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Overview

ID MAG01661
Name HFD2_bin.53
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order UBA5066
Family Gp7-AA6
Genus Gp7-AA6
Species
Assembly information
Completeness (%) 86.02
Contamination (%) 1.79
GC content (%) 67.0
N50 (bp) 23,259
Genome size (bp) 3,407,686

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2898

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1048117_0 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005685 539.0
HFD2_k127_1048117_1 Lipase maturation factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 353.0
HFD2_k127_1048117_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000006751 76.0
HFD2_k127_1048117_11 BON domain - - - 0.0000000813 59.0
HFD2_k127_1048117_12 Tetratricopeptide repeat - - - 0.00001038 59.0
HFD2_k127_1048117_13 Protein tyrosine kinase K12132 - 2.7.11.1 0.00001368 59.0
HFD2_k127_1048117_2 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000008516 267.0
HFD2_k127_1048117_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000001184 252.0
HFD2_k127_1048117_4 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000003679 207.0
HFD2_k127_1048117_5 - - - - 0.0000000000000000000000000000000000000000000000006161 200.0
HFD2_k127_1048117_6 Penicillinase repressor - - - 0.0000000000000000000000000000000000000001031 155.0
HFD2_k127_1048117_7 DNA mismatch repair protein MutT K01515 - 3.6.1.13 0.00000000000000000000000000000000001841 141.0
HFD2_k127_1048117_8 Cytochrome P450 - - - 0.00000000000000000000672 94.0
HFD2_k127_1048117_9 collagen metabolic process - - - 0.0000000000000000006857 95.0
HFD2_k127_1063543_0 Involved in the tonB-independent uptake of proteins - - - 3.864e-228 734.0
HFD2_k127_1063543_1 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003845 621.0
HFD2_k127_1063543_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 575.0
HFD2_k127_1063543_3 Protein of unknown function (DUF971) K03593 - - 0.00000000000000000000007265 110.0
HFD2_k127_1078426_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1440.0
HFD2_k127_1078426_1 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0 1311.0
HFD2_k127_1078426_10 NAD-dependent epimerase dehydratase K01784,K12454 - 5.1.3.10,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007428 391.0
HFD2_k127_1078426_11 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 398.0
HFD2_k127_1078426_12 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 376.0
HFD2_k127_1078426_13 PhoH-like protein K06217 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 364.0
HFD2_k127_1078426_14 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 372.0
HFD2_k127_1078426_15 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 378.0
HFD2_k127_1078426_16 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 379.0
HFD2_k127_1078426_17 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 326.0
HFD2_k127_1078426_18 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 312.0
HFD2_k127_1078426_19 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003246 287.0
HFD2_k127_1078426_2 PFAM UvrD REP helicase K03657 - 3.6.4.12 2.713e-208 669.0
HFD2_k127_1078426_20 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003292 281.0
HFD2_k127_1078426_21 Glycosyl transferase, family 2 K00721,K20534 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000001708 262.0
HFD2_k127_1078426_22 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000619 258.0
HFD2_k127_1078426_23 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000003551 244.0
HFD2_k127_1078426_24 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000007875 248.0
HFD2_k127_1078426_25 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002923 247.0
HFD2_k127_1078426_26 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000003269 233.0
HFD2_k127_1078426_27 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000005645 241.0
HFD2_k127_1078426_28 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000002874 218.0
HFD2_k127_1078426_29 Transporter associated domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000003831 226.0
HFD2_k127_1078426_3 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 558.0
HFD2_k127_1078426_30 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000004783 223.0
HFD2_k127_1078426_31 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000005007 209.0
HFD2_k127_1078426_32 GAF domain - - - 0.000000000000000000000000000000000000000000000002185 198.0
HFD2_k127_1078426_33 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000006099 186.0
HFD2_k127_1078426_34 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000209 178.0
HFD2_k127_1078426_35 methyltransferase - - - 0.000000000000000000000000000000000000000002741 177.0
HFD2_k127_1078426_36 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000003006 119.0
HFD2_k127_1078426_37 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000006964 111.0
HFD2_k127_1078426_38 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000822 109.0
HFD2_k127_1078426_39 Belongs to the universal stress protein A family - - - 0.000000000000000000007388 103.0
HFD2_k127_1078426_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03918 - 2.6.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 492.0
HFD2_k127_1078426_40 endoglucanase-related protein, glucosyl hydrolase family 9 protein - - - 0.0000000000004392 80.0
HFD2_k127_1078426_41 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.00000000000524 79.0
HFD2_k127_1078426_42 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000007659 72.0
HFD2_k127_1078426_43 O-Antigen ligase - - - 0.000000005082 70.0
HFD2_k127_1078426_44 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000002204 61.0
HFD2_k127_1078426_45 guanosine tetraphosphate metabolic process K07816 - 2.7.6.5 0.000007003 58.0
HFD2_k127_1078426_5 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 481.0
HFD2_k127_1078426_6 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 441.0
HFD2_k127_1078426_7 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 432.0
HFD2_k127_1078426_8 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 433.0
HFD2_k127_1078426_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 421.0
HFD2_k127_1084900_0 PFAM Type II secretion system protein E K02652 - - 3.099e-214 679.0
HFD2_k127_1084900_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 1.174e-210 671.0
HFD2_k127_1084900_10 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000004204 187.0
HFD2_k127_1084900_11 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000114 175.0
HFD2_k127_1084900_12 PFAM glycosyl transferase family 9 K02841 - - 0.0000000000000000000000000000000000000000244 166.0
HFD2_k127_1084900_13 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000005261 115.0
HFD2_k127_1084900_14 Protein of unknown function (DUF3108) - - - 0.0000000000000000000002593 112.0
HFD2_k127_1084900_15 Pilus assembly protein K02662 - - 0.000000000001157 80.0
HFD2_k127_1084900_16 PFAM Fimbrial assembly family protein K02663 - - 0.0000000000453 72.0
HFD2_k127_1084900_17 Pilus assembly protein, PilO K02664 - - 0.000001267 59.0
HFD2_k127_1084900_18 general secretion pathway protein D K02453 - - 0.000009778 56.0
HFD2_k127_1084900_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 332.0
HFD2_k127_1084900_3 Type ii and iii secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 316.0
HFD2_k127_1084900_4 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000195 284.0
HFD2_k127_1084900_5 Phosphomethylpyrimidine kinase K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000008498 267.0
HFD2_k127_1084900_6 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000003322 260.0
HFD2_k127_1084900_7 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000002535 239.0
HFD2_k127_1084900_8 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000004983 224.0
HFD2_k127_1084900_9 D,D-heptose 1,7-bisphosphate phosphatase K02841,K02843,K02849,K03271,K03272,K03273 - 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 0.0000000000000000000000000000000000000000000000000000004015 207.0
HFD2_k127_1100599_0 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 390.0
HFD2_k127_1100599_1 - - - - 0.00000000000000000000000000000000000002089 163.0
HFD2_k127_1100599_2 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000212 131.0
HFD2_k127_1100599_3 ABC transporter K06158 - - 0.000000000000000000000000000343 119.0
HFD2_k127_1100599_4 - - - - 0.00006303 55.0
HFD2_k127_1114044_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 4.009e-292 913.0
HFD2_k127_1114044_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 595.0
HFD2_k127_1114044_10 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005015 335.0
HFD2_k127_1114044_11 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 327.0
HFD2_k127_1114044_12 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 316.0
HFD2_k127_1114044_13 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 308.0
HFD2_k127_1114044_14 ABC-2 type transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 296.0
HFD2_k127_1114044_15 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001946 300.0
HFD2_k127_1114044_16 ABC transporter, permease protein K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005619 267.0
HFD2_k127_1114044_17 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000004834 271.0
HFD2_k127_1114044_18 ThiF family K03148,K21029 - 2.7.7.73,2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000002745 257.0
HFD2_k127_1114044_19 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000001504 254.0
HFD2_k127_1114044_2 DNA polymerase K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 489.0
HFD2_k127_1114044_20 MotA TolQ ExbB proton channel K03561,K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000001776 234.0
HFD2_k127_1114044_21 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000002525 246.0
HFD2_k127_1114044_22 maltose O-acetyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000003747 231.0
HFD2_k127_1114044_23 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000004102 236.0
HFD2_k127_1114044_24 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000001189 228.0
HFD2_k127_1114044_25 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000001614 185.0
HFD2_k127_1114044_26 SMART phosphoesterase PHP domain protein K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000004413 190.0
HFD2_k127_1114044_27 Riboflavin synthase K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000001382 172.0
HFD2_k127_1114044_28 PFAM secretion protein HlyD family protein K01993 - - 0.000000000000000000000000000000000000000000931 175.0
HFD2_k127_1114044_29 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000000000000000000003912 158.0
HFD2_k127_1114044_3 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 433.0
HFD2_k127_1114044_30 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000005034 140.0
HFD2_k127_1114044_31 protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000006124 124.0
HFD2_k127_1114044_32 oxidoreductase activity - - - 0.000000000000000000000000004955 127.0
HFD2_k127_1114044_33 Biopolymer transport protein K03559,K03560 - - 0.0000000000000000000000006123 110.0
HFD2_k127_1114044_34 Tetratricopeptide repeat - - - 0.0000000000000000000000334 113.0
HFD2_k127_1114044_35 Glutathione peroxidase - - - 0.000000000000000000001062 104.0
HFD2_k127_1114044_36 biopolymer transport protein K03559,K03560 - - 0.000000000000000000001502 99.0
HFD2_k127_1114044_37 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000001577 98.0
HFD2_k127_1114044_38 ATPase or kinase K06925 - - 0.00000000000000007105 95.0
HFD2_k127_1114044_39 polysaccharide deacetylase - - - 0.00000000000005278 86.0
HFD2_k127_1114044_4 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 421.0
HFD2_k127_1114044_40 gtp cyclohydrolase K01495 - 3.5.4.16 0.00000000028 65.0
HFD2_k127_1114044_41 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000954 72.0
HFD2_k127_1114044_42 transcriptional regulator - - - 0.00000000241 71.0
HFD2_k127_1114044_43 Belongs to the ompA family K03286 - - 0.00000002345 64.0
HFD2_k127_1114044_44 Sortase family K07284 - 3.4.22.70 0.000001626 59.0
HFD2_k127_1114044_45 regulation of canonical Wnt signaling pathway involved in osteoblast differentiation - - - 0.000003662 56.0
HFD2_k127_1114044_5 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 355.0
HFD2_k127_1114044_6 ABC-type multidrug transport system ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 347.0
HFD2_k127_1114044_7 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 344.0
HFD2_k127_1114044_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 353.0
HFD2_k127_1114044_9 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 354.0
HFD2_k127_1226307_0 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 605.0
HFD2_k127_1226307_1 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 602.0
HFD2_k127_1226307_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000004063 119.0
HFD2_k127_1226307_11 electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05580 - 1.6.5.3 0.000000000000000000000000007647 115.0
HFD2_k127_1226307_12 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000005274 112.0
HFD2_k127_1226307_13 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0004623 46.0
HFD2_k127_1226307_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 475.0
HFD2_k127_1226307_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 370.0
HFD2_k127_1226307_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 328.0
HFD2_k127_1226307_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000007802 242.0
HFD2_k127_1226307_6 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000487 206.0
HFD2_k127_1226307_7 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000001062 202.0
HFD2_k127_1226307_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000001143 152.0
HFD2_k127_1226307_9 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.000000000000000000000000000001427 124.0
HFD2_k127_1327047_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1330.0
HFD2_k127_1327047_1 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 356.0
HFD2_k127_1327047_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000009142 138.0
HFD2_k127_1327047_11 amine dehydrogenase activity K21449 - - 0.00000000000000000000000008112 114.0
HFD2_k127_1327047_12 Thioredoxin-like - - - 0.0000000000000000000000836 111.0
HFD2_k127_1327047_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000008461 85.0
HFD2_k127_1327047_2 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 335.0
HFD2_k127_1327047_3 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004468 256.0
HFD2_k127_1327047_4 metallochaperone-like domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000001109 253.0
HFD2_k127_1327047_5 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000002082 254.0
HFD2_k127_1327047_6 Protein of unknown function (DUF2400) - - - 0.000000000000000000000000000000000000000000000000000000000002234 219.0
HFD2_k127_1327047_7 Belongs to the FPG family K05522,K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000001019 226.0
HFD2_k127_1327047_8 MobA-Related Protein K07141 - 2.7.7.76 0.00000000000000000000000000000000000000000000000003945 186.0
HFD2_k127_1327047_9 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.00000000000000000000000000000000000001542 153.0
HFD2_k127_1340200_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 5.046e-209 673.0
HFD2_k127_1340200_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 385.0
HFD2_k127_1340200_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 348.0
HFD2_k127_1340200_3 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000001061 209.0
HFD2_k127_1340200_4 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000001254 182.0
HFD2_k127_1340200_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000006916 143.0
HFD2_k127_1340200_6 Methyltransferase domain - - - 0.000000000000000000000000000000006274 141.0
HFD2_k127_1340200_7 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000006679 89.0
HFD2_k127_136721_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 1437.0
HFD2_k127_136721_1 CoA binding domain K01905,K22224 - 6.2.1.13 1.228e-203 655.0
HFD2_k127_136721_2 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000005172 241.0
HFD2_k127_136721_3 - K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000241 224.0
HFD2_k127_136721_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000008296 169.0
HFD2_k127_136721_5 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000000000000000000000001136 164.0
HFD2_k127_1388766_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 3.503e-207 696.0
HFD2_k127_1388766_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 515.0
HFD2_k127_1388766_10 RmlD substrate binding domain K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000001575 227.0
HFD2_k127_1388766_11 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774,K22110 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 - 0.0000000000000000000000000000000000000000000000000000000001597 229.0
HFD2_k127_1388766_12 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000003663 218.0
HFD2_k127_1388766_13 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000002036 145.0
HFD2_k127_1388766_14 membrane - - - 0.00000000000000000000000004585 122.0
HFD2_k127_1388766_15 DSBA-like thioredoxin domain - - - 0.000000000000000000005182 106.0
HFD2_k127_1388766_16 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000001292 94.0
HFD2_k127_1388766_17 carboxylase K01968 - 6.4.1.4 0.0000000000001582 84.0
HFD2_k127_1388766_18 UbiA prenyltransferase family K04040 - 2.5.1.133,2.5.1.62 0.00000000000251 78.0
HFD2_k127_1388766_19 chaperone-mediated protein folding - - - 0.000000000003442 78.0
HFD2_k127_1388766_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 466.0
HFD2_k127_1388766_20 modulator of DNA gyrase K03568 - - 0.0000000003849 72.0
HFD2_k127_1388766_21 Modulator of DNA gyrase K03568 - - 0.00000002623 67.0
HFD2_k127_1388766_22 PFAM DSBA-like thioredoxin domain - - - 0.0000001218 63.0
HFD2_k127_1388766_23 Tetratricopeptide repeat - - - 0.0000002688 63.0
HFD2_k127_1388766_24 domain, Protein - - - 0.000003204 58.0
HFD2_k127_1388766_3 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 486.0
HFD2_k127_1388766_4 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000083 445.0
HFD2_k127_1388766_5 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46,4.2.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 409.0
HFD2_k127_1388766_6 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 393.0
HFD2_k127_1388766_7 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 342.0
HFD2_k127_1388766_8 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 326.0
HFD2_k127_1388766_9 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000007708 230.0
HFD2_k127_1436498_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 563.0
HFD2_k127_1436498_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 432.0
HFD2_k127_1436498_2 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 348.0
HFD2_k127_1436498_3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000002689 243.0
HFD2_k127_1436498_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000003365 221.0
HFD2_k127_1436498_5 PFAM Copper binding periplasmic protein CusF K07152 - - 0.000000000000000000000000000000000000000000003279 175.0
HFD2_k127_1436498_6 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000663 171.0
HFD2_k127_1436498_7 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000001659 133.0
HFD2_k127_1436498_8 cellulase activity - - - 0.00000000001445 77.0
HFD2_k127_1436498_9 Cytochrome c K00406,K08906 - - 0.000000001988 69.0
HFD2_k127_1513929_0 Involved in the tonB-independent uptake of proteins - - - 1.393e-203 663.0
HFD2_k127_1513929_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 544.0
HFD2_k127_1513929_2 Protein of unknown function (DUF1326) - - - 0.0000000000001773 74.0
HFD2_k127_1714317_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 313.0
HFD2_k127_1714317_1 PFAM Peptidase family M20 M25 M40 K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 321.0
HFD2_k127_1714317_10 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000002162 139.0
HFD2_k127_1714317_11 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000002836 108.0
HFD2_k127_1714317_12 - - - - 0.00000000000000000001134 106.0
HFD2_k127_1714317_13 Sodium:solute symporter family K03307 - - 0.00000000000000000004788 104.0
HFD2_k127_1714317_14 Transcriptional regulatory protein, C terminal - - - 0.00000000000008173 79.0
HFD2_k127_1714317_15 - - - - 0.00000000172 69.0
HFD2_k127_1714317_17 Domain of unknown function (DUF4149) - - - 0.000004584 59.0
HFD2_k127_1714317_18 - - - - 0.00001027 58.0
HFD2_k127_1714317_2 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 293.0
HFD2_k127_1714317_3 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001988 280.0
HFD2_k127_1714317_4 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008722 291.0
HFD2_k127_1714317_5 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002955 290.0
HFD2_k127_1714317_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000002744 249.0
HFD2_k127_1714317_7 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000007333 232.0
HFD2_k127_1714317_8 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001234 221.0
HFD2_k127_1714317_9 GAF domain K08968 - 1.8.4.14 0.000000000000000000000000000000000000000000000000001118 202.0
HFD2_k127_1801553_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.383e-258 814.0
HFD2_k127_1801553_1 Ammonium Transporter K03320 - - 1.562e-195 617.0
HFD2_k127_1801553_10 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000001573 251.0
HFD2_k127_1801553_11 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000000000000000000000000000000001564 205.0
HFD2_k127_1801553_12 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000177 206.0
HFD2_k127_1801553_13 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000001605 191.0
HFD2_k127_1801553_14 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000001168 179.0
HFD2_k127_1801553_15 transcriptional regulator - - - 0.00000000000000000000000000000000000000218 171.0
HFD2_k127_1801553_16 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000002705 151.0
HFD2_k127_1801553_17 - - - - 0.0000000000000000000000000663 120.0
HFD2_k127_1801553_18 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000005136 113.0
HFD2_k127_1801553_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 474.0
HFD2_k127_1801553_21 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0001503 53.0
HFD2_k127_1801553_3 Belongs to the PstS family K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 410.0
HFD2_k127_1801553_4 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 405.0
HFD2_k127_1801553_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 377.0
HFD2_k127_1801553_6 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 367.0
HFD2_k127_1801553_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 304.0
HFD2_k127_1801553_8 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006135 289.0
HFD2_k127_1801553_9 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000186 277.0
HFD2_k127_1802153_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1400.0
HFD2_k127_1802153_1 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 349.0
HFD2_k127_1802153_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 343.0
HFD2_k127_1802153_3 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 327.0
HFD2_k127_1802153_4 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.00000000000000000000000000000000000000000005943 181.0
HFD2_k127_1802153_5 - - - - 0.0000000000000000000000000000002555 130.0
HFD2_k127_1810816_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 567.0
HFD2_k127_1810816_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 548.0
HFD2_k127_1810816_2 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 533.0
HFD2_k127_1810816_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003628 359.0
HFD2_k127_1810816_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 337.0
HFD2_k127_1810816_5 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000001014 230.0
HFD2_k127_1810816_6 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000002138 126.0
HFD2_k127_1810816_7 Nudix hydrolase - - - 0.0000000000000000000000002932 112.0
HFD2_k127_1830790_0 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003012 602.0
HFD2_k127_1830790_1 - - - - 0.00000000000000000005004 92.0
HFD2_k127_1830790_2 Carbohydrate family 9 binding domain-like - - - 0.000000000000000004791 88.0
HFD2_k127_1842155_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009922 524.0
HFD2_k127_1842155_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 510.0
HFD2_k127_1842155_10 Protein of unknown function (DUF805) - - - 0.000000000000000000006651 96.0
HFD2_k127_1842155_2 4Fe-4S binding domain K08358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 331.0
HFD2_k127_1842155_3 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000002145 258.0
HFD2_k127_1842155_4 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001661 250.0
HFD2_k127_1842155_5 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000006536 234.0
HFD2_k127_1842155_6 - - - - 0.000000000000000000000000000000000000001334 154.0
HFD2_k127_1842155_7 PFAM Curli production assembly transport component CsgG - - - 0.0000000000000000000000000000001007 137.0
HFD2_k127_1842155_8 DinB family - - - 0.000000000000000000000000000005322 124.0
HFD2_k127_1842155_9 - - - - 0.000000000000000000000000008108 120.0
HFD2_k127_1851037_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.000000000000000000000000000000000000000000000000001011 208.0
HFD2_k127_1851037_1 STAS domain K04749 - - 0.00000000000001473 82.0
HFD2_k127_1862542_0 Involved in the tonB-independent uptake of proteins - - - 4.232e-212 689.0
HFD2_k127_1862542_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 385.0
HFD2_k127_1862542_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000003652 250.0
HFD2_k127_1862542_3 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000003814 66.0
HFD2_k127_1868487_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.68e-220 697.0
HFD2_k127_1868487_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 5.275e-195 619.0
HFD2_k127_1868487_2 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004002 291.0
HFD2_k127_1868487_3 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000004982 148.0
HFD2_k127_1875014_0 Sortilin, neurotensin receptor 3, - - - 0.0 1132.0
HFD2_k127_1875014_1 tRNA synthetases class I (K) K01870 - 6.1.1.5 9.245e-284 908.0
HFD2_k127_1875014_10 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006444 286.0
HFD2_k127_1875014_11 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002639 288.0
HFD2_k127_1875014_12 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000006882 264.0
HFD2_k127_1875014_13 COG0512 Anthranilate para-aminobenzoate synthases component II K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000001505 227.0
HFD2_k127_1875014_14 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000001743 229.0
HFD2_k127_1875014_15 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000002655 229.0
HFD2_k127_1875014_16 Histidinol phosphate phosphatase, HisJ family K04486 - 3.1.3.15 0.000000000000000000000000000000000000000000000000000000000000002991 237.0
HFD2_k127_1875014_17 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000003285 242.0
HFD2_k127_1875014_18 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000127 229.0
HFD2_k127_1875014_19 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000001305 220.0
HFD2_k127_1875014_2 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 6.554e-194 614.0
HFD2_k127_1875014_20 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000003739 209.0
HFD2_k127_1875014_21 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.00000000000000000000000000000000000000000000000000001324 214.0
HFD2_k127_1875014_22 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000001742 209.0
HFD2_k127_1875014_23 Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000007181 194.0
HFD2_k127_1875014_24 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000001663 192.0
HFD2_k127_1875014_25 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000004839 175.0
HFD2_k127_1875014_26 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000004905 169.0
HFD2_k127_1875014_27 Belongs to the TrpC family K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.000000000000000000000000000000000000002744 166.0
HFD2_k127_1875014_28 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000006051 160.0
HFD2_k127_1875014_29 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000001617 150.0
HFD2_k127_1875014_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008538 497.0
HFD2_k127_1875014_30 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.000000000000000000000000000000000005087 154.0
HFD2_k127_1875014_31 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000003752 142.0
HFD2_k127_1875014_32 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000006561 135.0
HFD2_k127_1875014_33 iron ion homeostasis - - - 0.0000000000000000000000000000004211 142.0
HFD2_k127_1875014_34 histidine biosynthetic process K00765,K01892,K02502 - 2.4.2.17,6.1.1.21 0.0000000000000000000000000005727 127.0
HFD2_k127_1875014_35 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997,K18014 - 2.7.8.7,4.3.1.14 0.0000000000000000000000002923 111.0
HFD2_k127_1875014_36 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000003525 113.0
HFD2_k127_1875014_37 COGs COG1426 conserved - - - 0.0000000000000000002477 98.0
HFD2_k127_1875014_38 - - - - 0.000000000000000002326 98.0
HFD2_k127_1875014_39 - - - - 0.000000001191 72.0
HFD2_k127_1875014_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 488.0
HFD2_k127_1875014_40 DnaJ molecular chaperone homology domain K05516 - - 0.000000004494 66.0
HFD2_k127_1875014_5 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 428.0
HFD2_k127_1875014_6 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 426.0
HFD2_k127_1875014_7 ATP-dependent helicase activity K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 395.0
HFD2_k127_1875014_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 295.0
HFD2_k127_1875014_9 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001436 285.0
HFD2_k127_1886025_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006713 327.0
HFD2_k127_1886025_1 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000001507 131.0
HFD2_k127_1886025_2 Required for chromosome condensation and partitioning K03529 - - 0.00000000005622 67.0
HFD2_k127_1886025_3 sequence-specific DNA binding - - - 0.00000001012 63.0
HFD2_k127_1897488_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 3.886e-253 794.0
HFD2_k127_1897488_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 608.0
HFD2_k127_1897488_10 TIGRFAM hydrogenase nickel insertion protein HypA K04651 - - 0.00000000000000000000000000000000005057 136.0
HFD2_k127_1897488_11 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000005015 93.0
HFD2_k127_1897488_12 PFAM phosphoesterase, PA-phosphatase related - - - 0.000000000000000038 95.0
HFD2_k127_1897488_14 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000001772 68.0
HFD2_k127_1897488_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 507.0
HFD2_k127_1897488_3 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007078 475.0
HFD2_k127_1897488_4 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 395.0
HFD2_k127_1897488_5 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 385.0
HFD2_k127_1897488_6 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 350.0
HFD2_k127_1897488_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000001776 229.0
HFD2_k127_1897488_8 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000000000001214 204.0
HFD2_k127_1897488_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000003018 167.0
HFD2_k127_1979662_0 peptidase K07386 - - 8.842e-302 939.0
HFD2_k127_1979662_1 Involved in the tonB-independent uptake of proteins - - - 6.835e-225 728.0
HFD2_k127_1979662_2 Tetratricopeptide repeat - - - 1.183e-211 672.0
HFD2_k127_1979662_3 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003136 288.0
HFD2_k127_1979662_4 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000006236 252.0
HFD2_k127_1979662_5 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000003472 133.0
HFD2_k127_1979662_6 Metallophosphoesterase - - - 0.00000000000000000000000000002243 121.0
HFD2_k127_1979662_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000001155 100.0
HFD2_k127_1979662_8 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.000000000000000003237 93.0
HFD2_k127_1982415_0 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000053 205.0
HFD2_k127_1982415_1 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000002156 192.0
HFD2_k127_1982415_2 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000002217 119.0
HFD2_k127_2000293_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 8.361e-244 774.0
HFD2_k127_2000293_1 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 602.0
HFD2_k127_2000293_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000441 285.0
HFD2_k127_2000293_11 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000003375 242.0
HFD2_k127_2000293_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000007227 238.0
HFD2_k127_2000293_13 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000006836 198.0
HFD2_k127_2000293_14 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000001898 173.0
HFD2_k127_2000293_15 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000003452 160.0
HFD2_k127_2000293_16 von Willebrand factor, type A - - - 0.0000000000000000000000000000000006908 153.0
HFD2_k127_2000293_17 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000002038 138.0
HFD2_k127_2000293_18 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000001678 137.0
HFD2_k127_2000293_19 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000000000000000000000004531 126.0
HFD2_k127_2000293_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 535.0
HFD2_k127_2000293_20 Diguanylate cyclase - - - 0.0000000000000000000000000004113 128.0
HFD2_k127_2000293_21 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000007974 121.0
HFD2_k127_2000293_22 Preprotein translocase subunit K03210 - - 0.00000000000000000000004964 102.0
HFD2_k127_2000293_23 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000001357 87.0
HFD2_k127_2000293_24 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000005451 82.0
HFD2_k127_2000293_25 Tetratricopeptide repeat K00661,K18626 - 2.3.1.79 0.000000000004405 78.0
HFD2_k127_2000293_26 Roadblock/LC7 domain - - - 0.00000000002721 71.0
HFD2_k127_2000293_27 Protein of unknown function (FYDLN_acid) - - - 0.0000000002942 68.0
HFD2_k127_2000293_28 Belongs to the UPF0235 family K09131 - - 0.000000000369 67.0
HFD2_k127_2000293_29 Peptidase M56 - - - 0.000000003154 71.0
HFD2_k127_2000293_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 445.0
HFD2_k127_2000293_30 Tetratricopeptide repeat - - - 0.00000003456 64.0
HFD2_k127_2000293_32 Cell surface receptor IPT TIG - - - 0.000001433 62.0
HFD2_k127_2000293_33 Protein of unknown function (DUF721) - - - 0.0009052 47.0
HFD2_k127_2000293_4 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 374.0
HFD2_k127_2000293_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 336.0
HFD2_k127_2000293_6 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008149 334.0
HFD2_k127_2000293_7 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 332.0
HFD2_k127_2000293_8 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 329.0
HFD2_k127_2000293_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005465 294.0
HFD2_k127_2001760_0 Urocanase C-terminal domain K01712 - 4.2.1.49 1.071e-256 807.0
HFD2_k127_2001760_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 3.693e-206 680.0
HFD2_k127_2001760_10 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000003247 175.0
HFD2_k127_2001760_11 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000003723 170.0
HFD2_k127_2001760_12 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000009158 160.0
HFD2_k127_2001760_13 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000003425 172.0
HFD2_k127_2001760_14 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000004932 157.0
HFD2_k127_2001760_15 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000001642 147.0
HFD2_k127_2001760_16 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000002256 140.0
HFD2_k127_2001760_17 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.00000000000000000000000000000001613 146.0
HFD2_k127_2001760_18 Could be involved in septation K06412 - - 0.000000000000000000000000000004207 125.0
HFD2_k127_2001760_19 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000003406 115.0
HFD2_k127_2001760_2 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 496.0
HFD2_k127_2001760_20 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000001062 104.0
HFD2_k127_2001760_21 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000006753 100.0
HFD2_k127_2001760_22 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000002322 94.0
HFD2_k127_2001760_23 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000407 87.0
HFD2_k127_2001760_24 Glycoprotease family K01409,K14742 - 2.3.1.234 0.0000000000000007613 93.0
HFD2_k127_2001760_25 polysaccharide deacetylase - - - 0.00000000126 70.0
HFD2_k127_2001760_26 Predicted membrane protein (DUF2232) - - - 0.0000001465 63.0
HFD2_k127_2001760_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 416.0
HFD2_k127_2001760_4 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 397.0
HFD2_k127_2001760_5 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 342.0
HFD2_k127_2001760_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000002264 224.0
HFD2_k127_2001760_7 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000002505 211.0
HFD2_k127_2001760_8 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 0.00000000000000000000000000000000000000000000000000000003682 226.0
HFD2_k127_2001760_9 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000001895 177.0
HFD2_k127_2003125_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 4.398e-290 911.0
HFD2_k127_2003125_1 PAS fold-4 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 612.0
HFD2_k127_2003125_10 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 304.0
HFD2_k127_2003125_11 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000282 271.0
HFD2_k127_2003125_12 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002163 283.0
HFD2_k127_2003125_13 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000006474 268.0
HFD2_k127_2003125_14 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000001503 244.0
HFD2_k127_2003125_15 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000002576 223.0
HFD2_k127_2003125_16 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000002736 221.0
HFD2_k127_2003125_17 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000001872 181.0
HFD2_k127_2003125_18 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000005517 190.0
HFD2_k127_2003125_19 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000001924 169.0
HFD2_k127_2003125_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 554.0
HFD2_k127_2003125_20 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000574 153.0
HFD2_k127_2003125_21 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000001374 135.0
HFD2_k127_2003125_22 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000008648 131.0
HFD2_k127_2003125_23 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000004505 131.0
HFD2_k127_2003125_24 FR47-like protein K03789 - 2.3.1.128 0.0000000000000000000007367 104.0
HFD2_k127_2003125_25 phosphorelay signal transduction system - - - 0.0000000000000000001267 100.0
HFD2_k127_2003125_26 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.000000000000000000535 97.0
HFD2_k127_2003125_27 chlorophyll binding - - - 0.0000000000000001125 93.0
HFD2_k127_2003125_28 PFAM blue (type 1) copper domain protein - - - 0.0000000000000005478 87.0
HFD2_k127_2003125_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009728 509.0
HFD2_k127_2003125_4 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 471.0
HFD2_k127_2003125_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 419.0
HFD2_k127_2003125_6 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 373.0
HFD2_k127_2003125_7 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 350.0
HFD2_k127_2003125_8 Glutamate formiminotransferase K00603,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 357.0
HFD2_k127_2003125_9 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 345.0
HFD2_k127_2019694_0 ABC transporter K06020 - 3.6.3.25 4.427e-256 805.0
HFD2_k127_2019694_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 553.0
HFD2_k127_2019694_2 Beta-lactamase superfamily domain K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005915 268.0
HFD2_k127_2019694_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000001453 194.0
HFD2_k127_2019694_4 Protein of unknown function (DUF983) - - - 0.000000000005034 73.0
HFD2_k127_2115059_0 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 528.0
HFD2_k127_2115059_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 401.0
HFD2_k127_2115059_2 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 306.0
HFD2_k127_2115059_3 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000001837 238.0
HFD2_k127_2115059_4 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000000000002929 162.0
HFD2_k127_2115059_5 Adenylate cyclase - - - 0.00000000000000006788 89.0
HFD2_k127_2115059_6 ABC-2 type transporter - - - 0.0000000002982 69.0
HFD2_k127_2138672_0 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008982 327.0
HFD2_k127_2138672_1 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 301.0
HFD2_k127_2138672_10 Methionine biosynthesis protein MetW K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000001329 152.0
HFD2_k127_2138672_11 sigma factor antagonist activity K04757 - 2.7.11.1 0.0000000000000000000000001451 113.0
HFD2_k127_2138672_12 DNA polymerase III, delta' K02341 - 2.7.7.7 0.000000000000000000004711 106.0
HFD2_k127_2138672_13 antisigma factor binding - - - 0.0000000000000000001889 96.0
HFD2_k127_2138672_14 Transcriptional regulatory protein, C terminal - - - 0.000000000000000002778 98.0
HFD2_k127_2138672_15 Acetyltransferase (GNAT) domain - - - 0.00000000000006586 84.0
HFD2_k127_2138672_16 Glycosyl transferase, family 2 - - - 0.0000000000001203 85.0
HFD2_k127_2138672_17 PFAM glycosyl transferase group 1 - - - 0.000000000003389 79.0
HFD2_k127_2138672_18 PFAM PEGA domain - - - 0.00001767 57.0
HFD2_k127_2138672_2 Glycosyltransferase, group 2 family protein - - - 0.0000000000000000000000000000000000000000000000000000000006683 224.0
HFD2_k127_2138672_3 Glycosyl transferase family group 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000313 203.0
HFD2_k127_2138672_4 Serine phosphatase RsbU regulator of sigma subunit K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000002792 203.0
HFD2_k127_2138672_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000001178 205.0
HFD2_k127_2138672_6 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000002214 180.0
HFD2_k127_2138672_7 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000001358 179.0
HFD2_k127_2138672_8 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000002484 163.0
HFD2_k127_2138672_9 Amidohydrolase family - - - 0.000000000000000000000000000000000007831 143.0
HFD2_k127_2163501_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 520.0
HFD2_k127_2163501_1 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 507.0
HFD2_k127_2163501_11 Peptidase family S51 K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.00000000000000000000000000000000000000000002188 164.0
HFD2_k127_2163501_12 Penicillinase repressor - - - 0.0000000000000000000000000000000005559 133.0
HFD2_k127_2163501_13 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000002761 136.0
HFD2_k127_2163501_14 hyperosmotic response - - - 0.000000000000000000000003377 110.0
HFD2_k127_2163501_15 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000002879 115.0
HFD2_k127_2163501_16 ThiS family K03636 - - 0.00000000000000005141 86.0
HFD2_k127_2163501_2 argininosuccinate lyase activity K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 445.0
HFD2_k127_2163501_3 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 424.0
HFD2_k127_2163501_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 373.0
HFD2_k127_2163501_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 355.0
HFD2_k127_2163501_6 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 354.0
HFD2_k127_2163501_7 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001303 275.0
HFD2_k127_2163501_8 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001366 272.0
HFD2_k127_2163501_9 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000001994 252.0
HFD2_k127_2179662_0 TIGRFAM FeS assembly protein SufB K09014 - - 6.41e-263 815.0
HFD2_k127_2179662_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 583.0
HFD2_k127_2179662_10 Lipase maturation factor - - - 0.00000000000000000000000000000000000000000000000000000000000005297 224.0
HFD2_k127_2179662_11 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000000000000000000000261 212.0
HFD2_k127_2179662_12 FeS assembly SUF system protein SufT - - - 0.000000000000000000000000000000000000000000000000000004711 200.0
HFD2_k127_2179662_13 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000002367 175.0
HFD2_k127_2179662_14 Carbon-nitrogen hydrolase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000002425 119.0
HFD2_k127_2179662_15 RNA recognition motif - - - 0.000000000000000000000000003609 117.0
HFD2_k127_2179662_16 Late embryogenesis abundant protein - - - 0.0000000000000000000003374 107.0
HFD2_k127_2179662_2 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008386 582.0
HFD2_k127_2179662_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 426.0
HFD2_k127_2179662_4 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 400.0
HFD2_k127_2179662_5 ABC transporter K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 386.0
HFD2_k127_2179662_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 390.0
HFD2_k127_2179662_7 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 361.0
HFD2_k127_2179662_8 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009103 292.0
HFD2_k127_2179662_9 deaminase K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000000000000006066 236.0
HFD2_k127_2196973_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 519.0
HFD2_k127_2196973_1 Glycosyltransferase like family 2 K20444 - - 0.000000000000000000000000000000000000000000000000000000001201 217.0
HFD2_k127_2196973_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000001956 158.0
HFD2_k127_2196973_3 - - - - 0.00000000000000000000001036 117.0
HFD2_k127_2237054_0 ATP-grasp domain K01905,K22224 - 6.2.1.13 1.565e-279 888.0
HFD2_k127_2237054_1 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005479 566.0
HFD2_k127_2237054_10 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000134 166.0
HFD2_k127_2237054_11 Alpha/beta hydrolase family - - - 0.0000000000000000000000000006926 125.0
HFD2_k127_2237054_12 Redoxin - - - 0.0000000000000001533 86.0
HFD2_k127_2237054_13 Winged helix DNA-binding domain - - - 0.000001346 56.0
HFD2_k127_2237054_2 Belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 537.0
HFD2_k127_2237054_3 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 479.0
HFD2_k127_2237054_4 Enoyl-CoA hydratase/isomerase K01715,K07537 - 4.2.1.100,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 371.0
HFD2_k127_2237054_5 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 325.0
HFD2_k127_2237054_6 peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001421 298.0
HFD2_k127_2237054_7 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000007924 244.0
HFD2_k127_2237054_8 PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000117 189.0
HFD2_k127_2237054_9 Peptidase family U32 K08303 - - 0.0000000000000000000000000000000000000000000002352 180.0
HFD2_k127_2320136_0 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 292.0
HFD2_k127_2320136_1 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006905 220.0
HFD2_k127_2320136_2 sequence-specific DNA binding K03719 - - 0.0000000000000000000000000000000000000000000009441 173.0
HFD2_k127_2320136_3 DinB family - - - 0.0000000000000000000000000000000006974 147.0
HFD2_k127_2320136_4 Putative cyclase - - - 0.00000000000000000000000000001201 134.0
HFD2_k127_2320136_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000004131 119.0
HFD2_k127_2433508_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.632e-259 840.0
HFD2_k127_2433508_1 B12 binding domain - - - 2.434e-230 722.0
HFD2_k127_2433508_10 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 417.0
HFD2_k127_2433508_11 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008692 427.0
HFD2_k127_2433508_12 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 428.0
HFD2_k127_2433508_13 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 376.0
HFD2_k127_2433508_14 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 310.0
HFD2_k127_2433508_15 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 321.0
HFD2_k127_2433508_16 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
HFD2_k127_2433508_17 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002903 288.0
HFD2_k127_2433508_18 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001342 284.0
HFD2_k127_2433508_19 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001092 281.0
HFD2_k127_2433508_2 IgA Peptidase M64 - - - 6.27e-219 687.0
HFD2_k127_2433508_20 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000005278 267.0
HFD2_k127_2433508_21 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 252.0
HFD2_k127_2433508_22 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001688 266.0
HFD2_k127_2433508_23 - - - - 0.00000000000000000000000000000000000000000000000000000000001667 213.0
HFD2_k127_2433508_24 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001987 213.0
HFD2_k127_2433508_25 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000003128 219.0
HFD2_k127_2433508_26 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000000001288 182.0
HFD2_k127_2433508_27 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000000000000000000000003188 184.0
HFD2_k127_2433508_28 - - - - 0.0000000000000000000000000000000000000006983 162.0
HFD2_k127_2433508_29 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000004209 150.0
HFD2_k127_2433508_3 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 567.0
HFD2_k127_2433508_30 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000002535 152.0
HFD2_k127_2433508_31 TIGRFAM Addiction module toxin, Txe YoeB - - - 0.0000000000000000000000000000000001517 134.0
HFD2_k127_2433508_32 Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000000000007202 135.0
HFD2_k127_2433508_33 glyoxalase III activity - - - 0.0000000000000000000000000000004392 132.0
HFD2_k127_2433508_35 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000000006833 120.0
HFD2_k127_2433508_36 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.00000000000000000000003266 113.0
HFD2_k127_2433508_38 Cell division protein FtsQ K03589 - - 0.00000002551 64.0
HFD2_k127_2433508_39 - - - - 0.00000005502 60.0
HFD2_k127_2433508_4 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 508.0
HFD2_k127_2433508_41 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000006563 57.0
HFD2_k127_2433508_42 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.000006774 55.0
HFD2_k127_2433508_43 peptidylprolyl isomerase K03769 - 5.2.1.8 0.00001659 57.0
HFD2_k127_2433508_44 Resolvase - - - 0.0000718 50.0
HFD2_k127_2433508_5 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 490.0
HFD2_k127_2433508_6 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 497.0
HFD2_k127_2433508_7 dna ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 462.0
HFD2_k127_2433508_8 PASTA domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 449.0
HFD2_k127_2433508_9 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 433.0
HFD2_k127_2501940_0 mRNA catabolic process K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 541.0
HFD2_k127_2501940_1 YmdB-like protein K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 320.0
HFD2_k127_2501940_2 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000008104 238.0
HFD2_k127_2501940_3 Glycosyl transferases group 1 - - - 0.000000000000000000000001821 116.0
HFD2_k127_2501940_4 Redoxin K03564 - 1.11.1.15 0.0000000000000000004564 90.0
HFD2_k127_2501940_5 Cell division protein ZapA K09888 - - 0.00000000001584 69.0
HFD2_k127_2501940_6 Redoxin K03564 - 1.11.1.15 0.0000000001926 70.0
HFD2_k127_2501940_7 Trm112p-like protein - - - 0.00001431 58.0
HFD2_k127_2622901_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.935e-286 909.0
HFD2_k127_2622901_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 356.0
HFD2_k127_2622901_10 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001757 89.0
HFD2_k127_2622901_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.00000000000000206 81.0
HFD2_k127_2622901_12 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000003471 66.0
HFD2_k127_2622901_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 329.0
HFD2_k127_2622901_3 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001199 280.0
HFD2_k127_2622901_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000001836 250.0
HFD2_k127_2622901_5 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.00000000000000000000000000000000000000000000000000000000003233 226.0
HFD2_k127_2622901_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000002488 199.0
HFD2_k127_2622901_7 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000009285 182.0
HFD2_k127_2622901_8 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000004858 148.0
HFD2_k127_2622901_9 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000005955 99.0
HFD2_k127_2685060_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 3.96e-286 898.0
HFD2_k127_2685060_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00244,K00278 GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 589.0
HFD2_k127_2685060_10 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 384.0
HFD2_k127_2685060_11 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 364.0
HFD2_k127_2685060_12 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 366.0
HFD2_k127_2685060_13 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 375.0
HFD2_k127_2685060_14 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 342.0
HFD2_k127_2685060_15 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 319.0
HFD2_k127_2685060_16 Allophanate hydrolase subunit 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007068 328.0
HFD2_k127_2685060_17 Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 328.0
HFD2_k127_2685060_18 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 306.0
HFD2_k127_2685060_19 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 316.0
HFD2_k127_2685060_2 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 545.0
HFD2_k127_2685060_20 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 289.0
HFD2_k127_2685060_21 ABC transporter permease K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001227 293.0
HFD2_k127_2685060_22 Belongs to the UPF0271 (lamB) family K07160 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003064 272.0
HFD2_k127_2685060_23 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000001992 267.0
HFD2_k127_2685060_24 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002193 281.0
HFD2_k127_2685060_25 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009666 258.0
HFD2_k127_2685060_26 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000000000000000001958 216.0
HFD2_k127_2685060_27 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000002355 218.0
HFD2_k127_2685060_28 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000004577 211.0
HFD2_k127_2685060_29 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000003122 211.0
HFD2_k127_2685060_3 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 498.0
HFD2_k127_2685060_30 4-hydroxy-tetrahydrodipicolinate reductase K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000005416 178.0
HFD2_k127_2685060_31 KR domain K07535 - - 0.000000000000000000000000000000000000000000000233 184.0
HFD2_k127_2685060_32 Oxidoreductase NAD-binding domain K02823 - - 0.0000000000000000000000000000000000000000000002659 177.0
HFD2_k127_2685060_33 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.000000000000000000000000000000000000000000002875 173.0
HFD2_k127_2685060_34 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000001814 153.0
HFD2_k127_2685060_35 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000001234 152.0
HFD2_k127_2685060_36 - - - - 0.00000000000000000000000000000002587 143.0
HFD2_k127_2685060_37 response to heat K07090 - - 0.0000000000000000000000000000005432 127.0
HFD2_k127_2685060_38 Putative esterase - - - 0.0000000000000000000000000000006822 134.0
HFD2_k127_2685060_39 cheY-homologous receiver domain - - - 0.000000000000000000000000000003445 139.0
HFD2_k127_2685060_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003492 496.0
HFD2_k127_2685060_40 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000001029 108.0
HFD2_k127_2685060_41 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.00000000000000101 90.0
HFD2_k127_2685060_42 Domain of unknown function (DUF4437) - - - 0.0000000000001107 81.0
HFD2_k127_2685060_43 Transcription factor zinc-finger K09981 - - 0.000000000004225 72.0
HFD2_k127_2685060_44 - - - - 0.000000000006715 72.0
HFD2_k127_2685060_45 response regulator, receiver - - - 0.0000000003381 69.0
HFD2_k127_2685060_46 - - - - 0.00001574 53.0
HFD2_k127_2685060_47 metalloprotease - - - 0.00002656 46.0
HFD2_k127_2685060_5 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 460.0
HFD2_k127_2685060_6 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 448.0
HFD2_k127_2685060_7 Aldehyde dehydrogenase family K00128,K00131 - 1.2.1.3,1.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 419.0
HFD2_k127_2685060_8 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 405.0
HFD2_k127_2685060_9 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009438 376.0
HFD2_k127_2693230_0 Glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2509.0
HFD2_k127_2693230_1 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 8.297e-256 804.0
HFD2_k127_2693230_10 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 473.0
HFD2_k127_2693230_11 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 444.0
HFD2_k127_2693230_12 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 419.0
HFD2_k127_2693230_13 Selenocysteine-specific translation elongation factor K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000471 420.0
HFD2_k127_2693230_14 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 381.0
HFD2_k127_2693230_15 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 349.0
HFD2_k127_2693230_16 Belongs to the cysteine synthase cystathionine beta- synthase family K01697,K01738 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 311.0
HFD2_k127_2693230_17 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 302.0
HFD2_k127_2693230_18 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001337 284.0
HFD2_k127_2693230_19 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000649 276.0
HFD2_k127_2693230_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.371e-232 737.0
HFD2_k127_2693230_20 Transcriptional regulator, LysR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002985 259.0
HFD2_k127_2693230_21 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001172 236.0
HFD2_k127_2693230_22 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000007444 182.0
HFD2_k127_2693230_23 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000003926 156.0
HFD2_k127_2693230_24 PFAM Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000003546 152.0
HFD2_k127_2693230_25 Probable zinc-ribbon domain - - - 0.00000000000000000000000000000008961 130.0
HFD2_k127_2693230_26 Yqey-like protein K09117 - - 0.0000000000000000000000000000002895 128.0
HFD2_k127_2693230_27 CYTH K05873 - 4.6.1.1 0.000000000000000000000000005227 119.0
HFD2_k127_2693230_28 Cysteine-rich secretory protein family - - - 0.000000000000000000000000005545 123.0
HFD2_k127_2693230_29 Mov34 MPN PAD-1 family protein - - - 0.000000000000000000000001506 112.0
HFD2_k127_2693230_3 Dehydratase family K01687 - 4.2.1.9 1.04e-222 704.0
HFD2_k127_2693230_30 3-deoxy-7-phosphoheptulonate synthase activity K00661,K03856,K04092,K04093,K04516,K04518,K14170,K14187 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5 0.000000000000000000000006637 113.0
HFD2_k127_2693230_31 PFAM ThiS family K03636 - - 0.00000000000000000000001029 108.0
HFD2_k127_2693230_32 - - - - 0.0000000000000000000007461 102.0
HFD2_k127_2693230_33 protein involved in tolerance to divalent cations K03926 GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - 0.0000000000000000037 91.0
HFD2_k127_2693230_34 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.00000000000001725 80.0
HFD2_k127_2693230_35 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 0.000000006053 64.0
HFD2_k127_2693230_36 acetolactate synthase K01653,K16785 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000001239 57.0
HFD2_k127_2693230_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.82e-210 684.0
HFD2_k127_2693230_5 acetolactate synthase K01576,K01652 - 2.2.1.6,4.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 601.0
HFD2_k127_2693230_6 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 552.0
HFD2_k127_2693230_7 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000062 527.0
HFD2_k127_2693230_8 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 479.0
HFD2_k127_2693230_9 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 487.0
HFD2_k127_273045_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001171 260.0
HFD2_k127_273045_1 PFAM ABC-2 type transporter K01992,K09690 - - 0.0000000000000000000000000000000000001321 151.0
HFD2_k127_273045_2 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000003634 124.0
HFD2_k127_273045_3 Helix-turn-helix XRE-family like proteins - - - 0.00007388 50.0
HFD2_k127_273045_4 transcriptional regulator, SARP family - - - 0.0003208 52.0
HFD2_k127_2783665_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 429.0
HFD2_k127_2783665_1 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008984 378.0
HFD2_k127_2783665_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 315.0
HFD2_k127_2787951_0 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 6.655e-215 686.0
HFD2_k127_2787951_1 Alpha beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 285.0
HFD2_k127_2787951_2 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001133 266.0
HFD2_k127_2787951_3 Thioesterase - - - 0.000000000000000000000000000000002009 133.0
HFD2_k127_2823440_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 476.0
HFD2_k127_2823440_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 366.0
HFD2_k127_2823440_10 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000007668 132.0
HFD2_k127_2823440_11 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000000000004873 126.0
HFD2_k127_2823440_12 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000002529 89.0
HFD2_k127_2823440_13 Belongs to the UPF0109 family K06960 - - 0.000000001077 66.0
HFD2_k127_2823440_2 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 308.0
HFD2_k127_2823440_3 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 302.0
HFD2_k127_2823440_4 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000003601 239.0
HFD2_k127_2823440_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000003844 237.0
HFD2_k127_2823440_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000009786 200.0
HFD2_k127_2823440_7 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000002528 176.0
HFD2_k127_2823440_8 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000001191 160.0
HFD2_k127_2823440_9 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000000000002866 153.0
HFD2_k127_2864284_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 2.113e-247 772.0
HFD2_k127_2864284_1 Transport of potassium into the cell K03549 - - 2.549e-239 757.0
HFD2_k127_2864284_2 Transport of potassium into the cell K03549 - - 1.498e-202 653.0
HFD2_k127_2864284_3 Ring hydroxylating alpha subunit (catalytic domain) K00479,K00499 - 1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 388.0
HFD2_k127_2864284_4 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000001066 226.0
HFD2_k127_2864284_5 - - - - 0.000000000000000000000000000000000000000000000000000000001582 220.0
HFD2_k127_2864284_6 response to abiotic stimulus - - - 0.0000000000000000000000000000000000000006771 168.0
HFD2_k127_2864284_7 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000007944 162.0
HFD2_k127_2864284_8 phosphoglycerate mutase - - - 0.00000000000000000001677 102.0
HFD2_k127_2864284_9 PFAM Rieske 2Fe-2S domain protein K00363,K05710 - 1.7.1.15 0.00000000000000003358 89.0
HFD2_k127_2890037_0 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 349.0
HFD2_k127_2890037_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 351.0
HFD2_k127_2890037_2 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 328.0
HFD2_k127_2890037_3 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009932 293.0
HFD2_k127_2890037_4 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000006217 205.0
HFD2_k127_2890037_5 Belongs to the HAM1 NTPase family K02428 - 3.6.1.66 0.0000000000000000000000000000000000003804 146.0
HFD2_k127_2890037_6 - - - - 0.00000000000686 72.0
HFD2_k127_2890037_7 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000008781 65.0
HFD2_k127_2902142_0 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 497.0
HFD2_k127_2902142_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 357.0
HFD2_k127_2902142_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 351.0
HFD2_k127_2902142_3 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 308.0
HFD2_k127_2902142_4 - - - - 0.0000000000002202 76.0
HFD2_k127_2902142_5 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000006749 76.0
HFD2_k127_2902142_6 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000003715 59.0
HFD2_k127_2902142_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0001912 53.0
HFD2_k127_294982_0 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008967 574.0
HFD2_k127_294982_1 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 496.0
HFD2_k127_294982_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004806 284.0
HFD2_k127_294982_3 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000000000001319 222.0
HFD2_k127_294982_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000006232 214.0
HFD2_k127_294982_5 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000004765 206.0
HFD2_k127_294982_6 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000004794 169.0
HFD2_k127_294982_7 cheY-homologous receiver domain - - - 0.0000000000000000000000000001822 121.0
HFD2_k127_294982_8 COG0665 Glycine D-amino acid oxidases (deaminating) - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - 0.0000000000000000000001569 98.0
HFD2_k127_294982_9 phosphorelay signal transduction system - - - 0.00000000000000003442 92.0
HFD2_k127_3007747_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.51e-271 852.0
HFD2_k127_3007747_1 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 520.0
HFD2_k127_3007747_2 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000009116 101.0
HFD2_k127_3007747_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000116 59.0
HFD2_k127_3035830_0 Heat shock 70 kDa protein K04043 - - 3.124e-303 940.0
HFD2_k127_3035830_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 487.0
HFD2_k127_3035830_10 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000001366 228.0
HFD2_k127_3035830_11 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.0000000000000000000000000000000000000000000000000000000000000141 229.0
HFD2_k127_3035830_12 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000003683 230.0
HFD2_k127_3035830_13 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000000000000000001412 188.0
HFD2_k127_3035830_14 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000001611 186.0
HFD2_k127_3035830_15 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000001678 169.0
HFD2_k127_3035830_16 COG4942 Membrane-bound metallopeptidase - GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.000000000000000000000000000000000009468 154.0
HFD2_k127_3035830_17 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000002198 147.0
HFD2_k127_3035830_18 Thioesterase superfamily K10806 - - 0.000000000000000000000000000000007194 131.0
HFD2_k127_3035830_19 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000007171 129.0
HFD2_k127_3035830_2 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 456.0
HFD2_k127_3035830_20 PFAM von Willebrand factor type A K07114 - - 0.00000000000000000000000000000469 134.0
HFD2_k127_3035830_21 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.000000000000000000000000000009629 132.0
HFD2_k127_3035830_22 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000009824 124.0
HFD2_k127_3035830_23 MerR HTH family regulatory protein K13640 - - 0.0000000000000000000000000004355 122.0
HFD2_k127_3035830_24 Domain of unknown function (DUF1844) - - - 0.000000000000003305 82.0
HFD2_k127_3035830_25 Tetratricopeptide repeat - - - 0.0000000000002491 83.0
HFD2_k127_3035830_26 Peptidase M56 - - - 0.0000000001805 74.0
HFD2_k127_3035830_27 - - - - 0.0000000003422 70.0
HFD2_k127_3035830_28 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000004431 60.0
HFD2_k127_3035830_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 410.0
HFD2_k127_3035830_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 400.0
HFD2_k127_3035830_5 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 391.0
HFD2_k127_3035830_6 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 338.0
HFD2_k127_3035830_7 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008366 286.0
HFD2_k127_3035830_8 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000001866 282.0
HFD2_k127_3035830_9 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000001948 224.0
HFD2_k127_3324419_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 591.0
HFD2_k127_3324419_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 367.0
HFD2_k127_3324419_2 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000002306 199.0
HFD2_k127_3324419_3 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000000000005806 185.0
HFD2_k127_3324419_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000004615 160.0
HFD2_k127_3324419_5 Zn peptidase - - - 0.000000000000000000000000000000000007278 152.0
HFD2_k127_3324419_6 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000000000000000000000000001721 132.0
HFD2_k127_3324419_7 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.0000000000000000000000000009103 117.0
HFD2_k127_3324419_8 Protein of unknown function (DUF2905) - - - 0.00000000001203 76.0
HFD2_k127_3324419_9 metal-dependent membrane protease K07052 - - 0.00006318 53.0
HFD2_k127_3507286_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1318.0
HFD2_k127_3507286_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00322 - 1.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 620.0
HFD2_k127_3507286_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000003211 83.0
HFD2_k127_3507286_2 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 467.0
HFD2_k127_3507286_3 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 307.0
HFD2_k127_3507286_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000002991 271.0
HFD2_k127_3507286_5 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000151 251.0
HFD2_k127_3507286_6 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.0000000000000000000000000000000000000000000000000000004308 212.0
HFD2_k127_3507286_7 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000002912 200.0
HFD2_k127_3507286_8 Domain of unknown function (DUF4136) - - - 0.000000000000000000000002365 119.0
HFD2_k127_3507286_9 cheY-homologous receiver domain - - - 0.00000000000000000001262 104.0
HFD2_k127_3509707_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 433.0
HFD2_k127_3509707_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007396 376.0
HFD2_k127_3509707_10 Protein of unknown function (DUF2834) - - - 0.0000000000000000000000000000000000002566 145.0
HFD2_k127_3509707_11 EthD domain - - - 0.000000000000000000000000001052 115.0
HFD2_k127_3509707_12 SAM (And some other nucleotide) binding motif - - - 0.00000000000000000000000001345 110.0
HFD2_k127_3509707_13 methyltransferase activity - - - 0.000000000000652 75.0
HFD2_k127_3509707_14 RibD C-terminal domain - - - 0.0001007 52.0
HFD2_k127_3509707_2 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004166 246.0
HFD2_k127_3509707_3 PASTA K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000002624 229.0
HFD2_k127_3509707_4 COG0840 Methyl-accepting chemotaxis protein - - - 0.00000000000000000000000000000000000000000000000000000000000004799 228.0
HFD2_k127_3509707_5 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000000000000000000000000000000005732 213.0
HFD2_k127_3509707_6 TspO MBR family protein K05770 - - 0.00000000000000000000000000000000000000000000000000000006765 202.0
HFD2_k127_3509707_7 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000002496 167.0
HFD2_k127_3509707_8 Haem-binding domain - - - 0.0000000000000000000000000000000000000002542 154.0
HFD2_k127_3509707_9 Berberine and berberine like - - - 0.00000000000000000000000000000000000006997 145.0
HFD2_k127_3513678_0 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 2.034e-302 944.0
HFD2_k127_3513678_1 PFAM Glycoside hydrolase 15-related K01178 - 3.2.1.3 1.821e-270 846.0
HFD2_k127_3513678_2 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 409.0
HFD2_k127_3513678_3 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000000000003416 203.0
HFD2_k127_3513678_4 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000152 133.0
HFD2_k127_3525729_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.644e-195 621.0
HFD2_k127_3525729_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 584.0
HFD2_k127_3525729_10 von Willebrand factor (vWF) type A domain K07114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009768 380.0
HFD2_k127_3525729_11 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 363.0
HFD2_k127_3525729_12 Zinc-binding dehydrogenase K07538 - 1.1.1.368 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009849 368.0
HFD2_k127_3525729_13 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 335.0
HFD2_k127_3525729_14 Phosphoesterase family K21302 - 3.1.3.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007821 328.0
HFD2_k127_3525729_15 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 316.0
HFD2_k127_3525729_16 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 321.0
HFD2_k127_3525729_17 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 307.0
HFD2_k127_3525729_18 ABC transporter, ATP-binding protein K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000371 291.0
HFD2_k127_3525729_19 ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001247 284.0
HFD2_k127_3525729_2 benzoyl-CoA reductase K04113 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 578.0
HFD2_k127_3525729_20 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001596 269.0
HFD2_k127_3525729_21 ABC 3 transport family K09819,K11606,K11708,K11709 - - 0.00000000000000000000000000000000000000000000000000000000000000000001338 241.0
HFD2_k127_3525729_22 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000005743 237.0
HFD2_k127_3525729_23 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000002185 241.0
HFD2_k127_3525729_24 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005377 231.0
HFD2_k127_3525729_25 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000001199 220.0
HFD2_k127_3525729_26 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000003193 211.0
HFD2_k127_3525729_27 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000004782 211.0
HFD2_k127_3525729_28 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000001238 199.0
HFD2_k127_3525729_29 DinB family - - - 0.0000000000000000000000000000000000000000000000008749 183.0
HFD2_k127_3525729_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 558.0
HFD2_k127_3525729_30 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000136 176.0
HFD2_k127_3525729_31 Cytochrome c K00406,K16255 - - 0.000000000000000000000000000000000000000000033 177.0
HFD2_k127_3525729_32 ABC-2 family transporter protein K19341 - - 0.00000000000000000000000000000000000000001311 166.0
HFD2_k127_3525729_33 ABC transporter K01990,K19340 - - 0.00000000000000000000000000000000000000005386 170.0
HFD2_k127_3525729_34 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000005888 147.0
HFD2_k127_3525729_35 PIN domain - - - 0.0000000000000000000000000000000000003399 148.0
HFD2_k127_3525729_36 Belongs to the peptidase S41A family - - - 0.000000000000000000000000000000000008334 147.0
HFD2_k127_3525729_37 Spondin_N - - - 0.00000000000000000000000000000001876 138.0
HFD2_k127_3525729_38 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000003024 130.0
HFD2_k127_3525729_4 COG4263 Nitrous oxide reductase K00376 - 1.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 543.0
HFD2_k127_3525729_40 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000375 117.0
HFD2_k127_3525729_41 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000114 115.0
HFD2_k127_3525729_42 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide K01480 - 3.5.3.11 0.00000000000000000000002217 104.0
HFD2_k127_3525729_43 Pas domain - - - 0.00000000000000000000003917 109.0
HFD2_k127_3525729_44 Putative prokaryotic signal transducing protein - - - 0.00000000000000000001236 98.0
HFD2_k127_3525729_45 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000001357 96.0
HFD2_k127_3525729_46 - - - - 0.000000000000004112 77.0
HFD2_k127_3525729_47 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000007176 79.0
HFD2_k127_3525729_49 lipoprotein involved in nitrous oxide reduction K19342 - - 0.00000000018 73.0
HFD2_k127_3525729_5 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 469.0
HFD2_k127_3525729_6 BadF/BadG/BcrA/BcrD ATPase family K04114 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 466.0
HFD2_k127_3525729_7 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 464.0
HFD2_k127_3525729_8 benzoyl-CoA reductase K04112 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 410.0
HFD2_k127_3525729_9 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 399.0
HFD2_k127_3575173_0 Protein of unknown function, DUF255 K06888 - - 3.792e-208 667.0
HFD2_k127_3575173_1 penicillin amidase K01434 - 3.5.1.11 1.803e-204 661.0
HFD2_k127_3575173_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00172,K00441,K03522 - 1.12.98.1,1.2.7.1 0.0000000000000000000000002427 110.0
HFD2_k127_3575173_11 - - - - 0.000000000000000005296 97.0
HFD2_k127_3575173_12 PBS lyase HEAT-like repeat - - - 0.0000000003161 74.0
HFD2_k127_3575173_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 490.0
HFD2_k127_3575173_3 PFAM Cytochrome b b6 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 402.0
HFD2_k127_3575173_4 Cytochrome b(C-terminal)/b6/petD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 386.0
HFD2_k127_3575173_5 NAD-dependent histone deacetylase activity (H3-K14 specific) K11407 - 3.5.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009371 314.0
HFD2_k127_3575173_6 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000000000000000000000000000003856 240.0
HFD2_k127_3575173_7 LssY C-terminus - - - 0.0000000000000000000000000000000000000000000000000000003303 208.0
HFD2_k127_3575173_8 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000000000000000000000000000000005254 192.0
HFD2_k127_3575173_9 MobA-Related Protein K07141 - 2.7.7.76 0.00000000000000000000000000005788 131.0
HFD2_k127_3580946_0 Carboxypeptidase regulatory-like domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 377.0
HFD2_k127_3580946_1 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000201 290.0
HFD2_k127_3580946_2 - - - - 0.00000000000000000000000000000000000000000000000000007986 198.0
HFD2_k127_3580946_3 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000002273 165.0
HFD2_k127_3580946_4 Cytochrome c - - - 0.00000000000000000000000000000000000004824 155.0
HFD2_k127_3580946_5 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000001005 109.0
HFD2_k127_3580946_6 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.0000000000000001651 82.0
HFD2_k127_3580946_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000005323 76.0
HFD2_k127_3580946_9 iron ion homeostasis - - - 0.00005106 55.0
HFD2_k127_3588054_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 603.0
HFD2_k127_3588054_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 326.0
HFD2_k127_3588054_2 Bacterial regulatory protein, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003356 286.0
HFD2_k127_3588054_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000006569 248.0
HFD2_k127_3588054_4 Transmembrane and - - - 0.00000000000000000000000000000000000000000000001072 194.0
HFD2_k127_3588054_5 Subtilase family - - - 0.00000000000000000000000000000000000000001621 175.0
HFD2_k127_3588054_6 Subtilase family - - - 0.000000000000000000000000000000000000002982 170.0
HFD2_k127_3588054_7 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.00000000000000000000000000000000000005538 151.0
HFD2_k127_3588054_8 Hep Hag repeat protein - - - 0.00000000000000006958 94.0
HFD2_k127_3588054_9 - - - - 0.000000000000004679 89.0
HFD2_k127_3590194_0 Protein kinase domain K12132 - 2.7.11.1 2.072e-252 806.0
HFD2_k127_3590194_1 Protein kinase domain K12132 - 2.7.11.1 1.078e-220 713.0
HFD2_k127_3590194_2 cAMP biosynthetic process K00870,K12132 - 2.7.1.37,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 370.0
HFD2_k127_3611028_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.676e-232 732.0
HFD2_k127_3611028_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007449 560.0
HFD2_k127_3611028_10 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 295.0
HFD2_k127_3611028_11 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 308.0
HFD2_k127_3611028_12 DAHP synthetase I family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003831 291.0
HFD2_k127_3611028_13 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000001342 258.0
HFD2_k127_3611028_14 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001437 250.0
HFD2_k127_3611028_15 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000004416 223.0
HFD2_k127_3611028_16 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000007547 214.0
HFD2_k127_3611028_17 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000084 226.0
HFD2_k127_3611028_18 Belongs to the mannose-6-phosphate isomerase type 2 family K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000001544 215.0
HFD2_k127_3611028_19 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000146 201.0
HFD2_k127_3611028_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005262 479.0
HFD2_k127_3611028_20 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000004999 180.0
HFD2_k127_3611028_22 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000003239 115.0
HFD2_k127_3611028_23 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000003502 126.0
HFD2_k127_3611028_24 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000004082 99.0
HFD2_k127_3611028_25 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000001688 113.0
HFD2_k127_3611028_26 Protein of unknown function DUF58 - - - 0.00000000000000000003583 102.0
HFD2_k127_3611028_27 Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.0000000000000000003501 96.0
HFD2_k127_3611028_28 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000003661 92.0
HFD2_k127_3611028_29 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000001226 74.0
HFD2_k127_3611028_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 477.0
HFD2_k127_3611028_30 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000001484 68.0
HFD2_k127_3611028_31 Cytochrome c - - - 0.000000285 60.0
HFD2_k127_3611028_4 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 431.0
HFD2_k127_3611028_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 398.0
HFD2_k127_3611028_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 334.0
HFD2_k127_3611028_7 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 325.0
HFD2_k127_3611028_8 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 323.0
HFD2_k127_3611028_9 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 318.0
HFD2_k127_3622193_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 3.02e-312 978.0
HFD2_k127_3622193_1 Succinyl-CoA ligase like flavodoxin domain - - - 1.505e-242 779.0
HFD2_k127_3622193_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000001191 142.0
HFD2_k127_3622193_3 Domain of unknown function (DUF1858) - - - 0.0000000000000000003576 104.0
HFD2_k127_3622193_4 Belongs to the universal stress protein A family - - - 0.00000003709 61.0
HFD2_k127_3622193_5 Family of unknown function (DUF5335) - - - 0.00005384 51.0
HFD2_k127_3633156_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.053e-260 831.0
HFD2_k127_3633156_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 501.0
HFD2_k127_3633156_10 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000002034 183.0
HFD2_k127_3633156_11 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000001097 191.0
HFD2_k127_3633156_12 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.0000000000000000000000000000000000000000000001774 180.0
HFD2_k127_3633156_13 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000003376 170.0
HFD2_k127_3633156_14 type II secretion system protein G K02456 - - 0.000000000000000000000000000009237 124.0
HFD2_k127_3633156_15 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000003728 88.0
HFD2_k127_3633156_16 general secretion pathway protein K02456,K02650 - - 0.00000000000000678 88.0
HFD2_k127_3633156_17 bacterial OsmY and nodulation domain K04065 - - 0.000000004419 62.0
HFD2_k127_3633156_18 hyperosmotic response K04065 - - 0.00000005502 60.0
HFD2_k127_3633156_19 Psort location CytoplasmicMembrane, score - - - 0.00000162 59.0
HFD2_k127_3633156_2 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 477.0
HFD2_k127_3633156_20 Periplasmic or secreted lipoprotein K04065 - - 0.000267 51.0
HFD2_k127_3633156_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 478.0
HFD2_k127_3633156_4 Belongs to the peptidase M16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 340.0
HFD2_k127_3633156_5 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 346.0
HFD2_k127_3633156_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 310.0
HFD2_k127_3633156_7 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 295.0
HFD2_k127_3633156_8 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002899 306.0
HFD2_k127_3633156_9 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004803 273.0
HFD2_k127_3687198_0 Oligoendopeptidase f - - - 1.678e-254 809.0
HFD2_k127_3687198_1 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 624.0
HFD2_k127_3687198_10 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 304.0
HFD2_k127_3687198_11 oxidation-reduction process - - - 0.000000000000000000000000000000001099 147.0
HFD2_k127_3687198_12 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000005655 136.0
HFD2_k127_3687198_13 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000008576 106.0
HFD2_k127_3687198_14 Carbohydrate family 9 binding domain-like - - - 0.0000000000000000001372 94.0
HFD2_k127_3687198_15 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000005635 82.0
HFD2_k127_3687198_16 CHRD domain - - - 0.0000000007696 70.0
HFD2_k127_3687198_2 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 628.0
HFD2_k127_3687198_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 584.0
HFD2_k127_3687198_4 S-adenosyl-L-homocysteine hydrolase K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 518.0
HFD2_k127_3687198_5 secondary active sulfate transmembrane transporter activity K06901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 479.0
HFD2_k127_3687198_6 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 467.0
HFD2_k127_3687198_7 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 422.0
HFD2_k127_3687198_8 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 390.0
HFD2_k127_3687198_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 309.0
HFD2_k127_3689041_0 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 505.0
HFD2_k127_3689041_1 UDP binding domain K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 501.0
HFD2_k127_3689041_10 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.00000000000000000000000000000000000000001157 162.0
HFD2_k127_3689041_11 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000001863 156.0
HFD2_k127_3689041_12 4Fe-4S single cluster domain of Ferredoxin I - - - 0.000000000000000000000000000008648 120.0
HFD2_k127_3689041_13 MlaD protein K02067 - - 0.00000000000000000000000000001832 136.0
HFD2_k127_3689041_14 to the N-terminal domain of Lon protease K07157 - - 0.000000000000000000000000002444 124.0
HFD2_k127_3689041_15 PFAM Pentapeptide repeats (8 copies) - - - 0.000000000000000000000000005177 126.0
HFD2_k127_3689041_16 Domain of unknown function (DUF4340) - - - 0.0000000000000000002399 104.0
HFD2_k127_3689041_17 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 - 0.0000000000000009189 80.0
HFD2_k127_3689041_18 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000005553 73.0
HFD2_k127_3689041_19 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000002297 63.0
HFD2_k127_3689041_2 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 419.0
HFD2_k127_3689041_20 anaphase-promoting complex binding - - - 0.00002064 57.0
HFD2_k127_3689041_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 364.0
HFD2_k127_3689041_4 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 351.0
HFD2_k127_3689041_5 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001041 288.0
HFD2_k127_3689041_6 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009727 251.0
HFD2_k127_3689041_7 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000009427 248.0
HFD2_k127_3689041_8 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000402 252.0
HFD2_k127_3689041_9 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000006427 173.0
HFD2_k127_3690653_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00256 - 1.3.99.16 2.29e-238 764.0
HFD2_k127_3690653_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008726 393.0
HFD2_k127_3690653_2 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 317.0
HFD2_k127_3690653_3 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000008557 184.0
HFD2_k127_3690653_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000002191 186.0
HFD2_k127_3690653_5 AAA domain - - - 0.000000000000000000000000000000000000000000008028 167.0
HFD2_k127_3690653_6 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00256 - 1.3.99.16 0.0000000000000000000003605 98.0
HFD2_k127_37240_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001036 292.0
HFD2_k127_37240_1 Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002331 284.0
HFD2_k127_37240_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000003295 102.0
HFD2_k127_37240_3 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000000264 105.0
HFD2_k127_3759383_0 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 500.0
HFD2_k127_3759383_1 DNA-templated transcription, initiation K02405 - - 0.000000000000000000000000000000000000000002197 164.0
HFD2_k127_3759383_2 ECF sigma factor - - - 0.000000000000000000000000000000000000001092 151.0
HFD2_k127_3763317_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 3.26e-322 1001.0
HFD2_k127_3763317_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.991e-199 657.0
HFD2_k127_3763317_10 hyperosmotic response - - - 0.000000000000000000000000000001694 126.0
HFD2_k127_3763317_11 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000002644 113.0
HFD2_k127_3763317_12 periplasmic or secreted lipoprotein - - - 0.000000000000000000005151 100.0
HFD2_k127_3763317_13 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.0000000000000000001766 91.0
HFD2_k127_3763317_14 Cbs domain K04767 - - 0.000000000000000004716 93.0
HFD2_k127_3763317_15 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000000000000009307 87.0
HFD2_k127_3763317_16 Protein of unknown function (DUF1622) - - - 0.0000000000000004197 79.0
HFD2_k127_3763317_17 regulatory protein, arsR K22298 - - 0.000000000000001748 81.0
HFD2_k127_3763317_18 Protein of unknown function (DUF2892) - - - 0.000000000000001754 88.0
HFD2_k127_3763317_19 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000003011 81.0
HFD2_k127_3763317_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 485.0
HFD2_k127_3763317_20 Outer membrane efflux protein - - - 0.0000000008316 71.0
HFD2_k127_3763317_21 Protein conserved in bacteria - - - 0.000003296 50.0
HFD2_k127_3763317_3 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 324.0
HFD2_k127_3763317_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000001041 278.0
HFD2_k127_3763317_5 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001552 261.0
HFD2_k127_3763317_6 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001958 263.0
HFD2_k127_3763317_7 PFAM Hly-III family protein K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001748 256.0
HFD2_k127_3763317_8 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000000000000000000000454 204.0
HFD2_k127_3763317_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000004551 153.0
HFD2_k127_3799889_0 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 388.0
HFD2_k127_3799889_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000005949 213.0
HFD2_k127_3801935_0 Major facilitator superfamily K08167 - - 6.373e-194 620.0
HFD2_k127_3801935_1 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005486 503.0
HFD2_k127_3801935_2 DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006434 279.0
HFD2_k127_3801935_3 Hep Hag repeat protein - GO:0005575,GO:0005576 - 0.000000000000000000000000000000000000000000000000000000000003836 231.0
HFD2_k127_3801935_4 sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000151 111.0
HFD2_k127_3801935_6 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000003057 58.0
HFD2_k127_3878435_0 Protein kinase domain K12132 - 2.7.11.1 3.732e-251 803.0
HFD2_k127_3878435_1 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 521.0
HFD2_k127_3878435_2 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000688 527.0
HFD2_k127_3878435_3 PFAM Protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 456.0
HFD2_k127_3878435_4 Domain of Unknown Function (DUF1259) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 344.0
HFD2_k127_3878435_5 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002013 285.0
HFD2_k127_3878435_6 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002212 261.0
HFD2_k127_3878435_7 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000002805 203.0
HFD2_k127_3878435_8 cheY-homologous receiver domain - - - 0.000000000000000000002875 100.0
HFD2_k127_3905155_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 3.678e-219 706.0
HFD2_k127_3905155_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000001228 204.0
HFD2_k127_3905155_2 PIN domain - - - 0.0000000000002371 77.0
HFD2_k127_39105_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 1.994e-205 659.0
HFD2_k127_39105_1 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 611.0
HFD2_k127_39105_10 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000001677 180.0
HFD2_k127_39105_2 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005525 476.0
HFD2_k127_39105_3 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007368 430.0
HFD2_k127_39105_4 Cephalosporin hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 377.0
HFD2_k127_39105_5 Mechanosensitive ion channel K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000001557 241.0
HFD2_k127_39105_6 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000001311 212.0
HFD2_k127_39105_7 DNA primase activity - - - 0.000000000000000000000000000000000000000000000000000003063 193.0
HFD2_k127_39105_8 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000003033 202.0
HFD2_k127_39105_9 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000000007099 179.0
HFD2_k127_391901_0 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005608 391.0
HFD2_k127_391901_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000004046 78.0
HFD2_k127_391901_2 Protein of unknown function (DUF1573) - - - 0.00000000000002166 85.0
HFD2_k127_3924822_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 4.042e-278 878.0
HFD2_k127_3924822_1 Belongs to the HypD family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 502.0
HFD2_k127_3924822_10 Adenylylsulfate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000891 137.0
HFD2_k127_3924822_11 carbon dioxide binding K04653,K04654 - - 0.00000000000000000000000000006484 121.0
HFD2_k127_3924822_12 Biogenesis protein - - - 0.00000000000000000000001401 115.0
HFD2_k127_3924822_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000001118 77.0
HFD2_k127_3924822_14 - - - - 0.00000000001216 75.0
HFD2_k127_3924822_15 permease K07243 - - 0.00000003934 63.0
HFD2_k127_3924822_16 - - - - 0.0000003124 58.0
HFD2_k127_3924822_2 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 496.0
HFD2_k127_3924822_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003088 428.0
HFD2_k127_3924822_4 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 325.0
HFD2_k127_3924822_5 Domain of unknown function (DUF4405) - - - 0.00000000000000000000000000000000000000000000000000000001627 205.0
HFD2_k127_3924822_6 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000000369 188.0
HFD2_k127_3924822_7 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000001785 195.0
HFD2_k127_3924822_9 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.0000000000000000000000000000000003521 138.0
HFD2_k127_4016902_0 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 481.0
HFD2_k127_4016902_1 SMART band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 349.0
HFD2_k127_4016902_2 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.00000000000000000000000000000000000000000000005168 176.0
HFD2_k127_4016902_3 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000000000000000000000000000002261 144.0
HFD2_k127_4016902_4 Outer membrane receptor K02014,K16087 - - 0.00000000000000000000000000001343 137.0
HFD2_k127_4016902_5 PFAM Rhomboid family - - - 0.0000000000000000000002858 98.0
HFD2_k127_4016902_6 Protein of unknown function (DUF1343) - - - 0.0000003267 55.0
HFD2_k127_4021197_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 404.0
HFD2_k127_4021197_1 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 353.0
HFD2_k127_4021197_2 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004421 304.0
HFD2_k127_4021197_3 PIN domain - - - 0.000000000000000000000000003513 117.0
HFD2_k127_4021197_4 SpoVT / AbrB like domain - - - 0.00000000000001811 75.0
HFD2_k127_4021197_5 YsiA-like protein, C-terminal region K13770 - - 0.00000000000002118 80.0
HFD2_k127_4215512_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 292.0
HFD2_k127_4215512_1 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003415 265.0
HFD2_k127_4215512_2 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007106 251.0
HFD2_k127_4215512_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000009484 192.0
HFD2_k127_4215512_4 cheY-homologous receiver domain - - - 0.0000000000000000000000722 106.0
HFD2_k127_4215512_5 polysaccharide deacetylase - - - 0.0000000000003293 83.0
HFD2_k127_4215512_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K02005 - - 0.00000005481 64.0
HFD2_k127_4230144_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000395 310.0
HFD2_k127_4230144_1 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000003301 259.0
HFD2_k127_4230144_2 alcohol dehydrogenase K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000003353 270.0
HFD2_k127_4230144_3 Psort location Cytoplasmic, score K00008,K00060 - 1.1.1.103,1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000004003 267.0
HFD2_k127_4230144_4 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000162 247.0
HFD2_k127_4230144_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000001591 209.0
HFD2_k127_4230144_6 Surface antigen variable number - - - 0.00000000000000000000000000000000000000000000000005919 205.0
HFD2_k127_4230144_7 O-Antigen ligase K18814 - - 0.000000000000000000000000000002134 135.0
HFD2_k127_4230144_8 protein conserved in bacteria K09800 - - 0.000000002055 72.0
HFD2_k127_4230144_9 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000007288 61.0
HFD2_k127_4306783_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 581.0
HFD2_k127_4306783_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007235 516.0
HFD2_k127_4306783_2 Adenylate cyclase - - - 0.0000000000000001618 87.0
HFD2_k127_4306783_3 Forkhead associated domain - - - 0.00000003605 63.0
HFD2_k127_4306783_4 Involved in the tonB-independent uptake of proteins - - - 0.0000003397 57.0
HFD2_k127_436196_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 574.0
HFD2_k127_436196_1 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 582.0
HFD2_k127_436196_10 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000001466 151.0
HFD2_k127_436196_11 TPM domain - - - 0.00000000000000000000000000000000007211 143.0
HFD2_k127_436196_12 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.000000000000000000000000000000007332 135.0
HFD2_k127_436196_13 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000001168 118.0
HFD2_k127_436196_14 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000419 104.0
HFD2_k127_436196_16 Phosphoglycerate mutase family K08296 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000005263 95.0
HFD2_k127_436196_17 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000009693 87.0
HFD2_k127_436196_18 Peptidase dimerisation domain - - - 0.000000000005799 81.0
HFD2_k127_436196_19 DNA polymerase III, delta' K02340 - 2.7.7.7 0.0000007639 61.0
HFD2_k127_436196_2 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 398.0
HFD2_k127_436196_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 376.0
HFD2_k127_436196_4 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 308.0
HFD2_k127_436196_5 COGs COG5616 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005863 271.0
HFD2_k127_436196_6 PFAM LemA family protein K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009997 251.0
HFD2_k127_436196_7 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000001109 232.0
HFD2_k127_436196_8 response regulator K10943 - - 0.0000000000000000000000000000000000000000000000000000000000000008006 237.0
HFD2_k127_436196_9 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000006581 188.0
HFD2_k127_4401399_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.38e-286 903.0
HFD2_k127_4401399_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 5.001e-274 864.0
HFD2_k127_4401399_10 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 443.0
HFD2_k127_4401399_11 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 442.0
HFD2_k127_4401399_12 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 417.0
HFD2_k127_4401399_13 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 402.0
HFD2_k127_4401399_14 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 409.0
HFD2_k127_4401399_15 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008795 382.0
HFD2_k127_4401399_16 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 323.0
HFD2_k127_4401399_17 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 325.0
HFD2_k127_4401399_18 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 308.0
HFD2_k127_4401399_19 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 307.0
HFD2_k127_4401399_2 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 3.895e-251 793.0
HFD2_k127_4401399_20 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001143 286.0
HFD2_k127_4401399_21 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002932 268.0
HFD2_k127_4401399_22 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001531 260.0
HFD2_k127_4401399_23 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000003489 267.0
HFD2_k127_4401399_24 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000825 269.0
HFD2_k127_4401399_25 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000002274 248.0
HFD2_k127_4401399_26 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000000000000000004315 226.0
HFD2_k127_4401399_27 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000000000000000000001303 213.0
HFD2_k127_4401399_28 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000002884 225.0
HFD2_k127_4401399_29 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000001045 215.0
HFD2_k127_4401399_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.087e-229 719.0
HFD2_k127_4401399_30 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000939 196.0
HFD2_k127_4401399_31 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000001926 198.0
HFD2_k127_4401399_32 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000004934 151.0
HFD2_k127_4401399_33 ggdef domain - - - 0.00000000000000000000000000000000002039 151.0
HFD2_k127_4401399_34 PFAM Lipid A Biosynthesis N-terminal - - - 0.00000000000000000000000000000000003322 136.0
HFD2_k127_4401399_35 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000002682 143.0
HFD2_k127_4401399_36 thyroxine 5'-deiodinase activity K01562 GO:0003674,GO:0003824,GO:0004800,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006575,GO:0006590,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008430,GO:0009987,GO:0010817,GO:0016020,GO:0016491,GO:0018958,GO:0042403,GO:0042445,GO:0044237,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901360,GO:1901564,GO:1901615 1.21.99.4 0.00000000000000000000000000008182 120.0
HFD2_k127_4401399_37 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000007612 105.0
HFD2_k127_4401399_38 Polymer-forming cytoskeletal - - - 0.0000000000000000000001208 103.0
HFD2_k127_4401399_39 signal transduction histidine kinase K07642 - 2.7.13.3 0.0000000000000000000003682 110.0
HFD2_k127_4401399_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 1.284e-226 712.0
HFD2_k127_4401399_40 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000001584 102.0
HFD2_k127_4401399_41 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000002289 100.0
HFD2_k127_4401399_43 helix_turn_helix, mercury resistance - - - 0.0000000000000000004774 94.0
HFD2_k127_4401399_44 toxin-antitoxin pair type II binding - - - 0.000000000000000001345 89.0
HFD2_k127_4401399_45 Putative single-stranded nucleic acids-binding domain K06346 - - 0.00000000000000004413 96.0
HFD2_k127_4401399_46 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000001029 85.0
HFD2_k127_4401399_47 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000001386 84.0
HFD2_k127_4401399_48 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000003585 81.0
HFD2_k127_4401399_49 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000001854 81.0
HFD2_k127_4401399_5 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 636.0
HFD2_k127_4401399_50 Ribosomal protein L34 K02914 - - 0.00000000000002548 73.0
HFD2_k127_4401399_51 arylamine N-acetyltransferase activity - - - 0.0000000009736 72.0
HFD2_k127_4401399_52 TPR repeat - - - 0.00000003555 61.0
HFD2_k127_4401399_53 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000001867 63.0
HFD2_k127_4401399_54 polysaccharide deacetylase - - - 0.0000003676 63.0
HFD2_k127_4401399_55 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0002475 49.0
HFD2_k127_4401399_56 - - - - 0.00055 46.0
HFD2_k127_4401399_6 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 627.0
HFD2_k127_4401399_7 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009359 574.0
HFD2_k127_4401399_8 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 493.0
HFD2_k127_4401399_9 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 454.0
HFD2_k127_4436063_0 Glycosyl transferases group 1 - - - 6.799e-203 651.0
HFD2_k127_4436063_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 450.0
HFD2_k127_4436063_10 - - - - 0.00000000000000000001029 108.0
HFD2_k127_4436063_11 Conserved repeat domain - - - 0.000000000000001014 83.0
HFD2_k127_4436063_12 Belongs to the peptidase S8 family - - - 0.00000000000001706 79.0
HFD2_k127_4436063_13 polysaccharide deacetylase K15531 - 3.2.1.156 0.000000000001584 79.0
HFD2_k127_4436063_14 polysaccharide deacetylase - - - 0.00000000001872 77.0
HFD2_k127_4436063_15 D-alanyl-D-alanine carboxypeptidase - - - 0.00000000006776 75.0
HFD2_k127_4436063_2 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005163 364.0
HFD2_k127_4436063_3 Glycosyltransferase like family 2 K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008844 293.0
HFD2_k127_4436063_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000007046 233.0
HFD2_k127_4436063_5 - - - - 0.00000000000000000000000000000000000000000000000000000004651 217.0
HFD2_k127_4436063_6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000002982 182.0
HFD2_k127_4436063_7 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000001681 166.0
HFD2_k127_4436063_8 serine-type endopeptidase activity K20276 - - 0.0000000000000000000000000000000000009385 154.0
HFD2_k127_4436063_9 Methyltransferase domain - - - 0.00000000000000000000000000000001188 141.0
HFD2_k127_4458189_0 COG3005 Nitrate TMAO reductases, membrane-bound tetraheme cytochrome c subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001822 259.0
HFD2_k127_4458189_1 Putative outer membrane beta-barrel porin, MtrB/PioB K22110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001888 273.0
HFD2_k127_4482276_0 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 1.173e-303 947.0
HFD2_k127_4482276_1 PFAM Glycoside hydrolase 15-related K01178 - 3.2.1.3 7.793e-280 869.0
HFD2_k127_4482276_10 cytochrome oxidase assembly K02259 - - 0.000000001465 64.0
HFD2_k127_4482276_12 - - - - 0.00001476 52.0
HFD2_k127_4482276_2 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 461.0
HFD2_k127_4482276_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000003575 271.0
HFD2_k127_4482276_4 Major facilitator Superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009663 254.0
HFD2_k127_4482276_5 Trehalose-phosphatase K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000001133 218.0
HFD2_k127_4482276_6 Heme copper-type cytochrome quinol oxidase, subunit K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000001655 169.0
HFD2_k127_4482276_7 Protein of unknown function (DUF420) K08976 - - 0.0000000000000000000000000000000000000002686 153.0
HFD2_k127_4482276_8 Domain of unknown function (DUF374) K02527,K09778 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000006497 148.0
HFD2_k127_4482276_9 hydroperoxide reductase activity - - - 0.0000000000000000001271 103.0
HFD2_k127_4511720_0 Peptidase S46 - - - 3.081e-214 688.0
HFD2_k127_4511720_1 Aldo/keto reductase family K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 488.0
HFD2_k127_4511720_10 Alpha/beta hydrolase family K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001313 244.0
HFD2_k127_4511720_11 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000005988 243.0
HFD2_k127_4511720_12 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000000005592 228.0
HFD2_k127_4511720_13 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000000000000175 206.0
HFD2_k127_4511720_14 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000002157 198.0
HFD2_k127_4511720_15 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000444 205.0
HFD2_k127_4511720_16 response to oxidative stress K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.000000000000000000000000000000000000000000000000000001275 201.0
HFD2_k127_4511720_17 Transcriptional regulator K13653 - - 0.0000000000000000000000000000000000000000000000001137 183.0
HFD2_k127_4511720_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000008735 182.0
HFD2_k127_4511720_19 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000008621 179.0
HFD2_k127_4511720_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 452.0
HFD2_k127_4511720_20 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000000002024 165.0
HFD2_k127_4511720_21 Putative heavy-metal-binding - - - 0.000000000000000000000000000000000000000007344 156.0
HFD2_k127_4511720_22 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000005008 168.0
HFD2_k127_4511720_23 - - - - 0.00000000000000000000000001277 120.0
HFD2_k127_4511720_24 - - - - 0.00000000000000000000000003343 111.0
HFD2_k127_4511720_26 - - - - 0.00000000000000000002542 101.0
HFD2_k127_4511720_27 SnoaL-like domain - - - 0.00000000000000007851 91.0
HFD2_k127_4511720_28 Peptide methionine sulfoxide reductase K07304,K12267 - 1.8.4.11,1.8.4.12 0.000000000000001242 76.0
HFD2_k127_4511720_29 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000008269 86.0
HFD2_k127_4511720_3 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007791 397.0
HFD2_k127_4511720_30 Trypsin K04771 - 3.4.21.107 0.0000000000001012 80.0
HFD2_k127_4511720_31 Acetyltransferase (GNAT) domain - - - 0.000000000001937 69.0
HFD2_k127_4511720_32 - - - - 0.0000000003559 61.0
HFD2_k127_4511720_33 Bacterial membrane protein, YfhO - - - 0.00000009678 65.0
HFD2_k127_4511720_34 - - - - 0.000001576 51.0
HFD2_k127_4511720_36 Cytochrome c - - - 0.0000111 58.0
HFD2_k127_4511720_37 LysE type translocator - - - 0.0001034 49.0
HFD2_k127_4511720_4 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 375.0
HFD2_k127_4511720_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 379.0
HFD2_k127_4511720_6 Phenazine biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 350.0
HFD2_k127_4511720_7 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007088 332.0
HFD2_k127_4511720_8 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 319.0
HFD2_k127_4511720_9 Mo-co oxidoreductase dimerisation domain K00387 - 1.8.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 325.0
HFD2_k127_4521600_0 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006783 274.0
HFD2_k127_4521600_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000004145 262.0
HFD2_k127_4521600_10 SprT-like family - - - 0.00004878 52.0
HFD2_k127_4521600_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001329 263.0
HFD2_k127_4521600_3 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000005934 204.0
HFD2_k127_4521600_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000003762 207.0
HFD2_k127_4521600_5 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.00000000000000000000000000000000000000000000001476 179.0
HFD2_k127_4521600_6 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000001571 141.0
HFD2_k127_4521600_7 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000006929 90.0
HFD2_k127_4521600_8 Adenylate cyclase - - - 0.000000000000005584 83.0
HFD2_k127_4521600_9 Forkhead associated domain - - - 0.0000000004397 68.0
HFD2_k127_4540785_0 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 561.0
HFD2_k127_4540785_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 514.0
HFD2_k127_4540785_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000008788 220.0
HFD2_k127_4540785_4 - - - - 0.000001302 55.0
HFD2_k127_4540785_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000004217 51.0
HFD2_k127_4543036_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 4.899e-199 636.0
HFD2_k127_4543036_1 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 559.0
HFD2_k127_4543036_10 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.000000000000000000000000002029 120.0
HFD2_k127_4543036_11 PFAM molybdopterin biosynthesis MoaE protein K03635,K21142 - 2.8.1.12 0.0000000000000184 76.0
HFD2_k127_4543036_12 Psort location CytoplasmicMembrane, score - - - 0.0000000000000508 86.0
HFD2_k127_4543036_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K00945,K02945,K03527 - 1.17.7.4,2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 374.0
HFD2_k127_4543036_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 368.0
HFD2_k127_4543036_4 short-chain dehydrogenase K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009689 293.0
HFD2_k127_4543036_5 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000003025 222.0
HFD2_k127_4543036_6 Enoyl-(Acyl carrier protein) reductase K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000004904 202.0
HFD2_k127_4543036_7 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000227 154.0
HFD2_k127_4543036_8 Dioxygenase K03381 - 1.13.11.1 0.0000000000000000000000000000000000003801 147.0
HFD2_k127_4543036_9 - - - - 0.0000000000000000000000000000000005312 134.0
HFD2_k127_454879_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 4.76e-296 933.0
HFD2_k127_454879_1 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 3.853e-245 768.0
HFD2_k127_454879_10 - - - - 0.00000000000000000000000000000000000000000000001058 177.0
HFD2_k127_454879_11 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000004684 163.0
HFD2_k127_454879_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000008091 162.0
HFD2_k127_454879_13 Crp-like helix-turn-helix domain K10914 - - 0.00000000000000000000000000000000005027 150.0
HFD2_k127_454879_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000004379 120.0
HFD2_k127_454879_15 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000004062 110.0
HFD2_k127_454879_16 Belongs to the aldehyde dehydrogenase family K22187 - - 0.00000000000000000004518 98.0
HFD2_k127_454879_17 Pfam:CPSase_L_chain K01968,K13777 - 6.4.1.4,6.4.1.5 0.0000000000000001919 94.0
HFD2_k127_454879_18 Thiamine-binding protein - - - 0.0000000000000007282 83.0
HFD2_k127_454879_19 outer membrane autotransporter barrel domain protein - - - 0.0000000000001618 79.0
HFD2_k127_454879_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 491.0
HFD2_k127_454879_20 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000002812 73.0
HFD2_k127_454879_21 Glutaredoxin-like domain (DUF836) - - - 0.0000000003003 71.0
HFD2_k127_454879_22 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000004902 68.0
HFD2_k127_454879_25 energy transducer activity K03832 - - 0.000005778 50.0
HFD2_k127_454879_26 COG0457 FOG TPR repeat - - - 0.0001209 55.0
HFD2_k127_454879_3 Aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 370.0
HFD2_k127_454879_4 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 357.0
HFD2_k127_454879_5 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000001286 284.0
HFD2_k127_454879_6 enoyl-CoA hydratase K13766,K13779 - 4.2.1.18,4.2.1.57 0.0000000000000000000000000000000000000000000000000000000000000000007721 249.0
HFD2_k127_454879_7 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000000006141 231.0
HFD2_k127_454879_8 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000009248 218.0
HFD2_k127_454879_9 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000001497 205.0
HFD2_k127_4554247_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.587e-194 638.0
HFD2_k127_4554247_1 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000004124 169.0
HFD2_k127_4554247_2 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000005084 85.0
HFD2_k127_4560494_0 Sodium/hydrogen exchanger family K03455,K11747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 379.0
HFD2_k127_4560494_1 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000007125 243.0
HFD2_k127_4560494_2 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000001417 247.0
HFD2_k127_4560494_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000002573 197.0
HFD2_k127_4560494_4 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000000003262 160.0
HFD2_k127_4560494_5 DoxX K15977 - - 0.000000000000000000000000000000001007 143.0
HFD2_k127_4560494_6 SNARE associated Golgi protein - - - 0.0000000000000000000000000000001168 139.0
HFD2_k127_4560494_7 SnoaL-like domain - - - 0.00000000000000000000001788 106.0
HFD2_k127_4560494_9 TonB dependent receptor - - - 0.000001155 57.0
HFD2_k127_4570716_0 metallopeptidase activity K01993,K13408,K16922 - - 0.000000000000000000000000000000000000000000000000000000000000006503 243.0
HFD2_k127_4570716_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.000000000000000000000000000000000000000000000004306 197.0
HFD2_k127_4570716_2 Bacterial regulatory protein, Fis family K07713 - - 0.00000000000000000001554 95.0
HFD2_k127_4570716_3 STAS domain K04749 - - 0.0000000000000617 78.0
HFD2_k127_4573456_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 6.104e-206 648.0
HFD2_k127_4573456_1 NapC/NirT cytochrome c family, N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 578.0
HFD2_k127_4573456_10 - - - - 0.000000000002568 80.0
HFD2_k127_4573456_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 463.0
HFD2_k127_4573456_3 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 413.0
HFD2_k127_4573456_4 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 382.0
HFD2_k127_4573456_5 formate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 360.0
HFD2_k127_4573456_6 Major Facilitator Superfamily K08177 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001305 292.0
HFD2_k127_4573456_7 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000005249 257.0
HFD2_k127_4573456_8 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000000000000005296 239.0
HFD2_k127_4573456_9 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.0000000000000000000000000000000000000000004143 162.0
HFD2_k127_4600950_0 4Fe-4S dicluster domain - - - 0.0 1193.0
HFD2_k127_4600950_1 4Fe-4S dicluster domain K00184 - - 0.0 1070.0
HFD2_k127_4600950_2 Polysulphide reductase, NrfD K00185 - - 2.378e-209 696.0
HFD2_k127_4600950_3 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 451.0
HFD2_k127_4600950_4 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 339.0
HFD2_k127_4600950_5 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 325.0
HFD2_k127_4600950_6 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009432 256.0
HFD2_k127_4600950_7 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000000000000000000125 241.0
HFD2_k127_4600950_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000001372 210.0
HFD2_k127_4600950_9 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000002399 190.0
HFD2_k127_4620525_0 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 416.0
HFD2_k127_4620525_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009315 299.0
HFD2_k127_4620525_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001645 271.0
HFD2_k127_4620525_3 Polymorphic membrane protein Chlamydia - - - 0.000000000000000000000000000004316 123.0
HFD2_k127_4620525_4 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000005088 97.0
HFD2_k127_4657885_0 Protein kinase domain K12132 - 2.7.11.1 2.468e-243 780.0
HFD2_k127_4657885_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.263e-219 711.0
HFD2_k127_4657885_2 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000008109 117.0
HFD2_k127_4657885_3 PIN domain - - - 0.0000000000001741 78.0
HFD2_k127_4670828_0 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 506.0
HFD2_k127_4670828_1 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 458.0
HFD2_k127_4670828_10 Domain of unknown function (DUF4437) - - - 0.00000000000000000000000000000000000000001195 158.0
HFD2_k127_4670828_11 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000005904 147.0
HFD2_k127_4670828_12 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000296 134.0
HFD2_k127_4670828_13 Sporulation and spore germination - - - 0.000000000000001236 85.0
HFD2_k127_4670828_14 Necessary for normal cell division and for the maintenance of normal septation - - - 0.00000000000001655 84.0
HFD2_k127_4670828_15 PIN domain - - - 0.0000000000003489 76.0
HFD2_k127_4670828_16 SnoaL-like domain - - - 0.000000001235 61.0
HFD2_k127_4670828_17 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000001201 57.0
HFD2_k127_4670828_19 AbrB family - - - 0.0001065 48.0
HFD2_k127_4670828_2 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 390.0
HFD2_k127_4670828_3 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 372.0
HFD2_k127_4670828_4 Thermophilic metalloprotease (M29) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 374.0
HFD2_k127_4670828_5 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 294.0
HFD2_k127_4670828_6 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000006795 232.0
HFD2_k127_4670828_7 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000002245 201.0
HFD2_k127_4670828_8 ATPase. Has a role at an early stage in the morphogenesis of the spore coat - - - 0.000000000000000000000000000000000000000000000000002445 204.0
HFD2_k127_4670828_9 - - - - 0.000000000000000000000000000000000000000004153 162.0
HFD2_k127_4677173_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1081.0
HFD2_k127_4677173_1 Domain of unknown function (DUF3520) K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 473.0
HFD2_k127_4677173_10 Metallo-beta-lactamase superfamily - - - 0.00000000000000000003025 105.0
HFD2_k127_4677173_11 - - - - 0.00000000001862 70.0
HFD2_k127_4677173_12 YXWGXW repeat (2 copies) - - - 0.00000000003807 70.0
HFD2_k127_4677173_13 - K20326 - - 0.00000002276 65.0
HFD2_k127_4677173_14 NHL repeat - - - 0.000002095 59.0
HFD2_k127_4677173_2 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 365.0
HFD2_k127_4677173_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000001105 259.0
HFD2_k127_4677173_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001942 252.0
HFD2_k127_4677173_5 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000003855 227.0
HFD2_k127_4677173_6 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000000000000000000000000003629 211.0
HFD2_k127_4677173_7 diguanylate cyclase - - - 0.0000000000000000000000000000000000024 149.0
HFD2_k127_4677173_8 - - - - 0.00000000000000000000004076 102.0
HFD2_k127_4677173_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000001368 106.0
HFD2_k127_4677336_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 578.0
HFD2_k127_4677336_1 Beta-Casp domain K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 456.0
HFD2_k127_4677336_10 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000001279 186.0
HFD2_k127_4677336_11 isomerase activity K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000003239 190.0
HFD2_k127_4677336_12 Beta-lactamase - - - 0.0000000000000000000000000000000000000003193 165.0
HFD2_k127_4677336_13 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000007314 156.0
HFD2_k127_4677336_14 PhoQ Sensor K01768,K04769,K10914 - 4.6.1.1 0.000000000000000000000003942 119.0
HFD2_k127_4677336_15 UPF0761 membrane protein K07058 - - 0.00000000000000000008514 102.0
HFD2_k127_4677336_16 - - - - 0.000000000000007241 79.0
HFD2_k127_4677336_17 - - - - 0.0000001273 59.0
HFD2_k127_4677336_18 - - - - 0.00002599 49.0
HFD2_k127_4677336_2 Dihydroxyacetone kinase family K07030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 434.0
HFD2_k127_4677336_3 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 430.0
HFD2_k127_4677336_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 408.0
HFD2_k127_4677336_5 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 303.0
HFD2_k127_4677336_6 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 301.0
HFD2_k127_4677336_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 297.0
HFD2_k127_4677336_8 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000000000000000000000000000000007258 221.0
HFD2_k127_4677336_9 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000002835 212.0
HFD2_k127_4720962_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.051e-251 805.0
HFD2_k127_4720962_1 Cobalamin-independent synthase, Catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 492.0
HFD2_k127_4720962_2 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009647 411.0
HFD2_k127_4720962_3 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009855 385.0
HFD2_k127_4720962_4 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000002539 179.0
HFD2_k127_4720962_5 4Fe-4S binding domain - - - 0.0000000000000000000000000002917 119.0
HFD2_k127_4720962_6 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000007842 69.0
HFD2_k127_4720962_7 ASPIC and UnbV - - - 0.00000003393 57.0
HFD2_k127_4811478_0 domain, Protein K01212,K12287,K20276 - 3.2.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 326.0
HFD2_k127_4811478_1 Two component transcriptional regulator, LuxR family - - - 0.000000000000000000002387 106.0
HFD2_k127_4811478_2 Protein of unknown function (DUF2442) - - - 0.000000000000002448 85.0
HFD2_k127_4811478_3 - - - - 0.00001374 53.0
HFD2_k127_4811478_4 - - - - 0.0000262 57.0
HFD2_k127_4811478_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008784,GO:0009058,GO:0009059,GO:0009078,GO:0009079,GO:0009252,GO:0009273,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0030170,GO:0030203,GO:0030632,GO:0034645,GO:0036094,GO:0036361,GO:0040007,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.1 0.0001929 48.0
HFD2_k127_4827196_0 malic protein domain protein K00029 - 1.1.1.40 3.449e-294 922.0
HFD2_k127_4827196_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 600.0
HFD2_k127_4827196_2 Domain of unknown function (DUF4412) - - - 0.0009174 44.0
HFD2_k127_4855544_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.858e-288 900.0
HFD2_k127_4855544_1 Protein kinase domain K12132 - 2.7.11.1 8.49e-234 755.0
HFD2_k127_4855544_10 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 442.0
HFD2_k127_4855544_11 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 401.0
HFD2_k127_4855544_12 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009781 373.0
HFD2_k127_4855544_13 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 364.0
HFD2_k127_4855544_14 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 380.0
HFD2_k127_4855544_15 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 315.0
HFD2_k127_4855544_16 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 295.0
HFD2_k127_4855544_17 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000629 291.0
HFD2_k127_4855544_18 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002332 293.0
HFD2_k127_4855544_19 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003219 276.0
HFD2_k127_4855544_2 elongation factor G K02355 - - 4.3e-209 671.0
HFD2_k127_4855544_20 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000008285 284.0
HFD2_k127_4855544_21 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000001471 248.0
HFD2_k127_4855544_22 PFAM peptidase M24 K01262,K01271,K01274 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000002971 242.0
HFD2_k127_4855544_23 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000001857 208.0
HFD2_k127_4855544_24 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001981 207.0
HFD2_k127_4855544_25 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000007344 209.0
HFD2_k127_4855544_26 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000002079 200.0
HFD2_k127_4855544_27 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000002527 212.0
HFD2_k127_4855544_28 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000001418 183.0
HFD2_k127_4855544_29 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000005641 177.0
HFD2_k127_4855544_3 Involved in the tonB-independent uptake of proteins - - - 1.009e-200 657.0
HFD2_k127_4855544_30 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000008042 154.0
HFD2_k127_4855544_31 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000002074 158.0
HFD2_k127_4855544_32 structural constituent of ribosome K02879 - - 0.00000000000000000000000000000000009467 141.0
HFD2_k127_4855544_33 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000001573 135.0
HFD2_k127_4855544_34 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000001163 141.0
HFD2_k127_4855544_35 PFAM Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.000000000000000000000000000003068 140.0
HFD2_k127_4855544_36 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000002016 114.0
HFD2_k127_4855544_37 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000003927 115.0
HFD2_k127_4855544_38 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000003948 85.0
HFD2_k127_4855544_39 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000001872 67.0
HFD2_k127_4855544_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009585 585.0
HFD2_k127_4855544_40 50S ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000003956 64.0
HFD2_k127_4855544_41 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00001617 55.0
HFD2_k127_4855544_42 PFAM VanZ like family - - - 0.00002081 56.0
HFD2_k127_4855544_5 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 559.0
HFD2_k127_4855544_6 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 522.0
HFD2_k127_4855544_7 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 497.0
HFD2_k127_4855544_8 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 446.0
HFD2_k127_4855544_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 435.0
HFD2_k127_4857389_0 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 601.0
HFD2_k127_4857389_1 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 466.0
HFD2_k127_4857389_10 helix_turn_helix, cAMP Regulatory protein K21564 - - 0.000000000000000000000000000001021 130.0
HFD2_k127_4857389_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000001044 117.0
HFD2_k127_4857389_12 PFAM cytochrome c class III - - - 0.000000000000000000000002836 111.0
HFD2_k127_4857389_13 Di-iron-containing protein involved in the repair of iron-sulfur clusters - - - 0.000000000000000001107 98.0
HFD2_k127_4857389_14 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000001156 99.0
HFD2_k127_4857389_2 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 411.0
HFD2_k127_4857389_3 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 379.0
HFD2_k127_4857389_4 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 337.0
HFD2_k127_4857389_5 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 329.0
HFD2_k127_4857389_6 Cytochrome c K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006784 302.0
HFD2_k127_4857389_7 Cytochrome c K00413 - - 0.000000000000000000000000000000000000000000000000000000001531 223.0
HFD2_k127_4857389_8 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000000007418 165.0
HFD2_k127_4857389_9 to Cytochrome c-554 precursor (C554) (Hydroxylamine oxidoreductase-linked cytochrome) pir A59036 cytochrome c554, tetraheme, precursor - Nitrosomonas europaea - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000009947 129.0
HFD2_k127_4859966_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 5.748e-201 634.0
HFD2_k127_4859966_1 epoxide hydrolase K01253 - 3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 484.0
HFD2_k127_4859966_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 322.0
HFD2_k127_4859966_3 Esterase PHB depolymerase - - - 0.000000000000000000000000000000000000000000000001818 184.0
HFD2_k127_4859966_4 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000003758 160.0
HFD2_k127_4859966_5 glycolate biosynthetic process K01091,K06019,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18,3.6.1.1 0.000000000000000000000000000000000000003031 156.0
HFD2_k127_4859966_6 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000005533 132.0
HFD2_k127_4859966_7 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000001275 92.0
HFD2_k127_4859966_8 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000009085 84.0
HFD2_k127_4859966_9 Prolyl oligopeptidase family - - - 0.00000000000823 67.0
HFD2_k127_4925815_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 419.0
HFD2_k127_4925815_1 Flotillin K07192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 411.0
HFD2_k127_4925815_2 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 385.0
HFD2_k127_4925815_3 PFAM Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 340.0
HFD2_k127_4925815_4 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 343.0
HFD2_k127_4925815_5 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000007048 202.0
HFD2_k127_4925815_6 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000002767 186.0
HFD2_k127_4925815_7 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000004081 118.0
HFD2_k127_4961149_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 5.791e-209 681.0
HFD2_k127_4961149_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 565.0
HFD2_k127_4961149_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 473.0
HFD2_k127_4961149_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 376.0
HFD2_k127_4961149_4 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000002433 138.0
HFD2_k127_4961149_5 - - - - 0.000000000000000000002599 100.0
HFD2_k127_5152229_0 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 326.0
HFD2_k127_5152229_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 304.0
HFD2_k127_5152229_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000001289 226.0
HFD2_k127_5152229_3 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000004517 191.0
HFD2_k127_5152229_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000001634 179.0
HFD2_k127_5152229_5 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000002213 186.0
HFD2_k127_5152229_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000009163 161.0
HFD2_k127_5152229_7 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000001949 132.0
HFD2_k127_5152229_8 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000001248 83.0
HFD2_k127_5321052_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.826e-284 900.0
HFD2_k127_5321052_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006162 420.0
HFD2_k127_5321052_2 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 329.0
HFD2_k127_5321052_3 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 299.0
HFD2_k127_5321052_4 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000005852 253.0
HFD2_k127_5321052_5 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000001435 130.0
HFD2_k127_5321052_6 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.00000000000000000000001333 105.0
HFD2_k127_5321052_7 - - - - 0.0000000000000003054 84.0
HFD2_k127_5408340_0 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 527.0
HFD2_k127_5408340_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 488.0
HFD2_k127_5408340_10 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 355.0
HFD2_k127_5408340_11 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002071 296.0
HFD2_k127_5408340_12 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005758 284.0
HFD2_k127_5408340_13 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001559 280.0
HFD2_k127_5408340_14 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002092 278.0
HFD2_k127_5408340_15 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000032 256.0
HFD2_k127_5408340_16 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000001828 265.0
HFD2_k127_5408340_17 DNA ligase N terminus - - - 0.0000000000000000000000000000000000000000000000000000000000002311 231.0
HFD2_k127_5408340_18 hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000008136 222.0
HFD2_k127_5408340_19 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000006302 176.0
HFD2_k127_5408340_2 DEAD DEAH box K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 460.0
HFD2_k127_5408340_20 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000003736 160.0
HFD2_k127_5408340_21 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000001932 145.0
HFD2_k127_5408340_22 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000002509 132.0
HFD2_k127_5408340_23 Tetratricopeptide repeat - - - 0.00000000000000000000000003183 125.0
HFD2_k127_5408340_25 PFAM FecR protein - - - 0.000000000000000006391 97.0
HFD2_k127_5408340_26 Cell shape-determining protein MreC K03570 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963 - 0.00000000000000001503 93.0
HFD2_k127_5408340_27 fatty acid desaturase - - - 0.00000000000000809 86.0
HFD2_k127_5408340_28 Hep Hag repeat protein K07278,K21449 - - 0.00000000000007097 73.0
HFD2_k127_5408340_29 Belongs to the UPF0312 family - - - 0.0000000000002301 79.0
HFD2_k127_5408340_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 446.0
HFD2_k127_5408340_30 - - - - 0.00002077 52.0
HFD2_k127_5408340_4 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000531 459.0
HFD2_k127_5408340_5 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 426.0
HFD2_k127_5408340_6 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 410.0
HFD2_k127_5408340_7 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 414.0
HFD2_k127_5408340_8 Acts as a magnesium transporter K04767,K06213,K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 380.0
HFD2_k127_5408340_9 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 375.0
HFD2_k127_5433674_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.183e-261 827.0
HFD2_k127_5433674_1 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 497.0
HFD2_k127_5433674_10 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000002989 193.0
HFD2_k127_5433674_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000003733 189.0
HFD2_k127_5433674_12 Adenosine/AMP deaminase K01488,K18286 GO:0000034,GO:0003674,GO:0003824,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.4.4,3.5.4.40 0.0000000000000000000000000000000000000000004219 171.0
HFD2_k127_5433674_13 peroxiredoxin activity - - - 0.00000000000000000000000000000000000000002937 160.0
HFD2_k127_5433674_14 Belongs to the BshC family K22136 - - 0.000000000000000000000000000000000005743 154.0
HFD2_k127_5433674_15 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000002391 117.0
HFD2_k127_5433674_16 cell redox homeostasis - - - 0.000000000000000000000007685 114.0
HFD2_k127_5433674_17 - - - - 0.0000000000000000000001794 109.0
HFD2_k127_5433674_18 Preprotein translocase SecG subunit K03075 - - 0.00000000000000008951 85.0
HFD2_k127_5433674_19 Haemolytic K08998 - - 0.000000000000001269 82.0
HFD2_k127_5433674_2 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 424.0
HFD2_k127_5433674_21 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000004884 52.0
HFD2_k127_5433674_22 TM2 domain - - - 0.0000355 51.0
HFD2_k127_5433674_23 PFAM Tetratricopeptide repeat - - - 0.0004928 51.0
HFD2_k127_5433674_3 glycosyl transferase group 1 K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005879 410.0
HFD2_k127_5433674_4 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 424.0
HFD2_k127_5433674_5 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 377.0
HFD2_k127_5433674_6 Initiation factor 2 subunit family K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 360.0
HFD2_k127_5433674_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 304.0
HFD2_k127_5433674_8 PFAM GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000000000000000001665 227.0
HFD2_k127_5433674_9 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000002818 189.0
HFD2_k127_5459764_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004209 286.0
HFD2_k127_5459764_1 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000003155 242.0
HFD2_k127_5459764_2 HlyD family secretion protein K02005 - - 0.00000000000000000000000000000000000000000000000001772 182.0
HFD2_k127_5459764_3 - - - - 0.00000000000000000000000000000000000000003285 164.0
HFD2_k127_5459764_4 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.0000000000000000000002286 98.0
HFD2_k127_5459764_5 Protein of unknown function (DUF2662) - - - 0.000000000004274 74.0
HFD2_k127_5459764_6 Protein kinase domain - - - 0.0000000003083 68.0
HFD2_k127_5459764_7 - - - - 0.0000006247 53.0
HFD2_k127_5486045_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1039.0
HFD2_k127_5486045_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 3.049e-285 907.0
HFD2_k127_5486045_10 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 421.0
HFD2_k127_5486045_100 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000009776 71.0
HFD2_k127_5486045_101 Tetratricopeptide repeats - - - 0.000000002576 72.0
HFD2_k127_5486045_102 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000003033 66.0
HFD2_k127_5486045_103 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.000000004104 62.0
HFD2_k127_5486045_104 unfolded protein binding K06142 - - 0.00000001611 66.0
HFD2_k127_5486045_105 - - - - 0.0000002742 59.0
HFD2_k127_5486045_106 PFAM Transglutaminase-like - - - 0.0000004464 62.0
HFD2_k127_5486045_107 ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import K01338 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006508,GO:0006605,GO:0006625,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0016043,GO:0016485,GO:0019538,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044238,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564 3.4.21.53 0.000003083 60.0
HFD2_k127_5486045_11 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 411.0
HFD2_k127_5486045_12 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 417.0
HFD2_k127_5486045_13 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 385.0
HFD2_k127_5486045_14 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 379.0
HFD2_k127_5486045_15 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 385.0
HFD2_k127_5486045_16 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 371.0
HFD2_k127_5486045_17 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 366.0
HFD2_k127_5486045_18 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 367.0
HFD2_k127_5486045_19 Permease, YjgP YjgQ - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 368.0
HFD2_k127_5486045_2 Belongs to the ClpA ClpB family K03696 - - 3.415e-284 895.0
HFD2_k127_5486045_20 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 355.0
HFD2_k127_5486045_21 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 345.0
HFD2_k127_5486045_22 Surface antigen variable number K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 354.0
HFD2_k127_5486045_23 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 345.0
HFD2_k127_5486045_24 Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 340.0
HFD2_k127_5486045_25 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 334.0
HFD2_k127_5486045_26 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 338.0
HFD2_k127_5486045_27 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 346.0
HFD2_k127_5486045_28 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 323.0
HFD2_k127_5486045_29 PFAM PfkB domain protein K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 327.0
HFD2_k127_5486045_3 Pyridoxal-dependent decarboxylase conserved domain K01593,K01634 - 4.1.1.105,4.1.1.28,4.1.2.27 6.737e-229 721.0
HFD2_k127_5486045_30 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 316.0
HFD2_k127_5486045_31 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 309.0
HFD2_k127_5486045_32 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 322.0
HFD2_k127_5486045_33 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 323.0
HFD2_k127_5486045_34 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009185 321.0
HFD2_k127_5486045_35 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 310.0
HFD2_k127_5486045_36 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 310.0
HFD2_k127_5486045_37 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 300.0
HFD2_k127_5486045_38 PFAM ABC transporter related K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 302.0
HFD2_k127_5486045_39 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 318.0
HFD2_k127_5486045_4 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000043 590.0
HFD2_k127_5486045_40 Protein of unknown function (DUF1684) K09164 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 295.0
HFD2_k127_5486045_41 ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009183 284.0
HFD2_k127_5486045_42 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000136 301.0
HFD2_k127_5486045_43 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000193 287.0
HFD2_k127_5486045_44 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001617 280.0
HFD2_k127_5486045_45 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002416 286.0
HFD2_k127_5486045_46 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005024 275.0
HFD2_k127_5486045_47 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003704 277.0
HFD2_k127_5486045_48 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000235 263.0
HFD2_k127_5486045_49 Pfam Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002514 275.0
HFD2_k127_5486045_5 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 583.0
HFD2_k127_5486045_50 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000000007532 271.0
HFD2_k127_5486045_51 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004691 266.0
HFD2_k127_5486045_52 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000001211 258.0
HFD2_k127_5486045_53 SpoIVB peptidase S55 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000167 257.0
HFD2_k127_5486045_54 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000109 248.0
HFD2_k127_5486045_55 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000494 233.0
HFD2_k127_5486045_56 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000002838 225.0
HFD2_k127_5486045_57 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000001532 210.0
HFD2_k127_5486045_58 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000001081 225.0
HFD2_k127_5486045_59 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000009195 224.0
HFD2_k127_5486045_6 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 540.0
HFD2_k127_5486045_60 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000001573 208.0
HFD2_k127_5486045_61 CBS domain containing protein K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000004974 211.0
HFD2_k127_5486045_62 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000002115 216.0
HFD2_k127_5486045_63 aminopeptidase activity K07004 - - 0.0000000000000000000000000000000000000000000000000000006146 217.0
HFD2_k127_5486045_64 chromosome segregation K03497 - - 0.000000000000000000000000000000000000000000000000000005363 201.0
HFD2_k127_5486045_65 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372,K16363 - 3.5.1.108,4.2.1.59 0.00000000000000000000000000000000000000000000000001033 189.0
HFD2_k127_5486045_66 PFAM response regulator receiver, regulatory protein LuxR - - - 0.00000000000000000000000000000000000000000000000001646 202.0
HFD2_k127_5486045_67 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000001899 188.0
HFD2_k127_5486045_68 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000002719 170.0
HFD2_k127_5486045_69 NUDIX domain - - - 0.00000000000000000000000000000000000000005144 158.0
HFD2_k127_5486045_7 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 523.0
HFD2_k127_5486045_70 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000000002283 170.0
HFD2_k127_5486045_71 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000007143 155.0
HFD2_k127_5486045_72 PAP2 superfamily - - - 0.000000000000000000000000000000000000006699 156.0
HFD2_k127_5486045_73 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000000000102 152.0
HFD2_k127_5486045_74 AMMECR1 K09141 - - 0.00000000000000000000000000000000000001931 156.0
HFD2_k127_5486045_75 - K07018 - - 0.000000000000000000000000000000000000127 153.0
HFD2_k127_5486045_76 Pfam Response regulator receiver - - - 0.000000000000000000000000000000000001996 153.0
HFD2_k127_5486045_77 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000001258 149.0
HFD2_k127_5486045_78 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000003705 139.0
HFD2_k127_5486045_79 Transglycosylase SLT domain - - - 0.00000000000000000000000000000001623 139.0
HFD2_k127_5486045_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 498.0
HFD2_k127_5486045_80 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000007559 136.0
HFD2_k127_5486045_81 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000002184 127.0
HFD2_k127_5486045_82 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000002486 132.0
HFD2_k127_5486045_83 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.000000000000000000000000000004027 130.0
HFD2_k127_5486045_84 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000004451 128.0
HFD2_k127_5486045_85 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.000000000000000000000000000021 123.0
HFD2_k127_5486045_86 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000009357 121.0
HFD2_k127_5486045_87 Outer membrane lipoprotein - - - 0.0000000000000000000000000005396 126.0
HFD2_k127_5486045_88 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000001209 130.0
HFD2_k127_5486045_89 PFAM PTS system fructose subfamily IIA component K02793 - 2.7.1.191 0.00000000000000000000000001414 118.0
HFD2_k127_5486045_9 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 437.0
HFD2_k127_5486045_90 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000002986 119.0
HFD2_k127_5486045_91 phosphocarrier protein HPr K11189 - - 0.00000000000000000000001729 109.0
HFD2_k127_5486045_92 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000006032 106.0
HFD2_k127_5486045_93 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.0000000000000000000004225 108.0
HFD2_k127_5486045_94 lipopolysaccharide transport K09774 - - 0.0000000000000000000004707 112.0
HFD2_k127_5486045_95 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000002884 92.0
HFD2_k127_5486045_96 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000002348 93.0
HFD2_k127_5486045_97 TonB C terminal K03646,K03832 - - 0.0000000000000003659 88.0
HFD2_k127_5486045_98 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000003187 78.0
HFD2_k127_5486045_99 protein conserved in bacteria - - - 0.000000000007691 73.0
HFD2_k127_5518827_0 Putative outer membrane beta-barrel porin, MtrB/PioB K22110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001325 286.0
HFD2_k127_5518827_1 PFAM Doubled CXXCH motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001949 257.0
HFD2_k127_5518827_2 denitrification pathway - - - 0.000000000000000000000000005332 119.0
HFD2_k127_5525279_0 class II (D K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 556.0
HFD2_k127_5525279_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 522.0
HFD2_k127_5525279_10 PFAM outer membrane efflux protein - - - 0.0000000000000000000000002532 115.0
HFD2_k127_5525279_11 Yip1 domain - - - 0.0000000000000004378 89.0
HFD2_k127_5525279_12 Domain of unknown function (DUF296) K06934 - - 0.000000000000001364 91.0
HFD2_k127_5525279_13 toxin-antitoxin pair type II binding - - - 0.00000003044 67.0
HFD2_k127_5525279_14 gluconolactonase activity K01448,K02395,K08651 - 3.4.21.66,3.5.1.28 0.000000167 65.0
HFD2_k127_5525279_2 Ornithine cyclodeaminase/mu-crystallin family K01750,K18258,K19244 - 1.4.1.1,1.5.1.25,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006528 391.0
HFD2_k127_5525279_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 376.0
HFD2_k127_5525279_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 325.0
HFD2_k127_5525279_5 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 300.0
HFD2_k127_5525279_6 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000002201 168.0
HFD2_k127_5525279_7 manganese ion transmembrane transporter activity - - - 0.0000000000000000000000000000000000005008 162.0
HFD2_k127_5525279_8 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000002562 141.0
HFD2_k127_5525279_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000001411 127.0
HFD2_k127_5579409_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 302.0
HFD2_k127_5579409_1 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000001276 151.0
HFD2_k127_5579409_2 Glycosyl Transferase - - - 0.0000000000000000000000000000000000003699 156.0
HFD2_k127_5579409_3 COG3666 Transposase and inactivated derivatives - - - 0.000000000008344 67.0
HFD2_k127_5579409_4 Glycosyltransferase, group 2 family protein - - - 0.00000000003206 72.0
HFD2_k127_5579409_5 Protein of unknown function, DUF547 - - - 0.000003041 56.0
HFD2_k127_5579409_6 ubiE/COQ5 methyltransferase family - - - 0.0000161 54.0
HFD2_k127_5579409_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000145 55.0
HFD2_k127_5587740_0 PFAM Protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000009697 207.0
HFD2_k127_5587740_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000001696 189.0
HFD2_k127_5587740_2 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000004242 164.0
HFD2_k127_5587740_3 Transcriptional regulator - - - 0.000000000000000000000000000001545 143.0
HFD2_k127_5587740_4 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000002667 91.0
HFD2_k127_5592740_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 3.987e-308 957.0
HFD2_k127_5592740_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 460.0
HFD2_k127_5592740_2 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 281.0
HFD2_k127_5592740_3 ATP-binding region ATPase domain protein - - - 0.0000000000000000849 89.0
HFD2_k127_5592740_4 Helix-turn-helix domain - - - 0.00000008862 59.0
HFD2_k127_5646942_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000582 207.0
HFD2_k127_5646942_1 Methyltransferase domain - - - 0.0000000000000000000000000000001339 137.0
HFD2_k127_5646942_2 - - - - 0.000000000007998 78.0
HFD2_k127_5646942_3 Belongs to the glycosyl hydrolase family 6 - - - 0.0000001555 64.0
HFD2_k127_5648994_0 Glycosyl transferases group 1 - - - 4.548e-206 664.0
HFD2_k127_5648994_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 399.0
HFD2_k127_5648994_10 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000001089 111.0
HFD2_k127_5648994_11 - - - - 0.0000000000000000000999 105.0
HFD2_k127_5648994_12 amine dehydrogenase activity - - - 0.000000000000008559 79.0
HFD2_k127_5648994_13 polysaccharide deacetylase - - - 0.0000000000107 78.0
HFD2_k127_5648994_14 Glycosyl transferases group 1 - - - 0.00000006283 61.0
HFD2_k127_5648994_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 310.0
HFD2_k127_5648994_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001588 241.0
HFD2_k127_5648994_4 Predicted membrane protein (DUF2079) - - - 0.000000000000000000000000000000000000000000000000000000005961 218.0
HFD2_k127_5648994_5 Glycosyltransferase like family K20444 - - 0.000000000000000000000000000000000000000000000001003 194.0
HFD2_k127_5648994_6 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000004997 162.0
HFD2_k127_5648994_7 Methyltransferase domain - - - 0.000000000000000000000000000000000269 145.0
HFD2_k127_5648994_8 Methyltransferase domain - - - 0.00000000000000000000000000002086 134.0
HFD2_k127_5648994_9 RmlD substrate binding domain - - - 0.0000000000000000000000000001963 134.0
HFD2_k127_5724279_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 562.0
HFD2_k127_5724279_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 479.0
HFD2_k127_5724279_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000007143 164.0
HFD2_k127_5724279_3 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000005414 157.0
HFD2_k127_5724279_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000418 121.0
HFD2_k127_5737552_0 Protein kinase domain K12132 - 2.7.11.1 5.992e-246 788.0
HFD2_k127_5737552_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000001226 206.0
HFD2_k127_5737552_2 DinB family - - - 0.0003927 49.0
HFD2_k127_5742782_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1287.0
HFD2_k127_5742782_1 POT family K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 566.0
HFD2_k127_5742782_10 Hep Hag repeat protein - GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000002648 209.0
HFD2_k127_5742782_11 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000308 154.0
HFD2_k127_5742782_12 Tfp pilus assembly protein tip-associated adhesin PilY1 K02674 - - 0.0000000000000000000000000000001414 145.0
HFD2_k127_5742782_13 cytochrome C assembly protein - - - 0.000000000000008114 85.0
HFD2_k127_5742782_14 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.00000000000007788 81.0
HFD2_k127_5742782_15 Iron-sulfur cluster-binding domain - - - 0.0000000000008271 77.0
HFD2_k127_5742782_16 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.00001221 55.0
HFD2_k127_5742782_17 pilus assembly protein PilW K02672 - - 0.00002062 57.0
HFD2_k127_5742782_18 Prokaryotic N-terminal methylation motif K02650 - - 0.0003895 51.0
HFD2_k127_5742782_2 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 494.0
HFD2_k127_5742782_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 446.0
HFD2_k127_5742782_4 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 427.0
HFD2_k127_5742782_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 301.0
HFD2_k127_5742782_6 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 296.0
HFD2_k127_5742782_7 NmrA-like family K19267 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 287.0
HFD2_k127_5742782_8 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003462 295.0
HFD2_k127_5742782_9 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000001013 253.0
HFD2_k127_5757414_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000008206 261.0
HFD2_k127_5757414_1 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000001634 186.0
HFD2_k127_5757414_2 receptor K16092 - - 0.0000000000000000000000000000000000000000000001103 191.0
HFD2_k127_5821318_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 511.0
HFD2_k127_5821318_1 response regulator K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 460.0
HFD2_k127_5821318_10 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000009325 197.0
HFD2_k127_5821318_11 - - - - 0.000000000000000000000000000000000000000000000002101 194.0
HFD2_k127_5821318_12 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000005147 171.0
HFD2_k127_5821318_13 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000222 123.0
HFD2_k127_5821318_14 DNA-templated transcription, initiation - - - 0.00000000000000000000000007608 117.0
HFD2_k127_5821318_15 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000002999 115.0
HFD2_k127_5821318_16 Methyltransferase domain - - - 0.000000000000000003958 96.0
HFD2_k127_5821318_17 Regulatory protein, FmdB - - - 0.00000000000000001301 85.0
HFD2_k127_5821318_18 Domain of unknown function (DUF4388) - - - 0.000000000005208 78.0
HFD2_k127_5821318_2 Type II secretion system (T2SS), protein F K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 449.0
HFD2_k127_5821318_20 Serine aminopeptidase, S33 - - - 0.0000001279 65.0
HFD2_k127_5821318_3 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005396 396.0
HFD2_k127_5821318_4 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008121 351.0
HFD2_k127_5821318_5 lipoprotein localization to outer membrane K02004,K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001075 277.0
HFD2_k127_5821318_6 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001893 271.0
HFD2_k127_5821318_7 molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003339 265.0
HFD2_k127_5821318_8 protein conserved in bacteria K09797 - - 0.00000000000000000000000000000000000000000000000000000000000000000002981 239.0
HFD2_k127_5821318_9 PFAM ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000106 238.0
HFD2_k127_5848787_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.749e-238 746.0
HFD2_k127_5848787_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 4.849e-217 684.0
HFD2_k127_5848787_10 UPF0391 membrane protein - - - 0.000003122 55.0
HFD2_k127_5848787_2 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007147 295.0
HFD2_k127_5848787_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000008438 223.0
HFD2_k127_5848787_4 cytochrome c nitrite reductase K15876 - - 0.00000000000000000000000000000000000000000000000000000000000347 212.0
HFD2_k127_5848787_5 peptidase - - - 0.0000000000000000000000000000000000000000000000000000006218 212.0
HFD2_k127_5848787_6 regulation of translation K03530 - - 0.00000000000000000000000000000002829 128.0
HFD2_k127_5848787_7 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.00000000000000000000000004041 115.0
HFD2_k127_5848787_8 Sortilin, neurotensin receptor 3, - - - 0.000000000000002222 90.0
HFD2_k127_5858175_0 Bacterial protein of unknown function (DUF885) - - - 1.726e-233 736.0
HFD2_k127_5858175_1 Involved in the tonB-independent uptake of proteins K01256,K03641 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 527.0
HFD2_k127_5858175_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 336.0
HFD2_k127_5858175_3 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001485 285.0
HFD2_k127_5858175_4 Thioesterase superfamily - - - 0.00000000000000000002326 104.0
HFD2_k127_5858175_5 Domain of unknown function (DUF4440) - - - 0.00000000000008652 78.0
HFD2_k127_5858175_6 PFAM Lipid A 3-O-deacylase-related - - - 0.00004549 54.0
HFD2_k127_5858175_7 oxidoreductase activity - - - 0.0006222 52.0
HFD2_k127_5866809_0 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 557.0
HFD2_k127_596800_0 Peptidase family S41 K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001019 285.0
HFD2_k127_596800_1 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000001237 205.0
HFD2_k127_596800_2 - - - - 0.0000000000000000000000000000007927 125.0
HFD2_k127_596800_3 SnoaL-like domain - - - 0.000000000000000000000003887 106.0
HFD2_k127_596800_4 - - - - 0.0000000000000000001861 102.0
HFD2_k127_596800_5 Acetyltransferase (GNAT) domain - - - 0.00000002676 57.0
HFD2_k127_596800_6 Ankyrin repeat - - - 0.0001452 54.0
HFD2_k127_5996495_0 Protein kinase domain K08884 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 437.0
HFD2_k127_5996495_1 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003776 365.0
HFD2_k127_5996495_2 Methyltransferase, chemotaxis proteins K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001751 296.0
HFD2_k127_5996495_3 Low affinity iron permease - - - 0.00000000000000000000000000000000000000000000006295 175.0
HFD2_k127_5996495_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000002742 175.0
HFD2_k127_5996495_5 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.00000000000000000001579 95.0
HFD2_k127_5996495_6 amine dehydrogenase activity - - - 0.0000003771 63.0
HFD2_k127_6055192_0 heavy metal translocating P-type ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000889 589.0
HFD2_k127_6055192_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000831 566.0
HFD2_k127_6055192_2 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006302 451.0
HFD2_k127_6055192_3 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 312.0
HFD2_k127_6055192_4 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000000000000000000000000000000000000000000000000223 191.0
HFD2_k127_6055192_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062,K18828 - - 0.0000000000000000000000000000000006089 135.0
HFD2_k127_6055192_6 outer membrane efflux protein - - - 0.000000000000000000000000000003721 136.0
HFD2_k127_6055192_7 Virulence associated protein B K18829 - - 0.00000000004691 66.0
HFD2_k127_6062241_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 2.147e-276 885.0
HFD2_k127_6062241_1 PAS fold - - - 3.301e-204 655.0
HFD2_k127_6062241_10 Tricorn protease homolog - - - 0.000000000000000000000000001203 115.0
HFD2_k127_6062241_11 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000002398 86.0
HFD2_k127_6062241_12 Putative adhesin - - - 0.000000004104 68.0
HFD2_k127_6062241_13 - - - - 0.00000002292 62.0
HFD2_k127_6062241_14 nuclease activity K06218 - - 0.0000001239 57.0
HFD2_k127_6062241_15 - - - - 0.000002769 57.0
HFD2_k127_6062241_16 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.00003864 50.0
HFD2_k127_6062241_17 Protein of unknown function (DUF3828) - - - 0.0001093 54.0
HFD2_k127_6062241_18 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0001723 54.0
HFD2_k127_6062241_2 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 523.0
HFD2_k127_6062241_3 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 331.0
HFD2_k127_6062241_4 tRNA 3'-trailer cleavage - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009082 323.0
HFD2_k127_6062241_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000165 243.0
HFD2_k127_6062241_6 gluconolactonase activity K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000003187 222.0
HFD2_k127_6062241_7 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000002165 214.0
HFD2_k127_6062241_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000002719 159.0
HFD2_k127_6062241_9 Transcriptional regulator K07506 - - 0.000000000000000000000000000000000002865 143.0
HFD2_k127_607534_0 Belongs to the UbiD family K03182 - 4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 595.0
HFD2_k127_607534_1 AAA ATPase, central domain protein K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005924 473.0
HFD2_k127_607534_2 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000008856 239.0
HFD2_k127_607534_3 response regulator - - - 0.000000000000000000000000000000000000000000000005325 188.0
HFD2_k127_607534_4 CarD-like/TRCF domain K07736 - - 0.000000000000000000000000000000000000008407 151.0
HFD2_k127_607534_5 SMART Tetratricopeptide - - - 0.0000000001942 73.0
HFD2_k127_607534_6 rhodanese-related sulfurtransferase - - - 0.0000007738 57.0
HFD2_k127_6099303_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 0.0 1273.0
HFD2_k127_6099303_1 imidazolonepropionase activity K01443 - 3.5.1.25 8.854e-211 687.0
HFD2_k127_6099303_2 imidazolonepropionase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 351.0
HFD2_k127_6099303_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 339.0
HFD2_k127_6099303_4 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002776 273.0
HFD2_k127_6099303_5 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000006301 163.0
HFD2_k127_6099303_6 EVE domain - - - 0.000000000000000000000000000000009915 146.0
HFD2_k127_6099303_7 Protein of unknown function (DUF2911) - - - 0.0000000000000000113 91.0
HFD2_k127_6099303_8 PFAM PKD domain containing protein - - - 0.000000003965 63.0
HFD2_k127_6099303_9 L,D-transpeptidase catalytic domain - - - 0.000001148 60.0
HFD2_k127_6136937_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 8.813e-233 749.0
HFD2_k127_6136937_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 337.0
HFD2_k127_6136937_10 Virulence activator alpha C-term - - - 0.00000000000000001026 90.0
HFD2_k127_6136937_11 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000001936 94.0
HFD2_k127_6136937_12 Putative zinc-finger - - - 0.0000004864 61.0
HFD2_k127_6136937_2 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001089 253.0
HFD2_k127_6136937_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001937 249.0
HFD2_k127_6136937_4 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000001486 222.0
HFD2_k127_6136937_5 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000001776 179.0
HFD2_k127_6136937_6 methylamine metabolic process - - - 0.0000000000000000000000000000000004133 145.0
HFD2_k127_6136937_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000005739 130.0
HFD2_k127_6136937_8 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01760 - 4.4.1.8 0.000000000000000000000000000005462 127.0
HFD2_k127_6136937_9 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000002734 94.0
HFD2_k127_6144599_0 NADPH:quinone reductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 401.0
HFD2_k127_6144599_1 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 359.0
HFD2_k127_6144599_2 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000004268 154.0
HFD2_k127_6144599_3 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000001148 116.0
HFD2_k127_6144599_4 - - - - 0.000000000000000000000001602 108.0
HFD2_k127_6144599_5 Tetratricopeptide repeat - - - 0.000000000000000000002426 94.0
HFD2_k127_6151281_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 3.702e-217 683.0
HFD2_k127_6151281_1 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 561.0
HFD2_k127_6151281_10 Doxx family K15977 - - 0.000000000000000000000000000000000000006385 156.0
HFD2_k127_6151281_11 protein conserved in bacteria - - - 0.000000000000000000000000000000000003666 143.0
HFD2_k127_6151281_2 sigma factor activity K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 467.0
HFD2_k127_6151281_3 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 386.0
HFD2_k127_6151281_4 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000001251 229.0
HFD2_k127_6151281_5 PFAM DGPFAETKE family protein - - - 0.000000000000000000000000000000000000000000000000000000000801 212.0
HFD2_k127_6151281_6 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000008777 179.0
HFD2_k127_6151281_7 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000003301 170.0
HFD2_k127_6151281_8 YCII-related domain - - - 0.000000000000000000000000000000000000000001159 159.0
HFD2_k127_6151281_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000002726 154.0
HFD2_k127_6168951_0 xanthine dehydrogenase activity - - - 0.0 1007.0
HFD2_k127_6168951_1 Insulinase (Peptidase family M16) K07263 - - 3.827e-203 642.0
HFD2_k127_6168951_10 Carbon-nitrogen hydrolase K01431,K12251 - 3.5.1.53,3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 469.0
HFD2_k127_6168951_11 Belongs to the allantoicase family K01477 - 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 427.0
HFD2_k127_6168951_12 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 391.0
HFD2_k127_6168951_13 Ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 367.0
HFD2_k127_6168951_14 CO dehydrogenase flavoprotein C-terminal domain K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 334.0
HFD2_k127_6168951_15 Multicopper oxidase K06324 - 1.16.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 338.0
HFD2_k127_6168951_16 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin K00365 - 1.7.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000005517 265.0
HFD2_k127_6168951_17 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001349 255.0
HFD2_k127_6168951_18 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000000000005568 193.0
HFD2_k127_6168951_2 PFAM amidohydrolase K01464 - 3.5.2.2 7.869e-200 634.0
HFD2_k127_6168951_21 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.51 0.000000000000000000000000000000000000002462 156.0
HFD2_k127_6168951_22 methyltransferase activity - - - 0.0000000000000000000000000000000000004817 145.0
HFD2_k127_6168951_23 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000007996 145.0
HFD2_k127_6168951_24 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.00000000000000000000000000000000009459 137.0
HFD2_k127_6168951_25 OHCU decarboxylase K16840 - 4.1.1.97 0.000000000000000000000000000000352 140.0
HFD2_k127_6168951_26 DNA methylase K07316 - 2.1.1.72 0.0000000000000000000002111 105.0
HFD2_k127_6168951_27 Periplasmic or secreted lipoprotein - - - 0.000000000000000556 81.0
HFD2_k127_6168951_28 Protein of unknown function (DUF1501) - - - 0.000000000000002836 87.0
HFD2_k127_6168951_29 PFAM Uncharacterised protein family (UPF0150) - - - 0.00000000002605 66.0
HFD2_k127_6168951_3 Sugar (and other) transporter K07058 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 1.413e-196 625.0
HFD2_k127_6168951_30 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000004292 68.0
HFD2_k127_6168951_31 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00005549 53.0
HFD2_k127_6168951_32 Excisionase - - - 0.0003338 52.0
HFD2_k127_6168951_4 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 596.0
HFD2_k127_6168951_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 586.0
HFD2_k127_6168951_6 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 559.0
HFD2_k127_6168951_7 Amidohydrolase family K01466 - 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 537.0
HFD2_k127_6168951_8 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 532.0
HFD2_k127_6168951_9 Peptidase, M16 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 494.0
HFD2_k127_6176229_0 PAS fold-4 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 529.0
HFD2_k127_6176229_1 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 513.0
HFD2_k127_6176229_3 Domain of unknown function (DUF4437) - - - 0.000005686 53.0
HFD2_k127_6187813_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.0 1034.0
HFD2_k127_6187813_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 6.496e-282 889.0
HFD2_k127_6187813_10 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 398.0
HFD2_k127_6187813_11 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 317.0
HFD2_k127_6187813_12 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 306.0
HFD2_k127_6187813_13 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 315.0
HFD2_k127_6187813_14 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 293.0
HFD2_k127_6187813_15 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002388 285.0
HFD2_k127_6187813_16 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003462 301.0
HFD2_k127_6187813_17 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003479 270.0
HFD2_k127_6187813_18 2Fe-2S -binding K13483 - - 0.000000000000000000000000000000000000000000000000000000000000000000002889 241.0
HFD2_k127_6187813_19 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000005007 244.0
HFD2_k127_6187813_2 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 4.936e-195 636.0
HFD2_k127_6187813_20 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000002854 237.0
HFD2_k127_6187813_21 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000002379 233.0
HFD2_k127_6187813_22 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000009758 234.0
HFD2_k127_6187813_23 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000001472 235.0
HFD2_k127_6187813_24 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000006809 210.0
HFD2_k127_6187813_25 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000003253 206.0
HFD2_k127_6187813_26 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000001313 195.0
HFD2_k127_6187813_27 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000012 202.0
HFD2_k127_6187813_28 - - - - 0.000000000000000000000000000000000000000000000119 185.0
HFD2_k127_6187813_29 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000008297 140.0
HFD2_k127_6187813_3 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006741 578.0
HFD2_k127_6187813_30 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000007365 147.0
HFD2_k127_6187813_31 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000002211 134.0
HFD2_k127_6187813_32 - - - - 0.000000000000000000000000000001327 130.0
HFD2_k127_6187813_33 Methyltransferase type 11 - - - 0.0000000000000000000000000001298 124.0
HFD2_k127_6187813_34 ferredoxin - - - 0.0000000000000000000000000004537 115.0
HFD2_k127_6187813_35 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000002785 131.0
HFD2_k127_6187813_36 cellulase activity K01218,K12132 - 2.7.11.1,3.2.1.78 0.000000000000000000000000009077 122.0
HFD2_k127_6187813_37 PFAM NHL repeat containing protein - - - 0.000000000000000000001343 111.0
HFD2_k127_6187813_38 NHL repeat - - - 0.000000000000000000003331 111.0
HFD2_k127_6187813_39 - - - - 0.0000000000003299 82.0
HFD2_k127_6187813_4 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000043 606.0
HFD2_k127_6187813_40 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000001044 73.0
HFD2_k127_6187813_41 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000264 81.0
HFD2_k127_6187813_42 Glucose Sorbosone dehydrogenase - - - 0.0000000008157 73.0
HFD2_k127_6187813_43 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000002232 72.0
HFD2_k127_6187813_44 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000006211 52.0
HFD2_k127_6187813_45 integral membrane protein - - - 0.000006552 54.0
HFD2_k127_6187813_46 Aldo/keto reductase family - - - 0.00002675 56.0
HFD2_k127_6187813_47 COG0346 Lactoylglutathione lyase and related lyases K07032 - - 0.0001023 50.0
HFD2_k127_6187813_5 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 500.0
HFD2_k127_6187813_6 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008842 516.0
HFD2_k127_6187813_7 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 486.0
HFD2_k127_6187813_8 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007401 425.0
HFD2_k127_6187813_9 Molybdopterin dehydrogenase K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 409.0
HFD2_k127_6242143_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 434.0
HFD2_k127_6242143_1 GGDEF domain K13590 - 2.7.7.65 0.000000000000000000000000004105 126.0
HFD2_k127_6242143_3 Thioredoxin - - - 0.00001926 51.0
HFD2_k127_6242143_4 - - - - 0.00005604 53.0
HFD2_k127_6271455_0 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 392.0
HFD2_k127_6271455_1 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000002248 164.0
HFD2_k127_6271455_2 Protein tyrosine kinase - - - 0.000000000000000000000001206 106.0
HFD2_k127_6287799_0 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000003547 125.0
HFD2_k127_6287799_1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa K09667 GO:0000003,GO:0000123,GO:0000785,GO:0000791,GO:0001678,GO:0001932,GO:0001933,GO:0001934,GO:0002119,GO:0002164,GO:0002237,GO:0003674,GO:0003824,GO:0004721,GO:0004722,GO:0005488,GO:0005515,GO:0005543,GO:0005547,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0005977,GO:0006040,GO:0006041,GO:0006047,GO:0006048,GO:0006073,GO:0006091,GO:0006109,GO:0006110,GO:0006111,GO:0006112,GO:0006139,GO:0006140,GO:0006325,GO:0006355,GO:0006357,GO:0006464,GO:0006470,GO:0006473,GO:0006475,GO:0006479,GO:0006486,GO:0006493,GO:0006508,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006996,GO:0007005,GO:0007154,GO:0007165,GO:0007275,GO:0007444,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0007626,GO:0008080,GO:0008134,GO:0008150,GO:0008152,GO:0008194,GO:0008213,GO:0008219,GO:0008289,GO:0008361,GO:0008375,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009725,GO:0009743,GO:0009746,GO:0009749,GO:0009791,GO:0009888,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009966,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010628,GO:0010638,GO:0010646,GO:0010675,GO:0010799,GO:0010801,GO:0010876,GO:0010906,GO:0010941,GO:0012501,GO:0012505,GO:0015980,GO:0016020,GO:0016043,GO:0016262,GO:0016311,GO:0016407,GO:0016410,GO:0016485,GO:0016569,GO:0016570,GO:0016571,GO:0016573,GO:0016579,GO:0016740,GO:0016746,GO:0016747,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0018022,GO:0018023,GO:0018130,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019725,GO:0019904,GO:0019915,GO:0022607,GO:0023051,GO:0023052,GO:0030141,GO:0030162,GO:0030246,GO:0030808,GO:0030811,GO:0031056,GO:0031058,GO:0031060,GO:0031062,GO:0031248,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031401,GO:0031410,GO:0031667,GO:0031974,GO:0031981,GO:0031982,GO:0032259,GO:0032268,GO:0032269,GO:0032270,GO:0032386,GO:0032387,GO:0032434,GO:0032435,GO:0032496,GO:0032501,GO:0032502,GO:0032535,GO:0032868,GO:0032879,GO:0032880,GO:0032922,GO:0032991,GO:0033036,GO:0033043,GO:0033044,GO:0033135,GO:0033137,GO:0033157,GO:0033218,GO:0033500,GO:0033993,GO:0034284,GO:0034641,GO:0034645,GO:0034654,GO:0034968,GO:0035020,GO:0035091,GO:0035220,GO:0035295,GO:0035556,GO:0036094,GO:0036211,GO:0036477,GO:0040024,GO:0042176,GO:0042177,GO:0042221,GO:0042277,GO:0042325,GO:0042326,GO:0042327,GO:0042578,GO:0042588,GO:0042592,GO:0042593,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043255,GO:0043412,GO:0043413,GO:0043414,GO:0043434,GO:0043467,GO:0043470,GO:0043543,GO:0043933,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0045475,GO:0045793,GO:0045861,GO:0045862,GO:0045893,GO:0045935,GO:0045936,GO:0045937,GO:0045944,GO:0046349,GO:0046483,GO:0046578,GO:0046626,GO:0048015,GO:0048017,GO:0048029,GO:0048311,GO:0048312,GO:0048471,GO:0048511,GO:0048512,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051056,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051193,GO:0051196,GO:0051223,GO:0051224,GO:0051235,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051276,GO:0051291,GO:0051568,GO:0051604,GO:0051640,GO:0051641,GO:0051646,GO:0051704,GO:0051707,GO:0051716,GO:0055082,GO:0055086,GO:0055114,GO:0060255,GO:0060341,GO:0060429,GO:0060548,GO:0061085,GO:0061087,GO:0061136,GO:0062012,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070085,GO:0070201,GO:0070206,GO:0070207,GO:0070208,GO:0070646,GO:0070647,GO:0070887,GO:0071216,GO:0071219,GO:0071222,GO:0071310,GO:0071322,GO:0071326,GO:0071331,GO:0071333,GO:0071396,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0080182,GO:0090066,GO:0090087,GO:0090313,GO:0090315,GO:0090317,GO:0097363,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:0140096,GO:1900037,GO:1900038,GO:1900076,GO:1900180,GO:1900182,GO:1900371,GO:1900542,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901652,GO:1901698,GO:1901700,GO:1901701,GO:1901799,GO:1901981,GO:1902275,GO:1902493,GO:1902494,GO:1902531,GO:1902680,GO:1903050,GO:1903051,GO:1903320,GO:1903321,GO:1903362,GO:1903363,GO:1903426,GO:1903428,GO:1903506,GO:1903508,GO:1903533,GO:1903578,GO:1903827,GO:1903828,GO:1903829,GO:1904950,GO:1905269,GO:1905475,GO:1905476,GO:1990234,GO:2000058,GO:2000059,GO:2000112,GO:2000377,GO:2000379,GO:2001141,GO:2001169,GO:2001252 2.4.1.255 0.0000000000000000000002382 110.0
HFD2_k127_6287799_2 response to nickel cation - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0040008,GO:0045926,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0065007,GO:0097159,GO:1901363 - 0.0000000000000000387 84.0
HFD2_k127_6287799_3 nuclease activity K06218 - - 0.00000000000006255 74.0
HFD2_k127_6334906_0 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.163e-234 749.0
HFD2_k127_6334906_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.139e-211 691.0
HFD2_k127_6334906_10 CoA binding domain K06929 - - 0.00000000000000000000000000000000004595 139.0
HFD2_k127_6334906_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000001326 125.0
HFD2_k127_6334906_12 Zincin-like metallopeptidase - - - 0.00000000000000000000002669 110.0
HFD2_k127_6334906_13 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000008984 96.0
HFD2_k127_6334906_14 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000002907 95.0
HFD2_k127_6334906_15 - - - - 0.000000000000000001107 97.0
HFD2_k127_6334906_16 Protein of unknown function (DUF503) K09764 - - 0.000000000000000009116 85.0
HFD2_k127_6334906_17 TonB C terminal - - - 0.000000001226 70.0
HFD2_k127_6334906_18 Psort location CytoplasmicMembrane, score - - - 0.00000005589 60.0
HFD2_k127_6334906_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 479.0
HFD2_k127_6334906_3 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 361.0
HFD2_k127_6334906_4 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 344.0
HFD2_k127_6334906_5 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 304.0
HFD2_k127_6334906_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000244 205.0
HFD2_k127_6334906_7 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000002433 210.0
HFD2_k127_6334906_8 Hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000000000000000000000003283 199.0
HFD2_k127_6334906_9 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000001297 191.0
HFD2_k127_6375534_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 3.933e-296 916.0
HFD2_k127_6375534_1 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 2.431e-197 676.0
HFD2_k127_6375534_10 - - - - 0.0000000000000000000008328 100.0
HFD2_k127_6375534_11 Peptidase MA superfamily - - - 0.0003497 47.0
HFD2_k127_6375534_2 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 484.0
HFD2_k127_6375534_3 Domain of unknown function (DUF5009) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 329.0
HFD2_k127_6375534_4 saccharopine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 333.0
HFD2_k127_6375534_5 eRF1 domain 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001501 296.0
HFD2_k127_6375534_6 enzyme related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006742 266.0
HFD2_k127_6375534_7 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000001238 259.0
HFD2_k127_6375534_8 Metallopeptidase family M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000004387 239.0
HFD2_k127_6375534_9 Protein of unknown function (DUF3313) - - - 0.00000000000000000000000000000000000000974 156.0
HFD2_k127_6376817_0 ACT domain K12524 - 1.1.1.3,2.7.2.4 7.538e-268 850.0
HFD2_k127_6376817_1 4Fe-4S binding domain - - - 2.143e-243 781.0
HFD2_k127_6376817_10 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 404.0
HFD2_k127_6376817_11 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009625 383.0
HFD2_k127_6376817_12 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 359.0
HFD2_k127_6376817_13 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 369.0
HFD2_k127_6376817_14 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 345.0
HFD2_k127_6376817_15 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009762 330.0
HFD2_k127_6376817_16 glycosyl hydrolase, BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 299.0
HFD2_k127_6376817_17 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002189 289.0
HFD2_k127_6376817_18 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008493 273.0
HFD2_k127_6376817_19 Hep Hag repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004843 283.0
HFD2_k127_6376817_2 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 6.533e-220 695.0
HFD2_k127_6376817_20 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003236 266.0
HFD2_k127_6376817_21 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000004119 259.0
HFD2_k127_6376817_22 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000000000006766 235.0
HFD2_k127_6376817_23 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000008411 213.0
HFD2_k127_6376817_24 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000001961 207.0
HFD2_k127_6376817_25 GHMP kinases C terminal K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0050896,GO:0051704,GO:0051707,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000000000000000000000000000007644 215.0
HFD2_k127_6376817_26 Biotin/lipoate A/B protein ligase family K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000001767 210.0
HFD2_k127_6376817_27 Methyltransferase domain - - - 0.00000000000000000000000000000000000000005337 159.0
HFD2_k127_6376817_28 MoaC family K03637 - 4.6.1.17 0.0000000000000000000000000000000000000001247 162.0
HFD2_k127_6376817_29 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000001678 158.0
HFD2_k127_6376817_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 520.0
HFD2_k127_6376817_30 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000008345 149.0
HFD2_k127_6376817_31 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000001759 144.0
HFD2_k127_6376817_32 Radical SAM K22227 - - 0.0000000000000000000000000000000002814 149.0
HFD2_k127_6376817_34 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000003032 113.0
HFD2_k127_6376817_35 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000007055 88.0
HFD2_k127_6376817_36 amine dehydrogenase activity - - - 0.00000000000003633 87.0
HFD2_k127_6376817_37 Glycosyl transferase family group 2 - - - 0.0000000000001796 81.0
HFD2_k127_6376817_38 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.000000000004743 74.0
HFD2_k127_6376817_4 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 512.0
HFD2_k127_6376817_40 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000001506 73.0
HFD2_k127_6376817_41 TIGRFAM TonB family protein K03832 - - 0.000000003248 69.0
HFD2_k127_6376817_5 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 522.0
HFD2_k127_6376817_6 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 501.0
HFD2_k127_6376817_8 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 414.0
HFD2_k127_6376817_9 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 394.0
HFD2_k127_6459906_0 Carboxypeptidase regulatory-like domain - - - 2.053e-213 695.0
HFD2_k127_6459906_1 A G-specific K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000002229 261.0
HFD2_k127_6459906_10 Polysaccharide biosynthesis protein - - - 0.000000000001193 77.0
HFD2_k127_6459906_11 Uncharacterised protein family (UPF0158) - - - 0.0001126 50.0
HFD2_k127_6459906_12 Bacterial membrane protein YfhO - - - 0.0001413 51.0
HFD2_k127_6459906_2 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000001747 225.0
HFD2_k127_6459906_3 - - - - 0.000000000000000000000000000000000000000002305 163.0
HFD2_k127_6459906_4 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000006367 164.0
HFD2_k127_6459906_5 DREV methyltransferase - - - 0.00000000000000000000000000000000375 146.0
HFD2_k127_6459906_6 Methyltransferase domain - - - 0.00000000000000000000000000000001356 138.0
HFD2_k127_6459906_7 Protein of unknown function DUF86 - - - 0.000000000000000000001509 105.0
HFD2_k127_6459906_8 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000007134 99.0
HFD2_k127_6459906_9 nucleotidyltransferase activity - - - 0.0000000000001846 78.0
HFD2_k127_6526722_0 PFAM Mo-co oxidoreductase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 535.0
HFD2_k127_6526722_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 452.0
HFD2_k127_6526722_10 - - - - 0.00000000000000000000000000000000000000000000000005584 185.0
HFD2_k127_6526722_11 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000000001458 170.0
HFD2_k127_6526722_12 LexA-binding, inner membrane-associated putative hydrolase K07038 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000006594 162.0
HFD2_k127_6526722_13 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000007929 163.0
HFD2_k127_6526722_14 - - - - 0.0000000000000000000000000000000000000116 157.0
HFD2_k127_6526722_15 - - - - 0.00000000000000000000000000000004075 131.0
HFD2_k127_6526722_16 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000003468 128.0
HFD2_k127_6526722_17 Glyoxalase-like domain - - - 0.000000000000000000000000000004493 130.0
HFD2_k127_6526722_18 SnoaL-like domain - - - 0.000000000000000000000000006725 119.0
HFD2_k127_6526722_19 YCII-related domain - - - 0.0000000000000000000006185 109.0
HFD2_k127_6526722_2 tetratricopeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 446.0
HFD2_k127_6526722_20 - - - - 0.0000000000000000007119 88.0
HFD2_k127_6526722_21 4Fe-4S single cluster domain of Ferredoxin I - - - 0.0000000000000005096 81.0
HFD2_k127_6526722_22 Phosphoribosyl transferase domain K00762 - 2.4.2.10 0.00000000000001666 78.0
HFD2_k127_6526722_25 PFAM SEC-C motif domain protein - - - 0.00003229 52.0
HFD2_k127_6526722_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 419.0
HFD2_k127_6526722_4 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 398.0
HFD2_k127_6526722_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 302.0
HFD2_k127_6526722_6 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000257 284.0
HFD2_k127_6526722_7 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000023 264.0
HFD2_k127_6526722_8 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000002794 237.0
HFD2_k127_6526722_9 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000276 198.0
HFD2_k127_6541939_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006,K22424 - 2.7.3.13,2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 476.0
HFD2_k127_6541939_1 Glycyl-tRNA synthetase beta subunit K01879,K14164 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 455.0
HFD2_k127_6541939_2 PFAM glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 369.0
HFD2_k127_6541939_3 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000001 202.0
HFD2_k127_6541939_4 COGs COG3603 conserved K09707 - - 0.0000000000000000000001913 110.0
HFD2_k127_6541939_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000001067 102.0
HFD2_k127_6622432_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.377e-248 792.0
HFD2_k127_6622432_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 1.53e-221 700.0
HFD2_k127_6622432_10 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 385.0
HFD2_k127_6622432_11 Phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 362.0
HFD2_k127_6622432_12 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 351.0
HFD2_k127_6622432_13 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 317.0
HFD2_k127_6622432_14 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 309.0
HFD2_k127_6622432_15 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003712 289.0
HFD2_k127_6622432_16 -acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001234 287.0
HFD2_k127_6622432_17 PFAM Ribonuclease BN-like family K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002335 261.0
HFD2_k127_6622432_18 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000006547 252.0
HFD2_k127_6622432_19 DNA polymerase III subunit epsilon K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000001504 242.0
HFD2_k127_6622432_2 Phospholipase D Transphosphatidylase K06131 - - 2.924e-204 648.0
HFD2_k127_6622432_20 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000004683 243.0
HFD2_k127_6622432_21 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000009712 234.0
HFD2_k127_6622432_22 5'-nucleotidase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002025 247.0
HFD2_k127_6622432_23 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000001117 224.0
HFD2_k127_6622432_24 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000007975 220.0
HFD2_k127_6622432_25 Acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000001901 213.0
HFD2_k127_6622432_26 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000002165 211.0
HFD2_k127_6622432_27 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000000000000000000000000000000000002285 193.0
HFD2_k127_6622432_28 - - - - 0.000000000000000000000000000000000000000000000007649 196.0
HFD2_k127_6622432_29 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000585 174.0
HFD2_k127_6622432_3 xanthine dehydrogenase activity K07303 - 1.3.99.16 4.1e-200 654.0
HFD2_k127_6622432_30 Low affinity iron permease - - - 0.00000000000000000000000000000000002717 154.0
HFD2_k127_6622432_31 Peptidase family M54 K06974 - - 0.00000000000000000000000000000005172 135.0
HFD2_k127_6622432_32 Fic/DOC family K07341 - - 0.00000000000000000000000000006312 119.0
HFD2_k127_6622432_33 periplasmic or secreted lipoprotein - - - 0.00000000000000000000000732 117.0
HFD2_k127_6622432_34 SMART RNP-1 like RNA-binding protein - - - 0.00000000000000000000001068 114.0
HFD2_k127_6622432_35 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000003675 85.0
HFD2_k127_6622432_36 Thioesterase-like superfamily K07107 - - 0.000000000000002921 81.0
HFD2_k127_6622432_37 hydrolase of the alpha beta superfamily K07017 - - 0.000000000000005789 82.0
HFD2_k127_6622432_38 - - - - 0.00000000000001691 85.0
HFD2_k127_6622432_39 CopG domain protein DNA-binding domain protein K18918 - - 0.0000000000005755 71.0
HFD2_k127_6622432_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 490.0
HFD2_k127_6622432_40 nuclease activity K06218 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000001033 71.0
HFD2_k127_6622432_41 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000002252 80.0
HFD2_k127_6622432_42 Beta-lactamase superfamily domain - - - 0.000000001659 64.0
HFD2_k127_6622432_43 WYL domain - - - 0.00000004477 57.0
HFD2_k127_6622432_44 Acyl-CoA synthetase family member 4 K00142 GO:0001505,GO:0003674,GO:0003824,GO:0006082,GO:0006518,GO:0006520,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016877,GO:0016878,GO:0019184,GO:0019482,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0043038,GO:0043041,GO:0043043,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.0000001146 59.0
HFD2_k127_6622432_5 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 481.0
HFD2_k127_6622432_6 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 415.0
HFD2_k127_6622432_7 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 404.0
HFD2_k127_6622432_8 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 387.0
HFD2_k127_6622432_9 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 390.0
HFD2_k127_6647192_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008116 612.0
HFD2_k127_6647192_1 proline dipeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 551.0
HFD2_k127_6647192_10 carboxypeptidase activity K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000001709 209.0
HFD2_k127_6647192_11 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000008375 200.0
HFD2_k127_6647192_12 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000009429 186.0
HFD2_k127_6647192_13 Peptidase family M50 K06402 - - 0.0000000000000000000000000000000000000000000667 168.0
HFD2_k127_6647192_14 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000448 164.0
HFD2_k127_6647192_15 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000005001 148.0
HFD2_k127_6647192_16 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.000000000000000000000000000000009426 129.0
HFD2_k127_6647192_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000009302 118.0
HFD2_k127_6647192_18 cyclic nucleotide-binding K10914 - - 0.0000000000000000000007123 105.0
HFD2_k127_6647192_19 Domain of unknown function (DUF4388) - - - 0.0000000000000000008974 100.0
HFD2_k127_6647192_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 502.0
HFD2_k127_6647192_20 Domain of unknown function (DUF1732) - - - 0.0000000000000006091 84.0
HFD2_k127_6647192_22 Domain of unknown function (DUF4126) - - - 0.0000000001487 70.0
HFD2_k127_6647192_23 DnaJ molecular chaperone homology domain - - - 0.00000008179 65.0
HFD2_k127_6647192_24 Domain of unknown function (DUF4388) - - - 0.0000001277 64.0
HFD2_k127_6647192_25 TM2 domain - - - 0.0000007013 59.0
HFD2_k127_6647192_26 carboxylic ester hydrolase activity - - - 0.00008203 51.0
HFD2_k127_6647192_27 HEAT repeats - - - 0.0001279 54.0
HFD2_k127_6647192_29 - - - - 0.0009594 44.0
HFD2_k127_6647192_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 484.0
HFD2_k127_6647192_4 Oxidoreductase family, C-terminal alpha beta domain K00118,K13020 - 1.1.1.335,1.1.99.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 423.0
HFD2_k127_6647192_5 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000557 438.0
HFD2_k127_6647192_6 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 385.0
HFD2_k127_6647192_7 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 297.0
HFD2_k127_6647192_8 NAD(P)H-binding K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000002624 229.0
HFD2_k127_6647192_9 Belongs to the pseudouridine synthase RsuA family K06178,K06182,K06183 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000001176 221.0
HFD2_k127_6748527_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 7.03e-214 691.0
HFD2_k127_6748527_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.991e-205 654.0
HFD2_k127_6748527_10 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 301.0
HFD2_k127_6748527_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000001095 253.0
HFD2_k127_6748527_12 PFAM Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000002446 248.0
HFD2_k127_6748527_13 Outer membrane receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000001591 259.0
HFD2_k127_6748527_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000003069 233.0
HFD2_k127_6748527_15 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001458 225.0
HFD2_k127_6748527_16 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000001542 222.0
HFD2_k127_6748527_17 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000007454 225.0
HFD2_k127_6748527_18 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.000000000000000000000000000000000000000000000000001301 195.0
HFD2_k127_6748527_19 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000032 201.0
HFD2_k127_6748527_2 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 533.0
HFD2_k127_6748527_20 May be involved in the transport of PQQ or its precursor to the periplasm - - - 0.000000000000000000000000000000000000000000000378 175.0
HFD2_k127_6748527_21 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000001706 175.0
HFD2_k127_6748527_22 Protein of unknown function, DUF547 - - - 0.0000000000000000000000000000000000000009262 160.0
HFD2_k127_6748527_23 Cytochrome oxidase assembly protein K02259 - - 0.000000000000000000000000000000000000008143 156.0
HFD2_k127_6748527_24 PFAM ABC transporter related K02193 - 3.6.3.41 0.0000000000000000000000000000000000001588 149.0
HFD2_k127_6748527_25 CcmB protein K02194 - - 0.0000000000000000000000000000000000007423 150.0
HFD2_k127_6748527_26 - - - - 0.0000000000000000000000000007236 118.0
HFD2_k127_6748527_27 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000004397 108.0
HFD2_k127_6748527_28 oxidoreductase activity - - - 0.0000000000000002926 92.0
HFD2_k127_6748527_29 oxidoreductase activity - - - 0.000000000001038 81.0
HFD2_k127_6748527_3 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 491.0
HFD2_k127_6748527_30 HDOD domain - - - 0.00000004699 66.0
HFD2_k127_6748527_31 Peptidase M56 - - - 0.000005605 59.0
HFD2_k127_6748527_32 sequence-specific DNA binding K15773 - - 0.000007211 52.0
HFD2_k127_6748527_33 S-layer homology domain - - - 0.0003183 51.0
HFD2_k127_6748527_4 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000608 440.0
HFD2_k127_6748527_5 PFAM acyl-CoA dehydrogenase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 422.0
HFD2_k127_6748527_6 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 405.0
HFD2_k127_6748527_7 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 401.0
HFD2_k127_6748527_8 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 323.0
HFD2_k127_6748527_9 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 307.0
HFD2_k127_6860886_0 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 484.0
HFD2_k127_6860886_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005536 311.0
HFD2_k127_6860886_2 proline dehydrogenase activity K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001288 287.0
HFD2_k127_6860886_4 Competence protein - - - 0.00000000000000000004457 100.0
HFD2_k127_6860886_5 Major facilitator Superfamily - - - 0.0003404 53.0
HFD2_k127_6978779_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1625.0
HFD2_k127_6978779_1 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 9.571e-271 835.0
HFD2_k127_6978779_10 Helix-hairpin-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001018 254.0
HFD2_k127_6978779_11 PFAM iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000000003195 202.0
HFD2_k127_6978779_12 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000009626 197.0
HFD2_k127_6978779_13 - - - - 0.0000000000000000000000000000000002465 150.0
HFD2_k127_6978779_14 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.00000000000000000000000000000003027 133.0
HFD2_k127_6978779_15 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000009404 106.0
HFD2_k127_6978779_16 protein conserved in bacteria - - - 0.0000000000000000006484 95.0
HFD2_k127_6978779_17 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000001896 92.0
HFD2_k127_6978779_19 MacB-like periplasmic core domain K02004 - - 0.00002085 49.0
HFD2_k127_6978779_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 2.181e-204 662.0
HFD2_k127_6978779_3 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 595.0
HFD2_k127_6978779_4 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 602.0
HFD2_k127_6978779_5 Periplasmic copper-binding protein (NosD) K07218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 587.0
HFD2_k127_6978779_6 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 570.0
HFD2_k127_6978779_7 ABC transporter K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 366.0
HFD2_k127_6978779_8 lipoprotein involved in nitrous oxide reduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001734 272.0
HFD2_k127_6978779_9 ABC-2 family transporter protein K19341 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002886 283.0
HFD2_k127_6978919_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 4.317e-267 845.0
HFD2_k127_6978919_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 548.0
HFD2_k127_6978919_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008719 551.0
HFD2_k127_6978919_3 AAA-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 529.0
HFD2_k127_6978919_4 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 439.0
HFD2_k127_6978919_5 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 405.0
HFD2_k127_6978919_6 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 284.0
HFD2_k127_6978919_7 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000001482 212.0
HFD2_k127_6978919_8 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000002367 191.0
HFD2_k127_6978919_9 PilZ domain - - - 0.0009325 46.0
HFD2_k127_7023707_0 Sodium:dicarboxylate symporter family K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 434.0
HFD2_k127_7023707_1 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000618 332.0
HFD2_k127_7023707_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000116 129.0
HFD2_k127_7023707_3 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000000002055 119.0
HFD2_k127_7023707_4 AraC-like ligand binding domain - - - 0.000042 52.0
HFD2_k127_7031553_0 Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 618.0
HFD2_k127_7031553_1 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 584.0
HFD2_k127_7031553_10 metallopeptidase activity K20276 - - 0.00000000000000000000000000000000000000000000000004085 202.0
HFD2_k127_7031553_11 cell septum assembly - - - 0.0000000000000000000000000000000000000004152 166.0
HFD2_k127_7031553_12 Kelch motif - - - 0.0000000000000000000000000000000000001059 156.0
HFD2_k127_7031553_13 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000007574 140.0
HFD2_k127_7031553_14 proteolysis - - - 0.0000000000000000000000000002658 127.0
HFD2_k127_7031553_15 Methionine biosynthesis protein MetW - - - 0.000000000000007906 83.0
HFD2_k127_7031553_16 - - - - 0.0000003128 61.0
HFD2_k127_7031553_17 PA14 domain - GO:0005575,GO:0005576 - 0.00001515 58.0
HFD2_k127_7031553_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 461.0
HFD2_k127_7031553_3 Aminotransferase K14267,K14287 - 2.6.1.17,2.6.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 467.0
HFD2_k127_7031553_4 Cys/Met metabolism PLP-dependent enzyme K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 436.0
HFD2_k127_7031553_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 381.0
HFD2_k127_7031553_6 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 378.0
HFD2_k127_7031553_7 Amino acid permease K20265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 329.0
HFD2_k127_7031553_8 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008698 269.0
HFD2_k127_7031553_9 COG1943 Transposase and inactivated derivatives K07491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006896 254.0
HFD2_k127_7034845_0 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 593.0
HFD2_k127_7034845_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 545.0
HFD2_k127_7034845_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000001058 156.0
HFD2_k127_7034845_11 Glycosyl transferase - - - 0.000000000000000000000000000000006001 140.0
HFD2_k127_7034845_12 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000002842 138.0
HFD2_k127_7034845_13 Hfq protein - - - 0.0000000000000000000000000000005294 125.0
HFD2_k127_7034845_14 Glycosyltransferase family 92 - - - 0.000000000000000000000008874 116.0
HFD2_k127_7034845_15 peptidase inhibitor activity - - - 0.00000000000000007813 96.0
HFD2_k127_7034845_16 TIGRFAM addiction module toxin, RelE StbE family K06218 - - 0.000000000000001815 80.0
HFD2_k127_7034845_17 Antitoxin component of a toxin-antitoxin (TA) module - GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141 - 0.0000000002723 73.0
HFD2_k127_7034845_18 Bacteriophage replication gene A protein (GPA) - - - 0.0000000008652 61.0
HFD2_k127_7034845_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 451.0
HFD2_k127_7034845_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009383 404.0
HFD2_k127_7034845_4 Bacterial sugar transferase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 396.0
HFD2_k127_7034845_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 348.0
HFD2_k127_7034845_6 Domain of unknown function (DUF1972) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 351.0
HFD2_k127_7034845_7 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000823 244.0
HFD2_k127_7034845_8 PSP1 C-terminal conserved region - - - 0.000000000000000000000000000000000000000000000000000000463 203.0
HFD2_k127_7034845_9 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.0000000000000000000000000000000000000000002736 159.0
HFD2_k127_7043844_0 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 354.0
HFD2_k127_7043844_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 350.0
HFD2_k127_7043844_2 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000001894 225.0
HFD2_k127_7043844_3 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000002315 176.0
HFD2_k127_7043844_4 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000003751 168.0
HFD2_k127_7043844_5 chaperone-mediated protein folding - - - 0.000000000004698 79.0
HFD2_k127_7043844_6 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0009806 51.0
HFD2_k127_7051805_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 394.0
HFD2_k127_7051805_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007809 313.0
HFD2_k127_7051805_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000006106 154.0
HFD2_k127_7051805_3 glucan 1,4-alpha-glucosidase activity K05989,K20541 - 3.2.1.40 0.00000000000001503 85.0
HFD2_k127_7063837_0 Peptidase m28 - - - 2.624e-225 719.0
HFD2_k127_7063837_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004411 522.0
HFD2_k127_7063837_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 483.0
HFD2_k127_7063837_3 COG3540 Phosphodiesterase alkaline phosphatase D K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 443.0
HFD2_k127_7063837_4 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 433.0
HFD2_k127_7063837_5 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 359.0
HFD2_k127_7063837_6 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000007761 123.0
HFD2_k127_7153244_0 Hydrolase CocE NonD family - - - 5.166e-303 943.0
HFD2_k127_7153244_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 535.0
HFD2_k127_7153244_2 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002929 301.0
HFD2_k127_7153244_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000007644 248.0
HFD2_k127_7153244_4 cytochrome - - - 0.0000000000000000000000000000000000000000000000000004315 189.0
HFD2_k127_7153244_5 Acetamidase/Formamidase family - - - 0.000000000000000000000000000000000000000000000982 173.0
HFD2_k127_7153244_6 SnoaL-like polyketide cyclase - - - 0.0000000000000000006668 95.0
HFD2_k127_7169634_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 7.181e-242 758.0
HFD2_k127_7169634_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 464.0
HFD2_k127_7169634_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000000000000000000000000000007633 147.0
HFD2_k127_7169634_3 - - - - 0.000005101 59.0
HFD2_k127_7198698_0 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 338.0
HFD2_k127_7198698_1 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008945 345.0
HFD2_k127_7198698_2 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000000002127 209.0
HFD2_k127_7198698_3 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000079 133.0
HFD2_k127_7203551_0 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 385.0
HFD2_k127_7203551_1 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 335.0
HFD2_k127_7203551_2 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 300.0
HFD2_k127_7203551_3 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000298 233.0
HFD2_k127_7203551_4 permease K03548 - - 0.0000000000000000000000000000000000000000000000002248 191.0
HFD2_k127_7203551_5 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000002496 154.0
HFD2_k127_7203551_6 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000003004 122.0
HFD2_k127_7203551_7 Glycosyltransferase family 87 - - - 0.00003766 56.0
HFD2_k127_7241475_0 oligopeptide transporter, OPT family - - - 3.356e-221 706.0
HFD2_k127_7241475_1 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007161 557.0
HFD2_k127_7241475_10 Glucose dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001521 277.0
HFD2_k127_7241475_11 PFAM Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000002774 217.0
HFD2_k127_7241475_12 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000005971 189.0
HFD2_k127_7241475_13 Putative glycolipid-binding K09957 - - 0.0000000000000000000000000000000000000000000001675 179.0
HFD2_k127_7241475_15 mannitol 2-dehydrogenase activity K11690 - - 0.0000000000000000000000000000000000001706 143.0
HFD2_k127_7241475_16 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000007464 162.0
HFD2_k127_7241475_17 von Willebrand factor, type A - - - 0.0000000000000000000000000007208 131.0
HFD2_k127_7241475_18 synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000003043 115.0
HFD2_k127_7241475_19 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000000000007268 72.0
HFD2_k127_7241475_2 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 454.0
HFD2_k127_7241475_20 F420H(2)-dependent quinone reductase - - - 0.000000000006767 75.0
HFD2_k127_7241475_21 - - - - 0.00000000004187 68.0
HFD2_k127_7241475_22 - - - - 0.0000005313 61.0
HFD2_k127_7241475_23 Putative porin - - - 0.000006271 58.0
HFD2_k127_7241475_24 Outer membrane protein beta-barrel domain K07275 - - 0.00003463 54.0
HFD2_k127_7241475_3 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 424.0
HFD2_k127_7241475_4 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 399.0
HFD2_k127_7241475_5 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 408.0
HFD2_k127_7241475_6 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 351.0
HFD2_k127_7241475_7 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007383 315.0
HFD2_k127_7241475_8 Asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 322.0
HFD2_k127_7241475_9 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008848 277.0
HFD2_k127_7251915_0 ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 449.0
HFD2_k127_7251915_1 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 421.0
HFD2_k127_7251915_10 PFAM glycosyl transferase family 2 K14597 - - 0.00000000000000000000000000000000000000000000000001016 195.0
HFD2_k127_7251915_11 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000002994 161.0
HFD2_k127_7251915_12 iron-sulfur cluster assembly K07400 - - 0.0000000000000000000000000000000000000001794 158.0
HFD2_k127_7251915_13 nuclease activity K18828 - - 0.0000000000000000000000000000000000006445 148.0
HFD2_k127_7251915_14 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.000000000000000000000000000000000002168 152.0
HFD2_k127_7251915_15 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000003816 152.0
HFD2_k127_7251915_16 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000003016 110.0
HFD2_k127_7251915_17 Tetratricopeptide repeat-like domain - - - 0.00006152 53.0
HFD2_k127_7251915_2 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 398.0
HFD2_k127_7251915_3 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 388.0
HFD2_k127_7251915_4 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 390.0
HFD2_k127_7251915_5 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 317.0
HFD2_k127_7251915_6 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 299.0
HFD2_k127_7251915_7 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001863 289.0
HFD2_k127_7251915_8 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003419 279.0
HFD2_k127_7251915_9 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003069 288.0
HFD2_k127_7254966_0 Glycosyl transferases group 1 - - - 2.775e-204 653.0
HFD2_k127_7254966_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 297.0
HFD2_k127_7254966_2 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000002321 208.0
HFD2_k127_7254966_3 methyltransferase - - - 0.000000000000000000000000000000000000000001759 162.0
HFD2_k127_7254966_4 Polysaccharide deacetylase - - - 0.000000000000000000000000000000034 145.0
HFD2_k127_7254966_5 ATP hydrolysis coupled proton transport - - - 0.00002606 52.0
HFD2_k127_7433011_0 Involved in the tonB-independent uptake of proteins - - - 5.643e-213 689.0
HFD2_k127_7433011_1 involved in signal transduction (via phosphorylation) involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites catalytic activity ATP a protein ADP a phosphoprotein K08282 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 350.0
HFD2_k127_7433011_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000003992 79.0
HFD2_k127_7510169_0 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 596.0
HFD2_k127_7510169_1 protein-disulfide reductase activity K04084,K06196 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 408.0
HFD2_k127_7510169_2 Represses a number of genes involved in the response to DNA damage (SOS response) K01356,K03503 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000001606 212.0
HFD2_k127_7510169_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000004087 211.0
HFD2_k127_7510169_4 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000006095 144.0
HFD2_k127_7510169_5 Highly conserved protein containing a thioredoxin domain - - - 0.0000007223 61.0
HFD2_k127_7540939_0 Extracellular solute-binding protein K02027 - - 1.806e-229 717.0
HFD2_k127_7540939_1 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 454.0
HFD2_k127_7540939_10 - - - - 0.00000000000000001431 85.0
HFD2_k127_7540939_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K21137 - - 0.0000000000000001138 90.0
HFD2_k127_7540939_12 S4 RNA-binding domain K04762 - - 0.00000000000001365 82.0
HFD2_k127_7540939_13 PFAM conserved K06966 - 3.2.2.10 0.00000000000002143 80.0
HFD2_k127_7540939_14 DNA-sulfur modification-associated - - - 0.000005521 58.0
HFD2_k127_7540939_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 434.0
HFD2_k127_7540939_3 Binding-protein-dependent transport system inner membrane component K02025,K10118,K10237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 433.0
HFD2_k127_7540939_4 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 378.0
HFD2_k127_7540939_5 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000001137 224.0
HFD2_k127_7540939_6 Belongs to the Dps family K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000001233 216.0
HFD2_k127_7540939_7 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000007789 203.0
HFD2_k127_7540939_8 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000002213 124.0
HFD2_k127_7540939_9 GGDEF domain containing protein - - - 0.000000000000000000003801 106.0
HFD2_k127_7651543_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.619e-315 984.0
HFD2_k127_7651543_1 Domain of unknown function (DUF4215) - - - 0.00000000001201 76.0
HFD2_k127_7652822_0 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000008922 221.0
HFD2_k127_7652822_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000001099 211.0
HFD2_k127_7652822_2 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000001418 189.0
HFD2_k127_7652822_3 ATP hydrolysis coupled proton transport K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000003856 59.0
HFD2_k127_7652822_4 Putative zinc-finger - - - 0.00004254 55.0
HFD2_k127_7655104_0 AAA ATPase domain - - - 7.284e-304 965.0
HFD2_k127_7655104_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 571.0
HFD2_k127_7655104_10 molybdopterin K03750 - 2.10.1.1 0.00003306 53.0
HFD2_k127_7655104_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 504.0
HFD2_k127_7655104_3 LAO AO transport system K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003669 326.0
HFD2_k127_7655104_4 IstB-like ATP binding protein K02315 - - 0.0000000000000000000000000000000000000000000000000000005765 201.0
HFD2_k127_7655104_5 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000002865 205.0
HFD2_k127_7655104_6 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.00000000000000000000000000000000000002441 154.0
HFD2_k127_7655104_7 toxin-antitoxin pair type II binding - - - 0.000000000000000000003737 94.0
HFD2_k127_7655104_8 - - - - 0.00000000000000005334 88.0
HFD2_k127_7655104_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000002997 55.0
HFD2_k127_7713721_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 4.617e-236 758.0
HFD2_k127_7713721_1 DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000001555 242.0
HFD2_k127_7713721_2 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000002704 168.0
HFD2_k127_7713721_3 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000001236 126.0
HFD2_k127_7713721_4 Iron-sulfur cluster-binding domain - - - 0.000000000000000000009809 104.0
HFD2_k127_782719_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.004e-253 803.0
HFD2_k127_782719_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.052e-201 648.0
HFD2_k127_782719_10 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 0.000000000000000000000000000000000000000000000000000000308 216.0
HFD2_k127_782719_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.0000000000000000000000000000000000000000000009924 189.0
HFD2_k127_782719_12 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000001754 142.0
HFD2_k127_782719_13 Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000002352 129.0
HFD2_k127_782719_14 Metallophosphoesterase - - - 0.00000000000000000000000000001192 121.0
HFD2_k127_782719_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - - 0.000000000000000000000000007021 123.0
HFD2_k127_782719_16 membrane-bound metal-dependent K07038 - - 0.0000000000000000000000006129 119.0
HFD2_k127_782719_17 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000001155 100.0
HFD2_k127_782719_18 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075,K15780 - 2.4.2.8,6.3.4.19 0.000000000000000000001474 106.0
HFD2_k127_782719_19 YbbR-like protein - - - 0.000000000000000000002192 102.0
HFD2_k127_782719_2 Glycine D-amino acid oxidase (deaminating) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 597.0
HFD2_k127_782719_20 response regulator - - - 0.0000000000000000001402 98.0
HFD2_k127_782719_21 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000003779 96.0
HFD2_k127_782719_22 Thioesterase-like superfamily K07107 - - 0.000000000000003458 89.0
HFD2_k127_782719_23 STAS domain K04749 - - 0.0000000000000383 80.0
HFD2_k127_782719_24 Forkhead associated domain - - - 0.0005324 51.0
HFD2_k127_782719_3 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 500.0
HFD2_k127_782719_4 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 439.0
HFD2_k127_782719_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 362.0
HFD2_k127_782719_6 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 331.0
HFD2_k127_782719_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000005231 242.0
HFD2_k127_782719_8 deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000003022 216.0
HFD2_k127_782719_9 metallopeptidase activity K01993,K13408,K16922 - - 0.00000000000000000000000000000000000000000000000000000000004908 231.0
HFD2_k127_7913061_0 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.0 1350.0
HFD2_k127_7913061_1 protein secretion by the type I secretion system K11085 - - 6.228e-206 659.0
HFD2_k127_7913061_10 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 284.0
HFD2_k127_7913061_11 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000004362 255.0
HFD2_k127_7913061_12 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000008572 230.0
HFD2_k127_7913061_13 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000007535 224.0
HFD2_k127_7913061_14 Belongs to the BI1 family K06890,K19416 - - 0.00000000000000000000000000000000000000000000000000000000000001613 222.0
HFD2_k127_7913061_15 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000003564 209.0
HFD2_k127_7913061_16 - - - - 0.000000000000000000000000000000000000000000000000000008938 198.0
HFD2_k127_7913061_17 heme binding K21472 - - 0.0000000000000000000000000000000000000000000000000001598 199.0
HFD2_k127_7913061_18 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000001543 192.0
HFD2_k127_7913061_19 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000001279 186.0
HFD2_k127_7913061_2 ABC1 family K03688 - - 5.248e-198 633.0
HFD2_k127_7913061_20 photosynthesis - - - 0.000000000000000000000000000000000000000000007944 167.0
HFD2_k127_7913061_21 Nitroreductase family - - - 0.00000000000000000000000000000000000000000006546 174.0
HFD2_k127_7913061_22 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000003588 136.0
HFD2_k127_7913061_23 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000002823 114.0
HFD2_k127_7913061_24 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000008198 114.0
HFD2_k127_7913061_26 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000001931 94.0
HFD2_k127_7913061_27 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.0000000000000000002696 99.0
HFD2_k127_7913061_28 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K06378 - - 0.0000000000003049 79.0
HFD2_k127_7913061_3 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 545.0
HFD2_k127_7913061_4 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 432.0
HFD2_k127_7913061_5 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 406.0
HFD2_k127_7913061_6 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 412.0
HFD2_k127_7913061_7 peptidoglycan-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 388.0
HFD2_k127_7913061_8 Serine phosphatase RsbU, regulator of sigma subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 372.0
HFD2_k127_7913061_9 Putative serine dehydratase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 309.0
HFD2_k127_7963659_0 Dehydrogenase E1 component K11381 - 1.2.4.4 4.109e-319 989.0
HFD2_k127_7963659_1 TonB dependent receptor K02014 - - 2.947e-317 997.0
HFD2_k127_7963659_10 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 442.0
HFD2_k127_7963659_11 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 436.0
HFD2_k127_7963659_12 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 382.0
HFD2_k127_7963659_13 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 319.0
HFD2_k127_7963659_14 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 336.0
HFD2_k127_7963659_15 PFAM Rhomboid family protein K07059 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009344 274.0
HFD2_k127_7963659_16 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000627 257.0
HFD2_k127_7963659_17 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002303 254.0
HFD2_k127_7963659_18 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000009626 235.0
HFD2_k127_7963659_19 PFAM Phosphomethylpyrimidine kinase type-1 K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000002601 234.0
HFD2_k127_7963659_2 Lysylphosphatidylglycerol synthase TM region K07027,K14205 - 2.3.2.3 1.687e-278 883.0
HFD2_k127_7963659_20 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000000000000000003467 238.0
HFD2_k127_7963659_21 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000001804 232.0
HFD2_k127_7963659_22 Papain-like cysteine protease AvrRpt2 - - - 0.00000000000000000000000000000000000000000000000000000000000002957 220.0
HFD2_k127_7963659_23 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000001345 214.0
HFD2_k127_7963659_24 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000002217 219.0
HFD2_k127_7963659_25 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000001953 198.0
HFD2_k127_7963659_26 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000002406 190.0
HFD2_k127_7963659_27 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000001911 186.0
HFD2_k127_7963659_28 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000008935 154.0
HFD2_k127_7963659_29 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000002473 147.0
HFD2_k127_7963659_3 Prolyl oligopeptidase K01322 - 3.4.21.26 3.558e-209 672.0
HFD2_k127_7963659_30 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000002997 154.0
HFD2_k127_7963659_31 - - - - 0.000000000000000000000000000463 128.0
HFD2_k127_7963659_32 PFAM response regulator receiver K07657 - - 0.0000000000000000000000000005948 130.0
HFD2_k127_7963659_33 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000006774 121.0
HFD2_k127_7963659_34 sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000001421 118.0
HFD2_k127_7963659_35 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000001251 115.0
HFD2_k127_7963659_36 - - - - 0.000000000000000000004026 104.0
HFD2_k127_7963659_37 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000004792 99.0
HFD2_k127_7963659_38 Protein of unknown function (DUF962) - - - 0.0000000000000000009624 96.0
HFD2_k127_7963659_39 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.000000000000000001535 98.0
HFD2_k127_7963659_4 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 574.0
HFD2_k127_7963659_40 positive regulation of macromolecule biosynthetic process K03973 - - 0.000000000000000006038 85.0
HFD2_k127_7963659_41 Stress-responsive transcriptional regulator - - - 0.00000000000000001622 87.0
HFD2_k127_7963659_42 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000000000035 94.0
HFD2_k127_7963659_43 Bacterial PH domain K08981 - - 0.00000000000000006376 89.0
HFD2_k127_7963659_44 ACT domain - - - 0.000000000000001997 82.0
HFD2_k127_7963659_45 gluconolactonase activity K04771 - 3.4.21.107 0.000000000000002558 87.0
HFD2_k127_7963659_46 Heavy-metal resistance - - - 0.00000000000002526 84.0
HFD2_k127_7963659_47 MerR family transcriptional regulator - - - 0.00000000000005117 83.0
HFD2_k127_7963659_48 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000001141 82.0
HFD2_k127_7963659_5 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 563.0
HFD2_k127_7963659_52 Carboxypeptidase regulatory-like domain - - - 0.0000000001271 74.0
HFD2_k127_7963659_53 Major Facilitator Superfamily - - - 0.000000006568 70.0
HFD2_k127_7963659_54 mRNA catabolic process K06950 - - 0.00000004653 64.0
HFD2_k127_7963659_55 COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain K04771 - 3.4.21.107 0.00000035 63.0
HFD2_k127_7963659_56 Belongs to the HesB IscA family K13628 - - 0.000001497 60.0
HFD2_k127_7963659_57 serine-type endopeptidase activity K04771 - 3.4.21.107 0.00001045 58.0
HFD2_k127_7963659_58 transcriptional regulator, SARP family - - - 0.00006611 55.0
HFD2_k127_7963659_6 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 525.0
HFD2_k127_7963659_60 Sigma-70, region 4 K03088 - - 0.0003768 50.0
HFD2_k127_7963659_7 Bacterial virulence protein (VirJ) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 520.0
HFD2_k127_7963659_8 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 523.0
HFD2_k127_7963659_9 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 522.0
HFD2_k127_8052915_0 ATP dependent DNA ligase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 552.0
HFD2_k127_8052915_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 561.0
HFD2_k127_8052915_10 - - - - 0.00000000000000000000000000000000000007049 151.0
HFD2_k127_8052915_11 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000031 140.0
HFD2_k127_8052915_12 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000005322 124.0
HFD2_k127_8052915_13 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000003567 126.0
HFD2_k127_8052915_2 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 447.0
HFD2_k127_8052915_3 Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 389.0
HFD2_k127_8052915_4 NIPSNAP - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009185 283.0
HFD2_k127_8052915_5 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001017 280.0
HFD2_k127_8052915_6 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009898 246.0
HFD2_k127_8052915_7 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000289 229.0
HFD2_k127_8052915_8 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000001128 218.0
HFD2_k127_8052915_9 - - - - 0.0000000000000000000000000000000000000000000000000000000005378 213.0
HFD2_k127_8194853_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K08348 - 1.17.1.9,1.17.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002887 526.0
HFD2_k127_8194853_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 429.0
HFD2_k127_8194853_2 formate dehydrogenase K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 323.0
HFD2_k127_8194853_3 formate dehydrogenase K00127,K08350 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.0000000000000000000000000000000000000000001073 168.0
HFD2_k127_8194853_4 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000001696 154.0
HFD2_k127_8194853_5 protein involved in formate dehydrogenase formation K02380 - - 0.00000000000000000000000002701 118.0
HFD2_k127_8204073_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.418e-252 814.0
HFD2_k127_8204073_1 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 533.0
HFD2_k127_8204073_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003133 262.0
HFD2_k127_8204073_3 sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000001488 238.0
HFD2_k127_8204073_4 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000005622 216.0
HFD2_k127_8204073_5 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000008113 194.0
HFD2_k127_8204073_6 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000003067 83.0
HFD2_k127_8204073_7 O-Antigen ligase - - - 0.000000616 62.0
HFD2_k127_8204073_8 PFAM Glycosyl transferases group 1 - - - 0.000001704 52.0
HFD2_k127_8204073_9 - - - - 0.0001868 53.0
HFD2_k127_8205964_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1309.0
HFD2_k127_8205964_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1150.0
HFD2_k127_8205964_10 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000006179 169.0
HFD2_k127_8205964_11 Outer membrane efflux protein - - - 0.00000000000000000000000000000002917 144.0
HFD2_k127_8205964_12 Cytochrome c - - - 0.0000000000000000000000000000004502 132.0
HFD2_k127_8205964_13 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000009441 61.0
HFD2_k127_8205964_14 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000006727 48.0
HFD2_k127_8205964_2 PFAM Leukotriene A4 hydrolase, C-terminal - - - 2.785e-223 709.0
HFD2_k127_8205964_3 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 456.0
HFD2_k127_8205964_4 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 316.0
HFD2_k127_8205964_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 305.0
HFD2_k127_8205964_6 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005758 289.0
HFD2_k127_8205964_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000003205 263.0
HFD2_k127_8205964_8 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000006513 276.0
HFD2_k127_8205964_9 cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000004676 239.0
HFD2_k127_82301_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 2640.0
HFD2_k127_82301_1 B12 binding domain K00548 - 2.1.1.13 0.0 1332.0
HFD2_k127_82301_10 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006933 274.0
HFD2_k127_82301_11 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003516 281.0
HFD2_k127_82301_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.000000000000000000000000000000000000000000000000000000000009335 210.0
HFD2_k127_82301_13 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000002938 204.0
HFD2_k127_82301_14 sequence-specific DNA binding K03719 - - 0.00000000000000000000000000000000000000000000000000001359 193.0
HFD2_k127_82301_15 - - - - 0.0000000000000000000000000000000000000000003513 163.0
HFD2_k127_82301_16 DinB family - - - 0.00000000000000000000000000000000000001356 153.0
HFD2_k127_82301_17 heme oxygenase (decyclizing) activity - - - 0.000000000000000000000000001779 117.0
HFD2_k127_82301_18 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000009873 80.0
HFD2_k127_82301_19 - - - - 0.0000000000003448 74.0
HFD2_k127_82301_2 peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 471.0
HFD2_k127_82301_20 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0009772 47.0
HFD2_k127_82301_3 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 479.0
HFD2_k127_82301_4 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 416.0
HFD2_k127_82301_5 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 415.0
HFD2_k127_82301_6 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 362.0
HFD2_k127_82301_7 Iron ABC transporter substrate-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 305.0
HFD2_k127_82301_8 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 300.0
HFD2_k127_82301_9 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 291.0
HFD2_k127_8251792_0 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 1.251e-205 658.0
HFD2_k127_8251792_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 514.0
HFD2_k127_8251792_10 Domain of unknown function (DUF3473) - - - 0.00000000000000000000000000000000000000000002023 172.0
HFD2_k127_8251792_11 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000001839 167.0
HFD2_k127_8251792_12 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000001909 167.0
HFD2_k127_8251792_13 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000001206 170.0
HFD2_k127_8251792_14 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.000000000000000000000000000000000000003379 158.0
HFD2_k127_8251792_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000006715 117.0
HFD2_k127_8251792_16 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000007629 106.0
HFD2_k127_8251792_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000001049 105.0
HFD2_k127_8251792_18 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.0000000000000000001902 98.0
HFD2_k127_8251792_19 plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000001271 91.0
HFD2_k127_8251792_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 496.0
HFD2_k127_8251792_20 Belongs to the anti-sigma-factor antagonist family K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000001744 72.0
HFD2_k127_8251792_21 - - - - 0.00000000006346 75.0
HFD2_k127_8251792_22 - - - - 0.00000002835 66.0
HFD2_k127_8251792_23 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00002294 51.0
HFD2_k127_8251792_24 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity K02372 - 4.2.1.59 0.00004811 53.0
HFD2_k127_8251792_25 sarp family - - - 0.0009749 51.0
HFD2_k127_8251792_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 471.0
HFD2_k127_8251792_4 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 419.0
HFD2_k127_8251792_5 quinone binding K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 356.0
HFD2_k127_8251792_6 formate dehydrogenase (NAD+) activity K00336,K18006 - 1.12.1.2,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 350.0
HFD2_k127_8251792_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 324.0
HFD2_k127_8251792_8 PFAM short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000002867 254.0
HFD2_k127_8251792_9 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000006733 183.0
HFD2_k127_8256300_0 - K12065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 382.0
HFD2_k127_8256300_1 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000004176 154.0
HFD2_k127_8256300_2 PFAM Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000007477 147.0
HFD2_k127_8256300_3 high-affinity ferrous iron transmembrane transporter activity K07243 - - 0.0000000000000000000000000000000000004117 150.0
HFD2_k127_8256300_4 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000003807 132.0
HFD2_k127_8256300_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000009694 121.0
HFD2_k127_8256300_6 - - - - 0.00000615 57.0
HFD2_k127_8263482_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1071.0
HFD2_k127_8263482_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.134e-243 781.0
HFD2_k127_8263482_10 CBS domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009249 285.0
HFD2_k127_8263482_11 GTP binding K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
HFD2_k127_8263482_12 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003778 263.0
HFD2_k127_8263482_13 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004805 265.0
HFD2_k127_8263482_14 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000002072 239.0
HFD2_k127_8263482_15 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000002485 248.0
HFD2_k127_8263482_16 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000236 170.0
HFD2_k127_8263482_17 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000434 147.0
HFD2_k127_8263482_18 NADP oxidoreductase coenzyme F420-dependent - - - 0.0000000000000000000000000001592 126.0
HFD2_k127_8263482_19 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000000000000000000000002427 125.0
HFD2_k127_8263482_2 Heat shock 70 kDa protein K04043 - - 2.708e-235 743.0
HFD2_k127_8263482_20 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000001216 114.0
HFD2_k127_8263482_21 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000001288 119.0
HFD2_k127_8263482_22 Belongs to the ompA family - - - 0.0000000000000000000000003126 108.0
HFD2_k127_8263482_23 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000001983 96.0
HFD2_k127_8263482_24 Modulates RecA activity K03565 - - 0.0000001248 61.0
HFD2_k127_8263482_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.159e-202 651.0
HFD2_k127_8263482_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 525.0
HFD2_k127_8263482_5 Magnesium chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 512.0
HFD2_k127_8263482_6 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 406.0
HFD2_k127_8263482_7 Dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 388.0
HFD2_k127_8263482_8 alpha beta alpha domain I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009524 361.0
HFD2_k127_8263482_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 345.0
HFD2_k127_8278405_0 PFAM Peptidoglycan-binding domain 1 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 513.0
HFD2_k127_8278405_1 COG3497 Phage tail sheath protein FI K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003278 268.0
HFD2_k127_8278405_2 Thiamine-binding protein - - - 0.0000000000000000000000000000000000000001593 156.0
HFD2_k127_8278405_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000002432 131.0
HFD2_k127_8336488_0 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000007736 239.0
HFD2_k127_8336488_1 Involved in galactofuranosyl biosynthesis converts UDO-GlcP to UDP-GalP catalytic activity UDP- glucopyranose UDP-galactopyranose - - - 0.00000000000000000000000000000000000000000000000000000000003599 208.0
HFD2_k127_8336488_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000512 134.0
HFD2_k127_8336488_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000002709 66.0
HFD2_k127_8336488_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0001931 54.0
HFD2_k127_8336488_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0004433 53.0
HFD2_k127_8341055_0 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 361.0
HFD2_k127_8341055_1 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 290.0
HFD2_k127_8341055_2 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 291.0
HFD2_k127_8341055_3 Ferritin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003698 267.0
HFD2_k127_8341055_4 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000422 225.0
HFD2_k127_8341055_5 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000967 210.0
HFD2_k127_8341055_6 Universal stress protein family - - - 0.00000000000000000000000000000006543 131.0
HFD2_k127_8341055_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00000005622 55.0
HFD2_k127_8392528_0 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000002272 258.0
HFD2_k127_8392528_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000005411 234.0
HFD2_k127_8392528_2 TonB-dependent Receptor Plug Domain K16092 - - 0.00000000000000000000000000000000000000000000000000000002625 220.0
HFD2_k127_8392528_3 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000003379 182.0
HFD2_k127_8415230_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 462.0
HFD2_k127_8415230_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000004094 202.0
HFD2_k127_8415230_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000005676 179.0
HFD2_k127_8415230_3 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000001696 158.0
HFD2_k127_8432297_0 ADP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 638.0
HFD2_k127_8432297_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 424.0
HFD2_k127_8432297_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003743 402.0
HFD2_k127_8432297_3 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 332.0
HFD2_k127_8432297_4 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003653 266.0
HFD2_k127_8432297_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000002385 203.0
HFD2_k127_8432297_6 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000001339 134.0
HFD2_k127_84549_0 3-deoxy-7-phosphoheptulonate synthase activity K00661,K03856,K04092,K04093,K04516,K04518,K14170,K14187 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,2.3.1.79,2.5.1.54,4.2.1.51,5.4.99.5 2.961e-203 659.0
HFD2_k127_84549_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 568.0
HFD2_k127_84549_2 Pkd domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 372.0
HFD2_k127_84549_3 transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 345.0
HFD2_k127_84549_4 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000007019 216.0
HFD2_k127_84549_5 transport system, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000001652 218.0
HFD2_k127_84549_6 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000001487 191.0
HFD2_k127_8521904_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 2.194e-253 795.0
HFD2_k127_8521904_1 Molybdopterin oxidoreductase Fe4S4 domain K00372,K00380 - 1.8.1.2 6.933e-231 739.0
HFD2_k127_8522608_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 296.0
HFD2_k127_8522608_1 ATPases associated with a variety of cellular activities K01990,K09689,K09691 - 3.6.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000186 261.0
HFD2_k127_8522608_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000001153 233.0
HFD2_k127_8522608_3 PFAM ABC-2 type transporter K01992,K09690 - - 0.000000000000000000000000000000000000000000005056 174.0
HFD2_k127_8522608_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000002607 183.0
HFD2_k127_8522608_5 Polysaccharide deacetylase - - - 0.0000000000000000000000000004684 133.0
HFD2_k127_8522608_6 Methyltransferase domain - - - 0.0000000000000000000005209 107.0
HFD2_k127_8522608_7 Methyltransferase domain - - - 0.00000000000000000008176 102.0
HFD2_k127_8522608_8 TIGRFAM amino acid adenylation domain - - - 0.000000002013 69.0
HFD2_k127_8542521_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 555.0
HFD2_k127_8542521_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 349.0
HFD2_k127_8542521_10 Adenylate cyclase - - - 0.0000000000000001961 89.0
HFD2_k127_8542521_11 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000004671 80.0
HFD2_k127_8542521_12 histone H2A K63-linked ubiquitination - - - 0.000000000001762 76.0
HFD2_k127_8542521_13 FHA domain K07315 - 3.1.3.3 0.0000000004183 70.0
HFD2_k127_8542521_2 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 320.0
HFD2_k127_8542521_3 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 314.0
HFD2_k127_8542521_4 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002383 261.0
HFD2_k127_8542521_5 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000001241 226.0
HFD2_k127_8542521_6 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000004414 205.0
HFD2_k127_8542521_7 Cupin 2, conserved barrel domain protein K16953,K19547 - 4.4.1.3,5.3.3.19 0.0000000000000000000000000000000707 131.0
HFD2_k127_8542521_8 Domain of unknown function (DUF1772) - - - 0.000000000000000000000005619 106.0
HFD2_k127_8542521_9 Adenylate cyclase - - - 0.000000000000000004714 93.0
HFD2_k127_8543301_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0 1750.0
HFD2_k127_8543301_1 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 5.837e-216 700.0
HFD2_k127_8543301_2 Sodium:sulfate symporter transmembrane region K03319,K09477,K11106,K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 368.0
HFD2_k127_8543301_3 phosphorelay signal transduction system - - - 0.0000000000000000000000000000001401 128.0
HFD2_k127_8543301_4 Family of unknown function (DUF5329) - - - 0.00000000000306 72.0
HFD2_k127_8720673_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 299.0
HFD2_k127_8720673_1 3-demethylubiquinone-9 3-O-methyltransferase activity K20444 - - 0.000000000000000000000000000002058 129.0
HFD2_k127_8720673_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000003115 109.0
HFD2_k127_881430_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695,K03696 - - 0.0 1075.0
HFD2_k127_881430_1 xanthine dehydrogenase activity K04108 - 1.3.7.9 5.263e-299 940.0
HFD2_k127_881430_10 Putative zinc-binding metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008474 512.0
HFD2_k127_881430_100 Ferredoxin K01768,K04755,K11107 - 4.6.1.1 0.00000004287 59.0
HFD2_k127_881430_101 Bacterial membrane protein YfhO - - - 0.00000007062 66.0
HFD2_k127_881430_103 sequence-specific DNA binding K03557,K07712 GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0003371 47.0
HFD2_k127_881430_104 Prokaryotic N-terminal methylation motif - - - 0.0008605 49.0
HFD2_k127_881430_11 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 514.0
HFD2_k127_881430_12 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 519.0
HFD2_k127_881430_13 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 497.0
HFD2_k127_881430_14 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 484.0
HFD2_k127_881430_15 serine-type peptidase activity K01278 - 3.4.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 501.0
HFD2_k127_881430_16 OmpA family K02557,K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 473.0
HFD2_k127_881430_17 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 459.0
HFD2_k127_881430_18 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 443.0
HFD2_k127_881430_19 Dehydrogenase E1 component K00164,K01616 - 1.2.4.2,4.1.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 440.0
HFD2_k127_881430_2 4Fe-4S single cluster domain K06937 - - 3.13e-253 796.0
HFD2_k127_881430_20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009294 434.0
HFD2_k127_881430_21 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 423.0
HFD2_k127_881430_22 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 424.0
HFD2_k127_881430_23 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 422.0
HFD2_k127_881430_24 PFAM Pyridoxal-dependent decarboxylase K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005676 404.0
HFD2_k127_881430_25 Peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 398.0
HFD2_k127_881430_26 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 385.0
HFD2_k127_881430_27 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 341.0
HFD2_k127_881430_28 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009316 347.0
HFD2_k127_881430_29 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 312.0
HFD2_k127_881430_3 GTP-binding protein TypA K06207 - - 2.282e-199 638.0
HFD2_k127_881430_30 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 313.0
HFD2_k127_881430_31 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 295.0
HFD2_k127_881430_32 PFAM Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 305.0
HFD2_k127_881430_33 PFAM Sodium calcium exchanger protein K07300 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 296.0
HFD2_k127_881430_34 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 304.0
HFD2_k127_881430_35 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 317.0
HFD2_k127_881430_36 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002856 298.0
HFD2_k127_881430_37 ABC transporter K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000018 282.0
HFD2_k127_881430_38 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002743 290.0
HFD2_k127_881430_39 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004288 281.0
HFD2_k127_881430_4 Elongator protein 3, MiaB family, Radical SAM - - - 7.461e-194 635.0
HFD2_k127_881430_40 Peptidase M15 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000069 260.0
HFD2_k127_881430_41 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000911 263.0
HFD2_k127_881430_42 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000005848 260.0
HFD2_k127_881430_43 SNARE associated Golgi protein K03975,K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000008923 246.0
HFD2_k127_881430_44 Belongs to the peptidase S1C family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001215 258.0
HFD2_k127_881430_45 PFAM Ribulose-phosphate 3-epimerase K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000001294 249.0
HFD2_k127_881430_46 PFAM Binding-protein-dependent transport system inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000002962 246.0
HFD2_k127_881430_47 PFAM response regulator receiver K07665 - - 0.0000000000000000000000000000000000000000000000000000000000000000001096 241.0
HFD2_k127_881430_48 Cna B domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001161 254.0
HFD2_k127_881430_49 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000518 232.0
HFD2_k127_881430_5 Domain of unknown function (DUF4153) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 600.0
HFD2_k127_881430_50 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000001484 222.0
HFD2_k127_881430_51 Amino-transferase class IV K00824,K00826 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21,2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000008736 232.0
HFD2_k127_881430_52 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000001047 228.0
HFD2_k127_881430_53 Domain of unknown function (DUF4394) - - - 0.0000000000000000000000000000000000000000000000000000000004953 222.0
HFD2_k127_881430_54 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000000000207 196.0
HFD2_k127_881430_55 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000009549 184.0
HFD2_k127_881430_56 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000005114 179.0
HFD2_k127_881430_57 Histidine kinase K07644 - 2.7.13.3 0.000000000000000000000000000000000000000000000008955 191.0
HFD2_k127_881430_58 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000007042 177.0
HFD2_k127_881430_59 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000002992 164.0
HFD2_k127_881430_6 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 597.0
HFD2_k127_881430_60 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000329 169.0
HFD2_k127_881430_61 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000004054 177.0
HFD2_k127_881430_62 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000007809 179.0
HFD2_k127_881430_63 EamA-like transporter family - - - 0.0000000000000000000000000000000000000005402 166.0
HFD2_k127_881430_64 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000002512 161.0
HFD2_k127_881430_65 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000006371 154.0
HFD2_k127_881430_66 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000001059 147.0
HFD2_k127_881430_67 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000004112 148.0
HFD2_k127_881430_68 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000002614 130.0
HFD2_k127_881430_69 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.0000000000000000000000000000000485 138.0
HFD2_k127_881430_7 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 574.0
HFD2_k127_881430_70 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000000000000000000000000000214 145.0
HFD2_k127_881430_71 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000006758 131.0
HFD2_k127_881430_72 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.0000000000000000000000000001767 126.0
HFD2_k127_881430_73 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000006365 123.0
HFD2_k127_881430_74 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000001205 120.0
HFD2_k127_881430_75 RNA recognition motif - - - 0.0000000000000000000000003338 114.0
HFD2_k127_881430_76 phosphotransferase related to Ser Thr protein kinases K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.0000000000000000000000005642 118.0
HFD2_k127_881430_77 Glycosyl transferase, family 2 - - - 0.000000000000000000000002431 121.0
HFD2_k127_881430_78 - - - - 0.00000000000000000000002724 111.0
HFD2_k127_881430_79 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000008569 104.0
HFD2_k127_881430_8 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 559.0
HFD2_k127_881430_80 Smr domain - - - 0.0000000000000000000006567 100.0
HFD2_k127_881430_81 endo-1,4-beta-xylanase activity - - - 0.00000000000000000000303 109.0
HFD2_k127_881430_82 Bacterial membrane protein, YfhO - - - 0.000000000000000000003854 109.0
HFD2_k127_881430_83 COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000005659 98.0
HFD2_k127_881430_84 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.00000000000000000006428 102.0
HFD2_k127_881430_85 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000006546 95.0
HFD2_k127_881430_86 - - - - 0.0000000000000000003891 101.0
HFD2_k127_881430_87 peptidoglycan-binding protein, lysm - - - 0.00000000000000004045 84.0
HFD2_k127_881430_88 Cupin domain - - - 0.000000000000001298 80.0
HFD2_k127_881430_89 redox protein, regulator of disulfide bond formation - - - 0.000000000000002903 83.0
HFD2_k127_881430_9 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 538.0
HFD2_k127_881430_90 Prolyl oligopeptidase family K06889 - - 0.00000000000001043 87.0
HFD2_k127_881430_91 Tellurite resistance protein TerB - - - 0.00000000000002052 79.0
HFD2_k127_881430_92 LysM domain - - - 0.0000000000002937 80.0
HFD2_k127_881430_93 DinB superfamily - - - 0.000000000002235 74.0
HFD2_k127_881430_94 mttA/Hcf106 family K03116 - - 0.000000000003955 68.0
HFD2_k127_881430_95 - - - - 0.0000000001653 69.0
HFD2_k127_881430_96 PASTA K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.0000000004954 70.0
HFD2_k127_881430_97 PPIC-type PPIASE domain - - - 0.000000002874 64.0
HFD2_k127_881430_98 - - - - 0.000000004289 63.0
HFD2_k127_881430_99 chlorophyll binding - - - 0.00000001591 67.0
HFD2_k127_9284_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.178e-288 901.0
HFD2_k127_9284_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.231e-214 680.0
HFD2_k127_9284_2 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001664 287.0
HFD2_k127_9284_3 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000444 287.0
HFD2_k127_9284_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000005883 189.0
HFD2_k127_963199_0 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 1.149e-262 836.0
HFD2_k127_963199_1 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008255 406.0
HFD2_k127_963199_10 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000253 251.0
HFD2_k127_963199_11 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000005701 232.0
HFD2_k127_963199_12 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000007737 238.0
HFD2_k127_963199_13 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000005642 195.0
HFD2_k127_963199_14 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000002838 146.0
HFD2_k127_963199_15 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000001257 145.0
HFD2_k127_963199_16 Cation efflux family - - - 0.00000000000000000001669 99.0
HFD2_k127_963199_17 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000004837 86.0
HFD2_k127_963199_18 Putative Fe-S cluster K00380 - 1.8.1.2 0.00000000000000001661 96.0
HFD2_k127_963199_19 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000004497 79.0
HFD2_k127_963199_2 Zinc-uptake complex component A periplasmic K02077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 353.0
HFD2_k127_963199_20 Belongs to the acetyltransferase family. ArgA subfamily K00619 - 2.3.1.1 0.000000000006677 70.0
HFD2_k127_963199_21 Belongs to the acetyltransferase family. ArgA subfamily K00619 - 2.3.1.1 0.00000002273 56.0
HFD2_k127_963199_22 methyltransferase - - - 0.000002738 58.0
HFD2_k127_963199_23 Domain of unknown function (DUF4149) - - - 0.0003084 50.0
HFD2_k127_963199_3 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 319.0
HFD2_k127_963199_4 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 305.0
HFD2_k127_963199_5 Threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 309.0
HFD2_k127_963199_6 ABC 3 transport family K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 308.0
HFD2_k127_963199_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 304.0
HFD2_k127_963199_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002366 290.0
HFD2_k127_963199_9 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006583 263.0
HFD2_k127_965087_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 530.0
HFD2_k127_965087_1 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 380.0
HFD2_k127_965087_10 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000001114 89.0
HFD2_k127_965087_11 DivIVA protein K04074 - - 0.000000000000000004559 90.0
HFD2_k127_965087_12 integral membrane protein K02221 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000007122 92.0
HFD2_k127_965087_13 C4-type zinc ribbon domain K07164 - - 0.00000000000003662 82.0
HFD2_k127_965087_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 391.0
HFD2_k127_965087_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 322.0
HFD2_k127_965087_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000261 205.0
HFD2_k127_965087_5 transglycosylase K08309 - - 0.0000000000000000000000000005586 132.0
HFD2_k127_965087_6 Methenyltetrahydrofolate cyclohydrolase - - - 0.00000000000000000000000001272 125.0
HFD2_k127_965087_7 Reverse transcriptase-like K03469,K06864 - 3.1.26.4 0.00000000000000000000000001943 115.0
HFD2_k127_965087_8 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000001616 89.0
HFD2_k127_965087_9 nuclear chromosome segregation - - - 0.0000000000000000003355 101.0
HFD2_k127_971386_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 587.0
HFD2_k127_971386_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000001926 184.0
HFD2_k127_971386_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000007705 136.0
HFD2_k127_971386_3 Adenylate cyclase - - - 0.00000000000000000000243 102.0
HFD2_k127_971386_4 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000009533 63.0