible protein CinA K03742,K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000002672 267.0
HFD2_k127_3599240_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000007573 257.0
HFD2_k127_3599240_6 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000001316 250.0
HFD2_k127_3599240_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000008694 243.0
HFD2_k127_3599240_8 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000002752 236.0
HFD2_k127_3599240_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000957 198.0
HFD2_k127_3601182_0 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 466.0
HFD2_k127_3601182_1 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007435 272.0
HFD2_k127_3601182_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001782 274.0
HFD2_k127_3601182_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000001251 224.0
HFD2_k127_3601182_4 ABC transporter K01995,K01998 - - 0.00000000000000000000000000000000000005833 145.0
HFD2_k127_3618789_0 Doubled CXXCH motif (Paired_CXXCH_1) - - - 1.606e-259 835.0
HFD2_k127_3618789_1 Cytochrome c3 - - - 3.777e-244 790.0
HFD2_k127_3618789_10 6 heme-binding sites - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 303.0
HFD2_k127_3618789_11 6 heme-binding sites - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 298.0
HFD2_k127_3618789_12 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003129 261.0
HFD2_k127_3618789_13 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005303 265.0
HFD2_k127_3618789_14 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006752 260.0
HFD2_k127_3618789_15 Putative bacterial lipoprotein (DUF799) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001395 241.0
HFD2_k127_3618789_16 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000001321 155.0
HFD2_k127_3618789_17 Protein of unknown function (DUF1722) - - - 0.00000000000000000000002082 100.0
HFD2_k127_3618789_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 590.0
HFD2_k127_3618789_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 514.0
HFD2_k127_3618789_4 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 522.0
HFD2_k127_3618789_5 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 414.0
HFD2_k127_3618789_6 PPIC-type PPIASE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 405.0
HFD2_k127_3618789_7 6 heme-binding sites - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008746 389.0
HFD2_k127_3618789_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 388.0
HFD2_k127_3618789_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 300.0
HFD2_k127_365209_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1518.0
HFD2_k127_365209_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 537.0
HFD2_k127_365209_2 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006279 317.0
HFD2_k127_365209_3 PFAM Sodium calcium exchanger membrane region K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 313.0
HFD2_k127_365209_4 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001721 275.0
HFD2_k127_365209_5 - - - - 0.00000000006573 68.0
HFD2_k127_365209_6 - - - - 0.0002209 47.0
HFD2_k127_3661349_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.251e-254 794.0
HFD2_k127_3661349_1 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 363.0
HFD2_k127_3661349_2 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 297.0
HFD2_k127_3661349_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007225 271.0
HFD2_k127_3661349_4 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000009174 170.0
HFD2_k127_3661349_5 - - - - 0.0000000000000000000000000000000000001132 157.0
HFD2_k127_3713698_0 reductase, alpha subunit K00394 - 1.8.99.2 2.701e-302 938.0
HFD2_k127_3713698_1 Heterodisulfide reductase subunit A and related polyferredoxins K16886 - - 1.28e-291 913.0
HFD2_k127_3713698_2 FAD dependent oxidoreductase K16885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 561.0
HFD2_k127_3713698_3 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 456.0
HFD2_k127_3713698_4 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 434.0
HFD2_k127_3713698_5 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 314.0
HFD2_k127_3713698_6 reductase, beta subunit K00395 - 1.8.99.2 0.0000000000000000000000000000000000000000000000000000000000000009456 220.0
HFD2_k127_3713698_7 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000000001278 226.0
HFD2_k127_3833453_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586,K05366 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.1.129,3.4.16.4,4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 540.0
HFD2_k127_3833453_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 529.0
HFD2_k127_3833453_10 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 338.0
HFD2_k127_3833453_11 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 338.0
HFD2_k127_3833453_12 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 311.0
HFD2_k127_3833453_13 fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008417 307.0
HFD2_k127_3833453_14 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 303.0
HFD2_k127_3833453_15 Domains REC, HisKA, HATPase_c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004826 268.0
HFD2_k127_3833453_16 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005852 263.0
HFD2_k127_3833453_17 Dam-replacing family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009516 241.0
HFD2_k127_3833453_18 SMART Signal transduction response regulator, receiver region - - - 0.000000000000000000000000000000000000000000000000000000000000004548 219.0
HFD2_k127_3833453_19 Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000007788 217.0
HFD2_k127_3833453_2 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 502.0
HFD2_k127_3833453_20 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.0000000000000000000000000006282 130.0
HFD2_k127_3833453_21 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000001809 109.0
HFD2_k127_3833453_22 Tetratricopeptide repeat - - - 0.00000000000000000000002831 106.0
HFD2_k127_3833453_23 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000003079 96.0
HFD2_k127_3833453_3 PFAM natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 501.0
HFD2_k127_3833453_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 408.0
HFD2_k127_3833453_5 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 405.0
HFD2_k127_3833453_6 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 391.0
HFD2_k127_3833453_7 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 340.0
HFD2_k127_3833453_8 glycogen (starch) synthase activity K00703,K00754 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007142 340.0
HFD2_k127_3833453_9 Aminotransferase K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009422 329.0
HFD2_k127_3936227_0 PFAM type II secretion system protein E K02283,K03609 - - 9.197e-195 618.0
HFD2_k127_3936227_1 Pilus formation protein N terminal region K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001283 282.0
HFD2_k127_3936227_10 Psort location CytoplasmicMembrane, score - - - 0.00000000001151 68.0
HFD2_k127_3936227_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001158 256.0
HFD2_k127_3936227_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000006887 253.0
HFD2_k127_3936227_4 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000004765 235.0
HFD2_k127_3936227_5 NUBPL iron-transfer P-loop NTPase K02282 - - 0.000000000000000000000000000000000000000000000000000000000000005835 231.0
HFD2_k127_3936227_6 Flp pilus assembly protein K12511 - - 0.0000000000000000000000000000000000000000000000000000000000001645 223.0
HFD2_k127_3936227_7 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000000000003018 112.0
HFD2_k127_3936227_8 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000004867 105.0
HFD2_k127_3936227_9 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000002702 99.0
HFD2_k127_3974984_0 SMART Elongator protein 3 MiaB NifB - - - 1.719e-234 730.0
HFD2_k127_3974984_1 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 543.0
HFD2_k127_3974984_10 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008821 259.0
HFD2_k127_3974984_11 PFAM permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001749 261.0
HFD2_k127_3974984_12 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000002926 222.0
HFD2_k127_3974984_13 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.000000000000000000000000000000000000000000000000000001505 198.0
HFD2_k127_3974984_14 PFAM Glycosyl transferase, family 39 - - - 0.0000000000000000000000000000000000000000000000000002443 206.0
HFD2_k127_3974984_15 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000001299 186.0
HFD2_k127_3974984_16 Cys-tRNA(Pro) hydrolase activity K03976,K19055 - - 0.000000000000000000000000000000000000000000131 164.0
HFD2_k127_3974984_17 Protein of unknown function (DUF3047) - - - 0.0000000000000000000000000000000000000000004253 166.0
HFD2_k127_3974984_18 cheY-homologous receiver domain - - - 0.0000000000000000000000000000001549 127.0
HFD2_k127_3974984_19 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000007497 99.0
HFD2_k127_3974984_2 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 342.0
HFD2_k127_3974984_20 Protein tyrosine kinase - - - 0.0000000000002741 76.0
HFD2_k127_3974984_21 Universal stress protein family - - - 0.00000002113 62.0
HFD2_k127_3974984_23 Protein of unknown function (DUF2892) - - - 0.0005155 46.0
HFD2_k127_3974984_3 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 315.0
HFD2_k127_3974984_4 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 294.0
HFD2_k127_3974984_5 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 310.0
HFD2_k127_3974984_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 306.0
HFD2_k127_3974984_7 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000235 306.0
HFD2_k127_3974984_8 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002531 275.0
HFD2_k127_3974984_9 Permease YjgP YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006752 271.0
HFD2_k127_4411711_0 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 512.0
HFD2_k127_4411711_1 Seven times multi-haem cytochrome CxxCH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 498.0
HFD2_k127_4411711_10 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000000000000000000000000000989 118.0
HFD2_k127_4411711_11 Sporulation and spore germination - - - 0.00000000000000000000000000105 123.0
HFD2_k127_4411711_12 Ami_3 K01448 - 3.5.1.28 0.000000000000000000003437 106.0
HFD2_k127_4411711_13 alginic acid biosynthetic process - - - 0.000000000000000004843 92.0
HFD2_k127_4411711_14 periplasmic or secreted lipoprotein - - - 0.00000000000000006554 81.0
HFD2_k127_4411711_2 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 407.0
HFD2_k127_4411711_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 304.0
HFD2_k127_4411711_4 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006249 241.0
HFD2_k127_4411711_5 - - - - 0.0000000000000000000000000000000000000000000000000000000001401 218.0
HFD2_k127_4411711_6 - - - - 0.0000000000000000000000000000000000000000000000000000000003776 213.0
HFD2_k127_4411711_7 FMN binding K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000000008015 170.0
HFD2_k127_4411711_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000002448 137.0
HFD2_k127_4411711_9 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000006275 128.0
HFD2_k127_4461981_0 Phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 504.0
HFD2_k127_4461981_1 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 318.0
HFD2_k127_4461981_2 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009808 276.0
HFD2_k127_4461981_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000001341 247.0
HFD2_k127_4461981_4 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000002073 243.0
HFD2_k127_4461981_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004057 234.0
HFD2_k127_4461981_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006807,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0020037,GO:0042279,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0097164,GO:0098809,GO:1901363 - 0.000000000000000000000000436 117.0
HFD2_k127_4461981_8 AMP binding - - - 0.000000000001869 69.0
HFD2_k127_4462487_0 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 486.0
HFD2_k127_4462487_1 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002335 252.0
HFD2_k127_4462487_2 Glycosyl transferase family group 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001279 250.0
HFD2_k127_4462487_3 glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000812 211.0
HFD2_k127_4462487_4 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000001334 97.0
HFD2_k127_4462487_5 Glycosyltransferase Family 4 - - - 0.000000000004022 68.0
HFD2_k127_4466055_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 4.413e-318 996.0
HFD2_k127_4466055_1 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009382 493.0
HFD2_k127_4466055_2 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 404.0
HFD2_k127_4466055_3 metallopeptidase activity K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 326.0
HFD2_k127_4466055_4 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000001149 179.0
HFD2_k127_4466055_5 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000000000000000002008 170.0
HFD2_k127_4466055_6 Psort location CytoplasmicMembrane, score K00368 - 1.7.2.1 0.00000000000000000000000000001796 135.0
HFD2_k127_4466055_7 - - - - 0.00001168 51.0
HFD2_k127_4466055_8 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00005222 55.0
HFD2_k127_4471121_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1018.0
HFD2_k127_4471121_1 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 337.0
HFD2_k127_4471121_2 Binds the 23S rRNA K02909 - - 0.000000000000000000000000002222 112.0
HFD2_k127_4471121_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0001668 44.0
HFD2_k127_4491876_0 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 586.0
HFD2_k127_4491876_1 Uncharacterized protein family UPF0004 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 402.0
HFD2_k127_4491876_10 Pfam:Arch_ATPase - - - 0.000000000000000000000000000000000000000000002293 167.0
HFD2_k127_4491876_11 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000001318 151.0
HFD2_k127_4491876_12 ATP hydrolysis coupled proton transport K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000009406 106.0
HFD2_k127_4491876_2 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 357.0
HFD2_k127_4491876_3 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000004187 243.0
HFD2_k127_4491876_4 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002833 255.0
HFD2_k127_4491876_5 regulator, PATAN and FRGAF domain-containing - - - 0.0000000000000000000000000000000000000000000000000000000000000000001954 244.0
HFD2_k127_4491876_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000006394 250.0
HFD2_k127_4491876_7 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000004889 225.0
HFD2_k127_4491876_8 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000008003 215.0
HFD2_k127_4491876_9 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000002651 216.0
HFD2_k127_4541098_0 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 1.171e-241 770.0
HFD2_k127_4541098_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 517.0
HFD2_k127_4541098_10 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000000000000000005732 249.0
HFD2_k127_4541098_11 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.00000000000000000000000000000000000000000000000000000000001123 221.0
HFD2_k127_4541098_12 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000009118 201.0
HFD2_k127_4541098_13 PFAM Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000469 184.0
HFD2_k127_4541098_14 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000002355 181.0
HFD2_k127_4541098_15 Belongs to the LTA synthase family - - - 0.000000000000000000000000000000000000000000964 179.0
HFD2_k127_4541098_16 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000008807 129.0
HFD2_k127_4541098_17 denitrification pathway - - - 0.00000000008655 74.0
HFD2_k127_4541098_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 472.0
HFD2_k127_4541098_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 450.0
HFD2_k127_4541098_4 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 353.0
HFD2_k127_4541098_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 323.0
HFD2_k127_4541098_6 AhpC/TSA family K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 296.0
HFD2_k127_4541098_7 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001827 272.0
HFD2_k127_4541098_8 PFAM HhH-GPD family protein K07457 - - 0.000000000000000000000000000000000000000000000000000000000000000000003573 253.0
HFD2_k127_4541098_9 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000003689 241.0
HFD2_k127_4698345_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 3.534e-248 777.0
HFD2_k127_4698345_1 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 615.0
HFD2_k127_4698345_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000001322 234.0
HFD2_k127_4698345_3 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000002473 182.0
HFD2_k127_4698345_4 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000007801 104.0
HFD2_k127_4698345_5 protein histidine kinase activity K13924 - 2.1.1.80,3.1.1.61 0.0000000000002301 79.0
HFD2_k127_4698345_6 EamA-like transporter family - - - 0.00000000000143 78.0
HFD2_k127_4698345_7 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.000000000001497 75.0
HFD2_k127_4698345_8 Mut7-C ubiquitin K03154 - - 0.00000006482 59.0
HFD2_k127_4744351_0 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000628 445.0
HFD2_k127_4744351_1 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 416.0
HFD2_k127_4744351_10 PFAM ABC transporter K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000005144 220.0
HFD2_k127_4744351_11 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000008754 195.0
HFD2_k127_4744351_12 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000005319 204.0
HFD2_k127_4744351_13 Putative RNA methylase family UPF0020 K03427 - 2.1.1.72 0.0000000000000000000000000000157 118.0
HFD2_k127_4744351_14 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000192 127.0
HFD2_k127_4744351_15 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000006857 120.0
HFD2_k127_4744351_16 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000001923 97.0
HFD2_k127_4744351_17 thiamine biosynthesis protein ThiS K03154 - - 0.000000000000004616 76.0
HFD2_k127_4744351_18 Domain of unknown function (DUF4082) - - - 0.000000000000005387 91.0
HFD2_k127_4744351_19 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000004125 79.0
HFD2_k127_4744351_2 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 395.0
HFD2_k127_4744351_20 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000001636 73.0
HFD2_k127_4744351_21 Chaperone protein DNAj - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.0000005484 62.0
HFD2_k127_4744351_22 Domain of unknown function (DUF4082) - - - 0.00002425 59.0
HFD2_k127_4744351_23 sequence-specific DNA binding - - - 0.0002511 49.0
HFD2_k127_4744351_3 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 378.0
HFD2_k127_4744351_4 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 364.0
HFD2_k127_4744351_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 379.0
HFD2_k127_4744351_6 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 355.0
HFD2_k127_4744351_7 S-layer homology domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 379.0
HFD2_k127_4744351_8 Elongator protein 3, MiaB family, Radical SAM K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 326.0
HFD2_k127_4744351_9 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000001935 263.0
HFD2_k127_476830_0 biosynthesis protein ThiH K03150 - 4.1.99.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007034 443.0
HFD2_k127_476830_1 ThiS-like ubiquitin K03148 - 2.7.7.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 311.0
HFD2_k127_476830_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000006423 199.0
HFD2_k127_476830_3 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000001354 184.0
HFD2_k127_476830_4 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000002465 180.0
HFD2_k127_4798854_0 Elongator protein 3, MiaB family, Radical SAM - - - 1.754e-195 634.0
HFD2_k127_4798854_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 352.0
HFD2_k127_4798854_2 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 296.0
HFD2_k127_4798854_3 Surface antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006028 285.0
HFD2_k127_4798854_4 EamA-like transporter family - - - 0.000000000000000000000001081 108.0
HFD2_k127_4798854_5 Tetratricopeptide repeat - - - 0.000000000000000001688 95.0
HFD2_k127_4798854_6 NmrA-like family K00091 - 1.1.1.219 0.0000000001004 63.0
HFD2_k127_4798854_7 Lipid A 3-O-deacylase (PagL) - - - 0.00000001168 65.0
HFD2_k127_4803384_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 413.0
HFD2_k127_4803384_1 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000004532 239.0
HFD2_k127_4803384_2 PFAM response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000000000000000000004614 154.0
HFD2_k127_4803384_3 5'-nucleotidase - - - 0.0000000000000000000000000000000000004919 156.0
HFD2_k127_4892873_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 469.0
HFD2_k127_4892873_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 453.0
HFD2_k127_4892873_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001153 286.0
HFD2_k127_4892873_3 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.000000000000000000000000000000000000000000000000000000000000005941 231.0
HFD2_k127_4892873_4 Asparaginase K01424,K13051 - 3.4.19.5,3.5.1.1 0.000000000000000000000000000000000000000000000000000000000001776 221.0
HFD2_k127_4892873_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000003179 53.0
HFD2_k127_4893667_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 441.0
HFD2_k127_4893667_1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 417.0
HFD2_k127_4893667_10 Dodecin K09165 - - 0.000000000000001295 78.0
HFD2_k127_4893667_2 Thiamine biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 330.0
HFD2_k127_4893667_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 325.0
HFD2_k127_4893667_4 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 293.0
HFD2_k127_4893667_5 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.00000000000000000000000000000000000000000000000000000000000000000000003737 255.0
HFD2_k127_4893667_6 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000002891 198.0
HFD2_k127_4893667_7 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000021 174.0
HFD2_k127_4893667_8 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000004793 182.0
HFD2_k127_4893667_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000133 157.0
HFD2_k127_49203_0 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 527.0
HFD2_k127_49203_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 491.0
HFD2_k127_49203_2 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 328.0
HFD2_k127_4926422_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K05551 - 2.3.1.235,2.3.1.260 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 431.0
HFD2_k127_4926422_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 300.0
HFD2_k127_4926422_2 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.000000000000000000000000000000000000000003278 164.0
HFD2_k127_4926422_3 - - - - 0.000003484 53.0
HFD2_k127_4926422_4 - - - - 0.0001065 48.0
HFD2_k127_5030284_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1075.0
HFD2_k127_5030284_1 Ribulose bisphosphate carboxylase large chain, N-terminal domain K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 372.0
HFD2_k127_5030284_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000002971 184.0
HFD2_k127_5030284_3 TIGRFAM TIGR00268 family protein K06864 - - 0.000000000000000000000000000000000001575 141.0
HFD2_k127_5030284_4 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000561 104.0
HFD2_k127_5030284_5 Tetratricopeptide repeat - - - 0.000000000000000000002244 103.0
HFD2_k127_5030284_6 - - - - 0.00000000000000001685 87.0
HFD2_k127_5030284_7 monooxygenase activity - - - 0.0000000002944 65.0
HFD2_k127_5030284_8 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0002039 47.0
HFD2_k127_5068843_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K00533 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.12.2.1,1.12.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 591.0
HFD2_k127_5068843_1 Belongs to the precorrin methyltransferase family K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 307.0
HFD2_k127_5068843_10 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000005846 79.0
HFD2_k127_5068843_11 - - - - 0.0000000000001234 73.0
HFD2_k127_5068843_2 Hydrogenase (NiFe) small subunit HydA K05927,K06282,K18008 - 1.12.2.1,1.12.5.1,1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 309.0
HFD2_k127_5068843_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 308.0
HFD2_k127_5068843_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 295.0
HFD2_k127_5068843_5 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000006953 268.0
HFD2_k127_5068843_6 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000003736 224.0
HFD2_k127_5068843_7 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.000000000000000000000000000000000000000000000000000000009776 207.0
HFD2_k127_5068843_8 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000000000172 131.0
HFD2_k127_5068843_9 Prokaryotic cytochrome b561 K03620 - - 0.00000000000000000000000003994 116.0
HFD2_k127_5072896_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005266 597.0
HFD2_k127_5072896_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 357.0
HFD2_k127_5072896_2 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000002162 212.0
HFD2_k127_5072896_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000001963 188.0
HFD2_k127_5072896_4 Domain of unknown function (DUF370) K09777 - - 0.00000000000000000000002553 99.0
HFD2_k127_5072896_5 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000036 72.0
HFD2_k127_5074516_0 ABC transporter, ATP-binding protein K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 488.0
HFD2_k127_5074516_1 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007485 280.0
HFD2_k127_5074516_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000002533 89.0
HFD2_k127_5074516_3 Acetoacetate decarboxylase (ADC) - - - 0.000000000001004 77.0
HFD2_k127_5169559_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 5.062e-199 648.0
HFD2_k127_5169559_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 465.0
HFD2_k127_5169559_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005242 280.0
HFD2_k127_5169559_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000005436 267.0
HFD2_k127_5169559_4 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000002399 217.0
HFD2_k127_5169559_5 cyclohydrolase K01746 - 4.3.1.4 0.000000000000000000000000000000000000000000000009152 178.0
HFD2_k127_5169559_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.0000000000000000000000000004964 126.0
HFD2_k127_5169559_7 - - - - 0.0000000000000000000001326 106.0
HFD2_k127_5169559_8 Universal stress protein - - - 0.00000000005087 72.0
HFD2_k127_5265230_0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 331.0
HFD2_k127_5265230_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000005365 265.0
HFD2_k127_5265230_2 Lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000009436 181.0
HFD2_k127_5265230_3 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000003727 110.0
HFD2_k127_5265230_4 Domain of unknown function (DUF374) K09778 - - 0.00000001019 63.0
HFD2_k127_5299597_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 418.0
HFD2_k127_5299597_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000000000000004809 250.0
HFD2_k127_5299597_2 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000005655 250.0
HFD2_k127_5299597_3 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000008401 246.0
HFD2_k127_5299597_4 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000003536 225.0
HFD2_k127_5299597_5 COG1233 Phytoene dehydrogenase and related - - - 0.00000000000000000000000000000000000000000000000000000001252 217.0
HFD2_k127_5299597_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000005975 184.0
HFD2_k127_5299597_7 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.00000000000000000001208 93.0
HFD2_k127_5317954_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 614.0
HFD2_k127_5317954_1 Multicopper oxidase K06324 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 521.0
HFD2_k127_5317954_10 Serine threonine protein kinase - - - 0.00002168 54.0
HFD2_k127_5317954_2 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 314.0
HFD2_k127_5317954_3 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 310.0
HFD2_k127_5317954_4 radical SAM domain protein - - - 0.0000000000000000000000000000001757 135.0
HFD2_k127_5317954_5 COGs COG1900 conserved - - - 0.000000000000000000000000000002259 123.0
HFD2_k127_5317954_6 NIL - - - 0.000000000000000000000000000002433 124.0
HFD2_k127_5317954_7 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000006322 113.0
HFD2_k127_5317954_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000013 86.0
HFD2_k127_5317954_9 Protein of unknown function (DUF3024) - - - 0.0000009533 56.0
HFD2_k127_5344445_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.0 1273.0
HFD2_k127_5344445_1 Aminotransferase class I and II K14261 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 600.0
HFD2_k127_5344445_10 Domain of unknown function (DUF4911) - - - 0.0001017 52.0
HFD2_k127_5344445_2 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 556.0
HFD2_k127_5344445_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 535.0
HFD2_k127_5344445_4 Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000566 507.0
HFD2_k127_5344445_5 Proposed homoserine kinase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 480.0
HFD2_k127_5344445_6 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 411.0
HFD2_k127_5344445_7 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 349.0
HFD2_k127_5344445_8 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.00000000000000000341 88.0
HFD2_k127_5344445_9 nuclease - - - 0.00000000000000004951 84.0
HFD2_k127_5408746_0 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 1.728e-218 714.0
HFD2_k127_5408746_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 509.0
HFD2_k127_5408746_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005946 439.0
HFD2_k127_5408746_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 421.0
HFD2_k127_5408746_4 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 318.0
HFD2_k127_5408746_5 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005381 274.0
HFD2_k127_5408746_6 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000003093 237.0
HFD2_k127_5408746_7 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000001638 139.0
HFD2_k127_5408746_8 cyclic nucleotide binding K10914 - - 0.00000000000000005374 87.0
HFD2_k127_5469587_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 6.725e-283 900.0
HFD2_k127_5469587_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 502.0
HFD2_k127_5469587_2 - - - - 0.0000000000000000000000000000000000002999 147.0
HFD2_k127_5469587_3 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.000000000000000000000009703 103.0
HFD2_k127_5474782_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 2.614e-250 781.0
HFD2_k127_5474782_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 361.0
HFD2_k127_5474782_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000005935 208.0
HFD2_k127_5474949_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.0 1293.0
HFD2_k127_5474949_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 403.0
HFD2_k127_5474949_2 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000000000000000005321 211.0
HFD2_k127_5474949_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000007645 196.0
HFD2_k127_5600385_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 3.078e-243 759.0
HFD2_k127_5600385_1 PFAM Rh family protein ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 598.0
HFD2_k127_5600385_10 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000000000000000000009274 179.0
HFD2_k127_5600385_11 Ribonuclease H K03469 - 3.1.26.4 0.0000000000000000000000000000000000000217 151.0
HFD2_k127_5600385_12 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000002213 124.0
HFD2_k127_5600385_13 Alpha beta - - - 0.000000000000003461 85.0
HFD2_k127_5600385_14 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0001512 54.0
HFD2_k127_5600385_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 511.0
HFD2_k127_5600385_3 Ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000845 459.0
HFD2_k127_5600385_4 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 387.0
HFD2_k127_5600385_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 376.0
HFD2_k127_5600385_6 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 355.0
HFD2_k127_5600385_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000009946 222.0
HFD2_k127_5600385_8 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.00000000000000000000000000000000000000000000000000000002103 207.0
HFD2_k127_5600385_9 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000000604 196.0
HFD2_k127_5779047_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.65e-245 771.0
HFD2_k127_5779047_1 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003169 281.0
HFD2_k127_5779047_2 COGs COG1900 conserved - - - 0.000000000000000000000000000002259 123.0
HFD2_k127_5779047_3 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000001451 58.0
HFD2_k127_5878803_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 4.216e-313 971.0
HFD2_k127_5878803_1 glucan 1,4-alpha-glucosidase activity - - - 2.625e-251 791.0
HFD2_k127_5878803_10 Fibronectin type 3 domain K20276 - - 0.00000000000000000000000000001227 138.0
HFD2_k127_5878803_12 fibronectin type III domain protein - - - 0.0000000000001126 81.0
HFD2_k127_5878803_13 Sodium:solute symporter family K14393 - - 0.0000000000001431 74.0
HFD2_k127_5878803_14 fibronectin type III domain protein - - - 0.00000000002167 76.0
HFD2_k127_5878803_16 phosphate-selective porin O and P K07221 - - 0.00000001883 67.0
HFD2_k127_5878803_17 - - - - 0.0000000387 59.0
HFD2_k127_5878803_18 regulator of chromosome condensation, RCC1 - - - 0.000005126 59.0
HFD2_k127_5878803_2 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 561.0
HFD2_k127_5878803_3 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 377.0
HFD2_k127_5878803_4 Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 367.0
HFD2_k127_5878803_5 Pyridine nucleotide-disulphide oxidoreductase K00529,K18227,K18249 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 362.0
HFD2_k127_5878803_6 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 364.0
HFD2_k127_5878803_7 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 324.0
HFD2_k127_5878803_8 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000000002512 189.0
HFD2_k127_6141398_0 NAD synthase K01916 - 6.3.1.5 6.181e-214 680.0
HFD2_k127_6141398_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 9.635e-208 656.0
HFD2_k127_6141398_10 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 293.0
HFD2_k127_6141398_11 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009443 294.0
HFD2_k127_6141398_12 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002351 279.0
HFD2_k127_6141398_13 nitric oxide dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001308 296.0
HFD2_k127_6141398_14 denitrification pathway K02569,K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000001077 257.0
HFD2_k127_6141398_15 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005006 250.0
HFD2_k127_6141398_16 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005517 248.0
HFD2_k127_6141398_17 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000005958 230.0
HFD2_k127_6141398_18 denitrification pathway K00380 - 1.8.1.2 0.00000000000000000000000000000000000000000000000001642 203.0
HFD2_k127_6141398_19 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000001049 176.0
HFD2_k127_6141398_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 6.454e-201 635.0
HFD2_k127_6141398_20 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000004769 186.0
HFD2_k127_6141398_21 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000002855 164.0
HFD2_k127_6141398_22 Putative cyclase K07130 - 3.5.1.9 0.0000000000000000000000000000000000000002112 157.0
HFD2_k127_6141398_23 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.0000000000000000000000000000000000004329 161.0
HFD2_k127_6141398_24 Zinc ion binding K11997,K12035 GO:0003008,GO:0003012,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007610,GO:0007626,GO:0008150,GO:0008152,GO:0008270,GO:0008345,GO:0009653,GO:0009987,GO:0010927,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030239,GO:0030537,GO:0031032,GO:0031674,GO:0032446,GO:0032501,GO:0032502,GO:0032989,GO:0036211,GO:0042592,GO:0042692,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043292,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044464,GO:0046716,GO:0046872,GO:0046914,GO:0048468,GO:0048646,GO:0048747,GO:0048856,GO:0048869,GO:0051146,GO:0055001,GO:0055002,GO:0060249,GO:0061061,GO:0065007,GO:0065008,GO:0070647,GO:0070925,GO:0071704,GO:0071840,GO:0097435,GO:0099080,GO:0099081,GO:0099512,GO:0140096,GO:1901564 2.3.2.27 0.0000000000000000000000000000000001041 151.0
HFD2_k127_6141398_25 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000001607 130.0
HFD2_k127_6141398_26 Protein of unknown function (DUF559) K07316 - 2.1.1.72 0.0000000000000000000000002987 108.0
HFD2_k127_6141398_27 amine dehydrogenase activity - - - 0.0000000000000000000000003737 121.0
HFD2_k127_6141398_29 Domain of unknown function (DUF4412) - - - 0.0000000000000000000004705 105.0
HFD2_k127_6141398_3 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007017 494.0
HFD2_k127_6141398_30 signal-transduction protein containing cAMP-binding and CBS domains K00031,K14446 - 1.1.1.42,1.3.1.85 0.0000000000000000000009754 100.0
HFD2_k127_6141398_31 regulatory protein, FmdB family - - - 0.000000000000000000005388 96.0
HFD2_k127_6141398_32 PPIC-type PPIASE domain K01802,K03769 - 5.2.1.8 0.000000000000000000008718 102.0
HFD2_k127_6141398_33 COG1404 Subtilisin-like serine proteases K13276 - - 0.0000000002653 73.0
HFD2_k127_6141398_4 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255,K01259 GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 442.0
HFD2_k127_6141398_5 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 397.0
HFD2_k127_6141398_6 Peptidase M16 domain protein K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 385.0
HFD2_k127_6141398_7 Belongs to the RtcB family K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 358.0
HFD2_k127_6141398_8 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 340.0
HFD2_k127_6141398_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 303.0
HFD2_k127_6171761_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 490.0
HFD2_k127_6171761_1 helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 454.0
HFD2_k127_6171761_2 alcohol dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000297 205.0
HFD2_k127_6176021_0 nitrogenase component I, alpha chain K02586 - 1.18.6.1 2.338e-226 712.0
HFD2_k127_6176021_1 GAF domain K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 521.0
HFD2_k127_6176021_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588,K04037,K11333 - 1.18.6.1,1.3.7.14,1.3.7.15,1.3.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 469.0
HFD2_k127_6176021_3 Biotin-lipoyl like K19595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 444.0
HFD2_k127_6176021_4 Fibronectin type 3 domain K20276 - - 0.000000000000000000000000000000000006279 160.0
HFD2_k127_6176021_5 AcrB/AcrD/AcrF family K03296,K19594 - - 0.0000000001619 61.0
HFD2_k127_6199411_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 2.173e-228 720.0
HFD2_k127_6199411_1 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 578.0
HFD2_k127_6199411_10 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000007323 237.0
HFD2_k127_6199411_11 -O-antigen K02847,K13009,K16705 GO:0003674,GO:0003824,GO:0006464,GO:0006486,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0016740,GO:0016757,GO:0019538,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000003936 216.0
HFD2_k127_6199411_12 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000001929 196.0
HFD2_k127_6199411_13 AI-2E family transporter - - - 0.000000000000000000000000000000000000000001375 161.0
HFD2_k127_6199411_14 Type IV pilin PilA K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0000000000000000000000000006184 119.0
HFD2_k127_6199411_15 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000008408 112.0
HFD2_k127_6199411_16 Type IV pilin PilA K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.00000000000000000000000001136 119.0
HFD2_k127_6199411_17 Prokaryotic N-terminal methylation motif K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000000000000000000000004397 108.0
HFD2_k127_6199411_18 COG3307 Lipid A core - O-antigen ligase and related enzymes K18814 - - 0.0000000000000000008356 101.0
HFD2_k127_6199411_19 - - - - 0.00000000000002566 80.0
HFD2_k127_6199411_2 phosphorelay signal transduction system K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 529.0
HFD2_k127_6199411_3 Type II secretion system (T2SS), protein F K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 490.0
HFD2_k127_6199411_4 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 400.0
HFD2_k127_6199411_5 Fe-S oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 374.0
HFD2_k127_6199411_6 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 338.0
HFD2_k127_6199411_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 315.0
HFD2_k127_6199411_8 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000001383 269.0
HFD2_k127_6199411_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000006905 236.0
HFD2_k127_6203777_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 4.25e-214 677.0
HFD2_k127_6203777_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 582.0
HFD2_k127_6203777_10 PAP2 superfamily - - - 0.00000000000000000000000000000000006546 145.0
HFD2_k127_6203777_11 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000001009 109.0
HFD2_k127_6203777_12 CAAX protease self-immunity - - - 0.0000000000000000000839 98.0
HFD2_k127_6203777_13 phytol kinase activity K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.0000000000000002771 86.0
HFD2_k127_6203777_14 Ferrous iron transport protein B K04759 - - 0.00000000000005085 72.0
HFD2_k127_6203777_15 Tetratricopeptide repeats - - - 0.0000001309 57.0
HFD2_k127_6203777_16 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0004651 51.0
HFD2_k127_6203777_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 516.0
HFD2_k127_6203777_3 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 495.0
HFD2_k127_6203777_4 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 491.0
HFD2_k127_6203777_5 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 353.0
HFD2_k127_6203777_6 NAD(P)H-binding K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000003098 261.0
HFD2_k127_6203777_7 polyketide synthase K21792 - - 0.000000000000000000000000000000000000000000000000000000000000006694 228.0
HFD2_k127_6203777_8 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000007299 177.0
HFD2_k127_6203777_9 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000131 166.0
HFD2_k127_6208028_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 503.0
HFD2_k127_6208028_1 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 482.0
HFD2_k127_6208028_10 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002157 263.0
HFD2_k127_6208028_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000008993 176.0
HFD2_k127_6208028_12 Conserved hypothetical protein 95 - - - 0.000000000000000000000000000000000000001224 153.0
HFD2_k127_6208028_13 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000008841 147.0
HFD2_k127_6208028_14 Methyltransferase type 12 - - - 0.0000000000000000000000000000000000009583 153.0
HFD2_k127_6208028_15 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000004185 134.0
HFD2_k127_6208028_16 B12 binding domain - - - 0.0000000000000000000000000004679 123.0
HFD2_k127_6208028_17 PFAM Nitrous oxide-stimulated promoter - - - 0.000000000000000000000000008483 111.0
HFD2_k127_6208028_18 PFAM Rhodanese-like domain - - - 0.000000000000000000000001776 111.0
HFD2_k127_6208028_19 Putative regulatory protein - - - 0.0000000000000009893 78.0
HFD2_k127_6208028_2 FAD linked oxidase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 477.0
HFD2_k127_6208028_20 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000002219 91.0
HFD2_k127_6208028_21 - - - - 0.00000000001042 77.0
HFD2_k127_6208028_22 PFAM Methyltransferase type 11 - - - 0.000000001229 67.0
HFD2_k127_6208028_3 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 401.0
HFD2_k127_6208028_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 353.0
HFD2_k127_6208028_5 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 314.0
HFD2_k127_6208028_6 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 301.0
HFD2_k127_6208028_7 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 289.0
HFD2_k127_6208028_8 PFAM Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009495 290.0
HFD2_k127_6208028_9 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001442 283.0
HFD2_k127_6216362_0 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 481.0
HFD2_k127_6216362_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 469.0
HFD2_k127_6216362_2 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 353.0
HFD2_k127_6216362_3 pfam abc K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 330.0
HFD2_k127_6216362_4 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000003384 240.0
HFD2_k127_6219944_0 Acyl transferase domain K15314 - - 0.0 1701.0
HFD2_k127_6219944_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1120.0
HFD2_k127_6219944_10 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000001596 165.0
HFD2_k127_6219944_11 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000004352 167.0
HFD2_k127_6219944_12 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000002826 157.0
HFD2_k127_6219944_13 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000103 162.0
HFD2_k127_6219944_14 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000006407 121.0
HFD2_k127_6219944_15 Rubredoxin - - - 0.000000000000000000000000107 108.0
HFD2_k127_6219944_16 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000005592 102.0
HFD2_k127_6219944_17 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000001319 98.0
HFD2_k127_6219944_18 - - - - 0.0000000001048 70.0
HFD2_k127_6219944_2 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 8.02e-317 983.0
HFD2_k127_6219944_3 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 488.0
HFD2_k127_6219944_4 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 439.0
HFD2_k127_6219944_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 431.0
HFD2_k127_6219944_6 pyridine nucleotide-disulphide oxidoreductase dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 434.0
HFD2_k127_6219944_7 histidine kinase HAMP region domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001753 208.0
HFD2_k127_6219944_8 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000003051 179.0
HFD2_k127_6219944_9 Putative transmembrane protein (Alph_Pro_TM) - - - 0.000000000000000000000000000000000000000000000572 176.0
HFD2_k127_6227723_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 4.748e-220 704.0
HFD2_k127_6227723_1 PFAM Integral membrane protein TerC - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 366.0
HFD2_k127_6227723_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003006 289.0
HFD2_k127_6227723_3 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000001532 224.0
HFD2_k127_6227723_4 Thioesterase superfamily K03186 - 2.5.1.129 0.0000000000000000000000000000000002573 136.0
HFD2_k127_6227723_6 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000001333 98.0
HFD2_k127_6227723_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000006281 72.0
HFD2_k127_6227723_8 - - - - 0.000003882 58.0
HFD2_k127_6255601_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 9.448e-296 920.0
HFD2_k127_6255601_1 Glycosyl hydrolase family 57 - - - 6.521e-205 660.0
HFD2_k127_6255601_10 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 331.0
HFD2_k127_6255601_11 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 315.0
HFD2_k127_6255601_12 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 299.0
HFD2_k127_6255601_13 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 284.0
HFD2_k127_6255601_14 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002315 283.0
HFD2_k127_6255601_15 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002103 293.0
HFD2_k127_6255601_16 HPP family K07168 - - 0.000000000000000000000000000000000000000000000000000000000000000001805 234.0
HFD2_k127_6255601_17 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000001422 222.0
HFD2_k127_6255601_18 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000059 203.0
HFD2_k127_6255601_19 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000001275 180.0
HFD2_k127_6255601_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 3.339e-199 628.0
HFD2_k127_6255601_20 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000008042 154.0
HFD2_k127_6255601_21 Methylates ribosomal protein L11 K02687 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000007913 150.0
HFD2_k127_6255601_22 holo-[acyl-carrier-protein] synthase activity K00997 - 2.7.8.7 0.0000000000000000000000000001076 120.0
HFD2_k127_6255601_23 RNA recognition motif - - - 0.00000000000000000000000002923 109.0
HFD2_k127_6255601_24 Protein of unknown function, DUF488 - - - 0.00000000000000001485 89.0
HFD2_k127_6255601_25 Tetratricopeptide repeat - - - 0.0000000000000417 83.0
HFD2_k127_6255601_26 Protein of unknown function, DUF488 - - - 0.00000000000009661 76.0
HFD2_k127_6255601_27 PFAM CBS domain - - - 0.0000000000001451 74.0
HFD2_k127_6255601_28 cell cycle K05589 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944 - 0.0000001973 57.0
HFD2_k127_6255601_3 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 583.0
HFD2_k127_6255601_4 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007182 569.0
HFD2_k127_6255601_5 TIGRFAM arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009732 564.0
HFD2_k127_6255601_6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 470.0
HFD2_k127_6255601_7 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 417.0
HFD2_k127_6255601_8 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 364.0
HFD2_k127_6255601_9 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 348.0
HFD2_k127_6266953_0 4 iron, 4 sulfur cluster binding - - - 0.0 1437.0
HFD2_k127_6266953_1 Hydrogenase expression formation protein (HypE) K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 336.0
HFD2_k127_6266953_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 296.0
HFD2_k127_6266953_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001019 267.0
HFD2_k127_6266953_4 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.0000000000000000000000000702 109.0
HFD2_k127_6297767_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 596.0
HFD2_k127_6297767_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 573.0
HFD2_k127_6297767_10 Methyltransferase domain - - - 0.00000000000000000000000000002601 125.0
HFD2_k127_6297767_12 Lipid A 3-O-deacylase (PagL) - - - 0.0000007324 60.0
HFD2_k127_6297767_2 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 410.0
HFD2_k127_6297767_3 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 384.0
HFD2_k127_6297767_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 368.0
HFD2_k127_6297767_5 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 376.0
HFD2_k127_6297767_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005248 341.0
HFD2_k127_6297767_7 BadF BadG BcrA BcrD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001005 277.0
HFD2_k127_6297767_8 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000000000009536 136.0
HFD2_k127_6297767_9 - - - - 0.000000000000000000000000000000008341 130.0
HFD2_k127_6305722_0 Valyl tRNA synthetase tRNA binding arm K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1164.0
HFD2_k127_6305722_1 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 449.0
HFD2_k127_6305722_10 Belongs to the thioredoxin family K03671 - - 0.000000000000000000004064 102.0
HFD2_k127_6305722_12 - - - - 0.0000000000001161 76.0
HFD2_k127_6305722_13 - - - - 0.00000002403 64.0
HFD2_k127_6305722_14 Kdo2-lipid A biosynthetic process K02517,K20543,K22311 - 2.3.1.241,2.3.1.265 0.00000003556 57.0
HFD2_k127_6305722_15 - - - - 0.000000114 55.0
HFD2_k127_6305722_2 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 352.0
HFD2_k127_6305722_3 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 331.0
HFD2_k127_6305722_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 322.0
HFD2_k127_6305722_5 NADPH quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007942 285.0
HFD2_k127_6305722_6 PFAM Cytochrome b5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000017 266.0
HFD2_k127_6305722_7 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000001939 205.0
HFD2_k127_6305722_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000001238 194.0
HFD2_k127_6305722_9 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000001374 145.0
HFD2_k127_6352427_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1610.0
HFD2_k127_6352427_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007046 392.0
HFD2_k127_6352427_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 358.0
HFD2_k127_6352427_3 Multicopper oxidase K06324 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000001009 239.0
HFD2_k127_6352427_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000005935 208.0
HFD2_k127_6366239_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006256 397.0
HFD2_k127_6413810_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.58e-301 956.0
HFD2_k127_6413810_1 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 319.0
HFD2_k127_6413810_10 Dinitrogenase iron-molybdenum cofactor - - - 0.000000000006871 74.0
HFD2_k127_6413810_11 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000001566 66.0
HFD2_k127_6413810_12 COG0224 F0F1-type ATP synthase, gamma subunit K02115 - - 0.0000001609 59.0
HFD2_k127_6413810_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000045 206.0
HFD2_k127_6413810_3 - - - - 0.0000000000000000000000000000000000000000000000000002645 190.0
HFD2_k127_6413810_4 TIGRFAM YD repeat protein - - - 0.0000000000000000000000000000000000000000000000006878 185.0
HFD2_k127_6413810_5 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000003659 165.0
HFD2_k127_6413810_6 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000004155 145.0
HFD2_k127_6413810_7 Histidine kinase - - - 0.000000000000000000000000000000000004425 147.0
HFD2_k127_6413810_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02132 GO:0000275,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005753,GO:0006091,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0010876,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0019866,GO:0019915,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0022900,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033036,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0050790,GO:0051179,GO:0051234,GO:0051235,GO:0051338,GO:0055085,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600,GO:1902769 - 0.000000000000000000000000000000008493 133.0
HFD2_k127_6413810_9 Belongs to the UPF0251 family - - - 0.000000000000000000000000002339 120.0
HFD2_k127_646404_0 Belongs to the transketolase family K00615 - 2.2.1.1 3.378e-275 861.0
HFD2_k127_646404_1 Sugar (and other) transporter K03446 - - 1.173e-197 629.0
HFD2_k127_646404_2 HlyD membrane-fusion protein of T1SS K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 348.0
HFD2_k127_646404_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 346.0
HFD2_k127_646404_4 AMP binding - - - 0.0000000000000000000000000000000000003849 150.0
HFD2_k127_646404_5 Rubredoxin - - - 0.00000000000000000009783 91.0
HFD2_k127_6513240_0 TonB dependent receptor K02014 - - 2.08e-247 781.0
HFD2_k127_6513240_1 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000001436 201.0
HFD2_k127_6513240_2 - - - - 0.0000000000000000000000000000000000000000000000002491 190.0
HFD2_k127_6513240_3 Histidine kinase K07651 - 2.7.13.3 0.00000000000000000000000000000000000000000005155 182.0
HFD2_k127_6513240_4 Haloacid dehalogenase-like hydrolase K20866 - 3.1.3.10 0.00000000000000000000000000000458 127.0
HFD2_k127_6513240_5 energy transducer activity K03646,K03832 - - 0.0000000000000000000000004088 115.0
HFD2_k127_6513240_6 Predicted membrane protein (DUF2318) K09005 - - 0.00000000000000000005072 95.0
HFD2_k127_6513240_7 PFAM response regulator receiver - - - 0.00000000000007417 74.0
HFD2_k127_6532172_0 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000465 196.0
HFD2_k127_6532172_1 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000001613 160.0
HFD2_k127_6532172_2 Methyltransferase type 11 - - - 0.0000000000001026 82.0
HFD2_k127_6546847_0 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 3.637e-239 756.0
HFD2_k127_6546847_1 Ribosomal protein S1 K02945,K03527 - 1.17.7.4 6.583e-220 696.0
HFD2_k127_6546847_10 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001966 250.0
HFD2_k127_6546847_11 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000001182 241.0
HFD2_k127_6546847_12 PFAM Stage II sporulation K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000004175 245.0
HFD2_k127_6546847_13 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000006071 223.0
HFD2_k127_6546847_14 PFAM Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000002691 221.0
HFD2_k127_6546847_15 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000000000000000000000969 224.0
HFD2_k127_6546847_16 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000002153 156.0
HFD2_k127_6546847_17 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.0000000000000000000000000000000000000007792 149.0
HFD2_k127_6546847_18 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000001392 154.0
HFD2_k127_6546847_19 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000521 156.0
HFD2_k127_6546847_2 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 455.0
HFD2_k127_6546847_20 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000002129 137.0
HFD2_k127_6546847_21 bacterial (prokaryotic) histone like domain K05788 - - 0.00000000000000000000000000000000292 130.0
HFD2_k127_6546847_22 Protein of unknown function (DUF2905) - - - 0.00000000000000000008906 91.0
HFD2_k127_6546847_23 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000925 87.0
HFD2_k127_6546847_24 HEPN domain - - - 0.0000000265 61.0
HFD2_k127_6546847_26 Lipoprotein - - - 0.0003097 51.0
HFD2_k127_6546847_3 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 409.0
HFD2_k127_6546847_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 370.0
HFD2_k127_6546847_5 Ion transport 2 domain protein K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 351.0
HFD2_k127_6546847_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 340.0
HFD2_k127_6546847_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 306.0
HFD2_k127_6546847_8 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001166 281.0
HFD2_k127_6546847_9 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007399 260.0
HFD2_k127_6569569_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 493.0
HFD2_k127_6569569_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 331.0
HFD2_k127_6569569_2 Protein of unknown function (DUF401) K09133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 328.0
HFD2_k127_6569569_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000378 190.0
HFD2_k127_6569569_4 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000002629 177.0
HFD2_k127_6569569_5 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000007431 131.0
HFD2_k127_6569569_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000002495 118.0
HFD2_k127_6611120_0 Polysulphide reductase, NrfD - - - 2.062e-196 631.0
HFD2_k127_6611120_1 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 586.0
HFD2_k127_6611120_10 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.000000000000000000000000000000000000000000000000000000000000007566 219.0
HFD2_k127_6611120_11 PFAM Lytic transglycosylase catalytic K08309 - - 0.000000000000000000000000000000000000000000001537 173.0
HFD2_k127_6611120_12 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000005039 186.0
HFD2_k127_6611120_13 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000001174 177.0
HFD2_k127_6611120_14 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000006405 154.0
HFD2_k127_6611120_15 12 heme-binding sites - - - 0.0000000000000000000000000000000000000003278 164.0
HFD2_k127_6611120_16 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000486 160.0
HFD2_k127_6611120_17 von Willebrand factor (vWF) type D domain - - - 0.00000000000000000000000000000000000108 157.0
HFD2_k127_6611120_18 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000005178 143.0
HFD2_k127_6611120_19 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000002876 134.0
HFD2_k127_6611120_2 N-Acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 470.0
HFD2_k127_6611120_20 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000004559 137.0
HFD2_k127_6611120_21 PFAM Rubrerythrin - - - 0.00000008488 60.0
HFD2_k127_6611120_3 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 428.0
HFD2_k127_6611120_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 417.0
HFD2_k127_6611120_5 Family 5 K02035,K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 375.0
HFD2_k127_6611120_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 330.0
HFD2_k127_6611120_7 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 338.0
HFD2_k127_6611120_8 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 288.0
HFD2_k127_6611120_9 4Fe-4S ferredoxin K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003132 246.0
HFD2_k127_6619145_0 Cytochrome b/b6/petB K00412,K03888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 427.0
HFD2_k127_6619145_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 385.0
HFD2_k127_6619145_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000007706 264.0
HFD2_k127_6619145_3 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000135 167.0
HFD2_k127_6619145_4 4Fe-4S binding domain - - - 0.000000000003955 68.0
HFD2_k127_6619145_5 - - - - 0.000000003673 57.0
HFD2_k127_6620861_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 588.0
HFD2_k127_6620861_1 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 434.0
HFD2_k127_6620861_10 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000001584 89.0
HFD2_k127_6620861_11 Domain of unknown function (DUF4115) - - - 0.00000000000000004988 89.0
HFD2_k127_6620861_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 418.0
HFD2_k127_6620861_3 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 402.0
HFD2_k127_6620861_4 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 392.0
HFD2_k127_6620861_5 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001848 287.0
HFD2_k127_6620861_6 dUTPase K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000000000000001014 204.0
HFD2_k127_6620861_7 NUDIX domain K00077,K01092,K03574 - 1.1.1.169,3.1.3.25,3.6.1.55 0.00000000000000000000000000000000000000000000000009372 180.0
HFD2_k127_6620861_8 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000009793 179.0
HFD2_k127_6620861_9 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000005593 141.0
HFD2_k127_6766525_0 Dehydratase family K01687 - 4.2.1.9 6.761e-250 782.0
HFD2_k127_6766525_1 peptidase U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 582.0
HFD2_k127_6766525_10 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000001927 212.0
HFD2_k127_6766525_11 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000004937 188.0
HFD2_k127_6766525_12 negative regulation of translational initiation K05554,K15885 - - 0.00000000000000000000000000000000000000007271 156.0
HFD2_k127_6766525_13 Acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000003952 122.0
HFD2_k127_6766525_14 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000004469 69.0
HFD2_k127_6766525_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 561.0
HFD2_k127_6766525_3 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 535.0
HFD2_k127_6766525_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 464.0
HFD2_k127_6766525_5 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 346.0
HFD2_k127_6766525_6 ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 308.0
HFD2_k127_6766525_7 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001253 254.0
HFD2_k127_6766525_8 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004321 242.0
HFD2_k127_6766525_9 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000004593 235.0
HFD2_k127_6804783_0 Sigma-54 interaction domain - - - 4.581e-205 646.0
HFD2_k127_6804783_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 4.767e-204 653.0
HFD2_k127_6804783_10 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000004773 168.0
HFD2_k127_6804783_11 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000001641 157.0
HFD2_k127_6804783_12 - - - - 0.00000000000000000001223 93.0
HFD2_k127_6804783_2 membrane protein involved in D-alanine export K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 533.0
HFD2_k127_6804783_3 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 501.0
HFD2_k127_6804783_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 497.0
HFD2_k127_6804783_5 Histidine kinase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 342.0
HFD2_k127_6804783_6 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 334.0
HFD2_k127_6804783_7 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 302.0
HFD2_k127_6804783_8 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006884 280.0
HFD2_k127_6804783_9 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000003783 184.0
HFD2_k127_6871592_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 509.0
HFD2_k127_6871592_1 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 317.0
HFD2_k127_6871592_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 324.0
HFD2_k127_6871592_3 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001839 276.0
HFD2_k127_6871592_4 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000000000000000000002662 139.0
HFD2_k127_6871592_5 Polymer-forming cytoskeletal - - - 0.000000000000000000000006318 111.0
HFD2_k127_7057961_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 521.0
HFD2_k127_7057961_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 410.0
HFD2_k127_7057961_10 Yqey-like protein K09117 - - 0.0000000000000000000000000000000006663 134.0
HFD2_k127_7057961_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 377.0
HFD2_k127_7057961_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 319.0
HFD2_k127_7057961_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 295.0
HFD2_k127_7057961_5 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 300.0
HFD2_k127_7057961_6 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004624 274.0
HFD2_k127_7057961_7 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000003725 252.0
HFD2_k127_7057961_8 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000932 237.0
HFD2_k127_7057961_9 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000001871 188.0
HFD2_k127_7075274_0 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 332.0
HFD2_k127_7075274_1 ubiE/COQ5 methyltransferase family K15256 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 303.0
HFD2_k127_7075274_11 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000003651 166.0
HFD2_k127_7075274_12 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000004473 155.0
HFD2_k127_7075274_13 Family of unknown function (DUF5343) - - - 0.000000000000000000000000000000000004003 145.0
HFD2_k127_7075274_14 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000008808 142.0
HFD2_k127_7075274_15 - - - - 0.000000000000000000000000000005557 126.0
HFD2_k127_7075274_16 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000123 101.0
HFD2_k127_7075274_17 Fe-S oxidoreductase - - - 0.0000000000000006542 87.0
HFD2_k127_7075274_2 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 296.0
HFD2_k127_7075274_3 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000667 282.0
HFD2_k127_7075274_4 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008486 275.0
HFD2_k127_7075274_5 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002497 244.0
HFD2_k127_7075274_6 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000001212 208.0
HFD2_k127_7075274_7 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000004091 207.0
HFD2_k127_7075274_8 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000000000004071 199.0
HFD2_k127_7075274_9 methylamine metabolic process K15977 - - 0.0000000000000000000000000000000000000000000000000003846 187.0
HFD2_k127_7086350_0 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 443.0
HFD2_k127_7086350_1 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 427.0
HFD2_k127_7086350_2 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 345.0
HFD2_k127_7086350_3 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000165 275.0
HFD2_k127_7086350_4 Major facilitator Superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000217 265.0
HFD2_k127_7086350_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000485 228.0
HFD2_k127_7086350_6 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000001904 226.0
HFD2_k127_7086350_7 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000003706 178.0
HFD2_k127_7091471_0 Tryptophanyl-tRNA synthetase K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000009616 207.0
HFD2_k127_7091471_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000001414 128.0
HFD2_k127_7091471_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000009459 126.0
HFD2_k127_7091471_3 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000000002035 115.0
HFD2_k127_7092618_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 9.449e-214 675.0
HFD2_k127_7092618_1 elongation factor G K02355 - - 4.65e-211 687.0
HFD2_k127_7092618_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 380.0
HFD2_k127_7092618_11 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 377.0
HFD2_k127_7092618_12 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007787 352.0
HFD2_k127_7092618_13 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 357.0
HFD2_k127_7092618_14 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 335.0
HFD2_k127_7092618_15 MazG family K02428,K02499 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 298.0
HFD2_k127_7092618_16 PFAM response regulator receiver K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 294.0
HFD2_k127_7092618_17 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 295.0
HFD2_k127_7092618_18 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 286.0
HFD2_k127_7092618_19 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 283.0
HFD2_k127_7092618_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 607.0
HFD2_k127_7092618_20 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000001742 263.0
HFD2_k127_7092618_21 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000184 277.0
HFD2_k127_7092618_22 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003064 266.0
HFD2_k127_7092618_23 DNA polymerase alpha chain like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003269 262.0
HFD2_k127_7092618_24 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000007592 211.0
HFD2_k127_7092618_25 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000003154 208.0
HFD2_k127_7092618_26 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.00000000000000000000000000000000000000000000000000000008789 203.0
HFD2_k127_7092618_27 Ppx/GppA phosphatase family K01524 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000001803 194.0
HFD2_k127_7092618_28 Sensor histidine kinase, HAMP domain-containing K07644 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000179 195.0
HFD2_k127_7092618_29 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000379 188.0
HFD2_k127_7092618_3 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 445.0
HFD2_k127_7092618_30 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000000000000009742 181.0
HFD2_k127_7092618_31 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000001083 174.0
HFD2_k127_7092618_32 PFAM Cobinamide kinase cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000000000000000000003722 171.0
HFD2_k127_7092618_33 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000007639 162.0
HFD2_k127_7092618_34 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000001203 155.0
HFD2_k127_7092618_35 HEPN domain - - - 0.000000000000000000000000000000000000003725 149.0
HFD2_k127_7092618_36 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000002829 128.0
HFD2_k127_7092618_37 PTS system fructose IIA component K02793 - 2.7.1.191 0.00000000000000000000000000000009792 128.0
HFD2_k127_7092618_38 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000001019 119.0
HFD2_k127_7092618_39 phosphocarrier protein HPr K11189 - - 0.0000000000000000000000003239 107.0
HFD2_k127_7092618_4 Hydrogenase expression formation protein hypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 441.0
HFD2_k127_7092618_40 Regulatory protein - - - 0.0000000000000000000005461 102.0
HFD2_k127_7092618_41 PilZ domain - - - 0.000000000000000000001231 100.0
HFD2_k127_7092618_42 PFAM DNA polymerase beta domain protein region - - - 0.000000000000000005895 87.0
HFD2_k127_7092618_43 Type II secretion system (T2SS), protein E, N-terminal domain K02652 - - 0.000000000000000006244 93.0
HFD2_k127_7092618_44 - - - - 0.00000000000000002964 89.0
HFD2_k127_7092618_45 HupF/HypC family K04653 - - 0.00000000000000005256 84.0
HFD2_k127_7092618_46 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000001126 95.0
HFD2_k127_7092618_47 OstA-like protein K09774 - - 0.0000000000000001683 87.0
HFD2_k127_7092618_48 Protein conserved in bacteria K11719 - - 0.00000000000001282 81.0
HFD2_k127_7092618_49 cell envelope organization K05807,K08309 - - 0.0000000000035 78.0
HFD2_k127_7092618_5 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 442.0
HFD2_k127_7092618_50 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.0000000009447 65.0
HFD2_k127_7092618_51 - - - - 0.000000009923 59.0
HFD2_k127_7092618_52 - - - - 0.000004933 49.0
HFD2_k127_7092618_53 ABC transporter (Permease) K01992 - - 0.00001786 56.0
HFD2_k127_7092618_54 PFAM PEGA domain - - - 0.0000471 53.0
HFD2_k127_7092618_55 - - - - 0.00008874 46.0
HFD2_k127_7092618_56 Protein tyrosine kinase - - - 0.0001062 51.0
HFD2_k127_7092618_58 dehydrogenase - - - 0.0008996 43.0
HFD2_k127_7092618_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 416.0
HFD2_k127_7092618_7 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 401.0
HFD2_k127_7092618_8 7TM-HD extracellular K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 405.0
HFD2_k127_7092618_9 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 383.0
HFD2_k127_709474_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 555.0
HFD2_k127_709474_1 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000009732 246.0
HFD2_k127_709474_2 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000000000000000006823 211.0
HFD2_k127_709474_3 outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000004512 71.0
HFD2_k127_709474_4 Orn Lys Arg decarboxylase major K01585 - 4.1.1.19 0.00000001929 56.0
HFD2_k127_7115290_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.207e-297 949.0
HFD2_k127_7115290_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 2.711e-213 676.0
HFD2_k127_7115290_10 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000000000000000000000000000005864 154.0
HFD2_k127_7115290_11 PFAM Cupin domain - - - 0.0000000000000000000000000000000000001617 150.0
HFD2_k127_7115290_12 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K03769,K07533 - 5.2.1.8 0.0000000000000000000000002754 113.0
HFD2_k127_7115290_13 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000008563 94.0
HFD2_k127_7115290_14 S4 domain protein - - - 0.000000000000000006975 87.0
HFD2_k127_7115290_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000755 404.0
HFD2_k127_7115290_3 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 405.0
HFD2_k127_7115290_4 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 331.0
HFD2_k127_7115290_5 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000003749 257.0
HFD2_k127_7115290_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000000000001666 203.0
HFD2_k127_7115290_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000005776 206.0
HFD2_k127_7115290_8 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000003772 189.0
HFD2_k127_7115290_9 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271,K12961 - 5.3.1.28 0.000000000000000000000000000000000000000000031 168.0
HFD2_k127_7141763_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0 1202.0
HFD2_k127_7141763_1 NADH-quinone oxidoreductase K00341 - 1.6.5.3 3.045e-213 679.0
HFD2_k127_7141763_10 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000002955 137.0
HFD2_k127_7141763_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000008365 121.0
HFD2_k127_7141763_2 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336,K05299 - 1.17.1.10,1.6.5.3 2.305e-211 686.0
HFD2_k127_7141763_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 584.0
HFD2_k127_7141763_4 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 503.0
HFD2_k127_7141763_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 480.0
HFD2_k127_7141763_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 394.0
HFD2_k127_7141763_7 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006153 263.0
HFD2_k127_7141763_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000009779 152.0
HFD2_k127_7141763_9 Ferric uptake regulator family K22297 - - 0.000000000000000000000000000000000003668 138.0
HFD2_k127_7144565_0 Patatin-like phospholipase K07001 - - 3.476e-198 627.0
HFD2_k127_7144565_1 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 363.0
HFD2_k127_7144565_2 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007443 344.0
HFD2_k127_7144565_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002601 270.0
HFD2_k127_7144565_4 Iron-sulfur cluster-binding domain K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000002843 229.0
HFD2_k127_7144565_5 Protein of unknown function (DUF3313) - - - 0.00000000000000000000000000000000000000000000000000000004427 203.0
HFD2_k127_7144565_6 - - - - 0.00000000000000000000000000000000000000000001035 177.0
HFD2_k127_7144565_7 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000000000001432 117.0
HFD2_k127_7144565_8 Putative MetA-pathway of phenol degradation - - - 0.000000000000003716 78.0
HFD2_k127_7144565_9 belongs to the glycosyl hydrolase 13 family K01176,K01208 GO:0005575,GO:0005576 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000007674 85.0
HFD2_k127_7162585_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.212e-279 869.0
HFD2_k127_7162585_1 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008064 279.0
HFD2_k127_7162585_2 Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily K02825 - 2.4.2.9 0.000000000000000000000000000000000000005518 147.0
HFD2_k127_7162585_3 ROK family K00845 - 2.7.1.2 0.000000000000000000007077 95.0
HFD2_k127_7188907_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.939e-195 628.0
HFD2_k127_7188907_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 351.0
HFD2_k127_7188907_2 PFAM iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000000000000006802 210.0
HFD2_k127_7204391_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 387.0
HFD2_k127_7204391_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000466 242.0
HFD2_k127_7204391_10 COG2202 FOG PAS PAC domain - - - 0.0000000000000000508 95.0
HFD2_k127_7204391_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443,K16786,K16787 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000001831 210.0
HFD2_k127_7204391_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000009692 208.0
HFD2_k127_7204391_4 GAF domain - - - 0.00000000000000000000000000000000000000000000000009186 192.0
HFD2_k127_7204391_5 Chromate transporter K07240 - - 0.000000000000000000000000000000007169 134.0
HFD2_k127_7204391_6 Chromate transport protein K07240 - - 0.000000000000000000000000000004139 127.0
HFD2_k127_7204391_7 TIGRFAM thioredoxin K03672 - 1.8.1.8 0.00000000000000000000000001412 113.0
HFD2_k127_7204391_8 Universal stress protein - - - 0.000000000000000000008264 103.0
HFD2_k127_7204391_9 Nitrous oxide-stimulated promoter - - - 0.0000000000000000003437 88.0
HFD2_k127_7214206_0 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 5.82e-255 810.0
HFD2_k127_7214206_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 7.945e-241 767.0
HFD2_k127_7214206_10 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000008064 229.0
HFD2_k127_7214206_11 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000935 213.0
HFD2_k127_7214206_12 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000001251 217.0
HFD2_k127_7214206_13 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000001315 197.0
HFD2_k127_7214206_14 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000003676 181.0
HFD2_k127_7214206_15 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000004583 148.0
HFD2_k127_7214206_16 repeat-containing protein - - - 0.000000000000000000000000000003073 134.0
HFD2_k127_7214206_17 Pilus assembly protein K02662 - - 0.000000000000000000000000003326 123.0
HFD2_k127_7214206_18 Glycosyl transferase family 41 - - - 0.0000000000000000000000003175 119.0
HFD2_k127_7214206_19 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000006029 101.0
HFD2_k127_7214206_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.872e-227 728.0
HFD2_k127_7214206_20 Domain of unknown function (DUF1858) - - - 0.0000000000000001544 83.0
HFD2_k127_7214206_22 PFAM Fimbrial assembly family protein K02461,K02662,K02663,K12289 - - 0.00004962 53.0
HFD2_k127_7214206_23 - K02664 - - 0.0003404 52.0
HFD2_k127_7214206_3 General secretory system II, protein E domain protein K02652 - - 3.959e-216 692.0
HFD2_k127_7214206_4 PFAM UvrD REP helicase K03657 - 3.6.4.12 6.37e-202 651.0
HFD2_k127_7214206_5 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 519.0
HFD2_k127_7214206_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 466.0
HFD2_k127_7214206_7 type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 442.0
HFD2_k127_7214206_8 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 334.0
HFD2_k127_7214206_9 PFAM PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004001 258.0
HFD2_k127_7236414_0 Acyl-CoA synthetase (NDP forming) K09181 - - 3.898e-226 720.0
HFD2_k127_7236414_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 400.0
HFD2_k127_7236414_10 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005778 248.0
HFD2_k127_7236414_11 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001146 255.0
HFD2_k127_7236414_12 PFAM ApbE family K09740 - - 0.00000000000000000000000000000000000000000000000000000001919 202.0
HFD2_k127_7236414_13 Response regulator receiver domain K03413 - - 0.00000000000000000000000000000000000000000000001908 173.0
HFD2_k127_7236414_14 Transcriptional regulator K13643 - - 0.000000000000000000000000000000000000002362 152.0
HFD2_k127_7236414_15 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000004531 149.0
HFD2_k127_7236414_16 Domain of unknown function (DUF3786) - - - 0.0000000000000000000000000007258 121.0
HFD2_k127_7236414_17 - - - - 0.00000000000000000000000002946 123.0
HFD2_k127_7236414_18 Protein of unknown function (DUF507) - - - 0.000000000000000001125 91.0
HFD2_k127_7236414_19 Protein of unknown function (DUF507) K09804 - - 0.0000000000001316 74.0
HFD2_k127_7236414_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 370.0
HFD2_k127_7236414_20 PFAM formylmethanofuran dehydrogenase subunit E K11261 - 1.2.7.12 0.000000000002498 75.0
HFD2_k127_7236414_21 - - - - 0.00009933 52.0
HFD2_k127_7236414_3 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 349.0
HFD2_k127_7236414_4 Transcriptional regulator K11921,K19338 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 337.0
HFD2_k127_7236414_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 323.0
HFD2_k127_7236414_6 DRTGG domain protein K06873 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 304.0
HFD2_k127_7236414_7 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001343 300.0
HFD2_k127_7236414_8 response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003644 304.0
HFD2_k127_7236414_9 HEAT repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000122 272.0
HFD2_k127_7337364_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 2.999e-197 622.0
HFD2_k127_7337364_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 385.0
HFD2_k127_7337364_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 300.0
HFD2_k127_7337364_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005659 291.0
HFD2_k127_7337364_4 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000003665 220.0
HFD2_k127_7337364_5 LysM domain - - - 0.000000000000000000000000000000000000000000000000000001584 199.0
HFD2_k127_7337364_6 NHL repeat - - - 0.0000000000000000000000000000000000000004 168.0
HFD2_k127_7337364_7 Serine threonine protein kinase - - - 0.000000000009607 78.0
HFD2_k127_7337364_9 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000001031 61.0
HFD2_k127_7339519_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 5.763e-245 775.0
HFD2_k127_7339519_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 572.0
HFD2_k127_7339519_10 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000000000000000001708 186.0
HFD2_k127_7339519_11 Histidine kinase - - - 0.000000000000000000000000000000000000000000000002401 194.0
HFD2_k127_7339519_12 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000005579 189.0
HFD2_k127_7339519_13 Domain of unknown function (DUF296) - - - 0.000000000000000000000000000000000001161 144.0
HFD2_k127_7339519_14 energy transducer activity K03832 - - 0.0000000000000000000000001114 117.0
HFD2_k127_7339519_15 phosphorelay signal transduction system - - - 0.0000000000000000000000006774 112.0
HFD2_k127_7339519_16 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K11686,K13640,K18997 - - 0.0000000000000008983 78.0
HFD2_k127_7339519_17 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.00000000000004765 74.0
HFD2_k127_7339519_18 Pilus assembly protein, PilP K02665 - - 0.00000000000006856 82.0
HFD2_k127_7339519_19 Pilus assembly protein PilO K02664 - - 0.000002143 57.0
HFD2_k127_7339519_2 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 492.0
HFD2_k127_7339519_20 PFAM Fimbrial assembly K02663 - - 0.000003165 57.0
HFD2_k127_7339519_21 Secretin and TonB N terminus short domain K02666 - - 0.00004309 55.0
HFD2_k127_7339519_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 384.0
HFD2_k127_7339519_4 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 344.0
HFD2_k127_7339519_5 pilus assembly protein K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 341.0
HFD2_k127_7339519_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 327.0
HFD2_k127_7339519_7 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 305.0
HFD2_k127_7339519_8 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004871 279.0
HFD2_k127_7339519_9 Phosphate sensor histidine kinase, HAMP and PAS domain-containing K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000002526 223.0
HFD2_k127_7356472_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.55e-208 654.0
HFD2_k127_7356472_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 549.0
HFD2_k127_7356472_2 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 548.0
HFD2_k127_7356472_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007008 519.0
HFD2_k127_7356472_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009629 509.0
HFD2_k127_7356472_5 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001137 259.0
HFD2_k127_7356472_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000007453 261.0
HFD2_k127_7356472_7 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000002321 162.0
HFD2_k127_7356472_8 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000001212 68.0
HFD2_k127_7356472_9 periplasmic ligand-binding sensor domain - - - 0.000008247 51.0
HFD2_k127_7390782_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 5.845e-196 622.0
HFD2_k127_7390782_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 452.0
HFD2_k127_7390782_2 amine dehydrogenase activity K01179,K03333,K12287 - 1.1.3.6,3.2.1.4 0.00000000000000000962 90.0
HFD2_k127_7390782_3 GlcNAc-PI de-N-acetylase - - - 0.00002655 53.0
HFD2_k127_7401745_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 4.923e-206 653.0
HFD2_k127_7401745_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 337.0
HFD2_k127_7401745_2 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008323 282.0
HFD2_k127_7401745_3 oxidoreductase activity K07114 - - 0.000000000000000000000000000000000000000000000000000000000000002255 230.0
HFD2_k127_7401745_4 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000003524 204.0
HFD2_k127_7401745_5 Von Willebrand factor type A domain K07114 - - 0.00000000000000000000000005554 123.0
HFD2_k127_7401745_6 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000008123 89.0
HFD2_k127_7401745_7 Tetratricopeptide repeat - - - 0.0000000000002599 81.0
HFD2_k127_7401745_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000002705 58.0
HFD2_k127_7438952_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 3.124e-205 655.0
HFD2_k127_7438952_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 376.0
HFD2_k127_7438952_2 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 313.0
HFD2_k127_7441972_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 356.0
HFD2_k127_7441972_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 323.0
HFD2_k127_7441972_2 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.00000000000000000000000000000000000000000001741 168.0
HFD2_k127_7454615_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 383.0
HFD2_k127_7454615_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 370.0
HFD2_k127_7482956_0 membrane transporter protein K07090 - - 2.154e-202 638.0
HFD2_k127_7482956_1 phosphorelay signal transduction system K02584,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003727 260.0
HFD2_k127_7482956_2 DNA-binding transcription factor activity K03710 - - 0.0000000000000000000000000000000004811 141.0
HFD2_k127_7482956_3 - - - - 0.00000000000000218 78.0
HFD2_k127_7632714_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 411.0
HFD2_k127_7632714_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000008378 255.0
HFD2_k127_7632714_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000006471 181.0
HFD2_k127_7632714_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000009139 133.0
HFD2_k127_7632714_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000001416 138.0
HFD2_k127_7632714_5 PAS domain - - - 0.00000000002629 70.0
HFD2_k127_7661773_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 8.524e-208 657.0
HFD2_k127_7661773_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 371.0
HFD2_k127_7661773_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 350.0
HFD2_k127_7661773_3 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 335.0
HFD2_k127_7661773_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000331 252.0
HFD2_k127_7661773_5 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000363 230.0
HFD2_k127_7661773_6 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000002086 205.0
HFD2_k127_7661773_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.00000000000000000000000000000000000001514 150.0
HFD2_k127_7661773_8 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.0000000000000000000000000000000009077 135.0
HFD2_k127_7661773_9 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000007534 136.0
HFD2_k127_7678018_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 1.562e-232 732.0
HFD2_k127_7678018_1 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 3.623e-194 629.0
HFD2_k127_7678018_10 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 316.0
HFD2_k127_7678018_11 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009438 308.0
HFD2_k127_7678018_12 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001379 278.0
HFD2_k127_7678018_13 Signal transduction histidine kinase, nitrogen specific, NtrB K07708,K10942 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000082 277.0
HFD2_k127_7678018_14 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000006665 248.0
HFD2_k127_7678018_15 Carotenoid biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000006798 230.0
HFD2_k127_7678018_16 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000103 201.0
HFD2_k127_7678018_18 thiolester hydrolase activity K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000008442 178.0
HFD2_k127_7678018_19 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.000000000000000000000000000000000000000000007449 171.0
HFD2_k127_7678018_2 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 605.0
HFD2_k127_7678018_20 Zincin-like metallopeptidase - - - 0.00000000000000000000000004479 113.0
HFD2_k127_7678018_21 Cell surface protein - - - 0.00000000000000000005768 106.0
HFD2_k127_7678018_22 - - - - 0.00000000000000000007308 96.0
HFD2_k127_7678018_23 - - - - 0.00000000000000009872 84.0
HFD2_k127_7678018_24 His Kinase A (phosphoacceptor) domain - - - 0.0000000000001149 83.0
HFD2_k127_7678018_25 - - - - 0.0000000000003555 75.0
HFD2_k127_7678018_26 Transcriptional regulatory protein, C terminal K07658 - - 0.000000005474 68.0
HFD2_k127_7678018_27 P-type ATPase K17686 - 3.6.3.54 0.00000006804 55.0
HFD2_k127_7678018_28 - - - - 0.000006318 60.0
HFD2_k127_7678018_3 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 529.0
HFD2_k127_7678018_4 Glutamine amidotransferases class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 486.0
HFD2_k127_7678018_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 485.0
HFD2_k127_7678018_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 473.0
HFD2_k127_7678018_7 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008396 419.0
HFD2_k127_7678018_8 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000758 404.0
HFD2_k127_7678018_9 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 391.0
HFD2_k127_7692055_0 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000784 282.0
HFD2_k127_7692055_1 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000007298 252.0
HFD2_k127_7692055_2 transferase activity, transferring glycosyl groups K02844 - - 0.0000000000000000000000000000000000000000000000000000000000001334 228.0
HFD2_k127_7898628_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 7.455e-245 772.0
HFD2_k127_7898628_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 308.0
HFD2_k127_7898628_2 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000001375 257.0
HFD2_k127_7898628_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000511 238.0
HFD2_k127_7898628_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000003668 138.0
HFD2_k127_7898628_5 Ribosome-binding factor A K02834 - - 0.0000000000000000000000000000001572 126.0
HFD2_k127_7898628_6 Protein of unknown function (DUF503) K09764 - - 0.000000000000000001569 91.0
HFD2_k127_7902418_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 6.912e-272 861.0
HFD2_k127_7902418_1 This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation K02591 - 1.18.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 553.0
HFD2_k127_7902418_2 PFAM Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006186 272.0
HFD2_k127_7902418_3 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001668 252.0
HFD2_k127_7902418_4 NifQ K15790 - - 0.00000000000000000000000000000000000000002265 155.0
HFD2_k127_7902418_5 Nitrogen regulatory protein P-II K02589 - - 0.0000000000000000000000000000000000000008258 156.0
HFD2_k127_7902418_6 Dinitrogenase iron-molybdenum cofactor K02596 - - 0.000000000000000000000000000000000000003815 150.0
HFD2_k127_7902418_7 Nitrogen regulatory protein P-II K02590 - - 0.000000000000000000000000000000001143 136.0
HFD2_k127_7902418_8 4Fe-4S binding domain - - - 0.00000000000000000000000003724 111.0
HFD2_k127_7902418_9 abc transporter K02017 - 3.6.3.29 0.00000000002255 68.0
HFD2_k127_7905650_0 HELICc2 K03722 - 3.6.4.12 1.378e-241 772.0
HFD2_k127_7905650_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 432.0
HFD2_k127_7905650_10 Cupredoxin-like domain - - - 0.000000000000000000003839 93.0
HFD2_k127_7905650_11 Psort location CytoplasmicMembrane, score - - - 0.0000000006619 70.0
HFD2_k127_7905650_12 Colicin V production protein K03558 - - 0.000003071 58.0
HFD2_k127_7905650_2 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 422.0
HFD2_k127_7905650_3 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 418.0
HFD2_k127_7905650_4 PFAM Transketolase central region K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 401.0
HFD2_k127_7905650_5 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 362.0
HFD2_k127_7905650_6 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 336.0
HFD2_k127_7905650_7 PFAM OsmC family protein K04063 - - 0.000000000000000000000000000000000000000000000000000001091 194.0
HFD2_k127_7905650_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000003986 193.0
HFD2_k127_7905650_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000006816 179.0
HFD2_k127_7911326_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 5.378e-287 902.0
HFD2_k127_7911326_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 369.0
HFD2_k127_7911326_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 324.0
HFD2_k127_7911326_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 304.0
HFD2_k127_7911326_4 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000006504 158.0
HFD2_k127_7911326_5 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000002948 95.0
HFD2_k127_7911326_6 Belongs to the glycosyl hydrolase family 6 K01183 - 3.2.1.14 0.00000000003908 73.0
HFD2_k127_7924933_0 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007114 402.0
HFD2_k127_7924933_1 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 387.0
HFD2_k127_7924933_10 GYD family - - - 0.000000000000000001203 90.0
HFD2_k127_7924933_12 PFAM cobalamin (vitamin B12) biosynthesis CbiM K02007 - - 0.000000000000001573 77.0
HFD2_k127_7924933_13 Uncharacterized conserved protein (DUF2304) K09153 - - 0.000000000983 62.0
HFD2_k127_7924933_14 Bacterial protein of unknown function (Gcw_chp) - - - 0.0002529 53.0
HFD2_k127_7924933_2 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 321.0
HFD2_k127_7924933_3 Cytochrome b/b6/petB K03887 - - 0.000000000000000000000000000000000000000000000000000000000000000000005213 242.0
HFD2_k127_7924933_4 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000005004 228.0
HFD2_k127_7924933_5 helix_turn_helix, Lux Regulon K02282 - - 0.0000000000000000000000000000000000000000000000000000000000001088 218.0
HFD2_k127_7924933_6 ferrous iron binding K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000003142 212.0
HFD2_k127_7924933_7 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000002585 201.0
HFD2_k127_7924933_8 nickel-responsive regulator K07722 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000001033 183.0
HFD2_k127_7924933_9 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000001401 111.0
HFD2_k127_7934028_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 579.0
HFD2_k127_7934028_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 420.0
HFD2_k127_7934028_2 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 384.0
HFD2_k127_7934028_3 PFAM Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 320.0
HFD2_k127_7934028_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000003443 259.0
HFD2_k127_7934028_5 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000009341 186.0
HFD2_k127_7934028_6 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000002035 143.0
HFD2_k127_7934028_7 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000001244 98.0
HFD2_k127_7934028_8 structural constituent of ribosome K02911 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000001131 83.0
HFD2_k127_7976352_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 6.383e-294 923.0
HFD2_k127_7976352_1 Flavin containing amine oxidoreductase - - - 1.55e-222 700.0
HFD2_k127_7976352_11 HEAT repeat - - - 0.00000001057 66.0
HFD2_k127_7976352_12 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000003901 66.0
HFD2_k127_7976352_13 Uncharacterized protein conserved in bacteria (DUF2135) - - - 0.0000004024 64.0
HFD2_k127_7976352_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 506.0
HFD2_k127_7976352_3 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008538 374.0
HFD2_k127_7976352_4 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001166 281.0
HFD2_k127_7976352_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000004684 229.0
HFD2_k127_7976352_6 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000001083 197.0
HFD2_k127_7976352_7 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000001338 191.0
HFD2_k127_7976352_8 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000002524 176.0
HFD2_k127_7976352_9 PFAM UvrB UvrC protein K08999,K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.00000000000000000000003318 116.0
HFD2_k127_7982323_0 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 511.0
HFD2_k127_7982323_1 TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 413.0
HFD2_k127_7982323_2 Ankyrin repeat K15502,K15503,K15504 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006810,GO:0006888,GO:0006900,GO:0006901,GO:0006903,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016050,GO:0016192,GO:0022607,GO:0031974,GO:0031981,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046907,GO:0048193,GO:0048194,GO:0048199,GO:0048207,GO:0048208,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0061024,GO:0065003,GO:0070013,GO:0071840,GO:0090114 - 0.00000000000000000000000000000000000000000000000000003223 207.0
HFD2_k127_7982323_3 response regulator - - - 0.0000000000000000000000000000000000002101 156.0
HFD2_k127_7982323_4 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000408 129.0
HFD2_k127_7982323_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000003421 118.0
HFD2_k127_7982323_6 PFAM ApbE family K09740 - - 0.0000000000000397 75.0
HFD2_k127_7982323_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000006859 59.0
HFD2_k127_7982323_8 Prenyltransferase UbiA - - - 0.00007066 46.0
HFD2_k127_8010278_0 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 357.0
HFD2_k127_8010278_1 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 346.0
HFD2_k127_8010278_10 cytochrome C biogenesis protein ResB K07399 - - 0.000000000000000001668 100.0
HFD2_k127_8010278_11 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000968 82.0
HFD2_k127_8010278_12 Phosphate-starvation-inducible E - - - 0.00000000003844 70.0
HFD2_k127_8010278_13 Predicted RNA-binding protein - - - 0.0000000001744 63.0
HFD2_k127_8010278_2 ATPases associated with a variety of cellular activities K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 300.0
HFD2_k127_8010278_3 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005316 281.0
HFD2_k127_8010278_4 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001929 262.0
HFD2_k127_8010278_5 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000008902 178.0
HFD2_k127_8010278_6 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000002599 152.0
HFD2_k127_8010278_7 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000007638 139.0
HFD2_k127_8010278_8 PFAM Cobalt transport protein K02008 - - 0.00000000000000000000000000001133 128.0
HFD2_k127_8010278_9 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000002131 116.0
HFD2_k127_8023912_0 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 2.051e-204 646.0
HFD2_k127_8023912_1 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 1.341e-200 645.0
HFD2_k127_8023912_2 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 555.0
HFD2_k127_8023912_3 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000009403 257.0
HFD2_k127_8023912_4 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000008605 228.0
HFD2_k127_8023912_5 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000000000000000000002234 227.0
HFD2_k127_8023912_6 Thiol disulfide interchange protein K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000006778 167.0
HFD2_k127_8023912_7 coenzyme binding K07071 - - 0.000000000000000000000004404 113.0
HFD2_k127_8023912_8 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.00000000000000000001208 96.0
HFD2_k127_8047511_0 Protein involved in outer membrane biogenesis - - - 1.453e-244 797.0
HFD2_k127_8047511_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 559.0
HFD2_k127_8047511_10 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000000000000000004947 130.0
HFD2_k127_8047511_11 copG family - - - 0.00000000000000000000002575 101.0
HFD2_k127_8047511_12 Cold-shock protein K03704 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000001576 98.0
HFD2_k127_8047511_13 Helix-hairpin-helix motif - - - 0.000000000000000000002689 99.0
HFD2_k127_8047511_14 PilZ domain - - - 0.000000000004779 71.0
HFD2_k127_8047511_16 Polyketide cyclase / dehydrase and lipid transport K05554 - - 0.000706 49.0
HFD2_k127_8047511_2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 422.0
HFD2_k127_8047511_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 389.0
HFD2_k127_8047511_4 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004746 368.0
HFD2_k127_8047511_5 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 313.0
HFD2_k127_8047511_6 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000000000005267 205.0
HFD2_k127_8047511_8 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000006338 177.0
HFD2_k127_8047511_9 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000000000000008518 132.0
HFD2_k127_8054082_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0 1153.0
HFD2_k127_8054082_1 Large extracellular alpha-helical protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 470.0
HFD2_k127_8054082_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 379.0
HFD2_k127_8054082_3 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 306.0
HFD2_k127_8054082_4 Catalyzes the reduction of arsenate As(V) to arsenite As(III) K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000001281 178.0
HFD2_k127_8054082_5 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000001141 176.0
HFD2_k127_8054082_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000008141 134.0
HFD2_k127_8054082_7 4Fe-4S binding domain - - - 0.00000000000000000000000000000005809 133.0
HFD2_k127_8054082_8 Transcriptional regulator K13640 - - 0.00000000000000000000000000001804 120.0
HFD2_k127_8084350_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.524e-226 723.0
HFD2_k127_8084350_1 binding domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 331.0
HFD2_k127_8084350_2 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000001031 176.0
HFD2_k127_8084350_3 helix_turn_helix multiple antibiotic resistance protein K06075 - - 0.000000000000000000000000000000000000001497 151.0
HFD2_k127_8084350_5 cytochrome c biogenesis protein K07399 - - 0.000000001101 65.0
HFD2_k127_8084350_6 Thioredoxin - - - 0.00000002801 60.0
HFD2_k127_8091292_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005479 402.0
HFD2_k127_8091292_1 Ribosomal protein L3 K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001668 247.0
HFD2_k127_8091292_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000008954 224.0
HFD2_k127_8091292_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000000000000000000000000000000000002033 206.0
HFD2_k127_8091292_4 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000006708 220.0
HFD2_k127_8091292_5 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000005104 179.0
HFD2_k127_8091292_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000007915 141.0
HFD2_k127_8091292_7 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000001316 139.0
HFD2_k127_8091292_8 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000006383 113.0
HFD2_k127_8119854_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 546.0
HFD2_k127_8119854_1 glycosyl transferase family 2 K21349 - 2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 544.0
HFD2_k127_8119854_10 - - - - 0.000000000000000000001534 102.0
HFD2_k127_8119854_11 DsrE/DsrF-like family - - - 0.00000000002082 70.0
HFD2_k127_8119854_12 PFAM Roadblock LC7 family protein - - - 0.0000000001173 63.0
HFD2_k127_8119854_2 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 396.0
HFD2_k127_8119854_3 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 345.0
HFD2_k127_8119854_4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008292 324.0
HFD2_k127_8119854_5 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000001133 269.0
HFD2_k127_8119854_6 transmembrane transport - - - 0.0000000000000000000000000000000000000000001392 168.0
HFD2_k127_8119854_7 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000001849 154.0
HFD2_k127_8119854_9 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000003103 109.0
HFD2_k127_8126206_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.393e-197 623.0
HFD2_k127_8126206_1 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008736 575.0
HFD2_k127_8126206_10 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000005234 194.0
HFD2_k127_8126206_11 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000008456 151.0
HFD2_k127_8126206_12 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000004047 157.0
HFD2_k127_8126206_13 ECF sigma factor K03088 - - 0.0000000000000000000000000000000001259 141.0
HFD2_k127_8126206_14 Thiamine-binding protein - - - 0.000000000000000000000000000000003239 131.0
HFD2_k127_8126206_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000006178 132.0
HFD2_k127_8126206_16 Protein of unknown function (DUF3106) - - - 0.0000000003982 71.0
HFD2_k127_8126206_18 Protein involved in outer membrane biogenesis - - - 0.0000001167 63.0
HFD2_k127_8126206_19 Putative zinc-finger - - - 0.000008735 54.0
HFD2_k127_8126206_2 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 509.0
HFD2_k127_8126206_3 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 496.0
HFD2_k127_8126206_4 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 476.0
HFD2_k127_8126206_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 382.0
HFD2_k127_8126206_6 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 387.0
HFD2_k127_8126206_7 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 301.0
HFD2_k127_8126206_8 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000001998 209.0
HFD2_k127_8126206_9 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000000000000000000000000001346 196.0
HFD2_k127_8263521_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 579.0
HFD2_k127_8263521_1 SMART Nucleotide binding protein, PINc K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008914 549.0
HFD2_k127_8263521_10 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000003821 235.0
HFD2_k127_8263521_11 PFAM YeeE YedE family (DUF395) K07112 - - 0.000000000000000000000000000000000000000000000000000000000000001093 231.0
HFD2_k127_8263521_12 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000002385 205.0
HFD2_k127_8263521_13 Transcriptional regulator, MerR family - - - 0.000000000000000000000000000000000007574 140.0
HFD2_k127_8263521_14 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000002268 137.0
HFD2_k127_8263521_16 Protein of unknown function (DUF3467) - - - 0.00000000000000000009652 93.0
HFD2_k127_8263521_17 Trypsin - - - 0.00000000000000001201 93.0
HFD2_k127_8263521_19 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000004708 69.0
HFD2_k127_8263521_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 473.0
HFD2_k127_8263521_20 Protein of unknown function (DUF1018) - - - 0.00000000006922 68.0
HFD2_k127_8263521_22 Domain of unknown function (DUF4418) - - - 0.000000009261 61.0
HFD2_k127_8263521_23 amine dehydrogenase activity - - - 0.000003128 59.0
HFD2_k127_8263521_24 Protein of unknown function (DUF3343) - - - 0.000004904 51.0
HFD2_k127_8263521_25 Belongs to the HesB IscA family - - - 0.000007932 53.0
HFD2_k127_8263521_3 TIGRFAM cysteine desulfurase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 424.0
HFD2_k127_8263521_4 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 368.0
HFD2_k127_8263521_5 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 349.0
HFD2_k127_8263521_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 341.0
HFD2_k127_8263521_7 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 336.0
HFD2_k127_8263521_8 PFAM cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 292.0
HFD2_k127_8263521_9 Efflux ABC transporter, permease protein K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000002141 250.0
HFD2_k127_8267032_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.092e-204 649.0
HFD2_k127_8267032_1 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 375.0
HFD2_k127_8267032_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 320.0
HFD2_k127_8267032_3 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000001327 240.0
HFD2_k127_8267032_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000005032 179.0
HFD2_k127_8267032_5 Utp--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000306 130.0
HFD2_k127_8267032_6 PFAM Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000002234 105.0
HFD2_k127_8267032_7 Transport permease protein K01992 - - 0.00000000000000000000006117 109.0
HFD2_k127_8272281_0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 5.335e-199 641.0
HFD2_k127_8272281_1 plastoquinone (Complex I) K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 537.0
HFD2_k127_8272281_10 PFAM Tetratricopeptide repeat - - - 0.000000004337 66.0
HFD2_k127_8272281_11 Class III cytochrome C family - - - 0.00002741 48.0
HFD2_k127_8272281_2 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 526.0
HFD2_k127_8272281_3 glycosyl hydrolase, BNR repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 374.0
HFD2_k127_8272281_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 340.0
HFD2_k127_8272281_5 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 344.0
HFD2_k127_8272281_6 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000003768 236.0
HFD2_k127_8272281_7 hydrogenase 4 membrane K12140 - - 0.000000000000000000000000000000000000000000000000000001546 198.0
HFD2_k127_8272281_8 O-methyltransferase activity K00588 - 2.1.1.104 0.00000000000000000000000000000000002431 143.0
HFD2_k127_8272281_9 Fungal family of unknown function (DUF1776) - - - 0.00000000000000000000000000001003 128.0
HFD2_k127_8405212_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1356.0
HFD2_k127_8405212_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 378.0
HFD2_k127_8405212_2 galactose-1-phosphate K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 337.0
HFD2_k127_8405212_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 336.0
HFD2_k127_8405212_4 electron transport complex, RnfABCDGE type, B subunit K03616 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 288.0
HFD2_k127_8405212_5 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008656 246.0
HFD2_k127_8405212_6 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000009847 220.0
HFD2_k127_8609466_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 1.965e-253 805.0
HFD2_k127_8609466_1 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 548.0
HFD2_k127_8609466_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000001197 144.0
HFD2_k127_8609466_11 metal-dependent phosphohydrolase HD sub domain - - - 0.00000000000000000000000000000000002596 151.0
HFD2_k127_8609466_12 NADPH-dependent FMN reductase - - - 0.0000000000000000000006605 99.0
HFD2_k127_8609466_13 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000000006258 92.0
HFD2_k127_8609466_14 SMART phosphoesterase PHP domain protein - - - 0.00000007014 63.0
HFD2_k127_8609466_15 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K01841 - 5.4.2.9 0.0003287 53.0
HFD2_k127_8609466_2 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 527.0
HFD2_k127_8609466_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006667 527.0
HFD2_k127_8609466_4 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 493.0
HFD2_k127_8609466_5 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008437 364.0
HFD2_k127_8609466_6 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 309.0
HFD2_k127_8609466_7 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000127 282.0
HFD2_k127_8609466_8 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000000000000000000000000000000000000000000005581 254.0
HFD2_k127_8609466_9 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000001722 208.0
HFD2_k127_8673191_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 3.145e-319 1000.0
HFD2_k127_8673191_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 529.0
HFD2_k127_8673191_2 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000009013 244.0
HFD2_k127_8673191_3 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000000000000000000000000000004457 218.0
HFD2_k127_8673191_4 Conserved protein K01163 - - 0.0000000000000000000000000001298 122.0
HFD2_k127_901285_0 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 381.0
HFD2_k127_901285_1 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 317.0
HFD2_k127_901285_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 312.0
HFD2_k127_901285_3 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 310.0
HFD2_k127_901285_4 Domain of unknown function (DUF2520) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004092 279.0
HFD2_k127_901285_5 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006496 272.0
HFD2_k127_901285_6 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.00000000000009111 71.0
HFD2_k127_909939_0 IMG reference gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 381.0
HFD2_k127_909939_1 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein - - - 0.000000000000000000000000000000000000000003279 173.0
HFD2_k127_914472_0 Belongs to the sulfate adenylyltransferase family K00958,K13811 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 610.0
HFD2_k127_914472_1 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 487.0
HFD2_k127_914472_2 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 379.0
HFD2_k127_914472_3 reductase beta subunit K00395 - 1.8.99.2 0.00000000000000000000001502 102.0
HFD2_k127_914472_4 denitrification pathway - - - 0.0000000009765 68.0
HFD2_k127_936208_0 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000986 408.0
HFD2_k127_936208_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000006173 237.0
HFD2_k127_936208_2 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000009816 218.0
HFD2_k127_936208_3 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000002383 189.0
HFD2_k127_936208_4 PFAM UspA domain protein - - - 0.000006622 55.0
HFD2_k127_936208_5 Belongs to the universal stress protein A family - - - 0.00006409 54.0
HFD2_k127_937273_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 571.0
HFD2_k127_937273_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 548.0
HFD2_k127_937273_10 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000002555 183.0
HFD2_k127_937273_11 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000002098 176.0
HFD2_k127_937273_12 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000001005 171.0
HFD2_k127_937273_13 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.0000000000000000000000000000000000000000000136 169.0
HFD2_k127_937273_14 MotA TolQ ExbB proton channel family K03561 - - 0.000000000000000000000000000000000000000003437 162.0
HFD2_k127_937273_15 PFAM Conserved carboxylase region K01571,K01960 - 4.1.1.3,6.4.1.1 0.000000000000000000000000000000000000000021 157.0
HFD2_k127_937273_16 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000009921 138.0
HFD2_k127_937273_17 - - - - 0.00000000000000000000000007054 107.0
HFD2_k127_937273_18 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000008118 97.0
HFD2_k127_937273_19 ribosomal protein L7Ae L30e S12e Gadd45 K07742 - - 0.00000000000000000004652 97.0
HFD2_k127_937273_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 533.0
HFD2_k127_937273_20 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.000000000000000002262 99.0
HFD2_k127_937273_21 Roadblock/LC7 domain - - - 0.0000000000000000037 90.0
HFD2_k127_937273_22 biopolymer transport protein K03559,K03560 - - 0.0000000000011 78.0
HFD2_k127_937273_23 - - - - 0.000008762 55.0
HFD2_k127_937273_24 translation initiation factor activity K08086 - - 0.0001562 54.0
HFD2_k127_937273_3 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 496.0
HFD2_k127_937273_4 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 432.0
HFD2_k127_937273_5 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 415.0
HFD2_k127_937273_6 COG0006 Xaa-Pro aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 323.0
HFD2_k127_937273_7 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000293 271.0
HFD2_k127_937273_8 - - - - 0.00000000000000000000000000000000000000000000000000000001288 208.0
HFD2_k127_937273_9 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000006843 190.0
HFD2_k127_94428_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 4.78e-197 623.0
HFD2_k127_94428_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 597.0
HFD2_k127_94428_10 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 409.0
HFD2_k127_94428_11 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 409.0
HFD2_k127_94428_12 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 360.0
HFD2_k127_94428_13 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 364.0
HFD2_k127_94428_14 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007857 354.0
HFD2_k127_94428_15 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 325.0
HFD2_k127_94428_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 317.0
HFD2_k127_94428_17 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008159 276.0
HFD2_k127_94428_18 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000003256 228.0
HFD2_k127_94428_19 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000004941 229.0
HFD2_k127_94428_2 FAD binding domain K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006137 579.0
HFD2_k127_94428_20 Universal stress protein family K07090 - - 0.000000000000000000000000000000000000000000000000000000001238 213.0
HFD2_k127_94428_21 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000000000000000000000000006872 207.0
HFD2_k127_94428_22 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000000000000000000000121 201.0
HFD2_k127_94428_23 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000008554 188.0
HFD2_k127_94428_24 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000001511 192.0
HFD2_k127_94428_25 - - - - 0.000000000000000000000000000000000000001442 150.0
HFD2_k127_94428_26 - - - - 0.000000000000000000000000000000000000002444 151.0
HFD2_k127_94428_27 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000001451 136.0
HFD2_k127_94428_28 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.0000000000000000000000000000002393 129.0
HFD2_k127_94428_29 HEAT repeats - - - 0.0000000000000004032 92.0
HFD2_k127_94428_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 565.0
HFD2_k127_94428_30 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.000000000000002082 83.0
HFD2_k127_94428_31 metal cluster binding - - - 0.0000000000000167 80.0
HFD2_k127_94428_32 dTDP-4-dehydrorhamnose 3,5-epimerase activity - - - 0.0000000000241 70.0
HFD2_k127_94428_33 PFAM Lytic transglycosylase catalytic - - - 0.0000001271 55.0
HFD2_k127_94428_34 Evidence 5 No homology to any previously reported sequences - - - 0.000000338 58.0
HFD2_k127_94428_38 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.00005652 54.0
HFD2_k127_94428_4 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 537.0
HFD2_k127_94428_5 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 486.0
HFD2_k127_94428_6 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 481.0
HFD2_k127_94428_7 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 466.0
HFD2_k127_94428_8 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 414.0
HFD2_k127_94428_9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 430.0
HFD2_k127_950608_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 6.63e-281 872.0
HFD2_k127_950608_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 512.0
HFD2_k127_950608_2 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000001222 237.0
HFD2_k127_950608_3 Phosphatidylserine decarboxylase K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000005069 217.0
HFD2_k127_950608_4 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000001433 205.0
HFD2_k127_971463_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 9.196e-222 698.0
HFD2_k127_971463_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.205e-194 616.0
HFD2_k127_971463_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 389.0
HFD2_k127_971463_3 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001415 270.0
HFD2_k127_971463_4 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002591 250.0
HFD2_k127_971463_5 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000007833 164.0
HFD2_k127_978904_0 leucyl-tRNA aminoacylation K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1127.0
HFD2_k127_978904_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.432e-248 778.0
HFD2_k127_978904_10 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000005457 259.0
HFD2_k127_978904_11 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000002372 232.0
HFD2_k127_978904_12 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000003358 223.0
HFD2_k127_978904_13 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000001563 218.0
HFD2_k127_978904_14 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000000000003389 213.0
HFD2_k127_978904_15 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000008335 201.0
HFD2_k127_978904_16 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000004204 137.0
HFD2_k127_978904_17 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000001699 116.0
HFD2_k127_978904_18 Histidine kinase-like ATPases - - - 0.00000000000000000000003582 115.0
HFD2_k127_978904_19 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000005611 86.0
HFD2_k127_978904_2 Pyridoxal-phosphate dependent enzyme K06001 - 4.2.1.20 7.814e-204 651.0
HFD2_k127_978904_20 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.00000000000003526 79.0
HFD2_k127_978904_21 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000003615 72.0
HFD2_k127_978904_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 609.0
HFD2_k127_978904_4 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 591.0
HFD2_k127_978904_5 Two component, sigma54 specific, transcriptional regulator, Fis family K07712,K07714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 481.0
HFD2_k127_978904_6 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 453.0
HFD2_k127_978904_7 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 391.0
HFD2_k127_978904_8 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 297.0
HFD2_k127_978904_9 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002688 278.0
HFD2_k127_986505_0 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 332.0
HFD2_k127_986505_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003789 271.0
HFD2_k127_986505_2 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004243 259.0
HFD2_k127_986505_3 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000005203 186.0
HFD2_k127_986505_4 PFAM glycosyl transferase, family 9 K02849 - - 0.00000000000000000000000000000000000000000000001092 180.0
HFD2_k127_986505_5 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000002712 146.0
HFD2_k127_986505_6 Belongs to the UPF0434 family K09791 - - 0.0000000000000000000007851 95.0