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Overview

ID MAG01658
Name HFD2_bin.5
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Bin65
Family Bin65
Genus SBBV01
Species
Assembly information
Completeness (%) 67.27
Contamination (%) 2.61
GC content (%) 67.0
N50 (bp) 5,085
Genome size (bp) 3,132,364

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3338

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1002979_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 431.0
HFD2_k127_1002979_1 AMP-binding enzyme C-terminal domain K04110,K20458 - 6.2.1.25,6.2.1.27,6.2.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 415.0
HFD2_k127_1002979_2 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 374.0
HFD2_k127_1002979_3 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 336.0
HFD2_k127_1002979_4 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 312.0
HFD2_k127_1002979_5 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000002836 205.0
HFD2_k127_1002979_6 endonuclease containing a URI domain K07461 - - 0.00000000000000000000000001004 111.0
HFD2_k127_1002979_7 Thioesterase-like superfamily K01075 - 3.1.2.23 0.00000000000000000000009577 103.0
HFD2_k127_1002979_8 - - - - 0.00004554 52.0
HFD2_k127_1004523_0 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 369.0
HFD2_k127_1004523_1 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002013 249.0
HFD2_k127_1004523_2 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000000000000001375 200.0
HFD2_k127_1004523_3 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.0000000000000000002886 91.0
HFD2_k127_1004523_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000002778 72.0
HFD2_k127_1024409_0 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 297.0
HFD2_k127_1024409_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000002836 250.0
HFD2_k127_1024409_2 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000000000000000003115 98.0
HFD2_k127_1026121_0 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000005826 260.0
HFD2_k127_1026121_1 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000009723 236.0
HFD2_k127_1026121_2 Glycine zipper 2TM domain - - - 0.00000000000000000000000006229 113.0
HFD2_k127_1049874_0 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 622.0
HFD2_k127_1049874_1 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 581.0
HFD2_k127_1049874_2 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 377.0
HFD2_k127_1049874_3 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000000000000000000000000000000001871 160.0
HFD2_k127_1050220_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.395e-208 657.0
HFD2_k127_1050220_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 450.0
HFD2_k127_1050220_2 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000001428 199.0
HFD2_k127_1050220_3 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000435 181.0
HFD2_k127_1050220_4 Thioredoxin - - - 0.0000000000006156 70.0
HFD2_k127_1050220_5 - - - - 0.0000005811 60.0
HFD2_k127_1052594_0 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 310.0
HFD2_k127_1052594_1 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007001 296.0
HFD2_k127_1052594_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.00000000000000000000000000000000008667 133.0
HFD2_k127_1052594_3 Peptidase family M23 - - - 0.00000000000002246 81.0
HFD2_k127_1063747_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 586.0
HFD2_k127_1063747_1 - - - - 0.00000000000000000000000000000000001671 154.0
HFD2_k127_1063747_2 - - - - 0.0000000000000000000000000001582 128.0
HFD2_k127_1063747_3 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000006158 86.0
HFD2_k127_1118903_0 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 336.0
HFD2_k127_1118903_1 Iron-storage protein K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000001285 213.0
HFD2_k127_1118903_2 BFD-like [2Fe-2S] binding domain K02192 - - 0.0000000000008957 71.0
HFD2_k127_1152741_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K14446 - 1.3.1.85 4.473e-223 694.0
HFD2_k127_1152741_1 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 571.0
HFD2_k127_1152741_2 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 545.0
HFD2_k127_1158739_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 346.0
HFD2_k127_1158739_1 FAD dependent oxidoreductase K00273 - 1.4.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 349.0
HFD2_k127_1158739_2 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000004333 252.0
HFD2_k127_1158739_3 Pfam:DUF2029 K13669 - - 0.000000000000000000000000000000000000000000000000000000000009461 223.0
HFD2_k127_1158739_4 PFAM Glycosyl transferase family 2 K00721,K20534 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000008705 214.0
HFD2_k127_1158739_5 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000003067 197.0
HFD2_k127_1158739_6 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000001425 160.0
HFD2_k127_1158739_7 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000003227 136.0
HFD2_k127_1158739_8 - - - - 0.00001107 57.0
HFD2_k127_1158739_9 Protein of unknown function (DUF1501) - - - 0.0002788 53.0
HFD2_k127_1164408_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 599.0
HFD2_k127_1164408_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 525.0
HFD2_k127_1164408_2 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000001356 219.0
HFD2_k127_1164408_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000002313 137.0
HFD2_k127_1164408_4 Domain of unknown function (DUF4115) K15539 - - 0.000000000000000000000000000004175 131.0
HFD2_k127_1183984_0 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 7.607e-320 1002.0
HFD2_k127_1183984_1 AcrB/AcrD/AcrF family K18138,K18307 - - 1.277e-237 750.0
HFD2_k127_1190659_0 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 319.0
HFD2_k127_1190659_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000002543 227.0
HFD2_k127_1199155_0 Bacterial extracellular solute-binding protein K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 423.0
HFD2_k127_1199155_1 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 439.0
HFD2_k127_1199155_2 Binding-protein-dependent transport system inner membrane component K05814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000446 412.0
HFD2_k127_1199155_3 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 412.0
HFD2_k127_1199155_4 Binding-protein-dependent transport system inner membrane component K05815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 391.0
HFD2_k127_1199155_5 TRAP transporter, solute receptor (TAXI family K07080 - - 0.00000000000000000000000000006553 128.0
HFD2_k127_1199155_6 NMT1-like family K07080 - - 0.00000000000000000000000005407 121.0
HFD2_k127_1199155_7 Iron-containing redox enzyme K06137 - 1.3.3.11 0.0002259 52.0
HFD2_k127_1207201_0 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 1.821e-228 717.0
HFD2_k127_1207201_1 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 289.0
HFD2_k127_1207201_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000001179 122.0
HFD2_k127_1209230_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 6.363e-222 699.0
HFD2_k127_1209230_1 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 344.0
HFD2_k127_1209230_2 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 338.0
HFD2_k127_1209230_3 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000285 286.0
HFD2_k127_1209230_4 - - - - 0.00000000000001998 80.0
HFD2_k127_1209230_5 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0001527 46.0
HFD2_k127_1209823_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 4.661e-257 803.0
HFD2_k127_1209823_1 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 435.0
HFD2_k127_1209823_2 Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 289.0
HFD2_k127_1209823_3 HD domain - - - 0.0000000000000000000000000000000693 132.0
HFD2_k127_1209823_4 Phage derived protein Gp49-like (DUF891) - - - 0.00000000000000000000000000003328 118.0
HFD2_k127_1209823_5 Helix-turn-helix domain - - - 0.000000000000000000000009693 107.0
HFD2_k127_1209823_6 4,5-dihydroxyphthalate decarboxylase - - - 0.000000000002142 68.0
HFD2_k127_1215826_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.918e-310 961.0
HFD2_k127_1215826_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.156e-217 684.0
HFD2_k127_1215826_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 342.0
HFD2_k127_1215826_3 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000002119 138.0
HFD2_k127_1215826_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000000000000141 134.0
HFD2_k127_121924_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1079.0
HFD2_k127_121924_1 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 7.757e-242 766.0
HFD2_k127_121924_2 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 541.0
HFD2_k127_121924_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 552.0
HFD2_k127_121924_4 COG1398 Fatty-acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 300.0
HFD2_k127_121924_5 Sugar (and other) transporter K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003619 288.0
HFD2_k127_121924_6 CHASE4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007502 268.0
HFD2_k127_121924_7 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000006864 53.0
HFD2_k127_1253066_0 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 602.0
HFD2_k127_1253066_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07538 - 1.1.1.368 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005162 509.0
HFD2_k127_1253066_2 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000005293 186.0
HFD2_k127_1253066_3 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000009243 112.0
HFD2_k127_1253181_0 Hydantoinase/oxoprolinase N-terminal region K01473,K10701,K10855 - 3.5.2.14,6.4.1.6,6.4.1.8 2.772e-303 955.0
HFD2_k127_1253181_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 3.281e-297 921.0
HFD2_k127_1253181_2 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 341.0
HFD2_k127_1253181_3 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 329.0
HFD2_k127_1253181_4 Isochorismatase family K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 296.0
HFD2_k127_1253181_5 ABC transporter - - - 0.00000000000000000000000000000009402 141.0
HFD2_k127_1253181_6 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000008174 102.0
HFD2_k127_1253181_7 - - - - 0.000000002477 70.0
HFD2_k127_1253181_8 sequence-specific DNA binding - - - 0.000004082 56.0
HFD2_k127_1298055_0 His Kinase A (phosphoacceptor) domain K10715 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000335 293.0
HFD2_k127_1298055_1 GH3 auxin-responsive promoter - - - 0.000000000000000000000000000000000942 136.0
HFD2_k127_1298055_2 CsbD-like - - - 0.000000000000000000002595 95.0
HFD2_k127_130155_0 Belongs to the TelA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 424.0
HFD2_k127_130155_1 PFAM 5-bromo-4-chloroindolyl phosphate hydrolysis protein - - - 0.0000000000000000000000000000000000000000000009898 177.0
HFD2_k127_130155_2 SPFH domain-Band 7 family - - - 0.00000000000000000000000005958 108.0
HFD2_k127_1303120_0 Alanine dehydrogenase/PNT, C-terminal domain K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 428.0
HFD2_k127_1303120_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 351.0
HFD2_k127_1303120_2 COG3288 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000009926 152.0
HFD2_k127_1303120_3 PRC-barrel domain - - - 0.0000000002721 69.0
HFD2_k127_1313542_0 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 456.0
HFD2_k127_1313542_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009758 271.0
HFD2_k127_1313542_2 Sugar (and other) transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002132 261.0
HFD2_k127_1313542_3 endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000335 150.0
HFD2_k127_1313542_4 FAD dependent oxidoreductase - - - 0.00000000000000006375 80.0
HFD2_k127_1313542_5 PFAM DoxX family protein K15977 - - 0.0000000000001323 76.0
HFD2_k127_1340304_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000004222 222.0
HFD2_k127_1340304_1 Cupin domain - - - 0.0000000000000000000000000000000000000000000000004057 180.0
HFD2_k127_1340304_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000001736 156.0
HFD2_k127_1340304_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000002185 92.0
HFD2_k127_134120_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 572.0
HFD2_k127_134120_1 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 361.0
HFD2_k127_134120_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000006406 138.0
HFD2_k127_1349982_0 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 4.566e-206 654.0
HFD2_k127_1349982_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 310.0
HFD2_k127_1349982_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003335 276.0
HFD2_k127_1349982_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000001187 153.0
HFD2_k127_1349982_4 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000001979 62.0
HFD2_k127_1349982_5 SnoaL-like polyketide cyclase - - - 0.0000000006062 72.0
HFD2_k127_1352110_0 peptidase, M24 K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 347.0
HFD2_k127_1352110_1 branched-chain-amino-acid transaminase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 349.0
HFD2_k127_1352110_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 354.0
HFD2_k127_1352110_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 291.0
HFD2_k127_1352110_4 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 290.0
HFD2_k127_1352110_5 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005702 278.0
HFD2_k127_1352110_6 ornithine cyclodeaminase activity K01750,K16182 - 4.3.1.12 0.00000000000000000000000000000000000000000000008913 187.0
HFD2_k127_1352110_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.00001349 55.0
HFD2_k127_135392_0 protein conserved in bacteria - - - 5.136e-201 632.0
HFD2_k127_135392_1 PFAM ABC transporter K02471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 542.0
HFD2_k127_135392_2 Glycosyl hydrolases family 15 K01178 - 3.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 372.0
HFD2_k127_135392_3 Fibronectin type III-like domain K05349 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 334.0
HFD2_k127_135392_4 ATPase with chaperone activity K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000093 239.0
HFD2_k127_1366312_0 Oxidoreductase family, C-terminal alpha/beta domain K13020 - 1.1.1.335 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 384.0
HFD2_k127_1366312_1 GHMP kinase K07031 - 2.7.1.168 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 381.0
HFD2_k127_1366312_2 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000003719 241.0
HFD2_k127_1366312_3 Polynucleotide kinase 3 phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000004491 177.0
HFD2_k127_1368993_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 337.0
HFD2_k127_1368993_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000001551 160.0
HFD2_k127_1368993_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000007956 143.0
HFD2_k127_1377820_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 8.33e-210 659.0
HFD2_k127_1377820_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.7.1.11,2.7.1.90 0.0000000001227 65.0
HFD2_k127_1380061_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 475.0
HFD2_k127_1380061_1 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 415.0
HFD2_k127_1380061_10 Hemerythrin HHE cation binding domain - - - 0.00000000000000005546 87.0
HFD2_k127_1380061_2 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 328.0
HFD2_k127_1380061_3 Belongs to the heme-copper respiratory oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 327.0
HFD2_k127_1380061_4 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 311.0
HFD2_k127_1380061_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 304.0
HFD2_k127_1380061_6 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000004233 224.0
HFD2_k127_1380061_7 ferredoxin - - - 0.000000000000000000000000000000001653 130.0
HFD2_k127_1380061_8 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000005935 98.0
HFD2_k127_1380061_9 Pfam:DUF59 - - - 0.00000000000000000158 100.0
HFD2_k127_1392282_0 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 401.0
HFD2_k127_1392282_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000127 244.0
HFD2_k127_1392282_2 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000007873 216.0
HFD2_k127_1392282_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000005372 166.0
HFD2_k127_1392282_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000004102 96.0
HFD2_k127_1412956_0 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 299.0
HFD2_k127_1412956_1 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000983 275.0
HFD2_k127_1412956_2 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - 0.000000000000000000000000000000000000000000000007512 190.0
HFD2_k127_1412956_3 PFAM binding-protein-dependent transport systems inner membrane component K02050,K15554 - - 0.0000000000000000000000000000000000000000007614 175.0
HFD2_k127_1412956_4 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K11381,K21417 - 1.2.4.4 0.000000000000000000000000000000000000000001668 164.0
HFD2_k127_1412956_5 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000009599 117.0
HFD2_k127_1415300_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 533.0
HFD2_k127_1415300_1 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000007341 190.0
HFD2_k127_1415300_2 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000000000000000000000000000004394 178.0
HFD2_k127_1415300_3 oxidation-reduction process K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000953 158.0
HFD2_k127_1415300_4 Cupin domain K11312 - - 0.00000000000000000000000000000000005323 137.0
HFD2_k127_1415300_5 - - - - 0.00003169 54.0
HFD2_k127_1422407_0 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008807 470.0
HFD2_k127_1422407_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000173 126.0
HFD2_k127_1438545_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.438e-207 654.0
HFD2_k127_1445636_0 phosphomannomutase K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 471.0
HFD2_k127_1445636_1 Beta-lactamase enzyme family K01286 - 3.4.16.4 0.0000000000000002547 89.0
HFD2_k127_1445636_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000001584 57.0
HFD2_k127_1458234_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 594.0
HFD2_k127_1458234_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 387.0
HFD2_k127_1458234_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 350.0
HFD2_k127_1458234_3 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000000000000174 235.0
HFD2_k127_1458234_4 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000002069 107.0
HFD2_k127_1458234_5 Receptor family ligand binding region K01999 - - 0.00000000000002437 79.0
HFD2_k127_145933_0 ABC transporter K02003 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 311.0
HFD2_k127_145933_1 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 297.0
HFD2_k127_145933_2 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002633 278.0
HFD2_k127_145933_3 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000001352 245.0
HFD2_k127_1463699_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 333.0
HFD2_k127_1463699_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006546 278.0
HFD2_k127_1463699_2 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000000501 216.0
HFD2_k127_1463699_3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000454 213.0
HFD2_k127_1463699_4 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000000006805 144.0
HFD2_k127_1463699_5 - - - - 0.0003029 50.0
HFD2_k127_1476487_0 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 555.0
HFD2_k127_1476487_1 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 341.0
HFD2_k127_1477953_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 3.72e-254 799.0
HFD2_k127_1477953_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000007092 243.0
HFD2_k127_1477953_2 ChrR Cupin-like domain - - - 0.00000000000000000000000000000000000000008197 155.0
HFD2_k127_1477953_3 - - - - 0.0000000001016 72.0
HFD2_k127_1479108_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 5e-321 995.0
HFD2_k127_14894_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 514.0
HFD2_k127_14894_1 Domain of unknown function (DUF4915) - - - 0.0000000000000000000000000000000000000000000000000000000093 205.0
HFD2_k127_14894_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000005642 147.0
HFD2_k127_1501955_0 COG1960 Acyl-CoA dehydrogenases K19966 - 3.13.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 569.0
HFD2_k127_1501955_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 362.0
HFD2_k127_1501955_2 COG0457 FOG TPR repeat - - - 0.0000000000007279 76.0
HFD2_k127_1502838_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 480.0
HFD2_k127_1502838_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000002706 205.0
HFD2_k127_1502838_2 Major Facilitator Superfamily - - - 0.000000000000000002035 88.0
HFD2_k127_1523713_0 Glycosyl transferase family 41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 473.0
HFD2_k127_1523713_1 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000007169 214.0
HFD2_k127_1523713_2 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0003197 48.0
HFD2_k127_152589_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 445.0
HFD2_k127_152589_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006765 434.0
HFD2_k127_152589_2 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000000000000000002744 150.0
HFD2_k127_152589_3 Uncharacterized ACR, COG1399 - - - 0.00000000000000000000004888 108.0
HFD2_k127_152589_4 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000001675 94.0
HFD2_k127_1528498_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 404.0
HFD2_k127_1528498_1 Fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 306.0
HFD2_k127_1528498_2 dehydrogenase K00253 - 1.3.8.4 0.00000000000000004215 87.0
HFD2_k127_1529779_0 - - - - 0.00000000000000000000000000000000000000000000000000000006564 200.0
HFD2_k127_1529779_1 Domain of unknown function (DUF3362) - - - 0.00000000000000000000000000000000000000000000001157 172.0
HFD2_k127_1529779_2 SnoaL-like domain - - - 0.00000000000001849 77.0
HFD2_k127_1563410_0 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008871 563.0
HFD2_k127_1563410_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 556.0
HFD2_k127_1563410_2 ABC transporter substrate-binding protein PnrA-like K02058,K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 454.0
HFD2_k127_1563410_3 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 434.0
HFD2_k127_1563410_4 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 375.0
HFD2_k127_1563410_5 COG4531 ABC-type Zn2 transport system, periplasmic component surface adhesin K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001018 263.0
HFD2_k127_1563410_6 VanW like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002052 237.0
HFD2_k127_1563410_7 - - - - 0.00000000000000000000000000000000000004565 149.0
HFD2_k127_1563410_8 - - - - 0.0006068 47.0
HFD2_k127_1570579_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 1.064e-244 772.0
HFD2_k127_1570579_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000002372 213.0
HFD2_k127_1575716_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 297.0
HFD2_k127_1575716_1 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000001223 231.0
HFD2_k127_1575716_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000002923 156.0
HFD2_k127_1575716_3 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000004073 123.0
HFD2_k127_1575716_4 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000002313 85.0
HFD2_k127_1580851_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K01782,K07516 - 1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 576.0
HFD2_k127_1580851_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000001393 103.0
HFD2_k127_1603433_0 FAD dependent oxidoreductase - - - 4.383e-196 626.0
HFD2_k127_1603433_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 331.0
HFD2_k127_1603433_2 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000001061 202.0
HFD2_k127_160662_0 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008431 510.0
HFD2_k127_160662_1 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000006439 163.0
HFD2_k127_160662_2 Peptidoglycan-binding domain 1 protein K02450,K03194,K08309 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.00000000000000000000008074 111.0
HFD2_k127_1608377_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 501.0
HFD2_k127_1608377_1 Sigma-70, region 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 379.0
HFD2_k127_1608377_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000004449 253.0
HFD2_k127_1608377_3 COG2867 Oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000000000000000000001161 197.0
HFD2_k127_1608377_4 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000001872 143.0
HFD2_k127_1608377_5 Ketosteroid isomerase-related protein - - - 0.000000000000000000000000000003537 122.0
HFD2_k127_1608377_6 CAAX protease self-immunity - - - 0.000000000000000000008387 104.0
HFD2_k127_1608646_0 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 442.0
HFD2_k127_1608646_1 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 304.0
HFD2_k127_1608646_2 NIPSNAP - - - 0.00000000000000000000000000000000000000000001938 167.0
HFD2_k127_1608646_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000002479 111.0
HFD2_k127_1615724_0 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000001574 195.0
HFD2_k127_1615724_1 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000001018 162.0
HFD2_k127_1615724_2 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000008655 131.0
HFD2_k127_1615724_3 Protein of unknown function (DUF1153) - - - 0.0000000000000004619 82.0
HFD2_k127_1645011_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008531 519.0
HFD2_k127_1645011_1 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000004681 252.0
HFD2_k127_1645011_2 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000002 229.0
HFD2_k127_1645011_3 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000000000000007098 213.0
HFD2_k127_1645011_4 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000003386 203.0
HFD2_k127_1645011_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000002418 73.0
HFD2_k127_1645011_6 Membrane K08995 - - 0.000000000002767 74.0
HFD2_k127_1645011_7 - - - - 0.00003375 50.0
HFD2_k127_1655789_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 563.0
HFD2_k127_1655789_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 329.0
HFD2_k127_1655789_2 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000006479 176.0
HFD2_k127_1655789_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000003004 158.0
HFD2_k127_1655789_4 Cold shock K03704 - - 0.00000000000000000000000003013 109.0
HFD2_k127_1655789_5 Histidine kinase - - - 0.00000000000000000000316 105.0
HFD2_k127_1687379_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007808 492.0
HFD2_k127_1687379_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 486.0
HFD2_k127_1687379_2 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000004702 254.0
HFD2_k127_1687379_3 structural constituent of ribosome K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000007104 135.0
HFD2_k127_1687379_4 Endonuclease exonuclease phosphatase - - - 0.000000000000000000000004831 117.0
HFD2_k127_1688509_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 376.0
HFD2_k127_1688509_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 337.0
HFD2_k127_1688509_2 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 305.0
HFD2_k127_1688509_3 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000001983 235.0
HFD2_k127_1688509_4 binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000009569 212.0
HFD2_k127_1688509_5 branched-chain amino acid K01995,K11957 - - 0.0000000000000000000000000000000000000000002087 162.0
HFD2_k127_1688509_6 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000559 159.0
HFD2_k127_1688509_7 ABC transporter substrate-binding protein K02051 - - 0.000004244 53.0
HFD2_k127_1721594_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000781 390.0
HFD2_k127_1721594_1 Patatin phospholipase K07001 - - 0.00000000000000000000000000000000000000002618 158.0
HFD2_k127_1729695_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 565.0
HFD2_k127_1729695_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 538.0
HFD2_k127_1729695_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 306.0
HFD2_k127_1729695_3 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001688 278.0
HFD2_k127_1729695_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000001788 182.0
HFD2_k127_1729695_5 Protein of unknown function (DUF1203) - - - 0.00000000000000000000000000000000000000000006845 180.0
HFD2_k127_1729695_6 Protein of unknown function (DUF992) - - - 0.0000000000000000000000000000000000003823 145.0
HFD2_k127_1729695_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000002296 124.0
HFD2_k127_1729695_8 transcriptional - - - 0.000000000000000000000001481 117.0
HFD2_k127_1730586_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 3.39e-229 716.0
HFD2_k127_1730586_1 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000001834 225.0
HFD2_k127_1775973_0 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005384 451.0
HFD2_k127_1775973_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 421.0
HFD2_k127_1775973_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 401.0
HFD2_k127_1775973_3 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000153 291.0
HFD2_k127_1775973_4 ABC-type dipeptide transport system periplasmic component K02035 - - 0.0000000000000000000000004866 105.0
HFD2_k127_178438_0 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 477.0
HFD2_k127_178438_1 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 350.0
HFD2_k127_178438_2 Universal stress protein UspA - - - 0.00000000000000000000000000000000000000000000001266 183.0
HFD2_k127_1786389_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 537.0
HFD2_k127_1786389_1 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 402.0
HFD2_k127_1786389_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000007921 241.0
HFD2_k127_1786389_3 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000007906 229.0
HFD2_k127_1786389_4 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000000000000000000000000000000000000001737 184.0
HFD2_k127_1790850_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 431.0
HFD2_k127_1790850_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 378.0
HFD2_k127_1790850_2 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 373.0
HFD2_k127_1790850_3 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 341.0
HFD2_k127_1790850_4 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.0000000000000000000000000000000000003059 144.0
HFD2_k127_1790850_5 FCD - - - 0.0000001914 53.0
HFD2_k127_1818102_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 481.0
HFD2_k127_1818102_1 Ribosomal RNA adenine dimethylases K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 332.0
HFD2_k127_1818102_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 298.0
HFD2_k127_1818102_3 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 297.0
HFD2_k127_1818102_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 297.0
HFD2_k127_1818102_5 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 287.0
HFD2_k127_1818102_6 YceG-like family K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 299.0
HFD2_k127_1818102_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000002013 218.0
HFD2_k127_1821041_0 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 385.0
HFD2_k127_1821041_1 Fungal trichothecene efflux pump (TRI12) - - - 0.00000000000000000000000000000000000000000000000000000000000000008366 234.0
HFD2_k127_1830427_0 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 371.0
HFD2_k127_1830427_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 352.0
HFD2_k127_1839187_0 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 338.0
HFD2_k127_1839187_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 327.0
HFD2_k127_1839187_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 290.0
HFD2_k127_1839977_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 4.535e-303 975.0
HFD2_k127_1839977_1 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009279 541.0
HFD2_k127_1839977_10 - - - - 0.000000000000000000009419 98.0
HFD2_k127_1839977_2 PFAM ABC transporter K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 411.0
HFD2_k127_1839977_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 315.0
HFD2_k127_1839977_4 dihydrokaempferol 4-reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009704 301.0
HFD2_k127_1839977_5 TIGRFAM Molybdate ABC transporter K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 294.0
HFD2_k127_1839977_6 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002499 285.0
HFD2_k127_1839977_7 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002248 230.0
HFD2_k127_1839977_8 DsrE/DsrF-like family K09004 - - 0.000000000000000000000000000000000000000001556 165.0
HFD2_k127_1839977_9 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000000000001627 130.0
HFD2_k127_1849670_0 Ammonium Transporter K03320,K06580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000967 568.0
HFD2_k127_1849670_1 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 391.0
HFD2_k127_1849670_2 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000643 286.0
HFD2_k127_1849670_3 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.000000000000000000000000000001276 140.0
HFD2_k127_185011_0 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 409.0
HFD2_k127_185011_1 'TIGRFAM RNA polymerase sigma factor, sigma-70 family' K03088 - - 0.0000000000000000005111 93.0
HFD2_k127_185011_2 'TIGRFAM RNA polymerase sigma factor, sigma-70 family' K03088 - - 0.0000000000000005932 79.0
HFD2_k127_185011_3 Protein of unknown function (DUF1800) - - - 0.00000000005086 69.0
HFD2_k127_1851345_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K04108 - 1.3.7.9 8.273e-288 915.0
HFD2_k127_1851345_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 454.0
HFD2_k127_1851345_2 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 391.0
HFD2_k127_1851345_3 ubiquitin protein ligase binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 383.0
HFD2_k127_1851345_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04109,K11178 - 1.17.1.4,1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 334.0
HFD2_k127_1851345_5 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 293.0
HFD2_k127_1851345_6 [2Fe-2S] binding domain K04107 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000001578 208.0
HFD2_k127_1851345_7 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000001029 195.0
HFD2_k127_1851345_8 EamA-like transporter family - - - 0.00000000000000000000000000000000983 139.0
HFD2_k127_1851345_9 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000001331 125.0
HFD2_k127_1854846_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001133 263.0
HFD2_k127_1854846_1 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000000000000000000000000000000000000000000008723 173.0
HFD2_k127_1854846_2 Domain of unknown function (DUF4286) - - - 0.0006963 48.0
HFD2_k127_1865547_0 This protein is involved in the repair of mismatches in DNA K03555 - - 0.0 1121.0
HFD2_k127_1865547_1 malic enzyme K00029 - 1.1.1.40 0.0 1069.0
HFD2_k127_1865547_2 Bacterial PH domain - - - 0.00000000000000000000000000000000002325 140.0
HFD2_k127_1865547_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00797 - 2.5.1.16 0.000000000000000000000000000001541 125.0
HFD2_k127_1880956_0 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 336.0
HFD2_k127_1880956_1 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000158 228.0
HFD2_k127_1880956_2 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000385 229.0
HFD2_k127_1880956_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000000000000000000001148 195.0
HFD2_k127_1880956_4 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000000000001351 180.0
HFD2_k127_1888823_0 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 1.829e-199 630.0
HFD2_k127_1888823_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 578.0
HFD2_k127_1888823_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 331.0
HFD2_k127_1888823_3 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000001585 198.0
HFD2_k127_1898460_0 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K01784,K03274 - 5.1.3.2,5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 408.0
HFD2_k127_1898460_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004023 282.0
HFD2_k127_1898460_2 Putative bacterial sensory transduction regulator - - - 0.00000000000000000000000000000000000000000000000000000000000009909 220.0
HFD2_k127_1898460_3 protein conserved in bacteria K09806 - - 0.00000000000001733 78.0
HFD2_k127_1898460_4 Belongs to the DapB family K00215 - 1.17.1.8 0.0001761 52.0
HFD2_k127_189970_0 Transport of potassium into the cell K03549 - - 3.818e-220 699.0
HFD2_k127_189970_1 glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 272.0
HFD2_k127_189970_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001855 260.0
HFD2_k127_189970_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000005187 238.0
HFD2_k127_1902561_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.01e-225 713.0
HFD2_k127_1902561_1 COG0534 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 425.0
HFD2_k127_1902561_10 Lipid A Biosynthesis - - - 0.000000000000009196 87.0
HFD2_k127_1902561_11 - - - - 0.00000000000008432 80.0
HFD2_k127_1902561_12 - - - - 0.00000000001201 74.0
HFD2_k127_1902561_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 346.0
HFD2_k127_1902561_3 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000923 250.0
HFD2_k127_1902561_4 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000003887 240.0
HFD2_k127_1902561_5 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000007797 216.0
HFD2_k127_1902561_6 Intracellular septation protein A K06190 - - 0.0000000000000000000000000000000000000000000000000005154 190.0
HFD2_k127_1902561_7 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000001139 150.0
HFD2_k127_1902561_8 Bacterial transcriptional repressor C-terminal K16137 - - 0.0000000000000000000000000000000000003657 147.0
HFD2_k127_1902561_9 protein possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000001346 148.0
HFD2_k127_1903103_0 transport system fused permease components - - - 3.853e-293 916.0
HFD2_k127_1903103_1 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 471.0
HFD2_k127_1903103_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000002051 234.0
HFD2_k127_1903103_3 chorismate mutase - - - 0.00000000000003244 76.0
HFD2_k127_1914415_0 ATP-dependent helicase K03579 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000003431 205.0
HFD2_k127_1914415_1 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000001408 152.0
HFD2_k127_1914415_2 Protein of unknown function (DUF459) K09795 - - 0.0000000000000000000000000000003221 133.0
HFD2_k127_1914415_3 Protein of unknown function (DUF459) K09795 - - 0.000000000000000000000000000001769 130.0
HFD2_k127_191663_0 GDP-mannose 4,6 dehydratase K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 497.0
HFD2_k127_191663_1 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 329.0
HFD2_k127_191663_2 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001471 278.0
HFD2_k127_191663_3 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000007094 192.0
HFD2_k127_191663_4 YdjC-like protein K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000000009163 185.0
HFD2_k127_191663_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000002638 173.0
HFD2_k127_191663_6 ABC-2 type transporter K01992,K09690 - - 0.000000000000000000000000000000000000000002675 166.0
HFD2_k127_191663_7 KR domain - - - 0.0000000000000000000000000000003324 127.0
HFD2_k127_1918066_0 OpgC protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 415.0
HFD2_k127_1918066_1 arsR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 353.0
HFD2_k127_1918066_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000007425 203.0
HFD2_k127_1918066_3 PFAM lipolytic protein G-D-S-L family - - - 0.000000007162 63.0
HFD2_k127_1926471_0 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000002135 220.0
HFD2_k127_1926471_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000001137 216.0
HFD2_k127_1926471_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000009769 171.0
HFD2_k127_1926471_3 of membrane protease K07340 - - 0.0000000000000000000000000000000004594 136.0
HFD2_k127_1926471_4 Protein of unknown function, DUF488 - - - 0.000000000000009124 75.0
HFD2_k127_1926471_5 - - - - 0.00002779 55.0
HFD2_k127_1933054_0 Methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 3.611e-219 707.0
HFD2_k127_1933054_1 Homocysteine S-methyltransferase K00544,K00548 - 2.1.1.13,2.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 434.0
HFD2_k127_1933054_2 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000002035 250.0
HFD2_k127_1940639_0 TIGRFAM methylmalonyl-CoA mutase N-terminal domain K01848 - 5.4.99.2 0.00000000000000000000000000000000000001414 149.0
HFD2_k127_1940639_1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000000004556 127.0
HFD2_k127_1940639_2 GTP-binding protein TypA K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.000000000000000000000006676 104.0
HFD2_k127_1940639_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000002914 93.0
HFD2_k127_1950929_0 AMP-binding enzyme K01897 - 6.2.1.3 9.647e-205 655.0
HFD2_k127_1950929_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 359.0
HFD2_k127_1950929_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 316.0
HFD2_k127_1950929_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 334.0
HFD2_k127_1950929_4 AAA domain, putative AbiEii toxin, Type IV TA system K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 292.0
HFD2_k127_1950929_5 ADP-glyceromanno-heptose 6-epimerase activity K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001912 274.0
HFD2_k127_1950929_6 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000003374 191.0
HFD2_k127_1950929_7 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000494 176.0
HFD2_k127_1972543_0 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 371.0
HFD2_k127_1972543_1 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000003026 113.0
HFD2_k127_1984782_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 554.0
HFD2_k127_1984782_1 COG0480 Translation elongation factors (GTPases) K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 462.0
HFD2_k127_1984782_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000313 196.0
HFD2_k127_1984782_3 ribonuclease - - - 0.00000000000000000000000000002506 125.0
HFD2_k127_1984782_4 Barstar (barnase inhibitor) K03623 - - 0.00000001476 65.0
HFD2_k127_1985270_0 Tripartite tricarboxylate transporter TctA family - - - 1.793e-203 644.0
HFD2_k127_1985270_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000736 275.0
HFD2_k127_1985270_2 PFAM conserved - - - 0.0000000000000000000008144 98.0
HFD2_k127_1985270_3 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000008698 104.0
HFD2_k127_1989864_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 491.0
HFD2_k127_1989864_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 381.0
HFD2_k127_1989864_2 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000000000000001021 87.0
HFD2_k127_1990358_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008645 579.0
HFD2_k127_1990358_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162,K00627 - 1.2.4.1,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 449.0
HFD2_k127_1990358_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 312.0
HFD2_k127_1993256_0 Magnesium transport protein CorA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 587.0
HFD2_k127_1993256_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001131 271.0
HFD2_k127_1993256_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000007778 218.0
HFD2_k127_1999735_0 Proton-conducting membrane transporter - - - 2.46e-286 894.0
HFD2_k127_1999735_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 390.0
HFD2_k127_1999735_2 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000001571 249.0
HFD2_k127_1999735_3 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000001392 119.0
HFD2_k127_2002828_0 Belongs to the 5'-nucleotidase family K17224 - - 8.716e-268 833.0
HFD2_k127_2002828_1 Cytochrome c biogenesis protein K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001196 271.0
HFD2_k127_2002828_2 Cytochrome c K17230 - - 0.0000000000000000000000000000000000000006469 149.0
HFD2_k127_2002828_3 transcription activator K03707 - 3.5.99.2 0.0000000000005426 70.0
HFD2_k127_2009184_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.968e-234 730.0
HFD2_k127_2009184_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.887e-202 640.0
HFD2_k127_2009184_10 Metal-sensitive transcriptional repressor K21600 - - 0.00000000004777 63.0
HFD2_k127_2009184_11 acetyltransferase K03823 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 2.3.1.183 0.00001716 56.0
HFD2_k127_2009184_2 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 563.0
HFD2_k127_2009184_3 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 477.0
HFD2_k127_2009184_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 320.0
HFD2_k127_2009184_5 Phytanoyl-CoA dioxygenase (PhyH) K21195 - 1.14.11.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 306.0
HFD2_k127_2009184_6 MobA-like NTP transferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 291.0
HFD2_k127_2009184_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000005124 222.0
HFD2_k127_2009184_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000007559 200.0
HFD2_k127_2009184_9 PAS domain - - - 0.0000000000000000000000000000000538 131.0
HFD2_k127_2015962_0 COG1960 Acyl-CoA dehydrogenases K20035 - - 5.67e-210 664.0
HFD2_k127_2015962_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 394.0
HFD2_k127_2015962_2 TIGRFAM cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 362.0
HFD2_k127_2051453_0 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 5.437e-229 721.0
HFD2_k127_2051453_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 602.0
HFD2_k127_2051453_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 398.0
HFD2_k127_2051453_3 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000001818 227.0
HFD2_k127_2051453_4 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000208 211.0
HFD2_k127_2051453_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000001068 118.0
HFD2_k127_2054307_0 Fibronectin type III-like domain K05349 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 464.0
HFD2_k127_2054307_1 Methionine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 446.0
HFD2_k127_2054307_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00446 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 317.0
HFD2_k127_2054307_3 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005196 319.0
HFD2_k127_2054307_4 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000001568 56.0
HFD2_k127_2054307_5 Methionine synthase - - - 0.000005069 48.0
HFD2_k127_207057_0 COG3839 ABC-type sugar transport systems, ATPase components K05816 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 451.0
HFD2_k127_207057_1 Bacterial extracellular solute-binding protein K05813 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004196 271.0
HFD2_k127_2072306_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 516.0
HFD2_k127_2072306_1 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 414.0
HFD2_k127_2072306_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007884 407.0
HFD2_k127_2072306_3 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008624 301.0
HFD2_k127_2072306_4 Belongs to the binding-protein-dependent transport system permease family K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006154 280.0
HFD2_k127_2072306_5 ROS/MUCR transcriptional regulator protein - - - 0.0000000000000000000000000000000000000000000000000002056 191.0
HFD2_k127_2072306_6 COG0698 Ribose 5-phosphate isomerase RpiB K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000414 176.0
HFD2_k127_2072306_7 - - - - 0.000000000000000000000004757 115.0
HFD2_k127_2084718_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 298.0
HFD2_k127_2084718_1 Sulphur oxidation protein SoxZ - - - 0.000000000000000000000003706 105.0
HFD2_k127_2084718_2 - - - - 0.00000000000000000000007424 100.0
HFD2_k127_2084718_3 sulfur oxidation protein (SoxY) K17226 - - 0.000000000000000001408 87.0
HFD2_k127_2084718_4 - - - - 0.00000000001219 72.0
HFD2_k127_2090561_0 COG0513 Superfamily II DNA and RNA helicases K17675 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 566.0
HFD2_k127_2090561_1 Protein of unknown function (DUF1223) - - - 0.0000000000000000000000000000000000000000000000001432 185.0
HFD2_k127_2090561_2 Major Facilitator Superfamily - - - 0.00000000000001666 78.0
HFD2_k127_2117550_0 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003692 251.0
HFD2_k127_2117550_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000007959 230.0
HFD2_k127_2117550_2 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.0000000000000000000000001653 106.0
HFD2_k127_212529_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 4e-323 998.0
HFD2_k127_212529_1 of ABC transporters with duplicated ATPase K06158 - - 7.921e-211 663.0
HFD2_k127_212529_2 drug transmembrane transport K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 433.0
HFD2_k127_212529_3 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 363.0
HFD2_k127_212529_4 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 351.0
HFD2_k127_212529_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000001512 203.0
HFD2_k127_212529_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000001724 106.0
HFD2_k127_2133015_0 KR domain K21883 - 1.1.1.401 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 291.0
HFD2_k127_2133015_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000004043 166.0
HFD2_k127_2133015_2 arsenate reductase K00537 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 0.0000000000000000000000000000000003239 134.0
HFD2_k127_2133015_3 MarR family - - - 0.0000000000000000000001736 104.0
HFD2_k127_2133015_4 Universal stress protein - - - 0.000000000003251 68.0
HFD2_k127_2147522_0 Thiamine pyrophosphate enzyme, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 372.0
HFD2_k127_2147522_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K08690,K14582 - 1.3.1.29,1.3.1.56,1.3.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000002996 252.0
HFD2_k127_2147522_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000534 223.0
HFD2_k127_2147522_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000006442 150.0
HFD2_k127_2147522_4 Rieske [2Fe-2S] domain - - - 0.00000000000003965 76.0
HFD2_k127_2148320_0 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 348.0
HFD2_k127_2148320_1 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000003216 229.0
HFD2_k127_2148320_2 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000003137 206.0
HFD2_k127_2148320_3 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000003672 196.0
HFD2_k127_2148320_4 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000008812 209.0
HFD2_k127_2148320_5 Nitrate ABC transporter permease K02050 - - 0.0000000000000000000000000000000000000000000000001803 191.0
HFD2_k127_2148320_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000001373 139.0
HFD2_k127_2148320_7 - - - - 0.00000000000000000000000000001183 125.0
HFD2_k127_2153271_0 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 379.0
HFD2_k127_2153271_1 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 348.0
HFD2_k127_2153271_2 Extracellular liganD-binding receptor K01999 - - 0.00000000000000000000000001468 109.0
HFD2_k127_2193572_0 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000003372 194.0
HFD2_k127_2193572_1 Alpha beta hydrolase - - - 0.00000000000000000002825 103.0
HFD2_k127_2193572_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000001277 84.0
HFD2_k127_2193572_3 Glycosyl transferase family 21 - - - 0.0000000000003118 78.0
HFD2_k127_2196112_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 4.486e-226 708.0
HFD2_k127_2196112_1 Aldehyde oxidase and xanthine dehydrogenase K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 381.0
HFD2_k127_2196112_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000284 285.0
HFD2_k127_2196112_3 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001006 254.0
HFD2_k127_2207831_0 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 369.0
HFD2_k127_2207831_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000001741 257.0
HFD2_k127_2207831_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000007058 114.0
HFD2_k127_2226899_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 1.048e-263 837.0
HFD2_k127_2232733_0 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 494.0
HFD2_k127_2232733_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 333.0
HFD2_k127_2232733_2 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009698 346.0
HFD2_k127_2232733_3 Carboxylesterase family K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005861 271.0
HFD2_k127_2232733_4 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000003883 214.0
HFD2_k127_2232733_5 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000000000000000000000008099 187.0
HFD2_k127_2232733_6 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000003336 70.0
HFD2_k127_2232733_7 Protein kinase domain - - - 0.00000004765 57.0
HFD2_k127_2246361_0 signal transduction histidine kinase K13587 - 2.7.13.3 2.247e-197 645.0
HFD2_k127_2246361_1 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 368.0
HFD2_k127_2246361_2 Encapsulating protein for peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005714 327.0
HFD2_k127_2246361_3 Putative zinc-finger - - - 0.000000000000000000000000000000000000000000000000526 192.0
HFD2_k127_2246361_4 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000000008872 175.0
HFD2_k127_2246361_5 Evidence 4 Homologs of previously reported genes of K09700 - - 0.0000000000000000000000000000000000000002165 154.0
HFD2_k127_2246361_6 Trypsin - - - 0.0000000000000000001207 103.0
HFD2_k127_2246361_7 HxlR-like helix-turn-helix - - - 0.000392 44.0
HFD2_k127_2249798_0 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 577.0
HFD2_k127_2249798_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 479.0
HFD2_k127_2249798_2 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 350.0
HFD2_k127_2249798_3 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 336.0
HFD2_k127_2249798_4 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000008365 121.0
HFD2_k127_2249798_5 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position - - - 0.00000000353 58.0
HFD2_k127_2250983_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 425.0
HFD2_k127_2250983_1 transcriptional - - - 0.000000000000000000000000000000000000000000004464 168.0
HFD2_k127_2250983_2 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000001754 116.0
HFD2_k127_2253597_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 441.0
HFD2_k127_2253597_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 386.0
HFD2_k127_2253597_2 PFAM Pentapeptide repeats (8 copies) - - - 0.0000000000008216 73.0
HFD2_k127_2254418_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 337.0
HFD2_k127_2261465_0 Transglycosylase SLT domain K00786,K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 528.0
HFD2_k127_2261465_1 monooxygenase - - - 0.000000000000000000000007913 110.0
HFD2_k127_226610_0 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002736 243.0
HFD2_k127_226610_1 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000007316 229.0
HFD2_k127_226610_2 Methionine aminopeptidase K01265 - 3.4.11.18 0.000000000000000000000000000000000000005848 148.0
HFD2_k127_226610_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000001408 74.0
HFD2_k127_2283054_0 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 1.217e-196 632.0
HFD2_k127_2283054_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 332.0
HFD2_k127_2317917_0 Belongs to the thiolase family K00626 - 2.3.1.9 7.725e-198 624.0
HFD2_k127_2317917_1 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001974 235.0
HFD2_k127_2317917_2 alpha/beta hydrolase fold K03821 - - 0.0000000000000000000000000000000000000000000000000002566 188.0
HFD2_k127_2317917_3 - - - - 0.0000000000000000000000000006068 120.0
HFD2_k127_239957_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 467.0
HFD2_k127_239957_1 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000005169 263.0
HFD2_k127_239957_2 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000007063 144.0
HFD2_k127_2415966_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 4.316e-288 900.0
HFD2_k127_2415966_1 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 512.0
HFD2_k127_2415966_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000009164 147.0
HFD2_k127_2415966_3 Peptidase M16 K07263,K07623 - - 0.000000000000000000000000007063 115.0
HFD2_k127_241779_0 4Fe-4S dicluster domain K17723 - 1.3.1.1 8.646e-225 715.0
HFD2_k127_241779_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K17722 - 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 582.0
HFD2_k127_241779_2 Carbon-nitrogen hydrolase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 481.0
HFD2_k127_241779_3 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000001527 168.0
HFD2_k127_241779_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799,K18990 - - 0.00000000000000000000000000000000000005311 162.0
HFD2_k127_2418884_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006979 517.0
HFD2_k127_2418884_1 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 351.0
HFD2_k127_2418884_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008795 307.0
HFD2_k127_2418884_3 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000006627 206.0
HFD2_k127_2431928_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.41e-256 795.0
HFD2_k127_2431928_1 PAS PAC domain-containing protein - - - 4.807e-194 634.0
HFD2_k127_2431928_2 Aspartate tyrosine aromatic aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 471.0
HFD2_k127_2440992_0 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 588.0
HFD2_k127_2440992_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 340.0
HFD2_k127_2440992_2 Cytochrome c K17230 - - 0.0000000000000000000000000000000000000000000000000000000000000002837 231.0
HFD2_k127_2452527_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.433e-318 994.0
HFD2_k127_2452527_1 Protein tyrosine phosphatase - - - 0.000000000000000000000000000000001093 137.0
HFD2_k127_2452527_2 Transcriptional regulator K13634,K13635 GO:0006792,GO:0008150,GO:0045883,GO:0048518,GO:0050789,GO:0065007 - 0.000001858 54.0
HFD2_k127_2469720_0 carbamoyl transferase, NodU family K00612 - - 1.477e-237 742.0
HFD2_k127_2469720_1 - - - - 0.00000000000159 67.0
HFD2_k127_2481729_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003484 263.0
HFD2_k127_2481729_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00612 - - 0.00000000000000000000000000000000000000002679 154.0
HFD2_k127_2481729_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000008726 119.0
HFD2_k127_2485072_0 Hydantoinase oxoprolinase N-terminal region K01469 - 3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 541.0
HFD2_k127_2485072_1 Protein of unknown function (DUF979) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 370.0
HFD2_k127_2485072_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008099 269.0
HFD2_k127_2485072_3 PFAM Bacterial protein of - - - 0.000000000000000000000000000000000000000000000000000000005936 214.0
HFD2_k127_2485072_4 Protein of unknown function (DUF2891) - - - 0.00003024 47.0
HFD2_k127_249732_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007242 279.0
HFD2_k127_249732_1 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005011 243.0
HFD2_k127_249732_2 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000002608 144.0
HFD2_k127_249732_3 Domain of unknown function (DUF1989) K09967 - - 0.00000000000000000000000693 109.0
HFD2_k127_251542_0 transport system fused permease components - - - 3.561e-262 825.0
HFD2_k127_251542_1 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000003101 183.0
HFD2_k127_251542_2 Rhamnan synthesis protein F - - - 0.000000000000000000000000001025 124.0
HFD2_k127_2567607_0 Amidase - - - 2.464e-247 781.0
HFD2_k127_2567607_1 ATPases associated with a variety of cellular activities K01995,K11962 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 299.0
HFD2_k127_2567607_2 ATPases associated with a variety of cellular activities K01996,K11963 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002648 251.0
HFD2_k127_2567607_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000001558 56.0
HFD2_k127_2574299_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 4.712e-274 854.0
HFD2_k127_2634450_0 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 466.0
HFD2_k127_2634450_1 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 372.0
HFD2_k127_2634450_2 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K10619 - 1.14.12.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 355.0
HFD2_k127_2634450_3 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 334.0
HFD2_k127_2634450_4 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051,K15553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 314.0
HFD2_k127_2634450_5 FCD - - - 0.00000000000000000000000000000000000000000000000001403 190.0
HFD2_k127_2634450_6 Cupin domain - - - 0.0000000000000000000005858 102.0
HFD2_k127_2634450_7 UTRA K03710 - - 0.000000000000000004013 94.0
HFD2_k127_2634450_8 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit - - - 0.00002177 48.0
HFD2_k127_2636555_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 569.0
HFD2_k127_2636555_1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 537.0
HFD2_k127_2636555_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 337.0
HFD2_k127_2636555_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 316.0
HFD2_k127_2636555_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 314.0
HFD2_k127_2636555_5 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002298 257.0
HFD2_k127_2636555_6 Uncharacterised protein family (UPF0262) - - - 0.000000000000000000000000000000000000000000000000000000000001959 214.0
HFD2_k127_2636555_7 protein possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000000000000000008951 180.0
HFD2_k127_2636555_8 Low molecular weight phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.0000000000000000000000000000000001203 142.0
HFD2_k127_2636555_9 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000003765 116.0
HFD2_k127_2637086_0 Methylmalonyl-CoA mutase K01847,K01848,K14447,K20906 - 5.4.99.2,5.4.99.63,5.4.99.64 3.291e-242 761.0
HFD2_k127_2637086_1 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005893 260.0
HFD2_k127_2637086_2 COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) K01849,K20907 - 5.4.99.2,5.4.99.64 0.000000000000000000000000000000000000000000000000002649 184.0
HFD2_k127_2637086_3 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000008544 167.0
HFD2_k127_2637086_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000001416 155.0
HFD2_k127_2653873_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 8.874e-301 928.0
HFD2_k127_2653873_1 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 554.0
HFD2_k127_2653873_2 COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding) K01849,K20907 - 5.4.99.2,5.4.99.64 0.000000000000008832 74.0
HFD2_k127_2654099_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001075 252.0
HFD2_k127_2654099_1 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000006548 140.0
HFD2_k127_2658917_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.75e-275 859.0
HFD2_k127_2658917_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001306 262.0
HFD2_k127_2658917_2 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000008821 96.0
HFD2_k127_2663767_0 transport system fused permease components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 572.0
HFD2_k127_2663767_1 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 515.0
HFD2_k127_2663767_2 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 332.0
HFD2_k127_2663767_3 TRAP transporter solute receptor TAXI family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 317.0
HFD2_k127_2663767_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000001336 156.0
HFD2_k127_2663767_5 Uncharacterized protein family UPF0016 - - - 0.00000000000000000000000000003246 119.0
HFD2_k127_2663767_6 Cation transport regulator K06197 - - 0.00000000000000001522 86.0
HFD2_k127_266510_0 acetyl-coa acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009192 576.0
HFD2_k127_266510_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 466.0
HFD2_k127_266510_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 345.0
HFD2_k127_2680293_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 474.0
HFD2_k127_2684666_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 584.0
HFD2_k127_2684666_1 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 338.0
HFD2_k127_2689040_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01847 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 563.0
HFD2_k127_2689040_1 PFAM Cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000345 170.0
HFD2_k127_2689040_2 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000000000000000001969 133.0
HFD2_k127_2695077_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 2.17e-209 663.0
HFD2_k127_2695077_1 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 281.0
HFD2_k127_2695077_2 PIN domain K07062 - - 0.000000000000000000000000000000000000000000003414 170.0
HFD2_k127_2695077_3 - - - - 0.0000000000000000003713 93.0
HFD2_k127_2695711_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 323.0
HFD2_k127_2695711_1 Flavodoxin-like fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000141 267.0
HFD2_k127_2695711_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000005026 147.0
HFD2_k127_2695711_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000001841 83.0
HFD2_k127_2696777_0 AMP-binding enzyme C-terminal domain K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 593.0
HFD2_k127_2696777_1 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000223 166.0
HFD2_k127_2700431_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 3.838e-236 748.0
HFD2_k127_2700431_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 389.0
HFD2_k127_2700431_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000231 224.0
HFD2_k127_2713552_0 Protein conserved in bacteria K07793 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 440.0
HFD2_k127_2713552_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000879 212.0
HFD2_k127_2713552_2 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000000002372 174.0
HFD2_k127_2727995_0 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000822 501.0
HFD2_k127_2727995_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000673 280.0
HFD2_k127_272853_0 PEP-utilising enzyme, TIM barrel domain K01007 - 2.7.9.2 9.568e-245 767.0
HFD2_k127_272853_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 3.721e-242 758.0
HFD2_k127_2745284_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.221e-281 878.0
HFD2_k127_2745284_1 EamA-like transporter family - - - 0.00000000000000000000002294 110.0
HFD2_k127_2749693_0 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000002829 125.0
HFD2_k127_2749693_1 Phenylacetic acid catabolic protein - - - 0.00000000000000000000000000001607 131.0
HFD2_k127_2756725_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 312.0
HFD2_k127_2756725_1 Protein of unknown function (DUF448) K07742 - - 0.0000000000000000000000000000000000000003297 158.0
HFD2_k127_2763047_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 404.0
HFD2_k127_2763047_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000003935 247.0
HFD2_k127_2763047_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000003388 51.0
HFD2_k127_2782944_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.213e-228 713.0
HFD2_k127_2782944_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000006046 271.0
HFD2_k127_2782944_2 FR47-like protein - - - 0.00000000000000000000000000000000000000000002406 177.0
HFD2_k127_2782944_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000007989 133.0
HFD2_k127_2793499_0 Prolyl oligopeptidase K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 282.0
HFD2_k127_2793499_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000009074 234.0
HFD2_k127_2795137_0 Amidohydrolase K10220 - 4.2.1.83 0.0000000000000000000000000000000000000000000000000000000000000004495 227.0
HFD2_k127_2795137_1 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000000000000000001961 184.0
HFD2_k127_2795137_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000008382 148.0
HFD2_k127_2802319_0 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 610.0
HFD2_k127_2802319_1 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 452.0
HFD2_k127_2802319_2 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001267 271.0
HFD2_k127_2802319_3 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007868 245.0
HFD2_k127_2802319_4 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.0000000000000000000000000000000000000000000000006059 180.0
HFD2_k127_2802319_5 ThiS family - - - 0.0000000000000000000000000189 111.0
HFD2_k127_2825500_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 284.0
HFD2_k127_2825500_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000001481 253.0
HFD2_k127_2825500_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000001757 230.0
HFD2_k127_2831855_0 ribosomal rna small subunit methyltransferase - - - 2.547e-205 650.0
HFD2_k127_2831855_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 328.0
HFD2_k127_2831855_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000001648 264.0
HFD2_k127_2834663_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 546.0
HFD2_k127_2834663_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 314.0
HFD2_k127_2834663_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 295.0
HFD2_k127_2834663_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000008144 92.0
HFD2_k127_2837578_0 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 341.0
HFD2_k127_2837578_1 esterase K01432 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 304.0
HFD2_k127_2837578_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000004159 200.0
HFD2_k127_2841070_0 Cupin superfamily protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 565.0
HFD2_k127_2842875_0 Sulfite reductase K00381 - 1.8.1.2 9.981e-256 798.0
HFD2_k127_2842875_1 AMP-binding enzyme C-terminal domain - - - 1.874e-244 766.0
HFD2_k127_2842875_10 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000002019 261.0
HFD2_k127_2842875_11 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000004693 236.0
HFD2_k127_2842875_12 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000006386 225.0
HFD2_k127_2842875_13 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000001542 195.0
HFD2_k127_2842875_14 Bacterial protein of unknown function (DUF934) - - - 0.00000000000000000000000000000000007011 140.0
HFD2_k127_2842875_15 Protein of unknown function (DUF2849) - - - 0.000000002131 67.0
HFD2_k127_2842875_2 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 1.179e-195 636.0
HFD2_k127_2842875_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 586.0
HFD2_k127_2842875_4 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 494.0
HFD2_k127_2842875_5 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 467.0
HFD2_k127_2842875_6 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 426.0
HFD2_k127_2842875_7 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 405.0
HFD2_k127_2842875_8 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 364.0
HFD2_k127_2842875_9 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 332.0
HFD2_k127_2846504_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01907 - 6.2.1.1,6.2.1.16 3.518e-283 880.0
HFD2_k127_2846504_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 615.0
HFD2_k127_2846504_2 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 601.0
HFD2_k127_2846504_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 527.0
HFD2_k127_2846504_4 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 330.0
HFD2_k127_2846504_5 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 293.0
HFD2_k127_2846504_6 Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) K05774 - 2.7.4.23 0.00000000000000000000000000000000000000001601 158.0
HFD2_k127_2847511_0 Zn-dependent protease, contains TPR repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 373.0
HFD2_k127_2847511_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001366 252.0
HFD2_k127_2847511_2 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000000000003966 218.0
HFD2_k127_2851627_0 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 500.0
HFD2_k127_2851627_1 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 409.0
HFD2_k127_2851627_10 - - - - 0.00000000002688 73.0
HFD2_k127_2851627_11 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000003799 61.0
HFD2_k127_2851627_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 377.0
HFD2_k127_2851627_3 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000001568 244.0
HFD2_k127_2851627_4 Major Facilitator Superfamily K18567 - - 0.0000000000000000000000000000000000000000000000000000000000000005978 235.0
HFD2_k127_2851627_5 Bacterial regulatory proteins, tetR family K16137 - - 0.000000000000000000000000000000000000000000000000000000002691 205.0
HFD2_k127_2851627_6 - - - - 0.0000000000000000000000000000000000000000000005166 177.0
HFD2_k127_2851627_7 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000008771 175.0
HFD2_k127_2851627_8 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000002037 138.0
HFD2_k127_2851627_9 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000005581 130.0
HFD2_k127_285239_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 548.0
HFD2_k127_285239_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 346.0
HFD2_k127_285239_2 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000003378 143.0
HFD2_k127_285239_3 nuclease activity - - - 0.00000000000000000000000000003504 124.0
HFD2_k127_285239_4 (GMC) oxidoreductase K00108 - 1.1.99.1 0.0000006805 52.0
HFD2_k127_2857247_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 561.0
HFD2_k127_2857247_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 301.0
HFD2_k127_2857247_2 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007389 248.0
HFD2_k127_2857247_3 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000000000000003147 209.0
HFD2_k127_2857247_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993 - - 0.0000000000000000000000000000000000000000000001568 179.0
HFD2_k127_2866762_0 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 299.0
HFD2_k127_2866762_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002597 254.0
HFD2_k127_2866762_2 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007211 243.0
HFD2_k127_2866762_3 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000004161 174.0
HFD2_k127_2866762_4 Ferredoxin - - - 0.000000000000000000000000000144 124.0
HFD2_k127_2877030_0 Belongs to the ABC transporter superfamily K13896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 524.0
HFD2_k127_2877030_1 transport system, permease component K13895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 497.0
HFD2_k127_2877030_2 transport system, permease component K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 466.0
HFD2_k127_2877030_3 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 0.00000000000000006875 82.0
HFD2_k127_2885318_0 Alpha-2-Macroglobulin K06894 - - 1.122e-309 997.0
HFD2_k127_2885318_1 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000000000000000000000000007537 209.0
HFD2_k127_2885318_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000001424 208.0
HFD2_k127_2885318_3 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000001491 168.0
HFD2_k127_2885318_4 Protein of unknown function (DUF2927) - - - 0.00000000000000000007516 100.0
HFD2_k127_2905598_0 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 518.0
HFD2_k127_2905598_1 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000238 256.0
HFD2_k127_2905598_2 COG3000 Sterol desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005946 240.0
HFD2_k127_2905598_3 NMT1-like family K07080 - - 0.00000000001106 66.0
HFD2_k127_2912589_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 487.0
HFD2_k127_2912589_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000002019 190.0
HFD2_k127_2912589_2 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000000001293 182.0
HFD2_k127_2928046_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 428.0
HFD2_k127_2928046_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008923 353.0
HFD2_k127_2928046_2 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000007915 187.0
HFD2_k127_2928046_3 PFAM Uncharacterised protein family UPF0027 K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000001353 183.0
HFD2_k127_2928046_4 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000000000000001944 151.0
HFD2_k127_2928046_5 - - - - 0.00006956 54.0
HFD2_k127_294558_0 AMP-binding enzyme C-terminal domain - - - 3.121e-207 657.0
HFD2_k127_294558_1 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 467.0
HFD2_k127_294558_2 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 325.0
HFD2_k127_294558_3 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000007105 243.0
HFD2_k127_294558_4 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000001197 216.0
HFD2_k127_294558_5 Alkylated DNA repair protein K03919 - 1.14.11.33 0.0000000000000000000000000000000000000000000000000000000262 198.0
HFD2_k127_294558_6 PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000008068 202.0
HFD2_k127_294558_7 PAS fold - - - 0.000000000008101 77.0
HFD2_k127_294558_8 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000566 54.0
HFD2_k127_295930_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000004865 216.0
HFD2_k127_295930_1 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000002692 120.0
HFD2_k127_2961177_0 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 357.0
HFD2_k127_2961177_1 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 306.0
HFD2_k127_2961177_2 Cysteine dioxygenase type I - - - 0.00000000000000000000000000000000000004065 150.0
HFD2_k127_2962214_0 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 372.0
HFD2_k127_2962214_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000003831 234.0
HFD2_k127_2963975_0 GatB domain K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 464.0
HFD2_k127_2963975_1 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008111 346.0
HFD2_k127_2963975_2 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002013 282.0
HFD2_k127_2963975_3 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005905 263.0
HFD2_k127_2965984_0 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008507 265.0
HFD2_k127_2965984_1 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000001754 227.0
HFD2_k127_2965984_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000003502 156.0
HFD2_k127_2965984_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000002341 149.0
HFD2_k127_2965984_4 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.000000000000000000001118 107.0
HFD2_k127_2965984_5 alpha/beta hydrolase fold - - - 0.0000000000000005708 81.0
HFD2_k127_2968174_0 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 316.0
HFD2_k127_2968174_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001959 271.0
HFD2_k127_2968174_2 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000002629 211.0
HFD2_k127_2973931_0 Dehydrogenase K00122 - 1.17.1.9 3.929e-250 792.0
HFD2_k127_2973931_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 485.0
HFD2_k127_2973931_2 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 422.0
HFD2_k127_2973931_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 325.0
HFD2_k127_2973931_4 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000005306 250.0
HFD2_k127_2973931_5 serine threonine protein kinase K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000007838 269.0
HFD2_k127_2973931_6 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000248 229.0
HFD2_k127_2973931_7 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000001325 186.0
HFD2_k127_2973931_8 acyl carrier protein K02078 - - 0.00000000000716 72.0
HFD2_k127_2982236_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 374.0
HFD2_k127_2982236_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009167 318.0
HFD2_k127_2982236_2 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001351 242.0
HFD2_k127_2982236_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000005655 127.0
HFD2_k127_2983316_0 Pfam:AmoA K07120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005388 324.0
HFD2_k127_2983316_1 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 302.0
HFD2_k127_2983316_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005087 281.0
HFD2_k127_2988223_0 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 299.0
HFD2_k127_2988223_1 Isochorismatase family K09020 - 3.5.1.110 0.0000000000000000000000000000000000000000000000000000000000000000000000000005612 259.0
HFD2_k127_2988223_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000001244 160.0
HFD2_k127_2988223_3 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.00000000000000000003369 91.0
HFD2_k127_3003460_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 473.0
HFD2_k127_3003460_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 406.0
HFD2_k127_3003460_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 361.0
HFD2_k127_3003460_3 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 297.0
HFD2_k127_3003460_4 Anabaena sensory rhodopsin transducer - - - 0.00000000000000000000000000000000000000000000004284 171.0
HFD2_k127_3003460_5 MAPEG family - - - 0.000000000000000000000000000000000000001843 152.0
HFD2_k127_3003460_6 - - - - 0.00000009377 59.0
HFD2_k127_3014108_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 1.063e-197 626.0
HFD2_k127_3014108_1 Alcohol dehydrogenase GroES-like domain K19745 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 385.0
HFD2_k127_3014108_2 Membrane-associated sensor, integral membrane domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 349.0
HFD2_k127_3014108_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007188 268.0
HFD2_k127_3014108_4 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000000000000000000000000000000000001489 209.0
HFD2_k127_3014108_5 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000004011 151.0
HFD2_k127_3014108_6 transcriptional regulator - - - 0.000000000000000000000005153 104.0
HFD2_k127_3014108_7 Phosphodiester glycosidase - - - 0.00000000000000000000001635 115.0
HFD2_k127_3016623_0 ABC-type Fe3 transport system permease component - - - 2.735e-215 683.0
HFD2_k127_3016623_1 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005523 247.0
HFD2_k127_3055381_0 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 475.0
HFD2_k127_3055381_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 431.0
HFD2_k127_3055381_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009694 376.0
HFD2_k127_3055381_3 PFAM Carbohydrate-selective porin OprB K07267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 379.0
HFD2_k127_3055381_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 332.0
HFD2_k127_3055381_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009077 310.0
HFD2_k127_3055381_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08319 - 1.1.1.411 0.0000000000000000000000000000000000000000000000000000000000000000000000208 252.0
HFD2_k127_3055381_7 - - - - 0.0000000000000000000000000000000000000000000000000000002183 204.0
HFD2_k127_3055381_8 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000002839 91.0
HFD2_k127_3057729_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 602.0
HFD2_k127_3057729_1 Amidase K02433,K21801 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 486.0
HFD2_k127_3057729_2 NMT1/THI5 like K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 416.0
HFD2_k127_3057729_3 Periplasmic binding protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 385.0
HFD2_k127_3057729_4 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 295.0
HFD2_k127_3057729_5 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000436 241.0
HFD2_k127_3057729_6 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000001124 220.0
HFD2_k127_3057729_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000006233 185.0
HFD2_k127_3057729_8 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000003425 161.0
HFD2_k127_3066048_0 COG1138 Cytochrome c biogenesis factor K02198 - - 8.273e-283 890.0
HFD2_k127_3066048_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 435.0
HFD2_k127_3066048_2 COG4235 Cytochrome c biogenesis factor K02200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005615 272.0
HFD2_k127_3066048_3 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000004713 177.0
HFD2_k127_3066048_4 Redoxin K02199 - - 0.000000000000000000000000000000000000000002844 179.0
HFD2_k127_3066048_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000001391 156.0
HFD2_k127_3066048_6 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000001755 101.0
HFD2_k127_3066048_7 Prolyl oligopeptidase family - - - 0.000000000003173 72.0
HFD2_k127_3066048_8 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.0000000002142 63.0
HFD2_k127_3073530_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 551.0
HFD2_k127_3073530_1 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 342.0
HFD2_k127_3073530_2 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009367 313.0
HFD2_k127_3073530_3 COG2030 Acyl dehydratase K17865 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576 4.2.1.55 0.00000000000000000000000000000000000000000000000000005553 194.0
HFD2_k127_3073530_4 Nitronate monooxygenase K00459 - 1.13.12.16 0.000001923 54.0
HFD2_k127_3085604_0 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 374.0
HFD2_k127_3085604_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 341.0
HFD2_k127_3085604_2 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000004215 256.0
HFD2_k127_3085604_4 transferase activity, transferring glycosyl groups - - - 0.0000004768 62.0
HFD2_k127_3085604_5 Bacterial regulatory proteins, tetR family - - - 0.00000886 48.0
HFD2_k127_3094936_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 328.0
HFD2_k127_3094936_1 Phenylacetic acid degradation protein PaaY K08279 - - 0.0000000000000000000000000000000000000000000000000000000000008381 216.0
HFD2_k127_3094936_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000002217 121.0
HFD2_k127_3094936_3 lytic transglycosylase activity K03194,K08307,K08309,K12089 - - 0.0003618 51.0
HFD2_k127_3097638_0 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 309.0
HFD2_k127_3097638_1 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000001272 260.0
HFD2_k127_3097638_2 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000000000001312 197.0
HFD2_k127_309944_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 523.0
HFD2_k127_3104384_0 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 397.0
HFD2_k127_3104384_1 Acyl-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001365 243.0
HFD2_k127_3104384_2 FAD dependent oxidoreductase K02846 - - 0.000004629 49.0
HFD2_k127_3111054_0 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 382.0
HFD2_k127_3111054_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005764 394.0
HFD2_k127_3115061_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 529.0
HFD2_k127_3115061_1 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 359.0
HFD2_k127_3122508_0 COG2913 Small protein A (tmRNA-binding) - - - 0.000000000000000000000003213 109.0
HFD2_k127_3122508_1 transcriptional regulator - - - 0.0000000000000000000004898 103.0
HFD2_k127_3122508_2 - - - - 0.00001807 54.0
HFD2_k127_3128969_0 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 448.0
HFD2_k127_3128969_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000007601 244.0
HFD2_k127_3133589_0 Dehydrogenase E1 component K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 366.0
HFD2_k127_3133589_1 Alternative locus ID K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000005293 186.0
HFD2_k127_3150973_0 PFAM Prokaryotic protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005719 564.0
HFD2_k127_3150973_1 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 345.0
HFD2_k127_3150973_2 Ring hydroxylating alpha subunit (catalytic domain) K00479,K16319 - 1.14.12.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 348.0
HFD2_k127_3150973_3 Ring hydroxylating beta subunit - - - 0.00000000000000000000000000000000001108 141.0
HFD2_k127_3150973_4 4Fe-4S single cluster domain K05337 - - 0.000000009923 59.0
HFD2_k127_3209192_0 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000002137 244.0
HFD2_k127_3209192_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000007445 237.0
HFD2_k127_3209192_2 Protein of unknown function (DUF3303) - - - 0.000000000000000000000005982 102.0
HFD2_k127_3209192_3 PAS domain - - - 0.00000000000007015 83.0
HFD2_k127_3209192_4 PAS domain - - - 0.00000000001029 73.0
HFD2_k127_3262040_0 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000007658 173.0
HFD2_k127_3262040_1 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000008247 149.0
HFD2_k127_3262040_2 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000003171 138.0
HFD2_k127_3266050_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004373 293.0
HFD2_k127_3266050_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001326 271.0
HFD2_k127_3266050_2 transcriptional regulator K05818 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000008533 217.0
HFD2_k127_3266050_3 Rieske [2Fe-2S] domain K18068 - 1.14.12.7 0.0000000000000000000000000000000000000000000000000000007285 201.0
HFD2_k127_3266050_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000001896 171.0
HFD2_k127_3266050_5 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000005913 104.0
HFD2_k127_3266050_6 Rieske 2Fe2S - - - 0.000000000000001446 78.0
HFD2_k127_3275731_0 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 300.0
HFD2_k127_3275731_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 288.0
HFD2_k127_3275731_2 PFAM Methionine synthase vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000003015 189.0
HFD2_k127_3275731_3 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000001843 169.0
HFD2_k127_3276457_0 Domain of unknown function (DUF3463) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 566.0
HFD2_k127_3276457_1 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008337 387.0
HFD2_k127_3287607_0 Aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 1.334e-217 685.0
HFD2_k127_3287607_1 Phosphoesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 522.0
HFD2_k127_3287607_2 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 492.0
HFD2_k127_3287607_3 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 306.0
HFD2_k127_3287607_4 Pentapeptide repeats (9 copies) - - - 0.00000000000000000002184 100.0
HFD2_k127_3288949_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 345.0
HFD2_k127_3288949_1 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001243 284.0
HFD2_k127_3288949_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000014 84.0
HFD2_k127_3288949_3 PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit - - - 0.0001993 51.0
HFD2_k127_3295968_0 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004871 526.0
HFD2_k127_3295968_1 COG0524 Sugar kinases, ribokinase family K00847,K00856 - 2.7.1.20,2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 433.0
HFD2_k127_3295968_2 Carboxylesterase family K03929 - - 0.0000000000000000000009058 98.0
HFD2_k127_3295968_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000001798 100.0
HFD2_k127_3303171_0 de-polymerase K05973 - 3.1.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 357.0
HFD2_k127_3303171_1 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 349.0
HFD2_k127_3303171_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 321.0
HFD2_k127_3303171_3 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.0000000000000000000000000000000000000000000000000000000001308 213.0
HFD2_k127_3303171_4 protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000000007327 190.0
HFD2_k127_3303171_5 His Kinase A (phosphoacceptor) domain K15011 - 2.7.13.3 0.000000000000000000000000000006836 123.0
HFD2_k127_3305157_0 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 292.0
HFD2_k127_3305157_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000306 151.0
HFD2_k127_3319182_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 442.0
HFD2_k127_3319182_1 Extracellular ligand-binding receptor K01999 - - 0.000000000000000003638 89.0
HFD2_k127_3333995_0 Domain of unknown function (DUF3362) - - - 2.519e-207 651.0
HFD2_k127_3333995_1 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 - 3.2.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 495.0
HFD2_k127_3333995_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000387 226.0
HFD2_k127_3333995_3 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000008486 203.0
HFD2_k127_3338309_0 Oxidoreductase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 447.0
HFD2_k127_3338309_1 PFAM Protein kinase domain K08884 - 2.7.11.1 0.00000000000004825 76.0
HFD2_k127_3345571_0 Glycosyl transferase 4-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 452.0
HFD2_k127_3345571_1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase K02851,K13007 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001476 289.0
HFD2_k127_3345571_2 Histidine kinase K07716 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000531 282.0
HFD2_k127_3345571_3 Histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000104 282.0
HFD2_k127_3345571_4 Polysaccharide biosynthesis protein K13013 - - 0.000000000000000000000000000000000000000000000000000000000000000004504 233.0
HFD2_k127_3345571_5 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000002767 171.0
HFD2_k127_3346865_0 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007654 440.0
HFD2_k127_3346865_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 410.0
HFD2_k127_3346865_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000006067 173.0
HFD2_k127_3346865_3 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000003736 110.0
HFD2_k127_3346865_4 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000002877 59.0
HFD2_k127_3353347_0 PFAM Diacylglycerol kinase, catalytic - - - 0.0000000000000000000000000000000000000000000000000003367 198.0
HFD2_k127_3353347_1 - - - - 0.000000000000000000000000000000000000000234 155.0
HFD2_k127_3353347_2 Fatty acid desaturase - - - 0.00000000000000000000000001655 111.0
HFD2_k127_3353347_3 PFAM glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000007456 93.0
HFD2_k127_3373887_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007711 533.0
HFD2_k127_3373887_1 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 319.0
HFD2_k127_3373887_2 Pfam Cupin K00450,K11948 - 1.13.11.38,1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002489 289.0
HFD2_k127_3373887_3 Protein of unknown function (DUF423) - - - 0.000000000000000000000000009453 113.0
HFD2_k127_3373887_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000001568 109.0
HFD2_k127_3373887_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000003624 77.0
HFD2_k127_3373887_6 Outer membrane protein beta-barrel domain - - - 0.0000000002494 69.0
HFD2_k127_3385119_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 542.0
HFD2_k127_3385119_1 Sporulation related domain - - - 0.000000000000000003763 95.0
HFD2_k127_340274_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 3e-218 699.0
HFD2_k127_340274_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 511.0
HFD2_k127_340274_2 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 386.0
HFD2_k127_340274_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 320.0
HFD2_k127_340274_4 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000002958 172.0
HFD2_k127_3409259_0 Cupin domain K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 485.0
HFD2_k127_3409259_1 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000003353 95.0
HFD2_k127_3409259_2 Protein of unknown function (DUF1326) - - - 0.000000000007962 67.0
HFD2_k127_3409259_3 - - - - 0.0003382 52.0
HFD2_k127_3409317_0 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000227 279.0
HFD2_k127_3409317_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000531 250.0
HFD2_k127_3409317_2 Creatinine amidohydrolase - - - 0.0000000000000000000000000000000000000000000002294 174.0
HFD2_k127_3409317_3 Protein conserved in bacteria - - - 0.0000000000000000000004145 108.0
HFD2_k127_3427540_0 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 539.0
HFD2_k127_3427540_1 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 357.0
HFD2_k127_3427540_2 Chaperone SurA K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000002733 227.0
HFD2_k127_3427540_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000003501 171.0
HFD2_k127_3427540_4 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000001574 111.0
HFD2_k127_3434975_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1109.0
HFD2_k127_3434975_1 peptidylprolyl isomerase K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 302.0
HFD2_k127_3434975_2 - - - - 0.000000000000000000000000000000000007816 147.0
HFD2_k127_3434975_3 Protein conserved in bacteria K21600 - - 0.00000000000000000000000000000000205 131.0
HFD2_k127_3434975_4 LTXXQ motif family protein - - - 0.000000000000001902 83.0
HFD2_k127_3434975_5 Predicted integral membrane protein (DUF2282) - - - 0.00000000005846 74.0
HFD2_k127_3471575_0 OstA-like protein K09774 - - 0.000000000000000000000000000000000000000000000000000000002649 211.0
HFD2_k127_3471575_1 ABC transporter, ATP-binding protein K06861 - - 0.00000000000000000000000000000000000009594 148.0
HFD2_k127_3471575_2 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000000006044 130.0
HFD2_k127_3490185_0 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 5.164e-312 966.0
HFD2_k127_3490185_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000001012 250.0
HFD2_k127_3500384_0 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 297.0
HFD2_k127_3500384_1 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 290.0
HFD2_k127_3500527_0 - - - - 0.000000005351 64.0
HFD2_k127_3531935_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 445.0
HFD2_k127_3531935_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 442.0
HFD2_k127_3531935_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000698 398.0
HFD2_k127_3531935_3 chaperone TorD - - - 0.0000000000000000000000000000000000000000000000000000000000000000004914 237.0
HFD2_k127_3531935_4 Biotin/lipoate A/B protein ligase family - - - 0.00000000000000000000000000000000000002766 153.0
HFD2_k127_3531935_5 - - - - 0.00000000000000000000000000000000001104 145.0
HFD2_k127_3531935_6 Protein of unknown function (DUF3305) - - - 0.000000000000000000000002961 110.0
HFD2_k127_3531935_7 Protein of unknown function (DUF3306) - - - 0.000000000000000000000239 105.0
HFD2_k127_3531935_8 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000004059 85.0
HFD2_k127_3531935_9 TIGRFAM formate dehydrogenase region TAT target - - - 0.000003791 59.0
HFD2_k127_3537167_0 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 422.0
HFD2_k127_3537167_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 414.0
HFD2_k127_3537167_2 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000001871 160.0
HFD2_k127_3539923_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 402.0
HFD2_k127_3539923_1 Benzoate membrane transport protein K05782 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 374.0
HFD2_k127_3539923_10 Class II aldolase adducin family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 291.0
HFD2_k127_3539923_11 Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 281.0
HFD2_k127_3539923_12 Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000000000000000000000000000000000000007271 198.0
HFD2_k127_3539923_13 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000004104 142.0
HFD2_k127_3539923_14 Terminase small subunit K07474 - - 0.000372 51.0
HFD2_k127_3539923_2 COG2513 PEP phosphonomutase and related enzymes K20454 - 4.1.3.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005999 349.0
HFD2_k127_3539923_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 366.0
HFD2_k127_3539923_4 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 344.0
HFD2_k127_3539923_5 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 341.0
HFD2_k127_3539923_6 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 339.0
HFD2_k127_3539923_7 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009587 319.0
HFD2_k127_3539923_8 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 297.0
HFD2_k127_3539923_9 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 309.0
HFD2_k127_3544491_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 8.486e-197 625.0
HFD2_k127_3544491_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000003877 168.0
HFD2_k127_3544491_2 epimerase dehydratase K08679 - 5.1.3.6 0.00000000000000000000000001054 112.0
HFD2_k127_3551075_0 PFAM Glyoxalase bleomycin resistance protein dioxygenase K00446 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 358.0
HFD2_k127_3551075_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000004558 213.0
HFD2_k127_3551075_2 Sel1-like repeats. K07126 - - 0.000000000000000000000000000000002072 144.0
HFD2_k127_3551075_3 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000002275 129.0
HFD2_k127_3559344_0 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 508.0
HFD2_k127_3559344_1 reductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 432.0
HFD2_k127_3559344_2 Aspartate tyrosine aromatic aminotransferase - - - 0.000000000000000000000000000000000000000000000000000004731 192.0
HFD2_k127_3563050_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000001615 235.0
HFD2_k127_3563050_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000007517 175.0
HFD2_k127_3563050_2 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000008217 176.0
HFD2_k127_3563050_3 UreE urease accessory protein, C-terminal domain K03649 - 3.2.2.28 0.000000000000000000000000000000000181 140.0
HFD2_k127_3563050_4 - - - - 0.00000000000000000000000000000000148 131.0
HFD2_k127_3563050_5 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000000005596 131.0
HFD2_k127_3563050_6 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000001027 117.0
HFD2_k127_3563050_7 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000009446 68.0
HFD2_k127_3563050_8 Belongs to the 'phage' integrase family - - - 0.00000001825 62.0
HFD2_k127_356789_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.878e-238 747.0
HFD2_k127_356789_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 587.0
HFD2_k127_356789_10 Alpha/beta hydrolase family - - - 0.000002066 54.0
HFD2_k127_356789_11 transport - - - 0.000003333 58.0
HFD2_k127_356789_2 Isocitrate/isopropylmalate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 532.0
HFD2_k127_356789_3 COG3839 ABC-type sugar transport systems, ATPase components - - - 0.00000000000000000000000000000000000000000000000000000001585 200.0
HFD2_k127_356789_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000006739 170.0
HFD2_k127_356789_5 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000000001503 149.0
HFD2_k127_356789_6 protein possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000001057 135.0
HFD2_k127_356789_7 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000003205 128.0
HFD2_k127_356789_8 transport - - - 0.0000000000000005699 86.0
HFD2_k127_356789_9 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000001067 70.0
HFD2_k127_3571645_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1047.0
HFD2_k127_3571645_1 Sodium/hydrogen exchanger family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002772 258.0
HFD2_k127_3571645_2 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000003868 223.0
HFD2_k127_3571645_3 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000009475 176.0
HFD2_k127_3571645_4 CBS domain - - - 0.000000000000000000000000000000000006507 141.0
HFD2_k127_3571645_5 COG1278 Cold shock proteins K03704 - - 0.0000000000000000000000016 103.0
HFD2_k127_3571645_6 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000002056 104.0
HFD2_k127_3593887_0 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000001964 122.0
HFD2_k127_3593887_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000006153 75.0
HFD2_k127_3601224_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 1.752e-255 803.0
HFD2_k127_3601224_1 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.0000000000000000000000000000000000000000000000000000000000000000006735 234.0
HFD2_k127_3601562_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006993 284.0
HFD2_k127_3601562_1 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007666 276.0
HFD2_k127_3601562_2 endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000001199 181.0
HFD2_k127_3601562_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000006191 170.0
HFD2_k127_3601562_4 SnoaL-like domain - - - 0.0000000000000000000000000000000000001059 147.0
HFD2_k127_3601562_5 Histidine phosphatase superfamily (branch 1) - - - 0.00000000000000000000000000001293 131.0
HFD2_k127_3601562_6 tetR family' - - - 0.000000000000000000000003386 107.0
HFD2_k127_3605446_0 CHASE2 K01768 - 4.6.1.1 2.274e-195 632.0
HFD2_k127_3605446_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 604.0
HFD2_k127_3608361_0 transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006952 278.0
HFD2_k127_3608361_1 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000004392 248.0
HFD2_k127_3611094_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 336.0
HFD2_k127_3611094_1 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000012 252.0
HFD2_k127_3613289_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 472.0
HFD2_k127_3613289_1 Dehydrogenase E1 component K00164 - 1.2.4.2 0.00000000000000000000000000000000000000000000000000006536 194.0
HFD2_k127_3616240_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 487.0
HFD2_k127_3616240_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 450.0
HFD2_k127_3616240_2 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000008969 188.0
HFD2_k127_3620777_0 Belongs to the peptidase S1C family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 426.0
HFD2_k127_3620777_1 structural constituent of ribosome K02879 - - 0.000000000000000000000000000000000000000000000000000000001813 203.0
HFD2_k127_3620777_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000278 188.0
HFD2_k127_3620777_3 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 0.000001693 61.0
HFD2_k127_3623679_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 462.0
HFD2_k127_3623679_1 Bactoprenol glucosyl transferase K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 373.0
HFD2_k127_3623679_10 - - - - 0.00000000001295 77.0
HFD2_k127_3623679_11 dna methylase K00571,K07316 - 2.1.1.72 0.00007549 48.0
HFD2_k127_3623679_2 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005907 295.0
HFD2_k127_3623679_3 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002596 265.0
HFD2_k127_3623679_4 - - - - 0.000000000000000000000000000000000000000000001214 183.0
HFD2_k127_3623679_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000000000000009575 153.0
HFD2_k127_3623679_6 Peptidase C13 family - - - 0.00000000000000000000000000000000000000211 155.0
HFD2_k127_3623679_7 RHS Repeat - - - 0.00000000000000000000000000000000006653 137.0
HFD2_k127_3623679_8 transcriptional regulator, MerR - - - 0.000000000000000000000000000001079 131.0
HFD2_k127_3623679_9 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.0000000000005139 73.0
HFD2_k127_3625305_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 540.0
HFD2_k127_3625305_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000136 186.0
HFD2_k127_3625305_2 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000000000000002524 173.0
HFD2_k127_3625305_3 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000001175 139.0
HFD2_k127_3625305_4 Trypsin-like peptidase domain - - - 0.000000000000000000000000000002799 134.0
HFD2_k127_3625305_5 Protein of unknown function (FYDLN_acid) - - - 0.000000001011 70.0
HFD2_k127_3625305_6 - - - - 0.00001126 49.0
HFD2_k127_3626251_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000665 553.0
HFD2_k127_3626251_1 Acetyltransferase (GNAT) family - - - 0.00000000000000000003905 99.0
HFD2_k127_3626251_2 PFAM GCN5-related N-acetyltransferase - - - 0.0000006466 55.0
HFD2_k127_3632513_0 Belongs to the LDH2 MDH2 oxidoreductase family K13574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 423.0
HFD2_k127_3632513_1 Coenzyme A transferase K01031 - 2.8.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008416 338.0
HFD2_k127_3632513_2 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000002536 166.0
HFD2_k127_3632513_3 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01032 - 2.8.3.6 0.000000000000000000000000000000000000001153 160.0
HFD2_k127_3632513_4 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000004955 111.0
HFD2_k127_3636820_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 5.451e-207 655.0
HFD2_k127_3636820_1 cytochrome c oxidase K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 386.0
HFD2_k127_3636820_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006896 249.0
HFD2_k127_3636820_3 SURF1-like protein K14998 - - 0.000000000000000000000000000000000000000000000000000000000000000000001702 244.0
HFD2_k127_3636820_4 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.000000000000000000000000000000000000000000000000000002423 202.0
HFD2_k127_3636820_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000004706 169.0
HFD2_k127_3636820_6 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000000000000000002586 169.0
HFD2_k127_363889_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 422.0
HFD2_k127_363889_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 349.0
HFD2_k127_363889_2 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.00000000000000000000000000000000000002878 153.0
HFD2_k127_3641187_0 Poly-beta-hydroxybutyrate polymerase N terminal K03821 - - 4.271e-218 701.0
HFD2_k127_3641187_1 FAD binding domain K00104,K05797 - 1.1.3.15,1.17.99.1 5.658e-199 634.0
HFD2_k127_3641187_2 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006911 454.0
HFD2_k127_3641187_3 protein-L-isoaspartate O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000001395 261.0
HFD2_k127_3641187_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000002972 156.0
HFD2_k127_3641187_5 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000008619 124.0
HFD2_k127_3644927_0 Branched-chain amino acid ATP-binding cassette transporter - - - 2.73e-246 773.0
HFD2_k127_3644927_1 ABC transporter substrate-binding protein K02035 - - 3.468e-213 674.0
HFD2_k127_3644927_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 545.0
HFD2_k127_3644927_3 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 515.0
HFD2_k127_3644927_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 398.0
HFD2_k127_3644927_5 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 389.0
HFD2_k127_3644927_6 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 305.0
HFD2_k127_3644927_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K08234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001575 275.0
HFD2_k127_3644927_8 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000002161 207.0
HFD2_k127_3644927_9 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000009208 157.0
HFD2_k127_3648070_0 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000007244 104.0
HFD2_k127_3648070_1 - - - - 0.000004253 54.0
HFD2_k127_365029_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 479.0
HFD2_k127_365029_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 473.0
HFD2_k127_365029_10 Cold shock K03704 - - 0.00000000000000000000000001106 109.0
HFD2_k127_365029_11 transcriptional regulator - - - 0.0000000000000000001814 92.0
HFD2_k127_365029_12 transcriptional regulator - - - 0.0000000000000711 75.0
HFD2_k127_365029_2 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 385.0
HFD2_k127_365029_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 372.0
HFD2_k127_365029_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001451 265.0
HFD2_k127_365029_5 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001921 263.0
HFD2_k127_365029_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005022 253.0
HFD2_k127_365029_7 PFAM Fatty acid desaturase K00508 - 1.14.19.3 0.0000000000000000000000000000000000000000000000000000000001357 218.0
HFD2_k127_365029_8 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000001789 168.0
HFD2_k127_365029_9 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000003849 117.0
HFD2_k127_3656742_0 Oxidoreductase - - - 2.642e-197 621.0
HFD2_k127_3656742_1 Dihydrodipicolinate synthetase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 550.0
HFD2_k127_3656742_2 PFAM regulatory protein TetR - - - 0.00000000000000000000000000000000000000000000000000000000008638 210.0
HFD2_k127_3656742_3 Protein of unknown function (DUF993) - - - 0.00000000000000000000000000000000000000000000000000003071 203.0
HFD2_k127_368053_0 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000003659 164.0
HFD2_k127_368053_1 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000005052 115.0
HFD2_k127_368053_2 - - - - 0.000000008257 70.0
HFD2_k127_368053_3 - - - - 0.00000002359 65.0
HFD2_k127_3682215_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 446.0
HFD2_k127_3682215_1 COG4531 ABC-type Zn2 transport system, periplasmic component surface adhesin K09815 - - 0.000000000000000000000000000000000000000000000000005368 186.0
HFD2_k127_3682215_2 transport system, periplasmic component - - - 0.0000000001914 63.0
HFD2_k127_370135_0 AcrB/AcrD/AcrF family - - - 0.0 1451.0
HFD2_k127_370135_1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 2.557e-218 683.0
HFD2_k127_370135_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 384.0
HFD2_k127_370135_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 306.0
HFD2_k127_370135_4 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000002403 241.0
HFD2_k127_370135_5 Protein of unknown function (DUF2892) - - - 0.0000000000000000008825 94.0
HFD2_k127_3701398_0 Belongs to the peptidase S16 family - - - 8.694e-205 653.0
HFD2_k127_3701398_1 Domain of unknown function DUF87 K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 480.0
HFD2_k127_3701398_2 Histidine kinase K07716 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000007166 226.0
HFD2_k127_3701398_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000001513 174.0
HFD2_k127_3701398_4 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000003842 165.0
HFD2_k127_3701398_5 Papain-like cysteine protease AvrRpt2 - - - 0.0000000000000000000000000000000000001486 148.0
HFD2_k127_3701398_6 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000001979 111.0
HFD2_k127_3701398_7 endoribonuclease L-PSP - - - 0.000000000000000000000003504 108.0
HFD2_k127_37026_0 TIGRFAM aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein K15553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007218 396.0
HFD2_k127_37026_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 315.0
HFD2_k127_37026_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 318.0
HFD2_k127_37026_3 ABC transporter K15555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001687 301.0
HFD2_k127_37026_4 protein conserved in bacteria K09938 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001279 274.0
HFD2_k127_37026_5 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006291 246.0
HFD2_k127_37026_6 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.000000000000000000000000000000000000000000000000000000005286 201.0
HFD2_k127_37026_7 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000001625 209.0
HFD2_k127_3716971_0 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 550.0
HFD2_k127_3716971_1 RQC K03654 GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 0.00000000000000000000000000000000000000000000004086 179.0
HFD2_k127_3736187_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009659 489.0
HFD2_k127_3736187_1 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 353.0
HFD2_k127_3736187_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000001954 109.0
HFD2_k127_3743664_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 572.0
HFD2_k127_3743664_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000172 209.0
HFD2_k127_3754382_0 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007712 363.0
HFD2_k127_3754382_1 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000004555 172.0
HFD2_k127_3754382_2 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.000000000000000002941 90.0
HFD2_k127_3756558_0 Glutamine amidotransferase domain K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.947e-211 666.0
HFD2_k127_3756558_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 489.0
HFD2_k127_3756558_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 341.0
HFD2_k127_3768127_0 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.0000000000000000000000000000000000000000000005692 171.0
HFD2_k127_3768127_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000001585 138.0
HFD2_k127_3768127_2 NMT1-like family - - - 0.000000000000000000000219 109.0
HFD2_k127_3771928_0 AMP-binding enzyme K12508 - 6.2.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 567.0
HFD2_k127_3771928_1 Thiolase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 505.0
HFD2_k127_3771928_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 422.0
HFD2_k127_3771928_3 enoyl-CoA hydratase K20036 - 4.2.1.155 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 298.0
HFD2_k127_3771928_4 Aspartyl/Asparaginyl beta-hydroxylase K12979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001086 286.0
HFD2_k127_3771928_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000001184 190.0
HFD2_k127_3771928_6 MaoC like domain - - - 0.00000000000000000001131 106.0
HFD2_k127_3771928_7 acetyltransferase K00657,K09962 - 2.3.1.57 0.0000000000000006785 83.0
HFD2_k127_3771928_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000004306 55.0
HFD2_k127_3780538_0 BON domain - - - 0.000000000000000000000000000000000000000000000000000001422 200.0
HFD2_k127_3780538_1 SpoU rRNA Methylase family - - - 0.00000000000000000000000000000000000000000001152 164.0
HFD2_k127_3780538_2 Protein of unknown function (DUF1272) - - - 0.000000000000000004263 84.0
HFD2_k127_3780538_3 invasion associated locus B - - - 0.0000000000003521 78.0
HFD2_k127_3781969_0 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 413.0
HFD2_k127_3781969_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000848 220.0
HFD2_k127_3782645_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 426.0
HFD2_k127_3782645_1 Polyhydroxyalkanoate synthesis repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000002655 225.0
HFD2_k127_3783019_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 3.236e-262 815.0
HFD2_k127_3783019_1 C4-dicarboxylate transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 510.0
HFD2_k127_3783019_10 Domain of unknown function (DUF1330) - - - 0.0000000000000000000001523 100.0
HFD2_k127_3783019_11 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000002751 103.0
HFD2_k127_3783019_12 Thioesterase-like superfamily K01075 - 3.1.2.23 0.0000000000000000002397 97.0
HFD2_k127_3783019_13 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000005706 67.0
HFD2_k127_3783019_2 3,4-dihydroxyphenylacetate 2,3-dioxygenase K00455 - 1.13.11.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 423.0
HFD2_k127_3783019_3 belongs to the aldehyde dehydrogenase family K00130,K00151 - 1.2.1.60,1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 402.0
HFD2_k127_3783019_4 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 387.0
HFD2_k127_3783019_5 Class II aldolase adducin family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 390.0
HFD2_k127_3783019_6 Trap-type c4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 301.0
HFD2_k127_3783019_7 4Fe-4S dicluster domain K11473 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 0.0000000000000000000000000000000000000000000000000000000000006808 214.0
HFD2_k127_3783019_8 PFAM O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000005995 211.0
HFD2_k127_3783019_9 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000001203 111.0
HFD2_k127_3794272_0 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004122 244.0
HFD2_k127_3794272_1 glyoxalase K08234 - - 0.0000000000000000000000000000000000000000000000000000000000002619 219.0
HFD2_k127_3794272_2 Receptor family ligand binding region K01999 - - 0.0000000000003174 72.0
HFD2_k127_3799279_0 Belongs to the thiolase family K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 601.0
HFD2_k127_3799279_1 2-deoxycytidine 5-triphosphate deaminase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 429.0
HFD2_k127_3813369_0 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 541.0
HFD2_k127_3813369_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 362.0
HFD2_k127_3813369_2 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009583 362.0
HFD2_k127_3813369_3 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008666 295.0
HFD2_k127_3813369_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000001038 258.0
HFD2_k127_3813369_5 Tripartite tricarboxylate transporter TctB family - - - 0.00001003 54.0
HFD2_k127_3833189_0 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 483.0
HFD2_k127_3833189_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 406.0
HFD2_k127_3833189_2 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006963 273.0
HFD2_k127_3833189_3 Belongs to the HesB IscA family K15724 - - 0.0000000000000000000000000000000002829 134.0
HFD2_k127_3833189_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000001466 122.0
HFD2_k127_3833189_5 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000003542 91.0
HFD2_k127_3833189_6 PAS domain - - - 0.0000000000000001212 89.0
HFD2_k127_3833189_7 Terminase small subunit K07474 - - 0.0004328 50.0
HFD2_k127_3835983_0 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 300.0
HFD2_k127_3835983_1 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000000004396 159.0
HFD2_k127_3835983_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000001401 149.0
HFD2_k127_3843923_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 0.0 1349.0
HFD2_k127_3843923_1 Flavodoxin-like fold K03923,K11748 - - 0.000000000000000000000000000000000000000000000000000009968 193.0
HFD2_k127_3843923_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000000191 170.0
HFD2_k127_3843923_3 Flavodoxin - - - 0.000000000000000000000000003579 118.0
HFD2_k127_3843923_4 FR47-like protein - - - 0.0000000000000000001601 91.0
HFD2_k127_3847282_0 Bacterial protein of unknown function (DUF839) K07093 - - 1.002e-266 832.0
HFD2_k127_3847282_1 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000002153 192.0
HFD2_k127_386782_0 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 524.0
HFD2_k127_386782_1 formamidase K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 469.0
HFD2_k127_386782_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 462.0
HFD2_k127_386782_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006895 359.0
HFD2_k127_386782_4 KR domain K00059,K07535 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 304.0
HFD2_k127_386782_5 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000042 250.0
HFD2_k127_386782_6 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000001631 177.0
HFD2_k127_386782_7 CAAX amino terminal protease family protein K07052 - - 0.0000000000274 73.0
HFD2_k127_386782_8 GDP-mannose 4,6 dehydratase K02377 - 1.1.1.271 0.000000002436 59.0
HFD2_k127_387284_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 307.0
HFD2_k127_387284_1 COG0402 Cytosine deaminase and related metal-dependent hydrolases - - - 0.00000000000000000000000000000004938 132.0
HFD2_k127_3880434_0 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 473.0
HFD2_k127_3880434_1 Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 470.0
HFD2_k127_3880434_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 336.0
HFD2_k127_3885832_0 FAD dependent oxidoreductase - - - 0.0 1082.0
HFD2_k127_3885832_1 Na+/Pi-cotransporter K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 584.0
HFD2_k127_3885832_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000005288 72.0
HFD2_k127_3910637_0 Histidine biosynthesis protein K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 430.0
HFD2_k127_3910637_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 326.0
HFD2_k127_3910637_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.0000000000000000000000000000000000000000000000005139 177.0
HFD2_k127_3910637_3 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000007157 178.0
HFD2_k127_3910637_4 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.00000000000000000000000000000000002148 137.0
HFD2_k127_3910637_5 Dodecin K09165 - - 0.000000000000000000001429 107.0
HFD2_k127_3915474_0 HlyD membrane-fusion protein of T1SS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 360.0
HFD2_k127_3915474_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000001191 164.0
HFD2_k127_3915474_2 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 0.00000000000000000002021 93.0
HFD2_k127_3915474_3 RmuC family K09760 - - 0.0000006857 53.0
HFD2_k127_3926378_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1464.0
HFD2_k127_3926378_1 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 601.0
HFD2_k127_3926378_2 Mitochondrial fission ELM1 K07276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 295.0
HFD2_k127_3926378_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000001162 234.0
HFD2_k127_3926378_4 helix_turn_helix ASNC type - - - 0.0000000000000000000000000000000000000000000000000000000000000000002957 234.0
HFD2_k127_3926378_5 Ankyrin repeats (many copies) - - - 0.000000000000000000000000000000000003285 155.0
HFD2_k127_3926378_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000001879 93.0
HFD2_k127_3926378_7 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000001131 66.0
HFD2_k127_3926378_8 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000000004342 63.0
HFD2_k127_3928576_0 (ABC) transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 308.0
HFD2_k127_3928576_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 293.0
HFD2_k127_3928576_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000002383 133.0
HFD2_k127_393678_0 ABC-type multidrug transport system, ATPase and permease K06147,K11085 - - 5.197e-202 647.0
HFD2_k127_393678_1 3-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 404.0
HFD2_k127_393678_2 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000997 332.0
HFD2_k127_393678_3 Tyrosine phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006644 264.0
HFD2_k127_393678_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000198 250.0
HFD2_k127_393678_5 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000001144 188.0
HFD2_k127_393678_6 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000008578 154.0
HFD2_k127_393678_7 DNA-binding transcription factor activity - - - 0.00000000000000000000000003786 115.0
HFD2_k127_393678_8 modulator of DNA gyrase K03592 - - 0.0000000001042 61.0
HFD2_k127_393678_9 Regulator of ribonuclease activity B - - - 0.00003115 53.0
HFD2_k127_397511_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 305.0
HFD2_k127_397511_1 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 299.0
HFD2_k127_397511_2 PFAM Penicillin binding protein transpeptidase domain K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000008463 259.0
HFD2_k127_4001228_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 492.0
HFD2_k127_4001228_1 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 434.0
HFD2_k127_4001228_2 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 400.0
HFD2_k127_4001228_3 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000115 202.0
HFD2_k127_4001228_4 - - - - 0.0000000000000000000000000000000000000000000000000000001044 205.0
HFD2_k127_4001228_5 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000001709 140.0
HFD2_k127_4001228_6 - - - - 0.000000000000000002348 93.0
HFD2_k127_4044255_0 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 587.0
HFD2_k127_4044255_1 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000003372 218.0
HFD2_k127_4044255_2 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000000000000000000000000000000000000005378 198.0
HFD2_k127_4044255_3 - - - - 0.0000000000000000000000000000000000000000000408 168.0
HFD2_k127_4054243_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 336.0
HFD2_k127_4054243_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000494 280.0
HFD2_k127_4054243_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000001448 93.0
HFD2_k127_4059693_0 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003695 417.0
HFD2_k127_4059693_1 Phytanoyl-CoA dioxygenase (PhyH) K00477 - 1.14.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 359.0
HFD2_k127_4059693_2 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000005093 166.0
HFD2_k127_4059693_3 NADPH-dependent FMN reductase - - - 0.000000000438 71.0
HFD2_k127_4062971_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 285.0
HFD2_k127_4062971_1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000000000000000000000000408 148.0
HFD2_k127_4062971_2 Domain of Unknown Function (DUF350) K08989 - - 0.00000000000000000000000000000000001417 140.0
HFD2_k127_4070142_0 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 503.0
HFD2_k127_4070142_1 Bacterial protein of unknown function (DUF839) K07093 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 439.0
HFD2_k127_4070142_2 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000005459 254.0
HFD2_k127_4070142_3 DNA repair protein MmcB-like - - - 0.00000000000000000000000000000000000002484 149.0
HFD2_k127_4076927_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000001362 224.0
HFD2_k127_4076927_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000009193 166.0
HFD2_k127_4076927_2 response regulator - - - 0.00000000000002093 77.0
HFD2_k127_4076927_3 Histidine kinase K00936 - 2.7.13.3 0.00000006275 57.0
HFD2_k127_4076927_4 Bacterial protein of unknown function (DUF883) - - - 0.0000008539 55.0
HFD2_k127_4080579_0 PBP superfamily domain K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 482.0
HFD2_k127_4080579_1 Binding-protein-dependent transport system inner membrane component K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 436.0
HFD2_k127_4080579_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 409.0
HFD2_k127_4080579_3 phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 372.0
HFD2_k127_4080579_4 signal transduction histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 325.0
HFD2_k127_4080579_5 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0007745 42.0
HFD2_k127_4092733_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 399.0
HFD2_k127_4092733_1 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007479 388.0
HFD2_k127_4092733_2 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000009474 203.0
HFD2_k127_4116418_0 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005659 291.0
HFD2_k127_4116418_1 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001789 276.0
HFD2_k127_4116418_2 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000001425 147.0
HFD2_k127_4116418_3 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000006063 103.0
HFD2_k127_4134027_0 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000006536 146.0
HFD2_k127_4134027_1 - catabolite gene activator and regulatory subunit of cAMP-dependent protein K01420,K15861 - - 0.0000000000000000000000000000001788 133.0
HFD2_k127_4134027_2 Diguanylate cyclase with PAS PAC and GAF sensors K07315 - 3.1.3.3 0.00000000000000000000000897 105.0
HFD2_k127_4134027_3 TfoX N-terminal domain - - - 0.0000000000000002196 87.0
HFD2_k127_4134027_4 Response regulator, receiver - - - 0.0000003963 57.0
HFD2_k127_4141414_0 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 1.691e-274 861.0
HFD2_k127_4141414_1 nucleotide-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 475.0
HFD2_k127_4141414_2 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 446.0
HFD2_k127_4141414_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 301.0
HFD2_k127_4141414_4 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000004575 186.0
HFD2_k127_4141414_5 Transposase DDE domain - - - 0.0000000000000000000000000000000003638 137.0
HFD2_k127_4141414_6 Dehydratase - - - 0.000000000000000000000000000000001079 137.0
HFD2_k127_4141414_7 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000000000105 109.0
HFD2_k127_4141414_8 helix_turn_helix isocitrate lyase regulation K13641 - - 0.000000000000000000000277 101.0
HFD2_k127_4141414_9 - - - - 0.00000000000000003234 83.0
HFD2_k127_4143951_0 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 474.0
HFD2_k127_4143951_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 345.0
HFD2_k127_4143951_2 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 310.0
HFD2_k127_4143951_3 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000007904 227.0
HFD2_k127_4143951_4 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000004956 222.0
HFD2_k127_4143951_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000001459 202.0
HFD2_k127_4143951_6 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000004632 152.0
HFD2_k127_4143951_7 2-keto-4-pentenoate hydratase K18364 - 4.2.1.132,4.2.1.80 0.000000000000000000000000000002733 130.0
HFD2_k127_4143951_8 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000047 126.0
HFD2_k127_4143951_9 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.0000000003234 61.0
HFD2_k127_4146757_0 4Fe-4S dicluster domain - - - 0.0 1060.0
HFD2_k127_4146757_1 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007496 383.0
HFD2_k127_4147866_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1093.0
HFD2_k127_4147866_1 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 306.0
HFD2_k127_4172167_0 COG0451 Nucleoside-diphosphate-sugar epimerases K17947 - 5.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009015 340.0
HFD2_k127_4172167_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 295.0
HFD2_k127_4172167_2 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002658 248.0
HFD2_k127_4172167_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000001635 172.0
HFD2_k127_4172167_4 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000001245 125.0
HFD2_k127_4172167_5 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.000000000000003122 78.0
HFD2_k127_4172167_6 Resolvase, N terminal domain - - - 0.000001487 57.0
HFD2_k127_4183350_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1330.0
HFD2_k127_4183350_1 Binding-protein-dependent transport system inner membrane component K02011 - - 1.097e-242 763.0
HFD2_k127_4183350_2 MmgE/PrpD family - - - 9.333e-198 653.0
HFD2_k127_4183350_3 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 588.0
HFD2_k127_4183350_4 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 520.0
HFD2_k127_4183350_5 TOBE domain K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 499.0
HFD2_k127_4183350_6 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 375.0
HFD2_k127_4183350_7 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 346.0
HFD2_k127_4183350_8 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 286.0
HFD2_k127_4183350_9 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000009244 208.0
HFD2_k127_4211843_0 PFAM ABC transporter related K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 359.0
HFD2_k127_4211843_1 Aldehyde oxidase and xanthine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001175 251.0
HFD2_k127_4211843_2 PFAM Branched-chain amino acid transport system permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000002781 245.0
HFD2_k127_4211843_3 leucyl aminopeptidase, aminopeptidase T K18028 - 1.13.11.9 0.000000000000000000000000000000000000000000000000000000000000000002024 248.0
HFD2_k127_4211843_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000003157 241.0
HFD2_k127_4211843_5 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000299 226.0
HFD2_k127_4211843_6 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.00000000000000000000000000000000000000000000000001856 183.0
HFD2_k127_4211843_7 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000001952 164.0
HFD2_k127_4211843_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000002219 163.0
HFD2_k127_4212808_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 449.0
HFD2_k127_4212808_1 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003614 284.0
HFD2_k127_4217078_0 MBOAT, membrane-bound O-acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 438.0
HFD2_k127_4217078_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001043 261.0
HFD2_k127_4217078_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000005645 169.0
HFD2_k127_4237219_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006974 549.0
HFD2_k127_4237219_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 362.0
HFD2_k127_4237219_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000007741 244.0
HFD2_k127_4237219_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000004565 165.0
HFD2_k127_426764_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 422.0
HFD2_k127_426764_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000004076 222.0
HFD2_k127_429117_0 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000218 219.0
HFD2_k127_429117_1 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0002177 44.0
HFD2_k127_4294631_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 375.0
HFD2_k127_4294631_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000006287 225.0
HFD2_k127_4294631_2 Response regulator containing a CheY-like receiver domain and a GGDEF domain K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.00000000000000000000000000000000000000000000000000002507 202.0
HFD2_k127_4294631_3 Ribosomal protein L33 K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000009884 83.0
HFD2_k127_4323235_0 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 531.0
HFD2_k127_4323235_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 340.0
HFD2_k127_4323235_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000007611 164.0
HFD2_k127_4323235_3 Acetolactate synthase small subunit K01653 - 2.2.1.6 0.00000000000000000000002164 100.0
HFD2_k127_4337766_0 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 340.0
HFD2_k127_4337766_1 AraC-binding-like domain - - - 0.00000000000000000000000000000000000000000000000000000001838 213.0
HFD2_k127_4337766_2 PFAM Glutathione S-transferase domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000002805 203.0
HFD2_k127_4337766_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000002478 153.0
HFD2_k127_4374813_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 458.0
HFD2_k127_4374813_1 Branched-chain amino acid transport K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 436.0
HFD2_k127_4374813_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 285.0
HFD2_k127_4374813_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000003445 213.0
HFD2_k127_4374813_4 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000003676 87.0
HFD2_k127_4375187_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.843e-263 822.0
HFD2_k127_4375187_1 COG1180 Pyruvate-formate lyase-activating enzyme - - - 4.5e-228 742.0
HFD2_k127_4375187_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K09740 - - 0.00000000000001662 85.0
HFD2_k127_4395716_0 GTP-binding protein TypA K06207 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 315.0
HFD2_k127_4395716_1 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000221 202.0
HFD2_k127_4395716_2 Carboxylesterase family - - - 0.0000000000000000007753 93.0
HFD2_k127_4404286_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 477.0
HFD2_k127_4404286_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000006078 145.0
HFD2_k127_4404286_2 - - - - 0.0000000003193 64.0
HFD2_k127_4411099_0 Cell division protein FtsI penicillin-binding protein 2 K03587 - 3.4.16.4 0.000253 54.0
HFD2_k127_441147_0 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 481.0
HFD2_k127_441147_1 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002901 279.0
HFD2_k127_441147_2 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000008154 162.0
HFD2_k127_4417763_0 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - 6.404e-231 723.0
HFD2_k127_4417763_1 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 423.0
HFD2_k127_4417763_2 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 398.0
HFD2_k127_4417763_3 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000001019 246.0
HFD2_k127_4417763_4 binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000006246 227.0
HFD2_k127_4417763_5 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000112 177.0
HFD2_k127_4432852_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008266 457.0
HFD2_k127_4432852_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000002584 128.0
HFD2_k127_4432852_2 LysE type translocator - - - 0.00000000000000000000005509 100.0
HFD2_k127_4451825_0 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 9.346e-242 762.0
HFD2_k127_4451825_1 PFAM amine oxidase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000621 614.0
HFD2_k127_4451825_10 Protein of unknown function (DUF3108) - - - 0.0000000000000000002255 98.0
HFD2_k127_4451825_2 Taurine catabolism dioxygenase TauD, TfdA family K03119,K22303 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 391.0
HFD2_k127_4451825_3 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 333.0
HFD2_k127_4451825_4 4Fe-4S dicluster domain K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001546 251.0
HFD2_k127_4451825_5 Wd40 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000006209 217.0
HFD2_k127_4451825_6 DinB family - - - 0.000000000000000000000000000000000000000000000000000003288 201.0
HFD2_k127_4451825_7 COG0346 Lactoylglutathione lyase and related lyases - - - 0.000000000000000000000000000000000000000000000000001774 185.0
HFD2_k127_4451825_8 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000003265 142.0
HFD2_k127_4451825_9 cytochrome K08738 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944 - 0.00000000000000000000000001371 116.0
HFD2_k127_4451865_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007152 422.0
HFD2_k127_4451865_1 diguanylate cyclase - - - 0.0006705 49.0
HFD2_k127_4453639_0 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 367.0
HFD2_k127_4453639_1 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 295.0
HFD2_k127_4453639_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002164 279.0
HFD2_k127_4453639_3 glucose sorbosone K00117,K21430 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000001264 246.0
HFD2_k127_4453639_4 MarR family - - - 0.0000000000000000000000000000000000000004823 155.0
HFD2_k127_4453639_5 Rhodanese Homology Domain - - - 0.0000000000000000000000002991 118.0
HFD2_k127_4453639_6 N-terminal half of MaoC dehydratase - - - 0.00000000000000000003646 93.0
HFD2_k127_4466050_0 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 548.0
HFD2_k127_4466050_1 Bacterial membrane protein, YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 554.0
HFD2_k127_4466050_2 Belongs to the arginase family K01476,K18459 - 3.5.3.1,3.5.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 492.0
HFD2_k127_4466050_3 Putative Na+/H+ antiporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 498.0
HFD2_k127_4466050_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 385.0
HFD2_k127_4466050_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001778 261.0
HFD2_k127_4466050_6 Bacterial regulatory proteins, luxR family - - - 0.00000000000000000000000000000000000000000000000002829 185.0
HFD2_k127_4466050_7 Putative ATP-dependent DNA helicase recG C-terminal K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000001193 180.0
HFD2_k127_4466050_8 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000002118 67.0
HFD2_k127_4484903_0 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 462.0
HFD2_k127_4484903_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 371.0
HFD2_k127_4484903_2 Domain of unknown function (DUF1932) K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001578 293.0
HFD2_k127_4484903_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001006 276.0
HFD2_k127_4484903_4 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009016 272.0
HFD2_k127_4484903_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000001147 179.0
HFD2_k127_4484903_6 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.0000000000000000001716 96.0
HFD2_k127_4484903_7 Aldolase/RraA K10218 - 4.1.3.17 0.0000000255 57.0
HFD2_k127_4495527_0 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 308.0
HFD2_k127_4495527_1 Carboxylesterase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005828 273.0
HFD2_k127_4495527_2 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000003736 239.0
HFD2_k127_4495527_3 OmpA family K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000368 237.0
HFD2_k127_4496383_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 558.0
HFD2_k127_4496383_1 PFAM NMT1 THI5 like domain protein K02051 - - 0.000002343 51.0
HFD2_k127_4497516_0 ABC1 family - - - 3.388e-196 624.0
HFD2_k127_4497516_1 oligoendopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007208 259.0
HFD2_k127_4497516_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001444 254.0
HFD2_k127_4497516_3 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000003059 226.0
HFD2_k127_4497516_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000173 95.0
HFD2_k127_4524192_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 398.0
HFD2_k127_4524192_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 364.0
HFD2_k127_4524192_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 347.0
HFD2_k127_4524192_3 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 331.0
HFD2_k127_4524192_4 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 305.0
HFD2_k127_4524192_5 hydrolase (HAD superfamily) K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000001364 265.0
HFD2_k127_4524192_6 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000007256 190.0
HFD2_k127_4547252_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1035.0
HFD2_k127_4547252_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000009607 244.0
HFD2_k127_4557897_0 N-terminal domain of oxidoreductase K00001,K07119 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 363.0
HFD2_k127_4557897_1 Protein of unknown function (DUF3445) K22342 - 1.14.13.238 0.000000000000000000000000000000000000000000000000000000002752 212.0
HFD2_k127_4557897_2 Transglutaminase-like superfamily - - - 0.0000000000002908 72.0
HFD2_k127_4558_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 8.337e-291 904.0
HFD2_k127_4558_1 Involved in the TonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 549.0
HFD2_k127_4558_10 COG0811 Biopolymer transport proteins K03562 - - 0.0000000000000000000000000000000000000000000000000000000000007435 213.0
HFD2_k127_4558_11 Biopolymer transport protein K03559,K03560 - - 0.00000000000000000000000000000000000000000001627 168.0
HFD2_k127_4558_12 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000001083 142.0
HFD2_k127_4558_13 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000002351 143.0
HFD2_k127_4558_14 TIGRFAM protein TolA - - - 0.0000000000000000000009899 109.0
HFD2_k127_4558_15 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.0000000000000000004999 99.0
HFD2_k127_4558_2 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 528.0
HFD2_k127_4558_3 Glutathione S-Transferase K07393 - 1.8.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 387.0
HFD2_k127_4558_4 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 376.0
HFD2_k127_4558_5 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 349.0
HFD2_k127_4558_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 336.0
HFD2_k127_4558_7 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 299.0
HFD2_k127_4558_8 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001199 256.0
HFD2_k127_4558_9 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000001543 232.0
HFD2_k127_4580836_0 S53 subtilisin kexin sedolisin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 452.0
HFD2_k127_4580836_1 May be involved in the transport of PQQ or its precursor to the periplasm - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 310.0
HFD2_k127_4580836_2 Protein of unknown function (DUF2817) - - - 0.0000000000000000000000000000000000000000000000000000000000000000006245 239.0
HFD2_k127_4581230_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 364.0
HFD2_k127_4581230_1 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 322.0
HFD2_k127_4581230_2 Protein kinase domain - - - 0.0000000000000000000000000000000000000000129 171.0
HFD2_k127_4581230_3 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.00000000000000000000000000000000001363 138.0
HFD2_k127_4581406_0 Adenylate cyclase - - - 2.28e-248 781.0
HFD2_k127_4581406_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 3.976e-226 712.0
HFD2_k127_4581406_2 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 469.0
HFD2_k127_4581406_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004025 289.0
HFD2_k127_4581406_4 Belongs to the DnaA family - - - 0.00000000000000000000000000000000000000000000000000000000001888 223.0
HFD2_k127_4581406_5 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.000000000000000000000000000000000000000000000000003926 198.0
HFD2_k127_4581406_6 Phosphoglycerate mutase family K08296 - - 0.0000000000000000000000000000000000000000007371 163.0
HFD2_k127_4581406_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000002513 168.0
HFD2_k127_4592833_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 529.0
HFD2_k127_4592833_1 COG1520 FOG WD40-like repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 428.0
HFD2_k127_4592833_2 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000007867 139.0
HFD2_k127_4592833_3 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000103 138.0
HFD2_k127_4592833_4 KR domain - - - 0.000000002705 58.0
HFD2_k127_4592833_5 - - - - 0.00002329 52.0
HFD2_k127_4598190_0 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000004394 199.0
HFD2_k127_4598190_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000004232 197.0
HFD2_k127_4598190_2 FHA domain - - - 0.0000000000000000000000000000001196 133.0
HFD2_k127_461599_0 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 1.494e-206 676.0
HFD2_k127_461599_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 532.0
HFD2_k127_461599_2 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 301.0
HFD2_k127_461599_3 Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA K00219,K09461 - 1.14.13.40,1.3.1.34 0.000000000002845 80.0
HFD2_k127_4632107_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 4.482e-298 930.0
HFD2_k127_4632107_1 PFAM AMP-dependent synthetase and ligase K01895,K08295 - 6.2.1.1,6.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 381.0
HFD2_k127_4632107_2 Ketopantoate reductase PanE/ApbA C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 303.0
HFD2_k127_4632107_3 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000001251 169.0
HFD2_k127_4632107_4 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000002535 151.0
HFD2_k127_4650799_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1027.0
HFD2_k127_4650799_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 337.0
HFD2_k127_4650799_2 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000008754 170.0
HFD2_k127_4650799_3 Belongs to the BolA IbaG family - - - 0.00000000000000000000000000000000002392 135.0
HFD2_k127_4650799_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000001645 123.0
HFD2_k127_4650799_5 Rhomboid family - - - 0.0000000000000000000000000003107 124.0
HFD2_k127_4650799_6 Protein of unknown function (DUF2927) - - - 0.000000000000000000000003323 111.0
HFD2_k127_4650799_7 - - - - 0.000000000000006783 81.0
HFD2_k127_4666977_0 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002898 258.0
HFD2_k127_4666977_1 Major Facilitator Superfamily - - - 0.000000000000000008735 89.0
HFD2_k127_4667695_0 methyltransferase - - - 1.252e-195 624.0
HFD2_k127_4667695_1 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 483.0
HFD2_k127_4667695_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 350.0
HFD2_k127_4667695_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 354.0
HFD2_k127_4667695_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006798 263.0
HFD2_k127_4667695_5 thiamine-containing compound biosynthetic process K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000009654 253.0
HFD2_k127_4667695_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000008412 230.0
HFD2_k127_4667695_7 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000001806 171.0
HFD2_k127_4667695_8 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.0000000000000000000004338 108.0
HFD2_k127_4668444_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.091e-209 677.0
HFD2_k127_4668444_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 572.0
HFD2_k127_4668444_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 453.0
HFD2_k127_4668444_3 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000008114 189.0
HFD2_k127_4668444_4 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000005539 52.0
HFD2_k127_4668536_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000002244 211.0
HFD2_k127_4668536_1 hydratase' K02554 - 4.2.1.80 0.0000000000000000000000000000000000005081 143.0
HFD2_k127_4668536_2 Alpha beta hydrolase - - - 0.000000000000000000000000003654 122.0
HFD2_k127_4668536_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000142 108.0
HFD2_k127_4669458_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 552.0
HFD2_k127_4669458_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000003985 138.0
HFD2_k127_4674888_0 carboxylase K01969 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 501.0
HFD2_k127_4674888_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000004466 126.0
HFD2_k127_4677503_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296 - - 0.0 1375.0
HFD2_k127_4677503_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 425.0
HFD2_k127_4677503_2 - - - - 0.00000000000000000000000000000000003384 138.0
HFD2_k127_4677503_3 - - - - 0.0003338 52.0
HFD2_k127_4679726_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 616.0
HFD2_k127_4679726_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 449.0
HFD2_k127_4679726_10 - - - - 0.000004843 59.0
HFD2_k127_4679726_2 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 334.0
HFD2_k127_4679726_3 Cytochrome C1 family K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001278 259.0
HFD2_k127_4679726_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000002654 242.0
HFD2_k127_4679726_5 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000001089 194.0
HFD2_k127_4679726_6 Protein of unknown function (DUF3124) - - - 0.00000000000000000000000000000000000000000000000111 182.0
HFD2_k127_4679726_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000002426 170.0
HFD2_k127_4679726_8 ArsR family transcriptional regulator - - - 0.00000000000000000000000000002569 118.0
HFD2_k127_4679726_9 - - - - 0.00000002535 62.0
HFD2_k127_4680886_0 FOG Transposase and inactivated derivatives K07495 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 361.0
HFD2_k127_4680886_1 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.000000000000000000000000000000000000000000000000000007145 196.0
HFD2_k127_4680886_2 UreF - - - 0.00001976 48.0
HFD2_k127_4688739_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 586.0
HFD2_k127_4688739_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000009492 196.0
HFD2_k127_4700275_0 belongs to the aldehyde dehydrogenase family K00128,K00130 - 1.2.1.3,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009946 295.0
HFD2_k127_4700275_1 BON domain - - - 0.00000000000000000000000000000000000000000000000000000001251 209.0
HFD2_k127_4700275_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000002135 139.0
HFD2_k127_4700275_3 - - - - 0.0000000001291 68.0
HFD2_k127_4700275_4 Peptidase dimerisation domain - - - 0.000000004646 61.0
HFD2_k127_4702948_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 504.0
HFD2_k127_4702948_1 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 466.0
HFD2_k127_4702948_2 Protein of unknown function (DUF2848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001067 258.0
HFD2_k127_4702948_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000005975 213.0
HFD2_k127_4702948_4 GntR family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000003204 178.0
HFD2_k127_4702948_5 - - - - 0.000000000000002022 79.0
HFD2_k127_4702948_6 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000019 62.0
HFD2_k127_4714220_0 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 576.0
HFD2_k127_4714220_1 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 391.0
HFD2_k127_4714220_2 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 386.0
HFD2_k127_4714220_3 Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009494 256.0
HFD2_k127_4714220_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000203 204.0
HFD2_k127_4714220_5 belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000003934 184.0
HFD2_k127_4714220_6 protein conserved in bacteria - - - 0.000000000000000000000000000000000000004409 154.0
HFD2_k127_4727937_0 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000118 282.0
HFD2_k127_4727937_1 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000009479 108.0
HFD2_k127_4727937_2 transcriptional regulator - - - 0.00000000000000003537 89.0
HFD2_k127_4727937_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0003061 43.0
HFD2_k127_4737656_0 Sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008683 490.0
HFD2_k127_4737656_1 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 328.0
HFD2_k127_4737656_2 Ureidoglycolate lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 288.0
HFD2_k127_4737656_3 Carboxylesterase family - - - 0.000000000000000000000000000000000000000000000000000006699 195.0
HFD2_k127_4739312_0 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 390.0
HFD2_k127_4739312_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 349.0
HFD2_k127_4739312_2 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003683 247.0
HFD2_k127_4739312_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000001459 91.0
HFD2_k127_4739312_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000006455 67.0
HFD2_k127_4743781_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 536.0
HFD2_k127_4743781_1 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 480.0
HFD2_k127_4743781_2 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 306.0
HFD2_k127_4743781_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000005104 189.0
HFD2_k127_4743781_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000001109 158.0
HFD2_k127_4743781_5 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000003199 118.0
HFD2_k127_4743781_6 COG0591 Na proline symporter - - - 0.00000000000005248 78.0
HFD2_k127_4756426_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 599.0
HFD2_k127_4756426_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 375.0
HFD2_k127_4756426_10 EamA-like transporter family - - - 0.000000000000000000003351 108.0
HFD2_k127_4756426_11 Domain of unknown function (DUF1127) - - - 0.0000001698 57.0
HFD2_k127_4756426_2 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 334.0
HFD2_k127_4756426_3 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 324.0
HFD2_k127_4756426_4 isomerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 316.0
HFD2_k127_4756426_5 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 301.0
HFD2_k127_4756426_6 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000001522 258.0
HFD2_k127_4756426_7 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002027 268.0
HFD2_k127_4756426_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000002083 162.0
HFD2_k127_4756426_9 SnoaL-like domain - - - 0.00000000000000000000000001124 119.0
HFD2_k127_4794152_0 Amino acid amide ABC transporter substrate-binding protein, HAAT family K01999 - - 0.000000000000000000000000000000000000000000001169 185.0
HFD2_k127_4794152_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000001271 89.0
HFD2_k127_4794152_2 - K15754 - - 0.00000006748 59.0
HFD2_k127_4797393_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 581.0
HFD2_k127_4797393_1 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 378.0
HFD2_k127_4797393_2 COG1840 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 362.0
HFD2_k127_4797393_3 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000001871 209.0
HFD2_k127_4797393_4 MBOAT, membrane-bound O-acyltransferase family - - - 0.000000000003551 70.0
HFD2_k127_4797393_5 PFAM Transglycosylase-associated protein - - - 0.00001808 52.0
HFD2_k127_4801366_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 426.0
HFD2_k127_4801366_1 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001765 276.0
HFD2_k127_4801366_2 DNA polymerase X family K02347 - - 0.00000000000000000000001756 116.0
HFD2_k127_4805015_0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 413.0
HFD2_k127_4805015_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 385.0
HFD2_k127_4805015_2 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000000000000000004708 166.0
HFD2_k127_4805015_3 Rubrerythrin - - - 0.000000000000000000000000000000002914 134.0
HFD2_k127_4809009_0 glyoxalase K08234 - - 0.00000000000000000000000000000000000000000000000000000000001271 223.0
HFD2_k127_4809009_1 FCD K11475 - - 0.000000000000000000000000000000000000000000000000007371 190.0
HFD2_k127_4809009_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000001805 111.0
HFD2_k127_4810875_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 4.396e-249 784.0
HFD2_k127_4810875_1 COG1145 Ferredoxin - - - 0.0000000000000000000000000000000000000000000000000005889 199.0
HFD2_k127_4810875_2 AAA domain (dynein-related subfamily) - - - 0.00000000000000000005867 89.0
HFD2_k127_481451_0 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 314.0
HFD2_k127_481451_1 Nucleotidyl transferase K00966,K00992 - 2.7.7.13,2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000953 293.0
HFD2_k127_481451_2 ATPase or kinase K06925,K07102 - 2.7.1.221 0.0000000000000000000000000000000000001795 146.0
HFD2_k127_481451_3 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00000000000000004041 87.0
HFD2_k127_4819909_0 Bacterial extracellular solute-binding protein, family 7 - - - 4.249e-207 652.0
HFD2_k127_4819909_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008676 429.0
HFD2_k127_4819909_2 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 285.0
HFD2_k127_4819909_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000611 224.0
HFD2_k127_4819909_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000006382 83.0
HFD2_k127_4819909_5 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000004589 64.0
HFD2_k127_4819909_6 Hypoxia induced protein conserved region - - - 0.00003284 48.0
HFD2_k127_4821260_0 Belongs to the beta-ketoacyl-ACP synthases family K00647 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 544.0
HFD2_k127_4821260_1 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000009203 232.0
HFD2_k127_4821260_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000001525 184.0
HFD2_k127_4821260_3 FabA-like domain K01716 - 4.2.1.59,5.3.3.14 0.00000000008138 63.0
HFD2_k127_4824915_0 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 314.0
HFD2_k127_4824915_1 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000003538 66.0
HFD2_k127_4824915_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0003641 43.0
HFD2_k127_4828876_0 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 454.0
HFD2_k127_4828876_1 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000001427 148.0
HFD2_k127_4828876_2 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000029 138.0
HFD2_k127_4828876_3 - - - - 0.000000007226 61.0
HFD2_k127_4858630_0 cell division K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 314.0
HFD2_k127_4858630_1 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000229 216.0
HFD2_k127_4858630_2 Cell division protein K09811 - - 0.0000000000000000000000000000000000000000000000000000000001391 222.0
HFD2_k127_4858630_3 DUF218 domain - - - 0.00000000000000000000000000000000004459 143.0
HFD2_k127_4858630_4 Protein of unknown function (DUF3426) - - - 0.00000000000000000000000004427 118.0
HFD2_k127_4858630_5 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000000000394 66.0
HFD2_k127_4876448_0 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 482.0
HFD2_k127_4876448_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 384.0
HFD2_k127_4876448_2 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000000000004693 236.0
HFD2_k127_4876448_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.000000000000000000000000000000000000000000000000000000003653 207.0
HFD2_k127_4876448_4 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000001127 181.0
HFD2_k127_4876448_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000000000007658 112.0
HFD2_k127_4876448_6 Cytotoxic translational repressor of toxin-antitoxin stability system - - - 0.0000197 50.0
HFD2_k127_4881810_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 445.0
HFD2_k127_4881810_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 292.0
HFD2_k127_4881810_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000006785 141.0
HFD2_k127_4886297_0 Tyrosine-protein kinase, subgroup, catalytic domain K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 407.0
HFD2_k127_4886297_1 Response regulator receiver - - - 0.0000000000000000000000000000000502 130.0
HFD2_k127_4889521_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 328.0
HFD2_k127_4889521_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005682 288.0
HFD2_k127_4889521_2 PIN domain - - - 0.00000000000000000000000000000000001312 139.0
HFD2_k127_4889521_3 Rv0623-like transcription factor K19687 - - 0.000000000000000000003135 95.0
HFD2_k127_4892732_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 7.646e-200 632.0
HFD2_k127_4892732_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009259 456.0
HFD2_k127_4892732_2 COG1253 Hemolysins and related proteins containing CBS domains K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 308.0
HFD2_k127_4892732_3 COG1702 Phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000004804 222.0
HFD2_k127_4892732_4 transcriptional - - - 0.000000000000000000000000000000000000000000000006423 176.0
HFD2_k127_4892732_5 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000002929 144.0
HFD2_k127_4894808_0 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004626 283.0
HFD2_k127_4894808_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000137 261.0
HFD2_k127_4894808_2 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000008491 191.0
HFD2_k127_4894808_3 Protein of unknown function (DUF1428) K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000003821 192.0
HFD2_k127_4894808_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000001378 73.0
HFD2_k127_4938739_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 299.0
HFD2_k127_4938739_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008883 260.0
HFD2_k127_4938739_2 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000003945 147.0
HFD2_k127_4938739_3 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000001884 119.0
HFD2_k127_4952299_0 Periplasmic glucan biosynthesis protein, MdoG K03670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 596.0
HFD2_k127_4952299_1 Cupin superfamily protein - - - 0.000000000000000000000000000000000000000000000000000000000000233 224.0
HFD2_k127_4984875_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001188 283.0
HFD2_k127_4984875_1 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000003398 146.0
HFD2_k127_4984875_2 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000002487 133.0
HFD2_k127_4984875_3 EamA-like transporter family - - - 0.000000000000000000000000000007551 122.0
HFD2_k127_4984875_4 Copper resistance protein D K07245 - - 0.00000000000000000000000000008028 127.0
HFD2_k127_4984875_5 - - - - 0.0000000000000000000000000006298 123.0
HFD2_k127_4984875_6 CopC domain K07156 - - 0.000000000000000000000000893 113.0
HFD2_k127_4992605_0 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 425.0
HFD2_k127_4992605_1 COG0412 Dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 366.0
HFD2_k127_4992605_2 PFAM Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 358.0
HFD2_k127_4992605_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003928 279.0
HFD2_k127_4992605_4 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000007551 123.0
HFD2_k127_4992605_5 Esterase-like activity of phytase - - - 0.000000000000000000001407 107.0
HFD2_k127_4992605_6 Esterase-like activity of phytase - - - 0.000000002913 62.0
HFD2_k127_4992605_7 Esterase-like activity of phytase - - - 0.0000008475 53.0
HFD2_k127_5001813_0 Asparagine synthase K01953 - 6.3.5.4 1.27e-197 631.0
HFD2_k127_5001813_1 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 314.0
HFD2_k127_5011559_0 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 490.0
HFD2_k127_5011559_1 Pyruvate ferredoxin/flavodoxin oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 367.0
HFD2_k127_5011559_2 WD40 repeats - - - 0.0000000003314 71.0
HFD2_k127_5011559_3 PaaX-like protein K02616 - - 0.00003657 46.0
HFD2_k127_5024498_0 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007276 620.0
HFD2_k127_5024498_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 601.0
HFD2_k127_5024498_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 492.0
HFD2_k127_5046101_0 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 358.0
HFD2_k127_5046101_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 343.0
HFD2_k127_5046101_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000881 224.0
HFD2_k127_5046101_3 anion transmembrane transporter activity K02049,K02050 - - 0.00000000000000000000000000000000000000000000000000000000004167 226.0
HFD2_k127_5046101_4 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 0.00000000000000000000000000000000000005149 144.0
HFD2_k127_5046101_5 Chorismate mutase type II K04782 - 4.2.99.21 0.000000000000000001305 90.0
HFD2_k127_505044_0 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000323 286.0
HFD2_k127_505044_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000006138 214.0
HFD2_k127_505044_2 Haem-degrading - - - 0.000000000000000000000000000000000000000000000000008189 184.0
HFD2_k127_5052074_0 Penicillin amidase K01434 - 3.5.1.11 8.567e-220 708.0
HFD2_k127_5052074_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 392.0
HFD2_k127_5052074_2 transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000001916 224.0
HFD2_k127_5052074_3 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000001965 150.0
HFD2_k127_5052074_4 phosphohistidine phosphatase, SixA - - - 0.000000000000000000000000000003494 130.0
HFD2_k127_5052074_5 - - - - 0.0000000000000000000000000498 112.0
HFD2_k127_5052074_6 Belongs to the GST superfamily K11209 - - 0.00000000002792 73.0
HFD2_k127_5052074_7 Peptidoglycan-binding domain 1 protein K07260 - 3.4.17.14 0.0006801 52.0
HFD2_k127_5056957_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 432.0
HFD2_k127_5056957_1 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 403.0
HFD2_k127_5056957_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000001681 194.0
HFD2_k127_5056957_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.0002332 50.0
HFD2_k127_5066291_0 Cytochrome c K17230 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 506.0
HFD2_k127_5066291_1 Cytochrome c K17230 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 383.0
HFD2_k127_5066291_2 Belongs to the 5'-nucleotidase family K17224 - - 0.00000000000000000000000481 102.0
HFD2_k127_5070496_0 COG0165 Argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 1.521e-200 636.0
HFD2_k127_5073272_0 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 419.0
HFD2_k127_5073272_1 Mandelate Racemase Muconate Lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 401.0
HFD2_k127_5081085_0 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 417.0
HFD2_k127_5081085_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
HFD2_k127_5081085_2 transcriptional regulator K02624,K13641 - - 0.00000000000000000000000000000000000000000000000000000000000000005 232.0
HFD2_k127_5086833_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596 - 4.1.1.64 1.85e-213 674.0
HFD2_k127_5086833_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002964 253.0
HFD2_k127_5086833_2 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000008316 129.0
HFD2_k127_5086833_3 Domain of unknown function (DUF4189) - - - 0.00006222 50.0
HFD2_k127_5092441_0 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000001047 205.0
HFD2_k127_5092441_1 2Fe-2S -binding domain protein K03518,K07302,K19819 - 1.2.5.3,1.3.99.16,1.5.99.4 0.000000000000000000000000000000000000000000000001835 177.0
HFD2_k127_5092441_2 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000001096 136.0
HFD2_k127_5092441_3 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.00000000000000000751 92.0
HFD2_k127_5101004_0 Belongs to the peptidase S1C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 439.0
HFD2_k127_5101004_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 395.0
HFD2_k127_5127679_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000008108 260.0
HFD2_k127_5127679_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000002288 205.0
HFD2_k127_5127679_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000001187 167.0
HFD2_k127_5127679_3 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000001655 108.0
HFD2_k127_5129234_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000003382 166.0
HFD2_k127_5129234_1 Major facilitator Superfamily K05820,K08217 - - 0.000000000000000000000000101 118.0
HFD2_k127_5138756_0 Malonyl-CoA decarboxylase N-terminal domain K01578 - 4.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 511.0
HFD2_k127_5138756_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001026 244.0
HFD2_k127_5138756_2 PFAM thioesterase superfamily protein K07107 - - 0.000000000000000000000000000000000000000000000000000003819 195.0
HFD2_k127_5138756_3 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000002759 190.0
HFD2_k127_5162659_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00651 - 2.3.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 381.0
HFD2_k127_5162659_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005705 258.0
HFD2_k127_5168494_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 423.0
HFD2_k127_5168494_1 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000001495 200.0
HFD2_k127_5168494_2 SMART Extracellular solute-binding protein, family 3 K02030 - - 0.0000000000000000000000000000000000001234 160.0
HFD2_k127_5168494_3 Protein of unknown function (DUF2892) - - - 0.0000000000000003553 81.0
HFD2_k127_5168494_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000002933 83.0
HFD2_k127_5168494_5 ATPase with chaperone activity - - - 0.0000001354 54.0
HFD2_k127_5194372_0 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 312.0
HFD2_k127_5194372_1 3-5 exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 293.0
HFD2_k127_5194372_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000001354 156.0
HFD2_k127_521020_0 Belongs to the aldehyde dehydrogenase family K00130,K00151,K10217 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0008802,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85 5.839e-227 714.0
HFD2_k127_521020_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.00000000000000000000000000000000000000008668 155.0
HFD2_k127_5215141_0 nitrilase K01501,K01502 - 3.5.5.1,3.5.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 406.0
HFD2_k127_5215141_1 Rieske 2Fe-2S domain protein K14748 - - 0.00000000000000000000000000000000000000000000003612 172.0
HFD2_k127_5215141_2 Transcriptional regulator - - - 0.00000000000002347 80.0
HFD2_k127_5215141_3 AraC-binding-like domain - - - 0.00008969 51.0
HFD2_k127_5237271_0 aldo-keto reductase (NADP) activity K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 330.0
HFD2_k127_5237271_1 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006756 259.0
HFD2_k127_5237271_2 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000005528 202.0
HFD2_k127_5237271_3 SMART PDZ DHR GLGF domain protein - - - 0.0000000000000000000000000000000000002111 157.0
HFD2_k127_5237271_4 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000001001 133.0
HFD2_k127_5249825_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 456.0
HFD2_k127_5249825_1 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007105 356.0
HFD2_k127_5249825_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007631 285.0
HFD2_k127_5249825_3 Phenylacetate-CoA oxygenase K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000008231 221.0
HFD2_k127_5249825_4 chorismate mutase - - - 0.00002531 54.0
HFD2_k127_5249825_5 Belongs to the UPF0335 family - - - 0.00003331 46.0
HFD2_k127_5263733_0 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001086 274.0
HFD2_k127_5263733_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K11959 - - 0.00000000000000000000000115 105.0
HFD2_k127_5275272_0 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 522.0
HFD2_k127_5275272_1 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 375.0
HFD2_k127_5275272_2 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000000000000000009648 205.0
HFD2_k127_5275272_3 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000000000000000002813 205.0
HFD2_k127_5275272_5 - - - - 0.000000000192 67.0
HFD2_k127_5275272_6 - - - - 0.00008125 51.0
HFD2_k127_5276341_0 NADH-ubiquinone oxidoreductase chain 49kDa - - - 2.364e-229 720.0
HFD2_k127_5276341_1 Proton-conducting membrane transporter K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 388.0
HFD2_k127_5298341_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 443.0
HFD2_k127_5298341_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000004589 226.0
HFD2_k127_5298341_2 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000928 168.0
HFD2_k127_5298341_3 Protein of unknown function (DUF465) - - - 0.0000000000000000002533 89.0
HFD2_k127_5298341_4 PFAM conserved - - - 0.00002856 46.0
HFD2_k127_5337864_0 fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 367.0
HFD2_k127_5337864_1 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.0000000000000000000000000000000004785 136.0
HFD2_k127_5337864_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000008251 144.0
HFD2_k127_5337864_3 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid K00151 - 1.2.1.60 0.000000000000000000000003424 105.0
HFD2_k127_5349014_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 4.771e-270 839.0
HFD2_k127_5349014_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
HFD2_k127_5349014_2 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000001298 162.0
HFD2_k127_5349014_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000004908 95.0
HFD2_k127_5362370_0 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 297.0
HFD2_k127_5362370_1 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000004196 227.0
HFD2_k127_5362370_2 ABC transporter substrate binding protein K01989 - - 0.00000000000000004842 81.0
HFD2_k127_5364633_0 Tripartite tricarboxylate transporter family receptor K07795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 361.0
HFD2_k127_5364633_1 Tripartite tricarboxylate transporter TctB family - - - 0.000000000000000000000000000000000000000000000003554 178.0
HFD2_k127_5364633_2 Protein of unknown function (DUF1289) K06938 - - 0.0000000000006471 73.0
HFD2_k127_5364633_3 Protein of unknown function (DUF1289) K06938 - - 0.0000000001797 67.0
HFD2_k127_538383_0 Psort location Cytoplasmic, score 7.50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 504.0
HFD2_k127_538383_1 copper-resistance protein, CopA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 426.0
HFD2_k127_538383_2 - - - - 0.0000000000000000000000000000000000000000000000000001279 199.0
HFD2_k127_5384927_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.185e-226 715.0
HFD2_k127_5384927_1 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 480.0
HFD2_k127_5384927_2 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 457.0
HFD2_k127_5384927_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 458.0
HFD2_k127_5384927_4 N-terminal TM domain of oligopeptide transport permease C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005634 402.0
HFD2_k127_5384927_5 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 396.0
HFD2_k127_5384927_6 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000003293 186.0
HFD2_k127_5384927_7 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000001245 176.0
HFD2_k127_5384927_8 Domain of unknown function (DUF4167) - - - 0.00000000000000000005082 100.0
HFD2_k127_5392337_0 ABC-2 family transporter protein K01990,K13926 - - 1.804e-208 657.0
HFD2_k127_5392337_1 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 532.0
HFD2_k127_5392337_2 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000002134 228.0
HFD2_k127_5392337_3 OsmC-like protein K06889,K07397 - - 0.000000000000000000000000000000000000000000000008217 177.0
HFD2_k127_5392337_4 transcriptional regulator - - - 0.00000000000000000000000000449 120.0
HFD2_k127_539352_0 PD-(D/E)XK nuclease superfamily K16898 - 3.6.4.12 4.107e-263 849.0
HFD2_k127_539352_1 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 4.238e-226 729.0
HFD2_k127_539352_2 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 420.0
HFD2_k127_539352_3 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000000000843 185.0
HFD2_k127_539352_4 PFAM Excinuclease ABC C subunit domain protein K07461 - - 0.000000000002147 69.0
HFD2_k127_5393994_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007622 248.0
HFD2_k127_5393994_1 Belongs to the bacterial solute-binding protein 3 family K09969 - - 0.0000000000000000000000000000000000000000000000000000000000000001175 229.0
HFD2_k127_5393994_2 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000000000005676 183.0
HFD2_k127_5393994_3 oxidoreductase activity - - - 0.00000000000006255 74.0
HFD2_k127_5393994_4 Trm112p-like protein K09791 - - 0.00000000002146 64.0
HFD2_k127_5398319_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008663 446.0
HFD2_k127_5398319_1 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 394.0
HFD2_k127_5398319_2 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 387.0
HFD2_k127_5398319_3 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000001748 238.0
HFD2_k127_5398319_4 Cytochrome c - - - 0.000000001209 63.0
HFD2_k127_5398781_0 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001945 276.0
HFD2_k127_5398781_1 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007391 277.0
HFD2_k127_5398781_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000001802 84.0
HFD2_k127_5398781_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000003255 69.0
HFD2_k127_5402423_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000006199 223.0
HFD2_k127_5402423_1 ADP-glyceromanno-heptose 6-epimerase activity K00091,K22320 - 1.1.1.219,1.1.1.412 0.000000000000000000000000002647 122.0
HFD2_k127_5402423_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000001741 93.0
HFD2_k127_5406245_0 Adenylate cyclase - - - 6.59e-275 852.0
HFD2_k127_5406245_1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 2.193e-264 825.0
HFD2_k127_5406245_2 Aminotransferase K14261 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 599.0
HFD2_k127_5406245_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 539.0
HFD2_k127_5406245_4 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446,K11532 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 490.0
HFD2_k127_5406245_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 313.0
HFD2_k127_5406245_6 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002168 276.0
HFD2_k127_5406245_7 Phospholipid N-methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.00000000000000000000000000000000000000000000000000000016 201.0
HFD2_k127_5406245_8 single-stranded-DNA-specific exonuclease recJ K07462 - - 0.0000000000000000000000000000000000000000000001371 175.0
HFD2_k127_5409759_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 590.0
HFD2_k127_5409759_1 ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000002165 231.0
HFD2_k127_5409759_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000335 67.0
HFD2_k127_542731_0 PFAM Uncharacterised protein family UPF0027 K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 494.0
HFD2_k127_542731_1 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 375.0
HFD2_k127_5447978_0 III protein, CoA-transferase family K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 507.0
HFD2_k127_5447978_1 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000000000000000000597 219.0
HFD2_k127_5447978_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000218 190.0
HFD2_k127_5447978_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000004207 130.0
HFD2_k127_5451531_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005798 269.0
HFD2_k127_5451531_1 Domain of unknown function (DUF4439) - - - 0.0000000000000000000000000000000000000000000000000000000003951 215.0
HFD2_k127_5451531_2 COG1108 ABC-type Mn2 Zn2 transport systems, permease components K09816 - - 0.0000000000000000000000000000000000000000000000003249 181.0
HFD2_k127_5451531_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000006196 180.0
HFD2_k127_5451531_4 Cytochrome c K08738 - - 0.000000000000000000000000000000000000000001635 165.0
HFD2_k127_5451531_5 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000006487 97.0
HFD2_k127_5455850_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 484.0
HFD2_k127_5455850_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000006092 165.0
HFD2_k127_5455850_2 lactoylglutathione lyase activity - - - 0.0000000000004818 70.0
HFD2_k127_5458403_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 357.0
HFD2_k127_5458403_1 PFAM Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006036 276.0
HFD2_k127_5458403_2 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000005916 262.0
HFD2_k127_5459898_0 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 1.268e-196 635.0
HFD2_k127_5459898_1 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000002467 258.0
HFD2_k127_5459898_2 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000000000006035 218.0
HFD2_k127_5459898_3 PFAM DoxX family protein K15977 - - 0.000000000006881 74.0
HFD2_k127_5466680_0 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 361.0
HFD2_k127_5466680_1 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009262 273.0
HFD2_k127_5466680_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002233 268.0
HFD2_k127_5466680_3 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.0000000000000000000000000000000000000000000000000000000000000000005871 231.0
HFD2_k127_5466680_4 Isochorismatase family - - - 0.00000000000000000000003241 102.0
HFD2_k127_5472352_0 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 492.0
HFD2_k127_5472352_1 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005815 365.0
HFD2_k127_5485393_0 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 574.0
HFD2_k127_5485393_1 Alcohol dehydrogenase GroES-like domain K00001,K00008 - 1.1.1.1,1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 385.0
HFD2_k127_5485393_2 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 334.0
HFD2_k127_5485393_3 PFAM ABC transporter related K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 343.0
HFD2_k127_5485393_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003203 286.0
HFD2_k127_5485393_5 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002599 289.0
HFD2_k127_5485393_6 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000353 194.0
HFD2_k127_5485393_7 lactoylglutathione lyase activity K08234 - - 0.000000000000000000000000000000000002487 148.0
HFD2_k127_5485393_8 PFAM ABC transporter K01996 - - 0.00000000000000000000009946 113.0
HFD2_k127_5485393_9 Transport permease protein K01992 - - 0.000000001425 68.0
HFD2_k127_5504798_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.747e-242 753.0
HFD2_k127_5504798_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 346.0
HFD2_k127_5504798_2 Domain of unknown function (4846) - - - 0.0000000000000000000000000000000000000000000000000000000000000001515 228.0
HFD2_k127_5504798_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000001555 186.0
HFD2_k127_5504798_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000002207 183.0
HFD2_k127_5504798_5 RDD family - - - 0.0000002755 59.0
HFD2_k127_5504798_6 RDD family - - - 0.000009877 54.0
HFD2_k127_5524167_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - 1.257e-294 920.0
HFD2_k127_5524167_1 Pyruvate ferredoxin/flavodoxin oxidoreductase - - - 0.0000000000000000000000000000000000000000000000001172 179.0
HFD2_k127_5524167_2 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000398 178.0
HFD2_k127_5530701_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 1.101e-233 733.0
HFD2_k127_5530701_1 Polysaccharide biosynthesis protein K13013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 501.0
HFD2_k127_5530701_2 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 319.0
HFD2_k127_5530701_3 mechanosensitive ion channel activity K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.000000000000000000000000000000000000000000003253 177.0
HFD2_k127_5530701_4 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000001256 99.0
HFD2_k127_5534069_0 poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 394.0
HFD2_k127_5534069_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
HFD2_k127_5534069_2 Protein of unknown function (DUF1285) K09986 - - 0.000000000000000000000000000000000000000000000000000000000006236 220.0
HFD2_k127_5534069_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000007956 195.0
HFD2_k127_5534069_4 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000001191 177.0
HFD2_k127_5534069_5 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000001335 161.0
HFD2_k127_5534069_6 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.0000000000000000000001485 112.0
HFD2_k127_5534069_7 PFAM Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000001587 86.0
HFD2_k127_5560871_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 368.0
HFD2_k127_5560871_1 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 304.0
HFD2_k127_5560871_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 316.0
HFD2_k127_5560871_3 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002663 282.0
HFD2_k127_5560871_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000001135 233.0
HFD2_k127_5560871_5 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000002652 243.0
HFD2_k127_5560871_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000001615 135.0
HFD2_k127_5578994_0 alpha beta - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001236 256.0
HFD2_k127_5578994_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000002908 196.0
HFD2_k127_5613038_0 transposase IS4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 454.0
HFD2_k127_5613038_1 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002698 265.0
HFD2_k127_5613038_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000005419 173.0
HFD2_k127_5613038_3 nuclease - - - 0.00000000000000000000000000000000007871 143.0
HFD2_k127_5613038_4 Helix-turn-helix domain - - - 0.000000003667 59.0
HFD2_k127_5613038_5 PAS domain - - - 0.00000051 59.0
HFD2_k127_5622804_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006546 442.0
HFD2_k127_5622804_1 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 409.0
HFD2_k127_5622804_2 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 289.0
HFD2_k127_5622804_3 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 291.0
HFD2_k127_5622804_4 Aldo/keto reductase family K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008217 287.0
HFD2_k127_5622804_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003835 257.0
HFD2_k127_5622804_6 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000007722 214.0
HFD2_k127_5645205_0 Glycosyl hydrolases family 15 - - - 7.514e-242 762.0
HFD2_k127_5645205_1 Cupin domain - - - 0.00000000000000000000000000000000000000000000004114 173.0
HFD2_k127_5645205_2 MarR family - - - 0.000000000000000000000000000001305 125.0
HFD2_k127_5645205_3 Tetratricopeptide repeat - - - 0.00000000000000001654 91.0
HFD2_k127_5645205_4 Tetratricopeptide repeat - - - 0.000000000006326 76.0
HFD2_k127_5684976_0 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 290.0
HFD2_k127_5684976_1 COG2267 Lysophospholipase - - - 0.00000000000000000000000000000000000000000000000000000000001281 213.0
HFD2_k127_5684976_2 SnoaL-like domain - - - 0.00000000000000000000000000002655 122.0
HFD2_k127_5684976_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000002279 78.0
HFD2_k127_5684976_4 Cytochrome c - - - 0.000000000006167 70.0
HFD2_k127_5684976_5 EF hand - - - 0.00000001251 64.0
HFD2_k127_5698443_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.089e-206 653.0
HFD2_k127_5698443_1 Domain of unknown function (DUF3390) K18929 - - 8.588e-200 636.0
HFD2_k127_5698443_10 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.0000000000000000000000000000000000000000009821 162.0
HFD2_k127_5698443_11 protein conserved in bacteria - - - 0.00000000000000000000000000004104 127.0
HFD2_k127_5698443_12 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000002515 76.0
HFD2_k127_5698443_2 (Fe-S) oxidoreductase K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 336.0
HFD2_k127_5698443_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003201 272.0
HFD2_k127_5698443_4 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000111 273.0
HFD2_k127_5698443_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000003577 255.0
HFD2_k127_5698443_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000003458 214.0
HFD2_k127_5698443_7 LUD domain K00782 - - 0.0000000000000000000000000000000000000000000000000000000003447 215.0
HFD2_k127_5698443_8 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000004435 191.0
HFD2_k127_5698443_9 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000004114 167.0
HFD2_k127_5702259_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 339.0
HFD2_k127_5702259_1 PFAM Response regulator receiver domain K15012 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003219 271.0
HFD2_k127_5702259_2 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000001338 233.0
HFD2_k127_5702259_3 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000001132 163.0
HFD2_k127_5702259_4 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.000000000000000000000000000000000000003248 159.0
HFD2_k127_5702259_5 Autotransporter beta-domain - - - 0.00002329 52.0
HFD2_k127_5715700_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 1.254e-263 821.0
HFD2_k127_5715700_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 557.0
HFD2_k127_5715700_2 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 539.0
HFD2_k127_5715700_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009854 274.0
HFD2_k127_5715700_4 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004624 249.0
HFD2_k127_5720787_0 KR domain K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 285.0
HFD2_k127_5720787_1 Bacterial protein of unknown function (DUF898) - - - 0.0000000000000000000000000000000000000000000000000000000005806 221.0
HFD2_k127_5720787_2 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000001386 166.0
HFD2_k127_5732250_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 512.0
HFD2_k127_5732250_1 Lipoprotein releasing system transmembrane protein LolC K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 477.0
HFD2_k127_5732250_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000001123 155.0
HFD2_k127_5732250_11 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000001443 134.0
HFD2_k127_5732250_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000001401 91.0
HFD2_k127_5732250_13 - - - - 0.00000000000009521 78.0
HFD2_k127_5732250_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 406.0
HFD2_k127_5732250_3 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 364.0
HFD2_k127_5732250_4 (ABC) transporter K05685,K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 306.0
HFD2_k127_5732250_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 299.0
HFD2_k127_5732250_6 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001366 272.0
HFD2_k127_5732250_7 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005257 245.0
HFD2_k127_5732250_8 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000002879 238.0
HFD2_k127_5732250_9 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000118 199.0
HFD2_k127_5745220_0 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000005212 269.0
HFD2_k127_5745220_1 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000005797 211.0
HFD2_k127_5745220_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000009652 206.0
HFD2_k127_5745220_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000002266 64.0
HFD2_k127_575224_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.022e-195 619.0
HFD2_k127_575224_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 436.0
HFD2_k127_575224_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000003035 162.0
HFD2_k127_575224_3 Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.00000000000000000006161 97.0
HFD2_k127_575224_4 septum formation initiator - - - 0.00000000000003661 76.0
HFD2_k127_5768193_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 306.0
HFD2_k127_5768193_1 Domain of unknown function (DUF4345) - - - 0.0000000000000000000000000000001213 128.0
HFD2_k127_5782160_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 291.0
HFD2_k127_5782160_1 FAD binding domain in molybdopterin dehydrogenase K03519 - 1.2.5.3 0.000000000000000000002793 99.0
HFD2_k127_5782160_2 Transcriptional regulator - - - 0.000000001039 66.0
HFD2_k127_5791903_0 (LPS) heptosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 314.0
HFD2_k127_5791903_1 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 302.0
HFD2_k127_5791903_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 306.0
HFD2_k127_5791903_3 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000003504 237.0
HFD2_k127_58103_0 Stimulus-sensing domain K14980 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 456.0
HFD2_k127_58103_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.00000000000000000000000000000000000000000000000000000000006792 205.0
HFD2_k127_5853946_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 467.0
HFD2_k127_5853946_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000601 172.0
HFD2_k127_5853946_2 Belongs to the SEDS family K03588 - - 0.0000000003412 61.0
HFD2_k127_5892818_0 COG0708 Exonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 368.0
HFD2_k127_5892818_1 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009208 307.0
HFD2_k127_5892818_2 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000001338 181.0
HFD2_k127_5893596_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000001988 177.0
HFD2_k127_5893596_1 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K00015,K03778 - 1.1.1.26,1.1.1.28 0.0006089 44.0
HFD2_k127_5896857_0 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1612.0
HFD2_k127_5896857_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000436 96.0
HFD2_k127_5908179_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 385.0
HFD2_k127_5908179_1 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 387.0
HFD2_k127_5908179_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 310.0
HFD2_k127_5912616_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 454.0
HFD2_k127_5912616_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000133 258.0
HFD2_k127_5912616_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000001776 164.0
HFD2_k127_5922760_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 9.103e-317 987.0
HFD2_k127_5922760_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 527.0
HFD2_k127_5922760_2 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 426.0
HFD2_k127_5922760_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000008269 223.0
HFD2_k127_5922760_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000004279 158.0
HFD2_k127_5922760_5 Paraquat-inducible protein A K03808 - - 0.000000000000000000000000003513 117.0
HFD2_k127_5922760_6 Endoribonuclease L-PSP - - - 0.000000000000000000000001652 109.0
HFD2_k127_5922760_7 - - - - 0.000000000000000000001826 98.0
HFD2_k127_5922760_8 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000004918 65.0
HFD2_k127_5922760_9 COG0859 ADP-heptose LPS heptosyltransferase - - - 0.0000000000824 64.0
HFD2_k127_5930088_0 ABC transporter, ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 409.0
HFD2_k127_5930088_1 OstA-like protein K09774 - - 0.000000000000000000000000000000000000000000000000000001058 204.0
HFD2_k127_5930088_2 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000000000000007422 153.0
HFD2_k127_5930088_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000003745 115.0
HFD2_k127_5930088_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000006455 67.0
HFD2_k127_5935023_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007228 551.0
HFD2_k127_5935023_1 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 482.0
HFD2_k127_5935023_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
HFD2_k127_5952652_0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 1.109e-288 899.0
HFD2_k127_5952652_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 349.0
HFD2_k127_5952652_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 309.0
HFD2_k127_5952652_3 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000001223 244.0
HFD2_k127_5952652_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000973 223.0
HFD2_k127_5952652_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000003535 113.0
HFD2_k127_5952652_6 Transcriptional - - - 0.0000003835 57.0
HFD2_k127_5969959_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.485e-304 966.0
HFD2_k127_5969959_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 312.0
HFD2_k127_5969959_2 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000003454 248.0
HFD2_k127_5969959_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008903 247.0
HFD2_k127_5969959_4 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000003992 205.0
HFD2_k127_5969959_5 GYD domain - - - 0.000000000000000000000000000002472 123.0
HFD2_k127_5992444_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 370.0
HFD2_k127_5992444_1 Belongs to the GST superfamily K11209 - - 0.00000000000000000000001325 103.0
HFD2_k127_5992444_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000002722 62.0
HFD2_k127_6006237_0 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 511.0
HFD2_k127_6006237_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 346.0
HFD2_k127_6006237_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000124 202.0
HFD2_k127_6006237_3 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000006197 171.0
HFD2_k127_6006237_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0000000000000000000000006057 105.0
HFD2_k127_6006237_5 Cyclin-dependent kinase inhibitor 3 (CDKN3) - - - 0.00000000000000000000005831 109.0
HFD2_k127_6006237_6 - - - - 0.000008939 58.0
HFD2_k127_6015453_0 dioxygenase K11159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 582.0
HFD2_k127_6015453_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 333.0
HFD2_k127_6015453_2 In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 K09020 - 3.5.1.110 0.00000000000000000000000000000000000000000000000000000005424 203.0
HFD2_k127_6015453_3 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000002226 122.0
HFD2_k127_6021053_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 579.0
HFD2_k127_6021053_1 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 484.0
HFD2_k127_6021053_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 424.0
HFD2_k127_6021053_3 COG1024 Enoyl-CoA hydratase carnithine racemase - - - 0.00000000000000000000000000000000000000000000000000000000006734 213.0
HFD2_k127_6021053_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000002189 121.0
HFD2_k127_6021053_5 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 0.00000000000000001564 84.0
HFD2_k127_6027031_0 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 575.0
HFD2_k127_6027031_1 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 293.0
HFD2_k127_6027031_2 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004583 245.0
HFD2_k127_6083149_0 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 395.0
HFD2_k127_6083149_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 346.0
HFD2_k127_6111711_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 318.0
HFD2_k127_6111711_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000002219 229.0
HFD2_k127_6111711_2 PhoQ Sensor - - - 0.00009243 46.0
HFD2_k127_6137976_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 432.0
HFD2_k127_6137976_1 Sodium/hydrogen exchanger family K03455 - - 0.000000000000000000000000000000000000000003053 160.0
HFD2_k127_6137976_2 Phosphotransferase enzyme family - - - 0.000000000000000000000002148 106.0
HFD2_k127_6138174_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 524.0
HFD2_k127_6138174_1 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000002618 220.0
HFD2_k127_6138174_2 Amino-transferase class IV K00824 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 0.0000000000000000000000000000000000000000000000000003322 189.0
HFD2_k127_6138174_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000004556 142.0
HFD2_k127_6138174_4 inositol monophosphatase - - - 0.00000000000002009 77.0
HFD2_k127_6147556_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 543.0
HFD2_k127_6147556_1 Winged helix-turn-helix DNA-binding - - - 0.00000000000000000000000000000000000000000000000000002277 195.0
HFD2_k127_6147556_2 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. - - - 0.0000000000000000000000000000000000000000000000000001131 190.0
HFD2_k127_6147556_3 PFAM NAD-dependent epimerase dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000001884 123.0
HFD2_k127_6147910_0 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000004639 188.0
HFD2_k127_6147910_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000001615 180.0
HFD2_k127_6147910_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051 - - 0.00000000000000000000000000000000000004751 149.0
HFD2_k127_6153116_0 AMP-binding enzyme C-terminal domain K04116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 465.0
HFD2_k127_6153116_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 366.0
HFD2_k127_6155676_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1072.0
HFD2_k127_6155676_1 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000002775 154.0
HFD2_k127_6171632_0 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 393.0
HFD2_k127_6171632_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 325.0
HFD2_k127_6171632_10 - - - - 0.00001887 55.0
HFD2_k127_6171632_2 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 316.0
HFD2_k127_6171632_3 Uracil-DNA glycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007179 285.0
HFD2_k127_6171632_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000002652 213.0
HFD2_k127_6171632_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000002239 180.0
HFD2_k127_6171632_6 Integral membrane protein (DUF2244) - - - 0.00000000000000000000000000000000000000001524 162.0
HFD2_k127_6171632_7 Fructosamine kinase - - - 0.00000000000000000000000000000000000000005269 157.0
HFD2_k127_6171632_8 Etoposide-induced protein 2.4 (EI24) - - - 0.00000000000000000000000000000000000004886 156.0
HFD2_k127_6171632_9 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000008039 61.0
HFD2_k127_6184708_0 TIGRFAM formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 473.0
HFD2_k127_6184708_1 PFAM Rieske 2Fe-2S - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 438.0
HFD2_k127_6184708_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000004201 150.0
HFD2_k127_6186536_0 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 501.0
HFD2_k127_6186536_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000001511 163.0
HFD2_k127_6196567_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01847 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 419.0
HFD2_k127_6196567_1 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002264 276.0
HFD2_k127_6196567_2 sugar phosphatases of the HAD superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004357 266.0
HFD2_k127_6196567_3 COQ9 K18587 - - 0.000000000000000000000000000000000000000000000000000000001873 208.0
HFD2_k127_6196567_4 - - - - 0.0000000000000000000000000000000000002684 144.0
HFD2_k127_6196567_5 Fic/DOC family K07341 - - 0.000000000000000000000000000000002672 132.0
HFD2_k127_6196567_6 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000000002585 114.0
HFD2_k127_6196567_7 COG2346, Truncated hemoglobins K06886 - - 0.00000000000000000000000004645 123.0
HFD2_k127_6196567_8 Addiction module antidote - - - 0.00000000000000005068 83.0
HFD2_k127_6208114_0 LppP/LprE lipoprotein - - - 0.0000000000000000000000000000008624 128.0
HFD2_k127_6208114_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000008653 100.0
HFD2_k127_6209846_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 512.0
HFD2_k127_6209846_1 Peptidase family S49 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 315.0
HFD2_k127_6209846_2 Methyltransferase small domain - - - 0.000000000000000000000000000000000000000000000000000000000000001383 224.0
HFD2_k127_6209846_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000009702 165.0
HFD2_k127_6228294_0 acyl-CoA dehydrogenase - - - 4.372e-198 623.0
HFD2_k127_6228294_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 418.0
HFD2_k127_6228294_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009093 310.0
HFD2_k127_6228294_3 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007692 275.0
HFD2_k127_6228294_4 Gaf domain K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 262.0
HFD2_k127_6228294_5 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006193 242.0
HFD2_k127_6228294_6 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000008429 173.0
HFD2_k127_6228294_7 antibiotic catabolic process - - - 0.000000000000000000000000007674 117.0
HFD2_k127_6228294_8 Sel1-like repeats. K07126 - - 0.00000000000000000000000004751 124.0
HFD2_k127_6232375_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 5.297e-200 627.0
HFD2_k127_6232375_1 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000002377 184.0
HFD2_k127_6232375_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000003359 57.0
HFD2_k127_6234855_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 3.582e-228 719.0
HFD2_k127_6243299_0 Formate dehydrogenase subunit alpha - - - 0.0 1015.0
HFD2_k127_6243299_1 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 622.0
HFD2_k127_6243299_2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 362.0
HFD2_k127_6243299_3 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 319.0
HFD2_k127_6243299_4 Protein of unknown function (DUF952) - - - 0.0000000000000000000000000000000000000000000003693 168.0
HFD2_k127_6267381_0 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007298 250.0
HFD2_k127_6267381_1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.0000000000000000000000000000000000000001042 153.0
HFD2_k127_6267381_2 Lipopolysaccharide assembly protein A domain - - - 0.000000000273 69.0
HFD2_k127_627394_0 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000419 346.0
HFD2_k127_627394_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 336.0
HFD2_k127_627394_2 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 325.0
HFD2_k127_627394_3 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 319.0
HFD2_k127_627394_4 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000001116 179.0
HFD2_k127_6275802_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 542.0
HFD2_k127_6275802_1 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 428.0
HFD2_k127_6275802_2 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 349.0
HFD2_k127_6275802_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH - - - 0.0000000000000000001774 90.0
HFD2_k127_6300455_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.838e-294 922.0
HFD2_k127_6300455_1 2-hydroxychromene-2-carboxylate isomerase - - - 0.00000000002926 64.0
HFD2_k127_6302152_0 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 371.0
HFD2_k127_6302152_1 Phosphorylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 357.0
HFD2_k127_6302152_2 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 348.0
HFD2_k127_6302152_3 SNARE associated Golgi protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 312.0
HFD2_k127_6302152_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000003446 225.0
HFD2_k127_6302152_5 DsrE/DsrF-like family K06039 - - 0.0000000000000000000000000000000000000000000000000000209 190.0
HFD2_k127_6302152_6 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000003297 153.0
HFD2_k127_6302152_7 Short C-terminal domain - - - 0.0000000000000000000006266 101.0
HFD2_k127_6311989_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.505e-203 641.0
HFD2_k127_6311989_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001371 274.0
HFD2_k127_6311989_2 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000004865 226.0
HFD2_k127_6311989_3 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000001013 179.0
HFD2_k127_6311989_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000009468 149.0
HFD2_k127_6311989_5 Ribosomal protein L30 K02907 - - 0.0000000000000004845 91.0
HFD2_k127_6311989_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - 0.00000000001265 64.0
HFD2_k127_6311989_7 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000531 63.0
HFD2_k127_6314214_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 7.733e-195 621.0
HFD2_k127_6314214_1 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000007667 145.0
HFD2_k127_6314214_2 membrane protein, required for colicin V production K03558 - - 0.0000000000000000000000003035 112.0
HFD2_k127_6314214_3 ABC transporter substrate binding protein - - - 0.0000000000000000004382 98.0
HFD2_k127_6314214_4 X-Pro dipeptidyl-peptidase (S15 family) K06889,K07397 - - 0.0000002631 55.0
HFD2_k127_6322544_0 Mur ligase family, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 608.0
HFD2_k127_6322544_1 proteins, homologs of microcin C7 resistance protein MccF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 334.0
HFD2_k127_6322544_2 Protein of unknown function (DUF1499) - - - 0.0000000000000000000000000000000000000000000000000000000009682 209.0
HFD2_k127_6322544_3 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000000000000000000000004394 187.0
HFD2_k127_6322544_4 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000002296 183.0
HFD2_k127_6322544_5 - - - - 0.0000000000000000000000001001 111.0
HFD2_k127_6322544_6 Transglycosylase associated protein - - - 0.00000000000000005256 84.0
HFD2_k127_6322544_7 - - - - 0.000000001348 65.0
HFD2_k127_6322544_8 SnoaL-like domain - - - 0.0001088 45.0
HFD2_k127_6325490_0 Cysteine-rich domain - - - 2.804e-209 663.0
HFD2_k127_6325490_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 456.0
HFD2_k127_6325490_2 COG1592 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008096 258.0
HFD2_k127_6325490_3 Belongs to the Fur family K09826 - - 0.000000000000000000000000000000000000000000000000002674 185.0
HFD2_k127_6325490_4 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000005683 180.0
HFD2_k127_6325490_5 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000002375 108.0
HFD2_k127_6327326_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1077.0
HFD2_k127_6327326_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 308.0
HFD2_k127_6327326_2 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000007118 194.0
HFD2_k127_6327326_3 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000001416 191.0
HFD2_k127_6327326_4 Pyridoxamine 5'-phosphate oxidase like - - - 0.00000000000000000000000000000000000000006517 156.0
HFD2_k127_6327326_5 HD domain - - - 0.00000000000000000001154 98.0
HFD2_k127_6327326_6 Putative TM nitroreductase - - - 0.0000000000001079 81.0
HFD2_k127_6377864_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 6.218e-225 716.0
HFD2_k127_6377864_1 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 398.0
HFD2_k127_6377864_2 Malate/L-lactate dehydrogenase K13574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 290.0
HFD2_k127_6377864_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005304 265.0
HFD2_k127_6377864_4 TfoX N-terminal domain K07343 - - 0.00000000000000002521 89.0
HFD2_k127_6377864_5 Ribbon-helix-helix domain - - - 0.000000000000001586 79.0
HFD2_k127_6378546_0 ATPases associated with a variety of cellular activities K01995,K11957 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 341.0
HFD2_k127_6378546_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15270 - - 0.000000000000000000000000000000001131 134.0
HFD2_k127_6378546_2 amino acid ABC transporter K01996 - - 0.00000000000000000000000000000002866 132.0
HFD2_k127_638096_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 419.0
HFD2_k127_638096_1 CoA-transferase family III K01796 - 5.1.99.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 359.0
HFD2_k127_638096_2 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000006899 205.0
HFD2_k127_638096_3 NnrU protein - - - 0.00000000000000000000000000000000000000000000000000000005471 205.0
HFD2_k127_638096_4 TAP-like protein - - - 0.00000000000000000000000000000000000000000007811 183.0
HFD2_k127_638096_5 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000002795 131.0
HFD2_k127_638096_6 Belongs to the UPF0235 family K09131 - - 0.000000000000000000000003853 111.0
HFD2_k127_638096_7 YGGT family K02221 - - 0.00000000000000000000379 96.0
HFD2_k127_638096_8 PFAM Usg family protein - - - 0.00000000000002992 72.0
HFD2_k127_6391880_0 Putative Na+/H+ antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 516.0
HFD2_k127_6391880_1 Malic enzyme K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 321.0
HFD2_k127_6391880_10 - - - - 0.0000000000000002477 81.0
HFD2_k127_6391880_11 Cupin - - - 0.000000002817 64.0
HFD2_k127_6391880_13 Histidine kinase - - - 0.0004761 48.0
HFD2_k127_6391880_15 DoxX K15977 - - 0.0005763 44.0
HFD2_k127_6391880_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 306.0
HFD2_k127_6391880_3 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000644 265.0
HFD2_k127_6391880_4 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005014 266.0
HFD2_k127_6391880_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001976 243.0
HFD2_k127_6391880_6 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000006504 235.0
HFD2_k127_6391880_7 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000001672 206.0
HFD2_k127_6391880_8 helix_turn_helix, Lux Regulon K14987 - - 0.00000000000000000000000000000000000000000000003764 183.0
HFD2_k127_6391880_9 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.0000000000000000000000001262 110.0
HFD2_k127_6393028_0 Arac family - - - 0.0000000000000000000000000000000000000000000000000803 191.0
HFD2_k127_6393028_1 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.000000000000000000000000000000000000000000004814 173.0
HFD2_k127_6393028_2 Carbon-nitrogen hydrolase K01502 - 3.5.5.7 0.00000000000000000000000000000000000000000008568 166.0
HFD2_k127_6417624_0 COG0744 Membrane carboxypeptidase (penicillin-binding protein) K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008351 563.0
HFD2_k127_6417624_1 Sugar (and other) transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 314.0
HFD2_k127_6417624_2 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000004492 160.0
HFD2_k127_6417624_3 protein conserved in bacteria K01876 - 6.1.1.12 0.000000000000000000000000000000000000000001797 162.0
HFD2_k127_6417624_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.000000000007808 70.0
HFD2_k127_6431497_0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 352.0
HFD2_k127_6431497_1 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 326.0
HFD2_k127_6431497_2 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000000000000000000000000008868 221.0
HFD2_k127_6431497_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000006005 231.0
HFD2_k127_6431497_4 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000005715 191.0
HFD2_k127_6431497_5 Transcriptional regulator K13771 - - 0.0000000000000000000000000000000000000000006876 162.0
HFD2_k127_6431497_6 - - - - 0.0000000000000000000002736 102.0
HFD2_k127_6431497_7 LTXXQ motif family protein - - - 0.0000000000000000000009955 103.0
HFD2_k127_6431497_8 - - - - 0.00000000000000001884 91.0
HFD2_k127_6431497_9 Protein of unknown function (DUF2933) - - - 0.00000000000000003271 93.0
HFD2_k127_6441470_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 3.135e-197 622.0
HFD2_k127_6441470_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 413.0
HFD2_k127_6441470_2 Protein of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 360.0
HFD2_k127_6441470_3 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.0000000000000961 71.0
HFD2_k127_6453653_0 Homotrimeric ring hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006054 533.0
HFD2_k127_6453653_1 Serine aminopeptidase, S33 K10216,K18092 - 3.7.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 323.0
HFD2_k127_6453653_2 ABC transporter, ATP-binding protein K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001854 267.0
HFD2_k127_6453653_3 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003038 259.0
HFD2_k127_6453653_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000006429 243.0
HFD2_k127_6453653_5 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000005409 187.0
HFD2_k127_6453653_6 Rieske-like [2Fe-2S] domain K16304 - - 0.0000000000000000000000767 101.0
HFD2_k127_6453653_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000221 93.0
HFD2_k127_650284_0 hydrolase of the metallo-beta-lactamase superfamily K12574 - - 7.741e-197 627.0
HFD2_k127_650284_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 427.0
HFD2_k127_650284_2 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000002548 239.0
HFD2_k127_650284_3 Protein of unknown function (DUF1467) - - - 0.0000000000000004233 82.0
HFD2_k127_6537210_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 307.0
HFD2_k127_6537210_1 PFAM cobalamin B12-binding domain protein K01849 - 5.4.99.2 0.0000000000000000000003931 101.0
HFD2_k127_6537210_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000005079 55.0
HFD2_k127_6546452_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 549.0
HFD2_k127_6546452_1 Bacterial extracellular solute-binding protein K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 392.0
HFD2_k127_6546452_2 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 322.0
HFD2_k127_6546452_3 ABC-type tungstate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 283.0
HFD2_k127_6546452_4 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002781 290.0
HFD2_k127_6546452_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001585 289.0
HFD2_k127_6546452_6 Molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000002627 252.0
HFD2_k127_6546452_7 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000001537 245.0
HFD2_k127_6546452_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000001019 234.0
HFD2_k127_6548944_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 528.0
HFD2_k127_6548944_1 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 446.0
HFD2_k127_6548944_2 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 392.0
HFD2_k127_6548944_3 Dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000003701 194.0
HFD2_k127_6599906_0 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 334.0
HFD2_k127_6599906_1 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 326.0
HFD2_k127_6599906_2 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 305.0
HFD2_k127_6599906_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000004621 143.0
HFD2_k127_6599906_4 Protein of unknown function (DUF3303) - - - 0.000000000000000000000000000000000006214 138.0
HFD2_k127_6599906_5 transport system periplasmic component K01989 - - 0.00005575 51.0
HFD2_k127_6607104_0 ABC-type multidrug transport system, ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 560.0
HFD2_k127_6607104_1 Voltage-dependent anion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 387.0
HFD2_k127_6607104_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003163 255.0
HFD2_k127_6607104_3 Cold shock K03704 - - 0.00000000000000000000000000002266 117.0
HFD2_k127_6607104_4 - - - - 0.00000000009909 70.0
HFD2_k127_6607106_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 458.0
HFD2_k127_6607106_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 441.0
HFD2_k127_6635162_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000845 219.0
HFD2_k127_6635162_1 PAP2 superfamily - - - 0.00000002922 62.0
HFD2_k127_6635540_0 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006417 322.0
HFD2_k127_6635540_1 methyltransferase activity K21310 - 2.1.1.334 0.00000000000000000000000000000000000000000000000000000000000000000002871 235.0
HFD2_k127_6635540_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000002721 191.0
HFD2_k127_6635540_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000001077 158.0
HFD2_k127_6635540_4 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000000000000000000001341 105.0
HFD2_k127_6635540_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000000000000000000137 111.0
HFD2_k127_6635540_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000001326 104.0
HFD2_k127_6699111_0 CoA-transferase family III K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 445.0
HFD2_k127_6699111_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 299.0
HFD2_k127_6699111_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006424 289.0
HFD2_k127_6699111_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 286.0
HFD2_k127_6699111_4 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000002021 178.0
HFD2_k127_6724199_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 383.0
HFD2_k127_6724199_1 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000003491 235.0
HFD2_k127_6724199_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000002856 58.0
HFD2_k127_6733089_0 Phytoene dehydrogenase-like oxidoreductase - - - 2.521e-196 631.0
HFD2_k127_6733089_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 526.0
HFD2_k127_6733089_10 Protein of unknown function (DUF3828) - - - 0.0000000004038 68.0
HFD2_k127_6733089_2 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000699 498.0
HFD2_k127_6733089_3 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006473 266.0
HFD2_k127_6733089_4 thiamine-containing compound biosynthetic process K02051 - - 0.0000000000000000000000000000000000000000000000000000000000001362 224.0
HFD2_k127_6733089_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000002265 226.0
HFD2_k127_6733089_6 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000002882 214.0
HFD2_k127_6733089_7 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000000000000001698 166.0
HFD2_k127_6733089_8 transcriptional regulator - - - 0.000000000000000000000000000000008808 135.0
HFD2_k127_6733089_9 Ring hydroxylating beta subunit - - - 0.000000000000000000000006927 114.0
HFD2_k127_6743896_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1232.0
HFD2_k127_6743896_1 Membrane-bound lytic murein transglycosylase B K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 391.0
HFD2_k127_6743896_2 Lytic murein transglycosylase K08305 - - 0.00000000000000000000000000000000000000000000000000000006415 211.0
HFD2_k127_6743958_0 Dehydrogenase K16877 - 1.3.99.8 3.151e-271 846.0
HFD2_k127_6743958_1 PFAM Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 518.0
HFD2_k127_6743958_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 481.0
HFD2_k127_6743958_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 371.0
HFD2_k127_6743958_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 312.0
HFD2_k127_6743958_5 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000003651 191.0
HFD2_k127_6743958_6 dimethylargininase activity K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000165 166.0
HFD2_k127_6743958_7 ATPases associated with a variety of cellular activities K01995 - - 0.000000000000000009071 96.0
HFD2_k127_6751059_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 447.0
HFD2_k127_6751059_1 COG1607 Acyl-CoA hydrolase K10806 - - 0.00000000000000218 78.0
HFD2_k127_6756344_0 Fumarylacetoacetate (FAA) hydrolase family K02509 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003501 244.0
HFD2_k127_6756344_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000001776 147.0
HFD2_k127_6756344_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000006783 140.0
HFD2_k127_6769341_0 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 443.0
HFD2_k127_6769341_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 428.0
HFD2_k127_6769341_2 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 404.0
HFD2_k127_6769341_3 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 325.0
HFD2_k127_6769341_4 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002965 263.0
HFD2_k127_6791480_0 histidine ammonia-lyase activity K01745 - 4.3.1.3 7.952e-194 616.0
HFD2_k127_6791480_1 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003403 268.0
HFD2_k127_6791480_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000008534 232.0
HFD2_k127_6791480_3 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.000000000000000000000000000000000000000000000000000000000001048 221.0
HFD2_k127_6791480_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000002165 211.0
HFD2_k127_6791480_5 AraC-like ligand binding domain - - - 0.00000000000000000000000000000006412 134.0
HFD2_k127_6791480_7 Belongs to the 'phage' integrase family - - - 0.00005401 46.0
HFD2_k127_6829031_0 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005078 273.0
HFD2_k127_6829031_1 NIPSNAP - - - 0.00000000000000000000000000000000000000002808 168.0
HFD2_k127_6829031_2 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000000002621 137.0
HFD2_k127_6829031_3 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000000000000002706 133.0
HFD2_k127_6829031_4 acid phosphatase activity K03651,K11175 - 2.1.2.2,3.1.4.53 0.00000519 49.0
HFD2_k127_6862265_0 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 458.0
HFD2_k127_6862265_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 425.0
HFD2_k127_6862265_2 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 403.0
HFD2_k127_687742_0 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007877 277.0
HFD2_k127_687742_1 Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000000000000000000000001008 166.0
HFD2_k127_687742_2 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000001324 134.0
HFD2_k127_6896152_0 Domain of unknown function (DUF4139) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 315.0
HFD2_k127_6896152_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002973 256.0
HFD2_k127_6899392_0 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 373.0
HFD2_k127_6899392_1 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 349.0
HFD2_k127_6899392_2 overlaps another CDS with the same product name - - - 0.00000000000000000000000116 118.0
HFD2_k127_6929643_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.78e-302 934.0
HFD2_k127_6929643_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 580.0
HFD2_k127_6934528_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.769e-257 803.0
HFD2_k127_6934528_1 EVE domain - - - 0.000000000000000000000000000000000000000000000000008242 186.0
HFD2_k127_6934528_2 Prokaryotic cytochrome b561 K12262 - - 0.00000000000000000000000000000000005152 140.0
HFD2_k127_6934528_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000002213 124.0
HFD2_k127_6937198_0 Glutaminyl-tRNA synthetase K01886 - 6.1.1.18 2.395e-297 921.0
HFD2_k127_6937198_1 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 444.0
HFD2_k127_6937198_2 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 339.0
HFD2_k127_6937198_3 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 287.0
HFD2_k127_6937198_4 Bacterial SH3 domain - - - 0.00000000000000000000000000000000001416 148.0
HFD2_k127_6947624_0 lactoylglutathione lyase activity K08234 - - 0.00000000000000000000000000000000000000000000001076 183.0
HFD2_k127_6947624_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000001648 179.0
HFD2_k127_6947624_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000001421 106.0
HFD2_k127_6953656_0 L-phenylalanine transmembrane transporter activity K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 336.0
HFD2_k127_6953656_1 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 286.0
HFD2_k127_6953656_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009224 287.0
HFD2_k127_6953656_3 ABC transporter, ATP-binding protein K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002851 285.0
HFD2_k127_6953656_4 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000004609 154.0
HFD2_k127_6953656_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000007676 70.0
HFD2_k127_6959146_0 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 319.0
HFD2_k127_6959146_1 Protein of unknown function (DUF2794) - - - 0.0000000000000000000001829 101.0
HFD2_k127_6959146_2 - - - - 0.0000000000001738 78.0
HFD2_k127_6969765_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004098 330.0
HFD2_k127_6969765_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K10617 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 301.0
HFD2_k127_6969765_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000189 161.0
HFD2_k127_7017918_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 398.0
HFD2_k127_7017918_1 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 329.0
HFD2_k127_7017918_2 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000001077 145.0
HFD2_k127_7020840_0 Domain of unknown function (DUF1849) - - - 0.0000000000000000000000000000000004466 144.0
HFD2_k127_7020840_1 Domain of unknown function (DUF1849) - - - 0.000005306 55.0
HFD2_k127_7027074_0 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 427.0
HFD2_k127_7027074_1 Phosphoesterase family K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000002482 175.0
HFD2_k127_7028969_0 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 329.0
HFD2_k127_7028969_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006303 273.0
HFD2_k127_7028969_2 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002836 276.0
HFD2_k127_7028969_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000005508 231.0
HFD2_k127_7028969_4 TetR family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000005637 202.0
HFD2_k127_7028969_6 cytochrome P-450 - - - 0.000000000000000000000000000000000000000000004101 169.0
HFD2_k127_7028969_7 Cytochrome c - - - 0.0000000000002715 74.0
HFD2_k127_7028969_8 TPR repeat-containing protein - - - 0.00000000005006 72.0
HFD2_k127_7042803_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000001623 134.0
HFD2_k127_7042803_1 - - - - 0.000004477 59.0
HFD2_k127_7062454_0 COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 327.0
HFD2_k127_7062454_1 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 323.0
HFD2_k127_7062454_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000001056 135.0
HFD2_k127_7064768_0 TrkA-C domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 596.0
HFD2_k127_7064768_1 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001039 238.0
HFD2_k127_707270_0 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.746e-274 852.0
HFD2_k127_707270_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 405.0
HFD2_k127_7084515_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000001092 182.0
HFD2_k127_7084515_1 FCD - - - 0.00000000000000000000000000002741 126.0
HFD2_k127_7084515_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15065 - - 0.0000000000000000000003241 101.0
HFD2_k127_7084515_3 Alcohol dehydrogenase GroES-like domain - - - 0.00000005602 57.0
HFD2_k127_7090274_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 2.147e-202 643.0
HFD2_k127_7090274_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 498.0
HFD2_k127_7090274_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000001348 207.0
HFD2_k127_7090274_3 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000005761 162.0
HFD2_k127_7090274_4 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000007964 152.0
HFD2_k127_7090274_5 COG4942 Membrane-bound metallopeptidase - - - 0.00000000000006296 79.0
HFD2_k127_7097520_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 452.0
HFD2_k127_7097520_1 Iron-containing alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001036 269.0
HFD2_k127_7097520_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.0000000000000000000000000000000000007723 146.0
HFD2_k127_7113328_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 491.0
HFD2_k127_7113328_1 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 407.0
HFD2_k127_7113328_2 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001396 273.0
HFD2_k127_7114516_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 616.0
HFD2_k127_7114516_1 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 344.0
HFD2_k127_7123224_0 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 396.0
HFD2_k127_7123224_1 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 372.0
HFD2_k127_7123224_2 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 334.0
HFD2_k127_7123224_3 protein conserved in bacteria K09796 - - 0.0000000000000000000000000000000001608 138.0
HFD2_k127_7123224_4 NMT1-like family K02051 - - 0.0007844 42.0
HFD2_k127_7130106_0 Rieske 2Fe-2S - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 359.0
HFD2_k127_7130106_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007543 252.0
HFD2_k127_7130106_2 - - - - 0.0000000000000000000000000005334 115.0
HFD2_k127_7130416_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 7.577e-220 714.0
HFD2_k127_7130416_1 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 409.0
HFD2_k127_7130416_2 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 316.0
HFD2_k127_7130416_3 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000004005 184.0
HFD2_k127_7130416_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000001101 63.0
HFD2_k127_7132139_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008622 550.0
HFD2_k127_7132139_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000005728 156.0
HFD2_k127_7139768_0 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101,K05713 - 1.13.11.16,1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 344.0
HFD2_k127_7139768_1 Cupin domain K00450 - 1.13.11.4 0.00000000000000000000000000000000000000002067 160.0
HFD2_k127_7139768_2 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000008895 142.0
HFD2_k127_7139768_3 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.00000000000000000000001987 105.0
HFD2_k127_7139768_4 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01895 - 6.2.1.1 0.00001185 57.0
HFD2_k127_7148583_0 Adenylate cyclase - - - 1.201e-199 642.0
HFD2_k127_7148583_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 493.0
HFD2_k127_7148583_2 FR47-like protein - - - 0.000000000000000000000009985 104.0
HFD2_k127_7151690_0 Aspartate tyrosine aromatic aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006473 543.0
HFD2_k127_7151690_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 318.0
HFD2_k127_7151690_2 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 311.0
HFD2_k127_7151690_3 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 295.0
HFD2_k127_7151690_4 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006022 271.0
HFD2_k127_7151690_5 ABC transporter K15600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000714 262.0
HFD2_k127_7151690_6 aminotransferase class I and II K12252 - 2.6.1.84 0.00000000000000000000000000000000000000000000000000000000000000000001452 235.0
HFD2_k127_7151690_7 - - - - 0.0000000000000000000000000000000000000000000000000004196 201.0
HFD2_k127_7151690_8 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15598 - - 0.00000000000000000002539 93.0
HFD2_k127_7153633_0 PFAM Bacterial protein of - - - 0.000000000000000000000000000000000000000000003291 167.0
HFD2_k127_7153633_1 Glycosyltransferase like family 2 - - - 0.000000000002694 79.0
HFD2_k127_7154300_0 Hydantoinase/oxoprolinase N-terminal region K01469 - 3.5.2.9 0.0 1078.0
HFD2_k127_7154300_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 6.016e-196 622.0
HFD2_k127_7154300_10 - - - - 0.000000000000000000001226 106.0
HFD2_k127_7154300_11 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000001368 86.0
HFD2_k127_7154300_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007865 584.0
HFD2_k127_7154300_3 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 467.0
HFD2_k127_7154300_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006971 354.0
HFD2_k127_7154300_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 323.0
HFD2_k127_7154300_6 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000001254 255.0
HFD2_k127_7154300_7 Catalytic LigB subunit of aromatic ring-opening dioxygenase K00455 - 1.13.11.15 0.000000000000000000000000000000000000000000000001818 184.0
HFD2_k127_7154300_8 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000001042 129.0
HFD2_k127_7154300_9 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.00000000000000000000004019 109.0
HFD2_k127_7155783_0 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 343.0
HFD2_k127_7155783_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 344.0
HFD2_k127_7155783_2 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.0000000000000000000000000000000000000000000002289 171.0
HFD2_k127_7170949_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 353.0
HFD2_k127_7170949_1 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000000000000000000000000000000000000000001095 237.0
HFD2_k127_7170949_2 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000001134 225.0
HFD2_k127_7170949_3 - - - - 0.00000000000000000000000000000000000002335 158.0
HFD2_k127_7170949_4 FecR protein - - - 0.0000000000000000000000000000002969 134.0
HFD2_k127_7170949_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000001869 121.0
HFD2_k127_7172622_0 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 375.0
HFD2_k127_7172622_1 Major Facilitator Superfamily - - - 0.0000000000003038 72.0
HFD2_k127_7174503_0 Protein conserved in bacteria K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 308.0
HFD2_k127_7174503_1 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000002421 264.0
HFD2_k127_7176969_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 447.0
HFD2_k127_7176969_1 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 339.0
HFD2_k127_7176969_2 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 316.0
HFD2_k127_7176969_3 FecR protein - - - 0.000000000000000000000000000001003 133.0
HFD2_k127_7176969_4 FecR protein - - - 0.0000000000000000000000000007224 119.0
HFD2_k127_7176969_5 PFAM Transglycosylase-associated protein - - - 0.0000000000000000000000005476 106.0
HFD2_k127_7182029_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 372.0
HFD2_k127_7182029_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 311.0
HFD2_k127_7182029_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009125 275.0
HFD2_k127_7182624_0 ATPase (AAA K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 413.0
HFD2_k127_7182624_1 NADPH-dependent FMN reductase K19784 - - 0.000000000000000000000000000000000000000000000000000000000008704 223.0
HFD2_k127_7182624_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000005787 133.0
HFD2_k127_7182624_4 Preprotein translocase subunit YajC K03210 - - 0.0000000000000000000000000001886 119.0
HFD2_k127_7182624_5 Evidence 4 Homologs of previously reported genes of K07461 - - 0.0000000000000000000000000004019 117.0
HFD2_k127_7182624_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000001319 98.0
HFD2_k127_7188416_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 389.0
HFD2_k127_7188416_1 CHASE - - - 0.0001424 52.0
HFD2_k127_7191067_0 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 319.0
HFD2_k127_7191067_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 307.0
HFD2_k127_7191067_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 302.0
HFD2_k127_7191067_3 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007807 245.0
HFD2_k127_7191067_4 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000006908 202.0
HFD2_k127_7191067_5 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.0000000000000000000000000000866 121.0
HFD2_k127_7191067_6 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.0000000005986 61.0
HFD2_k127_7197179_0 SMART Elongator protein 3 MiaB NifB - - - 8.431e-246 767.0
HFD2_k127_7197179_1 cysteine synthase K01697 - 4.2.1.22 2.905e-204 646.0
HFD2_k127_7197179_2 cystathionine K01739,K01758 - 2.5.1.48,4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 589.0
HFD2_k127_7197179_3 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 524.0
HFD2_k127_7197179_4 Carbon-nitrogen hydrolase K01501,K01502 - 3.5.5.1,3.5.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 456.0
HFD2_k127_7197179_5 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 353.0
HFD2_k127_7197179_6 membrane - - - 0.0000000000000000000000000000000000003238 147.0
HFD2_k127_7197179_7 - - - - 0.000000000000003539 82.0
HFD2_k127_7200127_0 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 321.0
HFD2_k127_7200127_1 Rieske 2Fe-2S domain protein K14748 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000176 266.0
HFD2_k127_7200127_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000002476 246.0
HFD2_k127_7200127_3 Ring hydroxylating subunit beta family protein 1 - - - 0.0000000000000000000000000000007814 129.0
HFD2_k127_7201855_0 AMP-binding enzyme K01897 - 6.2.1.3 2.214e-195 629.0
HFD2_k127_7214464_0 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 314.0
HFD2_k127_7214464_1 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 290.0
HFD2_k127_7214464_2 PFAM binding-protein-dependent transport systems inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000003024 237.0
HFD2_k127_7214464_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000009315 226.0
HFD2_k127_7214464_4 PFAM binding-protein-dependent transport systems inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000001322 203.0
HFD2_k127_7229986_0 Cell division protein FtsI penicillin-binding protein 2 K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 623.0
HFD2_k127_7229986_1 Rod shape-determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006537 576.0
HFD2_k127_7229986_2 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000007297 194.0
HFD2_k127_7229986_3 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000009716 136.0
HFD2_k127_7229986_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000009509 124.0
HFD2_k127_7229986_5 shape-determining protein K03571 - - 0.000000000000000000000001561 116.0
HFD2_k127_7231072_0 AMP-binding enzyme C-terminal domain K00666 - - 5.182e-232 728.0
HFD2_k127_7231072_1 Isochorismatase family K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 354.0
HFD2_k127_7231072_2 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 315.0
HFD2_k127_7231072_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000366 153.0
HFD2_k127_7231072_4 Belongs to the bacterial histone-like protein family K03530 - - 0.00000000000000000000000000000003878 130.0
HFD2_k127_7241447_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 396.0
HFD2_k127_7241447_1 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000133 265.0
HFD2_k127_7241447_11 PFAM Uncharacterised protein family UPF0150 - - - 0.0000264 51.0
HFD2_k127_7241447_2 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000000000000000000005249 193.0
HFD2_k127_7241447_3 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000000000000000000000003051 182.0
HFD2_k127_7241447_4 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000004908 172.0
HFD2_k127_7241447_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000006547 168.0
HFD2_k127_7241447_6 Bacterial transcriptional regulator - - - 0.0000000000000000000000000000005294 134.0
HFD2_k127_7241447_7 MaoC like domain - - - 0.000000000000000000000000008666 116.0
HFD2_k127_7241447_8 Protein of unknown function (DUF1150) - - - 0.0000000000000005609 80.0
HFD2_k127_7241447_9 Major facilitator superfamily K08218 - - 0.000000000003128 78.0
HFD2_k127_7257807_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 4.798e-225 719.0
HFD2_k127_7257807_1 Hemimethylated DNA-binding protein YccV like K11940 - - 0.00000000000000000000000000000000000000000002072 173.0
HFD2_k127_7264771_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 4.189e-230 736.0
HFD2_k127_7264771_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 474.0
HFD2_k127_7264771_2 transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008645 256.0
HFD2_k127_7264771_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.0000000000000000000000000000000000000000000000000000000000000000161 233.0
HFD2_k127_7264771_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000001339 225.0
HFD2_k127_7264771_5 Domain of unknown function (DUF1989) - - - 0.000000000000000000000000000000001513 140.0
HFD2_k127_7264771_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000001788 132.0
HFD2_k127_7264771_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000007671 126.0
HFD2_k127_7271662_0 Acyl-CoA dehydrogenase, N-terminal domain K00252 - 1.3.8.6 5.376e-221 690.0
HFD2_k127_7271662_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 402.0
HFD2_k127_7271662_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000121 246.0
HFD2_k127_7276662_0 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 298.0
HFD2_k127_7276662_1 carbamoyl transferase, NodU family K00612 - - 0.0000000000000000000000000000000000000000000000000004669 184.0
HFD2_k127_7276662_2 protein involved in response to NO K07234 - - 0.00000000000000000000000000000000000006505 149.0
HFD2_k127_7312_0 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 542.0
HFD2_k127_7312_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 484.0
HFD2_k127_7312_2 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 456.0
HFD2_k127_7312_3 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000011 284.0
HFD2_k127_7312_4 Belongs to the hyi family K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000002163 261.0
HFD2_k127_7312_5 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000002812 169.0
HFD2_k127_7312_6 Putative prokaryotic signal transducing protein - - - 0.00000000000000949 84.0
HFD2_k127_7312_7 - - - - 0.00000000000001208 80.0
HFD2_k127_7312825_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 408.0
HFD2_k127_7312825_1 Abc transporter K05833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009886 284.0
HFD2_k127_7312825_2 PFAM Branched-chain amino acid transport system permease component K05832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001844 252.0
HFD2_k127_7312825_3 PFAM ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000003623 242.0
HFD2_k127_7312825_4 Ring hydroxylating subunit beta family protein 1 - - - 0.000000000000000000000000000000000273 147.0
HFD2_k127_7314573_0 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 550.0
HFD2_k127_7314573_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001072 287.0
HFD2_k127_7314573_2 Domain of unknown function (DUF4070) - - - 0.0000000000000000000000000000000000000000000000000000000007344 209.0
HFD2_k127_7314573_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000009977 200.0
HFD2_k127_7314573_4 - - - - 0.000000000000000000000000000000000000583 153.0
HFD2_k127_7314573_5 - - - - 0.0000000000000003113 92.0
HFD2_k127_7327731_0 RNA polymerase sigma K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 420.0
HFD2_k127_7327731_1 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 319.0
HFD2_k127_7327731_2 nitrilase K01501,K01502 - 3.5.5.1,3.5.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000008923 246.0
HFD2_k127_7327731_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000002592 147.0
HFD2_k127_7353084_0 AcrB/AcrD/AcrF family K03296,K07788,K07789,K21133 - - 0.0 1174.0
HFD2_k127_7353084_1 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 435.0
HFD2_k127_7353084_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 385.0
HFD2_k127_7353084_3 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 358.0
HFD2_k127_7353084_4 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000002247 215.0
HFD2_k127_7366541_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.335e-201 642.0
HFD2_k127_7366541_1 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 537.0
HFD2_k127_7366541_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000137 166.0
HFD2_k127_7366541_3 - - - - 0.000000000000000000000000000005462 127.0
HFD2_k127_7369978_0 Hydantoinase B/oxoprolinase - - - 6.074e-270 841.0
HFD2_k127_7369978_1 Hydantoinase/oxoprolinase - - - 1.771e-245 772.0
HFD2_k127_7369978_2 Hydantoinase/oxoprolinase - - - 0.000000000000000000000000000000000000000004691 158.0
HFD2_k127_7369978_3 PilZ domain - - - 0.00000000002752 69.0
HFD2_k127_7384372_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 1346.0
HFD2_k127_7384372_1 Major Facilitator Superfamily K02575 - - 1.727e-213 672.0
HFD2_k127_7384372_2 Major Facilitator Superfamily K02575 - - 8.538e-209 657.0
HFD2_k127_7384372_3 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000001419 202.0
HFD2_k127_7384372_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K13642 - - 0.0000000000000000000000000000000000000000000000000001286 193.0
HFD2_k127_7387924_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.3e-237 741.0
HFD2_k127_7387924_1 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 336.0
HFD2_k127_7389699_0 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 313.0
HFD2_k127_7389699_1 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000005071 231.0
HFD2_k127_7390627_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 304.0
HFD2_k127_7390627_1 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001517 282.0
HFD2_k127_7390627_2 Chromate K07240 - - 0.000000000000000000004359 94.0
HFD2_k127_7396703_0 Two component transcriptional regulator, winged helix family K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 349.0
HFD2_k127_7396703_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 355.0
HFD2_k127_7396703_2 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.000000000000000000000000000000000003569 138.0
HFD2_k127_7396703_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000003447 135.0
HFD2_k127_7415060_0 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 323.0
HFD2_k127_7415060_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000005705 95.0
HFD2_k127_7418070_0 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 325.0
HFD2_k127_7418070_1 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000000000000000000000000000001165 207.0
HFD2_k127_7418070_2 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000397 209.0
HFD2_k127_7418070_3 AAA domain - - - 0.0000000000000000000000000000000000000000002487 162.0
HFD2_k127_7418070_4 Trm112p-like protein K09791 - - 0.00000000000000000002201 93.0
HFD2_k127_7418070_5 - - - - 0.0001815 45.0
HFD2_k127_7429970_0 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 1.493e-294 923.0
HFD2_k127_7429970_1 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 0.0000000000000000009169 92.0
HFD2_k127_743441_0 aminopeptidase N K01256 - 3.4.11.2 3.295e-301 935.0
HFD2_k127_743441_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 468.0
HFD2_k127_743441_2 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000003935 217.0
HFD2_k127_743441_3 PFAM Glutathione S-transferase domain - - - 0.0000000000000000000000000000000000000000000000001997 183.0
HFD2_k127_743441_4 Phasin protein - - - 0.00000000000000000001045 98.0
HFD2_k127_743441_5 Small protein - - - 0.000000000002031 69.0
HFD2_k127_7434548_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 470.0
HFD2_k127_7434548_1 3-beta hydroxysteroid dehydrogenase/isomerase family K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 441.0
HFD2_k127_7434548_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000292 248.0
HFD2_k127_7439650_0 lysyl-tRNA synthetase K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 451.0
HFD2_k127_7439650_1 Lysine-2,3-aminomutase K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000366 252.0
HFD2_k127_7439650_2 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000002969 178.0
HFD2_k127_7469314_0 PFAM Glycosyl transferase family 2 K03669 - - 1.929e-213 682.0
HFD2_k127_7469314_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 355.0
HFD2_k127_7469314_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00573 - 2.1.1.77 0.000000000000000000000002702 106.0
HFD2_k127_7476031_0 Major facilitator superfamily - - - 3.722e-215 691.0
HFD2_k127_7476031_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 489.0
HFD2_k127_7476031_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000006912 220.0
HFD2_k127_7476031_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000001822 162.0
HFD2_k127_7476031_4 thioesterase K07107 - - 0.00000000000000000000000000000000000001383 149.0
HFD2_k127_7476031_5 COG0811 Biopolymer transport proteins K03562 - - 0.00000000000000000000000000000003111 134.0
HFD2_k127_7476031_6 - - - - 0.0000000000000000000001069 107.0
HFD2_k127_7476031_7 Protein of unknown function (DUF1328) - - - 0.00000000000009588 72.0
HFD2_k127_7476031_8 peptidyl-tyrosine sulfation - - - 0.00000000002806 72.0
HFD2_k127_7483272_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 465.0
HFD2_k127_7483272_1 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 286.0
HFD2_k127_7483272_2 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.0000000000000000000000000000000000000000000199 164.0
HFD2_k127_7483272_3 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000000001268 159.0
HFD2_k127_7487086_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 397.0
HFD2_k127_7487086_1 rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000004089 168.0
HFD2_k127_7487086_2 Protein of unknown function (DUF3752) - - - 0.00000000000000000000000000002685 124.0
HFD2_k127_7487086_3 Protein of unknown function (DUF3754) - - - 0.0000000000000000000000000226 111.0
HFD2_k127_7501648_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 2.9e-203 647.0
HFD2_k127_7501648_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 439.0
HFD2_k127_7501648_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000009335 210.0
HFD2_k127_7501648_3 - - - - 0.0000000007311 63.0
HFD2_k127_7520039_0 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 349.0
HFD2_k127_7520039_1 Nitrogen fixation protein fixG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001985 261.0
HFD2_k127_7520039_2 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.000000000000000000000000000000000001696 140.0
HFD2_k127_7520039_3 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.0000000002512 63.0
HFD2_k127_7521603_0 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 536.0
HFD2_k127_7532468_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 432.0
HFD2_k127_7532468_1 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000001001 269.0
HFD2_k127_7532468_2 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000003285 112.0
HFD2_k127_7532468_3 Lipopolysaccharide-assembly K03643 - - 0.00000000000000000004365 97.0
HFD2_k127_7545032_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 6.157e-208 660.0
HFD2_k127_7545032_1 Major facilitator superfamily - - - 0.000000000000000000000000000002283 128.0
HFD2_k127_7548515_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 1.044e-274 862.0
HFD2_k127_7548515_1 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 492.0
HFD2_k127_7548515_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 464.0
HFD2_k127_7548515_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 411.0
HFD2_k127_7548515_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008764 359.0
HFD2_k127_7548515_5 branched-chain amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001238 245.0
HFD2_k127_7550152_0 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 543.0
HFD2_k127_7550152_1 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 358.0
HFD2_k127_7550152_2 NQR2, RnfD, RnfE family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000203 272.0
HFD2_k127_7550152_3 Cupin domain - - - 0.000000000000000000000000000000000004382 150.0
HFD2_k127_7550152_4 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000006901 131.0
HFD2_k127_7561132_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 2.078e-230 721.0
HFD2_k127_7561132_1 Histidine kinase K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 340.0
HFD2_k127_7561132_2 Domain of unknown function (DUF1993) K09983 - - 0.0000000000000000000000000000000000000000000000000000002407 218.0
HFD2_k127_7561646_0 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006942 308.0
HFD2_k127_7561646_1 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004153 278.0
HFD2_k127_7584928_0 COG1525 Micrococcal nuclease (thermonuclease) homologs - - - 0.0000000000000000000000000000000415 130.0
HFD2_k127_7587059_0 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000227 256.0
HFD2_k127_7587059_1 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000009853 51.0
HFD2_k127_7608491_0 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008656 610.0
HFD2_k127_7635218_0 Oxidoreductase NAD-binding domain K15511 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 530.0
HFD2_k127_7635218_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002335 250.0
HFD2_k127_7635218_2 Universal stress protein UspA - - - 0.000000000000000000000000000000000000000000000000000001292 201.0
HFD2_k127_7635218_3 - - - - 0.0000002301 59.0
HFD2_k127_7642350_0 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.0000000000000000000000000000000000000000000000000000001069 203.0
HFD2_k127_7642350_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15270 - - 0.0000000000000000000000000000000000000000001672 166.0
HFD2_k127_7690627_0 Belongs to the DEAD box helicase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 535.0
HFD2_k127_7690627_1 Twin-arginine translocation pathway signal sequence - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 385.0
HFD2_k127_7690627_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002901 279.0
HFD2_k127_7690627_3 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000005869 231.0
HFD2_k127_7690627_4 Lysozyme inhibitor LprI - - - 0.000005504 54.0
HFD2_k127_7704886_0 Binding-protein-dependent transport system inner membrane component - - - 1.046e-196 633.0
HFD2_k127_7704886_1 fad dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 451.0
HFD2_k127_7704886_10 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000002867 224.0
HFD2_k127_7704886_2 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 427.0
HFD2_k127_7704886_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 406.0
HFD2_k127_7704886_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008604 353.0
HFD2_k127_7704886_5 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 355.0
HFD2_k127_7704886_6 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 306.0
HFD2_k127_7704886_7 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 314.0
HFD2_k127_7704886_8 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003046 257.0
HFD2_k127_7704886_9 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002904 249.0
HFD2_k127_7708718_0 ABC transporter transmembrane region K12541 - - 1.571e-238 772.0
HFD2_k127_7708718_1 HlyD membrane-fusion protein of T1SS K12542 - - 0.0000000000000000000000000000000003433 152.0
HFD2_k127_7708718_2 TIGRFAM type I secretion outer membrane protein, TolC family K12543 - - 0.000000000000000000000000001471 123.0
HFD2_k127_7708718_3 type I secretion outer membrane protein, TolC K12543 - - 0.00000000000000000009772 97.0
HFD2_k127_7708718_4 COG0845 Membrane-fusion protein - - - 0.00000000000005886 86.0
HFD2_k127_7708718_5 hemimethylated DNA binding K11940 - - 0.000000000001046 68.0
HFD2_k127_7708718_6 TIGRFAM type I secretion outer membrane protein, TolC family K12543 - - 0.0001792 48.0
HFD2_k127_7717620_0 Belongs to the peptidase S1C family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 424.0
HFD2_k127_7717620_1 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 415.0
HFD2_k127_7717620_2 dehalogenase K21647 - 1.21.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 376.0
HFD2_k127_7717620_3 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000002912 196.0
HFD2_k127_7717620_4 transcriptional regulator - - - 0.000000000000000000000002997 113.0
HFD2_k127_773849_0 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 368.0
HFD2_k127_773849_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 312.0
HFD2_k127_7748244_0 recombinase activity - GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 561.0
HFD2_k127_7748244_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 346.0
HFD2_k127_7748244_2 - - - - 0.000000000000000000000008925 111.0
HFD2_k127_7748244_3 Carboxymuconolactone decarboxylase family - - - 0.0000000000000002266 81.0
HFD2_k127_775793_0 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 423.0
HFD2_k127_775793_1 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 411.0
HFD2_k127_7775656_0 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004656 529.0
HFD2_k127_7775656_1 - - - - 0.00000000000000000000000000000000000000000000000004895 188.0
HFD2_k127_7775656_2 Sulfurtransferase TusA K04085 - - 0.0000000006316 66.0
HFD2_k127_7801702_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005865 342.0
HFD2_k127_7801702_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 344.0
HFD2_k127_7801702_2 Cupin domain K00450 - 1.13.11.4 0.000000000003695 70.0
HFD2_k127_7823947_0 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 467.0
HFD2_k127_7823947_1 Binding-protein-dependent transport system inner membrane component K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 329.0
HFD2_k127_7823947_2 amino acid ABC transporter K02029,K09971,K10002,K10037 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 293.0
HFD2_k127_7823947_3 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000007393 121.0
HFD2_k127_7823947_4 Bacterial periplasmic substrate-binding proteins K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000006082 101.0
HFD2_k127_7823947_5 Belongs to the P(II) protein family K04752 GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007 - 0.000001456 54.0
HFD2_k127_7891891_0 Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006212 270.0
HFD2_k127_7891891_1 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000000000000000000001038 186.0
HFD2_k127_7891891_2 Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000000000000008306 156.0
HFD2_k127_7891891_3 Regulatory protein SoxS - - - 0.000000000000000000000000003478 127.0
HFD2_k127_7891891_4 Cytochrome c K08738 - - 0.000000000000000000000000004955 115.0
HFD2_k127_7894314_0 AMP-binding enzyme C-terminal domain - - - 1.068e-216 682.0
HFD2_k127_7928643_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.667e-236 735.0
HFD2_k127_7928643_1 hydrolase of the alpha beta superfamily K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004437 354.0
HFD2_k127_7928643_2 serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000006706 103.0
HFD2_k127_793892_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.401e-204 654.0
HFD2_k127_793892_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000003423 174.0
HFD2_k127_793892_2 Cell wall formation K00075 - 1.3.1.98 0.00000007907 61.0
HFD2_k127_7949294_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 480.0
HFD2_k127_7949294_1 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007023 447.0
HFD2_k127_7949294_2 Circularly permuted ATP-grasp type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 407.0
HFD2_k127_7949294_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 378.0
HFD2_k127_7949294_4 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 341.0
HFD2_k127_7949294_5 PFAM 20S proteasome A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 301.0
HFD2_k127_7949294_6 A circularly permuted ATPgrasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003809 262.0
HFD2_k127_7949294_7 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000004036 239.0
HFD2_k127_7949294_8 - - - - 0.00000000000000000000006293 106.0
HFD2_k127_795099_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000002897 220.0
HFD2_k127_795099_1 Luciferase-like monooxygenase - - - 0.000000000000000000000002427 104.0
HFD2_k127_7970896_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 479.0
HFD2_k127_7970896_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 420.0
HFD2_k127_7970896_2 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000001322 205.0
HFD2_k127_7970896_3 Cupin domain - - - 0.0000000000000000000000000000000000000000000006956 187.0
HFD2_k127_7970896_4 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0000000000000000000000000000000000002206 162.0
HFD2_k127_7970896_5 LysE type translocator K03329 - - 0.00000000000000000000000000001964 125.0
HFD2_k127_7970896_6 Glycosyl transferase 4-like - - - 0.000000000000000003107 98.0
HFD2_k127_79945_0 Protein conserved in bacteria K07793 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 594.0
HFD2_k127_79945_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 486.0
HFD2_k127_79945_2 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 412.0
HFD2_k127_79945_3 Mandelate Racemase Muconate Lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 354.0
HFD2_k127_79945_4 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000000003247 173.0
HFD2_k127_8000923_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 7.343e-269 841.0
HFD2_k127_8000923_1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000002965 119.0
HFD2_k127_8002199_0 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 420.0
HFD2_k127_8002199_1 Pfam:DUF4102 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 333.0
HFD2_k127_8002199_10 Glycosyl transferases group 1 - - - 0.0000000000000008338 83.0
HFD2_k127_8002199_11 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.000000000001593 74.0
HFD2_k127_8002199_12 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.00000000007786 71.0
HFD2_k127_8002199_13 Glycosyl transferase 4-like domain - - - 0.00008505 48.0
HFD2_k127_8002199_2 Carbamoyltransferase C-terminus K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007366 342.0
HFD2_k127_8002199_3 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 270.0
HFD2_k127_8002199_4 Acts on guanine, xanthine and to a lesser extent hypoxanthine K00769 - 2.4.2.22 0.00000000000000000000000000000000000000000000000000000000000000000004299 236.0
HFD2_k127_8002199_5 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000003383 237.0
HFD2_k127_8002199_6 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000694 228.0
HFD2_k127_8002199_7 Integrase - - - 0.00000000000000000000000000000000000000000000000000000000000006471 218.0
HFD2_k127_8002199_8 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000005088 128.0
HFD2_k127_8002199_9 Aldo/keto reductase family - - - 0.0000000000000000000000000001624 127.0
HFD2_k127_8010168_0 This protein is involved in the repair of mismatches in DNA K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 461.0
HFD2_k127_8010527_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 483.0
HFD2_k127_8010527_1 Argininosuccinate lyase C-terminal K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 442.0
HFD2_k127_8010527_2 Mannose-6-phosphate isomerase - - - 0.000002556 55.0
HFD2_k127_8027245_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 561.0
HFD2_k127_8027245_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 454.0
HFD2_k127_8027245_2 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000636 274.0
HFD2_k127_8027245_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000001971 184.0
HFD2_k127_8027245_4 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.0000000000000000000000000000000000000008693 162.0
HFD2_k127_8033891_0 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 427.0
HFD2_k127_8033891_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000009614 222.0
HFD2_k127_8033891_2 - - - - 0.00000000000000000000003035 110.0
HFD2_k127_8037307_0 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 525.0
HFD2_k127_8037307_1 COG2309 Leucyl aminopeptidase (aminopeptidase T) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 499.0
HFD2_k127_8037307_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 365.0
HFD2_k127_8037307_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003352 247.0
HFD2_k127_8037307_4 Alpha beta hydrolase K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000001108 228.0
HFD2_k127_8037307_5 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000175 194.0
HFD2_k127_8037307_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000003636 122.0
HFD2_k127_8037307_7 - - - - 0.00000000004635 68.0
HFD2_k127_8045084_0 Glutamine amidotransferase domain K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 4.439e-275 865.0
HFD2_k127_8045084_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.368e-209 658.0
HFD2_k127_8045084_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 482.0
HFD2_k127_8045084_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005973 475.0
HFD2_k127_8045084_4 PFAM Mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000002426 138.0
HFD2_k127_8047733_0 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 354.0
HFD2_k127_8047733_1 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005706 314.0
HFD2_k127_8047733_2 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000002899 61.0
HFD2_k127_8052102_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005481 467.0
HFD2_k127_8052102_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 352.0
HFD2_k127_8052102_2 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000006463 283.0
HFD2_k127_8052102_3 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000004709 209.0
HFD2_k127_8053607_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 2.358e-200 631.0
HFD2_k127_8053607_1 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.000000000000000000000000000000000000000000000002566 186.0
HFD2_k127_8053607_2 NLR family, CARD domain containing 5 - GO:0000976,GO:0000977,GO:0000978,GO:0000987,GO:0001012,GO:0001067,GO:0001817,GO:0001818,GO:0001959,GO:0001960,GO:0001961,GO:0002252,GO:0002376,GO:0002682,GO:0002683,GO:0002684,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005813,GO:0005815,GO:0005829,GO:0005856,GO:0006355,GO:0006357,GO:0006950,GO:0006952,GO:0006955,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0009617,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010647,GO:0010648,GO:0015630,GO:0019219,GO:0019220,GO:0019222,GO:0023051,GO:0023056,GO:0023057,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031347,GO:0031348,GO:0031349,GO:0032088,GO:0032479,GO:0032480,GO:0042325,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043433,GO:0043549,GO:0043565,GO:0044092,GO:0044212,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0045343,GO:0045345,GO:0045824,GO:0045893,GO:0045935,GO:0045944,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051173,GO:0051174,GO:0051239,GO:0051241,GO:0051252,GO:0051254,GO:0051338,GO:0051607,GO:0051704,GO:0051707,GO:0060255,GO:0060330,GO:0060332,GO:0060334,GO:0060335,GO:0060338,GO:0060339,GO:0060340,GO:0060759,GO:0060760,GO:0060761,GO:0065007,GO:0065009,GO:0080090,GO:0080134,GO:0097159,GO:0098542,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000001615 63.0
HFD2_k127_8058126_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 2.332e-194 613.0
HFD2_k127_8058126_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006375 556.0
HFD2_k127_8058126_2 dioxygenase, alpha - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 539.0
HFD2_k127_8058126_3 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 506.0
HFD2_k127_8058126_4 Beta subunit - - - 0.0000000000000000000000000000000000005556 160.0
HFD2_k127_8058126_5 PAS domain - - - 0.00000000002686 72.0
HFD2_k127_8059120_0 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04099 - 1.13.11.57 1.345e-207 652.0
HFD2_k127_8059120_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000001932 92.0
HFD2_k127_8086028_0 Thiamine pyrophosphate enzyme, central domain K01577 - 4.1.1.8 0.0 1022.0
HFD2_k127_8086028_1 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 7.221e-250 774.0
HFD2_k127_8086028_2 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 577.0
HFD2_k127_8086028_3 protein conserved in bacteria K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 452.0
HFD2_k127_8086028_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 451.0
HFD2_k127_8086028_5 Regulatory protein GntR HTH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 346.0
HFD2_k127_8086028_6 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 319.0
HFD2_k127_8086028_7 serine threonine protein kinase K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002126 279.0
HFD2_k127_8086028_8 Domain of unknown function (DUF4189) - - - 0.000000000000001337 81.0
HFD2_k127_8086357_0 4-hydroxyphenylacetate 3-hydroxylase K14534 - 4.2.1.120,5.3.3.3 1.588e-219 693.0
HFD2_k127_8086357_1 PFAM AMP-dependent synthetase and ligase K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 346.0
HFD2_k127_8086357_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 336.0
HFD2_k127_8086357_3 PIN domain K07062 - - 0.00000000000000000000000000000000000000000006339 164.0
HFD2_k127_8086357_4 LysE type translocator - - - 0.0000000000000000000000000000000000000000002577 165.0
HFD2_k127_8086357_5 Plasmid stability protein K21495 - - 0.00000000000000000007515 91.0
HFD2_k127_8086357_6 Acetyltransferase (GNAT) family - - - 0.00000000003473 63.0
HFD2_k127_8086357_7 PFAM Tetratricopeptide repeat - - - 0.000000001873 66.0
HFD2_k127_8090060_0 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009979 392.0
HFD2_k127_8090060_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 338.0
HFD2_k127_8106504_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 477.0
HFD2_k127_8106504_1 transcriptional regulator, araC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 467.0
HFD2_k127_8106504_2 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 459.0
HFD2_k127_8106504_3 methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 368.0
HFD2_k127_8106504_4 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 334.0
HFD2_k127_8106504_5 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 342.0
HFD2_k127_8106504_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001088 241.0
HFD2_k127_8106504_7 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000006179 199.0
HFD2_k127_8106504_8 Cytochrome oxidase maturation protein - - - 0.000000000005427 78.0
HFD2_k127_8106504_9 PrpF protein K16514 - 5.3.2.8 0.000005206 49.0
HFD2_k127_8119245_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 4.751e-207 660.0
HFD2_k127_8119245_1 o-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002612 257.0
HFD2_k127_8119245_2 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000002582 224.0
HFD2_k127_812051_0 Belongs to the 5'-nucleotidase family K01081,K11751 - 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 472.0
HFD2_k127_812051_1 acetyltransferase K03829 - - 0.0000000000000000000000000000000000000000000000000008208 189.0
HFD2_k127_8124465_0 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 385.0
HFD2_k127_8124465_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 361.0
HFD2_k127_8124465_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002827 271.0
HFD2_k127_8124465_3 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001338 256.0
HFD2_k127_8124465_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000002617 112.0
HFD2_k127_8124465_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000006187 103.0
HFD2_k127_8124465_6 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000005462 73.0
HFD2_k127_8126025_0 chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 498.0
HFD2_k127_8149212_0 of ABC transporters with duplicated ATPase K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 434.0
HFD2_k127_8149212_1 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 412.0
HFD2_k127_8149212_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000355 135.0
HFD2_k127_8163423_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 485.0
HFD2_k127_8163423_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 450.0
HFD2_k127_8163423_2 Squalene/phytoene synthase K21678,K21679 - 2.5.1.103,4.2.3.156 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 297.0
HFD2_k127_8166631_0 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000004694 152.0
HFD2_k127_8166631_1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity K01724 GO:0000003,GO:0003006,GO:0003674,GO:0003712,GO:0003713,GO:0003824,GO:0004497,GO:0004505,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0007049,GO:0008124,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009653,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019219,GO:0019222,GO:0019439,GO:0019752,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030435,GO:0030437,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031974,GO:0031981,GO:0032502,GO:0032505,GO:0034293,GO:0042737,GO:0042763,GO:0042764,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043436,GO:0043496,GO:0043933,GO:0043934,GO:0043935,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045893,GO:0045935,GO:0046395,GO:0048468,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051098,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0051321,GO:0051704,GO:0055114,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0140110,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222,GO:1902680,GO:1903046,GO:1903506,GO:1903508,GO:2000112,GO:2001141 4.2.1.96 0.000000000000000000000000000000002232 135.0
HFD2_k127_8166631_2 Domain of unknown function (DUF1877) - - - 0.0000000000000000000000009107 111.0
HFD2_k127_8166631_3 AAA domain - - - 0.00000000000000000002071 92.0
HFD2_k127_8166631_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000001182 70.0
HFD2_k127_8166631_5 Sel1-like repeats. K07126 - - 0.0006535 49.0
HFD2_k127_8171549_0 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 547.0
HFD2_k127_8171549_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 312.0
HFD2_k127_8171549_2 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007402 284.0
HFD2_k127_8171549_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000001216 139.0
HFD2_k127_8171549_4 - - - - 0.00000000000000000000000000000001154 143.0
HFD2_k127_8171549_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000181 81.0
HFD2_k127_8175553_0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 330.0
HFD2_k127_8175553_1 protein conserved in bacteria K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 295.0
HFD2_k127_8175553_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000003971 263.0
HFD2_k127_8175553_3 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000009436 207.0
HFD2_k127_8175553_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000000000214 104.0
HFD2_k127_8175553_5 COG2825 Outer membrane protein - - - 0.00000000006987 71.0
HFD2_k127_817903_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 515.0
HFD2_k127_817903_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000004659 145.0
HFD2_k127_817903_2 - - - - 0.0000000000000000000000000000001155 134.0
HFD2_k127_8186631_0 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 374.0
HFD2_k127_8186631_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 341.0
HFD2_k127_8186631_2 Bacterial periplasmic substrate-binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 344.0
HFD2_k127_8186631_3 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000004673 239.0
HFD2_k127_820411_0 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 528.0
HFD2_k127_820411_1 Phosphoenolpyruvate phosphomutase K01841,K03417 - 4.1.3.30,5.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 373.0
HFD2_k127_820411_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000004217 199.0
HFD2_k127_820411_3 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000131 187.0
HFD2_k127_820411_4 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000007361 160.0
HFD2_k127_820411_5 PAS domain - - - 0.0000000000000000005554 94.0
HFD2_k127_8205177_0 belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 337.0
HFD2_k127_8205177_1 Putative DNA-binding domain - - - 0.000000000000000000000000000000157 135.0
HFD2_k127_8205177_2 DoxX K15977 - - 0.00000000000000000002124 102.0
HFD2_k127_8205177_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000165 64.0
HFD2_k127_8205177_4 Predicted integral membrane protein (DUF2282) - - - 0.000000006102 62.0
HFD2_k127_8231799_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 569.0
HFD2_k127_8231799_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 554.0
HFD2_k127_8231799_2 DNA polymerase III beta subunit K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 522.0
HFD2_k127_8231799_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 396.0
HFD2_k127_8231799_4 SMART Rhodanese domain protein - - - 0.000000000005682 65.0
HFD2_k127_8242750_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 375.0
HFD2_k127_8242750_1 OpgC protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007009 260.0
HFD2_k127_8242750_2 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000006441 180.0
HFD2_k127_8256687_0 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 429.0
HFD2_k127_8256687_1 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 349.0
HFD2_k127_8258803_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 349.0
HFD2_k127_8258803_1 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.0000000000000000000000000000000000000000000001833 173.0
HFD2_k127_8258803_2 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.00000000001327 76.0
HFD2_k127_8258803_3 Transcriptional regulator - - - 0.0000000001368 63.0
HFD2_k127_8258803_4 Acyl-CoA dehydrogenase N terminal K20035 - - 0.00000009838 55.0
HFD2_k127_8270207_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.239e-233 735.0
HFD2_k127_8288827_0 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 459.0
HFD2_k127_8288827_1 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01760 - 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 439.0
HFD2_k127_8288827_2 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 379.0
HFD2_k127_8288827_3 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 368.0
HFD2_k127_8288827_4 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 295.0
HFD2_k127_8288827_5 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000002318 183.0
HFD2_k127_8288827_6 SET domain K07117 - - 0.000000000000000000000000000001449 125.0
HFD2_k127_8288827_7 - - - - 0.0000003604 57.0
HFD2_k127_8288827_8 ATPases associated with a variety of cellular activities K02028,K02029,K09972 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 0.000001086 50.0
HFD2_k127_8317760_0 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 371.0
HFD2_k127_8317760_1 Reductase C-terminal K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000009677 204.0
HFD2_k127_8317760_2 - - - - 0.00000000000000000000000000000000000000000000000002455 186.0
HFD2_k127_8321106_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1506.0
HFD2_k127_8321106_1 Glutathione-dependent formaldehyde-activating, GFA - - - 0.000000000000000000000000000000000000000000000000000000000001343 212.0
HFD2_k127_8321106_2 SCP-like extracellular protein. Source PGD - - - 0.00007186 53.0
HFD2_k127_8321106_3 Protein of unknown function (DUF2934) - - - 0.0005459 48.0
HFD2_k127_8324903_0 Transport of potassium into the cell K03549 - - 2.915e-206 659.0
HFD2_k127_8324903_1 Belongs to the UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 502.0
HFD2_k127_8324903_2 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000009906 240.0
HFD2_k127_8324903_3 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.000000000000000000000000000000000000000000000000000000002542 207.0
HFD2_k127_8324903_4 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000000000000000000007343 171.0
HFD2_k127_8324903_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.000000000000000000000000000000000000000000005912 183.0
HFD2_k127_8324903_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000004042 156.0
HFD2_k127_8324903_7 transcriptional regulator - - - 0.000000000000000000000000000000000000007217 164.0
HFD2_k127_8324903_8 response to abiotic stimulus K06867 - - 0.00000234 50.0
HFD2_k127_8324903_9 Endonuclease containing a URI domain K07461 - - 0.0001212 48.0
HFD2_k127_8325687_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.0 1069.0
HFD2_k127_8325687_1 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 534.0
HFD2_k127_8325687_2 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 466.0
HFD2_k127_8325687_3 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 323.0
HFD2_k127_8325687_4 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 257.0
HFD2_k127_8325687_5 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.000000000000000000000000000000000000000000000000000000001455 204.0
HFD2_k127_8325687_6 XdhC and CoxI family - - - 0.00000000000000000000000000000000000002995 161.0
HFD2_k127_8325687_7 Protein of unknown function (DUF992) - - - 0.0000000000000000000000000000000003789 137.0
HFD2_k127_8325687_8 Domain of unknown function (DUF4189) - - - 0.000000000001 74.0
HFD2_k127_8325687_9 lipolytic protein G-D-S-L family - - - 0.00000000001254 71.0
HFD2_k127_8354008_0 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 393.0
HFD2_k127_8354008_1 Scavenger mRNA decapping enzyme C-term binding - - - 0.0000000000000000000000000000000000000000000000000005016 186.0
HFD2_k127_8354008_2 SNARE associated Golgi protein - - - 0.0000000000000001794 83.0
HFD2_k127_8403621_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 523.0
HFD2_k127_8403621_1 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 396.0
HFD2_k127_8403621_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 366.0
HFD2_k127_8403621_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000959 297.0
HFD2_k127_8403621_4 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000004462 182.0
HFD2_k127_8403621_5 - - - - 0.00000000000001357 84.0
HFD2_k127_8408829_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 398.0
HFD2_k127_8408829_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004993 300.0
HFD2_k127_8408829_2 Protein of unknown function (DUF2817) - - - 0.000000000000008051 76.0
HFD2_k127_8434474_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1152.0
HFD2_k127_8434474_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 609.0
HFD2_k127_8434474_10 Sel1-like repeats. K07126 - - 0.000000000000000001403 100.0
HFD2_k127_8434474_2 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007082 323.0
HFD2_k127_8434474_3 Branched-chain amino acid ABC transporter substrate-binding protein K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 320.0
HFD2_k127_8434474_4 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 317.0
HFD2_k127_8434474_5 Branched-chain amino acid transport system / permease component K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003073 298.0
HFD2_k127_8434474_6 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000006951 242.0
HFD2_k127_8434474_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000558 162.0
HFD2_k127_8434474_8 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000001432 115.0
HFD2_k127_8434474_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000005153 104.0
HFD2_k127_84563_0 PFAM AMP-dependent synthetase and ligase K04110 - 6.2.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 441.0
HFD2_k127_84563_1 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 321.0
HFD2_k127_8464239_0 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 289.0
HFD2_k127_8464239_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005998 236.0
HFD2_k127_8464239_2 protein conserved in bacteria - - - 0.00000000000000000000001388 105.0
HFD2_k127_8464239_3 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0000000000000221 74.0
HFD2_k127_8464239_4 Activator of Hsp90 ATPase - - - 0.00006735 46.0
HFD2_k127_8471819_0 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 409.0
HFD2_k127_8471819_1 NADPH:quinone reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001285 250.0
HFD2_k127_8471819_2 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000005044 246.0
HFD2_k127_8498116_0 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000166 187.0
HFD2_k127_8498116_1 - - - - 0.00000000000000000000000000000002241 128.0
HFD2_k127_8498116_2 - - - - 0.0000000000000000000000000000006373 132.0
HFD2_k127_8499574_0 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002585 256.0
HFD2_k127_8499574_1 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000324 128.0
HFD2_k127_8516752_0 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001275 285.0
HFD2_k127_8516752_1 Cytochrome c, class I K08738 - - 0.0000000000000000000000000000000000000000001263 169.0
HFD2_k127_8516752_2 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.0000000000000000000000000001579 123.0
HFD2_k127_8526753_0 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 305.0
HFD2_k127_8526753_1 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000001895 237.0
HFD2_k127_8526753_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000005093 229.0
HFD2_k127_8526753_3 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000001131 231.0
HFD2_k127_8526753_4 Disulfide bond formation protein DsbB K03611 - - 0.000000000000000000000000000000000009511 143.0
HFD2_k127_8526753_5 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000002211 96.0
HFD2_k127_8526753_6 Cytochrome c - - - 0.0000000000000001418 83.0
HFD2_k127_8526753_7 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000002477 70.0
HFD2_k127_854480_0 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 434.0
HFD2_k127_854480_1 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 417.0
HFD2_k127_854480_2 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit - - - 0.000000000000000000000000000000000000000000000002555 192.0
HFD2_k127_854480_3 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 0.0000000000000000000000000005464 123.0
HFD2_k127_856383_0 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 360.0
HFD2_k127_856383_1 - - - - 0.000000002612 70.0
HFD2_k127_8581198_0 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 385.0
HFD2_k127_8581198_1 COG2030 Acyl dehydratase K14449 - 4.2.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 365.0
HFD2_k127_8581198_2 Phosphomethylpyrimidine kinase K00868 - 2.7.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000001943 248.0
HFD2_k127_8581198_3 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000004133 240.0
HFD2_k127_8581198_4 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000006875 82.0
HFD2_k127_8654382_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002773 260.0
HFD2_k127_8654382_1 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001628 236.0
HFD2_k127_8654382_2 2'-5' RNA ligase superfamily - - - 0.000000000000000000000000000000005962 134.0
HFD2_k127_8654382_3 Tripartite ATP-independent periplasmic transporter, DctM component - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000002491 125.0
HFD2_k127_8654382_4 Protein of unknown function (DUF1153) - - - 0.0000000000001015 77.0
HFD2_k127_8654382_5 sequence-specific DNA binding K07726 - - 0.000000006944 59.0
HFD2_k127_8663682_0 ATPases associated with a variety of cellular activities K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 355.0
HFD2_k127_8663682_1 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 334.0
HFD2_k127_8663682_2 transport system auxiliary component K18480 - - 0.000000000000000000000000000000000000000000000000006351 190.0
HFD2_k127_8663682_3 MlaD protein K02067,K06192 - - 0.0000000000000000000000000000000000000000000001936 179.0
HFD2_k127_869666_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 539.0
HFD2_k127_869666_1 Response regulator receiver - - - 0.000000000000000000000000000000000000000000003611 169.0
HFD2_k127_8705140_0 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001701 282.0
HFD2_k127_8705140_1 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000002351 175.0
HFD2_k127_8719387_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 5.161e-236 740.0
HFD2_k127_893528_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 499.0
HFD2_k127_903692_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.794e-294 912.0
HFD2_k127_903692_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000001409 207.0
HFD2_k127_903692_2 Protein of unknown function (DUF1348) - - - 0.00000008388 60.0
HFD2_k127_903692_3 - - - - 0.0006314 45.0
HFD2_k127_906180_0 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 473.0
HFD2_k127_906180_1 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 403.0
HFD2_k127_906180_2 Putative FMN-binding domain K07734 - - 0.000000000000000000000000000000000000000000000000000163 189.0
HFD2_k127_906906_0 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K15555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002549 267.0
HFD2_k127_906906_1 Binding-protein-dependent transport system inner membrane component K15599 - - 0.0000000000000000000000000000000000000000000000000000002812 214.0
HFD2_k127_906906_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0000000000000000000000000006703 113.0
HFD2_k127_906906_3 NMT1/THI5 like K02051 - - 0.000000000000004783 87.0
HFD2_k127_906906_4 Amidohydrolase family - - - 0.000000000000143 79.0
HFD2_k127_912656_0 Protein conserved in bacteria K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008343 384.0
HFD2_k127_912656_1 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000969 176.0
HFD2_k127_912656_2 - - - - 0.00000000000000000000000000000000000000000005283 162.0
HFD2_k127_912656_3 - - - - 0.0000000000000000000000000009093 119.0
HFD2_k127_912656_4 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000123 88.0
HFD2_k127_917427_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 364.0
HFD2_k127_917427_1 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000123 111.0
HFD2_k127_922696_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 3.956e-241 752.0
HFD2_k127_922696_1 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 2.441e-228 751.0
HFD2_k127_922696_2 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 539.0
HFD2_k127_922696_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000006534 197.0
HFD2_k127_922696_4 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000005164 173.0
HFD2_k127_922696_5 TIGRFAM TRAP transporter, DctM subunit - - - 0.000000000000000000000000000000000000015 148.0
HFD2_k127_922696_6 Amidohydrolase family - - - 0.00000000006654 66.0
HFD2_k127_92582_0 AMP-binding enzyme C-terminal domain K00666,K16876 - 6.2.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000004369 261.0
HFD2_k127_92582_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.000000000000000000000000000000000001056 140.0
HFD2_k127_92582_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.000000002131 61.0
HFD2_k127_930738_0 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 509.0
HFD2_k127_930738_1 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 289.0
HFD2_k127_930738_2 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000001003 245.0
HFD2_k127_930738_3 Thiol disulfide interchange protein K04084,K08344 - 1.8.1.8 0.0000000000000000000000000000000000000000003053 171.0
HFD2_k127_930738_4 - - - - 0.0000005364 61.0
HFD2_k127_93198_0 Glycine cleavage system T protein K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 458.0
HFD2_k127_93198_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000003951 210.0
HFD2_k127_93198_2 AraC-binding-like domain - - - 0.000000000000000000000000000000000000000000000001425 187.0
HFD2_k127_93198_3 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.000000000000000000000000000000000000000000006053 168.0
HFD2_k127_93198_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000002381 158.0
HFD2_k127_93198_5 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000001521 138.0
HFD2_k127_93198_6 Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000000000006095 120.0
HFD2_k127_93198_7 - - - - 0.0000000000000002687 86.0
HFD2_k127_93198_8 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000177 59.0
HFD2_k127_93215_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 577.0
HFD2_k127_93215_1 FAD binding domain K00480,K22270 - 1.14.13.1,1.14.13.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 505.0
HFD2_k127_93215_2 TRAP transporter solute receptor TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 415.0
HFD2_k127_93215_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 346.0
HFD2_k127_93215_4 Domain of unknown function (DUF3394) - - - 0.000000000000000000000000000000000003111 143.0
HFD2_k127_93513_0 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 343.0
HFD2_k127_93513_1 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 316.0
HFD2_k127_93513_2 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 289.0
HFD2_k127_93513_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000009342 63.0
HFD2_k127_94899_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 418.0
HFD2_k127_951240_0 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 343.0
HFD2_k127_951240_1 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.0000000000000000000000000000000000000000000000000000000000001547 221.0
HFD2_k127_951240_2 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.0000000000000000000000000000000000000000000000000000001155 203.0
HFD2_k127_951240_3 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 0.000000000002038 66.0
HFD2_k127_951240_4 Aldolase/RraA - - - 0.00000003729 57.0
HFD2_k127_958392_0 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 4.107e-210 677.0
HFD2_k127_958392_1 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000000000000000002822 128.0
HFD2_k127_977314_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 3.173e-244 768.0
HFD2_k127_977314_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 420.0
HFD2_k127_977314_2 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 351.0
HFD2_k127_977314_3 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000000000000000000000005605 167.0
HFD2_k127_980871_0 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 371.0
HFD2_k127_980871_1 ornithine cyclodeaminase mu-crystallin K19244 - 1.4.1.1 0.000000000000000000000000000000000000000002857 171.0
HFD2_k127_980871_2 ABC-type Fe3 transport system permease component K02011 - - 0.0000000000000000000000003347 113.0
HFD2_k127_980871_3 Bacterial extracellular solute-binding protein - - - 0.0000000000104 74.0
HFD2_k127_980871_4 Bacterial extracellular solute-binding protein K02012 - - 0.000001625 53.0
HFD2_k127_986480_0 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008585 417.0
HFD2_k127_986480_1 4,5-dihydroxyphthalate decarboxylase K04102 - 4.1.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 332.0
HFD2_k127_986480_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001546 271.0
HFD2_k127_990332_0 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000001328 258.0
HFD2_k127_990332_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000004108 246.0
HFD2_k127_990332_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000002696 128.0
HFD2_k127_99242_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006853 465.0
HFD2_k127_99242_1 alcohol dehydrogenase K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008076 448.0
HFD2_k127_99242_2 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 378.0
HFD2_k127_99242_3 synthase K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 358.0
HFD2_k127_99242_4 Uncharacterised BCR, YnfA/UPF0060 family K09771 - - 0.00000000000000000000000000000000000000000000004812 171.0
HFD2_k127_99242_5 PFAM Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA FabZ K02372 - 4.2.1.59 0.00000000000000000000000000000000002117 146.0
HFD2_k127_99242_6 acyl carrier protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000202 134.0
HFD2_k127_99242_7 Peptidase family M48 - - - 0.0000000000008865 73.0
HFD2_k127_99242_8 - - - - 0.0001627 51.0