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Overview

ID MAG01664
Name HFD2_bin.56
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order UBA5066
Family Gp7-AA6
Genus JAWOLE01
Species
Assembly information
Completeness (%) 87.38
Contamination (%) 0.0
GC content (%) 67.0
N50 (bp) 59,632
Genome size (bp) 4,152,721

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3315

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1014117_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003194 235.0
HFD2_k127_1014117_1 PFAM AhpC TSA family - - - 0.0000000000000000000001368 106.0
HFD2_k127_1014117_2 Periplasmic or secreted lipoprotein - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - 0.000001647 58.0
HFD2_k127_1014632_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1457.0
HFD2_k127_1014632_1 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1295.0
HFD2_k127_1014632_10 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 326.0
HFD2_k127_1014632_11 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009307 292.0
HFD2_k127_1014632_12 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001112 303.0
HFD2_k127_1014632_13 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001421 296.0
HFD2_k127_1014632_14 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000002498 268.0
HFD2_k127_1014632_15 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000115 253.0
HFD2_k127_1014632_16 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002481 250.0
HFD2_k127_1014632_17 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000004528 223.0
HFD2_k127_1014632_18 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000005063 169.0
HFD2_k127_1014632_19 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.000000000000000000000000000000000000000306 151.0
HFD2_k127_1014632_2 POT family K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 537.0
HFD2_k127_1014632_20 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000005966 132.0
HFD2_k127_1014632_21 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000002822 134.0
HFD2_k127_1014632_22 Cytochrome C assembly protein - - - 0.00000000000000000000000704 111.0
HFD2_k127_1014632_23 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.000001102 61.0
HFD2_k127_1014632_3 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 471.0
HFD2_k127_1014632_4 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 447.0
HFD2_k127_1014632_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 444.0
HFD2_k127_1014632_6 Involved in the biosynthesis of porphyrin-containing compound K02495 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 455.0
HFD2_k127_1014632_7 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 447.0
HFD2_k127_1014632_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 383.0
HFD2_k127_1014632_9 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 342.0
HFD2_k127_1018415_0 Involved in the tonB-independent uptake of proteins - - - 2.039e-222 717.0
HFD2_k127_1018415_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000003342 206.0
HFD2_k127_1018415_2 TspO/MBR family K05770 - - 0.000000000000000000000000001293 118.0
HFD2_k127_1018415_3 PFAM RNA recognition motif - - - 0.00000000000000000000000002442 113.0
HFD2_k127_1018415_4 PIN domain - - - 0.000000000000000003776 89.0
HFD2_k127_1051249_0 Flotillin K07192 - - 2.933e-220 691.0
HFD2_k127_1051249_1 serine threonine protein kinase K12132 - 2.7.11.1 8.08e-201 655.0
HFD2_k127_1051249_10 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000000006559 198.0
HFD2_k127_1051249_11 Acyl-transferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000002702 198.0
HFD2_k127_1051249_12 Membrane protein implicated in regulation of membrane protease activity - - - 0.000000000000000000000000000000000000000000000000004208 196.0
HFD2_k127_1051249_13 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000000005587 151.0
HFD2_k127_1051249_14 DinB superfamily - - - 0.00000000000000000000000000000000002543 141.0
HFD2_k127_1051249_15 AhpC/TSA family - - - 0.0000000000000000000000000000000003137 145.0
HFD2_k127_1051249_16 Protein of unknown function (DUF4019) - - - 0.0000000000000000000000000000000054 133.0
HFD2_k127_1051249_17 Protein conserved in bacteria - - - 0.00000000000000000000000000000002891 144.0
HFD2_k127_1051249_18 smart pdz dhr glgf - - - 0.00000000000000000000000000000008135 141.0
HFD2_k127_1051249_19 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides - - - 0.00000000000000000000000000002134 136.0
HFD2_k127_1051249_2 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 364.0
HFD2_k127_1051249_20 YceI-like domain - - - 0.00000000000000000000000000005127 116.0
HFD2_k127_1051249_21 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000001507 115.0
HFD2_k127_1051249_22 calcium- and calmodulin-responsive adenylate cyclase activity K01406 - 3.4.24.40 0.0000000000000000000000001909 114.0
HFD2_k127_1051249_23 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000001373 117.0
HFD2_k127_1051249_24 response regulator - - - 0.000000000000000000004975 103.0
HFD2_k127_1051249_25 PFAM Prenyltransferase squalene oxidase - - - 0.000000000000000001366 100.0
HFD2_k127_1051249_26 - - - - 0.0000000000001056 72.0
HFD2_k127_1051249_27 ABC-type transport system involved in multi-copper enzyme maturation permease component K19341 - - 0.00000000004803 73.0
HFD2_k127_1051249_28 - - - - 0.000001317 62.0
HFD2_k127_1051249_29 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0006108 48.0
HFD2_k127_1051249_3 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 295.0
HFD2_k127_1051249_4 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001094 287.0
HFD2_k127_1051249_5 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001414 296.0
HFD2_k127_1051249_6 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000815 306.0
HFD2_k127_1051249_7 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001008 272.0
HFD2_k127_1051249_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001204 236.0
HFD2_k127_1051249_9 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000009896 220.0
HFD2_k127_1107252_0 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 386.0
HFD2_k127_1107252_1 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.00000000000000000000000000000000000000000000000000000000000000000007023 252.0
HFD2_k127_1107252_2 DNA ligase N terminus K07577,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000001245 219.0
HFD2_k127_1107252_3 Protein kinase domain - - - 0.00000000000000000000000000000000000000000001063 169.0
HFD2_k127_1180558_0 Ferredoxin - - - 0.000000000000000000000000001587 117.0
HFD2_k127_1180558_1 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000002626 126.0
HFD2_k127_1180558_2 Tetratricopeptide repeat - - - 0.000000000000000000000002966 120.0
HFD2_k127_1180558_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000001842 101.0
HFD2_k127_1212956_0 radical SAM domain protein - - - 3.559e-223 703.0
HFD2_k127_1212956_1 Phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 612.0
HFD2_k127_1212956_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 327.0
HFD2_k127_1212956_3 Low affinity iron permease - - - 0.000000000000000000000000000000000000000000000008346 178.0
HFD2_k127_1212956_4 - - - - 0.000000000000001907 80.0
HFD2_k127_1220092_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 3.47e-205 649.0
HFD2_k127_1220092_1 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 634.0
HFD2_k127_1220092_10 diguanylate cyclase - - - 0.0000000006516 68.0
HFD2_k127_1220092_2 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 387.0
HFD2_k127_1220092_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 346.0
HFD2_k127_1220092_4 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003882 266.0
HFD2_k127_1220092_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000004242 130.0
HFD2_k127_1220092_7 Adenylate cyclase - - - 0.00000000000000005092 90.0
HFD2_k127_1220092_8 Pfam SNARE associated Golgi protein - - - 0.00000000004596 72.0
HFD2_k127_1220092_9 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000009285 64.0
HFD2_k127_1241801_0 beta-lactamase - - - 1.786e-234 754.0
HFD2_k127_1241801_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 3.364e-225 708.0
HFD2_k127_1241801_10 PFAM DAHP synthetase I KDSA K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 467.0
HFD2_k127_1241801_11 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007231 468.0
HFD2_k127_1241801_12 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 453.0
HFD2_k127_1241801_13 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 474.0
HFD2_k127_1241801_14 PFAM Cytochrome b b6 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 402.0
HFD2_k127_1241801_15 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 4.2.1.46,4.2.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 415.0
HFD2_k127_1241801_16 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006662 409.0
HFD2_k127_1241801_17 Cytochrome b(C-terminal)/b6/petD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 376.0
HFD2_k127_1241801_18 Coenzyme A transferase K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 350.0
HFD2_k127_1241801_19 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 332.0
HFD2_k127_1241801_2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 1.634e-210 672.0
HFD2_k127_1241801_20 histone deacetylase K11407 - 3.5.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003672 322.0
HFD2_k127_1241801_21 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 343.0
HFD2_k127_1241801_22 CoA-transferase activity K01027,K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 313.0
HFD2_k127_1241801_23 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 308.0
HFD2_k127_1241801_24 PFAM MscS Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001326 256.0
HFD2_k127_1241801_25 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000001512 259.0
HFD2_k127_1241801_26 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000006168 236.0
HFD2_k127_1241801_27 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000001203 240.0
HFD2_k127_1241801_28 Protein of unknown function (DUF2400) - - - 0.00000000000000000000000000000000000000000000000000000000000001098 229.0
HFD2_k127_1241801_29 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000001081 230.0
HFD2_k127_1241801_3 Protein of unknown function, DUF255 K06888 - - 4.428e-204 656.0
HFD2_k127_1241801_30 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774,K22110 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 - 0.00000000000000000000000000000000000000000000000000000000009848 230.0
HFD2_k127_1241801_31 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000000000000000001703 208.0
HFD2_k127_1241801_32 LssY C-terminus - - - 0.00000000000000000000000000000000000000000000000000000006811 212.0
HFD2_k127_1241801_33 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000002204 206.0
HFD2_k127_1241801_34 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000002592 199.0
HFD2_k127_1241801_35 Glucosamine-6-phosphate deaminase K02564 - 3.5.99.6 0.00000000000000000000000000000000000000000000000005143 191.0
HFD2_k127_1241801_36 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000001113 191.0
HFD2_k127_1241801_37 Cytochrome c oxidase subunit III - - - 0.00000000000000000000000000000000000000000000004426 179.0
HFD2_k127_1241801_38 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.0000000000000000000000000000000000000000000001056 186.0
HFD2_k127_1241801_39 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K03478 - 3.5.1.105 0.0000000000000000000000000000000000000000006404 166.0
HFD2_k127_1241801_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 4.013e-201 636.0
HFD2_k127_1241801_40 Prephenate dehydrogenase K00210,K04517 - 1.3.1.12 0.000000000000000000000000000000000000562 150.0
HFD2_k127_1241801_41 PFAM Chorismate mutase of the AroH class K06208 - 5.4.99.5 0.000000000000000000000000000000000002301 148.0
HFD2_k127_1241801_42 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000006138 146.0
HFD2_k127_1241801_43 Neisseria PilC beta-propeller domain K02674 - - 0.0000000000000000000000000000009749 141.0
HFD2_k127_1241801_44 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00172,K00441,K03522 - 1.12.98.1,1.2.7.1 0.0000000000000000000000003655 111.0
HFD2_k127_1241801_45 DinB superfamily - - - 0.0000000000000000000000005474 118.0
HFD2_k127_1241801_46 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000001811 117.0
HFD2_k127_1241801_47 Thioredoxin - - - 0.0000000000000000000001185 111.0
HFD2_k127_1241801_48 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000008952 98.0
HFD2_k127_1241801_49 Thioredoxin-like - - - 0.00000000000000000004949 104.0
HFD2_k127_1241801_5 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 584.0
HFD2_k127_1241801_50 Bacterial membrane protein YfhO - - - 0.0000000000000001589 92.0
HFD2_k127_1241801_51 Peptidase M56 - - - 0.00000000000001779 85.0
HFD2_k127_1241801_52 Biotin-requiring enzyme - - - 0.0000000000005965 79.0
HFD2_k127_1241801_53 bacteriochlorophyll K04040 - 2.5.1.133,2.5.1.62 0.00000000000129 80.0
HFD2_k127_1241801_54 PFAM DSBA-like thioredoxin domain - - - 0.0000003315 63.0
HFD2_k127_1241801_55 PFAM PBS lyase HEAT domain protein repeat-containing protein K02288 - 4.4.1.32 0.0000008224 61.0
HFD2_k127_1241801_56 Tetratricopeptide TPR_2 repeat protein - - - 0.00001926 56.0
HFD2_k127_1241801_57 Protein of unknown function (DUF507) K09804 - - 0.00002545 50.0
HFD2_k127_1241801_58 PFAM Peptidase M20 K01436 - - 0.00005057 48.0
HFD2_k127_1241801_59 Tetratricopeptide repeat - - - 0.0000762 56.0
HFD2_k127_1241801_6 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 517.0
HFD2_k127_1241801_60 modulator of DNA gyrase K03592 - - 0.00008091 55.0
HFD2_k127_1241801_61 PFAM phosphatidate cytidylyltransferase - - - 0.0001262 54.0
HFD2_k127_1241801_7 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 501.0
HFD2_k127_1241801_8 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005764 465.0
HFD2_k127_1241801_9 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 491.0
HFD2_k127_1252826_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.565e-199 649.0
HFD2_k127_1252826_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 607.0
HFD2_k127_1252826_2 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 344.0
HFD2_k127_130059_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13924 - 2.1.1.80,3.1.1.61 2.812e-280 921.0
HFD2_k127_130059_1 IgA Peptidase M64 - - - 1.325e-221 695.0
HFD2_k127_130059_11 GIY-YIG catalytic domain - - - 0.00000000000000003022 81.0
HFD2_k127_130059_12 Serine aminopeptidase, S33 - - - 0.00000000000003137 83.0
HFD2_k127_130059_13 Forkhead associated domain - - - 0.000000004314 67.0
HFD2_k127_130059_14 Endonuclease containing a URI domain K07461 - - 0.0000000239 55.0
HFD2_k127_130059_2 Peptidase family M13 K07386 - - 7.377e-217 694.0
HFD2_k127_130059_3 B12 binding domain - - - 6.557e-215 687.0
HFD2_k127_130059_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 467.0
HFD2_k127_130059_5 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 451.0
HFD2_k127_130059_6 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003715 260.0
HFD2_k127_130059_7 - - - - 0.000000000000000000000000000000000000000000000000000002423 202.0
HFD2_k127_130059_8 Zinc carboxypeptidase K14054 - - 0.000000000000000000000000000000000000000000003184 171.0
HFD2_k127_130059_9 Kdo2-lipid A biosynthetic process K02517,K20543,K22311 - 2.3.1.241,2.3.1.265 0.00000000000000000000196 109.0
HFD2_k127_133571_0 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.0 1395.0
HFD2_k127_133571_1 PFAM BNR Asp-box repeat - - - 3.561e-271 869.0
HFD2_k127_133571_10 Cytochrome b/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 295.0
HFD2_k127_133571_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000007417 229.0
HFD2_k127_133571_12 TatD family K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000201 223.0
HFD2_k127_133571_13 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000007208 229.0
HFD2_k127_133571_14 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000001456 214.0
HFD2_k127_133571_15 - - - - 0.000000000000000000000000000000000000000000000000000002416 200.0
HFD2_k127_133571_16 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000008602 200.0
HFD2_k127_133571_17 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000002242 191.0
HFD2_k127_133571_18 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000366 185.0
HFD2_k127_133571_19 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000006132 156.0
HFD2_k127_133571_2 transcription factor binding K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 595.0
HFD2_k127_133571_20 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000002381 145.0
HFD2_k127_133571_21 STAS domain K04749 - - 0.000000000000000000000000000000005176 132.0
HFD2_k127_133571_22 Zn peptidase - - - 0.00000000000000000000000000001521 132.0
HFD2_k127_133571_23 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000007347 115.0
HFD2_k127_133571_24 TonB dependent receptor K02014 - - 0.0000000000000000000000006044 122.0
HFD2_k127_133571_25 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.000000000000000000000003024 117.0
HFD2_k127_133571_26 Regulatory protein MarR - - - 0.00000000000000000000002977 107.0
HFD2_k127_133571_27 Zincin-like metallopeptidase - - - 0.0000000000000000000001208 103.0
HFD2_k127_133571_28 Electron transfer DM13 - - - 0.00000000000000000001177 102.0
HFD2_k127_133571_29 Protein of unknown function (DUF2905) - - - 0.00000000000000006554 82.0
HFD2_k127_133571_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 590.0
HFD2_k127_133571_31 Toxic component of a toxin-antitoxin (TA) module. An RNase - GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - 0.0000000002482 68.0
HFD2_k127_133571_32 Bacterial antitoxin of type II TA system, VapB - - - 0.000000001775 61.0
HFD2_k127_133571_33 - - - - 0.0000003362 56.0
HFD2_k127_133571_35 CAAX protease self-immunity K07052 - - 0.0001967 53.0
HFD2_k127_133571_4 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 501.0
HFD2_k127_133571_5 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 430.0
HFD2_k127_133571_6 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 382.0
HFD2_k127_133571_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 362.0
HFD2_k127_133571_8 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000914 306.0
HFD2_k127_133571_9 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 306.0
HFD2_k127_1355843_0 MacB-like periplasmic core domain - - - 6.477e-242 784.0
HFD2_k127_1355843_1 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 626.0
HFD2_k127_1355843_10 DoxX K15977 - - 0.00000000000000000000000000000001039 138.0
HFD2_k127_1355843_11 PFAM YCII-related - - - 0.00000000000000000000000000008032 120.0
HFD2_k127_1355843_12 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000003882 83.0
HFD2_k127_1355843_13 endoribonuclease L-PSP - - - 0.0000003116 53.0
HFD2_k127_1355843_2 DNA primase, small subunit K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 581.0
HFD2_k127_1355843_3 ATP dependent DNA ligase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 548.0
HFD2_k127_1355843_4 belongs to the sigma-70 factor family K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 452.0
HFD2_k127_1355843_5 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 420.0
HFD2_k127_1355843_6 D-arabinono-1,4-lactone oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007162 303.0
HFD2_k127_1355843_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000000001036 196.0
HFD2_k127_1355843_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000009776 194.0
HFD2_k127_1355843_9 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000986 191.0
HFD2_k127_1390957_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 8.952e-293 919.0
HFD2_k127_1390957_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 550.0
HFD2_k127_1390957_10 Phosphoglycerate mutase family - - - 0.0000000000000004311 84.0
HFD2_k127_1390957_11 PFAM Uncharacterised BCR, COG1649 - - - 0.00006212 48.0
HFD2_k127_1390957_2 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 392.0
HFD2_k127_1390957_3 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001293 296.0
HFD2_k127_1390957_4 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006809 288.0
HFD2_k127_1390957_5 PFAM LemA family protein K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000002437 233.0
HFD2_k127_1390957_6 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000006998 199.0
HFD2_k127_1390957_7 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000001702 191.0
HFD2_k127_1390957_8 TPM domain - - - 0.000000000000000000000000000000000000008259 162.0
HFD2_k127_1390957_9 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000001689 113.0
HFD2_k127_1499370_0 Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 625.0
HFD2_k127_1499370_1 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 604.0
HFD2_k127_1499370_10 Methionine biosynthesis protein MetW - - - 0.000000000000000000004004 101.0
HFD2_k127_1499370_11 Phospholipase_D-nuclease N-terminal - - - 0.000000002533 60.0
HFD2_k127_1499370_2 Aminotransferase K14267,K14287 - 2.6.1.17,2.6.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 480.0
HFD2_k127_1499370_3 Cys/Met metabolism PLP-dependent enzyme K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 393.0
HFD2_k127_1499370_4 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 363.0
HFD2_k127_1499370_5 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 327.0
HFD2_k127_1499370_6 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 288.0
HFD2_k127_1499370_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005398 295.0
HFD2_k127_1499370_8 proteolysis - - - 0.0000000000000000000000000000009076 132.0
HFD2_k127_1499370_9 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000351 114.0
HFD2_k127_175981_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 4.487e-308 967.0
HFD2_k127_175981_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 601.0
HFD2_k127_175981_2 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 353.0
HFD2_k127_175981_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001331 244.0
HFD2_k127_175981_4 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000003156 229.0
HFD2_k127_175981_5 Single Cache domain 2 K03406 - - 0.000000000000000000000000000000000000000000000000000000003096 204.0
HFD2_k127_175981_6 Transcriptional regulatory protein, C terminal - - - 0.000000000007159 74.0
HFD2_k127_1796743_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 528.0
HFD2_k127_1797141_0 cellulose binding - - - 0.0 1225.0
HFD2_k127_1797141_1 competence protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000787 232.0
HFD2_k127_1797141_2 PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase K07258 - 3.4.16.4 0.00000000000000000000000000000000000000005579 163.0
HFD2_k127_1797141_3 PIN domain - - - 0.000000000000000000000000001461 116.0
HFD2_k127_1797141_4 Fungalysin metallopeptidase (M36) K01417 - - 0.00000000000000000000000003907 115.0
HFD2_k127_1797141_5 Predicted periplasmic lipoprotein (DUF2279) - - - 0.000000000000006583 87.0
HFD2_k127_1797141_6 Protein kinase domain K12132 - 2.7.11.1 0.000000000000009866 75.0
HFD2_k127_1797141_7 SpoVT / AbrB like domain - - - 0.00000000001736 75.0
HFD2_k127_1804925_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 543.0
HFD2_k127_1804925_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 488.0
HFD2_k127_1804925_10 transferase activity, transferring glycosyl groups K00754 - - 0.00000000000000000000000001012 124.0
HFD2_k127_1804925_11 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000008074 72.0
HFD2_k127_1804925_12 Cell division protein ZapA K09888 - - 0.00000000001283 68.0
HFD2_k127_1804925_13 histone H2A K63-linked ubiquitination - - - 0.00000000003566 72.0
HFD2_k127_1804925_14 Transcriptional regulatory protein, C terminal - - - 0.000000000295 69.0
HFD2_k127_1804925_15 Belongs to the UPF0434 family K09791 - - 0.000006419 57.0
HFD2_k127_1804925_2 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 316.0
HFD2_k127_1804925_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K03797 - 3.1.11.6,3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 321.0
HFD2_k127_1804925_4 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001407 279.0
HFD2_k127_1804925_5 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000003093 262.0
HFD2_k127_1804925_6 Psort location Cytoplasmic, score K00008,K00060 - 1.1.1.103,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000004045 245.0
HFD2_k127_1804925_7 involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000004445 230.0
HFD2_k127_1804925_8 cellulose binding - - - 0.000000000000000000000000000000000000001771 168.0
HFD2_k127_1804925_9 O-Antigen ligase K18814 - - 0.0000000000000000000000000002789 129.0
HFD2_k127_1831125_0 imidazolonepropionase activity K01443 - 3.5.1.25 1.646e-218 711.0
HFD2_k127_1831125_1 Prolyl oligopeptidase family - - - 9.643e-198 637.0
HFD2_k127_1831125_10 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000006024 200.0
HFD2_k127_1831125_11 - - - - 0.0000000000000000000000000000000000000008634 155.0
HFD2_k127_1831125_12 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 0.0000000000000000000000000000005833 127.0
HFD2_k127_1831125_13 Protein of unknown function (DUF2911) - - - 0.0000000000000000002683 98.0
HFD2_k127_1831125_15 cellulose binding - - - 0.000000002045 71.0
HFD2_k127_1831125_16 TonB-dependent Receptor Plug K02014 - - 0.0000002692 53.0
HFD2_k127_1831125_2 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 486.0
HFD2_k127_1831125_3 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 439.0
HFD2_k127_1831125_4 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 388.0
HFD2_k127_1831125_5 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 338.0
HFD2_k127_1831125_6 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000566 309.0
HFD2_k127_1831125_7 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006635 257.0
HFD2_k127_1831125_8 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000001133 231.0
HFD2_k127_1831125_9 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000002738 203.0
HFD2_k127_1848373_0 OPT oligopeptide transporter protein - - - 2.696e-320 1000.0
HFD2_k127_1848373_1 Carboxypeptidase regulatory-like domain - - - 8.844e-315 993.0
HFD2_k127_1848373_10 PFAM Thermolysin metallopeptidase, alpha-helical domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 445.0
HFD2_k127_1848373_11 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 460.0
HFD2_k127_1848373_12 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 426.0
HFD2_k127_1848373_13 PFAM Rieske 2Fe-2S domain protein K00479,K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009436 412.0
HFD2_k127_1848373_14 amino acid K03294,K13868 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 392.0
HFD2_k127_1848373_15 PFAM Alpha beta hydrolase K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 349.0
HFD2_k127_1848373_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 362.0
HFD2_k127_1848373_17 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 327.0
HFD2_k127_1848373_18 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002263 254.0
HFD2_k127_1848373_19 TIGRFAM Methylglyoxal synthase K01734 - 4.2.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000001076 242.0
HFD2_k127_1848373_2 Angiotensin-converting enzyme K01283 - 3.4.15.1 4.595e-303 938.0
HFD2_k127_1848373_20 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000006963 233.0
HFD2_k127_1848373_21 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003962 231.0
HFD2_k127_1848373_23 DNA-templated transcription, initiation K03088,K07263 - - 0.0000000000000000000000000000000000000000005436 164.0
HFD2_k127_1848373_24 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000002244 151.0
HFD2_k127_1848373_25 - - - - 0.0000000000000000000000000000000003789 137.0
HFD2_k127_1848373_26 - - - - 0.000000000000000000000000000000001224 137.0
HFD2_k127_1848373_29 agmatine deiminase activity K10536 - 3.5.3.12 0.000000000000002845 83.0
HFD2_k127_1848373_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.259e-199 630.0
HFD2_k127_1848373_30 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000001548 87.0
HFD2_k127_1848373_31 - - - - 0.000000000002456 72.0
HFD2_k127_1848373_32 DNA-binding transcription factor activity K18996 - - 0.00000000005801 67.0
HFD2_k127_1848373_33 RyR domain - - - 0.0000000007545 60.0
HFD2_k127_1848373_34 PFAM blue (type 1) copper domain protein - - - 0.0000002186 59.0
HFD2_k127_1848373_35 Ami_3 K01448 - 3.5.1.28 0.00001109 55.0
HFD2_k127_1848373_4 RNB K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 614.0
HFD2_k127_1848373_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 603.0
HFD2_k127_1848373_6 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 546.0
HFD2_k127_1848373_7 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 498.0
HFD2_k127_1848373_9 secondary active sulfate transmembrane transporter activity K06901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 456.0
HFD2_k127_1852305_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1327.0
HFD2_k127_1852305_1 Protein export membrane protein K03296,K18138 - - 0.0 1244.0
HFD2_k127_1852305_10 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 3.689e-196 627.0
HFD2_k127_1852305_11 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 577.0
HFD2_k127_1852305_12 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 547.0
HFD2_k127_1852305_13 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 464.0
HFD2_k127_1852305_14 surface antigen variable number repeat protein K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 469.0
HFD2_k127_1852305_15 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009635 428.0
HFD2_k127_1852305_16 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 432.0
HFD2_k127_1852305_17 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 421.0
HFD2_k127_1852305_18 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 412.0
HFD2_k127_1852305_19 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 387.0
HFD2_k127_1852305_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1078.0
HFD2_k127_1852305_20 Sodium calcium exchanger membrane K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 391.0
HFD2_k127_1852305_21 Biotin-lipoyl like K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 375.0
HFD2_k127_1852305_22 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 364.0
HFD2_k127_1852305_23 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 341.0
HFD2_k127_1852305_24 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 323.0
HFD2_k127_1852305_25 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 311.0
HFD2_k127_1852305_26 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 299.0
HFD2_k127_1852305_27 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 294.0
HFD2_k127_1852305_28 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005865 306.0
HFD2_k127_1852305_29 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001996 274.0
HFD2_k127_1852305_3 Polysulphide reductase, NrfD K00124 - - 9.32e-304 959.0
HFD2_k127_1852305_30 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001757 277.0
HFD2_k127_1852305_31 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008285 282.0
HFD2_k127_1852305_32 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003589 260.0
HFD2_k127_1852305_33 Necessary for formate dehydrogenase activity K02380 - - 0.0000000000000000000000000000000000000000000000000000000000000000005284 239.0
HFD2_k127_1852305_34 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000001998 232.0
HFD2_k127_1852305_35 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000002699 254.0
HFD2_k127_1852305_36 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000001177 209.0
HFD2_k127_1852305_37 membrane - - - 0.0000000000000000000000000000000000000000000000000000007628 202.0
HFD2_k127_1852305_4 SMART Elongator protein 3 MiaB NifB - - - 1.878e-221 695.0
HFD2_k127_1852305_40 - - - - 0.0000000000000000000000000000000000000000001858 175.0
HFD2_k127_1852305_41 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000002474 170.0
HFD2_k127_1852305_42 Ion transport 2 domain protein - - - 0.000000000000000000000000000000000000000006658 163.0
HFD2_k127_1852305_43 EamA-like transporter family - - - 0.000000000000000000000000000000000000000009264 166.0
HFD2_k127_1852305_44 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000000000002593 161.0
HFD2_k127_1852305_45 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000407 149.0
HFD2_k127_1852305_46 methyltransferase activity - - - 0.00000000000000000000000000000000009236 146.0
HFD2_k127_1852305_47 YMGG-like Gly-zipper - - - 0.00000000000000000000000000000007318 132.0
HFD2_k127_1852305_49 enzyme binding K00567,K07443 - 2.1.1.63 0.0000000000000000000000000000003074 126.0
HFD2_k127_1852305_5 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 8.342e-215 677.0
HFD2_k127_1852305_50 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000003544 128.0
HFD2_k127_1852305_51 Domain of unknown function (DUF4136) - - - 0.000000000000000000000000000006224 125.0
HFD2_k127_1852305_52 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.000000000000000000000000003567 123.0
HFD2_k127_1852305_53 Cupredoxin-like domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.0000000000000000000000003662 123.0
HFD2_k127_1852305_54 cheY-homologous receiver domain - - - 0.000000000000000000000001568 109.0
HFD2_k127_1852305_55 Polysaccharide biosynthesis protein - - - 0.00000000000000000000004697 116.0
HFD2_k127_1852305_56 phosphorelay signal transduction system K14987 - - 0.0000000000000000000000523 107.0
HFD2_k127_1852305_57 Glycosyl transferase, family 2 - - - 0.0000000000000000000001309 113.0
HFD2_k127_1852305_58 - - - - 0.000000000000000000003927 100.0
HFD2_k127_1852305_59 Predicted periplasmic lipoprotein (DUF2279) - - - 0.00000000000003116 85.0
HFD2_k127_1852305_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 4.036e-212 687.0
HFD2_k127_1852305_60 Domain of unknown function (DUF4136) - - - 0.0000000004956 70.0
HFD2_k127_1852305_7 Sulfate permease family - - - 1.136e-210 683.0
HFD2_k127_1852305_8 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 4.468e-208 655.0
HFD2_k127_1852305_9 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.055e-201 644.0
HFD2_k127_1904532_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.06e-268 852.0
HFD2_k127_1904532_1 Elongation factor G, domain IV K02355 - - 5.552e-205 658.0
HFD2_k127_1904532_10 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 372.0
HFD2_k127_1904532_11 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006433 355.0
HFD2_k127_1904532_12 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 334.0
HFD2_k127_1904532_13 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 302.0
HFD2_k127_1904532_14 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 313.0
HFD2_k127_1904532_15 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002281 281.0
HFD2_k127_1904532_16 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000011 284.0
HFD2_k127_1904532_17 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000003347 288.0
HFD2_k127_1904532_18 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003408 265.0
HFD2_k127_1904532_19 Glycogen debranching enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001117 278.0
HFD2_k127_1904532_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 610.0
HFD2_k127_1904532_20 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001028 270.0
HFD2_k127_1904532_21 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007927 243.0
HFD2_k127_1904532_22 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002093 242.0
HFD2_k127_1904532_23 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000002083 216.0
HFD2_k127_1904532_24 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000007427 210.0
HFD2_k127_1904532_25 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000003298 205.0
HFD2_k127_1904532_26 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000343 205.0
HFD2_k127_1904532_27 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000005842 193.0
HFD2_k127_1904532_28 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000003312 184.0
HFD2_k127_1904532_29 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000002548 182.0
HFD2_k127_1904532_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 568.0
HFD2_k127_1904532_30 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000004725 181.0
HFD2_k127_1904532_31 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000003421 175.0
HFD2_k127_1904532_32 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000009363 175.0
HFD2_k127_1904532_33 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001012 160.0
HFD2_k127_1904532_34 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000001409 160.0
HFD2_k127_1904532_35 Forms part of the polypeptide exit tunnel K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000006388 160.0
HFD2_k127_1904532_36 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000003892 146.0
HFD2_k127_1904532_37 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000002258 138.0
HFD2_k127_1904532_38 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000003786 138.0
HFD2_k127_1904532_39 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000004796 135.0
HFD2_k127_1904532_4 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 588.0
HFD2_k127_1904532_40 oxidoreductase activity - - - 0.000000000000000000000000000005972 138.0
HFD2_k127_1904532_41 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.00000000000000000000000000007515 130.0
HFD2_k127_1904532_42 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000003104 114.0
HFD2_k127_1904532_43 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000001263 119.0
HFD2_k127_1904532_44 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000004098 110.0
HFD2_k127_1904532_45 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000002669 97.0
HFD2_k127_1904532_46 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000001653 89.0
HFD2_k127_1904532_47 Phage integrase family - - - 0.000000000000000000512 90.0
HFD2_k127_1904532_48 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000001798 76.0
HFD2_k127_1904532_49 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000002566 67.0
HFD2_k127_1904532_5 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 552.0
HFD2_k127_1904532_50 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000242 71.0
HFD2_k127_1904532_52 Protein tyrosine kinase K12132 - 2.7.11.1 0.000003223 60.0
HFD2_k127_1904532_53 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000005668 59.0
HFD2_k127_1904532_54 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00002651 54.0
HFD2_k127_1904532_55 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00004885 56.0
HFD2_k127_1904532_56 tetratricopeptide repeat - - - 0.0002861 52.0
HFD2_k127_1904532_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 511.0
HFD2_k127_1904532_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 429.0
HFD2_k127_1904532_8 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009448 408.0
HFD2_k127_1904532_9 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 388.0
HFD2_k127_1962589_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 621.0
HFD2_k127_1962589_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 383.0
HFD2_k127_1962589_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000004476 173.0
HFD2_k127_1962589_3 nuclease activity - - - 0.0000000000000000000000000000000002898 138.0
HFD2_k127_1962589_4 thiolester hydrolase activity K06889 - - 0.000000000000000001329 98.0
HFD2_k127_1962589_5 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000002451 70.0
HFD2_k127_1969303_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 6.927e-296 923.0
HFD2_k127_1969303_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.043e-240 758.0
HFD2_k127_1969303_10 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 408.0
HFD2_k127_1969303_11 protein-disulfide reductase activity K04084,K06196 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 392.0
HFD2_k127_1969303_12 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 371.0
HFD2_k127_1969303_13 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 349.0
HFD2_k127_1969303_14 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 358.0
HFD2_k127_1969303_15 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 344.0
HFD2_k127_1969303_16 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 355.0
HFD2_k127_1969303_17 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 316.0
HFD2_k127_1969303_18 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 326.0
HFD2_k127_1969303_19 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 316.0
HFD2_k127_1969303_2 Involved in the tonB-independent uptake of proteins - - - 3.202e-203 661.0
HFD2_k127_1969303_20 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 306.0
HFD2_k127_1969303_21 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002109 297.0
HFD2_k127_1969303_22 ABC transporter, permease protein K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001566 265.0
HFD2_k127_1969303_23 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001977 259.0
HFD2_k127_1969303_24 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K03148,K21029 - 2.7.7.73,2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000002363 263.0
HFD2_k127_1969303_25 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002404 252.0
HFD2_k127_1969303_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000001456 234.0
HFD2_k127_1969303_27 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000001522 237.0
HFD2_k127_1969303_28 maltose O-acetyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000003457 245.0
HFD2_k127_1969303_29 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000005355 234.0
HFD2_k127_1969303_3 Prolyl oligopeptidase family - - - 1.913e-194 635.0
HFD2_k127_1969303_30 pfam abc K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000008725 242.0
HFD2_k127_1969303_31 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000001561 234.0
HFD2_k127_1969303_32 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000007083 234.0
HFD2_k127_1969303_33 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 0.000000000000000000000000000000000000000000000000000000008988 220.0
HFD2_k127_1969303_34 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000004049 201.0
HFD2_k127_1969303_35 PFAM GTP cyclohydrolase I Nitrile oxidoreductase K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000009841 199.0
HFD2_k127_1969303_36 HlyD family secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000006442 209.0
HFD2_k127_1969303_37 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000001037 207.0
HFD2_k127_1969303_38 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000001113 196.0
HFD2_k127_1969303_39 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000007286 198.0
HFD2_k127_1969303_4 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 594.0
HFD2_k127_1969303_40 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000004271 181.0
HFD2_k127_1969303_41 Lumazine binding domain K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000009125 169.0
HFD2_k127_1969303_42 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.0000000000000000000000000000000000000001103 156.0
HFD2_k127_1969303_43 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000002227 165.0
HFD2_k127_1969303_44 Molybdopterin oxidoreductase - - - 0.0000000000000000000000000000000000000005579 156.0
HFD2_k127_1969303_45 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000002569 162.0
HFD2_k127_1969303_46 required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.7.7.87 0.000000000000000000000000000000001576 138.0
HFD2_k127_1969303_47 Serine phosphatase RsbU regulator of sigma subunit K07315 - 3.1.3.3 0.000000000000000000000000000008513 133.0
HFD2_k127_1969303_48 protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000001205 127.0
HFD2_k127_1969303_49 TIGRFAM TonB K03832 - - 0.00000000000000000000000002379 118.0
HFD2_k127_1969303_5 PHP domain protein K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 535.0
HFD2_k127_1969303_50 Peptidase family M28 - - - 0.00000000000000000000000006717 123.0
HFD2_k127_1969303_51 Tetratricopeptide repeat - - - 0.00000000000000000000000022 119.0
HFD2_k127_1969303_52 oxidoreductase activity - - - 0.00000000000000000000001802 116.0
HFD2_k127_1969303_53 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000000000000003117 101.0
HFD2_k127_1969303_54 Glutathione peroxidase - - - 0.000000000000000000001102 109.0
HFD2_k127_1969303_55 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000001502 99.0
HFD2_k127_1969303_56 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000003941 91.0
HFD2_k127_1969303_57 Tetratricopeptide repeat - - - 0.000000003263 70.0
HFD2_k127_1969303_58 Belongs to the 'phage' integrase family - - - 0.0000000231 64.0
HFD2_k127_1969303_59 Outer membrane protein beta-barrel domain - - - 0.0000002155 61.0
HFD2_k127_1969303_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002174 513.0
HFD2_k127_1969303_60 COG3764 Sortase (surface protein transpeptidase) K07284 - 3.4.22.70 0.0000002539 60.0
HFD2_k127_1969303_61 Bacterial regulatory proteins, tetR family - - - 0.0000004142 59.0
HFD2_k127_1969303_63 antisigma factor binding K03598 - - 0.00000715 56.0
HFD2_k127_1969303_64 Protein of unknown function, DUF255 - - - 0.000009409 57.0
HFD2_k127_1969303_66 Protein of unknown function with HXXEE motif - - - 0.0000755 52.0
HFD2_k127_1969303_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 478.0
HFD2_k127_1969303_8 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 460.0
HFD2_k127_1969303_9 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 403.0
HFD2_k127_2028025_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1305.0
HFD2_k127_2028025_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1132.0
HFD2_k127_2028025_10 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 559.0
HFD2_k127_2028025_11 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 498.0
HFD2_k127_2028025_12 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006501 471.0
HFD2_k127_2028025_13 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 419.0
HFD2_k127_2028025_14 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 419.0
HFD2_k127_2028025_15 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004508 432.0
HFD2_k127_2028025_16 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 430.0
HFD2_k127_2028025_17 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 398.0
HFD2_k127_2028025_18 DegT/DnrJ/EryC1/StrS aminotransferase family K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 384.0
HFD2_k127_2028025_19 PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009442 385.0
HFD2_k127_2028025_2 Belongs to the peptidase M16 family K07263 - - 0.0 1131.0
HFD2_k127_2028025_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 389.0
HFD2_k127_2028025_21 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 387.0
HFD2_k127_2028025_22 Acetamidase formamidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 345.0
HFD2_k127_2028025_23 TOBE domain K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009395 342.0
HFD2_k127_2028025_24 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 344.0
HFD2_k127_2028025_25 Transmembrane secretion effector K08225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 319.0
HFD2_k127_2028025_26 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 329.0
HFD2_k127_2028025_27 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002801 295.0
HFD2_k127_2028025_28 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004142 256.0
HFD2_k127_2028025_29 Bacterial extracellular solute-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000001553 235.0
HFD2_k127_2028025_3 WD40 domain protein beta Propeller K12132 - 2.7.11.1 3.532e-244 782.0
HFD2_k127_2028025_30 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001136 240.0
HFD2_k127_2028025_31 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000004576 235.0
HFD2_k127_2028025_32 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000053 205.0
HFD2_k127_2028025_33 PFAM EAL domain - - - 0.00000000000000000000000000000000000000000000000894 192.0
HFD2_k127_2028025_35 ABC-type multidrug transport system ATPase K01990 - - 0.000000000000000000000000000000000000005172 158.0
HFD2_k127_2028025_36 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000001468 149.0
HFD2_k127_2028025_37 diguanylate cyclase - - - 0.00000000000000000000000000000362 135.0
HFD2_k127_2028025_38 Transcriptional regulator K02019 - - 0.0000000000000000000000003655 111.0
HFD2_k127_2028025_39 - - - - 0.00000000000000000000003734 105.0
HFD2_k127_2028025_4 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 6.672e-241 765.0
HFD2_k127_2028025_40 helix_turn_helix, mercury resistance - - - 0.000000000000000000001289 100.0
HFD2_k127_2028025_41 PhoQ Sensor - - - 0.000000000000000000002673 107.0
HFD2_k127_2028025_42 Response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000005658 105.0
HFD2_k127_2028025_43 - - - - 0.00000000000000002919 89.0
HFD2_k127_2028025_44 Adenylate cyclase - - - 0.00000000000000004095 89.0
HFD2_k127_2028025_45 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000001275 76.0
HFD2_k127_2028025_46 Autotransporter beta-domain - - - 0.000000000001262 83.0
HFD2_k127_2028025_48 Protein of unknown function (DUF2662) - - - 0.000000000008519 74.0
HFD2_k127_2028025_49 DNA-templated transcription, initiation K03088 - - 0.000001657 51.0
HFD2_k127_2028025_5 Involved in the tonB-independent uptake of proteins - - - 2.292e-224 725.0
HFD2_k127_2028025_50 Predicted membrane protein (DUF2127) - - - 0.00002059 54.0
HFD2_k127_2028025_6 Involved in the tonB-independent uptake of proteins - - - 2.248e-223 724.0
HFD2_k127_2028025_7 Protein tyrosine kinase K12132 - 2.7.11.1 1.415e-211 692.0
HFD2_k127_2028025_8 Involved in the tonB-independent uptake of proteins - - - 3.154e-204 665.0
HFD2_k127_2028025_9 Involved in the tonB-independent uptake of proteins - - - 1.36e-197 645.0
HFD2_k127_2139868_0 Heat shock 70 kDa protein K04043 - - 4.319e-301 935.0
HFD2_k127_2139868_1 Fumarate reductase flavoprotein C-term K00239,K00244 - 1.3.5.1,1.3.5.4 3.018e-248 781.0
HFD2_k127_2139868_10 5'-nucleotidase K01081,K01119,K11751 - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 430.0
HFD2_k127_2139868_11 Belongs to the PstS family K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 416.0
HFD2_k127_2139868_12 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 404.0
HFD2_k127_2139868_13 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 384.0
HFD2_k127_2139868_14 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 387.0
HFD2_k127_2139868_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 372.0
HFD2_k127_2139868_16 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 356.0
HFD2_k127_2139868_17 succinate dehydrogenase K00240 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 336.0
HFD2_k127_2139868_18 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 322.0
HFD2_k127_2139868_19 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 327.0
HFD2_k127_2139868_2 Carboxypeptidase regulatory-like domain - - - 2.676e-228 753.0
HFD2_k127_2139868_20 response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 323.0
HFD2_k127_2139868_21 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 329.0
HFD2_k127_2139868_22 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 306.0
HFD2_k127_2139868_23 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002157 274.0
HFD2_k127_2139868_24 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000002687 257.0
HFD2_k127_2139868_25 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000454 266.0
HFD2_k127_2139868_26 PFAM Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000001201 252.0
HFD2_k127_2139868_27 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001876 261.0
HFD2_k127_2139868_28 Phenylacetate-CoA oxygenase K15512 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000000000000003144 235.0
HFD2_k127_2139868_29 A G-specific K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000004271 232.0
HFD2_k127_2139868_3 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.524e-213 683.0
HFD2_k127_2139868_30 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000004786 248.0
HFD2_k127_2139868_31 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.0000000000000000000000000000000000000000000000000000000000001222 224.0
HFD2_k127_2139868_32 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000209 216.0
HFD2_k127_2139868_33 COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like K02428,K02499 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000001921 214.0
HFD2_k127_2139868_34 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.0000000000000000000000000000000000000000000000000000008452 199.0
HFD2_k127_2139868_35 Phosphate transport system permease protein PstA K02038 - - 0.0000000000000000000000000000000000000000000000000001819 192.0
HFD2_k127_2139868_36 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000006336 186.0
HFD2_k127_2139868_37 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000005371 198.0
HFD2_k127_2139868_38 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000005886 173.0
HFD2_k127_2139868_39 Divergent polysaccharide deacetylase K09798 - - 0.000000000000000000000000000000000000000000001591 177.0
HFD2_k127_2139868_4 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.423e-203 647.0
HFD2_k127_2139868_40 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000003211 169.0
HFD2_k127_2139868_41 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000009919 166.0
HFD2_k127_2139868_42 PFAM alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000001145 161.0
HFD2_k127_2139868_43 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000002543 161.0
HFD2_k127_2139868_44 Peptidase M23 - - - 0.000000000000000000000000000000002865 143.0
HFD2_k127_2139868_45 MerR HTH family regulatory protein K13640 - - 0.000000000000000000000000000000009958 132.0
HFD2_k127_2139868_46 Thioesterase superfamily K10806 - - 0.00000000000000000000000000000001826 131.0
HFD2_k127_2139868_47 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000003147 138.0
HFD2_k127_2139868_48 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000003467 143.0
HFD2_k127_2139868_49 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000004656 113.0
HFD2_k127_2139868_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 574.0
HFD2_k127_2139868_50 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000456 118.0
HFD2_k127_2139868_51 Phosphoglycerate mutase family K08296 - - 0.000000000000000000000003336 108.0
HFD2_k127_2139868_52 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000002264 103.0
HFD2_k127_2139868_53 oxidoreductase activity - - - 0.00000000000000000001856 106.0
HFD2_k127_2139868_54 Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000009088 94.0
HFD2_k127_2139868_55 Peptidase M56 - - - 0.0000000000000000438 95.0
HFD2_k127_2139868_56 - - - - 0.000000000000003774 88.0
HFD2_k127_2139868_57 Alg9-like mannosyltransferase family - - - 0.00000000005567 76.0
HFD2_k127_2139868_58 Peptidase M56 - - - 0.0000000003365 73.0
HFD2_k127_2139868_59 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000002207 71.0
HFD2_k127_2139868_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 499.0
HFD2_k127_2139868_61 zinc protease K07054 - - 0.000000003174 68.0
HFD2_k127_2139868_62 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000003891 67.0
HFD2_k127_2139868_63 CHAD - - - 0.00000005499 63.0
HFD2_k127_2139868_64 Domain of unknown function (DUF1844) - - - 0.0000001598 59.0
HFD2_k127_2139868_65 Domain of unknown function (DUF4388) - - - 0.0000004366 63.0
HFD2_k127_2139868_66 - - - - 0.000001993 60.0
HFD2_k127_2139868_67 Uncharacterised protein family (UPF0158) - - - 0.000004938 54.0
HFD2_k127_2139868_68 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000057 59.0
HFD2_k127_2139868_69 protein kinase activity - - - 0.000007875 59.0
HFD2_k127_2139868_7 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 485.0
HFD2_k127_2139868_70 phosphorelay signal transduction system - - - 0.0005479 52.0
HFD2_k127_2139868_8 Belongs to the DEAD box helicase family K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 464.0
HFD2_k127_2139868_9 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 427.0
HFD2_k127_2233526_0 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000001074 153.0
HFD2_k127_2233526_1 cellulose binding - - - 0.000000000000000000000000000000001901 151.0
HFD2_k127_2233526_2 PFAM ABC transporter K09691 - - 0.00000000000000006673 83.0
HFD2_k127_2233526_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000007368 67.0
HFD2_k127_2320847_0 Tetratricopeptide repeat K08309 - - 0.000000000009159 77.0
HFD2_k127_2320847_1 - K03646 - - 0.000000000009935 73.0
HFD2_k127_2401770_0 Involved in the tonB-independent uptake of proteins - - - 2.115e-202 664.0
HFD2_k127_2401770_1 Protein kinase domain K12132 - 2.7.11.1 5.466e-194 636.0
HFD2_k127_2401770_10 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000006004 213.0
HFD2_k127_2401770_11 Adenylate cyclase - - - 0.0000000000000000000009485 105.0
HFD2_k127_2401770_12 Adenylate cyclase - - - 0.0000000000007948 79.0
HFD2_k127_2401770_13 Peptidase M56 - - - 0.000000000005702 77.0
HFD2_k127_2401770_14 ATP-binding region ATPase domain protein - - - 0.00000007936 64.0
HFD2_k127_2401770_2 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 618.0
HFD2_k127_2401770_3 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 557.0
HFD2_k127_2401770_4 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 501.0
HFD2_k127_2401770_5 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 495.0
HFD2_k127_2401770_6 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 480.0
HFD2_k127_2401770_7 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004606 291.0
HFD2_k127_2401770_8 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000004178 220.0
HFD2_k127_2401770_9 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000006315 226.0
HFD2_k127_2442_0 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 410.0
HFD2_k127_2442_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 355.0
HFD2_k127_2442_10 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000009854 94.0
HFD2_k127_2442_11 domain protein - - - 0.0000000000000000002347 104.0
HFD2_k127_2442_12 DNA polymerase III (delta' subunit) K02340 - 2.7.7.7 0.0000000005107 72.0
HFD2_k127_2442_2 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000003734 222.0
HFD2_k127_2442_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000001043 196.0
HFD2_k127_2442_4 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000002909 196.0
HFD2_k127_2442_5 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000000003053 135.0
HFD2_k127_2442_6 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000006092 140.0
HFD2_k127_2442_7 metallopeptidase activity - - - 0.000000000000000000000000008912 113.0
HFD2_k127_2442_8 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000001085 114.0
HFD2_k127_2442_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000001953 108.0
HFD2_k127_2474631_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.7e-246 794.0
HFD2_k127_2474631_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.835e-243 762.0
HFD2_k127_2474631_10 ASPIC and UnbV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 496.0
HFD2_k127_2474631_11 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 468.0
HFD2_k127_2474631_12 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 460.0
HFD2_k127_2474631_13 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 453.0
HFD2_k127_2474631_14 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 442.0
HFD2_k127_2474631_15 COG0464 ATPases of the AAA class - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 424.0
HFD2_k127_2474631_16 7TM-HD extracellular K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 420.0
HFD2_k127_2474631_17 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 404.0
HFD2_k127_2474631_18 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 390.0
HFD2_k127_2474631_19 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 381.0
HFD2_k127_2474631_2 PFAM UvrD REP helicase K03657 - 3.6.4.12 5.555e-206 662.0
HFD2_k127_2474631_20 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 378.0
HFD2_k127_2474631_21 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 376.0
HFD2_k127_2474631_22 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 376.0
HFD2_k127_2474631_23 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 371.0
HFD2_k127_2474631_24 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 376.0
HFD2_k127_2474631_25 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 364.0
HFD2_k127_2474631_26 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 381.0
HFD2_k127_2474631_27 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 362.0
HFD2_k127_2474631_28 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 365.0
HFD2_k127_2474631_29 Male sterility protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009927 359.0
HFD2_k127_2474631_3 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 599.0
HFD2_k127_2474631_30 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 322.0
HFD2_k127_2474631_31 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 305.0
HFD2_k127_2474631_32 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 288.0
HFD2_k127_2474631_33 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006197 278.0
HFD2_k127_2474631_34 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000006848 271.0
HFD2_k127_2474631_35 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001874 261.0
HFD2_k127_2474631_36 PFAM Glycosyl transferase family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002045 263.0
HFD2_k127_2474631_37 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000226 272.0
HFD2_k127_2474631_38 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003966 261.0
HFD2_k127_2474631_39 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000003535 250.0
HFD2_k127_2474631_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 564.0
HFD2_k127_2474631_40 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000004512 235.0
HFD2_k127_2474631_41 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000506 258.0
HFD2_k127_2474631_42 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000003101 246.0
HFD2_k127_2474631_43 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000005702 235.0
HFD2_k127_2474631_44 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000001231 224.0
HFD2_k127_2474631_45 Hexapeptide repeat of succinyl-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000001526 223.0
HFD2_k127_2474631_46 sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000005831 235.0
HFD2_k127_2474631_47 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000002746 229.0
HFD2_k127_2474631_48 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000006787 217.0
HFD2_k127_2474631_49 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000001414 213.0
HFD2_k127_2474631_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 523.0
HFD2_k127_2474631_50 flavin adenine dinucleotide binding - - - 0.000000000000000000000000000000000000000000000000000000007378 219.0
HFD2_k127_2474631_51 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000002849 199.0
HFD2_k127_2474631_52 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000009497 194.0
HFD2_k127_2474631_53 Cupin domain - - - 0.0000000000000000000000000000000000000000000000002308 179.0
HFD2_k127_2474631_54 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000159 192.0
HFD2_k127_2474631_55 Subtilase family - - - 0.00000000000000000000000000000000000000000000002011 196.0
HFD2_k127_2474631_56 RelA SpoT domain protein - - - 0.00000000000000000000000000000000000000000000002973 196.0
HFD2_k127_2474631_57 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000002848 171.0
HFD2_k127_2474631_58 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000000004641 164.0
HFD2_k127_2474631_59 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000001326 173.0
HFD2_k127_2474631_6 DNA segregation ATPase, FtsK SpoIIIE family K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 531.0
HFD2_k127_2474631_60 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000285 160.0
HFD2_k127_2474631_61 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000002591 157.0
HFD2_k127_2474631_62 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000008131 144.0
HFD2_k127_2474631_63 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000000000000000000000000005823 139.0
HFD2_k127_2474631_64 MlaD protein K02067 - - 0.00000000000000000000000000000000001088 151.0
HFD2_k127_2474631_65 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.00000000000000000000000000004391 117.0
HFD2_k127_2474631_66 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000000000000001487 124.0
HFD2_k127_2474631_67 Pentapeptide repeats (9 copies) - - - 0.0000000000000000000000000001562 131.0
HFD2_k127_2474631_68 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000002713 112.0
HFD2_k127_2474631_69 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000001822 113.0
HFD2_k127_2474631_7 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004173 500.0
HFD2_k127_2474631_70 Domain of unknown function (DUF4340) - - - 0.000000000000000000006142 107.0
HFD2_k127_2474631_71 domain, Protein - - - 0.00000000000002052 85.0
HFD2_k127_2474631_72 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.0000000000004897 76.0
HFD2_k127_2474631_73 ECF sigma factor K03088 - - 0.000000000001269 78.0
HFD2_k127_2474631_74 Protein of unknown function, DUF255 - - - 0.000000000004137 74.0
HFD2_k127_2474631_75 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.0000000002624 66.0
HFD2_k127_2474631_76 Protein of unknown function (DUF1499) - - - 0.00000003955 58.0
HFD2_k127_2474631_77 O-Antigen ligase - - - 0.00000009419 65.0
HFD2_k127_2474631_78 O-antigen polymerase - - - 0.000004839 60.0
HFD2_k127_2474631_79 ATP-independent chaperone mediated protein folding K06006 - - 0.000135 51.0
HFD2_k127_2474631_8 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 513.0
HFD2_k127_2474631_80 oligosaccharyl transferase activity - - - 0.0003536 53.0
HFD2_k127_2474631_9 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 490.0
HFD2_k127_2635662_0 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 7.778e-210 667.0
HFD2_k127_2635662_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 584.0
HFD2_k127_2635662_10 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000007345 202.0
HFD2_k127_2635662_11 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000171 155.0
HFD2_k127_2635662_12 Thioesterase - - - 0.00000000000000000000000000000001412 130.0
HFD2_k127_2635662_13 - - - - 0.0000000000002303 75.0
HFD2_k127_2635662_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 502.0
HFD2_k127_2635662_3 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 473.0
HFD2_k127_2635662_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 401.0
HFD2_k127_2635662_5 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 401.0
HFD2_k127_2635662_6 Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004588 297.0
HFD2_k127_2635662_7 Alpha beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002359 271.0
HFD2_k127_2635662_8 phospho-2-dehydro-3-deoxyheptonate aldolase K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000006694 242.0
HFD2_k127_2635662_9 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000005642 226.0
HFD2_k127_2667221_0 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 291.0
HFD2_k127_2667221_1 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000002885 192.0
HFD2_k127_2667221_2 NHL repeat - - - 0.00000000000000000000000001023 123.0
HFD2_k127_2667221_3 FAD binding domain - - - 0.00000000000000000008103 91.0
HFD2_k127_2689906_0 Tfp pilus assembly protein, tip-associated adhesin PilY1 K02674 - - 0.0000000000000000000002891 114.0
HFD2_k127_2707943_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 8.002e-301 943.0
HFD2_k127_2707943_1 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 7.206e-275 859.0
HFD2_k127_2707943_10 abc transporter, ATP-binding protein K01995,K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006522 372.0
HFD2_k127_2707943_11 PFAM Major facilitator superfamily K08224 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 365.0
HFD2_k127_2707943_12 MFS/sugar transport protein K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 335.0
HFD2_k127_2707943_13 formate dehydrogenase K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 318.0
HFD2_k127_2707943_14 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001711 280.0
HFD2_k127_2707943_15 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005693 276.0
HFD2_k127_2707943_16 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000006207 262.0
HFD2_k127_2707943_17 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004521 259.0
HFD2_k127_2707943_18 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001489 264.0
HFD2_k127_2707943_19 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000168 256.0
HFD2_k127_2707943_2 Isocitrate lyase family K01637 - 4.1.3.1 2.718e-208 656.0
HFD2_k127_2707943_20 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000002973 243.0
HFD2_k127_2707943_21 L-phenylalanine transmembrane transporter activity K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000006807 246.0
HFD2_k127_2707943_22 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000002602 241.0
HFD2_k127_2707943_23 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000004638 246.0
HFD2_k127_2707943_24 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000231 218.0
HFD2_k127_2707943_25 4-oxalocrotonate tautomerase - - - 0.00000000000000000000000000000000000000000002619 164.0
HFD2_k127_2707943_26 formate dehydrogenase K00127,K08350 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.000000000000000000000000000000000000000007494 178.0
HFD2_k127_2707943_27 protein involved in formate dehydrogenase formation K02380 - - 0.0000000000000000000000000001568 126.0
HFD2_k127_2707943_28 mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.00005974 55.0
HFD2_k127_2707943_3 IrrE N-terminal-like domain K07110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 542.0
HFD2_k127_2707943_4 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 512.0
HFD2_k127_2707943_5 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 459.0
HFD2_k127_2707943_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 442.0
HFD2_k127_2707943_7 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 411.0
HFD2_k127_2707943_8 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 399.0
HFD2_k127_2707943_9 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 365.0
HFD2_k127_2763423_0 PLD-like domain K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 589.0
HFD2_k127_2763423_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 584.0
HFD2_k127_2763423_10 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.000000000000000000000000476 111.0
HFD2_k127_2763423_11 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000005069 117.0
HFD2_k127_2763423_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000617 101.0
HFD2_k127_2763423_13 Protein tyrosine kinase - - - 0.000000000000000000002481 97.0
HFD2_k127_2763423_14 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000001878 93.0
HFD2_k127_2763423_15 Cytochrome c K17223 - - 0.0000000000002986 79.0
HFD2_k127_2763423_16 protein secretion K03116 GO:0008150,GO:0040007 - 0.000000000003871 69.0
HFD2_k127_2763423_17 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000007512 55.0
HFD2_k127_2763423_2 PFAM oxidoreductase FAD NAD(P)-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 500.0
HFD2_k127_2763423_3 Cytochrome b(N-terminal)/b6/petB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 297.0
HFD2_k127_2763423_4 Metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007644 282.0
HFD2_k127_2763423_5 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000007567 252.0
HFD2_k127_2763423_6 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000002886 173.0
HFD2_k127_2763423_7 Polysaccharide lyase family 4, domain II - - - 0.00000000000000000000000000000000000000000000003498 175.0
HFD2_k127_2763423_8 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000004726 136.0
HFD2_k127_2763423_9 protein histidine kinase activity K06375 - - 0.00000000000000000000000000006744 124.0
HFD2_k127_2814750_0 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 567.0
HFD2_k127_2814750_1 TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 505.0
HFD2_k127_2814750_2 sensor diguanylate cyclase phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006935 472.0
HFD2_k127_2814750_3 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 363.0
HFD2_k127_2845406_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3068.0
HFD2_k127_2845406_1 B12 binding domain K00548 - 2.1.1.13 0.0 1335.0
HFD2_k127_2845406_10 Aminotransferase class-III K03918,K07250,K20428 - 2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 601.0
HFD2_k127_2845406_11 Dehydrogenase K00004,K00008 - 1.1.1.14,1.1.1.303,1.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 540.0
HFD2_k127_2845406_12 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 540.0
HFD2_k127_2845406_13 Aldo/keto reductase family K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 506.0
HFD2_k127_2845406_14 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 494.0
HFD2_k127_2845406_15 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008023 493.0
HFD2_k127_2845406_16 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 494.0
HFD2_k127_2845406_17 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 432.0
HFD2_k127_2845406_18 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 401.0
HFD2_k127_2845406_19 Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 373.0
HFD2_k127_2845406_2 cellulose binding - - - 9.661e-232 757.0
HFD2_k127_2845406_20 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 376.0
HFD2_k127_2845406_21 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 391.0
HFD2_k127_2845406_22 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 374.0
HFD2_k127_2845406_23 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K00945,K02945,K03527 - 1.17.7.4,2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 376.0
HFD2_k127_2845406_24 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 355.0
HFD2_k127_2845406_25 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 325.0
HFD2_k127_2845406_26 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 321.0
HFD2_k127_2845406_27 Iron ABC transporter substrate-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 318.0
HFD2_k127_2845406_28 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 320.0
HFD2_k127_2845406_29 Belongs to the ABC transporter superfamily K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 295.0
HFD2_k127_2845406_3 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.874e-226 708.0
HFD2_k127_2845406_30 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008249 302.0
HFD2_k127_2845406_31 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002004 285.0
HFD2_k127_2845406_32 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001831 277.0
HFD2_k127_2845406_33 Phosphoribosyl transferase domain K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004401 261.0
HFD2_k127_2845406_34 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000755 267.0
HFD2_k127_2845406_35 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005626 250.0
HFD2_k127_2845406_36 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000129 255.0
HFD2_k127_2845406_37 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001448 250.0
HFD2_k127_2845406_38 PFAM Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003663 239.0
HFD2_k127_2845406_39 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K03802,K05844 - 6.3.2.29,6.3.2.30 0.00000000000000000000000000000000000000000000000000000000000000008512 237.0
HFD2_k127_2845406_4 Domain of unknown function (DUF4070) - - - 8.592e-220 694.0
HFD2_k127_2845406_40 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000001213 231.0
HFD2_k127_2845406_41 Squalene/phytoene synthase K00801 - 2.5.1.21 0.000000000000000000000000000000000000000000000000000000000001089 229.0
HFD2_k127_2845406_42 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001154 218.0
HFD2_k127_2845406_43 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K05305,K16881 - 2.7.1.52,2.7.7.13,5.4.2.8 0.0000000000000000000000000000000000000000000000000002744 210.0
HFD2_k127_2845406_44 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01560,K07025,K20862 - 3.1.3.102,3.1.3.104,3.8.1.2 0.0000000000000000000000000000000000000000000000000008684 209.0
HFD2_k127_2845406_45 sequence-specific DNA binding K03719 - - 0.000000000000000000000000000000000000000000000000002032 186.0
HFD2_k127_2845406_46 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000284 180.0
HFD2_k127_2845406_47 Belongs to the metal hydrolase YfiT family - - - 0.00000000000000000000000000000000000000000000001014 181.0
HFD2_k127_2845406_48 Glycosyl hydrolase-like 10 - - - 0.000000000000000000000000000000000000000000001494 184.0
HFD2_k127_2845406_49 COGs COG2905 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000000000000000000000000000905 175.0
HFD2_k127_2845406_5 PFAM Prenyltransferase squalene oxidase K06045 - 4.2.1.129,5.4.99.17 1.145e-208 672.0
HFD2_k127_2845406_50 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor K10672,K10794 - 1.21.4.1,1.21.4.2 0.0000000000000000000000000000000000000000009308 163.0
HFD2_k127_2845406_51 LexA-binding, inner membrane-associated putative hydrolase K07038 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000002898 152.0
HFD2_k127_2845406_53 DinB family - - - 0.00000000000000000000000000000000006346 150.0
HFD2_k127_2845406_54 Protein of unknown function (DUF2721) - - - 0.000000000000000000000000000000001266 135.0
HFD2_k127_2845406_55 CAAX protease self-immunity - - - 0.000000000000000000000000000000001398 147.0
HFD2_k127_2845406_56 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000001749 138.0
HFD2_k127_2845406_57 EamA-like transporter family - - - 0.000000000000000000000002847 116.0
HFD2_k127_2845406_58 peptidase - - - 0.000000000000000000000014 111.0
HFD2_k127_2845406_59 - - - - 0.00000000000000000000001512 108.0
HFD2_k127_2845406_6 Peptidase m28 - - - 1.635e-208 670.0
HFD2_k127_2845406_61 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.000000000000000005776 99.0
HFD2_k127_2845406_62 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000006264 91.0
HFD2_k127_2845406_63 Outer membrane protein beta-barrel domain - - - 0.0000000000000319 87.0
HFD2_k127_2845406_64 - - - - 0.0000000000001351 73.0
HFD2_k127_2845406_65 Phosphorylase superfamily K01243 - 3.2.2.9 0.00000000001915 74.0
HFD2_k127_2845406_66 Kelch-like family member 35 K10461,K13959 GO:0000151,GO:0005575,GO:0005622,GO:0005623,GO:0031461,GO:0031463,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1990234 - 0.00000000006015 72.0
HFD2_k127_2845406_67 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000002894 71.0
HFD2_k127_2845406_68 - - - - 0.000000002665 61.0
HFD2_k127_2845406_69 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000002825 59.0
HFD2_k127_2845406_7 PFAM peptidase M28 - - - 2.701e-202 646.0
HFD2_k127_2845406_70 Family of unknown function (DUF5335) - - - 0.000005756 55.0
HFD2_k127_2845406_71 PFAM Outer membrane efflux protein - - - 0.0002051 53.0
HFD2_k127_2845406_8 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 621.0
HFD2_k127_2845406_9 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 610.0
HFD2_k127_2858021_0 Hep Hag repeat protein - GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000001289 254.0
HFD2_k127_2858021_1 polysaccharide deacetylase - - - 0.00000000000003588 86.0
HFD2_k127_2858021_2 Protein of unknown function (DUF805) - - - 0.0002967 48.0
HFD2_k127_2970476_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 536.0
HFD2_k127_2970476_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 501.0
HFD2_k127_2970476_2 NAD dependent epimerase/dehydratase family K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 446.0
HFD2_k127_2970476_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 403.0
HFD2_k127_2970476_4 polysaccharide deacetylase K15531 - 3.2.1.156 0.000000000000002068 91.0
HFD2_k127_3242817_0 Amylo-alpha-1,6-glucosidase - - - 4.599e-244 771.0
HFD2_k127_3242817_1 choline dehydrogenase activity - - - 7.62e-210 659.0
HFD2_k127_3242817_2 GvpD gas vesicle protein K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 541.0
HFD2_k127_3242817_3 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 288.0
HFD2_k127_3242817_4 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000001594 248.0
HFD2_k127_3242817_5 Putative zinc-finger - - - 0.0000006938 56.0
HFD2_k127_3313735_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.184e-229 737.0
HFD2_k127_3313735_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 572.0
HFD2_k127_3313735_11 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009826 267.0
HFD2_k127_3313735_12 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000002062 255.0
HFD2_k127_3313735_13 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000006402 258.0
HFD2_k127_3313735_14 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009347 249.0
HFD2_k127_3313735_15 Deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000001386 252.0
HFD2_k127_3313735_16 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000005367 245.0
HFD2_k127_3313735_17 Proteasome subunit K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000001992 227.0
HFD2_k127_3313735_18 heme binding K21472 - - 0.000000000000000000000000000000000000000000000000000000003395 208.0
HFD2_k127_3313735_19 receptor K16092 - - 0.000000000000000000000000000000000000000000000000000000004281 223.0
HFD2_k127_3313735_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 484.0
HFD2_k127_3313735_20 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000000000000001241 208.0
HFD2_k127_3313735_21 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000003337 202.0
HFD2_k127_3313735_22 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000001249 201.0
HFD2_k127_3313735_23 Copper binding periplasmic protein CusF K07152 - - 0.000000000000000000000000000000000000000000000000006955 192.0
HFD2_k127_3313735_24 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000013 186.0
HFD2_k127_3313735_25 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000004927 183.0
HFD2_k127_3313735_26 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000008691 170.0
HFD2_k127_3313735_27 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000178 156.0
HFD2_k127_3313735_28 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0005488,GO:0005515,GO:0042802 4.3.3.6 0.000000000000000000000000000000000000001247 149.0
HFD2_k127_3313735_29 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000005393 151.0
HFD2_k127_3313735_3 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 482.0
HFD2_k127_3313735_30 Radical SAM superfamily - - - 0.0000000000000000000000000000000007456 147.0
HFD2_k127_3313735_31 high-affinity ferrous iron transmembrane transporter activity K07243 - - 0.000000000000000000000000000171 134.0
HFD2_k127_3313735_32 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000001285 126.0
HFD2_k127_3313735_33 Sortase family K07284 - 3.4.22.70 0.000000000000000000000000001373 119.0
HFD2_k127_3313735_35 Fibronectin type III domain protein - - - 0.00000000000000000007961 102.0
HFD2_k127_3313735_38 Glycosyl transferase family 2 - - - 0.0000000000000002314 91.0
HFD2_k127_3313735_39 ubiE/COQ5 methyltransferase family - - - 0.00000000000001047 83.0
HFD2_k127_3313735_4 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 435.0
HFD2_k127_3313735_40 Protein of unknown function (DUF1573) - - - 0.00000000000003569 85.0
HFD2_k127_3313735_43 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000001115 56.0
HFD2_k127_3313735_44 Belongs to the arylamine N-acetyltransferase family K00622 - 2.3.1.5 0.0001026 55.0
HFD2_k127_3313735_45 Protein of unknown function (DUF3052) - - - 0.0001796 50.0
HFD2_k127_3313735_5 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 456.0
HFD2_k127_3313735_6 Belongs to the MurCDEF family K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 402.0
HFD2_k127_3313735_7 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 376.0
HFD2_k127_3313735_8 - K12065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 372.0
HFD2_k127_3313735_9 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 355.0
HFD2_k127_3313764_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K03520,K11177 - 1.17.1.4,1.2.5.3 0.0 1318.0
HFD2_k127_3313764_1 COG NOG10142 non supervised orthologous group - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 534.0
HFD2_k127_3313764_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000001725 90.0
HFD2_k127_3313764_11 phosphorelay signal transduction system K14987 - - 0.0000000000002487 80.0
HFD2_k127_3313764_2 Associated with various cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 356.0
HFD2_k127_3313764_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 336.0
HFD2_k127_3313764_4 Aspartate ammonia-lyase K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 306.0
HFD2_k127_3313764_5 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000001004 252.0
HFD2_k127_3313764_6 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000483 248.0
HFD2_k127_3313764_7 metallochaperone-like domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000001563 230.0
HFD2_k127_3313764_8 surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000005831 231.0
HFD2_k127_3313764_9 oxidoreductase activity, acting on CH-OH group of donors K09386 - - 0.000000000000000000000000000000000001808 143.0
HFD2_k127_3506243_0 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 617.0
HFD2_k127_3506243_1 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 562.0
HFD2_k127_3506243_10 - - - - 0.0000002981 59.0
HFD2_k127_3506243_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007951 376.0
HFD2_k127_3506243_3 PFAM oxidoreductase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000003587 242.0
HFD2_k127_3506243_4 Represses a number of genes involved in the response to DNA damage (SOS response) K01356,K03503 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000005976 205.0
HFD2_k127_3506243_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000001653 174.0
HFD2_k127_3506243_6 - - - - 0.00000000000000000000000000005196 124.0
HFD2_k127_3506243_7 Conserved repeat domain - - - 0.0000000000000001033 94.0
HFD2_k127_3506243_8 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.000000000000003982 88.0
HFD2_k127_3507777_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005062 445.0
HFD2_k127_3507777_1 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 368.0
HFD2_k127_3507777_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.0000000000000000000000000002157 122.0
HFD2_k127_3507777_11 TIGRFAM redox-active disulfide protein 2 - - - 0.000000000000000003679 86.0
HFD2_k127_3507777_12 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000786 83.0
HFD2_k127_3507777_13 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741,K03892 - 1.20.4.1 0.00000000000000008396 91.0
HFD2_k127_3507777_2 Transcriptional regulator with HTH domain and aminotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 375.0
HFD2_k127_3507777_3 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 336.0
HFD2_k127_3507777_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009452 329.0
HFD2_k127_3507777_5 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008876 290.0
HFD2_k127_3507777_6 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001026 263.0
HFD2_k127_3507777_7 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008545 265.0
HFD2_k127_3507777_8 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000846 254.0
HFD2_k127_3507777_9 YbaK prolyl-tRNA synthetase associated region - - - 0.00000000000000000000000000000000000002739 157.0
HFD2_k127_3543104_0 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 626.0
HFD2_k127_3543104_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 499.0
HFD2_k127_3543104_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 286.0
HFD2_k127_3543104_3 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000001551 279.0
HFD2_k127_3543104_4 PRC-barrel domain - - - 0.000000000000000000000000000000000000000000006665 169.0
HFD2_k127_3543104_5 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000002797 166.0
HFD2_k127_3543104_7 hyperosmotic response - - - 0.0000000000000000000000009512 111.0
HFD2_k127_3543104_8 efflux transmembrane transporter activity - - - 0.0009153 44.0
HFD2_k127_3612954_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000001486 110.0
HFD2_k127_3612954_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.0000000001505 72.0
HFD2_k127_3621205_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.31e-276 872.0
HFD2_k127_3621205_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 6.412e-269 837.0
HFD2_k127_3621205_10 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 382.0
HFD2_k127_3621205_11 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 338.0
HFD2_k127_3621205_12 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 361.0
HFD2_k127_3621205_13 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 331.0
HFD2_k127_3621205_14 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 327.0
HFD2_k127_3621205_15 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 312.0
HFD2_k127_3621205_16 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 292.0
HFD2_k127_3621205_17 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 290.0
HFD2_k127_3621205_18 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 290.0
HFD2_k127_3621205_19 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 295.0
HFD2_k127_3621205_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.544e-228 732.0
HFD2_k127_3621205_20 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003929 282.0
HFD2_k127_3621205_21 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003602 278.0
HFD2_k127_3621205_22 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005631 269.0
HFD2_k127_3621205_23 SMART protein phosphatase 2C domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001462 271.0
HFD2_k127_3621205_24 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003525 276.0
HFD2_k127_3621205_25 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000003638 246.0
HFD2_k127_3621205_26 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000006181 242.0
HFD2_k127_3621205_27 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000007278 225.0
HFD2_k127_3621205_28 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000007434 226.0
HFD2_k127_3621205_29 cytochrome c nitrite reductase K15876 - - 0.00000000000000000000000000000000000000000000000000000000000007873 216.0
HFD2_k127_3621205_3 Peptidase M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 643.0
HFD2_k127_3621205_30 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000001195 227.0
HFD2_k127_3621205_31 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000000000000000000001663 216.0
HFD2_k127_3621205_32 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000003244 216.0
HFD2_k127_3621205_33 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000008763 213.0
HFD2_k127_3621205_34 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000003901 200.0
HFD2_k127_3621205_35 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000009962 198.0
HFD2_k127_3621205_36 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000003735 201.0
HFD2_k127_3621205_37 - - - - 0.00000000000000000000000000000000000000000000000001083 192.0
HFD2_k127_3621205_38 Transmembrane and - - - 0.00000000000000000000000000000000000000000000001498 194.0
HFD2_k127_3621205_39 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000005771 177.0
HFD2_k127_3621205_4 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008229 546.0
HFD2_k127_3621205_40 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000002563 154.0
HFD2_k127_3621205_41 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.0000000000000000000000000000002389 137.0
HFD2_k127_3621205_42 PFAM response regulator receiver - - - 0.000000000000000000000000000004285 131.0
HFD2_k127_3621205_43 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000003717 130.0
HFD2_k127_3621205_44 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000005539 114.0
HFD2_k127_3621205_45 Protein of unknown function DUF58 - - - 0.000000000000000000000000002673 124.0
HFD2_k127_3621205_46 Transglutaminase/protease-like homologues - - - 0.000000000000000000000001032 121.0
HFD2_k127_3621205_47 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000006756 106.0
HFD2_k127_3621205_48 PFAM Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.00000000000000000000007357 106.0
HFD2_k127_3621205_49 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000001058 98.0
HFD2_k127_3621205_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 514.0
HFD2_k127_3621205_50 PFAM conserved K07027 - - 0.000000000000000000003987 106.0
HFD2_k127_3621205_51 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000007435 100.0
HFD2_k127_3621205_52 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.00000000000000000005566 104.0
HFD2_k127_3621205_53 Salt-Induced Outer Membrane Protein K07283 - - 0.000000000000000003987 94.0
HFD2_k127_3621205_54 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000007895 95.0
HFD2_k127_3621205_55 Sulfurtransferase TusA K04085 - - 0.000000000000000008798 87.0
HFD2_k127_3621205_56 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000124 90.0
HFD2_k127_3621205_57 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000001344 97.0
HFD2_k127_3621205_58 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.00000000000000003243 87.0
HFD2_k127_3621205_59 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000001104 77.0
HFD2_k127_3621205_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 479.0
HFD2_k127_3621205_60 SNARE associated Golgi protein - - - 0.0000000004574 61.0
HFD2_k127_3621205_62 Protein of unknown function (DUF3313) - - - 0.0000005593 55.0
HFD2_k127_3621205_64 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain K05989 - 3.2.1.40 0.000741 49.0
HFD2_k127_3621205_65 Tetratricopeptide repeat - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0006605,GO:0006626,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0008104,GO:0008150,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070585,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0072594,GO:0072655 - 0.0008665 48.0
HFD2_k127_3621205_7 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 479.0
HFD2_k127_3621205_8 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 441.0
HFD2_k127_3621205_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006855 385.0
HFD2_k127_3633764_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 5.028e-266 856.0
HFD2_k127_3633764_1 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 566.0
HFD2_k127_3633764_10 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 412.0
HFD2_k127_3633764_11 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007615 409.0
HFD2_k127_3633764_12 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 389.0
HFD2_k127_3633764_13 Proton-conducting membrane transporter K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 381.0
HFD2_k127_3633764_14 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 388.0
HFD2_k127_3633764_15 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008138 337.0
HFD2_k127_3633764_16 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009651 325.0
HFD2_k127_3633764_17 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 323.0
HFD2_k127_3633764_18 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 293.0
HFD2_k127_3633764_19 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002978 286.0
HFD2_k127_3633764_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 541.0
HFD2_k127_3633764_20 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001507 287.0
HFD2_k127_3633764_21 Peptidase M14, carboxypeptidase A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005333 282.0
HFD2_k127_3633764_22 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000002496 282.0
HFD2_k127_3633764_23 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000158 247.0
HFD2_k127_3633764_24 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000008688 259.0
HFD2_k127_3633764_25 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000002152 228.0
HFD2_k127_3633764_26 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000001667 211.0
HFD2_k127_3633764_27 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000003667 215.0
HFD2_k127_3633764_28 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000001242 168.0
HFD2_k127_3633764_29 Hydrogenase 4 membrane - - - 0.00000000000000000000000000000000000000002989 167.0
HFD2_k127_3633764_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 507.0
HFD2_k127_3633764_30 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000008595 152.0
HFD2_k127_3633764_31 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000009961 159.0
HFD2_k127_3633764_32 PPIC-type PPIASE domain K03769,K07533 - 5.2.1.8 0.0000000000000001087 94.0
HFD2_k127_3633764_33 calcium- and calmodulin-responsive adenylate cyclase activity K01406 - 3.4.24.40 0.000000000000007296 85.0
HFD2_k127_3633764_34 Essential cell division protein K03589 - - 0.00000000000002205 83.0
HFD2_k127_3633764_35 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.0000000007386 68.0
HFD2_k127_3633764_36 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0000004161 60.0
HFD2_k127_3633764_37 Protein of unknown function (DUF454) K09790 - - 0.0005502 47.0
HFD2_k127_3633764_4 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 504.0
HFD2_k127_3633764_5 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 504.0
HFD2_k127_3633764_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 445.0
HFD2_k127_3633764_7 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 438.0
HFD2_k127_3633764_8 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 433.0
HFD2_k127_3633764_9 PASTA domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 432.0
HFD2_k127_3677321_0 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 610.0
HFD2_k127_3677321_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 421.0
HFD2_k127_3677321_10 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 305.0
HFD2_k127_3677321_11 Domain of unknown function (DUF4162) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 294.0
HFD2_k127_3677321_12 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004574 278.0
HFD2_k127_3677321_13 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005922 276.0
HFD2_k127_3677321_14 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000117 273.0
HFD2_k127_3677321_15 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001304 276.0
HFD2_k127_3677321_16 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000004082 271.0
HFD2_k127_3677321_17 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000164 248.0
HFD2_k127_3677321_18 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000002223 239.0
HFD2_k127_3677321_19 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002055 250.0
HFD2_k127_3677321_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 403.0
HFD2_k127_3677321_20 GAF domain K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000000000000000006884 216.0
HFD2_k127_3677321_21 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000002648 212.0
HFD2_k127_3677321_22 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000648 219.0
HFD2_k127_3677321_23 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000000000000000000000008473 205.0
HFD2_k127_3677321_24 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000001341 211.0
HFD2_k127_3677321_25 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000296 173.0
HFD2_k127_3677321_26 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000002922 139.0
HFD2_k127_3677321_27 SMART Metal-dependent phosphohydrolase, HD region K07141 - 2.7.7.76 0.000000000000000000000000000007377 132.0
HFD2_k127_3677321_28 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000107 136.0
HFD2_k127_3677321_29 Protein of unknown function (DUF971) K03593 - - 0.000000000000000000000000049 110.0
HFD2_k127_3677321_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 371.0
HFD2_k127_3677321_30 Sodium:solute symporter family K03307 - - 0.0000000000000000000000001882 121.0
HFD2_k127_3677321_31 - - - - 0.0000000000000000000000009219 115.0
HFD2_k127_3677321_32 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000003225 100.0
HFD2_k127_3677321_33 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000001933 98.0
HFD2_k127_3677321_34 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000001879 100.0
HFD2_k127_3677321_35 Transcriptional regulator - - - 0.0000000000000001782 86.0
HFD2_k127_3677321_36 ECF sigma factor - - - 0.0000000003429 65.0
HFD2_k127_3677321_37 - - - - 0.0000004761 55.0
HFD2_k127_3677321_38 Domain of unknown function (DUF4149) - - - 0.000001882 59.0
HFD2_k127_3677321_39 Putative zinc-finger - - - 0.000003416 57.0
HFD2_k127_3677321_4 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 338.0
HFD2_k127_3677321_41 - - - - 0.0003267 46.0
HFD2_k127_3677321_5 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 360.0
HFD2_k127_3677321_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 340.0
HFD2_k127_3677321_7 Peptidase dimerisation domain K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 320.0
HFD2_k127_3677321_8 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 317.0
HFD2_k127_3677321_9 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 298.0
HFD2_k127_3728112_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0 1785.0
HFD2_k127_3728112_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 5.26e-279 886.0
HFD2_k127_3728112_10 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000004027 220.0
HFD2_k127_3728112_11 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000001621 243.0
HFD2_k127_3728112_12 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000002185 211.0
HFD2_k127_3728112_13 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000001231 221.0
HFD2_k127_3728112_14 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000643 213.0
HFD2_k127_3728112_15 Belongs to the HAM1 NTPase family K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000145 165.0
HFD2_k127_3728112_16 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000003953 143.0
HFD2_k127_3728112_17 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000001845 149.0
HFD2_k127_3728112_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000003201 121.0
HFD2_k127_3728112_19 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000003513 98.0
HFD2_k127_3728112_2 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 6.179e-247 780.0
HFD2_k127_3728112_20 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 0.0000000000000004714 91.0
HFD2_k127_3728112_21 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000005082 76.0
HFD2_k127_3728112_22 outer membrane autotransporter barrel domain protein - - - 0.0000000000003761 78.0
HFD2_k127_3728112_23 Glutaredoxin-like domain (DUF836) - - - 0.00000000002262 74.0
HFD2_k127_3728112_24 energy transducer activity K03832 - - 0.0003116 44.0
HFD2_k127_3728112_3 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 619.0
HFD2_k127_3728112_4 CoA carboxylase activity K01968 - 6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 490.0
HFD2_k127_3728112_5 Aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 395.0
HFD2_k127_3728112_6 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 358.0
HFD2_k127_3728112_7 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 347.0
HFD2_k127_3728112_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000001039 284.0
HFD2_k127_3728112_9 PFAM Enoyl-CoA hydratase isomerase K13766,K15312 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000009782 267.0
HFD2_k127_3763207_0 Carbamoyltransferase C-terminus K00612 - - 7e-323 996.0
HFD2_k127_3763207_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.926e-277 871.0
HFD2_k127_3763207_10 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 442.0
HFD2_k127_3763207_11 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 413.0
HFD2_k127_3763207_12 PFAM Glycosyl transferase family 2 K10012,K20534 - 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 386.0
HFD2_k127_3763207_13 Arginosuccinate synthase K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 382.0
HFD2_k127_3763207_14 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 370.0
HFD2_k127_3763207_15 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 363.0
HFD2_k127_3763207_16 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 337.0
HFD2_k127_3763207_17 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 335.0
HFD2_k127_3763207_18 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 308.0
HFD2_k127_3763207_19 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008362 312.0
HFD2_k127_3763207_2 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.364e-264 825.0
HFD2_k127_3763207_20 NHL repeat K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 312.0
HFD2_k127_3763207_21 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 298.0
HFD2_k127_3763207_22 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001371 283.0
HFD2_k127_3763207_23 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003294 284.0
HFD2_k127_3763207_24 Mo-molybdopterin cofactor biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002888 286.0
HFD2_k127_3763207_25 Glycosyltransferase group 2 family protein K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004443 274.0
HFD2_k127_3763207_26 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004286 265.0
HFD2_k127_3763207_27 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000373 279.0
HFD2_k127_3763207_28 Uncharacterized membrane protein (DUF2298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006611 269.0
HFD2_k127_3763207_29 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000001325 248.0
HFD2_k127_3763207_3 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 7.021e-206 663.0
HFD2_k127_3763207_30 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000587 246.0
HFD2_k127_3763207_31 Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000001038 256.0
HFD2_k127_3763207_32 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000002444 241.0
HFD2_k127_3763207_33 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000002903 243.0
HFD2_k127_3763207_34 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000263 237.0
HFD2_k127_3763207_35 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000003066 232.0
HFD2_k127_3763207_36 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000006048 227.0
HFD2_k127_3763207_37 Thioredoxin K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000004767 202.0
HFD2_k127_3763207_38 Exopolysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000002346 213.0
HFD2_k127_3763207_39 protein phosphatase 2C domain protein K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000006832 189.0
HFD2_k127_3763207_4 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K02805 GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016769,GO:0019180,GO:0019842,GO:0030170,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901576 2.6.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 547.0
HFD2_k127_3763207_40 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000002861 188.0
HFD2_k127_3763207_41 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000004067 182.0
HFD2_k127_3763207_42 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000002565 196.0
HFD2_k127_3763207_43 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000003297 188.0
HFD2_k127_3763207_44 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000003291 171.0
HFD2_k127_3763207_45 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000002248 167.0
HFD2_k127_3763207_46 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000001908 180.0
HFD2_k127_3763207_47 - - - - 0.000000000000000000000000000000000000004619 167.0
HFD2_k127_3763207_48 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000001087 154.0
HFD2_k127_3763207_49 NHL repeat - - - 0.00000000000000000000000000000000000001281 168.0
HFD2_k127_3763207_5 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 556.0
HFD2_k127_3763207_50 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000001071 151.0
HFD2_k127_3763207_51 Glycosyltransferase like family 2 K10012 - 2.4.2.53 0.000000000000000000000000000000007299 137.0
HFD2_k127_3763207_52 acetyltransferase - - - 0.00000000000000000000000000000001274 142.0
HFD2_k127_3763207_53 NHL repeat - - - 0.000000000000000000000000000000111 145.0
HFD2_k127_3763207_54 Uncharacterised protein family UPF0066 K01628 - 4.1.2.17 0.000000000000000000000000000000291 139.0
HFD2_k127_3763207_55 Methyltransferase domain - - - 0.0000000000000000000000195 113.0
HFD2_k127_3763207_56 AraC-like ligand binding domain - - - 0.0000000000000000000001158 99.0
HFD2_k127_3763207_57 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000002122 114.0
HFD2_k127_3763207_58 - - - - 0.00000000000000000002472 105.0
HFD2_k127_3763207_59 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000002596 106.0
HFD2_k127_3763207_6 Permease family K06901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 529.0
HFD2_k127_3763207_60 GYD domain - - - 0.0000000000000000002071 94.0
HFD2_k127_3763207_61 beta-galactosidase activity - - - 0.000000000000000001211 93.0
HFD2_k127_3763207_62 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.00000000000000001718 91.0
HFD2_k127_3763207_63 - - - - 0.00000000000001408 74.0
HFD2_k127_3763207_67 lipolytic protein G-D-S-L family - - - 0.0000000008186 71.0
HFD2_k127_3763207_68 Uncharacterised protein family UPF0066 - - - 0.000000005175 60.0
HFD2_k127_3763207_69 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000004185 61.0
HFD2_k127_3763207_7 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 509.0
HFD2_k127_3763207_70 COGs COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family - - - 0.000004775 60.0
HFD2_k127_3763207_71 Involved in the tonB-independent uptake of proteins - - - 0.00004872 46.0
HFD2_k127_3763207_72 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0001071 56.0
HFD2_k127_3763207_73 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0001212 55.0
HFD2_k127_3763207_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 469.0
HFD2_k127_3763207_9 Adenosine/AMP deaminase K01488,K21053 - 3.5.4.2,3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 433.0
HFD2_k127_3819143_0 ABC transporter K06020 - 3.6.3.25 3.48e-249 823.0
HFD2_k127_3819143_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 5.82e-247 765.0
HFD2_k127_3819143_10 Belongs to the UPF0403 family - - - 0.0000000000000000000000000000000000000007008 159.0
HFD2_k127_3819143_11 Protein of unknown function (DUF983) - - - 0.000000000000003413 82.0
HFD2_k127_3819143_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 6.865e-230 732.0
HFD2_k127_3819143_3 Saccharopine dehydrogenase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 332.0
HFD2_k127_3819143_4 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006873 329.0
HFD2_k127_3819143_5 Pyrroloquinoline quinone biosynthesis protein PqqB K06136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006726 273.0
HFD2_k127_3819143_6 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000001715 274.0
HFD2_k127_3819143_7 enzyme related to lactoylglutathione lyase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009958 254.0
HFD2_k127_3819143_8 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000002687 238.0
HFD2_k127_3819143_9 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000001347 202.0
HFD2_k127_3850979_0 MFP subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 460.0
HFD2_k127_3850979_1 Spermine/spermidine synthase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 434.0
HFD2_k127_3850979_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 451.0
HFD2_k127_3850979_3 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 368.0
HFD2_k127_3850979_4 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 314.0
HFD2_k127_3850979_5 Penicillinase repressor - - - 0.000000000000000000000000000000000000000003896 158.0
HFD2_k127_3850979_6 Peptidase M56 - - - 0.0000000000000000000000000000000000000001703 172.0
HFD2_k127_3850979_7 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000004707 135.0
HFD2_k127_3850979_8 efflux transmembrane transporter activity - - - 0.000000000000000002865 89.0
HFD2_k127_3871148_0 AMP-binding enzyme K01897 - 6.2.1.3 3.089e-288 907.0
HFD2_k127_3871148_1 amino acid K01999 - - 4.531e-197 625.0
HFD2_k127_3871148_10 amino acid transport system, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 406.0
HFD2_k127_3871148_11 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 426.0
HFD2_k127_3871148_12 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004981 381.0
HFD2_k127_3871148_13 transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 336.0
HFD2_k127_3871148_14 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 317.0
HFD2_k127_3871148_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009382 332.0
HFD2_k127_3871148_16 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 303.0
HFD2_k127_3871148_17 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007293 257.0
HFD2_k127_3871148_18 transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000004547 226.0
HFD2_k127_3871148_19 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000002828 216.0
HFD2_k127_3871148_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 506.0
HFD2_k127_3871148_20 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000007423 216.0
HFD2_k127_3871148_21 ABC transporter permease K01992 - - 0.000000000000000000000000000000000000000000000000008477 191.0
HFD2_k127_3871148_22 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000001988 175.0
HFD2_k127_3871148_23 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000001019 146.0
HFD2_k127_3871148_24 Hit family K02503 - - 0.0000000000000000000000000000000000197 138.0
HFD2_k127_3871148_25 helix_turn_helix ASNC type K03719 - - 0.000000000000000000000000000002564 127.0
HFD2_k127_3871148_26 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000000008355 115.0
HFD2_k127_3871148_27 Phosphoribosyl transferase domain - - - 0.00000000000000000000000001703 121.0
HFD2_k127_3871148_28 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000001851 100.0
HFD2_k127_3871148_29 Cupin domain - - - 0.0000003198 57.0
HFD2_k127_3871148_3 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 527.0
HFD2_k127_3871148_30 NB-ARC domain protein - - - 0.00002717 56.0
HFD2_k127_3871148_31 PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.0008382 51.0
HFD2_k127_3871148_4 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 495.0
HFD2_k127_3871148_5 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 477.0
HFD2_k127_3871148_6 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 479.0
HFD2_k127_3871148_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006748 427.0
HFD2_k127_3871148_8 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 421.0
HFD2_k127_3871148_9 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 407.0
HFD2_k127_3878444_0 helicase activity - - - 1.794e-316 987.0
HFD2_k127_3878444_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.332e-288 909.0
HFD2_k127_3878444_10 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 359.0
HFD2_k127_3878444_11 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 348.0
HFD2_k127_3878444_12 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 336.0
HFD2_k127_3878444_13 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 326.0
HFD2_k127_3878444_14 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 307.0
HFD2_k127_3878444_15 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 302.0
HFD2_k127_3878444_16 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008184 301.0
HFD2_k127_3878444_17 Cadherin repeats. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000221 313.0
HFD2_k127_3878444_18 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001891 290.0
HFD2_k127_3878444_19 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005035 284.0
HFD2_k127_3878444_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 4.07e-271 859.0
HFD2_k127_3878444_20 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003649 278.0
HFD2_k127_3878444_21 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004001 265.0
HFD2_k127_3878444_22 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000001267 245.0
HFD2_k127_3878444_23 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000005234 238.0
HFD2_k127_3878444_24 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000002279 233.0
HFD2_k127_3878444_25 Alanine-glyoxylate amino-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000004732 232.0
HFD2_k127_3878444_26 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000125 208.0
HFD2_k127_3878444_27 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.0000000000000000000000000000000000000000000000000004306 191.0
HFD2_k127_3878444_28 DinB family - - - 0.0000000000000000000000000000000000000000000001319 172.0
HFD2_k127_3878444_29 Histidine kinase - - - 0.000000000000000000000000000000000000000000007081 185.0
HFD2_k127_3878444_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.06e-234 732.0
HFD2_k127_3878444_30 TonB-dependent receptor K02014,K16087 - - 0.00000000000000000000000000000007881 145.0
HFD2_k127_3878444_31 thyroxine 5'-deiodinase activity K01562 GO:0003674,GO:0003824,GO:0004800,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006575,GO:0006590,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008430,GO:0009987,GO:0010817,GO:0016020,GO:0016491,GO:0018958,GO:0042403,GO:0042445,GO:0044237,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901360,GO:1901564,GO:1901615 1.21.99.4 0.0000000000000000000000000005669 117.0
HFD2_k127_3878444_32 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000004714 124.0
HFD2_k127_3878444_33 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000000000000003461 113.0
HFD2_k127_3878444_34 Tetratricopeptide repeat - - - 0.000000000000000000000005814 111.0
HFD2_k127_3878444_35 Polymer-forming cytoskeletal - - - 0.00000000000000000000000762 115.0
HFD2_k127_3878444_36 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000009296 100.0
HFD2_k127_3878444_37 Putative single-stranded nucleic acids-binding domain K06346 - - 0.000000000000000000001231 110.0
HFD2_k127_3878444_38 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000002871 95.0
HFD2_k127_3878444_39 - - - - 0.0000000000000000001734 96.0
HFD2_k127_3878444_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.654e-231 727.0
HFD2_k127_3878444_40 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000001251 71.0
HFD2_k127_3878444_41 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000001716 77.0
HFD2_k127_3878444_42 Peptidase, S41 - - - 0.00000007239 62.0
HFD2_k127_3878444_43 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000007876 57.0
HFD2_k127_3878444_44 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00001029 55.0
HFD2_k127_3878444_5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 605.0
HFD2_k127_3878444_6 metal ion transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 532.0
HFD2_k127_3878444_7 Winged helix DNA-binding domain K09927 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009236 526.0
HFD2_k127_3878444_8 D-aminoacylase domain protein K01465,K06015 - 3.5.1.81,3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 532.0
HFD2_k127_3878444_9 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 447.0
HFD2_k127_400881_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1495.0
HFD2_k127_400881_1 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1149.0
HFD2_k127_400881_10 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 599.0
HFD2_k127_400881_11 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 574.0
HFD2_k127_400881_12 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 559.0
HFD2_k127_400881_13 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 534.0
HFD2_k127_400881_14 Carbon-nitrogen hydrolase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 520.0
HFD2_k127_400881_15 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 505.0
HFD2_k127_400881_16 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 496.0
HFD2_k127_400881_17 serine threonine protein kinase K00870,K12132 - 2.7.1.37,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 469.0
HFD2_k127_400881_18 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 438.0
HFD2_k127_400881_19 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007244 424.0
HFD2_k127_400881_2 xanthine dehydrogenase activity - - - 2.845e-314 999.0
HFD2_k127_400881_20 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 418.0
HFD2_k127_400881_21 glycosyl transferase group 1 K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 423.0
HFD2_k127_400881_22 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 411.0
HFD2_k127_400881_23 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 413.0
HFD2_k127_400881_24 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 404.0
HFD2_k127_400881_25 allantoinase K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 397.0
HFD2_k127_400881_26 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 420.0
HFD2_k127_400881_27 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 400.0
HFD2_k127_400881_28 Ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 390.0
HFD2_k127_400881_29 Fructose-bisphosphate aldolase class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 379.0
HFD2_k127_400881_3 Sodium:solute symporter family - - - 9.91e-290 898.0
HFD2_k127_400881_30 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000997 374.0
HFD2_k127_400881_31 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009169 385.0
HFD2_k127_400881_32 Cardiolipin synthetase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 360.0
HFD2_k127_400881_33 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006288 347.0
HFD2_k127_400881_34 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 346.0
HFD2_k127_400881_35 Asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 338.0
HFD2_k127_400881_36 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 335.0
HFD2_k127_400881_37 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 329.0
HFD2_k127_400881_38 Phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 327.0
HFD2_k127_400881_39 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 304.0
HFD2_k127_400881_4 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 7.096e-264 825.0
HFD2_k127_400881_40 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 306.0
HFD2_k127_400881_41 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001297 290.0
HFD2_k127_400881_42 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000006027 260.0
HFD2_k127_400881_43 synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001268 265.0
HFD2_k127_400881_44 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000005363 276.0
HFD2_k127_400881_45 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000002334 256.0
HFD2_k127_400881_46 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000001028 242.0
HFD2_k127_400881_47 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000272 245.0
HFD2_k127_400881_48 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000865 240.0
HFD2_k127_400881_5 Protein kinase domain K12132 - 2.7.11.1 4.848e-240 770.0
HFD2_k127_400881_50 DNA polymerase III subunit epsilon K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000002025 242.0
HFD2_k127_400881_51 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000001345 237.0
HFD2_k127_400881_52 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003579 239.0
HFD2_k127_400881_53 PFAM GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000001248 224.0
HFD2_k127_400881_54 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000001057 214.0
HFD2_k127_400881_55 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000002993 228.0
HFD2_k127_400881_56 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.000000000000000000000000000000000000000000000000000000003015 210.0
HFD2_k127_400881_57 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000004163 207.0
HFD2_k127_400881_58 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000008297 204.0
HFD2_k127_400881_59 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000001142 205.0
HFD2_k127_400881_6 Involved in the tonB-independent uptake of proteins - - - 1.149e-232 747.0
HFD2_k127_400881_60 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000007295 202.0
HFD2_k127_400881_61 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000003512 190.0
HFD2_k127_400881_62 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000007295 183.0
HFD2_k127_400881_63 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.0000000000000000000000000000000000000000000005592 187.0
HFD2_k127_400881_64 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000001274 173.0
HFD2_k127_400881_65 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000003569 162.0
HFD2_k127_400881_66 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000003695 164.0
HFD2_k127_400881_67 Bacillithiol biosynthesis BshC K22136 - - 0.000000000000000000000000000000000000000009172 173.0
HFD2_k127_400881_68 WYL domain K13572 - - 0.0000000000000000000000000000000000000001651 165.0
HFD2_k127_400881_69 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000002601 167.0
HFD2_k127_400881_7 oligopeptide transporter, OPT family - - - 1.977e-218 696.0
HFD2_k127_400881_70 PIN domain - - - 0.000000000000000000000000000000000000004576 154.0
HFD2_k127_400881_71 PFAM von Willebrand factor type A - - - 0.00000000000000000000000000000001238 146.0
HFD2_k127_400881_72 Uncharacterized protein family UPF0029 - - - 0.0000000000000000000000000003862 129.0
HFD2_k127_400881_73 phosphorelay signal transduction system - - - 0.0000000000000000000000000006179 123.0
HFD2_k127_400881_74 - - - - 0.000000000000000000000000004658 126.0
HFD2_k127_400881_75 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000003709 111.0
HFD2_k127_400881_76 cell redox homeostasis - - - 0.0000000000000000000000008694 110.0
HFD2_k127_400881_77 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000001878 103.0
HFD2_k127_400881_78 peptidyl-tyrosine sulfation - - - 0.0000000000000000000001109 109.0
HFD2_k127_400881_79 Nitrate reductase delta subunit - - - 0.0000000000000000000007395 108.0
HFD2_k127_400881_8 PFAM amidohydrolase K01464 - 3.5.2.2 5.515e-195 626.0
HFD2_k127_400881_80 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000004868 94.0
HFD2_k127_400881_81 Haemolytic K08998 - - 0.000000000000000009357 86.0
HFD2_k127_400881_82 Preprotein translocase SecG subunit K03075 - - 0.0000000000000004969 84.0
HFD2_k127_400881_83 Family of unknown function (DUF5329) - - - 0.00000000000002779 84.0
HFD2_k127_400881_84 - - - - 0.000000000005337 72.0
HFD2_k127_400881_85 - - - - 0.0000000001092 73.0
HFD2_k127_400881_86 SnoaL-like domain K07023 - - 0.0000000001173 70.0
HFD2_k127_400881_87 Glutaredoxin K03676 - - 0.00000002486 56.0
HFD2_k127_400881_89 imidazolonepropionase activity - - - 0.00001158 48.0
HFD2_k127_400881_9 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 586.0
HFD2_k127_400881_90 transport - - - 0.000391 51.0
HFD2_k127_400881_91 DinB family - - - 0.0005631 49.0
HFD2_k127_400881_93 Putative adhesin - - - 0.0007705 50.0
HFD2_k127_400881_94 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.51 0.0008743 51.0
HFD2_k127_400881_95 domain protein - - - 0.0009835 51.0
HFD2_k127_4145927_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1062.0
HFD2_k127_4145927_1 Predicted Permease Membrane Region - - - 1.903e-204 651.0
HFD2_k127_4145927_10 glucose-6-phosphate isomerase activity K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000001542 190.0
HFD2_k127_4145927_11 - - - - 0.00000000000000000007613 97.0
HFD2_k127_4145927_2 Fumarase C C-terminus K01744 - 4.3.1.1 1.427e-195 619.0
HFD2_k127_4145927_3 Inorganic ion transport and metabolism K03319 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 509.0
HFD2_k127_4145927_4 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 510.0
HFD2_k127_4145927_5 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008782 440.0
HFD2_k127_4145927_6 Belongs to the asparaginase 1 family K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 410.0
HFD2_k127_4145927_7 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 408.0
HFD2_k127_4145927_8 - K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000002759 240.0
HFD2_k127_4145927_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003039 239.0
HFD2_k127_4199269_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 309.0
HFD2_k127_4199269_1 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 302.0
HFD2_k127_4199269_10 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000004077 132.0
HFD2_k127_4199269_11 - - - - 0.0000000000000000000000007538 115.0
HFD2_k127_4199269_12 PFAM ABC transporter related K02003 - - 0.000000001356 59.0
HFD2_k127_4199269_2 Pfam:Arch_ATPase K02450 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004701 284.0
HFD2_k127_4199269_3 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000874 281.0
HFD2_k127_4199269_4 sequence-specific DNA binding K00567,K13529,K15051 - 2.1.1.63,3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000001152 227.0
HFD2_k127_4199269_5 - - - - 0.0000000000000000000000000000000000000000000000000002063 194.0
HFD2_k127_4199269_6 Hydrolase - - - 0.000000000000000000000000000000000000000000000000006093 205.0
HFD2_k127_4199269_7 Chlorophyllase - - - 0.00000000000000000000000000000000000000008885 173.0
HFD2_k127_4199269_8 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000001296 160.0
HFD2_k127_4199269_9 - - - - 0.00000000000000000000000000000000000005666 154.0
HFD2_k127_4424934_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 5.429e-207 684.0
HFD2_k127_4424934_1 Pyruvate phosphate dikinase - - - 0.000000000000000000000000000000000000000000000007883 179.0
HFD2_k127_4424934_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000005112 152.0
HFD2_k127_4424934_3 Chromate resistance exported protein - - - 0.0000000000000000000000000002769 119.0
HFD2_k127_4424934_4 SMART phosphoesterase PA-phosphatase related - - - 0.00000000000000000000000004217 119.0
HFD2_k127_4424934_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.000000003427 70.0
HFD2_k127_4424934_6 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00002032 48.0
HFD2_k127_4424934_7 Outer membrane efflux protein - - - 0.0001474 54.0
HFD2_k127_4429594_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 606.0
HFD2_k127_4429594_1 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 509.0
HFD2_k127_4429594_10 PFAM Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000003357 165.0
HFD2_k127_4429594_11 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000625 149.0
HFD2_k127_4429594_12 Methyltransferase small domain - - - 0.00000000000000000000000000000000001802 148.0
HFD2_k127_4429594_13 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000009994 132.0
HFD2_k127_4429594_14 YqeY-like protein K09117 - - 0.00000000000000000000000000002769 123.0
HFD2_k127_4429594_15 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.0000000000000000000000000001882 128.0
HFD2_k127_4429594_16 protein with SCP PR1 domains - - - 0.00000000000000000001388 102.0
HFD2_k127_4429594_17 Phage late control gene D protein (GPD) - - - 0.00000000000000000004191 96.0
HFD2_k127_4429594_18 protein involved in tolerance to divalent cations K03926 GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 - 0.0000000000000000002048 93.0
HFD2_k127_4429594_19 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000001137 81.0
HFD2_k127_4429594_2 Selenocysteine-specific translation elongation factor K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 441.0
HFD2_k127_4429594_20 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.000000000000005832 83.0
HFD2_k127_4429594_21 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.0000005968 56.0
HFD2_k127_4429594_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 365.0
HFD2_k127_4429594_4 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 321.0
HFD2_k127_4429594_5 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007682 289.0
HFD2_k127_4429594_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008489 274.0
HFD2_k127_4429594_7 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000006453 265.0
HFD2_k127_4429594_8 Deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000002583 232.0
HFD2_k127_4429594_9 - - - - 0.000000000000000000000000000000000000000000001368 177.0
HFD2_k127_4430163_0 cellulose binding - - - 0.0 1188.0
HFD2_k127_4430163_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 7.161e-239 768.0
HFD2_k127_4430163_11 Protein of unknown function (DUF1003) - - - 0.0002207 45.0
HFD2_k127_4430163_2 Peptidase S46 - - - 1.484e-204 659.0
HFD2_k127_4430163_3 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 334.0
HFD2_k127_4430163_4 Type VI secretion system effector, Hcp K11903 - - 0.00000000000000000000000000000000000000000000000000431 190.0
HFD2_k127_4430163_5 Peptidase family M23 - - - 0.00000000000000000000000000000000678 140.0
HFD2_k127_4430163_6 Protein of unknown function (DUF2975) - - - 0.0000000000000000000000000000019 127.0
HFD2_k127_4430163_7 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000001434 114.0
HFD2_k127_4430163_8 Pfam Activator of Hsp90 ATPase - - - 0.000000000000000000000000005579 116.0
HFD2_k127_4430163_9 Tetratricopeptide repeat - - - 0.00000000011 68.0
HFD2_k127_4468231_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.055e-283 889.0
HFD2_k127_4468231_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00256 - 1.3.99.16 2.594e-247 790.0
HFD2_k127_4468231_10 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 393.0
HFD2_k127_4468231_11 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 385.0
HFD2_k127_4468231_12 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 387.0
HFD2_k127_4468231_13 Tryptophan halogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 389.0
HFD2_k127_4468231_14 Phosphofructokinase K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 371.0
HFD2_k127_4468231_15 glycosyl hydrolase, BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009262 383.0
HFD2_k127_4468231_16 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 362.0
HFD2_k127_4468231_17 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 339.0
HFD2_k127_4468231_18 cellulase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008905 371.0
HFD2_k127_4468231_19 Fungal trichothecene efflux pump (TRI12) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 334.0
HFD2_k127_4468231_2 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 6.79e-223 720.0
HFD2_k127_4468231_20 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 312.0
HFD2_k127_4468231_21 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 301.0
HFD2_k127_4468231_22 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 301.0
HFD2_k127_4468231_23 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001885 284.0
HFD2_k127_4468231_24 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004803 264.0
HFD2_k127_4468231_25 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007615 262.0
HFD2_k127_4468231_26 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005403 268.0
HFD2_k127_4468231_27 PFAM Hly-III family protein K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000333 244.0
HFD2_k127_4468231_28 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000003356 235.0
HFD2_k127_4468231_29 Protein of unknown function (DUF3455) - - - 0.00000000000000000000000000000000000000000000000000000000000437 215.0
HFD2_k127_4468231_3 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 617.0
HFD2_k127_4468231_30 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000001212 208.0
HFD2_k127_4468231_31 electron transport chain K00347,K03614 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000007391 228.0
HFD2_k127_4468231_32 TIGRFAM FeS assembly SUF system protein SufT - - - 0.0000000000000000000000000000000000000000000000000000001862 200.0
HFD2_k127_4468231_33 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000428 183.0
HFD2_k127_4468231_34 TIGRFAM SUF system FeS K04488 - - 0.0000000000000000000000000000000000000000000000001365 194.0
HFD2_k127_4468231_35 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000008021 151.0
HFD2_k127_4468231_36 - - - - 0.000000000000000000000000000000000000005011 151.0
HFD2_k127_4468231_37 - - - - 0.00000000000000000000000000000000000006805 152.0
HFD2_k127_4468231_38 - - - - 0.0000000000000000000000000000000000009987 142.0
HFD2_k127_4468231_39 MobA-like NTP transferase domain K07141,K19190 - 1.1.1.328,2.7.7.76 0.000000000000000000000000000000001382 140.0
HFD2_k127_4468231_4 Peptidase S9, prolyl oligopeptidase active site domain protein K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 598.0
HFD2_k127_4468231_40 glyoxalase III activity - - - 0.000000000000000000000000000000001418 139.0
HFD2_k127_4468231_41 - - - - 0.00000000000000000000000000000004553 135.0
HFD2_k127_4468231_42 Haem-degrading - - - 0.0000000000000000000000000000001204 131.0
HFD2_k127_4468231_43 Cupin domain - - - 0.0000000000000000000000000001232 121.0
HFD2_k127_4468231_44 HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) K01560 - 3.8.1.2 0.0000000000000000000000000006545 122.0
HFD2_k127_4468231_45 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000001023 129.0
HFD2_k127_4468231_46 - - - - 0.000000000000000000000001751 114.0
HFD2_k127_4468231_47 translation initiation factor activity K06996 - - 0.0000000000000000000000119 105.0
HFD2_k127_4468231_48 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000003321 113.0
HFD2_k127_4468231_49 TM2 domain - - - 0.000000000000000000000613 97.0
HFD2_k127_4468231_5 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 586.0
HFD2_k127_4468231_50 DinB family - - - 0.0000000000000000002299 94.0
HFD2_k127_4468231_51 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.0000000000000000003222 91.0
HFD2_k127_4468231_52 Acetamidase/Formamidase family - - - 0.00000000000000003888 91.0
HFD2_k127_4468231_53 YCII-related domain K09780 - - 0.000000000000001662 89.0
HFD2_k127_4468231_54 OsmC-like protein - - - 0.0000000000007519 73.0
HFD2_k127_4468231_55 hydrolases or acyltransferases alpha beta hydrolase superfamily - - - 0.000000000005489 78.0
HFD2_k127_4468231_56 - - - - 0.00000000007587 75.0
HFD2_k127_4468231_57 PFAM Tetratricopeptide repeat - - - 0.00000003395 66.0
HFD2_k127_4468231_58 DinB family - - - 0.0000166 49.0
HFD2_k127_4468231_59 - - - - 0.0001177 54.0
HFD2_k127_4468231_6 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 496.0
HFD2_k127_4468231_60 DinB family - - - 0.0003329 49.0
HFD2_k127_4468231_7 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 473.0
HFD2_k127_4468231_8 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 426.0
HFD2_k127_4468231_9 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009942 429.0
HFD2_k127_4523889_0 Sortilin, neurotensin receptor 3, - - - 0.0 1240.0
HFD2_k127_4523889_1 Fungalysin metallopeptidase (M36) - - - 4.763e-242 798.0
HFD2_k127_4523889_10 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 400.0
HFD2_k127_4523889_11 Thioredoxin-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 365.0
HFD2_k127_4523889_12 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 344.0
HFD2_k127_4523889_13 PFAM Branched-chain amino acid transport system permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 323.0
HFD2_k127_4523889_14 Mo-co oxidoreductase dimerisation domain K00387 - 1.8.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 299.0
HFD2_k127_4523889_15 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 290.0
HFD2_k127_4523889_16 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 301.0
HFD2_k127_4523889_17 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 293.0
HFD2_k127_4523889_18 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003967 290.0
HFD2_k127_4523889_19 PFAM ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009767 293.0
HFD2_k127_4523889_2 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 8.076e-199 634.0
HFD2_k127_4523889_20 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008995 306.0
HFD2_k127_4523889_21 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000006631 257.0
HFD2_k127_4523889_22 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009507 270.0
HFD2_k127_4523889_23 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000287 246.0
HFD2_k127_4523889_24 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002507 237.0
HFD2_k127_4523889_25 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K12267 GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000001714 223.0
HFD2_k127_4523889_26 - - - - 0.00000000000000000000000000000000000000000000000000000000002519 214.0
HFD2_k127_4523889_27 Protein of unknown function (DUF1211) - GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000000000000000000000002659 209.0
HFD2_k127_4523889_28 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000000000000000000000000004259 207.0
HFD2_k127_4523889_29 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000002785 198.0
HFD2_k127_4523889_3 Serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 599.0
HFD2_k127_4523889_30 PFAM CBS domain K04767 - - 0.000000000000000000000000000000000000000000000000000001013 199.0
HFD2_k127_4523889_31 AAA domain - - - 0.000000000000000000000000000000000000000000000003961 176.0
HFD2_k127_4523889_32 - - - - 0.000000000000000000000000000000000000000000000006907 185.0
HFD2_k127_4523889_33 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000001343 186.0
HFD2_k127_4523889_34 phosphorelay signal transduction system - - - 0.000000000000000000000000002215 118.0
HFD2_k127_4523889_35 COG1145 Ferredoxin - - - 0.000000000000000000000000003666 114.0
HFD2_k127_4523889_36 - - - - 0.00000000000000000000000002038 117.0
HFD2_k127_4523889_37 - - - - 0.00000000000000000000009056 104.0
HFD2_k127_4523889_38 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000002672 100.0
HFD2_k127_4523889_39 - - - - 0.0000000000000000002904 102.0
HFD2_k127_4523889_4 PFAM Pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 560.0
HFD2_k127_4523889_40 Transcriptional regulator, BadM Rrf2 family - - - 0.000000000000000001366 93.0
HFD2_k127_4523889_42 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000008396 91.0
HFD2_k127_4523889_43 hydroperoxide reductase activity - - - 0.000000000000002994 78.0
HFD2_k127_4523889_44 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.0000000000002963 77.0
HFD2_k127_4523889_45 peptidyl-tyrosine sulfation - - - 0.00000001973 62.0
HFD2_k127_4523889_47 PFAM Pyrrolo-quinoline quinone K00117 - 1.1.5.2 0.0000002047 62.0
HFD2_k127_4523889_48 Thioredoxin-like - - - 0.000002326 51.0
HFD2_k127_4523889_49 - - - - 0.0004168 51.0
HFD2_k127_4523889_5 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 462.0
HFD2_k127_4523889_6 Aldo Keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 458.0
HFD2_k127_4523889_7 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 453.0
HFD2_k127_4523889_8 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 396.0
HFD2_k127_4523889_9 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 412.0
HFD2_k127_4533968_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.275e-254 799.0
HFD2_k127_4533968_1 Protein kinase domain K12132 - 2.7.11.1 8.525e-210 682.0
HFD2_k127_4533968_10 deaminase K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000000000003498 220.0
HFD2_k127_4533968_11 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.0000000000000000000000000000000000000000000000000000001232 217.0
HFD2_k127_4533968_12 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000003521 211.0
HFD2_k127_4533968_13 Hep Hag repeat protein - GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000006384 203.0
HFD2_k127_4533968_14 - K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.000000000000000000000000000000000000000001022 161.0
HFD2_k127_4533968_15 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000003059 171.0
HFD2_k127_4533968_16 DinB family - - - 0.0000000000000000000000000000000002137 145.0
HFD2_k127_4533968_17 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000007127 138.0
HFD2_k127_4533968_18 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.000000000000000000000000000001305 130.0
HFD2_k127_4533968_19 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458 - 2.3.1.179 0.000000000000000000000000000002859 134.0
HFD2_k127_4533968_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.169e-205 662.0
HFD2_k127_4533968_20 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000005761 132.0
HFD2_k127_4533968_21 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000003021 121.0
HFD2_k127_4533968_22 response regulator containing a CheY-like receiver domain and a GGDEF domain K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.00000000000004814 81.0
HFD2_k127_4533968_23 Thioesterase-like superfamily K07107 - - 0.000000000000397 83.0
HFD2_k127_4533968_24 amine dehydrogenase activity - - - 0.00000000000583 78.0
HFD2_k127_4533968_25 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000001013 78.0
HFD2_k127_4533968_26 Belongs to the 'phage' integrase family - - - 0.0000000001189 67.0
HFD2_k127_4533968_27 - - - - 0.0000001398 62.0
HFD2_k127_4533968_28 - - - - 0.00005441 46.0
HFD2_k127_4533968_3 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 475.0
HFD2_k127_4533968_30 Forkhead associated domain - - - 0.0005588 52.0
HFD2_k127_4533968_31 YbbR-like protein - - - 0.0005671 52.0
HFD2_k127_4533968_4 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 459.0
HFD2_k127_4533968_5 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 359.0
HFD2_k127_4533968_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 345.0
HFD2_k127_4533968_7 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007343 312.0
HFD2_k127_4533968_8 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001028 265.0
HFD2_k127_4533968_9 calcium- and calmodulin-responsive adenylate cyclase activity K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000002733 248.0
HFD2_k127_4536878_0 Glycogen debranching enzyme - - - 0.0 1488.0
HFD2_k127_4536878_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1369.0
HFD2_k127_4536878_10 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 509.0
HFD2_k127_4536878_11 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 449.0
HFD2_k127_4536878_12 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 441.0
HFD2_k127_4536878_13 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 406.0
HFD2_k127_4536878_14 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 426.0
HFD2_k127_4536878_15 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 391.0
HFD2_k127_4536878_16 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 407.0
HFD2_k127_4536878_17 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 381.0
HFD2_k127_4536878_18 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 360.0
HFD2_k127_4536878_19 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 377.0
HFD2_k127_4536878_2 Protein kinase domain K12132 - 2.7.11.1 3.223e-266 851.0
HFD2_k127_4536878_20 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 372.0
HFD2_k127_4536878_21 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009474 350.0
HFD2_k127_4536878_22 protein kinase activity K01972,K02342,K04096 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 2.7.7.7,6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 358.0
HFD2_k127_4536878_23 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 345.0
HFD2_k127_4536878_24 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 328.0
HFD2_k127_4536878_25 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 331.0
HFD2_k127_4536878_26 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 297.0
HFD2_k127_4536878_27 Tricorn protease C1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004771 283.0
HFD2_k127_4536878_28 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005476 264.0
HFD2_k127_4536878_29 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001648 268.0
HFD2_k127_4536878_3 Berberine and berberine like - - - 6.582e-236 739.0
HFD2_k127_4536878_30 PFAM Acetyl-CoA hydrolase transferase K18118 - 2.8.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000003412 248.0
HFD2_k127_4536878_31 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000001291 242.0
HFD2_k127_4536878_32 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002734 232.0
HFD2_k127_4536878_33 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000004741 240.0
HFD2_k127_4536878_34 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000002587 226.0
HFD2_k127_4536878_35 Carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000003546 229.0
HFD2_k127_4536878_36 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000002327 220.0
HFD2_k127_4536878_37 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000002667 216.0
HFD2_k127_4536878_38 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000007966 214.0
HFD2_k127_4536878_39 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000002477 213.0
HFD2_k127_4536878_4 Alpha amylase, catalytic domain - - - 8.028e-231 722.0
HFD2_k127_4536878_40 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.000000000000000000000000000000000000000000000000000000003131 217.0
HFD2_k127_4536878_41 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000005511 197.0
HFD2_k127_4536878_42 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000003089 204.0
HFD2_k127_4536878_43 - - - - 0.00000000000000000000000000000000000000000000000002861 186.0
HFD2_k127_4536878_44 - - - - 0.00000000000000000000000000000000000000000000000007264 184.0
HFD2_k127_4536878_45 PFAM Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000001034 175.0
HFD2_k127_4536878_46 MaoC like domain K17865 - 4.2.1.55 0.0000000000000000000000000000000000000000000002747 171.0
HFD2_k127_4536878_47 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000001819 182.0
HFD2_k127_4536878_48 DinB family - - - 0.0000000000000000000000000000000000000000002038 166.0
HFD2_k127_4536878_49 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000008012 153.0
HFD2_k127_4536878_5 Involved in the tonB-independent uptake of proteins - - - 7.415e-215 695.0
HFD2_k127_4536878_51 outer membrane efflux protein - - - 0.0000000000000000000000000000000000248 155.0
HFD2_k127_4536878_52 MerR, DNA binding - - - 0.00000000000000000000000000000000007458 143.0
HFD2_k127_4536878_53 Cupin domain protein - - - 0.00000000000000000000000000000003447 135.0
HFD2_k127_4536878_54 ATP-independent chaperone mediated protein folding - - - 0.00000000000000000000000000000004276 142.0
HFD2_k127_4536878_55 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.000000000000000000000000000009077 135.0
HFD2_k127_4536878_56 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000001065 124.0
HFD2_k127_4536878_57 VIT family - - - 0.000000000000000000000000008211 122.0
HFD2_k127_4536878_58 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000008814 116.0
HFD2_k127_4536878_59 - - - - 0.0000000000000000000000007905 109.0
HFD2_k127_4536878_6 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 631.0
HFD2_k127_4536878_60 Yip1 domain - - - 0.000000000000000000001309 103.0
HFD2_k127_4536878_61 helix_turn_helix, Lux Regulon - - - 0.00000000000000000002684 106.0
HFD2_k127_4536878_62 - - - - 0.0000000000000000001601 91.0
HFD2_k127_4536878_63 - - - - 0.0000000000000000003396 95.0
HFD2_k127_4536878_64 membrane - - - 0.0000000000000000005627 95.0
HFD2_k127_4536878_65 PFAM Tetratricopeptide repeat - - - 0.000000000000003388 89.0
HFD2_k127_4536878_66 - - - - 0.00000000000002158 83.0
HFD2_k127_4536878_67 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000003338 78.0
HFD2_k127_4536878_68 domain, Protein - - - 0.0000000000001297 78.0
HFD2_k127_4536878_69 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000001128 70.0
HFD2_k127_4536878_7 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 565.0
HFD2_k127_4536878_70 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000001576 66.0
HFD2_k127_4536878_71 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000005251 74.0
HFD2_k127_4536878_72 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000891 75.0
HFD2_k127_4536878_73 protein import - - - 0.0000000003439 73.0
HFD2_k127_4536878_74 ACT domain - - - 0.0000000006076 68.0
HFD2_k127_4536878_76 SnoaL-like domain - - - 0.000002082 56.0
HFD2_k127_4536878_77 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.0007529 46.0
HFD2_k127_4536878_8 FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 542.0
HFD2_k127_4536878_9 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 529.0
HFD2_k127_455480_0 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 500.0
HFD2_k127_455480_1 Protein of unknown function (DUF4197) - - - 0.000000000000000000000000000000000000000000000000000000000000000003191 234.0
HFD2_k127_455480_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001975 227.0
HFD2_k127_455480_3 LysM domain - - - 0.0000000000000000000000000000000000000000000000000000000000007842 214.0
HFD2_k127_455480_4 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000008399 175.0
HFD2_k127_455480_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000001097 144.0
HFD2_k127_455480_6 DinB family - - - 0.000000000000000000000000000000000002623 145.0
HFD2_k127_455480_7 cell septum assembly - - - 0.00000000000000000000000000000003527 142.0
HFD2_k127_4683780_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.119e-280 881.0
HFD2_k127_4683780_1 Polysulphide reductase, NrfD K00185 - - 5.728e-215 691.0
HFD2_k127_4683780_10 - - - - 0.000000000000002125 83.0
HFD2_k127_4683780_2 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 439.0
HFD2_k127_4683780_3 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 413.0
HFD2_k127_4683780_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 410.0
HFD2_k127_4683780_5 signal sequence binding K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002905 287.0
HFD2_k127_4683780_6 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000001041 243.0
HFD2_k127_4683780_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000006383 229.0
HFD2_k127_4683780_8 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000000000000000006106 235.0
HFD2_k127_4683780_9 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.00000000000000000002421 93.0
HFD2_k127_4702849_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 522.0
HFD2_k127_4702849_1 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 377.0
HFD2_k127_4702849_11 integral membrane protein - - - 0.00000000000000000002028 106.0
HFD2_k127_4702849_2 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002509 274.0
HFD2_k127_4702849_3 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000008845 267.0
HFD2_k127_4702849_4 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009403 259.0
HFD2_k127_4702849_5 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000000000000000000000000000000001762 242.0
HFD2_k127_4702849_6 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000004483 228.0
HFD2_k127_4702849_7 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000002036 225.0
HFD2_k127_4702849_8 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000001781 209.0
HFD2_k127_4702849_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000205 183.0
HFD2_k127_471771_0 Urocanase C-terminal domain K01712 - 4.2.1.49 9.978e-254 794.0
HFD2_k127_471771_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 484.0
HFD2_k127_471771_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 418.0
HFD2_k127_471771_3 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 349.0
HFD2_k127_471771_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000212 231.0
HFD2_k127_471771_5 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000001775 209.0
HFD2_k127_471771_6 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 0.00000000000000000000000000000000000000000000000000003539 216.0
HFD2_k127_471771_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000002749 167.0
HFD2_k127_471771_8 Bacterial Ig-like domain (group 3) K01337,K20276,K21449 - 3.4.21.50 0.00000000000000000000000000000000000003771 159.0
HFD2_k127_471771_9 Protein of unknown function (DUF465) K09794 - - 0.0008791 47.0
HFD2_k127_4741326_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 487.0
HFD2_k127_4741326_1 Glycosyl transferase family 2 K10012,K20534 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 389.0
HFD2_k127_4741326_2 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 331.0
HFD2_k127_4741326_3 Formyl transferase K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000003108 276.0
HFD2_k127_4741326_4 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000001098 234.0
HFD2_k127_4741326_5 Transport permease protein K09688,K09690 - - 0.000000000000000000000000000000000000001352 159.0
HFD2_k127_4741326_6 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.000000000000000000000001585 119.0
HFD2_k127_4741326_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000002929 79.0
HFD2_k127_4816864_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 7.177e-318 1002.0
HFD2_k127_4816864_1 Hydrolase CocE NonD family - - - 1.017e-299 934.0
HFD2_k127_4816864_10 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000000002949 148.0
HFD2_k127_4816864_11 endonuclease III K01247 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.21 0.0000000000000000000000000000000000001577 154.0
HFD2_k127_4816864_12 coenzyme F420 binding K07226 - - 0.0000000000000000000000000000000001674 143.0
HFD2_k127_4816864_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000001572 132.0
HFD2_k127_4816864_14 - - - - 0.00000000000000000005004 92.0
HFD2_k127_4816864_15 Acetyl xylan esterase (AXE1) - - - 0.0000000004318 65.0
HFD2_k127_4816864_16 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000003721 52.0
HFD2_k127_4816864_17 - - - - 0.00000858 54.0
HFD2_k127_4816864_18 Participates in both transcription termination and antitermination K02600 - - 0.00001966 52.0
HFD2_k127_4816864_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00262 - 1.4.1.4 1.102e-248 773.0
HFD2_k127_4816864_3 heavy metal translocating P-type ATPase K01533 - 3.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 606.0
HFD2_k127_4816864_4 glycosyl hydrolase, BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 393.0
HFD2_k127_4816864_5 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 354.0
HFD2_k127_4816864_6 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 324.0
HFD2_k127_4816864_7 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000000000000000006058 198.0
HFD2_k127_4816864_8 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000029 174.0
HFD2_k127_4816864_9 Protein of unknown function (DUF1569) - - - 0.0000000000000000000000000000000000000000001982 162.0
HFD2_k127_4823395_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 487.0
HFD2_k127_4823395_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 299.0
HFD2_k127_4823395_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 292.0
HFD2_k127_4828584_0 Peptidase M14, carboxypeptidase A - - - 0.0 1314.0
HFD2_k127_4828584_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1049.0
HFD2_k127_4828584_10 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 530.0
HFD2_k127_4828584_11 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 493.0
HFD2_k127_4828584_12 adenylosuccinate lyase K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 497.0
HFD2_k127_4828584_13 AAA ATPase, central domain protein K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 473.0
HFD2_k127_4828584_14 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 463.0
HFD2_k127_4828584_15 Mg chelatase-like protein K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 463.0
HFD2_k127_4828584_16 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 456.0
HFD2_k127_4828584_17 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 432.0
HFD2_k127_4828584_18 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004323 430.0
HFD2_k127_4828584_19 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 425.0
HFD2_k127_4828584_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 8.514e-249 796.0
HFD2_k127_4828584_20 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 403.0
HFD2_k127_4828584_21 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 407.0
HFD2_k127_4828584_22 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 407.0
HFD2_k127_4828584_23 Dehydrogenase K00030,K00052 - 1.1.1.41,1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 402.0
HFD2_k127_4828584_24 Ornithine cyclodeaminase/mu-crystallin family K01750,K19244 - 1.4.1.1,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 370.0
HFD2_k127_4828584_25 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009877 359.0
HFD2_k127_4828584_26 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 354.0
HFD2_k127_4828584_27 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 355.0
HFD2_k127_4828584_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 349.0
HFD2_k127_4828584_29 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009404 349.0
HFD2_k127_4828584_3 Heat shock 70 kDa protein K04043 - - 1.529e-232 739.0
HFD2_k127_4828584_30 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 344.0
HFD2_k127_4828584_31 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 357.0
HFD2_k127_4828584_32 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 344.0
HFD2_k127_4828584_33 Histidine kinase-like ATPases K01768,K02488,K17763 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 346.0
HFD2_k127_4828584_34 alpha beta alpha domain I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 341.0
HFD2_k127_4828584_35 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 343.0
HFD2_k127_4828584_36 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 321.0
HFD2_k127_4828584_37 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 325.0
HFD2_k127_4828584_38 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 313.0
HFD2_k127_4828584_39 formate dehydrogenase (NAD+) activity K00336,K18006 - 1.12.1.2,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 332.0
HFD2_k127_4828584_4 PFAM Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 1.78e-205 667.0
HFD2_k127_4828584_40 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 301.0
HFD2_k127_4828584_41 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 301.0
HFD2_k127_4828584_42 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009631 304.0
HFD2_k127_4828584_43 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000072 264.0
HFD2_k127_4828584_44 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007442 270.0
HFD2_k127_4828584_45 CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001767 269.0
HFD2_k127_4828584_46 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009852 264.0
HFD2_k127_4828584_47 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000149 262.0
HFD2_k127_4828584_48 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000001149 246.0
HFD2_k127_4828584_49 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000003886 244.0
HFD2_k127_4828584_5 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.415e-199 633.0
HFD2_k127_4828584_50 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000001167 239.0
HFD2_k127_4828584_51 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000025 231.0
HFD2_k127_4828584_52 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000003376 235.0
HFD2_k127_4828584_53 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000002454 226.0
HFD2_k127_4828584_54 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000005792 197.0
HFD2_k127_4828584_55 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000001079 184.0
HFD2_k127_4828584_56 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000003155 187.0
HFD2_k127_4828584_57 Acyl transferase domain K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000586 184.0
HFD2_k127_4828584_58 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000001292 173.0
HFD2_k127_4828584_59 Domain of unknown function (DUF3473) - - - 0.000000000000000000000000000000000000000000002777 177.0
HFD2_k127_4828584_6 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 1.967e-198 637.0
HFD2_k127_4828584_60 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000004697 169.0
HFD2_k127_4828584_61 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000001456 167.0
HFD2_k127_4828584_62 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000000000000000003899 169.0
HFD2_k127_4828584_63 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000001524 162.0
HFD2_k127_4828584_64 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000001811 154.0
HFD2_k127_4828584_65 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000002927 151.0
HFD2_k127_4828584_66 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000001512 147.0
HFD2_k127_4828584_67 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000002909 156.0
HFD2_k127_4828584_68 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000225 156.0
HFD2_k127_4828584_69 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.000000000000000000000000000000000006323 149.0
HFD2_k127_4828584_7 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 636.0
HFD2_k127_4828584_70 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000005178 143.0
HFD2_k127_4828584_71 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000002363 138.0
HFD2_k127_4828584_72 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000001312 121.0
HFD2_k127_4828584_73 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000001385 124.0
HFD2_k127_4828584_74 Ribosomal protein L11 methyltransferase K02687 - - 0.000000000000000000000000001112 123.0
HFD2_k127_4828584_75 Belongs to the ompA family - - - 0.000000000000000000000000005785 126.0
HFD2_k127_4828584_76 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000007647 109.0
HFD2_k127_4828584_77 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.0000000000000000000000001914 112.0
HFD2_k127_4828584_78 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000003906 118.0
HFD2_k127_4828584_79 - - - - 0.0000000000000000000000044 106.0
HFD2_k127_4828584_8 PFAM peptidase M61 - - - 7.192e-194 625.0
HFD2_k127_4828584_80 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000002049 107.0
HFD2_k127_4828584_81 Rossmann-like domain - - - 0.0000000000000000000006203 106.0
HFD2_k127_4828584_82 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000001165 100.0
HFD2_k127_4828584_83 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000005743 98.0
HFD2_k127_4828584_84 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.00000000000000002928 90.0
HFD2_k127_4828584_85 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000003048 91.0
HFD2_k127_4828584_86 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000002859 78.0
HFD2_k127_4828584_87 SMART Tetratricopeptide - - - 0.000000000000004422 83.0
HFD2_k127_4828584_88 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000003756 79.0
HFD2_k127_4828584_89 - - - - 0.000000000003055 72.0
HFD2_k127_4828584_9 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 522.0
HFD2_k127_4828584_90 - - - - 0.00000000002854 73.0
HFD2_k127_4828584_91 Glycosyltransferase family 87 - - - 0.0000000001572 72.0
HFD2_k127_4828584_92 Mitochondrial biogenesis AIM24 - - - 0.0000000002813 72.0
HFD2_k127_4828584_93 Ferric siderophore transporter, periplasmic energy transduction protein TonB K03832 - - 0.000000001176 70.0
HFD2_k127_4828584_94 Modulates RecA activity K03565 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000001407 71.0
HFD2_k127_4828584_95 tRNA wobble adenosine to inosine editing - - - 0.000000003769 61.0
HFD2_k127_4828584_96 Yip1 domain - - - 0.000000006237 67.0
HFD2_k127_4828584_97 Belongs to the UPF0109 family K06960 GO:0008150,GO:0040007 - 0.00000001377 63.0
HFD2_k127_4828584_98 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity K02372 - 4.2.1.59 0.00000002173 61.0
HFD2_k127_4828584_99 monooxygenase activity - - - 0.000224 48.0
HFD2_k127_4962836_0 Prokaryotic cytochrome b561 - - - 0.0 1096.0
HFD2_k127_4962836_1 Cation transporter/ATPase, N-terminus - - - 9.524e-244 780.0
HFD2_k127_4962836_10 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 377.0
HFD2_k127_4962836_11 COG0644 Dehydrogenases (flavoproteins) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 352.0
HFD2_k127_4962836_12 Cytochrome c554 and c-prime K03620 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 367.0
HFD2_k127_4962836_13 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 330.0
HFD2_k127_4962836_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005831 299.0
HFD2_k127_4962836_15 PFAM ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005207 272.0
HFD2_k127_4962836_16 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000000003944 213.0
HFD2_k127_4962836_17 14-dihydroxy-2-naphthoate octaprenyltransferase K02548 - 2.5.1.74 0.000000000000000000000000000000000000000000000000003245 193.0
HFD2_k127_4962836_18 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.0000000000000000000000000000000000000003073 158.0
HFD2_k127_4962836_19 Adenylylsulphate kinase K00860 - 2.7.1.25 0.00000000000000000000000001543 117.0
HFD2_k127_4962836_2 formate dehydrogenase - - - 1.177e-237 757.0
HFD2_k127_4962836_20 Cbs domain K04767 - - 0.00000000000000000000772 98.0
HFD2_k127_4962836_21 Universal stress protein - - - 0.0000000000000000000138 100.0
HFD2_k127_4962836_22 Universal stress protein - - - 0.0000000000000000008343 94.0
HFD2_k127_4962836_23 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000002482 91.0
HFD2_k127_4962836_24 - - - - 0.0000000001888 74.0
HFD2_k127_4962836_3 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 617.0
HFD2_k127_4962836_4 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 584.0
HFD2_k127_4962836_5 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 549.0
HFD2_k127_4962836_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 472.0
HFD2_k127_4962836_7 PFAM S-adenosylmethionine synthetase (MAT) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 457.0
HFD2_k127_4962836_8 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 416.0
HFD2_k127_4962836_9 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 379.0
HFD2_k127_5302068_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 322.0
HFD2_k127_5302068_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000245 221.0
HFD2_k127_5302068_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000001653 124.0
HFD2_k127_5302068_3 alginic acid biosynthetic process - - - 0.0000000000000000003664 89.0
HFD2_k127_5302068_4 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000001655 91.0
HFD2_k127_5369734_0 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0016829,GO:0016830,GO:0016833 4.1.3.1 0.0 1182.0
HFD2_k127_5369734_1 CoA binding domain K01905,K22224 - 6.2.1.13 4.24e-197 634.0
HFD2_k127_5369734_2 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000007441 180.0
HFD2_k127_5375344_0 E1-E2 ATPase K01533 - 3.6.3.4 4.969e-315 980.0
HFD2_k127_5375344_1 Carbohydrate phosphorylase K00688 - 2.4.1.1 8.704e-269 843.0
HFD2_k127_5375344_2 Glycosyl hydrolase family 57 - - - 0.00000000000000000000000000000000000000000000000000001083 193.0
HFD2_k127_5375344_3 pfam yhs - - - 0.0000000000003391 70.0
HFD2_k127_5375344_4 - - - - 0.0000000002711 66.0
HFD2_k127_5375344_5 Protein of unknown function (DUF2933) - - - 0.0002916 46.0
HFD2_k127_538725_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 432.0
HFD2_k127_538725_1 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 424.0
HFD2_k127_538725_2 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001197 265.0
HFD2_k127_538725_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000000000000000002715 181.0
HFD2_k127_5406390_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1680.0
HFD2_k127_5406390_1 Insulinase (Peptidase family M16) K07263 - - 0.0 1248.0
HFD2_k127_5406390_10 benzoyl-CoA reductase K04113 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 559.0
HFD2_k127_5406390_11 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 559.0
HFD2_k127_5406390_12 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 529.0
HFD2_k127_5406390_13 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 534.0
HFD2_k127_5406390_14 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 533.0
HFD2_k127_5406390_15 Belongs to the HypD family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 502.0
HFD2_k127_5406390_16 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 472.0
HFD2_k127_5406390_17 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007291 471.0
HFD2_k127_5406390_18 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 460.0
HFD2_k127_5406390_19 BadF/BadG/BcrA/BcrD ATPase family K04114 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008554 458.0
HFD2_k127_5406390_2 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 8.247e-271 858.0
HFD2_k127_5406390_20 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 446.0
HFD2_k127_5406390_21 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 430.0
HFD2_k127_5406390_22 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 432.0
HFD2_k127_5406390_23 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007439 422.0
HFD2_k127_5406390_24 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 417.0
HFD2_k127_5406390_25 benzoyl-CoA reductase K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 422.0
HFD2_k127_5406390_26 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 403.0
HFD2_k127_5406390_27 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 394.0
HFD2_k127_5406390_28 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 392.0
HFD2_k127_5406390_29 Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 389.0
HFD2_k127_5406390_3 Succinyl-CoA ligase like flavodoxin domain - - - 1.102e-270 859.0
HFD2_k127_5406390_30 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 368.0
HFD2_k127_5406390_31 Zinc-binding dehydrogenase K07538 - 1.1.1.368 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004306 360.0
HFD2_k127_5406390_32 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 349.0
HFD2_k127_5406390_33 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 313.0
HFD2_k127_5406390_34 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 301.0
HFD2_k127_5406390_35 PFAM Rhomboid family protein K07059 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004145 276.0
HFD2_k127_5406390_36 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002849 276.0
HFD2_k127_5406390_37 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001525 258.0
HFD2_k127_5406390_38 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000002304 259.0
HFD2_k127_5406390_39 PFAM Phosphomethylpyrimidine kinase type-1 K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000001164 249.0
HFD2_k127_5406390_4 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 1.868e-264 824.0
HFD2_k127_5406390_40 Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000006708 220.0
HFD2_k127_5406390_41 COG1943 Transposase and inactivated derivatives K07491 - - 0.0000000000000000000000000000000000000000000000000000000007022 213.0
HFD2_k127_5406390_42 KR domain - - - 0.000000000000000000000000000000000000000000000000000000002853 210.0
HFD2_k127_5406390_43 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000295 226.0
HFD2_k127_5406390_44 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000000000000000000000003957 207.0
HFD2_k127_5406390_45 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000002769 206.0
HFD2_k127_5406390_46 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000001598 199.0
HFD2_k127_5406390_47 PFAM glycosyl transferase family 2 K14597 - - 0.000000000000000000000000000000000000000000000000001786 197.0
HFD2_k127_5406390_48 PFAM iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000001189 188.0
HFD2_k127_5406390_49 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000002511 201.0
HFD2_k127_5406390_5 X-Pro dipeptidyl-peptidase (S15 family) - - - 5.62e-230 730.0
HFD2_k127_5406390_50 Domain of unknown function (DUF4405) - - - 0.00000000000000000000000000000000000000000000000122 192.0
HFD2_k127_5406390_51 iron-sulfur cluster assembly K07400 - - 0.000000000000000000000000000000000000000000008755 171.0
HFD2_k127_5406390_52 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000002291 166.0
HFD2_k127_5406390_53 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.0000000000000000000000000000000000000006153 158.0
HFD2_k127_5406390_54 PFAM Enoyl-CoA hydratase isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000001387 142.0
HFD2_k127_5406390_55 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.000000000000000000000000000003029 128.0
HFD2_k127_5406390_56 Universal stress protein family - - - 0.000000000000000000000000000004504 123.0
HFD2_k127_5406390_57 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000004262 125.0
HFD2_k127_5406390_58 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000005773 124.0
HFD2_k127_5406390_59 Biogenesis protein - - - 0.0000000000000000000000000003431 123.0
HFD2_k127_5406390_6 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 7.294e-204 654.0
HFD2_k127_5406390_60 carbon dioxide binding K04653,K04654 - - 0.00000000000000000000000001717 127.0
HFD2_k127_5406390_61 PFAM CBS domain containing protein K07168 - - 0.00000000000000000000000005262 117.0
HFD2_k127_5406390_62 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000001763 121.0
HFD2_k127_5406390_63 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000002515 121.0
HFD2_k127_5406390_64 Dodecin K09165 - - 0.000000000000000000000006282 102.0
HFD2_k127_5406390_65 Pas domain - - - 0.0000000000000000000003259 104.0
HFD2_k127_5406390_66 Calcineurin-like phosphoesterase - - - 0.0000000000000000000006257 108.0
HFD2_k127_5406390_67 nickel cation binding K04651 - - 0.000000000000000000004 97.0
HFD2_k127_5406390_68 CBS domain - - - 0.00000000000000000005992 98.0
HFD2_k127_5406390_69 - - - - 0.0000000000000000001509 100.0
HFD2_k127_5406390_7 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 594.0
HFD2_k127_5406390_70 Protein of unknown function (DUF962) - - - 0.0000000000000000007368 92.0
HFD2_k127_5406390_71 Bacterial PH domain K08981 - - 0.00000000000000001204 93.0
HFD2_k127_5406390_72 Heavy-metal resistance - - - 0.0000000000000001864 89.0
HFD2_k127_5406390_73 Putative phosphatase (DUF442) - - - 0.0000000000000003983 85.0
HFD2_k127_5406390_74 CBS domain containing protein - - - 0.00000000000009493 80.0
HFD2_k127_5406390_75 Family of unknown function (DUF5335) - - - 0.00000000004386 70.0
HFD2_k127_5406390_76 helix_turn_helix, Lux Regulon K07684 - - 0.0000000007005 68.0
HFD2_k127_5406390_77 Universal stress protein family - - - 0.0000000007877 70.0
HFD2_k127_5406390_78 Universal stress protein - - - 0.00000007401 64.0
HFD2_k127_5406390_79 mRNA catabolic process K06950 - - 0.000001113 59.0
HFD2_k127_5406390_8 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 588.0
HFD2_k127_5406390_80 Tetratricopeptide repeat domain protein - - - 0.000006667 58.0
HFD2_k127_5406390_81 cytochrome C - - - 0.000007682 55.0
HFD2_k127_5406390_83 Universal stress protein - - - 0.0001401 51.0
HFD2_k127_5406390_84 - - - - 0.0004394 53.0
HFD2_k127_5406390_9 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 570.0
HFD2_k127_54178_0 Large extracellular alpha-helical protein - - - 0.0 2068.0
HFD2_k127_54178_1 DEAD DEAH box helicase K03724 - - 0.0 1345.0
HFD2_k127_54178_10 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 473.0
HFD2_k127_54178_11 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 441.0
HFD2_k127_54178_12 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 442.0
HFD2_k127_54178_13 Bacterial sugar transferase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 415.0
HFD2_k127_54178_14 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 415.0
HFD2_k127_54178_15 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 410.0
HFD2_k127_54178_16 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 405.0
HFD2_k127_54178_17 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 400.0
HFD2_k127_54178_18 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 365.0
HFD2_k127_54178_19 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 360.0
HFD2_k127_54178_2 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1112.0
HFD2_k127_54178_20 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 381.0
HFD2_k127_54178_21 Domain of unknown function (DUF1972) K12996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 354.0
HFD2_k127_54178_22 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 357.0
HFD2_k127_54178_23 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 366.0
HFD2_k127_54178_24 Protein of unknown function (DUF2950) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 358.0
HFD2_k127_54178_25 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 344.0
HFD2_k127_54178_26 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 323.0
HFD2_k127_54178_27 Dihydroorotate dehydrogenase K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 328.0
HFD2_k127_54178_28 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008196 338.0
HFD2_k127_54178_29 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007103 311.0
HFD2_k127_54178_3 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.925e-281 882.0
HFD2_k127_54178_30 Allophanate hydrolase subunit 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001717 313.0
HFD2_k127_54178_31 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001112 279.0
HFD2_k127_54178_32 ABC transporter permease K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002164 279.0
HFD2_k127_54178_33 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002288 277.0
HFD2_k127_54178_34 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009703 280.0
HFD2_k127_54178_35 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001477 269.0
HFD2_k127_54178_36 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001759 262.0
HFD2_k127_54178_37 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002706 246.0
HFD2_k127_54178_38 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000003807 242.0
HFD2_k127_54178_39 Methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000002269 236.0
HFD2_k127_54178_4 PFAM multicopper oxidase type 2 - - - 1.353e-237 759.0
HFD2_k127_54178_40 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000007217 237.0
HFD2_k127_54178_41 regulatory protein TetR - - - 0.000000000000000000000000000000000000000000000000000000000000151 217.0
HFD2_k127_54178_42 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000001618 233.0
HFD2_k127_54178_43 Hsp70 protein - - - 0.0000000000000000000000000000000000000000000000000000000004346 220.0
HFD2_k127_54178_44 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000005863 206.0
HFD2_k127_54178_45 Hsp70 protein - - - 0.0000000000000000000000000000000000000000000000000000000009463 218.0
HFD2_k127_54178_46 COG2202 FOG PAS PAC domain - - - 0.000000000000000000000000000000000000000000000000000007813 214.0
HFD2_k127_54178_47 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000002091 201.0
HFD2_k127_54178_48 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000021 195.0
HFD2_k127_54178_49 PSP1 C-terminal conserved region - - - 0.000000000000000000000000000000000000000000000000000106 194.0
HFD2_k127_54178_5 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 608.0
HFD2_k127_54178_50 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000002401 192.0
HFD2_k127_54178_51 - - - - 0.000000000000000000000000000000000000000000000001417 199.0
HFD2_k127_54178_52 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000001999 181.0
HFD2_k127_54178_53 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000002261 178.0
HFD2_k127_54178_54 DinB family - - - 0.00000000000000000000000000000000000000000000001435 175.0
HFD2_k127_54178_55 acetyltransferase - - - 0.0000000000000000000000000000000000000000002787 166.0
HFD2_k127_54178_56 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.0000000000000000000000000000000000000000008553 171.0
HFD2_k127_54178_57 Oxidoreductase NAD-binding domain K02823 - - 0.000000000000000000000000000000000000000001164 166.0
HFD2_k127_54178_58 Short-chain dehydrogenase reductase SDR K07535 - - 0.000000000000000000000000000000000000000005327 178.0
HFD2_k127_54178_59 Penicillinase repressor - - - 0.0000000000000000000000000000000000000001261 154.0
HFD2_k127_54178_6 Catalyzes the oxidation of L-aspartate to iminoaspartate K00244,K00278 GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.3.5.4,1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 592.0
HFD2_k127_54178_60 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000001646 153.0
HFD2_k127_54178_62 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000009694 153.0
HFD2_k127_54178_63 DinB family - - - 0.000000000000000000000000000000000007507 143.0
HFD2_k127_54178_64 - - - - 0.00000000000000000000000000000000001222 150.0
HFD2_k127_54178_65 Glycosyltransferase like family 2 K07011 - - 0.0000000000000000000000000000000002532 144.0
HFD2_k127_54178_66 photosystem II stabilization - - - 0.00000000000000000000000000000001021 143.0
HFD2_k127_54178_67 Pfam Response regulator receiver K11443 - - 0.00000000000000000000000000000002913 145.0
HFD2_k127_54178_68 Mannosyltransferase (PIG-V) - - - 0.00000000000000000000000000000177 138.0
HFD2_k127_54178_69 Hfq protein - - - 0.00000000000000000000000000000634 122.0
HFD2_k127_54178_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 547.0
HFD2_k127_54178_70 Glycosyl transferase, family 2 K07011 - - 0.000000000000000000000000000167 132.0
HFD2_k127_54178_71 MgtC family K07507 - - 0.0000000000000000000000000006425 118.0
HFD2_k127_54178_72 cheY-homologous receiver domain - - - 0.00000000000000000000000001165 114.0
HFD2_k127_54178_73 esterase - - - 0.00000000000000000000000001818 120.0
HFD2_k127_54178_74 - - - - 0.000000000000000000000004926 104.0
HFD2_k127_54178_75 - - - - 0.000000000000000000000007396 104.0
HFD2_k127_54178_76 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000004285 98.0
HFD2_k127_54178_77 - - - - 0.00000000000001733 78.0
HFD2_k127_54178_78 peptidase inhibitor activity - - - 0.000000000001353 79.0
HFD2_k127_54178_8 peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 531.0
HFD2_k127_54178_81 - - - - 0.0000001578 61.0
HFD2_k127_54178_82 peptidyl-tyrosine sulfation - - - 0.0000001643 65.0
HFD2_k127_54178_83 DNA uptake protein and related DNA-binding K02237 - - 0.0000002553 63.0
HFD2_k127_54178_84 - - - - 0.000003527 58.0
HFD2_k127_54178_85 Protein tyrosine kinase K12132 - 2.7.11.1 0.000005951 60.0
HFD2_k127_54178_87 Histidine kinase - - - 0.0001093 52.0
HFD2_k127_54178_88 peptidyl-tyrosine sulfation - - - 0.0006492 53.0
HFD2_k127_54178_9 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006186 456.0
HFD2_k127_5462318_0 Belongs to the aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 1.994e-205 659.0
HFD2_k127_5462318_1 PFAM Amidohydrolase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 449.0
HFD2_k127_5462318_2 Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 439.0
HFD2_k127_5462318_3 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 369.0
HFD2_k127_5462318_4 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 349.0
HFD2_k127_5462318_5 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 325.0
HFD2_k127_5462318_6 Polymer-forming cytoskeletal - - - 0.000000000000000000004512 99.0
HFD2_k127_5470157_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1561.0
HFD2_k127_5470157_1 Amidase K01426 - 3.5.1.4 5.454e-216 686.0
HFD2_k127_5470157_10 Phenazine biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008088 340.0
HFD2_k127_5470157_11 trimming of terminal mannose on B branch K10085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 329.0
HFD2_k127_5470157_12 Uncharacterized conserved protein (COG2071) K09166 - - 0.000000000000000000000000000000000000000000000000000000000000000000006308 246.0
HFD2_k127_5470157_13 Receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000001992 239.0
HFD2_k127_5470157_14 PFAM phospholipase Carboxylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005421 236.0
HFD2_k127_5470157_15 Glycosyl hydrolase family 47 K01230 - 3.2.1.113 0.000000000000000000000000000000000000000000000000000000000000001948 224.0
HFD2_k127_5470157_16 Nitronate monooxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000001087 221.0
HFD2_k127_5470157_17 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000003824 205.0
HFD2_k127_5470157_18 PFAM OsmC family protein K04063 - - 0.00000000000000000000000000000000000000000000003346 191.0
HFD2_k127_5470157_19 DinB superfamily - - - 0.000000000000000000000000000000000000007235 152.0
HFD2_k127_5470157_2 peptidyl-tyrosine sulfation - - - 3.553e-213 682.0
HFD2_k127_5470157_20 cellulase activity - - - 0.000000000000000000000000000000000002108 157.0
HFD2_k127_5470157_21 Tyrosine phosphatase family - - - 0.000000000000000000000000000000000008876 150.0
HFD2_k127_5470157_22 - - - - 0.000000000000000000000008838 105.0
HFD2_k127_5470157_23 Transcriptional regulator - - - 0.0000000000000000001689 97.0
HFD2_k127_5470157_24 domain, Protein K12685,K16785,K16786,K16787 - - 0.0000000000001231 84.0
HFD2_k127_5470157_26 Lipid A 3-O-deacylase (PagL) - - - 0.0002651 49.0
HFD2_k127_5470157_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 584.0
HFD2_k127_5470157_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 511.0
HFD2_k127_5470157_5 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 497.0
HFD2_k127_5470157_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 454.0
HFD2_k127_5470157_7 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 452.0
HFD2_k127_5470157_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 441.0
HFD2_k127_5470157_9 serine threonine protein kinase K00870,K12132 - 2.7.1.37,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 459.0
HFD2_k127_5481223_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.965e-248 790.0
HFD2_k127_5481223_1 PFAM peptidase M13 K07386 - - 6.3e-220 702.0
HFD2_k127_5481223_10 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000000000000000000000000000000000000008605 200.0
HFD2_k127_5481223_11 Acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000519 204.0
HFD2_k127_5481223_12 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000000000000002612 171.0
HFD2_k127_5481223_13 SMART protein phosphatase 2C domain protein - - - 0.0000000000000000000000000000000000000006197 163.0
HFD2_k127_5481223_14 RNA recognition motif - - - 0.0000000000000000000000002033 114.0
HFD2_k127_5481223_16 PFAM thioesterase superfamily protein K07107 - - 0.0000000000004087 75.0
HFD2_k127_5481223_2 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 474.0
HFD2_k127_5481223_3 Lipase maturation factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 462.0
HFD2_k127_5481223_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 408.0
HFD2_k127_5481223_5 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 349.0
HFD2_k127_5481223_6 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006681 300.0
HFD2_k127_5481223_7 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001645 256.0
HFD2_k127_5481223_8 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000001377 262.0
HFD2_k127_5481223_9 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001893 265.0
HFD2_k127_5618755_0 Oligoendopeptidase f - - - 4.549e-255 804.0
HFD2_k127_5618755_1 protein kinase activity - - - 1.217e-196 644.0
HFD2_k127_5618755_10 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 341.0
HFD2_k127_5618755_11 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 313.0
HFD2_k127_5618755_12 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006344 306.0
HFD2_k127_5618755_13 Carbohydrate family 9 binding domain-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001769 289.0
HFD2_k127_5618755_14 dihydrofolate reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000785 232.0
HFD2_k127_5618755_15 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - - 0.00000000000000000000000000000000000000000000000000001539 216.0
HFD2_k127_5618755_16 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000001626 154.0
HFD2_k127_5618755_17 pfam nudix - - - 0.00000000000000000000000000000000004596 142.0
HFD2_k127_5618755_19 - - - - 0.000000000000000000000000000004901 128.0
HFD2_k127_5618755_2 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 590.0
HFD2_k127_5618755_20 Transcriptional regulator K07729 - - 0.00000000000000000000002641 103.0
HFD2_k127_5618755_21 Lysin motif - - - 0.000000000000000002419 95.0
HFD2_k127_5618755_22 PFAM S23 ribosomal protein - - - 0.000000000000000009418 94.0
HFD2_k127_5618755_23 Carbohydrate family 9 binding domain-like - - - 0.00000001337 64.0
HFD2_k127_5618755_24 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000002884 50.0
HFD2_k127_5618755_25 - - - - 0.000026 53.0
HFD2_k127_5618755_26 - - - - 0.00002828 54.0
HFD2_k127_5618755_27 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.0001865 53.0
HFD2_k127_5618755_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 566.0
HFD2_k127_5618755_4 MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 563.0
HFD2_k127_5618755_5 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 542.0
HFD2_k127_5618755_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 538.0
HFD2_k127_5618755_7 O-methyltransferase activity - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 529.0
HFD2_k127_5618755_8 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004813 413.0
HFD2_k127_5618755_9 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 371.0
HFD2_k127_5639439_0 Dehydrogenase E1 component K11381 - 1.2.4.4 2.295e-315 978.0
HFD2_k127_5639439_1 ERAP1-like C-terminal domain K01263 - 3.4.11.14 4.501e-235 760.0
HFD2_k127_5639439_10 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000002244 162.0
HFD2_k127_5639439_11 Histidine kinase - - - 0.000000000000000000000000000001629 138.0
HFD2_k127_5639439_12 PFAM response regulator receiver K07657 - - 0.00000000000000000000000001358 126.0
HFD2_k127_5639439_13 Histidine kinase - - - 0.000000000000000000000000331 111.0
HFD2_k127_5639439_14 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000001579 82.0
HFD2_k127_5639439_15 PspC domain protein K03973 - - 0.00000000000007947 79.0
HFD2_k127_5639439_16 L,D-transpeptidase catalytic domain - - - 0.000000002417 68.0
HFD2_k127_5639439_17 LTXXQ motif family protein - - - 0.0001013 51.0
HFD2_k127_5639439_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001621 276.0
HFD2_k127_5639439_3 Peptidase M15 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004033 269.0
HFD2_k127_5639439_4 PFAM EAL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007017 240.0
HFD2_k127_5639439_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000001274 216.0
HFD2_k127_5639439_6 Transposase (IS116 IS110 IS902 family) - - - 0.00000000000000000000000000000000000000000000000000000009572 213.0
HFD2_k127_5639439_7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000003944 194.0
HFD2_k127_5639439_8 Transposase (IS116 IS110 IS902 family) - - - 0.000000000000000000000000000000000000000000000007177 178.0
HFD2_k127_5639439_9 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000001518 159.0
HFD2_k127_5688797_0 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 3.761e-282 897.0
HFD2_k127_5688797_1 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 500.0
HFD2_k127_5688797_10 TIGRFAM toxin-antitoxin system, toxin component, Txe YoeB family K19158 - - 0.000000000000000000000000000000000001855 139.0
HFD2_k127_5688797_11 YCII-related domain - - - 0.0000000000000000000000000744 115.0
HFD2_k127_5688797_12 Antitoxin component of a toxin-antitoxin (TA) module K19159 - - 0.0000000000000000008978 89.0
HFD2_k127_5688797_13 - - - - 0.00000000000000002468 90.0
HFD2_k127_5688797_14 - - - - 0.000002716 59.0
HFD2_k127_5688797_15 oxidoreductase activity - - - 0.00002696 56.0
HFD2_k127_5688797_16 PFAM PEGA domain - - - 0.00002978 52.0
HFD2_k127_5688797_2 Involved in the tonB-independent uptake of proteins K01256,K03641 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 509.0
HFD2_k127_5688797_3 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 397.0
HFD2_k127_5688797_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005962 276.0
HFD2_k127_5688797_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000001332 237.0
HFD2_k127_5688797_6 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000004331 216.0
HFD2_k127_5688797_7 - - - - 0.00000000000000000000000000000000000000000000000000000000001289 219.0
HFD2_k127_5688797_8 imidazolonepropionase activity - - - 0.000000000000000000000000000000000000000000000000000002848 197.0
HFD2_k127_5688797_9 EVE domain - - - 0.000000000000000000000000000000000000000559 152.0
HFD2_k127_5705256_0 AcrB/AcrD/AcrF family - - - 0.0 1117.0
HFD2_k127_5705256_1 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 0.0 1078.0
HFD2_k127_5705256_10 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008648 583.0
HFD2_k127_5705256_11 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 497.0
HFD2_k127_5705256_12 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 467.0
HFD2_k127_5705256_13 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 461.0
HFD2_k127_5705256_14 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 450.0
HFD2_k127_5705256_15 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 404.0
HFD2_k127_5705256_16 carbon starvation protein CstA K06200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 411.0
HFD2_k127_5705256_17 ABC transporter K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 366.0
HFD2_k127_5705256_18 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 339.0
HFD2_k127_5705256_19 ABC-2 family transporter protein K19341 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 319.0
HFD2_k127_5705256_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 4.427e-307 952.0
HFD2_k127_5705256_20 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 304.0
HFD2_k127_5705256_21 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008753 282.0
HFD2_k127_5705256_22 Cytochrome c K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001119 283.0
HFD2_k127_5705256_23 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000001088 269.0
HFD2_k127_5705256_24 Cytochrome c K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006822 275.0
HFD2_k127_5705256_25 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001317 274.0
HFD2_k127_5705256_26 Helix-hairpin-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006016 262.0
HFD2_k127_5705256_27 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000003059 211.0
HFD2_k127_5705256_28 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000009594 220.0
HFD2_k127_5705256_29 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000005266 165.0
HFD2_k127_5705256_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 5.628e-289 910.0
HFD2_k127_5705256_30 - - - - 0.000000000000000000000000000000000000001616 154.0
HFD2_k127_5705256_31 Di-iron-containing protein involved in the repair of iron-sulfur clusters - - - 0.000000000000000000000000000000000000007701 165.0
HFD2_k127_5705256_32 Histidine kinase - - - 0.00000000000000000000000000000000000002107 161.0
HFD2_k127_5705256_33 Cyclic nucleotide-monophosphate binding domain K21564 - - 0.000000000000000000000000000000000004841 146.0
HFD2_k127_5705256_35 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000205 150.0
HFD2_k127_5705256_36 - - - - 0.0000000000000000000000000000000005513 134.0
HFD2_k127_5705256_37 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000000000007568 146.0
HFD2_k127_5705256_38 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.0000000000000000000000000000005217 127.0
HFD2_k127_5705256_39 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000001879 113.0
HFD2_k127_5705256_4 Belongs to the peptidase S16 family - - - 2.754e-259 825.0
HFD2_k127_5705256_40 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000001314 109.0
HFD2_k127_5705256_41 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000003155 106.0
HFD2_k127_5705256_42 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000001389 102.0
HFD2_k127_5705256_43 - - - - 0.0000000000000000004018 102.0
HFD2_k127_5705256_44 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000005288 91.0
HFD2_k127_5705256_45 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000003529 94.0
HFD2_k127_5705256_46 - - - - 0.000000000000005233 86.0
HFD2_k127_5705256_47 Sulfurtransferase - - - 0.000000000000008523 87.0
HFD2_k127_5705256_48 hyperosmotic response - - - 0.00000000000001807 87.0
HFD2_k127_5705256_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 5.365e-234 750.0
HFD2_k127_5705256_50 Outer membrane efflux protein - - - 0.00000004216 65.0
HFD2_k127_5705256_51 helix_turn_helix, Lux Regulon - - - 0.00000007945 63.0
HFD2_k127_5705256_53 Helix-turn-helix domain - - - 0.00001732 52.0
HFD2_k127_5705256_6 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 8.889e-231 720.0
HFD2_k127_5705256_7 Cytochrome c - - - 1.784e-195 617.0
HFD2_k127_5705256_8 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 610.0
HFD2_k127_5705256_9 Periplasmic copper-binding protein (NosD) K07218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 596.0
HFD2_k127_5787079_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1022.0
HFD2_k127_5787079_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.121e-214 694.0
HFD2_k127_5787079_10 Cytochrome C assembly protein K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007528 455.0
HFD2_k127_5787079_11 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 446.0
HFD2_k127_5787079_12 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 413.0
HFD2_k127_5787079_13 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 411.0
HFD2_k127_5787079_14 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00322 - 1.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 418.0
HFD2_k127_5787079_15 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 399.0
HFD2_k127_5787079_16 PFAM glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 375.0
HFD2_k127_5787079_17 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249 - 1.3.8.1,1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 397.0
HFD2_k127_5787079_18 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 370.0
HFD2_k127_5787079_19 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009649 372.0
HFD2_k127_5787079_2 Cytochrome c - - - 4.213e-199 641.0
HFD2_k127_5787079_20 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 357.0
HFD2_k127_5787079_21 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 351.0
HFD2_k127_5787079_22 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 331.0
HFD2_k127_5787079_23 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 335.0
HFD2_k127_5787079_24 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 341.0
HFD2_k127_5787079_25 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 320.0
HFD2_k127_5787079_26 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 322.0
HFD2_k127_5787079_27 Trehalose utilisation K09992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 322.0
HFD2_k127_5787079_28 Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006431 290.0
HFD2_k127_5787079_29 ABC transporter, ATP-binding protein K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005445 278.0
HFD2_k127_5787079_3 Belongs to the phosphoenolpyruvate carboxykinase (ATP) family K01610 - 4.1.1.49 4.947e-194 617.0
HFD2_k127_5787079_30 Phosphate sensor histidine kinase, HAMP and PAS domain-containing K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000007596 261.0
HFD2_k127_5787079_31 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000009992 235.0
HFD2_k127_5787079_32 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000005864 250.0
HFD2_k127_5787079_33 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000009538 223.0
HFD2_k127_5787079_34 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000005065 230.0
HFD2_k127_5787079_35 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.000000000000000000000000000000000000000000000000000000000005609 218.0
HFD2_k127_5787079_36 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000007851 213.0
HFD2_k127_5787079_37 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000002869 218.0
HFD2_k127_5787079_38 Response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000000000000000000000000000000003048 205.0
HFD2_k127_5787079_39 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000006818 198.0
HFD2_k127_5787079_4 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 590.0
HFD2_k127_5787079_40 Beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000001191 201.0
HFD2_k127_5787079_41 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.00000000000000000000000000000000000000000000000002181 197.0
HFD2_k127_5787079_42 Protein of unknown function DUF47 K02039,K07220 - - 0.0000000000000000000000000000000000000000000000002195 183.0
HFD2_k127_5787079_43 Heme copper-type cytochrome quinol oxidase, subunit K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000002212 175.0
HFD2_k127_5787079_44 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000001576 181.0
HFD2_k127_5787079_45 Cytochrome oxidase assembly protein K02259 - - 0.000000000000000000000000000000000000000000008759 177.0
HFD2_k127_5787079_46 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000001033 169.0
HFD2_k127_5787079_47 PFAM ABC transporter related K02193 - 3.6.3.41 0.000000000000000000000000000000000000003862 160.0
HFD2_k127_5787079_48 Protein of unknown function, DUF547 - - - 0.00000000000000000000000000000000001777 145.0
HFD2_k127_5787079_49 CcmB protein K02194 - - 0.00000000000000000000000000000000006515 143.0
HFD2_k127_5787079_5 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 546.0
HFD2_k127_5787079_50 membrane K07152,K08976 - - 0.00000000000000000000000000000000008995 147.0
HFD2_k127_5787079_51 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000008876 145.0
HFD2_k127_5787079_52 cheY-homologous receiver domain - - - 0.00000000000000000000000000000001793 131.0
HFD2_k127_5787079_53 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000007655 137.0
HFD2_k127_5787079_54 Binding-protein-dependent transport system inner membrane component K02038 - - 0.0000000000000000000000000000008348 124.0
HFD2_k127_5787079_55 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000002472 109.0
HFD2_k127_5787079_56 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000236 109.0
HFD2_k127_5787079_57 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000001506 70.0
HFD2_k127_5787079_58 Pyruvate phosphate dikinase - - - 0.000001781 58.0
HFD2_k127_5787079_59 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000002466 57.0
HFD2_k127_5787079_6 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008928 533.0
HFD2_k127_5787079_60 - - - - 0.00002989 55.0
HFD2_k127_5787079_61 - - - - 0.0008371 48.0
HFD2_k127_5787079_7 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 470.0
HFD2_k127_5787079_8 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 461.0
HFD2_k127_5787079_9 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 452.0
HFD2_k127_593417_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 5.14e-255 805.0
HFD2_k127_593417_1 4Fe-4S single cluster domain K06937 - - 3.089e-242 769.0
HFD2_k127_593417_10 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 459.0
HFD2_k127_593417_11 Organic Anion Transporter Polypeptide (OATP) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 430.0
HFD2_k127_593417_12 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 432.0
HFD2_k127_593417_13 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 327.0
HFD2_k127_593417_14 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 309.0
HFD2_k127_593417_15 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 310.0
HFD2_k127_593417_16 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002023 286.0
HFD2_k127_593417_17 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001644 284.0
HFD2_k127_593417_18 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004454 276.0
HFD2_k127_593417_19 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004831 278.0
HFD2_k127_593417_2 GTP-binding protein TypA K06207 - - 1.173e-206 662.0
HFD2_k127_593417_20 PFAM ABC transporter K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003203 269.0
HFD2_k127_593417_21 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008536 275.0
HFD2_k127_593417_22 ATPases associated with a variety of cellular activities K01990,K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000004204 251.0
HFD2_k127_593417_23 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000008877 254.0
HFD2_k127_593417_24 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000002403 234.0
HFD2_k127_593417_25 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000003893 248.0
HFD2_k127_593417_26 PFAM Binding-protein-dependent transport system inner membrane component K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000004383 237.0
HFD2_k127_593417_27 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000004882 190.0
HFD2_k127_593417_28 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000000005382 193.0
HFD2_k127_593417_29 PFAM ABC-2 type transporter K01992,K09690 - - 0.0000000000000000000000000000000000000000006186 170.0
HFD2_k127_593417_3 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 619.0
HFD2_k127_593417_30 - - - - 0.000000000000000000000000000000000000001684 166.0
HFD2_k127_593417_31 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000695 152.0
HFD2_k127_593417_32 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000009433 157.0
HFD2_k127_593417_33 Methyltransferase domain - - - 0.0000000000000000000000000000000002958 141.0
HFD2_k127_593417_34 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000003024 141.0
HFD2_k127_593417_35 ubiquitin K02927,K20276 - - 0.0000000000000000000000000000001233 144.0
HFD2_k127_593417_36 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 0.0000000000000000000000000000002692 129.0
HFD2_k127_593417_37 Methyltransferase domain - - - 0.0000000000000000000000000001325 132.0
HFD2_k127_593417_38 membrane - - - 0.0000000000000000000000000007896 119.0
HFD2_k127_593417_39 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000001122 116.0
HFD2_k127_593417_4 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 586.0
HFD2_k127_593417_40 endo-1,4-beta-xylanase activity - - - 0.00000000000000000000006033 111.0
HFD2_k127_593417_41 Smr domain - - - 0.0000000000000000000001256 99.0
HFD2_k127_593417_42 diguanylate cyclase - - - 0.0000000000000000000007395 109.0
HFD2_k127_593417_43 acetyltransferase - GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.0000000000000000000009853 101.0
HFD2_k127_593417_44 PFAM translation initiation factor SUI1 K03113 - - 0.000000000000000000005024 99.0
HFD2_k127_593417_45 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000002735 94.0
HFD2_k127_593417_46 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000001623 97.0
HFD2_k127_593417_47 PFAM Anti-sigma-K factor RskA - - - 0.0000000000000001776 89.0
HFD2_k127_593417_48 Transcriptional regulatory protein, C terminal - - - 0.0000000000000004903 89.0
HFD2_k127_593417_49 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000009673 83.0
HFD2_k127_593417_5 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 544.0
HFD2_k127_593417_50 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000001163 77.0
HFD2_k127_593417_51 DsrE/DsrF-like family - - - 0.000000000002034 71.0
HFD2_k127_593417_52 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000004079 75.0
HFD2_k127_593417_53 LysM domain - - - 0.000000000009322 76.0
HFD2_k127_593417_54 polysaccharide deacetylase - - - 0.00000000002236 78.0
HFD2_k127_593417_55 mttA/Hcf106 family K03116 - - 0.00000000002985 66.0
HFD2_k127_593417_56 redox protein, regulator of disulfide bond formation - - - 0.0000000006067 67.0
HFD2_k127_593417_57 Domain of unknown function (DUF4331) - - - 0.0000000008426 60.0
HFD2_k127_593417_58 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000001308 59.0
HFD2_k127_593417_59 - - - - 0.0000001945 58.0
HFD2_k127_593417_6 Putative zinc-binding metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007225 522.0
HFD2_k127_593417_60 PFAM helix-turn-helix, Fis-type - - - 0.00003223 51.0
HFD2_k127_593417_61 Belongs to the peptidase S8 family - - - 0.0001897 54.0
HFD2_k127_593417_7 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 482.0
HFD2_k127_593417_8 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 475.0
HFD2_k127_593417_9 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 495.0
HFD2_k127_5943108_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1588.0
HFD2_k127_5943108_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1441.0
HFD2_k127_5943108_2 RND efflux system, outer membrane lipoprotein, NodT - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 459.0
HFD2_k127_5943108_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008716 434.0
HFD2_k127_5943108_4 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000001482 243.0
HFD2_k127_5943108_5 serine-type endopeptidase activity K08372 - - 0.0000000000000000000000000000000000000000000000000000000000000002022 235.0
HFD2_k127_5956401_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1296.0
HFD2_k127_5956401_1 Dihydroxyacetone kinase family K07030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 437.0
HFD2_k127_5956401_10 lipase activity K15349 - - 0.000000000000000000000000000000009929 146.0
HFD2_k127_5956401_11 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000000000000000000000003295 141.0
HFD2_k127_5956401_12 Peptidase family M23 K21472 - - 0.0000000000000000000000000000128 130.0
HFD2_k127_5956401_13 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000008669 121.0
HFD2_k127_5956401_14 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000001579 131.0
HFD2_k127_5956401_15 Diguanylate cyclase - - - 0.000000000000000000000000002421 125.0
HFD2_k127_5956401_16 UPF0761 membrane protein K07058 - - 0.000000000000003285 89.0
HFD2_k127_5956401_17 - - - - 0.00000000001688 68.0
HFD2_k127_5956401_18 Domain of unknown function (DUF4410) - - - 0.00000000008648 71.0
HFD2_k127_5956401_19 Belongs to the UPF0337 (CsbD) family - - - 0.00009515 50.0
HFD2_k127_5956401_2 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 309.0
HFD2_k127_5956401_3 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 304.0
HFD2_k127_5956401_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000001562 214.0
HFD2_k127_5956401_5 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000004166 206.0
HFD2_k127_5956401_6 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000005826 192.0
HFD2_k127_5956401_7 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.00000000000000000000000000000000000000000000000002182 196.0
HFD2_k127_5956401_8 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000008144 169.0
HFD2_k127_5956401_9 glycine decarboxylation via glycine cleavage system K02437 - - 0.0000000000000000000000000000000000000000004093 161.0
HFD2_k127_6144145_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1373.0
HFD2_k127_6144145_1 efflux transmembrane transporter activity - - - 1.148e-279 884.0
HFD2_k127_6144145_10 Ferric uptake regulator family K09825 - - 0.0000000000000000000000000001886 119.0
HFD2_k127_6144145_11 Protein of unknown function (DUF3313) - - - 0.000000000000000000000002117 109.0
HFD2_k127_6144145_12 Type IV pilus biogenesis stability protein PilW - - - 0.00000000002944 69.0
HFD2_k127_6144145_13 Pfam Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000002311 61.0
HFD2_k127_6144145_14 - - - - 0.0001392 50.0
HFD2_k127_6144145_2 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 429.0
HFD2_k127_6144145_3 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005834 319.0
HFD2_k127_6144145_4 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000176 260.0
HFD2_k127_6144145_5 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002015 265.0
HFD2_k127_6144145_6 DinB family - - - 0.0000000000000000000000000000000000000000000000000000005314 199.0
HFD2_k127_6144145_7 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000005452 193.0
HFD2_k127_6144145_8 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000000000000000000000000000000000101 182.0
HFD2_k127_6144145_9 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000614 160.0
HFD2_k127_615396_0 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 599.0
HFD2_k127_615396_1 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 402.0
HFD2_k127_615396_10 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000001032 139.0
HFD2_k127_615396_11 Rhodanese domain protein - - - 0.00000001747 56.0
HFD2_k127_615396_12 SNARE associated Golgi protein - - - 0.000000061 58.0
HFD2_k127_615396_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 352.0
HFD2_k127_615396_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 304.0
HFD2_k127_615396_4 surface antigen variable number - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009804 287.0
HFD2_k127_615396_5 PFAM Transposase IS200 like - - - 0.00000000000000000000000000000000000000000000000000000000000000000008288 243.0
HFD2_k127_615396_6 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) K06169 - - 0.000000000000000000000000000000000000000000000000000000000000000001282 233.0
HFD2_k127_615396_7 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000006613 213.0
HFD2_k127_615396_8 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000007183 198.0
HFD2_k127_615396_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000002211 137.0
HFD2_k127_617260_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1388.0
HFD2_k127_617260_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 3.56e-322 1004.0
HFD2_k127_617260_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 1.559e-270 843.0
HFD2_k127_617260_3 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 1.119e-244 766.0
HFD2_k127_6182484_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.327e-237 757.0
HFD2_k127_6182484_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.711e-220 715.0
HFD2_k127_6182484_10 Protein of unknown function (DUF503) K09764 - - 0.00000000000003965 76.0
HFD2_k127_6182484_11 BON domain - - - 0.0000000000005054 79.0
HFD2_k127_6182484_12 energy transducer activity K03832 - - 0.0000003261 62.0
HFD2_k127_6182484_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 473.0
HFD2_k127_6182484_3 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 376.0
HFD2_k127_6182484_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 357.0
HFD2_k127_6182484_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000178 203.0
HFD2_k127_6182484_6 CoA-binding protein K06929 - - 0.000000000000000000000000000000007067 137.0
HFD2_k127_6182484_7 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000005692 123.0
HFD2_k127_6182484_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000001339 95.0
HFD2_k127_6182484_9 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000007006 96.0
HFD2_k127_6242336_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 4.375e-272 859.0
HFD2_k127_6242336_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.081e-237 755.0
HFD2_k127_6242336_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 338.0
HFD2_k127_6242336_11 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 327.0
HFD2_k127_6242336_12 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 342.0
HFD2_k127_6242336_13 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 325.0
HFD2_k127_6242336_14 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 295.0
HFD2_k127_6242336_15 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 296.0
HFD2_k127_6242336_16 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002155 293.0
HFD2_k127_6242336_17 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001236 266.0
HFD2_k127_6242336_18 ASPIC and UnbV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001849 265.0
HFD2_k127_6242336_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001308 247.0
HFD2_k127_6242336_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 578.0
HFD2_k127_6242336_20 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000122 226.0
HFD2_k127_6242336_21 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000001779 196.0
HFD2_k127_6242336_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.00000000000000000000000000000000000000002349 160.0
HFD2_k127_6242336_23 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000001595 164.0
HFD2_k127_6242336_24 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000002005 154.0
HFD2_k127_6242336_25 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571,K01960 - 4.1.1.3,6.4.1.1 0.00000000000000000000000000000000003316 140.0
HFD2_k127_6242336_26 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K09007,K13940,K17488 - 2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25 0.0000000000000000000000000000000284 135.0
HFD2_k127_6242336_27 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.0000000000000000000000000000001503 126.0
HFD2_k127_6242336_28 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000002755 130.0
HFD2_k127_6242336_29 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000102 136.0
HFD2_k127_6242336_3 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 558.0
HFD2_k127_6242336_30 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000009851 121.0
HFD2_k127_6242336_31 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000004129 128.0
HFD2_k127_6242336_32 Preprotein translocase subunit YajC K03210 - - 0.0000000000000000003589 97.0
HFD2_k127_6242336_33 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000002303 86.0
HFD2_k127_6242336_34 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000000373 82.0
HFD2_k127_6242336_35 Protein of unknown function (FYDLN_acid) - - - 0.0000000000008904 72.0
HFD2_k127_6242336_36 Polymer-forming cytoskeletal - - - 0.000000008964 67.0
HFD2_k127_6242336_38 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000003681 56.0
HFD2_k127_6242336_39 Tetratricopeptide repeat - - - 0.00000003759 64.0
HFD2_k127_6242336_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 550.0
HFD2_k127_6242336_40 Tetratricopeptide repeat - - - 0.0000005668 61.0
HFD2_k127_6242336_41 Two component regulator propeller - - - 0.000002122 61.0
HFD2_k127_6242336_42 Domain of unknown function DUF11 - - - 0.0003081 54.0
HFD2_k127_6242336_43 chaperone-mediated protein folding - - - 0.0003521 53.0
HFD2_k127_6242336_5 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 466.0
HFD2_k127_6242336_6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 444.0
HFD2_k127_6242336_7 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 376.0
HFD2_k127_6242336_8 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 369.0
HFD2_k127_6242336_9 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 339.0
HFD2_k127_6270471_0 Tricorn protease homolog - - - 0.0 1489.0
HFD2_k127_6270471_1 Phosphoesterase family - - - 7.946e-211 689.0
HFD2_k127_6270471_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000001596 229.0
HFD2_k127_6270471_11 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000000000000000000001273 140.0
HFD2_k127_6270471_12 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.00000000000000000000000000000000002762 139.0
HFD2_k127_6270471_13 diguanylate cyclase - - - 0.0000000000000000000000000000000003907 148.0
HFD2_k127_6270471_14 methylamine metabolic process - - - 0.000000000000000000000000000005438 135.0
HFD2_k127_6270471_15 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01760 - 4.4.1.8 0.00000000000000000000000000007888 123.0
HFD2_k127_6270471_16 collagen metabolic process - - - 0.00000000000004154 82.0
HFD2_k127_6270471_17 - - - - 0.000000004458 62.0
HFD2_k127_6270471_2 Insulinase (Peptidase family M16) K07263 - - 2.026e-198 633.0
HFD2_k127_6270471_3 enterobactin catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 560.0
HFD2_k127_6270471_4 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 491.0
HFD2_k127_6270471_5 acid phosphatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 361.0
HFD2_k127_6270471_6 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 355.0
HFD2_k127_6270471_7 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009458 286.0
HFD2_k127_6270471_8 Peptidase family S51 K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003304 277.0
HFD2_k127_6270471_9 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000002227 249.0
HFD2_k127_6330933_0 Involved in the tonB-independent uptake of proteins - - - 2.55e-206 670.0
HFD2_k127_6330933_1 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000006974 136.0
HFD2_k127_6330933_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000006347 86.0
HFD2_k127_6404769_0 Sortilin, neurotensin receptor 3, - - - 0.0 1166.0
HFD2_k127_6404769_1 DNA polymerase III alpha subunit K02337 - 2.7.7.7 1.438e-314 1000.0
HFD2_k127_6404769_10 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 547.0
HFD2_k127_6404769_100 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000001413 234.0
HFD2_k127_6404769_101 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000001652 232.0
HFD2_k127_6404769_102 NAD(P)H-binding K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000001642 225.0
HFD2_k127_6404769_103 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000003352 227.0
HFD2_k127_6404769_104 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000005785 226.0
HFD2_k127_6404769_105 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000001642 227.0
HFD2_k127_6404769_106 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000218 226.0
HFD2_k127_6404769_107 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000003416 231.0
HFD2_k127_6404769_108 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000553 219.0
HFD2_k127_6404769_109 Histidine biosynthesis bifunctional protein hisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000001141 221.0
HFD2_k127_6404769_11 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 543.0
HFD2_k127_6404769_110 lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000006372 213.0
HFD2_k127_6404769_111 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000003687 198.0
HFD2_k127_6404769_112 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000006666 203.0
HFD2_k127_6404769_113 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000001226 198.0
HFD2_k127_6404769_114 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000001075 201.0
HFD2_k127_6404769_115 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000005402 205.0
HFD2_k127_6404769_116 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000001137 203.0
HFD2_k127_6404769_117 SMART CBS domain containing protein K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000001092 199.0
HFD2_k127_6404769_118 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.000000000000000000000000000000000000000000000000001135 203.0
HFD2_k127_6404769_119 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000002462 193.0
HFD2_k127_6404769_12 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 522.0
HFD2_k127_6404769_120 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000131 188.0
HFD2_k127_6404769_121 PFAM Peptidase S66, LD-carboxypeptidase A K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000002661 191.0
HFD2_k127_6404769_122 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000003243 190.0
HFD2_k127_6404769_123 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000001044 188.0
HFD2_k127_6404769_124 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000005835 173.0
HFD2_k127_6404769_125 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000007658 173.0
HFD2_k127_6404769_126 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000002285 185.0
HFD2_k127_6404769_127 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000002949 192.0
HFD2_k127_6404769_128 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000004299 173.0
HFD2_k127_6404769_129 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000005492 171.0
HFD2_k127_6404769_13 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 521.0
HFD2_k127_6404769_130 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000002621 168.0
HFD2_k127_6404769_131 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372,K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000001704 179.0
HFD2_k127_6404769_132 Peptidase family M50 K06402 - - 0.0000000000000000000000000000000000000000002515 167.0
HFD2_k127_6404769_133 aminopeptidase activity K07004 - - 0.0000000000000000000000000000000000000000003389 181.0
HFD2_k127_6404769_134 TIGR00255 family - - - 0.0000000000000000000000000000000000000000004269 182.0
HFD2_k127_6404769_135 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000005147 172.0
HFD2_k127_6404769_136 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000005155 166.0
HFD2_k127_6404769_137 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000005369 161.0
HFD2_k127_6404769_138 - K07018 - - 0.0000000000000000000000000000000000000000008846 167.0
HFD2_k127_6404769_139 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000002669 165.0
HFD2_k127_6404769_14 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 532.0
HFD2_k127_6404769_140 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000000000000002761 181.0
HFD2_k127_6404769_141 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000003437 162.0
HFD2_k127_6404769_142 Histidine kinase - - - 0.000000000000000000000000000000000000000005579 169.0
HFD2_k127_6404769_143 3-dehydroquinate dehydratase activity K00014,K03785,K13832 GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0042537,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.1.25,4.2.1.10 0.00000000000000000000000000000000000000002088 171.0
HFD2_k127_6404769_144 PAP2 superfamily - - - 0.00000000000000000000000000000000000000002394 165.0
HFD2_k127_6404769_145 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000001175 157.0
HFD2_k127_6404769_146 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000002075 153.0
HFD2_k127_6404769_147 NmrA-like family - - - 0.000000000000000000000000000000000000000209 164.0
HFD2_k127_6404769_148 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000009296 157.0
HFD2_k127_6404769_149 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000001598 163.0
HFD2_k127_6404769_15 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 514.0
HFD2_k127_6404769_150 NUDIX domain - - - 0.000000000000000000000000000000000000002507 153.0
HFD2_k127_6404769_151 OmpA family K03640 - - 0.000000000000000000000000000000000000004016 153.0
HFD2_k127_6404769_152 Belongs to the TrpC family K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000005043 166.0
HFD2_k127_6404769_153 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000007699 155.0
HFD2_k127_6404769_154 Thioredoxin K03671 - - 0.00000000000000000000000000000000000001977 147.0
HFD2_k127_6404769_155 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000009485 152.0
HFD2_k127_6404769_156 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000006772 151.0
HFD2_k127_6404769_157 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000003331 145.0
HFD2_k127_6404769_158 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000002847 154.0
HFD2_k127_6404769_159 histone H2A K63-linked ubiquitination K10914 - - 0.0000000000000000000000000000000004361 149.0
HFD2_k127_6404769_16 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 516.0
HFD2_k127_6404769_160 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000004624 148.0
HFD2_k127_6404769_161 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.00000000000000000000000000000000503 141.0
HFD2_k127_6404769_162 Tetratricopeptide repeat - - - 0.00000000000000000000000000000001836 146.0
HFD2_k127_6404769_163 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000003459 136.0
HFD2_k127_6404769_164 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000005663 132.0
HFD2_k127_6404769_165 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000001338 140.0
HFD2_k127_6404769_166 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000000000001413 125.0
HFD2_k127_6404769_167 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000002849 130.0
HFD2_k127_6404769_168 PFAM thioesterase superfamily K07107 - - 0.0000000000000000000000000000008398 136.0
HFD2_k127_6404769_169 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000009296 128.0
HFD2_k127_6404769_17 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000893 484.0
HFD2_k127_6404769_170 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000009378 137.0
HFD2_k127_6404769_171 Transglycosylase SLT domain - - - 0.000000000000000000000000000001651 137.0
HFD2_k127_6404769_172 Could be involved in septation K06412 - - 0.000000000000000000000000000002417 125.0
HFD2_k127_6404769_173 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000126 128.0
HFD2_k127_6404769_174 domain, Protein - - - 0.00000000000000000000000000004977 135.0
HFD2_k127_6404769_175 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000002439 130.0
HFD2_k127_6404769_176 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000004894 127.0
HFD2_k127_6404769_177 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000006376 115.0
HFD2_k127_6404769_178 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000165 117.0
HFD2_k127_6404769_179 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.000000000000000000000000007606 115.0
HFD2_k127_6404769_18 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 488.0
HFD2_k127_6404769_180 phosphorelay signal transduction system - - - 0.00000000000000000000000003997 124.0
HFD2_k127_6404769_181 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000004342 115.0
HFD2_k127_6404769_182 Belongs to the GcvT family K06980 - - 0.00000000000000000000000006007 119.0
HFD2_k127_6404769_183 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000006841 110.0
HFD2_k127_6404769_184 - - - - 0.0000000000000000000000007426 117.0
HFD2_k127_6404769_185 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000208 111.0
HFD2_k127_6404769_186 YXWGXW repeat (2 copies) - - - 0.000000000000000000000002282 105.0
HFD2_k127_6404769_187 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000002176 113.0
HFD2_k127_6404769_188 Phosphotransferase System K11189 - - 0.000000000000000000001091 102.0
HFD2_k127_6404769_189 Domain of unknown function (DUF4115) - - - 0.000000000000000000004267 103.0
HFD2_k127_6404769_19 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 484.0
HFD2_k127_6404769_190 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.00000000000000000002836 98.0
HFD2_k127_6404769_191 Cation efflux family - - - 0.00000000000000000002939 100.0
HFD2_k127_6404769_192 thiolester hydrolase activity K17362 - - 0.00000000000000000003745 98.0
HFD2_k127_6404769_193 CHRD domain - - - 0.00000000000000000005723 103.0
HFD2_k127_6404769_194 - - - - 0.00000000000000000007699 102.0
HFD2_k127_6404769_195 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000004899 93.0
HFD2_k127_6404769_196 Putative Fe-S cluster K00380 - 1.8.1.2 0.0000000000000000005039 95.0
HFD2_k127_6404769_197 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000006827 94.0
HFD2_k127_6404769_198 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000008627 98.0
HFD2_k127_6404769_199 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000001568 97.0
HFD2_k127_6404769_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.028e-286 903.0
HFD2_k127_6404769_20 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 486.0
HFD2_k127_6404769_200 tetratricopeptide repeat - - - 0.00000000000000001637 98.0
HFD2_k127_6404769_201 TonB C terminal K03646,K03832 - - 0.00000000000000006198 90.0
HFD2_k127_6404769_202 COG1214 Inactive homolog of metal-dependent proteases K01409,K14742 - 2.3.1.234 0.0000000000000001574 87.0
HFD2_k127_6404769_203 - - - - 0.000000000000002098 90.0
HFD2_k127_6404769_205 lipopolysaccharide transport K09774 - - 0.0000000000001214 85.0
HFD2_k127_6404769_206 - - - - 0.000000000005745 76.0
HFD2_k127_6404769_208 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000003318 69.0
HFD2_k127_6404769_209 Predicted membrane protein (DUF2232) - - - 0.0000000003592 71.0
HFD2_k127_6404769_21 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000087 467.0
HFD2_k127_6404769_210 type II secretion system protein E K02652 - - 0.00000000697 68.0
HFD2_k127_6404769_211 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000001239 64.0
HFD2_k127_6404769_212 Binds directly to 16S ribosomal RNA K02968 - - 0.00000002929 58.0
HFD2_k127_6404769_213 Transglutaminase-like superfamily - - - 0.00000003757 65.0
HFD2_k127_6404769_214 Domain of unknown function (DUF4126) - - - 0.0000001476 64.0
HFD2_k127_6404769_215 type II secretion system protein E K02652 - - 0.000000211 63.0
HFD2_k127_6404769_216 polyketide synthase - - - 0.0000004791 62.0
HFD2_k127_6404769_217 outer membrane chaperone Skp (OmpH) K06142 - - 0.00000224 58.0
HFD2_k127_6404769_218 heat shock protein binding - - - 0.000004313 60.0
HFD2_k127_6404769_219 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00001219 52.0
HFD2_k127_6404769_22 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 455.0
HFD2_k127_6404769_220 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.00001422 59.0
HFD2_k127_6404769_221 Belongs to the peptidase S16 family K01338 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0006508,GO:0006605,GO:0006625,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0016043,GO:0016485,GO:0019538,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044238,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564 3.4.21.53 0.00008724 55.0
HFD2_k127_6404769_222 protein conserved in bacteria K03749 - - 0.0001551 51.0
HFD2_k127_6404769_223 Domain of unknown function (DUF4149) - - - 0.0001698 50.0
HFD2_k127_6404769_224 histidine kinase A domain protein K02484,K07642 - 2.7.13.3 0.0001956 54.0
HFD2_k127_6404769_225 deoxyhypusine monooxygenase activity - - - 0.0005405 52.0
HFD2_k127_6404769_23 Belongs to the thiolase family K00626,K07508 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 443.0
HFD2_k127_6404769_24 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 439.0
HFD2_k127_6404769_25 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 433.0
HFD2_k127_6404769_26 Cys/Met metabolism PLP-dependent enzyme K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 465.0
HFD2_k127_6404769_27 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 433.0
HFD2_k127_6404769_28 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 414.0
HFD2_k127_6404769_29 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 424.0
HFD2_k127_6404769_3 Belongs to the ClpA ClpB family K03696 - - 2.172e-284 895.0
HFD2_k127_6404769_30 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 420.0
HFD2_k127_6404769_31 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008635 404.0
HFD2_k127_6404769_32 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 413.0
HFD2_k127_6404769_33 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 402.0
HFD2_k127_6404769_34 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 394.0
HFD2_k127_6404769_35 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 382.0
HFD2_k127_6404769_36 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 383.0
HFD2_k127_6404769_37 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 374.0
HFD2_k127_6404769_38 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 375.0
HFD2_k127_6404769_39 ATP-dependent helicase activity K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 387.0
HFD2_k127_6404769_4 tRNA synthetases class I (K) K01870 - 6.1.1.5 4.285e-280 891.0
HFD2_k127_6404769_40 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007278 377.0
HFD2_k127_6404769_41 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007413 352.0
HFD2_k127_6404769_42 DegT/DnrJ/EryC1/StrS aminotransferase family K12452 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 360.0
HFD2_k127_6404769_43 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 360.0
HFD2_k127_6404769_44 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 354.0
HFD2_k127_6404769_45 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 342.0
HFD2_k127_6404769_46 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007152 340.0
HFD2_k127_6404769_47 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 336.0
HFD2_k127_6404769_48 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 348.0
HFD2_k127_6404769_49 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 338.0
HFD2_k127_6404769_5 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.488e-265 844.0
HFD2_k127_6404769_50 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 326.0
HFD2_k127_6404769_51 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 329.0
HFD2_k127_6404769_52 Peptidase M36 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 336.0
HFD2_k127_6404769_53 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 333.0
HFD2_k127_6404769_54 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 320.0
HFD2_k127_6404769_55 Permease YjgP YjgQ family protein K07091,K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 340.0
HFD2_k127_6404769_56 ABC 3 transport family K02075 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 325.0
HFD2_k127_6404769_57 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 318.0
HFD2_k127_6404769_58 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 313.0
HFD2_k127_6404769_59 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 339.0
HFD2_k127_6404769_6 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.037e-199 651.0
HFD2_k127_6404769_60 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 313.0
HFD2_k127_6404769_61 PFAM PfkB domain protein K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 313.0
HFD2_k127_6404769_62 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 308.0
HFD2_k127_6404769_63 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 321.0
HFD2_k127_6404769_64 PFAM ABC transporter related K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 297.0
HFD2_k127_6404769_65 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008516 302.0
HFD2_k127_6404769_66 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 315.0
HFD2_k127_6404769_67 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 314.0
HFD2_k127_6404769_68 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 317.0
HFD2_k127_6404769_69 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 302.0
HFD2_k127_6404769_7 Ribosomal protein S1 K02945,K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 617.0
HFD2_k127_6404769_70 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 291.0
HFD2_k127_6404769_71 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000765 300.0
HFD2_k127_6404769_72 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 299.0
HFD2_k127_6404769_73 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 290.0
HFD2_k127_6404769_74 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005473 288.0
HFD2_k127_6404769_75 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000133 285.0
HFD2_k127_6404769_76 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001113 279.0
HFD2_k127_6404769_77 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005807 289.0
HFD2_k127_6404769_78 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001411 275.0
HFD2_k127_6404769_79 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003696 282.0
HFD2_k127_6404769_8 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 586.0
HFD2_k127_6404769_80 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000004958 273.0
HFD2_k127_6404769_81 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000002151 271.0
HFD2_k127_6404769_82 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000003553 269.0
HFD2_k127_6404769_83 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000003817 270.0
HFD2_k127_6404769_84 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000004562 276.0
HFD2_k127_6404769_85 Pfam Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001158 267.0
HFD2_k127_6404769_86 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000001642 265.0
HFD2_k127_6404769_87 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000001256 243.0
HFD2_k127_6404769_88 Histidinol phosphate phosphatase, HisJ family K04486 - 3.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000006832 253.0
HFD2_k127_6404769_89 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000007177 245.0
HFD2_k127_6404769_9 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 570.0
HFD2_k127_6404769_90 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000119 250.0
HFD2_k127_6404769_91 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000242 242.0
HFD2_k127_6404769_92 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000004723 253.0
HFD2_k127_6404769_93 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001223 231.0
HFD2_k127_6404769_94 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000001366 252.0
HFD2_k127_6404769_95 SpoIVB peptidase S55 - - - 0.00000000000000000000000000000000000000000000000000000000000000008841 245.0
HFD2_k127_6404769_96 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000002115 229.0
HFD2_k127_6404769_97 Belongs to the pseudouridine synthase RsuA family K06178,K06182 - 5.4.99.21,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000433 229.0
HFD2_k127_6404769_98 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000002727 226.0
HFD2_k127_6404769_99 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000008108 238.0
HFD2_k127_6613329_0 Bacterial membrane protein YfhO - - - 0.000000000000000000003726 110.0
HFD2_k127_6613329_1 Psort location CytoplasmicMembrane, score - - - 0.0000000001269 75.0
HFD2_k127_6645521_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 5.86e-212 675.0
HFD2_k127_6645521_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 576.0
HFD2_k127_6645521_10 Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005655 256.0
HFD2_k127_6645521_11 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000003792 239.0
HFD2_k127_6645521_12 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - 0.000000000000000000000000000000000000000000000000000000000001241 225.0
HFD2_k127_6645521_13 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000006175 214.0
HFD2_k127_6645521_14 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000003632 198.0
HFD2_k127_6645521_15 ATPase activity - - - 0.00000000000000000000000000000000000000000000000009663 198.0
HFD2_k127_6645521_16 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000004496 183.0
HFD2_k127_6645521_17 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000002416 185.0
HFD2_k127_6645521_18 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000002883 136.0
HFD2_k127_6645521_19 Pfam:UPF0118 - - - 0.0000000000000000000000000000000004929 148.0
HFD2_k127_6645521_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 463.0
HFD2_k127_6645521_20 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000004956 144.0
HFD2_k127_6645521_21 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000002379 135.0
HFD2_k127_6645521_22 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.00000000000000000000000000000714 128.0
HFD2_k127_6645521_23 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000001325 102.0
HFD2_k127_6645521_24 chlorophyll binding - - - 0.0000000000000004026 91.0
HFD2_k127_6645521_25 peptidyl-tyrosine sulfation - - - 0.0000000000000338 81.0
HFD2_k127_6645521_27 SprT-like family - - - 0.00006187 52.0
HFD2_k127_6645521_3 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 356.0
HFD2_k127_6645521_4 L-carnitine dehydratase bile acid-inducible protein F K18702 - 2.8.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 342.0
HFD2_k127_6645521_5 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 313.0
HFD2_k127_6645521_6 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 318.0
HFD2_k127_6645521_7 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 324.0
HFD2_k127_6645521_8 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001193 269.0
HFD2_k127_6645521_9 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000002655 246.0
HFD2_k127_6690578_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 454.0
HFD2_k127_6690578_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 383.0
HFD2_k127_6690578_2 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 330.0
HFD2_k127_6690578_3 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001373 285.0
HFD2_k127_6690578_4 Domain of Unknown Function (DUF1259) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001218 273.0
HFD2_k127_6690578_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001566 263.0
HFD2_k127_6690578_6 cation efflux K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000001424 231.0
HFD2_k127_6690578_7 Cytochrome c - - - 0.0000000000000000000000000000000001313 137.0
HFD2_k127_6690578_8 amine dehydrogenase activity - - - 0.00001017 57.0
HFD2_k127_6892918_0 response to abiotic stimulus K03086,K06867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 543.0
HFD2_k127_6892918_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 480.0
HFD2_k127_6892918_10 oxidation-reduction process - - - 0.000000000000000000000000004436 125.0
HFD2_k127_6892918_2 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 322.0
HFD2_k127_6892918_3 ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002284 251.0
HFD2_k127_6892918_4 COG0642 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003513 255.0
HFD2_k127_6892918_5 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003677 220.0
HFD2_k127_6892918_6 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000004693 229.0
HFD2_k127_6892918_7 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000003062 185.0
HFD2_k127_6892918_8 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000003545 183.0
HFD2_k127_6892918_9 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000001964 151.0
HFD2_k127_6959947_0 metal-dependent hydrolase with the TIM-barrel fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 467.0
HFD2_k127_6959947_1 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 307.0
HFD2_k127_6959947_10 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000006947 185.0
HFD2_k127_6959947_11 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000000002143 154.0
HFD2_k127_6959947_12 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000001915 139.0
HFD2_k127_6959947_13 antisigma factor binding - - - 0.0000000000000000000000447 107.0
HFD2_k127_6959947_14 sigma factor antagonist activity K04757 - 2.7.11.1 0.00000000000000000000005155 106.0
HFD2_k127_6959947_15 methyltransferase activity K15256 - - 0.00000000000000000000005343 115.0
HFD2_k127_6959947_16 COG0470 ATPase involved in DNA replication K02341 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000001202 107.0
HFD2_k127_6959947_17 Acetyltransferase (GNAT) domain - - - 0.00000000001965 77.0
HFD2_k127_6959947_18 Glycosyl transferase family 2 K07011 - - 0.00000000001999 76.0
HFD2_k127_6959947_19 PFAM Glycosyl transferases group 1 - - - 0.000000007557 68.0
HFD2_k127_6959947_2 Sigma-54 interaction domain K02584,K07713,K15836,K21009 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001201 293.0
HFD2_k127_6959947_20 cell adhesion involved in biofilm formation K02453 - - 0.0005382 51.0
HFD2_k127_6959947_3 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001472 289.0
HFD2_k127_6959947_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000008038 269.0
HFD2_k127_6959947_5 Glycosyltransferase, group 2 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000005109 246.0
HFD2_k127_6959947_6 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000001911 237.0
HFD2_k127_6959947_7 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000005258 219.0
HFD2_k127_6959947_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000001291 194.0
HFD2_k127_6959947_9 Glycosyl transferase family group 2 K07011 - - 0.00000000000000000000000000000000000000000000001097 188.0
HFD2_k127_7014477_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1176.0
HFD2_k127_7014477_1 Involved in the tonB-independent uptake of proteins - - - 4.61e-240 769.0
HFD2_k127_7014477_10 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 469.0
HFD2_k127_7014477_11 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 452.0
HFD2_k127_7014477_12 Glutamate formiminotransferase K00603,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 361.0
HFD2_k127_7014477_13 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 377.0
HFD2_k127_7014477_14 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 345.0
HFD2_k127_7014477_15 Transposase (IS116 IS110 IS902 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 346.0
HFD2_k127_7014477_16 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 329.0
HFD2_k127_7014477_17 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 321.0
HFD2_k127_7014477_18 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 299.0
HFD2_k127_7014477_19 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 299.0
HFD2_k127_7014477_2 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.157e-236 752.0
HFD2_k127_7014477_20 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 316.0
HFD2_k127_7014477_21 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004354 265.0
HFD2_k127_7014477_22 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000002174 275.0
HFD2_k127_7014477_23 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000002101 240.0
HFD2_k127_7014477_24 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000009139 247.0
HFD2_k127_7014477_25 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000004166 221.0
HFD2_k127_7014477_26 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000001419 202.0
HFD2_k127_7014477_27 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000371 205.0
HFD2_k127_7014477_28 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000005912 207.0
HFD2_k127_7014477_29 Ku70/Ku80 beta-barrel domain - - - 0.000000000000000000000000000000000000000000000000005756 193.0
HFD2_k127_7014477_3 3-isopropylmalate dehydratase activity K01703 - 4.2.1.33,4.2.1.35 4.712e-201 635.0
HFD2_k127_7014477_30 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000008428 176.0
HFD2_k127_7014477_31 Cupin domain - - - 0.00000000000000000000000000000000000000000000001093 176.0
HFD2_k127_7014477_32 NmrA-like family - - - 0.00000000000000000000000000000000000000003306 158.0
HFD2_k127_7014477_33 - - - - 0.0000000000000000000000000000000008708 132.0
HFD2_k127_7014477_34 3-demethylubiquinone-9 3-O-methyltransferase activity K20444 - - 0.0000000000000000000000000000001014 132.0
HFD2_k127_7014477_35 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000344 117.0
HFD2_k127_7014477_36 - - - - 0.00000000000000000000000004336 125.0
HFD2_k127_7014477_37 membrane - - - 0.000000000000000000000007712 106.0
HFD2_k127_7014477_39 OmpA family - - - 0.0000000000000000000001418 112.0
HFD2_k127_7014477_4 cyclic 2,3-diphosphoglycerate synthetase activity - - - 6.716e-197 631.0
HFD2_k127_7014477_40 PFAM GCN5-related N-acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000009446 102.0
HFD2_k127_7014477_41 Peptidase family M1 domain - - - 0.00000000000000000001709 107.0
HFD2_k127_7014477_42 - - - - 0.00000000000000000169 88.0
HFD2_k127_7014477_43 Domain of unknown function (DUF2383) - - - 0.00000000000000001032 90.0
HFD2_k127_7014477_44 COG3209 Rhs family protein - - - 0.00000000000001883 87.0
HFD2_k127_7014477_45 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000001834 81.0
HFD2_k127_7014477_46 Belongs to the peptidase S8 family - - - 0.00000000003573 76.0
HFD2_k127_7014477_47 - - - - 0.000000003315 59.0
HFD2_k127_7014477_48 - - - - 0.000000007723 68.0
HFD2_k127_7014477_49 PAN domain - - - 0.00000008083 63.0
HFD2_k127_7014477_5 Beta-eliminating lyase K01667 - 4.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 583.0
HFD2_k127_7014477_50 PFAM peptidase S1 and S6, chymotrypsin Hap - - - 0.00006246 54.0
HFD2_k127_7014477_51 Protein of unknown function (DUF1328) - - - 0.0002625 53.0
HFD2_k127_7014477_6 PAS fold-4 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 605.0
HFD2_k127_7014477_7 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 547.0
HFD2_k127_7014477_8 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 528.0
HFD2_k127_7014477_9 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 505.0
HFD2_k127_7019632_0 MacB-like periplasmic core domain - - - 3.366e-283 893.0
HFD2_k127_7019632_1 acetyl-CoA hydrolase K18118 - 2.8.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 606.0
HFD2_k127_7019632_2 - - - - 0.000000000000000000000000005383 120.0
HFD2_k127_7037205_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.172e-213 681.0
HFD2_k127_7037205_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 393.0
HFD2_k127_7037205_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 325.0
HFD2_k127_7037205_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005737 289.0
HFD2_k127_7037205_4 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000001147 185.0
HFD2_k127_7037205_5 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000002615 188.0
HFD2_k127_7037205_6 orotate phosphoribosyltransferase activity K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000003151 188.0
HFD2_k127_7037205_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000006091 146.0
HFD2_k127_7037205_8 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000002712 92.0
HFD2_k127_7047456_0 AMP-binding enzyme K01897 - 6.2.1.3 3.212e-220 700.0
HFD2_k127_7047456_1 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 6.385e-220 689.0
HFD2_k127_7047456_10 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 381.0
HFD2_k127_7047456_11 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 329.0
HFD2_k127_7047456_12 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003242 286.0
HFD2_k127_7047456_13 Sensor histidine kinase PilS, PAS domain-containing K02668,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003298 285.0
HFD2_k127_7047456_14 lipoprotein localization to outer membrane K02004,K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001205 276.0
HFD2_k127_7047456_15 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001447 269.0
HFD2_k127_7047456_16 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000001597 261.0
HFD2_k127_7047456_17 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000004677 262.0
HFD2_k127_7047456_18 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000003433 261.0
HFD2_k127_7047456_19 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000009197 259.0
HFD2_k127_7047456_2 PFAM Type II secretion system protein E K02652 - - 3.258e-216 683.0
HFD2_k127_7047456_20 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000001365 243.0
HFD2_k127_7047456_21 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000001032 220.0
HFD2_k127_7047456_22 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000001276 214.0
HFD2_k127_7047456_23 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000000001659 194.0
HFD2_k127_7047456_24 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000003572 200.0
HFD2_k127_7047456_25 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000008413 196.0
HFD2_k127_7047456_26 FAD binding domain - - - 0.000000000000000000000000000000000000000000004724 184.0
HFD2_k127_7047456_27 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000007896 176.0
HFD2_k127_7047456_28 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000524 168.0
HFD2_k127_7047456_29 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02527,K02841,K02843,K12982 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000001292 147.0
HFD2_k127_7047456_3 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 5.809e-209 668.0
HFD2_k127_7047456_30 Protein tyrosine kinase - - - 0.000000000000000000000000000000002233 138.0
HFD2_k127_7047456_31 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000002516 123.0
HFD2_k127_7047456_32 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000001046 121.0
HFD2_k127_7047456_33 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000002396 113.0
HFD2_k127_7047456_34 Sigma-70 region 2 K03088 - - 0.0000000000000000000007383 104.0
HFD2_k127_7047456_35 Putative regulatory protein - - - 0.0000000000000000146 91.0
HFD2_k127_7047456_36 Pilus assembly protein K02662 - - 0.0000000006626 70.0
HFD2_k127_7047456_37 heat shock protein binding K05516 - - 0.000000002889 68.0
HFD2_k127_7047456_38 Methyltransferase domain - - - 0.00000003593 63.0
HFD2_k127_7047456_39 Serine aminopeptidase, S33 - - - 0.0000001625 64.0
HFD2_k127_7047456_4 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005087 540.0
HFD2_k127_7047456_40 PFAM Fimbrial assembly family protein K02663 - - 0.000007953 60.0
HFD2_k127_7047456_41 general secretion pathway protein D K02453 - - 0.0002819 51.0
HFD2_k127_7047456_5 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 515.0
HFD2_k127_7047456_6 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 505.0
HFD2_k127_7047456_7 Type II secretion system (T2SS), protein F K02455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 456.0
HFD2_k127_7047456_8 response regulator K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 447.0
HFD2_k127_7047456_9 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 424.0
HFD2_k127_7119386_0 Protein of unknown function (DUF3604) - - - 0.0 1017.0
HFD2_k127_7119386_1 Protein of unknown function (DUF3604) - - - 5.33e-245 774.0
HFD2_k127_7119386_10 Viral (Superfamily 1) RNA helicase K03581 - 3.1.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 508.0
HFD2_k127_7119386_11 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 449.0
HFD2_k127_7119386_12 SMART ATP-binding region, ATPase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 456.0
HFD2_k127_7119386_13 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 371.0
HFD2_k127_7119386_14 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 353.0
HFD2_k127_7119386_15 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 317.0
HFD2_k127_7119386_16 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001224 267.0
HFD2_k127_7119386_17 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001762 287.0
HFD2_k127_7119386_18 Domain of unknown function (DUF3943) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003231 272.0
HFD2_k127_7119386_19 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000006526 243.0
HFD2_k127_7119386_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 - 3.1.11.5 8.429e-234 769.0
HFD2_k127_7119386_20 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000001005 241.0
HFD2_k127_7119386_21 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000004049 212.0
HFD2_k127_7119386_22 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000000000000001376 143.0
HFD2_k127_7119386_23 cheY-homologous receiver domain - - - 0.000000000000000000000002399 106.0
HFD2_k127_7119386_24 Eukaryotic-type carbonic anhydrase K01674 - 4.2.1.1 0.00000000000000000001133 95.0
HFD2_k127_7119386_25 - - - - 0.0000000000806 70.0
HFD2_k127_7119386_3 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582,K16898 - 3.1.11.5,3.6.4.12 2.344e-226 764.0
HFD2_k127_7119386_4 Tetratricopeptide repeat - - - 5.991e-208 664.0
HFD2_k127_7119386_5 ADP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 578.0
HFD2_k127_7119386_6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 513.0
HFD2_k127_7119386_7 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008011 514.0
HFD2_k127_7119386_8 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 494.0
HFD2_k127_7119386_9 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 506.0
HFD2_k127_7166622_0 glutamate synthase, alpha subunit domain protein K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1212.0
HFD2_k127_7166622_1 AAA ATPase domain - - - 0.0 1073.0
HFD2_k127_7166622_10 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 340.0
HFD2_k127_7166622_11 PFAM peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 322.0
HFD2_k127_7166622_12 peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 293.0
HFD2_k127_7166622_13 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 293.0
HFD2_k127_7166622_14 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001727 248.0
HFD2_k127_7166622_15 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000002366 261.0
HFD2_k127_7166622_16 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000003288 205.0
HFD2_k127_7166622_17 PAS sensor protein - - - 0.000000000000000000000000000000000000000000000003774 179.0
HFD2_k127_7166622_18 peptidase U32 K08303 - - 0.000000000000000000000000000000000000000005639 167.0
HFD2_k127_7166622_19 DNA-binding transcription factor activity - - - 0.0000000000000000000000000000000000000002874 161.0
HFD2_k127_7166622_2 ATP-grasp domain K01905,K22224 - 6.2.1.13 2.151e-284 900.0
HFD2_k127_7166622_20 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000003149 162.0
HFD2_k127_7166622_21 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000079 160.0
HFD2_k127_7166622_22 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000001439 121.0
HFD2_k127_7166622_23 Alpha/beta hydrolase family - - - 0.0000000000000000000000000001484 124.0
HFD2_k127_7166622_24 PFAM EAL domain - - - 0.000000000000000000000001151 118.0
HFD2_k127_7166622_25 - - - - 0.00000000000000002697 84.0
HFD2_k127_7166622_26 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000006731 84.0
HFD2_k127_7166622_27 S4 RNA-binding domain K04762 - - 0.00000000000004848 82.0
HFD2_k127_7166622_28 Winged helix DNA-binding domain - - - 0.00000005482 61.0
HFD2_k127_7166622_3 Extracellular solute-binding protein K02027 - - 1.404e-226 707.0
HFD2_k127_7166622_4 Involved in the tonB-independent uptake of proteins - - - 5.86e-202 658.0
HFD2_k127_7166622_5 Belongs to the aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 542.0
HFD2_k127_7166622_6 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 480.0
HFD2_k127_7166622_7 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 461.0
HFD2_k127_7166622_8 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 440.0
HFD2_k127_7166622_9 Binding-protein-dependent transport system inner membrane component K02025,K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 434.0
HFD2_k127_7195425_0 Cytochrome c oxidase, subunit I K02274 - 1.9.3.1 1.749e-194 629.0
HFD2_k127_7195425_1 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 606.0
HFD2_k127_7195425_10 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000002497 180.0
HFD2_k127_7195425_11 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000001063 156.0
HFD2_k127_7195425_12 Cytochrome c oxidase, subunit II K02275 - 1.9.3.1 0.000000000000000000000000000000000000004177 153.0
HFD2_k127_7195425_13 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000000000000000000000002014 148.0
HFD2_k127_7195425_14 Cytochrome c - - - 0.000000000000000000000000000000001214 150.0
HFD2_k127_7195425_15 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000007399 132.0
HFD2_k127_7195425_16 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000001573 129.0
HFD2_k127_7195425_17 SnoaL-like domain - - - 0.00000000000000000000000000005132 127.0
HFD2_k127_7195425_18 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - 0.00000000000000000000000000729 121.0
HFD2_k127_7195425_19 methyltransferase activity - - - 0.000000000000000000000000239 111.0
HFD2_k127_7195425_2 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007715 544.0
HFD2_k127_7195425_20 Domain of Unknown Function (DUF1206) - - - 0.0000000000000000001088 98.0
HFD2_k127_7195425_21 Biopolymer transport protein K03560 - - 0.00000000000007946 79.0
HFD2_k127_7195425_22 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K21142 - 2.8.1.12 0.0000000000003462 72.0
HFD2_k127_7195425_23 - - - - 0.00001966 52.0
HFD2_k127_7195425_24 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.00008702 45.0
HFD2_k127_7195425_25 Putative zinc- or iron-chelating domain - - - 0.0003084 50.0
HFD2_k127_7195425_3 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 402.0
HFD2_k127_7195425_4 Acts as a magnesium transporter K04767,K06213,K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008013 396.0
HFD2_k127_7195425_5 PFAM Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 389.0
HFD2_k127_7195425_6 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 368.0
HFD2_k127_7195425_7 short-chain dehydrogenase K13774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005539 278.0
HFD2_k127_7195425_8 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000009581 250.0
HFD2_k127_7195425_9 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000164 200.0
HFD2_k127_7204485_0 Belongs to the CarB family K01955 - 6.3.5.5 3.32e-311 971.0
HFD2_k127_7204485_1 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 592.0
HFD2_k127_7204485_10 LAO AO transport system K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 320.0
HFD2_k127_7204485_11 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000009322 237.0
HFD2_k127_7204485_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000126 217.0
HFD2_k127_7204485_13 GHMP kinase K00869,K07031 - 2.7.1.168,2.7.1.36 0.000000000000000000000000000000000000000000000000000003539 203.0
HFD2_k127_7204485_14 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000006619 202.0
HFD2_k127_7204485_15 IstB-like ATP binding protein K02315 - - 0.000000000000000000000000000000000000000000000009874 180.0
HFD2_k127_7204485_16 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000002627 173.0
HFD2_k127_7204485_17 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.00000000000000000000000000000000000000009281 158.0
HFD2_k127_7204485_18 - - - - 0.0000000000000000000000000001133 121.0
HFD2_k127_7204485_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000001484 119.0
HFD2_k127_7204485_2 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 593.0
HFD2_k127_7204485_20 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000002057 112.0
HFD2_k127_7204485_21 - - - - 0.0000000000005978 78.0
HFD2_k127_7204485_22 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000001237 66.0
HFD2_k127_7204485_23 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000001694 56.0
HFD2_k127_7204485_24 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0003898 47.0
HFD2_k127_7204485_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 569.0
HFD2_k127_7204485_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 469.0
HFD2_k127_7204485_5 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 441.0
HFD2_k127_7204485_6 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 362.0
HFD2_k127_7204485_7 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 381.0
HFD2_k127_7204485_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 353.0
HFD2_k127_7204485_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005406 355.0
HFD2_k127_7247597_0 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000004911 227.0
HFD2_k127_7247597_1 cell septum assembly - - - 0.000000000000000000000000000000000000003092 162.0
HFD2_k127_7247597_2 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000997 147.0
HFD2_k127_7247597_3 Permease - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000000256 138.0
HFD2_k127_7247597_4 - - - - 0.00000000000108 71.0
HFD2_k127_7247597_5 - - - - 0.000000007581 59.0
HFD2_k127_7247597_6 Periplasmic or secreted lipoprotein - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - 0.00000752 52.0
HFD2_k127_7247597_7 Belongs to the UPF0761 family K07058 - - 0.00001468 55.0
HFD2_k127_7317389_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 6.81e-258 822.0
HFD2_k127_7317389_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.727e-252 808.0
HFD2_k127_7317389_2 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 540.0
HFD2_k127_7317389_3 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003317 238.0
HFD2_k127_7317389_4 thiolester hydrolase activity K06889 - - 0.0000000000000000676 88.0
HFD2_k127_7317389_5 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000004929 52.0
HFD2_k127_7317389_6 Belongs to the 'phage' integrase family - - - 0.0005003 45.0
HFD2_k127_7317389_7 Adenylate cyclase - - - 0.000539 43.0
HFD2_k127_7482929_0 Involved in the tonB-independent uptake of proteins - - - 5.144e-225 725.0
HFD2_k127_7482929_1 Involved in the tonB-independent uptake of proteins - - - 1.978e-215 709.0
HFD2_k127_7482929_10 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 399.0
HFD2_k127_7482929_11 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 377.0
HFD2_k127_7482929_12 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 310.0
HFD2_k127_7482929_13 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001707 289.0
HFD2_k127_7482929_14 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004504 278.0
HFD2_k127_7482929_15 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000002756 204.0
HFD2_k127_7482929_16 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000005285 174.0
HFD2_k127_7482929_17 - - - - 0.0000000000000000000000000000000000000006902 166.0
HFD2_k127_7482929_18 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000005969 91.0
HFD2_k127_7482929_19 Regulatory protein, FmdB family - - - 0.00000000000000927 76.0
HFD2_k127_7482929_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 2.774e-214 698.0
HFD2_k127_7482929_20 Sporulation and spore germination - - - 0.000000000007236 75.0
HFD2_k127_7482929_3 Protein kinase domain K12132 - 2.7.11.1 6.879e-214 694.0
HFD2_k127_7482929_4 WD40 domain protein beta Propeller K12132 - 2.7.11.1 5.248e-203 679.0
HFD2_k127_7482929_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 601.0
HFD2_k127_7482929_6 glutamate-cysteine ligase activity K06048 GO:0003674,GO:0003824,GO:0016874,GO:0016879 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008434 510.0
HFD2_k127_7482929_7 OPT oligopeptide transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 500.0
HFD2_k127_7482929_8 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 409.0
HFD2_k127_7482929_9 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 424.0
HFD2_k127_7590587_0 ACT domain K12524 - 1.1.1.3,2.7.2.4 4.445e-260 831.0
HFD2_k127_7590587_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 6.785e-218 689.0
HFD2_k127_7590587_10 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 347.0
HFD2_k127_7590587_11 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 349.0
HFD2_k127_7590587_12 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 313.0
HFD2_k127_7590587_13 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 320.0
HFD2_k127_7590587_14 ABC transporter, (ATP-binding protein) K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 296.0
HFD2_k127_7590587_15 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 287.0
HFD2_k127_7590587_16 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002424 289.0
HFD2_k127_7590587_17 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000002139 287.0
HFD2_k127_7590587_18 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001448 259.0
HFD2_k127_7590587_19 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002378 267.0
HFD2_k127_7590587_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 559.0
HFD2_k127_7590587_20 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001443 245.0
HFD2_k127_7590587_21 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000231 201.0
HFD2_k127_7590587_22 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.00000000000000000000000000000000000000000000000000006254 204.0
HFD2_k127_7590587_23 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000009529 170.0
HFD2_k127_7590587_24 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.000000000000000000000000000000000000003885 149.0
HFD2_k127_7590587_25 COG3209 Rhs family protein - - - 0.00000000000000000000000000000000000001212 169.0
HFD2_k127_7590587_26 membrane - - - 0.0000000000000000000000000000000000001659 156.0
HFD2_k127_7590587_27 RES - - - 0.000000000000000000000000000000000000194 160.0
HFD2_k127_7590587_28 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000000000172 119.0
HFD2_k127_7590587_29 positive regulation of growth K19687 - - 0.000000000000000000004145 95.0
HFD2_k127_7590587_3 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 528.0
HFD2_k127_7590587_30 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000001017 108.0
HFD2_k127_7590587_31 Protein of unknown function (DUF2384) - - - 0.0000000000000000004303 92.0
HFD2_k127_7590587_32 Ig-like domain from next to BRCA1 gene - - - 0.0000000000000000007049 100.0
HFD2_k127_7590587_33 Periplasmic or secreted lipoprotein K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.000000000000000000705 95.0
HFD2_k127_7590587_34 Glycosyl transferase family group 2 - - - 0.000000000000000143 93.0
HFD2_k127_7590587_35 PFAM regulatory protein, MerR - - - 0.0000000000000006731 84.0
HFD2_k127_7590587_36 nitric oxide dioxygenase activity - - - 0.00000000000005347 77.0
HFD2_k127_7590587_37 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000005847 81.0
HFD2_k127_7590587_38 Periplasmic or secreted lipoprotein K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00000000002318 78.0
HFD2_k127_7590587_39 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00000000004906 69.0
HFD2_k127_7590587_4 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 476.0
HFD2_k127_7590587_40 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678 - 0.0000000008283 70.0
HFD2_k127_7590587_41 amine dehydrogenase activity - - - 0.00000002337 61.0
HFD2_k127_7590587_42 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000001964 64.0
HFD2_k127_7590587_5 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 430.0
HFD2_k127_7590587_7 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 420.0
HFD2_k127_7590587_8 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 360.0
HFD2_k127_7590587_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 355.0
HFD2_k127_7624676_0 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1174.0
HFD2_k127_7624676_1 xanthine dehydrogenase activity K04108 - 1.3.7.9 7.05e-298 934.0
HFD2_k127_7624676_10 COG0076 Glutamate decarboxylase and related PLP-dependent K01593,K13745 - 4.1.1.105,4.1.1.28,4.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 396.0
HFD2_k127_7624676_11 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 356.0
HFD2_k127_7624676_12 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 328.0
HFD2_k127_7624676_13 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 324.0
HFD2_k127_7624676_14 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 317.0
HFD2_k127_7624676_15 peptidoglycan biosynthetic process K03980,K21004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 311.0
HFD2_k127_7624676_16 NAD dependent epimerase dehydratase family K01784,K02473 - 5.1.3.2,5.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 310.0
HFD2_k127_7624676_17 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000138 285.0
HFD2_k127_7624676_18 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009994 285.0
HFD2_k127_7624676_19 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002828 291.0
HFD2_k127_7624676_2 Protein kinase domain K12132 - 2.7.11.1 6.02e-210 682.0
HFD2_k127_7624676_20 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004503 288.0
HFD2_k127_7624676_21 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001157 258.0
HFD2_k127_7624676_22 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006567 244.0
HFD2_k127_7624676_23 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000004921 239.0
HFD2_k127_7624676_24 Amino-transferase class IV K00824,K00826 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21,2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000222 241.0
HFD2_k127_7624676_25 PFAM response regulator receiver K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000003552 233.0
HFD2_k127_7624676_26 Glycosyl transferase 4-like - - - 0.000000000000000000000000000000000000000000000000000000000000004608 237.0
HFD2_k127_7624676_27 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000001698 222.0
HFD2_k127_7624676_28 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000013 221.0
HFD2_k127_7624676_29 protein histidine kinase activity K02484,K07640,K07643,K07645,K07649,K19609 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001971 199.0
HFD2_k127_7624676_3 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 551.0
HFD2_k127_7624676_30 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000001574 203.0
HFD2_k127_7624676_31 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000005756 186.0
HFD2_k127_7624676_32 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000005802 202.0
HFD2_k127_7624676_33 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000009437 196.0
HFD2_k127_7624676_34 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000002058 177.0
HFD2_k127_7624676_35 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000002667 182.0
HFD2_k127_7624676_36 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000004204 163.0
HFD2_k127_7624676_37 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000001856 151.0
HFD2_k127_7624676_38 RNA recognition motif - - - 0.0000000000000000000000000001601 119.0
HFD2_k127_7624676_39 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000005445 119.0
HFD2_k127_7624676_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 527.0
HFD2_k127_7624676_40 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000001818 103.0
HFD2_k127_7624676_41 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000616 104.0
HFD2_k127_7624676_42 Cupin domain - - - 0.000000000000000000065 99.0
HFD2_k127_7624676_43 DinB superfamily - - - 0.000000000000000005285 92.0
HFD2_k127_7624676_44 protein conserved in bacteria - - - 0.000000000000000007542 89.0
HFD2_k127_7624676_45 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000007401 67.0
HFD2_k127_7624676_46 chlorophyll binding - - - 0.0000002197 64.0
HFD2_k127_7624676_48 Virulence factor membrane-bound polymerase, C-terminal K13009 - - 0.0003775 53.0
HFD2_k127_7624676_5 Aldo/keto reductase family K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 481.0
HFD2_k127_7624676_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000842 446.0
HFD2_k127_7624676_7 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 425.0
HFD2_k127_7624676_8 Protein of unknown function (DUF2891) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009271 403.0
HFD2_k127_7624676_9 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 400.0
HFD2_k127_7629152_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 417.0
HFD2_k127_7629152_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 400.0
HFD2_k127_7629152_2 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 346.0
HFD2_k127_7629152_3 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 349.0
HFD2_k127_7629152_4 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000003549 133.0
HFD2_k127_7629152_5 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000006417 56.0
HFD2_k127_7629152_6 Adenylate cyclase - - - 0.00003383 49.0
HFD2_k127_7640891_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 568.0
HFD2_k127_7640891_1 von Willebrand factor (vWF) type A domain K07114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 373.0
HFD2_k127_7640891_2 of the beta-lactamase K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000001382 193.0
HFD2_k127_7640891_3 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000002176 166.0
HFD2_k127_7640891_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000006504 158.0
HFD2_k127_7640891_5 Secretin and TonB N terminus short domain K02666 - - 0.000000000000000000002817 98.0
HFD2_k127_7640891_6 Redoxin - - - 0.0000000000000000004339 92.0
HFD2_k127_7640891_7 Protein of unknown function (DUF4230) - - - 0.00000000001005 73.0
HFD2_k127_787708_0 Protein kinase domain K12132 - 2.7.11.1 1.219e-242 782.0
HFD2_k127_787708_1 Protein kinase domain K12132 - 2.7.11.1 5.651e-197 645.0
HFD2_k127_787708_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 595.0
HFD2_k127_787708_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 499.0
HFD2_k127_787708_4 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 464.0
HFD2_k127_787708_5 - - - - 0.0000000000000000005408 100.0
HFD2_k127_787708_6 nucleic acid-binding protein, contains PIN domain - - - 0.000001358 56.0
HFD2_k127_7917190_0 Malate synthase K01638 - 2.3.3.9 0.0 1197.0
HFD2_k127_7917190_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 1.565e-234 734.0
HFD2_k127_7917190_2 Domain of Unknown Function (DUF748) - - - 1.524e-210 698.0
HFD2_k127_7917190_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 505.0
HFD2_k127_7917190_4 Bacterial regulatory protein, Fis family K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 453.0
HFD2_k127_7917190_5 PFAM FAD linked oxidase domain protein K00104,K11472 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 380.0
HFD2_k127_7917190_6 L-Lactate permease K03303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004949 352.0
HFD2_k127_7917190_7 FAD dependent oxidoreductase K15736 - - 0.00000000000000002031 83.0
HFD2_k127_7917190_8 Malate synthase K01638 - 2.3.3.9 0.00008669 54.0
HFD2_k127_7933442_0 Involved in the tonB-independent uptake of proteins - - - 4.936e-224 722.0
HFD2_k127_7933442_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 548.0
HFD2_k127_7933442_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 389.0
HFD2_k127_7966824_0 Cytochrome c - - - 2.167e-207 653.0
HFD2_k127_7966824_1 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007348 368.0
HFD2_k127_7966824_2 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003346 286.0
HFD2_k127_7966824_3 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000007923 219.0
HFD2_k127_7966824_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000005375 202.0
HFD2_k127_7966824_5 PFAM DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000004392 164.0
HFD2_k127_7966824_6 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000004514 64.0
HFD2_k127_7966824_7 YXWGXW repeat (2 copies) - - - 0.00000562 55.0
HFD2_k127_7970620_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1201.0
HFD2_k127_7970620_1 FAD linked oxidases, C-terminal domain K06911 - - 0.0 1197.0
HFD2_k127_7970620_10 Protein kinase domain - - - 0.0000000000000000000000000000000000000000000005356 171.0
HFD2_k127_7970620_11 DoxX K15977 - - 0.00000000000000000000000000000000000003445 149.0
HFD2_k127_7970620_12 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000752 140.0
HFD2_k127_7970620_13 protein involved in formation of curli polymers - - - 0.00000000000000000000000000000005652 138.0
HFD2_k127_7970620_14 - - - - 0.000000000000000000000000000003352 128.0
HFD2_k127_7970620_15 - - - - 0.000000000000000000000000000109 120.0
HFD2_k127_7970620_16 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000004014 119.0
HFD2_k127_7970620_17 gluconolactonase activity - - - 0.0000000000008405 80.0
HFD2_k127_7970620_18 Protein kinase domain - - - 0.000000000002652 73.0
HFD2_k127_7970620_2 PFAM 4Fe-4S K00184,K21308 - - 7.804e-231 735.0
HFD2_k127_7970620_20 Domain of unknown function (DUF4440) - - - 0.0000005238 58.0
HFD2_k127_7970620_21 MacB-like periplasmic core domain - - - 0.0001477 46.0
HFD2_k127_7970620_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 437.0
HFD2_k127_7970620_4 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 368.0
HFD2_k127_7970620_5 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 323.0
HFD2_k127_7970620_6 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000009503 235.0
HFD2_k127_7970620_7 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000003555 216.0
HFD2_k127_7970620_8 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000006721 218.0
HFD2_k127_7970620_9 - - - - 0.0000000000000000000000000000000000000000000004054 173.0
HFD2_k127_8013111_0 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 353.0
HFD2_k127_8013111_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000007151 221.0
HFD2_k127_8013111_2 negative regulation of transcription, DNA-templated K10947 - - 0.000000000000000000000000000000000007491 140.0
HFD2_k127_8013111_3 - - - - 0.0000000000001222 72.0
HFD2_k127_8013111_4 membrane - - - 0.000008405 57.0
HFD2_k127_8013111_5 Addiction module toxin, RelE StbE family - - - 0.00003487 47.0
HFD2_k127_8013111_6 - - - - 0.0000682 52.0
HFD2_k127_8014052_0 peptidase K01415,K07386 - 3.4.24.71 6.276e-301 937.0
HFD2_k127_8014052_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 502.0
HFD2_k127_8014052_2 Beta-lactamase class C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 399.0
HFD2_k127_8014052_3 Beta-lactamase class C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 396.0
HFD2_k127_8014052_4 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001604 288.0
HFD2_k127_8014052_5 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000001559 247.0
HFD2_k127_8014052_6 NTPase - - - 0.000000000000000000000000000000000000006071 151.0
HFD2_k127_8014052_7 Alkylmercury lyase - - - 0.000000000000001185 83.0
HFD2_k127_8014052_8 Alkylmercury lyase - - - 0.0000000000006027 71.0
HFD2_k127_8121753_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 1.508e-276 874.0
HFD2_k127_8121753_1 Involved in the tonB-independent uptake of proteins - - - 6.955e-194 632.0
HFD2_k127_8121753_2 regulation of translation K03530 - - 0.000000000000000000000000000000000007988 139.0
HFD2_k127_8121753_3 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.000000000000000000000000000000158 131.0
HFD2_k127_8121753_4 Thioesterase superfamily - - - 0.00000000000000000000002182 108.0
HFD2_k127_8121753_5 nucleotidyltransferase activity - - - 0.00000000000001168 76.0
HFD2_k127_8160722_0 Lamin Tail Domain K07004 - - 4.988e-241 782.0
HFD2_k127_8160722_1 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 588.0
HFD2_k127_8160722_10 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000069 208.0
HFD2_k127_8160722_11 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000001471 190.0
HFD2_k127_8160722_12 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000001456 185.0
HFD2_k127_8160722_13 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000000000000567 123.0
HFD2_k127_8160722_14 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.0000000000000000000003416 106.0
HFD2_k127_8160722_15 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K06378 - - 0.0000000000005289 74.0
HFD2_k127_8160722_16 helix_turn_helix, Lux Regulon - - - 0.0000000009856 69.0
HFD2_k127_8160722_2 protein secretion by the type I secretion system K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 568.0
HFD2_k127_8160722_3 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005996 555.0
HFD2_k127_8160722_4 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 439.0
HFD2_k127_8160722_5 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 447.0
HFD2_k127_8160722_6 Serine phosphatase RsbU, regulator of sigma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 356.0
HFD2_k127_8160722_7 PFAM alanine racemase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 316.0
HFD2_k127_8160722_8 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000378 245.0
HFD2_k127_8160722_9 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000009486 216.0
HFD2_k127_8212009_0 Amidohydrolase family - - - 0.0 1447.0
HFD2_k127_8212009_1 Sortilin, neurotensin receptor 3, - - - 0.0 1265.0
HFD2_k127_8212009_10 glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 557.0
HFD2_k127_8212009_11 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 558.0
HFD2_k127_8212009_12 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 537.0
HFD2_k127_8212009_13 Metallo-beta-lactamase superfamily K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 475.0
HFD2_k127_8212009_14 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 436.0
HFD2_k127_8212009_15 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 445.0
HFD2_k127_8212009_16 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 422.0
HFD2_k127_8212009_17 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 433.0
HFD2_k127_8212009_18 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 402.0
HFD2_k127_8212009_19 YVTN family beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 375.0
HFD2_k127_8212009_2 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 0.0 1167.0
HFD2_k127_8212009_20 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 377.0
HFD2_k127_8212009_21 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 319.0
HFD2_k127_8212009_22 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 302.0
HFD2_k127_8212009_23 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 295.0
HFD2_k127_8212009_24 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002801 277.0
HFD2_k127_8212009_25 Belongs to the FPG family K05522,K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0003906,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034599,GO:0034641,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0090304,GO:0097159,GO:0097506,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000005276 249.0
HFD2_k127_8212009_26 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000003424 246.0
HFD2_k127_8212009_27 metalloendopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001119 237.0
HFD2_k127_8212009_28 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000000000966 201.0
HFD2_k127_8212009_29 - - - - 0.0000000000000000000000000000000000000000000000000000001414 210.0
HFD2_k127_8212009_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 6.127e-256 801.0
HFD2_k127_8212009_30 PFAM Multiple antibiotic resistance (MarC)-related K05595 - - 0.000000000000000000000000000000000000000000000000000001795 200.0
HFD2_k127_8212009_31 methyltransferase - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000003188 190.0
HFD2_k127_8212009_32 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000003021 186.0
HFD2_k127_8212009_33 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000002445 194.0
HFD2_k127_8212009_34 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000002301 160.0
HFD2_k127_8212009_35 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000004262 164.0
HFD2_k127_8212009_36 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000002618 158.0
HFD2_k127_8212009_37 - - - - 0.000000000000000000000000000000000000002682 155.0
HFD2_k127_8212009_38 - - - - 0.000000000000000000000000000000000000005109 160.0
HFD2_k127_8212009_39 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000009544 155.0
HFD2_k127_8212009_4 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 4.524e-218 685.0
HFD2_k127_8212009_40 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000007698 141.0
HFD2_k127_8212009_41 Nitrous oxide-stimulated promoter - - - 0.00000000000000000000000000000000008948 137.0
HFD2_k127_8212009_42 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000008121 129.0
HFD2_k127_8212009_43 PFAM glycine cleavage H-protein - - - 0.0000000000000000000000000000001033 136.0
HFD2_k127_8212009_44 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000001933 117.0
HFD2_k127_8212009_46 phosphorelay signal transduction system K02437 - - 0.000000000000000000000000004002 123.0
HFD2_k127_8212009_47 - - - - 0.000000000000000000000000005103 122.0
HFD2_k127_8212009_48 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000008121 113.0
HFD2_k127_8212009_49 alkyl hydroperoxide reductase K03386,K03564 - 1.11.1.15 0.000000000000000003852 86.0
HFD2_k127_8212009_5 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 2.174e-215 678.0
HFD2_k127_8212009_50 YceI-like domain - - - 0.00000000000000001079 94.0
HFD2_k127_8212009_51 YXWGXW repeat (2 copies) - - - 0.000000000001285 79.0
HFD2_k127_8212009_52 Domain of unknown function (DUF4142) K08995 - - 0.00000000001181 73.0
HFD2_k127_8212009_53 LytTr DNA-binding domain K02477 - - 0.0000000002739 66.0
HFD2_k127_8212009_55 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10794 - 1.21.4.1 0.00001125 51.0
HFD2_k127_8212009_56 12 heme-binding sites - - - 0.00006843 55.0
HFD2_k127_8212009_6 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 4.695e-213 694.0
HFD2_k127_8212009_7 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 5.08e-203 642.0
HFD2_k127_8212009_8 aspartate--ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 613.0
HFD2_k127_8212009_9 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008787 594.0
HFD2_k127_8300073_0 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 373.0
HFD2_k127_8300073_1 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000001395 159.0
HFD2_k127_8300073_2 COG0840 Methyl-accepting chemotaxis protein - - - 0.00000000000000000000000004148 114.0
HFD2_k127_8300073_4 - - - - 0.00000000000008717 80.0
HFD2_k127_8300073_5 Adenylate cyclase - - - 0.000539 43.0
HFD2_k127_8535189_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.018e-275 865.0
HFD2_k127_8535189_1 Involved in the tonB-independent uptake of proteins - - - 1.464e-198 648.0
HFD2_k127_8535189_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000004163 80.0
HFD2_k127_8535189_2 Involved in the tonB-independent uptake of proteins - - - 9.329e-196 644.0
HFD2_k127_8535189_3 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 327.0
HFD2_k127_8535189_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 314.0
HFD2_k127_8535189_5 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000002674 255.0
HFD2_k127_8535189_6 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000001432 185.0
HFD2_k127_8535189_7 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000002897 179.0
HFD2_k127_8535189_8 collagen metabolic process - - - 0.000000000000000000000000000001943 131.0
HFD2_k127_8535189_9 Adenylate cyclase - - - 0.0000000000000000542 89.0
HFD2_k127_8751007_0 Spermine/spermidine synthase domain - - - 9.094e-194 626.0
HFD2_k127_8751007_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 331.0
HFD2_k127_8751007_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009014 316.0
HFD2_k127_8751007_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 306.0
HFD2_k127_8751007_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000003256 228.0
HFD2_k127_8751007_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000002829 193.0
HFD2_k127_8751007_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000002434 183.0
HFD2_k127_8751007_7 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000001015 165.0
HFD2_k127_889133_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008156 491.0
HFD2_k127_889133_1 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 302.0
HFD2_k127_889133_10 diguanylate cyclase - - - 0.00000001337 64.0
HFD2_k127_889133_2 Bacterial regulatory proteins, tetR family K16137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000364 248.0
HFD2_k127_889133_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001274 240.0
HFD2_k127_889133_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000001267 224.0
HFD2_k127_889133_5 PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - 0.0000000000000000000005835 110.0
HFD2_k127_889133_6 Transcriptional regulator - - - 0.0000000000000000001785 97.0
HFD2_k127_889133_8 Adenylate cyclase - - - 0.0000000000000000469 89.0
HFD2_k127_889133_9 Cys Met metabolism K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.000000000002419 68.0
HFD2_k127_967411_0 response regulator - - - 0.00000000000000000000000000000000000000001588 168.0
HFD2_k127_967411_1 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000000000000000000000000000004418 151.0